(GNUR 294) 4 Adams, Michael Patrick_ Urban, Carol Quam - Pharmacology_ connections to nursing practice (2018_2019, Pearson) - libgen.li-1201-1565

1518 Index PhosLo. See calcium acetate Plavix. See clopidogrel
phosphate, deficiencies in, 569t plecanatide, 1105t
PharmFacts (continued) phosphodiesterase III inhibitors, 632t, 634 Plenaxis. See abarelix
urinary tract infections, 903t Plendil. See felodipine
varicella zoster virus, 775t inamrinone, 664t Pletal. See cilostazol
vitamin toxicity, 1133t milrinone, 632t, 635 PMC (pseudomembranous colitis), 872
vulvovaginal candidiasis, 946t phosphodiesterase 5 inhibitors, 1316–1319 PML (progressive multifocal
sildenafil, 205, 1317–1318, 1317t
Phenazine. See perphenazine tadalafil, 1317, 1317t, 1319, 1319, 1321t leukoencephalopathy), 324, 1115
phencyclidine (PCP), 103t, 449, 461 vardenafil, 1317, 1317t, 1319 PMS (premenstrual syndrome), 1269
phendimetrazine, 1167t Phospholine Iodide. See echothiophate iodide pneumococcal conjugate vaccine (PCV), 768
phenelzine, 187, 270–271 phospholipids, 489, 490f, 976 pneumococcal infection, 768–769
Phenergan. See promethazine phosphorus (phosphate), 1141t, 1142 pneumococcal polysaccharide vaccine (PPV),
Phenergan with Codeine. See promethazine photophobia, 173
phenobarbital photosensitivity, 872, 872t 768–769
phototherapy, 258, 258t, 1382 pneumonia, 837t, 842t, 935t, 983t, 1015t
adverse effects, 60t, 246, 664t phototoxicity, 61, 892 pneumonic plague, 1413
clinical applications, 246, 339 Phthirus pubis, 1368 pneumothorax, 1155t
distribution of, 126 physical dependence, 450 PNS. See peripheral nervous system
drug interactions, 64, 247, 339, 457t physostigmine, 158t, 173, 364, 1416t POCD (postoperative cognitive
enzyme induction and, 37 phytonadione. See vitamin K
mechanism of action, 246 PICC (peripherally inserted central catheter) dysfunction), 436t
nursing responsibilities, 247 Podophyllum peltatum, 1057
overdose treatment, 247 lines, 1029 poisonings
routes and dosages, 246t picornaviruses, 977t
for seizures, 335t, 340t PIH (prolactin-inhibiting hormone), 1185 management of, 1416–1420, 1416t
phenothiazines, 288–291 pill rolling, 306 medication overdoses, 1416, 1416t
adverse effects, 1315t pilocarpine, 158t, 159, 160, 1394t, 1396 Nursing Practice Applications, 1420–1421t
antipsychotic, 288–291, 289t Pilopine. See pilocarpine suspected, 116t
breast-feeding and, 106t pimecrolimus, 1377–1378 Poladex. See dexchlorpheniramine
chlorpromazine, 60t, 282, 289t, 290–291, pimozide, 289t, 293 Polaramine. See dexchlorpheniramine
PIMs (potentially inappropriate polarized cells, 643
457t, 664t poliomyelitis, 767t, 773
drug interactions, 91t, 210, 269 medications), 128 Polocaine. See mepivacaine
fluphenazine, 289, 289t, 291 pindolol, 206, 207t, 210 polyclonal antibodies, 755. See also
for nausea and vomiting, 1120, 1121t pinna, 1402
perphenazine, 289t, 291, 1121t Pin-Rid. See pyrantel pamoate antithymocyte globulin
prochlorperazine, 31, 289t, 291, 414, Pinworm Caplets. See pyrantel polycyclic aromatic hydrocarbons (PAHs), 64t
Pin-X. See pyrantel polycystic ovary syndrome, 1279
1030, 1121t pioglitazone, 1215t, 1216, 1219–1220, 1222 polydipsia, 1194, 1204
thioridazine, 289, 289t, 291 Piper methysticum. See kava polyethylene glycol, 743, 1105t
trifluoperazine, 289t, 291 piperacillin, 664t, 850t, 855 polyherbacy, 92t
phenoxybenzamine, 202, 203t, 206 pirbuterol, 195, 196 polymeric formulas, for enteral nutrition, 1149
phentermine, 1166, 1167t, 1170 piroxicam, 731–732t polymyxin B, 863, 894t, 894, 1368
phentolamine PIs (protease inhibitors), 1007–1010 polypeptides, 870
adverse effects, 202 pitavastatin, 496, 497t, 499 polyphagia, 1203
for extravasation, 188, 191, 192, 367 Pitocin. See oxytocin polypharmacy, 77, 124
for hypertension, 206, 381, 596t pituitary gland, 1184t, 1185, 1187t polysaccharide iron complex, 706, 706t
with papaverine, 1317 placebos, 19, 58 polysomnography, 233
routes and dosages, 203t placenta, 100 Polysporin, 863, 894
phenylacetic acids, 733 Placidyl. See ethchlorvynol polystyrene sulfonate, 572
phenylbutazone, 60t, 63 Plan B, 1291t, 1300, 1301 polythiazide and prazosin, 587t
phenylephrine Plaquenil. See hydroxychloroquine polyuria, 1194, 1204
adverse effects, 193–194 plaques polyvinyl alcohol, 1400t
chemical structure of, 188 pomalidomide, 1067t
clinical applications and considerations, 192, in atherosclerosis, 604 Pomalyst. See pomalidomide
in multiple sclerosis, 320–321, 322 Ponstel. See mefenamic acid
193–194, 822 in psoriasis, 1378–1379, 1381 Pontocaine. See tetracaine
in combination products, 815t, 825t Plasbumin. See normal serum albumin poppy plant, 398
mechanism of action, 193 plasma cells, 720 Portrazza. See necitumumab
nursing responsibilities, 194 plasma cholinesterase. See posaconazole, 938t, 941, 943
routes and dosages, 189t, 822t, 1400t positive symptoms, of schizophrenia, 283, 283t
phenylpropanolamine, 825t, 1166 pseudocholinesterase postantibiotic effect, 877, 889
Phenytek. See phenytoin plasma half-life (t1/2), 41 posterior pituitary gland, 1185
phenytoin Plasma-Lyte, 566, 567 postexposure prophylaxis, for HIV, 1013–1014
adverse effects, 59–60t, 664t plasminogen, 680 postganglionic neurons, 147
breast-feeding and, 106t Plasmodium, 954, 955, 955f. See also malaria postherpetic neuralgia, 774
clinical applications and considerations, plateau drug plasma levels, 42, 42f postictal state, 335
platelet enhancers, 698, 700–702 postmarketing surveillance, 20
344–345 postmenopausal bleeding, 1269
drug interactions, 63, 457t, 670t, 1152 eltrombopag, 694t, 700, 702 postoperative cognitive dysfunction
for dysrhythmias, 648t, 651 oprelvekin. See oprelvekin
in geriatric patients, 129t romiplostim, 694t, 700, 702 (POCD), 436t
mechanism of action, 337 platelets, 476, 565, 663 postoperative medications, 441
for neuropathic pain, 410 Platinol. See cisplatin postpartum depression, 255
pregnancy category, 102t platinum compounds post-traumatic epilepsy (PTE), 345t
protein binding in, 113, 126, 333 carboplatin, 542t, 664t, 1038t, 1041 post-traumatic stress disorder (PTSD), 230, 245
for seizures, 335t, 340t cisplatin, 59–60t, 542t, 1032, 1038t, 1041 Posture. See calcium phosphate tribasic
pheochromocytoma, 186t, 204 oxaliplatin, 1038t, 1041 potassium acetate, 573
phobias, 230
phosgene oxime, 1415t

