Dermala-Ebook

Live your best skin.

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January 2019

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THE GUIDE

Introduction.........................................................................3
Acne and bacteria................................................................4
Acne and the microbiome...................................................4
Why don’t regular treatments work...................................5
How is Dermala different?..................................................6
What’s in the #FOBO Kit?................................................... 7
SCANTILY PadTM AM/PM Acne Treatment............................8
SUPPLEMEANT to BeTM Daily Pre + Probiotic Mix.............. 9
C L E A N S E w i t h B e n e fi t s T M A M / P M C l e a n s e r . . . . . . . . . . . . . . . . . . . . . . . . . 10
P A T C H M e ( I f Y o u C a n ) T M T a r g e t e d P i m p l e s P a t c h e s . . . . . . . . . 11
D e r m a l a A c n e T r a c k e r T M A p p . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12

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DERMALA #FOBO (Fear of Breaking Out) PERSONALIZED ACNE SOLUTION

What is the #FOBO kit? It’s what happens when teens with acne grow up
to be PhDs, MDs, big-data scientists, and software engineers. When they
join up, take a new look at old problems, and realize they could be addressing
the causes of acne, not the symptoms.
After a few years and some hard work, they end up with
six patents pending on a treatment that fights acne from
the outside and inside. It uses a modern suite of probiotics,
prebiotics, and postbiotics to balance the microbiome and
purge the bacteria that cause breakouts. And it uses big
data, machine learning, and artificial intelligence to personalize
and continually optimize the treatment.
You messed with the wrong people, acne.

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ACNE’S A BACTERIA?

Yep. Cutibacterium acnes. About 700 million people, most between 12 and 28, are affected. During puberty, our hormones
kick off a cascade of changes, one of which is sebum production. Sebum is a kind of oil the skin produces, and when it
mixes with dead skin cells it’s a perfect pore clogger.
Those clogged pores are like a dinner buffet for C. acnes. They multiply, inflame the skin, and produce acne lesions (better
known to you as pimples).
Yet another reason to hate puberty.

WHY THE MICROBIOME STUFF, THEN?

Good question. Our microbiome is just the collection of bacteria in
and on our bodies. Most of it’s good for us, helping to protect against
germs, break down food for energy, produce vitamins, and develop
our immune system. Sometimes our microbiome gets imbalanced,
though. That’s called dysbiosis. It can happen both on the skin and
in the gut.
Whether the ecosystem is a forest or your body, when one species
grows too fast, it hurts the others. In the case of acne, dysbiosis in the
skin causes C. acnes to get stronger and eventually outgrow the good
guys. The imbalance in the gut increases inflammation throughout the
body, which just makes the inflammation happening on the skin worse.
Hellooo acne.

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WHY DON’T THE REGULAR TREATMENTS WORK?

Did you know the last new treatment for acne was developed
more than 60 years ago? NASA didn’t exist. Doctors thought
smoking was healthy. The average house cost $13,000. Is this
the era of medicine we should be trusting our skin to?

Go down the list - benzoyl peroxide, retinoids, antibiotics - they’re
all short-term fixes with big-time side effects. They each address
just one of the many causes of acne, so if they work at all it’s only
for a short time. Then you’re stuck with the aftermath.

• Benzoyl peroxide and retinoids dry out the skin like crazy.
Which, yes, clears up that one pimple, but guess what the
body does with dry, irritated skin? It makes the only lubricant
it can: sebum. And the cycle repeats.

• 60% of people with acne have some level of antibiotic resistance.
If you’re one of them, good luck trying antibiotics for persistent
acne. And, antibiotics kill good bacteria too, further messing with
your microbiome balance.

Accutane (isotretinoin) is another bad option. It has been associated
with birth defects, depression, gastrointestinal disorders, nose bleeds,
joint pain, and poor bone development. Yikes. It’s the last resort for a
reason.

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HOW IS DERMALA DIFFERENT?

Well, our solutions are newer than 60 years old. It’s amazing
what you can accomplish with a modern understanding of the
human microbiome, the gut-skin axis, DNA sequencing, and
some data science.

