MPN Facts

Myeloproliferative Neoplasms (MPN)

MPN is a group of rare Many patients have other
disorders of the bone marrow health problems which can
that cause an increase in the make diagnosis and treatment
number of blood cells. more difficult.

These conditions are rare and The aim of treatment is usually
usually develop slowly to control symptoms rather
over years. than cure the condition.

Most patients diagnosed are
over 60 years old.

Source: Cancer Research UK

What causes MPN?

The exact cause of MPN's remains unknown but there
are thought to be a number of factors involved.

A mutation of a particular gene known as JAK2
Janus Kinase 2 (JAK2), is found in a large
proportion of people with MPN's.

The discovery of a mutation in the JAK2 gene is important because
it is likely to have a significant impact on the way MPN's are
diagnosed and treated.

Long-term exposure to radiation or high levels of certain chemicals
is also believed to present an increased risk of developing MPN.

Source: Leukaemia Foundation

MPN - Symptoms

Many patients have NO symptoms when they are first diagnosed
with an MPN and the disease is picked up accidentally during a
routine blood test or physical examination.
In other cases, people go to see their GP because they have some
troubling symptoms of their disease.
When symptoms do occur, they develop gradually over time.
Common symptoms include:

Blurred vision Dizziness Severe itching
Headaches Night sweats High blood pressure

Fatigue Weakness

Source: Leukaemia Foundation

MPN - Treatment

MPN usually CANNOT be cured but there are treatments that
make the condition manageable and control symptoms.

Treatment of MPN's depends on
the type and on the presence of
symptoms.

Treatment AIMS to correct the
abnormal blood counts.

Some people do NOT experience ANY symptoms, requiring NO
treatment.

Source: UCSH Health

MPN - Treatments

Low dose chemotherapy pills - Hydrea, can be given to patients
with essential Thrombocythemia and Polycythemia Vera to lower
platelet and red blood cell counts. Phlebotomy (the removal of
blood intravenously) is an effective strategy for lowering red
blood cell counts and controlling symptoms.

Chemotherapy Radiation Stem Cell
Therapy Transplantation
Surgery
(spleen removal) Biological Therapy

Source: UCSH Health