Index  1519

potassium bicarbonate, 573 alcohol use during, 101–102, 456 Prevacid/Prevacid SoluTab. See lansoprazole
potassium channel blockers, 648t, 653–654 caffeine intake during, 387t Prezista. See darunavir
cocaine use during, 462–463 PRH (prolactin-releasing hormone), 1185
adverse effects, 653–654 corticosteroid use for women at risk of Prialt. See ziconotide
drugs in class Priftin. See rifapentine
preterm labor, 1254t prilocaine, 437t, 440
amiodarone. See amiodarone eclampsia during, 333 Prilosec. See omeprazole
dofetilide, 648t, 654 gestational diabetes and, 1203 Primacor. See milrinone
ibutilide, 648t, 654–655 herbal supplement use during, 90–91 primaquine, 955, 956t, 957
sotalol, 207t, 210, 648t, 655 iron requirements during, 692t primary hypertension, 583. See also
mechanism of action, 649f, 653 nausea and vomiting during, 1119, 1119t
potassium chloride (KCl), 572–573, 1141t nicotine during, 101–102, 102t, 463–464 hypertension
potassium citrate, 573 nicotine use during, 101–102 Primaxin. See imipenem-cilastatin
potassium gluconate, 573 perinatal transmission of HIV/AIDS, primidone, 339, 340t
potassium imbalances, 569t, 570f, 571–573 Primsol. See trimethoprim
potassium iodide (KI), 1239 1014–1015 Principen. See ampicillin
potassium iodide and iodine, 1238t, 1239 pharmacotherapy during Prinivil. See lisinopril
potassium-sparing diuretics, 544, 544f, Prinzide, 529
antibiotics, 845–846 Prinzmetal’s (vasospastic) angina, 605
550–552 antidepressants, 101t Pristiq. See desvenlafaxine
adverse effects, 551 drug transfer across placenta, 100 Privine. See naphazoline
doses and routes, 550t fetal stage of development and, 103–104 ProAmatine. See midodrine
drugs in class physiologic changes altering Probalan. See probenecid
Pro-Banthine. See propantheline
amiloride, 545, 550, 550t, 552 pharmacokinetic responses, 99–100, 100f probenecid, 1355, 1356t, 1357, 1359
eplerenone. See eplerenone pregnancy risk categories, 60, 101–102, procainamide, 648t, 649–650, 664t
spironolactone. See spironolactone procaine, 41, 437t, 438
triamterene, 545, 550, 550t, 552, 587t, 589 102–103t procarbazine, 1038t, 1042
mechanism of action, 544f, 551 rationale for, 99 Procardia/Procardia XL. See nifedipine
therapeutic effects and uses, 551 preeclampsia during, 333 Prochieve. See progesterone
potency, 48–50, 49f preterm labor, 1277–1278 prochlorperazine, 31, 289t, 291, 414, 1030, 1121t
potentially inappropriate medications (PIMs), 128 seizures in, 332 procoagulants, 662
Potiga. See ezogabine substance abuse during, 101–102, 103t Procrit. See epoetin alfa
poxvirus, 977t thyroid gland in, 1231t prodrugs, 36
PPDs (purified protein derivatives), 918 tuberculosis and, 921 prodysrhythmics, 642, 642t
PPIs. See proton pump inhibitors urinary tract infections during, 903 Pro-Fast. See phentermine
PPN (peripheral vein parenteral vaccines during, 765 progesterone, 59t, 99–100, 1266t, 1270, 1289.
vitamins during, 101, 1134t
nutrition), 1152 pregnancy categories, 60, 101–102, 102–103t See also progestins
PPV (pneumococcal polysaccharide Pregnyl. See chorionic gonadotropin-HCG progestins. See also medroxyprogesterone
preimplantation phase, of fetal development,
vaccine), 768 Nursing Practice Applications, 1270–1271t
PQ intervals, 644t 103–104 in oral contraceptives, 1288–1289
PQ segments, 644t preload, 482, 482f therapeutic effects and uses, 1267
Pradaxa. See dabigatran Premarin. See conjugated estrogens types of, 1268t
pralatrexate, 1043, 1044t, 1047 premenstrual syndrome (PMS), 1269 Proglycem. See diazoxide
pralidoxime, 161, 1416t Premphase. See conjugated estrogens with Prograf. See tacrolimus
pramipexole, 309t, 311–312 progressive multifocal leukoencephalopathy
pramlintide, 1209 medroxyprogesterone
PrandiMet, 1215t Prempro. See conjugated estrogens with (PML), 324, 1115
Prandin. See repaglinide proguanil-atovaquone, 955, 956t, 957
prasugrel, 675t, 675, 677 medroxyprogesterone proinflammatory substances, 718
Praluent. See alirocumab prenatal multivitamins, 102t prolactin-inhibiting hormone (PIH), 1185
Pravachol. See pravastatin Preparing for Advanced Practice prolactin-releasing hormone (PRH), 1185
pravastatin, 64, 496, 497t, 499 Proleukin. See aldesleukin
Pravigard PAC, 499 anxiety disorders in pediatric patients, Prolia. See denosumab
praziquantel, 967, 968t, 969 treatment for, 247t Promacta. See eltrombopag
prazosin, 105t, 202, 203t, 205, 587t, 591 promethazine
preclinical research, 19 asthma, 937t
Precose. See acarbose chronic kidney disease, 546t breast-feeding and, 106t
prediabetes, 1204 contraceptive choices, 1296t clinical applications, 289, 291, 401, 441
prednicarbate, 1378t GERD, treatment of, 1090t in combination products, 825t
prednisolone, 906, 1252t HPV vaccination, 775t routes and dosages, 814t, 1121t, 1122
prednisone intravenous acetaminophen, 735t Prometrium. See progesterone
medication errors, 75t propafenone, 648t, 651–652, 670t
for adrenal insufficiency, 1253 medication routines, and geriatric propantheline, 172t, 175
breast-feeding and, 106t proparacaine, 1400t, 1400
in cancer treatment, 1054 patients, 129t Propecia. See finasteride
for gout, 1355 myasthenia gravis, treatment for, 164t Propine. See dipivefrin
for infantile spasms, 336 obesity in primary care, 1169t Propionibacterium acnes, 1370
for multiple sclerosis, 324 otitis media, 1404t propionic acids, 733
in pain management, 411 polyherbacy, risk in geriatric patients, 92t propofol, 425t, 428–429, 457t
routes and dosages, 1052t, 1252t suspected poisoning, 116t propoxyphene, 403
for transplant rejection, 757 traumatic brain injury, 1189t propranolol
preeclampsia, 333 vitamins during pregnancy, 1134t adverse effects, 208–209
preexposure prophylaxis, for HIV, 1014 Zika virus, 106t breast-feeding and, 106t
Prefest. See estradiol and norgestimate preoperative medications, 441 clinical applications and considerations,
pregabalin, 335t, 337, 341t, 351–352 Prepidil. See dinoprostone
preganglionic neurons, 152 preschoolers, 115. See also pediatric patients 208–209, 241
pregnancy. See also lactation Prescription Drug User Fee Act of 1992

(PDUFA), 16, 21
prescription drugs. See drug(s)
prescriptive authority, 22–23
preterm labor, 1277

1520 Index

propranolol (continued) Nursing Practice Application, 1098–1099t Pure Food and Drug Act of 1906 (PFDA), 15–17
drug interactions, 457t nursing responisbilities, 1091 purified protein derivatives (PPDs), 918
for dysrhythmias, 648t, 653 therapeutic effects and use, 1090–1091 purine analogs, 1043–1044
genetic polymorphisms and actions of, 136 Protonix. See pantoprazole
hydrochlorothiazide and, 587t Protopam. See pralidoxime cladribine, 1044t, 1046
for hypertension, 591 Protopic. See tacrolimus clofarabine, 1044t, 1046
mechanism of action, 209 prototype drugs, 7 fludarabine, 1044t, 1046
for migraine prophylaxis, 416, 417t protozoan infections, 953–954 mercaptopurine, 1044t, 1047, 1114
protein binding in, 113 classification and pathogenesis of, 953–954, 953t nelarabine, 1044t, 1047
routes and dosages, 207t, 609t malarial, 954–958. See also malaria pentostatin, 1044t, 1047
sensitivity in Asian patients, 652t nonmalarial, 958–965. See also nonmalarial thioguanine, 1044t, 1047
Purinethol. See mercaptopurine
proprietary drugs. See trade name drugs protozoan infections Purkinje fibers, 481
propylthiouracil, 59t, 102t, 1181, Nursing Practice Applications, 970–971t pustular psoriasis, 1379t
protozoans, defined, 953 PUVA therapy, 1382–1383
1238–1239, 1238t protriptyline, 267, 260t, 269, 417t PVD (peripheral vascular disease), 679
Proquin XR. See ciprofloxacin Provenge. See sipuleucel-T pyelonephritis, 901, 903
Proscar. See finasteride Proventil. See albuterol Pylera, 1097
ProSom. See estazolam Proventil Repetabs. See albuterol pyramidal tracts, 225
prostaglandin(s) Provera. See medroxyprogesterone pyrantel pamoate, 967, 968t, 969
Provigil. See modafinil pyrazinamide, 918, 920t, 921, 924
as abortifacient, 1302, 1302t proviruses, 978 pyrethrin, 1369, 1370
for glaucoma, 1393–1395 Prozac. See fluoxetine pyridostigmine, 158t, 162, 163–164
pruritus, 61, 1367 pyridoxine (vitamin B6), 361, 921, 1132–1133t,
bimatoprost, 1395, 1394t pseudocholinesterase, 150, 178
latanoprost, 980, 1394–1395, 1394t pseudoephedrine 1138–1139, 1416t
travoprost, 1395, 1394t acrivastine with, 814t, 817 pyrilamine, 825t
for inflammation, 718t adverse effects, 823 pyrimethamine, 905t, 906, 960t, 962,
physiological properties of, 725–726 breast-feeding and, 106t
as uterine stimulant, 1274 clinical applications, 194, 823 964–965, 1043
carboprost, 1273t, 1274, 1275, in combination products, 815t, 823t pyrimidine analogs, 1043–1044
drug interactions, 823
1301–1302t, 1302 illegal uses of, 193, 194, 462, 822t capecitabine, 1044t, 1045–1046
dinoprostone, 1273t, 1274, 1275, mechanism of action, 823 cytarabine, 889, 1044t, 1046
nursing responsibilities, 824 floxuridine, 1044t, 1046
1301–1302t, 1302 restrictions on sale, 194, 823 fluorouracil, 102t, 889, 936, 1026, 1044t,
misoprostol. See misoprostol routes and dosages, 822t
prostaglandin E2, 1083 pseudogout, 1357t 1046–1047
prostate cancer, 1023t. See also benign -prostatic pseudomembranous colitis (PMC), 872 gemcitabine, 1044t, 1047
Pseudomonas aeruginosa, 837t, 842t, 855, 859, PZA. See pyrazinamide
hyperplasia
prostatitis, 901 871, 889 Q
Prostigmin. See neostigmine psilocybin, 459f, 460
Prostin E2. See dinoprostone psoralens, 1382 QRS complex, 644, 644f, 644t
protease, 998 psoriasis, 1378–1383, 1379–1381t, 1379f Qsymia, 1167t, 1169
protease inhibitors (PIs), 1007–1010 psoriasis vulgaris, 1379t QT intervals, 61, 644t
psoriatic arthritis, 1379t Qtern, 1215t
atazanavir, 1002t, 1008–1009 psoriatic erythroderma, 1379t Quaalude. See methaqualone
darunavir, 1002t, 1008, 1009 PSVT (paroxysmal supraventricular Qualaquin. See quinine
fosamprenavir, 1002t, 1009 quazepam, 236t, 238t, 240
indinavir, 91t, 664t, 1002t, 1009 tachycardia), 645 Qudexy XR. See topiramate
lopinavir with ritonavir, 62, 1002t, 1008 psychodynamic therapy, 258t Quelicin. See succinylcholine
nelfinavir, 1002t, 1009 psychological dependence, 450 Questran. See cholestyramine
ritonavir, 62, 64, 1002t, 1008, 1009 psychomotor seizures. See complex partial quetiapine fumarate, 275t, 277, 294t, 296–297
saquinavir, 91t, 1002t, 1009 QuickCaps. See diphenhydramine
tipranavir, 1002t, 1009–1010 seizures Quillivant XR. See methylphenidate
protease-activated receptor-1 antagonists, psychosis, 282, 284, 293t. See also schizophrenia quinapril, 528t, 530, 590, 629t
psychosocial influences, on quinidine, 647, 650–651, 664t, 670t
616 quinidine gluconate, 648t, 955
protein synthesis, 838, 869–870, 869f pharmacotherapy, 134 quinidine sulfate, 648t
protein synthesis inhibitors psychostimulants. See central nervous quinine, 955, 956t, 957–958
quinolones. See fluoroquinolones
aminoglycosides. See aminoglycosides system stimulants quinupristin-dalfopristin, 65, 842, 880t, 881, 881
macrolides. See macrolides psyllium (herbal), 90 Quixin. See levofloxacin
mechanism of action, 870, 871f psyllium mucilloid, 1105t, 1107 Qutenza. See capsaicin
miscellaneous agents, 880–882, 880t PT (prothrombin time), 664 Qvar. See beclomethasone
tetracyclines. See tetracyclines PTE (post-traumatic epilepsy), 345t
proteins, in enteral nutrition, 1149–1150 PTH (parathyroid hormone), 1179, 1330 R
Proteus mirabilis, 836, 837t PTSD (post-traumatic stress disorder), 230, 245
prothrombin, 478 PTU. See propylthiouracil RA. See rheumatoid arthritis
prothrombin time (PT), 664 pubic lice, 1368–1369 RAAS. See renin-angiotensin-aldosterone
proton pump inhibitors (PPIs), 1088–1092, PUD. See peptic ulcer disease
Pulmicort. See budesonide system
1089t, 1092t pulmonary edema, 623, 626 rabeprazole, 1089t, 1092
adverse effects, 1088, 1091 pulmonary embolism, 662–663 rabies, 767t, 772
doses and routes, 1089t pulmonary excretion, 39 rabies immune globulin, 776, 777t
drugs in class pulmonary perfusion, 787 race, influence on pharmacotherapy, 134–136.
Pulmozyme. See dornase alfa
dexlansoprazole, 1091–1092 pupil, of eye, 1391 See also Treating the Diverse Patient;
esomeprazole, 1089t, 1091 specific racial groups
lansoprazole, 1088, 1089t, 1091–1092 racemic amphetamine, 378
omeprazole. See omeprazole radiation sickness, 1415
pantoprazole, 1089t, 1091
rabeprazole, 1089t, 1092
mechanism of action, 1088, 1090, 1089f, 1091