Our acne-fighting regimen was developed by scientists
at leading U.S. universities and perfected by experts in
acne treatment. It fights all the causes of acne, not just
one of them. It has been clinically tested, and approved
by the FDA.*

*FDA Monograph 21 CFR part 333 subpart D

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WHAT’S IN THE #FOBO KIT?

It’s a skincare personal assistant who knows you inside and out, and has everything you need:

1 SCANTILY PadTM AM/PM Acne Treatment 2 SUPPLEMEANT to BeTM Daily Pre + Probiotic Mix

3 CLEANSE with BenefitsTM AM/PM Cleanser 4 PATCH Me (If You Can)TM Targeted Pimple Patches

Each one is formulated with clean, natural ingredients, and a specific blend of pre-, pro-, and postbiotics. Which aren’t just
buzzwords, by the way. Probiotics are the good bacteria themselves, prebiotics are their food, and postbiotics are the
metabolites (a.k.a. body-beneficial compounds) they produce. Working together, they balance the microbiome by helping
your good bacteria flourish, and keeping the bad bacteria in check.

Also, the #FOBO Kit is personalized to you. Throughout your skincare journey, you’ll track your progress with the Dermala
Acne Tracker app (it’s free, app store, iOS/Android - you know the drill). As you share your results, it learns what works for
your skin, and tweaks each month’s kit to keep up with you.

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1 SCANTILY PadTM AM/PM Acne Treatment

FDA-approved.* Personalized. Topical. Leave-on. Kind of a boring set
of adjectives, but we’re more about exciting you with the results.
Each pad is infused with a unique combination of our patented SE
Microbiome Complex™, salicylic acid, and Aloe vera. The SE
Microbiome Complex™ is a unique blend of Staphylococcus
epidermidis pre- and postbiotics. That’s what kills the acne-causing
bacteria and nourishes acne-fighting bacteria on your skin. The
salicylic acid dissolves dead skin cells, which opens clogged pores
and prevents new clogs from forming. Aloe vera soothes the skin
and reduces inflammation. And the ratio between these ingredients
is adjusted, month-to-month, based on your results.

Fewer, smaller, and less-severe pimples. No lame side-effects like
inflammation, redness, peeling, or itching. Like we said, we’re about
the results.

INGREDIENTS†:
Organic aloe vera, organic grain alcohol, cocamidopropyl dimethylamine, SE Microbiome Complex™†, salicylic acid, sodium
hydroxide, organic lemon essential oil. †Patents pending. The SCANTILY Pad Acne Treatment is personalized. The specific
formulation depends on individual acne condition, treatment progress, and skin needs.

DIRECTIONS:
SCANTILY Pad™ topical treatment is BFFs with CLEANSE with Benefits™. Use them together, each morning and evening.

*FDA Monograph 21 CFR part 333 subpart D

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2 SUPPLEMEANT to BeTM Daily Pre + Probiotic Mix

You can’t just swallow a bunch of good bacteria and get a magically
healthier microbiome. If a supplement doesn’t correctly balance a lot
of different elements, you’re just *ahem* flushing it down the drain.
Ours is an exclusive blend of:

Prebiotics - a combination of bacteriophages formulated to
attack bad bacteria by destabilizing their cell walls (science!)
6.25 billion CFU of probiotics - species that have been specifically
associated with reduction of inflammatory acne and improved
skin health
Zinc - a natural antibiotic that has reduced acne severity in clinical
trials
Vitamins – best vitamins to restore skin health after acne breakouts
Spinach extract - a super blend of antioxidants, vitamins, enzymes,
and minerals that nurture the good bacteria

All those nutrients set up the probiotics to do their thing: optimize gut health, support your immune system, reduce the oiliness
of your skin, bring down inflammation throughout your body, and most importantly, help kill off C. acnes.