Index  1521

radiation therapy, 1024 renin-angiotensin-aldosterone system (RAAS), Reye’s syndrome, 118, 727, 735, 1098
radioactive iodide, 1238t, 1239–1240 523–538 Rezulin. See troglitazone
radiologic contrast media, 60t, 542t rhabdomyolysis, 62, 359, 496
raloxifene, 102t, 1052t, 1054, 1341t, 1343–1344 blood pressure and, 485, 525 rheumatoid arthritis (RA)
raltegravir, 1002t, 1010 components of, 524–526, 524–526f
ramelteon, 236t, 241, 243 drugs affecting, 527–534 genetic influences in, 1348t
ramipril, 528t, 530, 590, 629t inflammation in, 718–719
ramucirumab, 1064t, 1065 ACE inhibitors, 527–531, 528t nonpharmacologic therapies, 1349
Ranexa. See ranolazine aldosterone antagonists, 527, 531t, 534 Nursing Practice Applications, 1353–1354t
ranitidine, 441, 664t, 1093–1094, 1093t ARBs, 531–534, 531t pathophysiology, 1348–1350, 1349f
ranolazine, 606, 609t renin inhibitors, 527, 531t pharmacotherapy, 1254, 1348–1351, 1350t
Rapaflow. See silodosin physiological actions of, 526–527 Rheumatrex. See methotrexate
Rapamune. See sirolimus points for drug intervention, 527 Rhinocort/Rhinocort Aqua. See budesonide
rapid eye movement (REM) sleep, 232, 232t Renova. See tretinoin rhinophyma, 1373
Raptiva. See efalizumab ReoPro. See abciximab Rho[D] immune globulin, 776–778, 777t
RAS (reticular activating system), 220, 224, reoviruses, 977t RhoGAM. See Rho[D] immune globulin
repaglinide, 1214t, 1218 rhubarb, 1106, 1107
224f, 231, 231f Repatha. See evolocumab ribavirin, 102t, 745, 987t, 990, 991, 992, 1414
rasagiline, 309t, 313 repetitive transcranial magnetic stimulation ribociclib, 1064t
rasburicase, 1357 riboflavin (vitamin B2), 417t, 1132–1133t, 1138
rashes, drug-induced, 61 (rTMS) therapy, 258t ribosomes, 839, 849f, 870
Raynaud’s disease, 204, 204t replacement therapies Rickettsia rickettsii. See Rocky Mountain spotted
Razadyne. See galantamine
RCA (root-cause analysis), 79–80, 80f corticosteroids, 1250–1253 fever
RDAs (recommended dietary allowances), 1133 hormones, 1180, 1271–1273 RID. See pyrethrin
reabsorption, 541 nicotine, , 165, 451, 463–464, 464f rifabutin, 920t, 921, 924–925, 931, 1097, 1269
Rebetol. See ribavirin thyroid hormones, 1232–1235, 1233t, 1234t Rifadin. See rifampin
Rebif. See interferon(s), IFN beta-1a replication cycle, of viral infections, 976–978, 978f Rifamate, 925
rebound cardiac excitation, 208 repolarization, 643 rifampin
rebound congestion, 194, 822 reproductive system regulation
rebound depression, 267 female, 1263, 1264–1265f adverse effects, 664t, 894
rebound effects, in substance abuse, 450 male, 1308–1310, 1309f clinical applications, 894, 919, 929
rebound insomnia, 234, 238 reproductive system toxicity, 1031 in combination products, 925
reboxetine, 264 Repronex. See menotropins drug interactions, 457t, 670t
receptors Requip. See ropinirole routes and dosages, 894t, 920t
Rescriptor. See delavirdine rifamycin derivatives, 925
genetic polymorphisms and, 136 reserpine, 592 rifapentine, 920t, 925
in geriatric patients, 127 resistance, to antibiotics, 839–844, 839t, 841f Rifater, 925
pharmacodynamic theory of, 50–51 respiratory depression, with opioids, 400–401, rifaximin, 1114t
types of, 50f rilpivirine, 1002t, 1007
Reclast. See zoledronate 412 Rilutek. See riluzole
recombinant technology vaccines, 764t, 765 respiratory system riluzole, 325
Recombivax HB. See hepatitis B vaccine rimabotulinumtoxinB, 325, 366t,, 368t
recommended dietary allowances (RDAs), 1133 drug excretion by, 39 Rimactane. See rifampin
Recothrom. See thrombin, topical lower, 787–788, 787f rimantadine, 983, 983t, 985
rectal route of administration, 32 upper, 811–812, 811f rimonabant, 1166
red blood cells. See erythrocytes rest-and-digest response, 145, 156, 157, 158, 202 Ringer’s solution, 567, 570
refeeding syndrome, 1151 Restasis. See cyclosporine ophthalmic emulsion ringworm. See tinea capitis
reference product, 9 Restoril. See temazepam Riomet. See metformin
reflex tachycardia, 159, 204, 485, 593, 608 Retavase. See reteplase Riopan, 1095t
Refludan. See lepirudin rete ridges, 1365 risedronate, 1340t1341t, 1343
refractory period, 643 reteplase, 680t, 682 risk management, 79
regional anesthesia, 423 reticular activating system (RAS), 220, 224–225, risk-benefit ratio, 59
Regitine. See phentolamine Risperdal/Risperdal Consta/Risperdal M-TAB.
Reglan. See metoclopramide 224f, 231, 231f, 381
Regonol. See pyridostigmine reticular formation, 461 See risperidone
regorafenib, 1064t Retin-A. See tretinoin risperidone
regulations. See laws and regulations retinoids, 1373
Relafen. See nabumetone adverse effects, 275t, 294–295
Relaxin. See methocarbamol adapalene, 1372t, 1373, 1374 for bipolar disorder, 275t, 277
Relenza. See zanamivir isotretinoin. See isotretinoin clinical applications and considerations,
Relistor. See methylnaltrexone tazarotene, 1372t, 1375, 1380t, 1381
Relpax. See eletriptan tretinoin, 1372t, 1373–1374 293–294, 317
REM (rapid eye movement) sleep, 232, 232t retinopathy, diabetic, 1206 long-acting preparation, 287
Remeron. See mirtazapine retrograde infections, 901 mechanism of action, 294
Remicade. See infliximab Retrovir. See zidovudine for organic brain syndrome, 289–290
remifentanil, 404, 424, 425t, 426–427 retroviruses, 977t, 997. See also HIV/AIDS routes and dosages, 275t, 294t
Reminyl. See galantamine reuptake, 151 Ritalin/Ritalin SR. See methylphenidate
renal corpuscle, 540 reverse cholesterol transport, 491 ritodrine, 1277
renal excretion, 38–39 reverse remodeling, 630 ritonavir, 62, 64, 819, 1002t, 1003, 1008.
renal failure, 39, 541–543, 543t reverse transcriptase, 997
renal physiology, 540–541, 540f, 542f reverse transcriptase inhibitors, 1003–1006 See also lopinavir with ritonavir
renin, 525 reversible cholinesterase inhibitors. Rituxan. See rituximab
renin inhibitors, 527, 531t, 587t. See also rituximab, 1064t, 1065, 1350t, 1352–1353
See nonnucleoside reverse rivaroxaban, 665t, 670, 671, 674
aliskiren transcriptase inhibitors; rivastigmine, 158t, 317, 317t, 320
nucleoside/nucleotide reverse rizatriptan, 414t, 416
transcriptase inhibitors Robaxin. See methocarbamol
ReVia. See naltrexone Robinul. See glycopyrrolate
Revlimid. See lenalidomide Robitussin A-C, 825t
Revonto. See dantrolene sodium
Reyataz. See atazanavir

1522 Index drugs in class adverse effects, 293, 294t
aspirin. See aspirin for Alzheimer’s disease, 317
Robitussin DM. See dextromethorphan choline magnesium trisalicylate, 727t, 730 for bipolar disorder, 277
Rocaltrol. See calcitriol; vitamin D magnesium salicylate, 575, 727t, 730, 1142 dopamine system stabilizers, 296
Rocephin. See ceftriaxone salsalate, 727t, 730–731 drugs in class
Rocky Mountain spotted fever, 837t, 871
rocuronium, 176t, 180 mechanism of action, 725–726, 726f, 728 aripiprazole, 275t, 277, 294t, 296–300
rofecoxib, 733 therapeutic effects and uses, 727–728 asenapine, 275t, 277, 294t, 295
roflumilast, 798t, 801 salicylic acid, 725, 728, 925, 1380t, 1381 clozapine, 294t, 295
Rogaine. See minoxidil salicylism, 729 iloperidone, 294t, 295
Rohypnol. See flunitrazepam saline/osmotic cathartics, 1106 lurasidone, 294t, 295–296
Rolaids, 1095t Salk, Jonas, 774 olanzapine. See olanzapine
Romazicon. See flumazenil salmeterol, 196, 793t, 794 paliperidone, 290, 294t, 296
romidepsin, 1067, 1068t Salmonella, 837t quetiapine fumarate, 275t, 277, 294t, 296
romiplostim, 694t, 700, 702 salsalate, 727t, 730–731 risperidone. See risperidone
root-cause analysis (RCA), 79–80, 80f Salsitab. See salsalate ziprasidone, 275t, 277, 294t, 296
ropinirole, 309t, 312–313 Samsca. See tolvaptan mechanism of action, 293
ropivacaine, 437t, 440–441 Sancuso. See granisetron route and dosages for, 294t
rosacea, 1373 Sandimmune. See cyclosporine for schizophrenia, 293–298
roseola, 979 Sandostatin. See octreotide weight gain in children using, 297t
rosiglitazone, 1215t, 1219 Sansert. See methysergide secretion, 524–525
rosuvastatin, 496, 497t, 498 Saphris. See asenapine Sectral. See acebutolol
Rotarix, 776 saquinavir, 91t, 1002t, 1009 secukinumab, 1380t
RotaTeq, 776 Sarafem. See fluoxetine sedatives, 236, 452, 457t. See also barbiturates;
rotavirus, 776 sarcolemma, 511
rotigotine, 309t, 313 sarcomas, 1041, 1044 benzodiazepines; nonbenzodiazepine
routes of administration sarcoplasmic reticula, 511 anxiolytics
sargramostim, 694t, 698, 1030 seizures, 330–354
absorption, impact on, 29–33 sarilumab, 1350t Alzheimer’s disease and, 331t
buccal, 31 sarin, 1415t classification of, 334–336
enteral, 29–31 satiety, 1164 convulsions vs., 33–332
inhalation, 788–790 satiety center, 1164, 1165 defined, 331
intra-arterial, 1029 Savaysa. See edoxaban etiology of, 331, 331t
intradermal, 32–33 Savella. See milnacipran generalized, 334–335, 334t
intramuscular, 33, 113 saw palmetto, 87t, 87, 88t, 1322t in geriatric patients, 333, 335t
intranasal, 32 saxagliptin, 1214t, 1215t, 1221 impact on quality of life, 332
intraperitoneal, 1029 Saxenda. See liraglutide nonpharmacologic therapies, 333, 333t, 335
intrathecal, 1029 SCA (sudden cardiac arrest), 656t partial, 335t, 335
intravenous, 26, 33, 1029 scabies, 1368 in pediatric patients, 333, 334, 335–336
intravesicular, 1029 Schedule I drugs, 234, 449 pharmacotherapy. See antiepileptic drugs
ophthalmic, 32 Schedule II drugs, 22, 234, 382 in pregnancy and lactation, 331–332
oral, 28, 28f, 31, 113, 1028–1029 Schedule III drugs, 234 selective estrogen receptor modulators
otic, 32 Schedule IV drugs, 234, 242 (SERMs), 1051, 1054, 1343–1344
parenteral, 32 scheduled drugs, 22, 22t, 449 fulvestrant, 1052t, 1054
for pediatric patients, 31 schizoaffective disorder, 284 raloxifene, 1052t, 1053, 1054, 1343–1344
rectal, 32 schizophrenia tamoxifen. See tamoxifen
subcutaneous, 32–33, 113 etiology of, 284 toremifene, 1052t, 1054
sublingual, 31 genetic influences on, 284 selective serotonin reuptake inhibitors
topical, 31, 32, 33, 113 nonpharmacologic therapies for, 284–285 (SSRIs)
vaginal, 32 in pediatric patients, 284t as adjuvant analgesics, 410, 411t
Roxanol. See morphine sulfate pharmacotherapy. See antipsychotics adverse effects, 244, 259260, 1315t
Rozerem. See ramelteon prevalence of, 283t for bipolar disorder, 277
rTMS (repetitive transcranial magnetic prognosis, 286 for cataplexy, 233
symptoms of, 283–285, 283t clinical applications for, 244–245, 244t
stimulation) therapy, 258t school-age children, 115. See also pediatric patients for depression, 260t, 261–263, 263f
rubella (German measles), 767t, sclera, 1390, 1391 drug interactions, 66t, 101t, 295, 314
scleroderma, 204t, 747 drugs in class
773, 1368 sclerosing, 1029 citalopram, 244t, 260t, 263, 411
rubeola. See measles scopolamine, 32, 172t, 175, 879, 1121t, 1400t escitalopram, 244t, 260t, 263
Rubraca. See rucaparib scurvy, 824, 1131 fluoxetine. See fluoxetine
rucaparib, 1064t seasonal affective disorder, 255, 258, 265 fluvoxamine, 243, 244t, 260, 263
rufinamide, 335t, 341t, 352 seasonal allergic rhinitis, 812, 817, 822 paroxetine. See paroxetine
Rythmol/Rythmol SR. Seasonale, 1292 sertraline. See sertraline
Seasonique, 1292 history of, 259
See propafenone sebaceous glands, 1365–1366 for irritable bowel syndrome, 1117
Ryzolt. See tramadol seborrhea, 1370 lactation risk categories, 106t
seborrheic dermatitis, 1138, 1377, 1378 for migraine prophylaxis, 417
S secobarbital, 246t, 247 during pregnancy, 102t
Seconal. See secobarbital pregnancy category, 102t
Sabril. See vigabatrin second messenger events, 50 selegiline, 260t, 271, 309t, 313, 407
saccharin, 1171 secondary hypertension, 583. See also hypertension selenium, 93t, 1141t
sacubitril with valsartan, 629t secondary parkinsonism, 306 Selzentry. See maraviroc
safety. See Patient Safety second-generation (atypical) semielemental formulas, for enteral
safflower oil, 1150 nutrition, 1149
Saizen. See somatropin antipsychotics Semprex-D, 817
Salagen. See pilocarpine
Salex. See salicylic acid
salicylates, 60t, 725–730. See also aspirin

adverse effects, 726–727, 730
doses and routes, 727t

Index  1523

senna, 1105t, 1106 silymarin, 88t sodium
Senokot. See senna Simcor, 20, 502 in antacids, 1094
Sensipar. See cinacalcet simeprevir, 987t, 990, 991 as fluid replacement agent, 534
Sensorcaine. See bupivacaine simple partial seizures, 335–336 functions and recommended dietary
sentinel events, 71 Simplesse, 1171 allowance, 1121t
sepsis, 1155t Simponi. See golimumab imbalances, 541–543, 541t, 543f
Septocaine. See articaine Simulect. See basiliximab
Septra. See trimethoprim-sulfamethoxazole simvastatin sodium bicarbonate
Serax. See oxazepam adverse effects, 574
Serevent. See salmeterol adverse effects, 664t clinical applications, 572, 573–574
SERMs. See selective estrogen receptor chemical structure of, 496 drug interactions, 64, 5574, 576–577
ezetimibe and, 502 Nursing Responsibilities, 574
modulators interactions with, 457t as overdose treatment, 39, 1426t
Seromycin. See cycloserine niacin and, 1054 routes and dosages, 1095t
Serophene. See clomiphene pregnancy category rating, 499
Seroquel/Seroquel XR. See quetiapine fumarate routes and dosages, 497t sodium biphosphate, 1105t
Serostim. See somatropin sitagliptin with, 1221 sodium channel blockers, 647f, 649t, 650
serotonin Sinemet/Sinemet SR. See levodopa/carbidopa
Sinequan. See doxepin class IA
actions and effects of, 259 Singulair. See montelukast disopyramide, 648t, 650
in appetite control, 1164 sinoatrial (SA) node, 479, 481f, 512, 631, 645 procainamide, 648t, 650, 650
effects and clinical applications, 147t, 221t sinoatrial node dysfunction, 645 quinidine gluconate, 648t, 958
in migraines, 364 sinus bradycardia, 645 quinidine sulfate, 648t
synapses, 221 sinus rhythm, 479
serotonin (5-HT) agonists, 414–415. See also sipuleucel-T, 1067t, 1068 class IB
sirolimus, 664t, 749t, 751–753 lidocaine. See lidocaine
ergot alkaloids; triptans Sirturo. See bedaquiline mexiletine, 411, 648t, 651
serotonin (5-HT) antagonists, 1117, 1120, sitagliptin, 1214t, 1215t, 1221–1222 phenytoin. See phenytoin
situational anxiety, 229
1121t, 1122 6-MP. See mercaptopurine class IC
alosetron, 1121t, 1117 Sjögren’s syndrome, 159, 160 flecainide, 648t, 652
dolasetron, 1120, 1121t, 1122 SJS (Stevens–Johnson syndrome), 56, 209, 246, propafenone, 648t, 651–652, 670t
granisetron, 1120, 1121t, 1122
ondansetron. See ondansetron 277, 343, 385, 734, 942 mechanism of action, 647f, 649
palonosetron, 1120, 1121t, 1122 Skelaxin. See metaxalone sodium chloride (NaCl), 551
serotonin syndrome (SES), 261, 262, 264, 266 skeletal muscle relaxants. See muscle sodium ion channel inhibitors, 511
serotonin-norepinephrine reuptake
relaxants amiloride, 545, 550, 552t
inhibitors (SNRIs), 245, 263 skeletal muscle toxicity, 60t, 62 triamterene, 545, 550, 552t, 588t, 589
desvenlafaxine, 260t, 263, 265 Skelid. See tiludronate sodium nitroprusside. See nitroprusside
duloxetine, 244t, 245, 260t, 263, 264, 411 skin. See also dermatologic disorders
venlafaxine. See venlafaxine sodium
Serpalan. See reserpine anatomy of, 1365–1367, 1366f sodium oxybate, 234, 379t, 384, 385, 453
Serratia, 837t bacteria population on, 728t sodium stibogluconate, 960t, 964, 965
sertraline as body defense, 726–727 sofosbuvir, 987t, 989, 990, 991
adverse effects, 263 cancer, 1022 Solarcaine. See benzocaine
clinical applications, 245, 260t, 263 dermatologic toxicity, 60t, 61 solifenacin, 172t
interactions with, 457t infections, 1367–1368 Soliris. See eculizumab
routes and dosages, 244 Sklice. See ivermectin Solodyn. See minocycline
Sertürner, Friedrich, 3 Skyla, 1297 solubility, impact on distribution, 35
serum, 476–477 sleep. See also sleep disorders soluble films, 31
serum glucose control, 1201–1202. See also cardiovascular disease and, 606t Solu-Cortef. See hydrocortisone
diabetes and, 297t Solu-Medrol. See methylprednisolone
diabetes mellitus stages of, 231–233, 232t Soma. See carisoprodol
Serzone. See nefazodone sleep apnea, 233t soman, 1415t
SES (serotonin syndrome), 261, 262, 264, sleep attacks, 312, 384 somatic nervous system, 143, 144f
sleep disorders. See also insomnia somatic pain, 394
266, 407 narcolepsy, 233, 384–385 somatostatin, 1083
sevoflurane, 432, 432t, 433 Nursing Practice Applications, 248–249t somatotropin. See growth hormone
sexual dysfunction. See male sexual prevalence of, 231 somatropin, 1186–1189, 1187t
types of, 231–234, 233t Somatuline Depot. See lanreotide
dysfunction sleep paralysis, 384 Somavert. See pegvisomant
Sherley Amendment of 1912, 15 sleeping sickness (African trypanosomiasis), 963 Sominex. See diphenhydramine
Shigella, 837t sleep-maintenance insomnia, 233 Somogyi phenomenon, 1208
shingles (herpes zoster), 774, 775 977, 1368 sleep-offset insomnia, 233 Sonata. See zaleplon
short stature, defined, 1187 sleep-onset insomnia, 233 sonidegib, 1064t
SIADH (syndrome of inappropriate diuretic sleep-wake patterns, 232, 232t, 233 sorafenib, 1064t
Slow-K. See potassium chloride Soriatane. See acitretin
hormone), 271, 873, 1194 small intestine, 1077, 1078f Sorine. See sotalol
sibutramine, 1166–1167 small volume nebulizers, 790 sotalol, 207t, 210, 648t, 653
sick sinus syndrome, 589, 645 smallpox, 763, 977t, 1414 soundalike drug names, 74, 74t
sickle cell anemia, 698 smoking. See nicotine Sovaldi. See sofosbuvir
side effects, defined, 56. See also adverse drug SNRIs. See serotonin-norepinephrine soy, 87t, 91t, 1233t, 1275t
soybean oil, 1153
effects reuptake inhibitors spacers, 807
Signifor. See pasireotide SNS. See sympathetic nervous system spasms. See muscle spasms
sildenafil, 205, 1317, 1317t, 1318–1319 SNS (Strategic National Stockpile), 1411–1412 spastic colon. See irritable bowel syndrome
Silenor. See doxepin social anxiety disorder, 230, 244 spasticity. See muscle spasticity
silent ischemia, 605 specialty supplements, 92, 93t
Siliq. See brodalumab specific defenses. See adaptive body defenses
silodosin, 203t, 204, 205, 206, 1321t Spectazole. See econazole
Silvadene. See silver sulfadiazine
silver sulfadiazine, 905t, 906, 908