INGREDIENTS*:
60 mg vitamin C (100% DV), 10 IU vitamin E (33% DV), 15 mg zinc (as gluconate) (100% DV), 6.25 billion CFU probiotic mix
(Bacillus subtilis, Bifidobacterium longum, Bifidobacterium lactis Bi-07, Lactobacillus plantarum, Bifidobacterium lactis,
Lactobacillus rhamnosus), 100 mg Solarplast® (spinach extract), 15 mg prebiotics PreforPro® (LH01 – Myoviridae, LL5 –
Siphoviridae, T4D – Myoviridae, LL12 – Myoviridae), rice maltodextrin, delayed release vegetable capsule, medium-chain
triglycerides. *Patents pending.

DIRECTIONS:
A capsule per day keeps bad bacteria away!

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3 CLEANSE with BenefitsTM AM/PM Cleanser

Cleansers are a paradox: they have to clean away dirt and oil, but
can’t over-dry the skin. Getting ours right took a pending U.S. patent
on our SE Microbiome Complex™ that targets acne-causing bacteria
and helps the acne-fighting strains to flourish. It also took natural
plant oils, amino acids, vitamins, and a slightly acidic pH balance,
because that’s what helps fight acne. (Typical cleansers have alkaline
pH, which is actually associated with acne.)

Break it all down and you’ve got a powerful cleanser, healthier skin,
and less acne. Paradox solved.

INGREDIENTS*:

Water, lauryl glucoside, laureth-7 citrate, glyceryl cocoate, propanediol,
PEG-7 glyceryl cocoate, Citrus sinensis (sweet orange) oil, Citrus
limonium (lemon) oil, citric acid, SE Microbiome Complex™*, glycerin,
phosphatidylcholine, panthenol (provitamin B5), arginine, proline,
glycine, alanine, phenoxyethanol, potassium sorbate, ethylhexylglycerin,
tetrasodium EDTA. *Patents pending.

DIRECTIONS:
Just like the name says: AM/PM. Use it morning and evening before
applying SCANTILY Pad™ topical acne treatment.

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4 PATCH Me (If You Can)TM Targeted Pimple Patches

There are escape-artist pimples that no amount of
skin nourishment or microbiome balancing can lock
down. Fortunately, you’ve got back-up, in the form
of our clear, drug-free, disposable patches. They
vacuum up oil and pus, reduce inflammation, speed
up healing, and prevent the bacteria from spreading.

INGREDIENTS:
Hydrocolloid.

DIRECTIONS:
Peel a patch off the sheet and cover your pimple.
Overnight works great, but less time works too.
Throw it away in the morning and get on with life!

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Dermala Acne TrackerTM App

Much to the annoyance of many skincare scientists, everyone is
different. Our genes, our microbiomes, our diets, our levels of stress,
the environments where we live - they’re all unique. Understanding
that interplay is really hard, and that’s why old acne treatments
focused on the symptoms but could never help with the causes. To
actually help with acne you have to stick with a person as they use
the product, getting to know them, and what works for their skin.
You have to collect and crunch a lot of data. In the words of all
previous skincare scientists, “Nah.”

Well, we’ve got your back. We love big data!

HERE’S HOW IT WORKS:

1 First, take the quiz (on our site, or in the app) - This gives us the info we need about your acne, skin health, and yourwww.dermala.com
https://itunes.apple.com/us/app/dermala-acne-tracker/id1434940440?mt=8&_ke=&ls=1

particular challenges so we can personalize your first treatments.

2 Get the first #FOBO Kit - Your unique kit arrives and goes to work attacking your acne.

3 Start tracking – Use the app to take your ‘before’ selfie. After that, check in once a week, take a selfie, and record how
you’re doing.

Optimization ahead - Our algorithm customizes your next round of treatment based on your actual results and your

4 optimized #FOBO Kit arrives every month. The app also lets you view your progress week by week, gives you a skin

health score, delivers insight into how your lifestyle is affecting your skin, and offers tips for what can help.

5 Enjoy lasting clear skin! - (Unless you’d rather just buy random “all-purpose” products and hope something works, in
which case, you know ... you do you.)

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Live your best skin.

Dermala Inc.
3210 Merryfield Row
San Diego, CA 92121

www.dermala.com
This guide is the sole and exclusive property of Dermala Inc.
These creative guidelines are proprietary to Dermala and may not be used or reproduced in
whole or in part without Dermala’s express prior written authorization from Dermala.