1524 Index steatorrhea, 1125 ethosuximide, 105t, 106t, 335t, 337, 340t,
Stelara. See ustekinumab 347–348
spectinomycin, 880 Stendra. See avanafil
Spectracef. See cefditoren steroids, 467, 489, 490f methsuximide, 340t, 348
spermicides, 1298–1300 sterol nucleus, 489 succinylcholine, 150, 178–180, 362, 367, 430
SPF, 1383 Stevens–Johnson syndrome (SJS), 56, 246, 277, sucralfate, 66t, 1097
spinal anesthesia, 437–438, 439f sucralose, 1171
spinal cord, 222, 223f 385, 906 Sudafed. See pseudoephedrine
spirilla, 837f stevia, 87t, 1171 sudden cardiac arrest (SCA), 656t
Spiriva. See tiotropium Stilbestrol. See diethylstilbestrol Sufenta. See sufentanil
spironolactone Stimate. See desmopressin sufentanil, 404, 424, 425t, 427
stimulant laxatives, 1106 Sugar-Twin. See saccharin
adverse effects, 551, 630, 1315t stimulants. See central nervous system suicide and suicide risk, 257, 268, 274,
breast-feeding and, 105t Sular. See nisoldipine
as diuretic, 550–552 stimulants sulbactam, 850t, 854
for heart failure, 629t, 630 Stivarga. See regorafenib sulconazole, 944t
hydrochlorothiazide and, 545, 587t stomach, 1075–1077, 1083, 1084–1085f sulfa drugs. See sulfonamides
for hypertension, 534–535, 550 stool softeners, 1106 sulfacetamide sodium, 1372t
mechanism of action, 551 Strategic National Stockpile (SNS), 1411–1412 sulfadiazine, 905t, 906, 908
nursing responsibilities, 630 Strattera. See atomoxetine sulfadoxine-pyrimethamine, 905t, 908
routes and dosages, 531t, 550t stratum basale, 1365 sulfamethoxazole. See trimethoprim-
Splenda®. See sucralose stratum corneum, 1365
Sporanox. See itraconazole Streptase. See streptokinase sulfamethoxazole
sporotrichosis, 935, 935t Streptococcus pneumoniae. See pneumococcal Sulfamylon. See mafenide
sporozoites, 954 sulfanilamide, 15
Sportscreme, 1347 infection sulfasalazine
Sprix. See ketorolac Streptococcus pyogenes, 855, 893, 1368, 1404
Sprycel. See dasatinib streptokinase, 680t, 681, 682 adverse effects, 906–907, 1115, 1353
sputum cultures, 918 streptomycin clinical applications, 906–907, 1113, 1115,
SSRIs. See selective serotonin reuptake
adverse effects, 877, 878–879, 921, 925 1350t, 1353
inhibitors clinical applications, 879, 919, 925 Lifespan and Diversity Considerations, 1115
St. John’s wort pregnancy category rating, 102t mechanism of action, 1115
routes and dosages, 877t, 920t Nursing Responsibilities, 1115
for depression, 38, 270t streptozocin, 1038t, 1042 Patient and Family Education, 1115
drug interactions, 5t, 22, 91t, 194, 242, 268 stress ulcers, 1086. See also peptic ulcer disease routes and dosages, 1114t, 1350t
as enzyme inducer, 37 Striant, 1311 sulfinpyrazone, 1346t, 1356, 1358
primary uses, 87t striatum, 307 sulfisoxazole, 105t, 905t, 906–907, 907–908
serotonin syndrome and, 261 Striverdi Respimat. See olodaterol sulfonamides, 904–908
standardization, 88t stroke, 583 adverse effects, 60t, 118, 664t, 906
ST segments, 644t stroke volume, 481–483 classification of, 906–907
stable angina, 605 Stromectol. See ivermectin clinical applications, 902, 904, 906–908, 963
Stadol. See butorphanol stropipate, 1266t drug interactions, 63
staging, of cancer, 1024, 1024t styes, 1401 drugs in class
Stalevo, 309 subcutaneous fungal infections, 936
Staphylococcus aureus subcutaneous layer, of skin, 1365 mafenide, 906
characteristics of, 837t subcutaneous route of administration, 33, 113 silver sulfadiazine, 905t, 906
health-care associated infections and, 842t Sublimaze. See fentanyl sulfacetamide sodium, 906, 1372t
invasiveness of, 835 sublingual route of administration, 31 sulfadiazine, 906t, 906, 907
methicillin-resistant, 842, 842t, 854, 874 Suboxone. See naloxone/buprenorphine sulfadoxine-pyrimethamine, 905t, 907
in skin infections, 1368 substance abuse, 447–437. See also specific sulfasalazine. See sulfasalazine
Staphylococcus saprophyticus, 902 sulfisoxazole, 105t, 905t, 906, 907–908
Starling’s law of the heart, 482 substances trimethoprim, 105t, 664t, 908, 1043
Starlix. See nateglinide addiction and, 394, 449–451 trimethoprim-sulfamethoxazole. See
statins adolescents and, 115–116
adverse effects, 60t, 359, 496, 497t anabolic steroids, 467 trimethoprim-sulfamethoxazole
breast-feeding and, 105t defined, 448 genetic polymorphisms and actions of, 136
for colorectal cancer, 496 dependence and, 401, 449–451 mechanism of action, 839, 904
for dementia, 496 depressants. See central nervous system resistance to, 841, 902, 905
drug interactions, 66, 497, 670t routes and dosages, 905t
drugs in class depressants sulfonylureas, 457t, 906, 1215–1216
diagnosis of, 448 adverse effects, 1215–1216
atorvastatin. See atorvastatin inhalants, 465t, 465 drug interactions, 1216
fluvastatin, 496, 497t, 498 nicotine. See nicotine first generation
lovastatin, 66t, 496, 497t, 498–499, 502 Nursing Practice Applications, 466t
pitavastatin, 496, 497t, 499 during pregnancy, 101–103, 102t chlorpropamide, 60t, 74t, 1193t, 1216
pravastatin, 64, 496, 497t, 499 prescription drugs and, 449 tolazamide, 1193t, 1216
rosuvastatin, 496, 497t, 499 prevalence of, 451t tolbutamide, 1193t, 1216
simvastatin. See simvastatin stimulants. See central nervous system mechanism of action, 1215
for dyslipidemia, 495–496, 497t nursing responsibilities, 1216
mechanism of action, 495-496, 497f stimulants second generation
for pediatric patients, 493t tolerance and, 401, 411, 451–452 glimepiride, 1193t, 1215t, 1216
pregnancy category, 102t withdrawal syndrome and, 450–451, 451t glipizide, 1193t, 1215t, 1216
routes and dosages, 497t substance P, 147t glyburide, 1193t, 1215–1216, 1215t
status asthmaticus, 788 substantia gelatinosa, 395 therapeutic effects and uses, 1215
status epilepticus, 246, 335t, 336, 342, 345 substantia nigra, 307 Sulfoxyl, 1372
stavudine, 1002t, 1005 substrates, 36 sulfur, 1141t
Stavzor. See valproic acid subunit vaccines, 764–765 sulfur mustard, 1415t
Staxyn. See vardenafil Subutex. See buprenorphine sulindac, 731–732t
succinimides, 348 sumatriptan, 112t, 414t, 415–416

Sumavel DosePro. See sumatriptan tachydysrhythmias, 645, 653 Index  1525
Sumycin. See tetracycline tachyphylaxis, 452
sunburns, 1383 tacrine, 37t temazepam, 95t, 238t, 240
Sunett. See acesulfame tacrolimus, 60t, 542t, 749t, 750, 751–752, 1377 Temodar. See temozolomide
sunitinib, 1064t tadalafil, 1317, 1317t, 1318–1319, 1321, 1321t Temovate. See clobetasol propionate
sunscreens, 1383 Taenia saginata, 967 temozolomide, 112t, 1038t, 1041
supercoils, 888 tafluprost, 1395, 1395t temporal lobe seizures. See complex partial
superficial fungal infections, 941, 943, 948 Tagamet. See cimetidine
superinfections, 845–846 Tagrisso. See osimertinib seizures
supplemental nutrition, 1148–1149. See also talc, 1383 temsirolimus, 749t, 752–753
talimogene, 1064t Tenckhoff catheters, 1029
enteral nutrition; parenteral nutrition Taltz. See ixekizumab tendon toxicity, 60t, 62
supplements Talwin. See pentazocine tenecteplase, 680t, 682
Tambocor. See flecainide teniposide, 59t, 889, 1057, 1057t, 1060
dietary. See dietary supplements Tamiflu. See oseltamivir tenofovir
herbal. See herbal supplements tamoxifen
minerals. See minerals adverse effects, 989, 1006
specialty, 93, 93t adverse effects, 59t, 1054 clinical applications, 988, 989, 1004, 1006
vitamins. See vitamin(s) clinical applications, 1024, 1053, 1315, 1343 mechanism of action, 989
Supprelin LA. See histrelin excretion of, 39 Nursing Responsibilities, 990
Suprane. See desflurane interactions with, 670t, 1054 routes and dosages, 987t, 1002t
Suprax. See cefixime mechanism of action, 1053 Tenoretic, 212, 587t
Suprenza. See phentermine Nursing Responsibilities, 1054 Tenormin. See atenolol
suramin, 960t, 963, 965 routes and dosages, 1052t Tensilon. See edrophonium
surface (topical) anesthesia, 435, 436f tamsulosin, 203t, 204, 206, 591, 1321t tension headaches, 413, 413t
surface area, impact on absorption, 34 tanning devices, 1136t, 1372t Tepanil. See diethylpropion
surfactant laxatives, 1106 Tanzeum. See albiglutide teratogens, 60, 103, 104, 345
surgical anesthesia, 424 Tapazole. See methimazole Terazol. See terconazole
Surmontil. See trimipramine tapentadol, 405 terazosin, 202, 203t, 206, 591, 1321, 1321t
sustained release formulations, 30, 31 tapeworms, 967 terbinafine, 937, 943, 944, 944t, 945, 947
Sustiva. See efavirenz Tarceva. See erlotinib terbutaline
Sutent. See sunitinib tardive dyskinesia (TD), 288, 288t as bronchodilator, 195, 196, 793t, 795
suvorexant, 236t, 243 target cells, 1177, 1177f chemical structure of, 188
Svedberg unit, 870 targeted therapies, , 1037, 1064t, 1065 routes and dosages, 1273t
sweat glands, 1365–1366 Targretin. See bexarotene as tocolytic, 196, 1278
Sweet One. See acesulfame Tarka, 518, 531, 587t terconazole, 944t
Sweet’N Low. See saccharin Tasigna. See nilotinib teriflunomide, 322t, 324
swimmer’s ear, 1402 tasimelteon, 236t, 243 teriparatide, 1341t, 1345
Syaxyn. See vardenafil Tasmar. See tolcapone terrorism. See bioterrorism
Sylatron. See pegIFN alfa-2b tavaborole, 944t, 945 tesamorelin, 1004
Symbyax, 261 Tavist. See clemastine Tessalon Perles. See benzonatate
Symlin. See pramlintide taxanes, 1057, 1059 testicular cancer, 1041, 1042, 1050, 1180
Symmetrel. See amantadine cabazitaxel, 1057, 1057t, 1059 Testim, 1310
sympathetic nervous system (SNS) docetaxel, 1057, 1057t, 1059 Testopel, 1310
adrenal medulla and, 149 paclitaxel, 1049, 1057, 1057t, 1059 testosterone. See also androgen(s)
angiotensin II and, 524 Taxol. See paclitaxel adverse effects, 1311
in heart failure, 625 Taxotere. See docetaxel breast-feeding and, 105t
structure and function of, 144–146, 145f tazarotene, 1372t, 1374, 1375, 1380t, 1381 clinical applications, 978, 1310
sympathomimetics. See adrenergic agonists Tazicef. See ceftazidime mechanism of action, 1311
symporter, 545, 545f tazobactam, 857t, 858, 859 Nursing Responsibilities, 1312
Synalar. See fluocinolone acetonide Tazorac. See tazarotene pregnancy category rating, 102t
synapses, 148, 220 Taztia XT. See diltiazem routes and dosages, 31, 1052t,
synaptic cleft, 147 TB. See tuberculosis
synaptic transmission, 146–147f, 146–147, 220, TBG (thyroxine-binding globulin), 1230 1075, 1309t
TBI (traumatic brain injury), 1189t testosterone cypionate, 1309t, 1310
220f, 220t TCAs. See tricyclic antidepressants testosterone enanthate, 1309t
Synarel. See nafarelin TD (tardive dyskinesia), 288t, 288 testosterone undecanoate, 1309t, 1310
syndrome of inappropriate diuretic hormone Tdap. See pertussis immunization Testred. See methyltestosterone
tear gas, 1414 tetanus, 767t, 768
(SIADH), 873, 1194 Tecfidera. See dimethyl fumarate tetanus immune globulin, 777t
Synercid. See quinupristin-dalfopristin Teflaro. See ceftaroline tetanus toxoid, 768
synergistic effects, 65, 65f Tega-Tussin Syrup, 825t tetrabenazine, 363t, 365
Synjardy, 1215t Tegretol/Tegretol XR. See carbamazepine tetracaine, 437t, 439, 1383, 1400t, 1400
Synribo, 1057t Tekamlo, 516 tetracycline
Synthroid. See levothyroxine Tekturna. See aliskiren
syphilis, 837t, 871, 1015t Tekturna HCT, 587t, 590 adverse effects, 118, 873
systemic fungal infections, 936, 938–940, 9380t telaprevir, 1284 clinical applications, 872, 955, 1097
systemic lupus erythematosus, 204t, 596, telavancin, 102t, 860t, 863 distribution of, 35
telbivudine, 987t, 991 drug interactions, 62, 1156
725, 957 telithromycin, 880t, 881, 894t, 895 mechanism of action, 872
systolic heart failure, 623 telmisartan, 516, 531t, 534, 590 nursing responsibilities, 873
telomerase, 1022 routes and dosages, 871t
T telomeres, 1022 for skin infections, 1373
telotristat, 1109t tetracyclines
T cells, 720–721 adverse effects, 66t, 101, 845, 872
T waves, 644, 644f, 644t breast-feeding and, 103t
tablets, 29 clinical applications, 870–872,
Tabloid. See thioguanine
tabun, 1415t 1372t, 1414
drug interactions, 34, 66t, 670t, 1095

1526 Index

tetracyclines (continued) thrombolytics tinea capitis, 935t, 943, 945, 1368
drugs in class adverse effects, 614, 681 tinea corporis, 943, 945
demeclocycline, 871t, 873, 1194 for clot dissolving, 680–681, 684 tinea cruris, 935t, 945, 947, 1368
doxycycline. See doxycycline drugs in class tinea pedis, 935t, 943, 945, 947, 1368
minocycline, 119t, 871t, 873–874, 929 alteplase, 680t, 681, tinea unguium, 945, 1368
tetracycline. See tetracycline reteplase, 680t, 682 tinidazole, 958, 960t, 962
tigecycline, 871t, 874 streptokinase, 680t, 682 tinzaparin, 667
mechanism of action, 838, 872 tenecteplase, 680t, 682 tioconazole, 944t
Nursing Practice Applications, 882–883t in geriatric patients, 680 tiotropium, 172t, 175, 793t, 795, 796–797
pregnancy category, 102, 102t mechanism of action, 647t, 681 tipiracil, 1044t
resistance to, 839, 871, 872 for myocardial infarction, 614, 615f tipranavir, 1002t, 1009–1010
routes and dosages, 871t Nursing Practice Applications, 682–683t tirofiban, 675t, 679
routes and dosages, 680t titanium dioxide, 1383
tetrahydrocannabinol (THC), 458 Titralac. See calcium carbonate
tetrahydrozoline, 192, 194, 822t, 1400t thrombopoietin, 476, 700 Tivicay. See dolutegravir
Teveten. See eprosartan thrush, 935, 935t tizanidine, 363t, 365
Teveten HCT, 533, 587t Thymoglobulin. See antithymocyte globulin TLCs (therapeutic lifestyle changes),
6-TG. See thioguanine Thyro-Block. See potassium iodide
thalamotomy, 308, 308t thyroid cancer, 1021t 493–494, 605
thalamus, 222, 223f thyroid crisis (thyroid storm), 1231, 1231t, 1237 TMP-SMZ. See trimethoprim-sulfamethoxazole
thalassemia, 1140 thyroid disorders TMS (transcranial magnetic stimulation), 258
thalidomide TNF. See tumor necrosis factor (TNF)
diagnosis of, 1231, 1231t
adverse effects, 15, 102 emergencies, 1232–1233, 1233t inhibitors
clinical applications, 1065 hyperthyroidism, 1237–1240, 1238t TNKase. See tenecteplase
pregnancy category rating, 102, 103t hypothyroidism, , 1232–1235, 1234t tobacco use. See nicotine
routes and dosages, 1067t Nursing Practice Applications, 1235–1236t, tobramycin, 877t, 880
Thalomid. See thalidomide Tobrex. See tobramycin
THC (tetrahydrocannabinol), 458 1240–1241t tocainide, 440
theobromine, 386 signs and symptoms of, 1232t tocilizumab, 756t, 1350t, 1353
Theo-Dur. See theophylline thyroid gland, 1230, 1231f, 1231t tocolytics, 196, 1277
theophylline, 386, 387, 793t, 802 thyroid hormone, 103t, 665t, 1180–1181,
TheraCys. See bacillus Calmette-Guérin vaccine magnesium sulfate (MgSO4), 333, 573–574,
therapeutic classification, 6, 6t 1181t, 1230 1108, 1273t, 1277
therapeutic drug monitoring, 40 thyroid hormone replacement, 1232–1235,
therapeutic index (TI), 47, 47f nifedipine. See nifedipine
493–494, 605 1234t, 1235t ritodrine, 1277
therapeutic range, 40 thyroid storm. See thyroid crisis terbutaline. See terbutaline
Thermazene. See silver sulfadiazine Thyroid USP. See desiccated thyroid toddlers, 114–115. See also pediatric patients
thiamine (vitamin B1), 1132–1133t, 1137–1138 thyroid-stimulating hormone (TSH), 1231 tofacitinib, 756t, 1353t
thiazide diuretics thyroid-stimulating immunoglobulins Tofranil. See imipramine
adverse effects, 549, 589, 1315t Tofranil PM. See imipramine pamoate
clinical applications, 549, 548–549 (TSI), 1237 tolazamide, 1214t, 1216
drug interactions, , 907 Thyrolar. See liotrix tolbutamide, 1214t, 1216
drugs in class thyrotoxicosis, 1237 tolcapone, 309t, 313
thyrotropin-releasing hormone (TRH), 1179, Tolectin. See tolmetin
bendroflumethiazide and nadolol, 548t, tolerance, 381, 393, 451–452
550, 587t 1180, 1184, 1230 Tolinase. See tolazamide
thyrotropin-stimulating hormone (TSH), 1231 tolmetin, 731–732t
chlorothiazide, 548t 549, 550, 589 thyroxine (T4), 95t, 1230 tolnaftate, 944t, 1402
chlorthalidone, 202, 548t, 550, 587t, 589 thyroxine-binding globulin (TBG), 1230 tolterodine tartrate, 112t, 172t, 175
hydrochlorothiazide. See TI (therapeutic index), 47, 47f tolvaptan, 570, 1194
tiagabine, 334, 335t, 341t, 352 tonic–clonic seizures, 334, 336, 339, 347
hydrochlorothiazide Tiazac. See diltiazem tonicity, 562–564
indapamide, , 548t, 550, 589 ticagrelor, 675t, 677 tonometry, 1392
methyclothiazide, 548t, 550, 589 ticarcillin, 850t, 851, 852, Topamax. See topiramate
metolazone, 548, 548t, 550, 589 Tice. See bacillus Calmette-Guérin vaccine topical (surface) anesthesia, 435
mechanism of action, 543, 544f, 549 Ticlid. See ticlopidine topical route of administration, 31, 947
routes and dosages, 548t ticlopidine, 616, , 675t, 676, 677–678 Topicort. See desoximetasone
thiazolidinediones (TZDs), 1219–1220 ticonazole, 944t topiramate
pioglitazone, 1215t, , 1216, 1219-1220 Tigan. See trimethobenzamide adverse effects, 341
rosiglitazone, , 1215t, 1216, 1219 tigecycline, 871t, 872-873 in combination products, 1169
thioguanine, 1044t, 1047 TiIV (trivalent inactivated influenza mechanism of action, 332
thiopental sodium, 429 for migraine prophylaxis, 417t
thioridazine, 289, 289t, 291 vaccine), 772 phentermine with, 1067t
thiotepa, 1038t, 1042-1043 Tikosyn. See dofetilide for seizures, 277, 335t, 338, 350, 352
thiothixene, 289t, 293 Tilade. See nedocromil topoisomerase II (DNA gyrase), 888
thirst center, 563 tiludronate, 1339–1340t, 1341 topoisomerase inhibitors, 1056–1059
Thorazine. See chlorpromazine Timentin, 850t, 854 etoposide, 59t, 889, 1057, 1057t, 1059–1060
Three Mile Island nuclear accident (1979), 1415t time-response relationships, 39–42, 41f irinotecan, 112t, 1057, 1057t, 1060
3TC. See lamivudine Timolide, 609t teniposide, , 59t, 889, 1057, 1057t, 1059–1060
threshold potential, 643 timolol topotecan, 1057, 1057t, 1060
thrombin, 478, 670t topoisomerase IV, 888
thrombin, topical, 670 adverse effects, 210, 1397 topotecan, 1057, 1057t, 1060
Thrombinar. See thrombin, topical clinical applications, 210, 629t, 1396-1397 Toprol/Toprol XL. See metoprolol
thrombocytes. See platelets in combination products, 609t, 1396 Toradol. See ketorolac
thrombocytopenia, 476, 662, 662t, 700, 1029 mechanism of action, 1397 toremifene, 1052t, 1054–1055
thromboembolic disorders, 662 Nursing Responsibilities, 1397
routes and dosages, 207t, 1394t
Timoptic/Timoptic XE. See timolol
Tinactin. See tolnaftate
Tindamax. See tinidazole

Index  1527

Torisel. See temsirolimus medication refusal on religious grounds, 135t clinical applications, 902, 905,
torsades de pointes, 645, 654–655 post-traumatic epilepsy in veterans, 345t 907–908
torsemide, 545t, 547, 548, 629t, propranolol sensitivity in Asian
tositumomab, 1065 lactation risk categories, 105t
total parenteral nutrition (TPN), 1152, 1153. patients, 652t mechanism of action, 907
responses to medications, 40t nursing responsibilities, 907
See also parenteral nutrition skin reactions, 1378t patient safety and, 906t
Totect. See dexrazoxane succinylcholine, 180 resistance to, 902, 905
Tourette’s syndrome, 176, 289 vitamins during pregnancy, 1134t routes and dosages, 119t, 905t
Toviaz. See fesoterodine weight loss and diabetes treatment, 1168t synergistic effects of, 65
toxic concentrations, 40 Trecator-SC. See ethionamide trimetrexate, 1043
toxoid vaccines, 765, 1413t Trelstar. See triptorelin trimipramine, 260t, 269
toxoids, 764t, 765 Tremfya. See guselkumab Trimox. See amoxicillin
Toxoplasma gondii, 904, 953t, 962, 1015t tremors, in Parkinson’s disease, 306, 310 Tri-Norinyl-28, 1291t
toxoplasmosis, 953t, 962 Trental. See pentoxifylline Triostat. See liothyronine
TPN (total parenteral nutrition), 1152, 1153. Treponema pallidum. See syphilis Tri-pak. See azithromycin
tretinoin, 1372t, 1373–1375 triprolidine, 815t
See also parenteral nutrition Trexall. See methotrexate triptans, 414–416, 414t
trace minerals. See microminerals Treximet. See sumatriptan triptorelin, 1052t, 1056
Tracrium. See atracurium TRH (thyrotropin-releasing hormone), 1178, Trisenox. See arsenic trioxide
trade name drugs, 8, 9 trivalent inactivated influenza vaccine
Tradjenta. See linagliptin 1179, 1185, 1230
tramadol, 74t, 406, 406t, 407, 1347 triamcinolone, 818t, 1252t, 1378t (TiIV), 772
Trandate. See labetalol Triaminic, 815t Trivora-28, 1291t
trandolapril, 528t, 530–531, 587t, 590 Triaminic Expectorant DH, 825t Trizivir, 1003t
tranexamic acid, 684, 684t, 685, 686 triamterene, 545, 550, 550t, 552, 587t, 589 Trobicin. See spectinomycin
tranquilizers, 236, 286–287. See also triazolam, 236–238t, 240–241 Trokendi XR. See topiramate
triazoles, 941 trophozoite stage, 959
barbiturates; benzodiazepines; Tribenzor, 516, 543, 587t tropic hormones, 1185
nonbenzodiazepine anxiolytics Trichomonas vaginalis, 953t, 961 Tropicacyl. See tropicamide
transcranial magnetic stimulation (TMS), 258 trichomoniasis, 953t, 962–963 tropicamide, 172t, 175, 1400t
transdermal patches, 31 Trichophyton, 945 Trovan. See trovafloxacin
Transderm-Scop. See scopolamine TriCor. See fenofibrate Trulance. See plecanatide
transferrin, 703 Tricosal. See choline magnesium trisalicylate Trulicity. See dulaglutide
transfusions tricyclic antidepressants (TCAs) Truphylline. See aminophylline
blood products, 564–565, 564t Trusopt. See dorzolamide
fluid. See fluid replacement agents for ADHD, 377 Truvada, 990
transient ischemic attacks, 584 as adjuvant analgesics, 408, 408–409t Truvia. See stevia
translation. See protein synthesis advantages of, 267 Trypanosoma brucei, 953t, 963
transplant rejection, 743, 747–748, 750–753, adverse effects, 267, 269, 382, 1315t Trypanosoma cruzi, 953t, 963
1254–1255 for anxiety disorders, 245, 244t trypanosomiasis, 953t, 962–963
Tranxene. See clorazepate breast-feeding and, 105t TSH (thyroid-stimulating hormone), 1231
tranylcypromine, 272 for cataplexy, 234 TSH (thyrotropin-stimulating
trastuzumab, 1064t, 1065 for depression, 244t, 245
Trasylol. See aprotinin drug interactions, 91t, 246 hormone), 1230
traumatic brain injury (TBI), 1189t drugs in class TSI (thyroid-stimulating
Travatan. See travoprost
traveler’s diarrhea, 870t amitriptyline. See amitriptyline immunoglobulins), 1237
travoprost, 1393–1395, 1394t clomipramine, 244t, 245, 260t, 269 T-type calcium channels, 512
trazodone, 74t, 91t, 260t, 266, 1315t desipramine, 240t, , 260t, 267, 268, 382, 1117 tubercles, 917
Treanda. See bendamustine doxepin. See doxepin tuberculin skin tests, 918
Treating the Diverse Patient. See also Lifespan imipramine. See imipramine tuberculoid leprosy, 929
and Diversity Considerations maprotiline, 267, 260t, 269 tuberculosis (TB), 916–928
antihypertensive response, ethnic differences nortriptyline, 244t, 260t, 269, 382
in, 207t protriptyline, 267, 260t, 269, 417t in chemoprophylaxis patients, 921–922
attention deficit/hyperactivity disorder in trimipramine, 260t, 269 diagnosis of, 918
girls, 377t in geriatric patients, 129t in HIV/AIDS patients, 916, 919
cognitive dysfunction after noncardiac for irritable bowel syndrome, 1117 inflammation from, 724
surgery, 436t mechanism of action, 267, 269f multidrug-resistant, 921t, 924, 925
corticosteroid use by mothers at risk for for migraine prophylaxis, 416, 417t Nursing Practice Applications,
preterm labor, 1254t overdose/poisoning, 1416, 1416t
debrisoquin hydroxylase, 137t Triesence. See triamcinolone 927–928t
drug and alcohol abuse, 451t trifluoperazine, 289t, 291 pathogenesis of, 837t, 916, 917f
enzyme deficiencies, 52t trifluridine, 980, 980t, 982, 1044, 1044t pharmacotherapy, 918–928
ethnic differences in acetaminophen Triglide. See fenofibrate
metabolism, 731t triglycerides, 489, 492f adherence issues, 918, 921t
gender differences in desmopressin dose for trihexyphenidyl, 172t, 175, 314, 314t, 315, 325 combination therapy, 918, 919f, 924
nocturia, 1187t tri-iodothyronine (T3), 1230 first-line drugs, 918–919, 920t, 921–925
global health implications of H.Pylori Trilafon. See perphenazine in HIV/AIDS patients, 921t
infection, 1088 Trileptal. See oxcarbazepine mechanisms of action, 838
growth hormone in HIV/AIDS patients on Trilipix. See fenofibric acid prophylactic therapy, 918
antiretroviral therapy, 1180t Trilisate. See choline magnesium trisalicylate regimens, 918, 919, 921
improved kidney function from thyroid trimethobenzamide, 312, 1121t routes and dosages, 920t
hormone replacement, 1235t trimethoprim, 105t, 664t, 905, 907, 908 second-line agents, 920t, 925, 928
lithium carbonate, 274 trimethoprim-sulfamethoxazole pregnancy and, 921
male birth control pills, 1299t absorption of, 906 prevalence of, 916, 917t
adverse effects, 906–907 travel and risk of, 921t
tubocurarine, 180, 370
Tudorza Pressair. See aclidinium
tularemia, 889, 1413

1528 Index urinary retention, 159–160, 167, 401 shingles, 774, 977t
urinary system toxicity, 1031 smallpox, 1414
tumor necrosis factor (TNF) inhibitors, urinary tract infections (UTIs), 900–910 tetanus, 768
718t, 114, 1349 types of, 764–765, 764t
acute uncomplicated, 902, 902t varicella zoster virus, 774–775
adalimumab. See adalimumab complicated, 902t, 902–903 viral, 769–775
certolizumab pegol, 756t, 1349 gender differences in, 901, 902t Vaccine Adverse Event Reporting System
etanercept. See etanercept in geriatric patients, 902t, 903
golimumab, 756t, 1349 Nursing Practice Applications, 910–911t (VAERS), 766
infliximab. See infliximab pathogens causing, 835 vaccine-associated paralytic polio (VAPP), 774
tumors, classification and naming of, 1021, pathophysiology of, 901 vagal nerve stimulators, 334
in pediatric patients, 903 vaginal route of administration, 32
1021t. See also cancer pharmacotherapy, 901–904 Vagistat-1, 944t, 946
Tums. See calcium carbonate vagus nerve stimulation (VNS), 258, 258t
Tussionex, 825t fluoroquinolones, 902–903 valacyclovir, 979, 980t, 982
Twinrix, 771, 988 sulfonamides. See sulfonamides Valcyte. See valganciclovir
Twynsta, 516, 534 urinary antiseptics, 908–910, 909t valdecoxib, 733
Tygacil. See tigecycline during pregnancy, 903 valerian, 87t, 90, 91t, 235
Tykerb. See lapatinib prevalence of, 901 Valeriana officinalis. See valerian
Tylenol. See acetaminophen recurring, 904 valganciclovir, 74t, 980t, 982
Tymlos. See abaloparatide urofollitropin, 1279t Valisone. See betamethasone valerate
tympanic membrane, 1402 uropathogens, 901, 902t Valium. See diazepam
type 1 diabetes, 1202–1203, 1203t. See also Uroxatral. See alfuzosin valproate. See valproic acid
urticaria, 61, 815, 1367 valproic acid
diabetes mellitus U.S. Food and Drug Administration. See Food
type 2 diabetes, 1202–1203, 1203t See also adverse effects, 276, 350, 664t
and Drug Administration for bipolar disorder, 276, 277
diabetes mellitus USP (United States Pharmacopeia), 16t, 17 breast-feeding and, 105t
typhus, 871 USP-NF (United States Pharmacopeia-National clinical applications, 241
tyramine, 269, 270t, 271 drug interactions, 229, 247, 350
tyrosine kinase inhibitors, 1065 Formulary), 16t, 17 mechanism of action, 350
ustekinumab, 1380t, 1382 for migraine prophylaxis, 417, 417t
crizotinib, 1064t, 1065 uterine cancer, 1269 for neuropathic pain, 417
dasatinib, 1064t, 1065 uterine relaxants. See tocolytics nursing responsibilities, 350
imatinib, 1064t, 1065 uterine stimulants, 1273–1277, 1273t pregnancy category, 102t
Tysabri. See natalizumab protein binding in, 334
Tyzeka. See telbivudine egot alkaloids routes and dosages, 118t, 275t
Tyzine. See tetrahydrozoline methylergonovine, 1273, 1273t, 1275 for seizures, 335t, 336, 341t, 349–350
TZDs. See thiazolidinediones valsartan, 516, 531t, 534, 587t, 590, 626, 629t
oxytocin. See oxytocin Valstar. See valrubicin
U prostaglandins Valtrex. See valacyclovir
Vancocin. See vancomycin
ulcerative colitis. See inflammatory bowel carboprost, 1273, 1273t, 1275, 1301, 1302t vancomycin, 40, 664t, 838, 838t,
disease dinoprostone, 1273, 1273t, 1275, 1301, 1302t
misoprostol. See misoprostol 842–843, 853, 854, 859, 860,
ulcers. See peptic ulcer disease Uticort. See betamethasone benzoate 862–863, 879
ulipristal, 1300, 1301t UTIs. See urinary tract infections vancomycin-resistant enterococci (VRE),
Uloric. See febuxostat 842–843
Ultane. See sevoflurane V vandetanib, 1064t
Ultiva. See remifentanil Vantas. See histrelin
Ultracet, 407 V agents, 1415t Vantin. See cefpodoxime
Ultram. See tramadol vaccination, defined, 763 VAPP (vaccine-associated paralytic polio), 774
Ultravate. See halobetasolol vaccine(s), 762–780 VAQTA. See hepatitis A vaccine
ultraviolet light therapy, 1331 vardenafil, 1317, 1317t, 1319
umeclidinium, 793t administration principles, 765–766 varenicline, 464–465
Unasyn, 850t, 854 adverse effects, 765 varicella zoster immune globulin, 777t
undecylenic acid, 944t, 1368 anthrax, 764, 1412–1413 varicella zoster virus (VZV), 743, 774, 979
Uniretic, 530, 587t bacillus Calmette-Guérin, 744t, 646, 747 variola virus, 1414
Unisom. See diphenhydramine bacterial, 765–768 Varivax, 774–775
United States Adopted Name Council, 7 chickenpox, 774–775 vascular disease, diabetes and, 1206–1207
United States Pharmacopeia (USP), 17, 90 diphtheria, 766 vascular endothelial growth factor
United States Pharmacopeia-National Formulary discovery of, 763 (VEGF) inhibitors, 1065
disease epidemiology, 767t bevacizumab, 1064t, 1065
(USP-NF), 17 hepatitis A, 771, 985, 986 ramucirumab, 1064t, 1065
Unithroid. See levothyroxine hepatitis B, 686, 769–771, 769–770, 771 vascular headache. See migraines
Unituxin. See dinutuximab for HIV/AIDS patients, 764 Vaseretic, 530, 587t
Univasc. See moexipril human papillomavirus, 775–776 vasoconstrictors, ocular. See ocular
unlabeled indications, 5 immune globulin preparations, 776–777, 777t decongestants/vasoconstrictors
unstable angina, 605 immune system and, 763–764 vasodilators
up-regulation, 1177 influenza, 771–772 adverse effects, 592–593
urea, 541t, 542, 543 measles, 772–773 drugs in class
Ureaphil. See urea meningococcal, 769 diazoxide, 596
Urecholine. See bethanechol mumps, 772–773 hydralazine. See hydralazine
urethritis, 901 Nursing Practice Applications, 779–780t minoxidil, 594, 1385
Urex. See methenamine hippurate for pediatric patients, 765 nesiritide, 625, 626, 631t
uric acid inhibitors, 1355. See also colchicine pertussis, 766–767, 768 nitroprusside sodium, 595, 596, 596t
uricosurics, 1357 pneumococcal, 768–769
poliomyelitis, 773–774
probenecid, 1355, 1356t, 1357, 1358 during pregnancy, 768
sulfinpyrazone, 1356t, 1357, 1358 rabies, 772
urinalysis, 542, 878 rotavirus, 776
urinary antiseptics, 902, 909–910 rubella, 772–773
fosfomycin, 860t, 863, 902, 905t, 910
nitrofurantoin, 902, 905t, 909–910

Index  1529

for heart failure, 631 Vfend. See voriconazole role in health and disease, 1131–1132
for hypertension, 592–593 Viadur. See leuprolide toxicity, 1133, 1133t
Nursing Practice Applications, 596–597t Viagra. See sildenafil water-soluble, 1131, 1133t, 1137–1141
vasomotor center, 485 Vibativ. See telavancin vitamin A, 1068, 1132t, 1134
vasopressin, 485, 563, 617, 625, 1187t, 1194. See Viberzi. See eluxadoline vitamin B1 (thiamine), 1132–1133t, 1137–1138
Vibramycin. See doxycycline vitamin B2 (riboflavin), 417t, 1132–1133t, 1138
also antidiuretic hormone Vibrio cholerae. See cholera vitamin B3. See niacin
vasopressors, 205, 291, 617 Victoza. See liraglutide vitamin B6 (pyridoxine), 311, 921, 923, 1132–
vasospastic (Prinzmetal’s) angina, 518, 605 Victrelis. See boceprevir
Vasotec. See enalapril Videx EC. See didanosine 1133t, 1138–1139
Vasotec IV. See enalaprilat vigabatrin, 341t, 352 vitamin B9. See folic acid
Vasoxyl. See methoxamine Vigamox. See moxifloxacin vitamin B12. See cyanocobalamin
Vaughan Williams classification, 646 Viibryd. See vilazodone vitamin C (ascorbic acid)
Vecamyl. See mecamylamine vilazodone, 266
Vectibix. See panitumumab Vimovo, 406 clinical applications, 1140
vectors, 954 Vimpat. See lacosamide as dietary supplement, 824t
vecuronium, 176t, 180–181 vinblastine, 74t, 1025, 1057t, 1059 drug interactions, 93t,
vedolizumab, 1115 vinca alkaloids, 1057, 1057t, 1058 functions of, 1133t
VEGF. See vascular endothelial growth routes and adult dosages for, 1134t
vinblastine, 1057, 1057t, 1058 vitamin D
factor inhibitors vincristine, 74t, 1028, 1031, 1057, 1057t, 1058 functions of, 1132t, 1133–1134, 1134t,
Velban. See vinblastine vinorelbine, 1057, 1057t, 1058
Velcade. See bortezomib vincristine, 60t, 74t, 1004, 1026, 1057–1058, , 1135–1136, 1330–1332
Velosef. See cephradine indoor tanning as source of, 1134t
Veltin, 1372t 1057t, 1070 for metabolic bone disease, 1330–1332,
vemurafenib, 1064t, 1065 vinorelbine, 1057, 1057t, 1058–1059 pathway for activation of, 1330–1332,
Venclexta. See venetoclax Vioxx. See rofecoxib therapeutic effects and uses, 1133–1134
vendor-managed inventory (VMI) packages, Viprostol. See conivaptan vitamin E, 585t, 1132t, 1136
Viracept. See nelfinavir vitamin K, 66, 333, 478, 669, 670t, 1132t,
1412 Viractin. See tetracaine
venetoclax, 1064t viral immunizations, 769–776 1136–1137
venlafaxine viral infections, 975–993. See also vita-Plus E. See vitamin E
Vitrasert. See ganciclovir
adverse effects, 264 specific infections vitreous humor, 1391
clinical applications, 244t, 245, 264, 262, 416 characteristics of, 976, 977f Vivactil. See protriptyline
labeling changes, 112t hepatitis viruses, 989, 985–9992, 986–987t Vivitrol. See naltrexone
mechanism of action, 263, 264 herpes simplex viruses, 980t, 979–982 VLDL (very low-density lipoprotein), 490, 491f
Nursing Responsibilities, 264 HIV/AIDS. See HIV/AIDS VMI (vendor-managed inventory)
routes and dosages, 260t influenza viruses, 982–985, 983t
Venofer. See iron sucrose pharmacotherapy principles, 978–979. See packages, 1412
venous return, 482, 484 VNS (vagus nerve stimulation), 258, 258t
venous thromboembolism (VTE), 662 also antivirals Vogelxo, 1310
venous thrombosis. See deep vein thrombosis replication cycle of, 976–978, 977f volatile liquid anesthetics, 432–433
ventilation, 787–788 types of, 977t vomiting and vomiting center, 1030, 1118–1119.
Ventolin. See albuterol viral labyrinthitis, 1405t
ventricular fibrillation (VF), 344, 368, 617, viral load, 999–1000 See also nausea and vomiting
Viramune. See nevirapine von Willebrand’s disease (vWD), 687
646, 655 Virazole. See ribavirin vorapaxar, 616, 675t, 677
ventricular hypertrophy, 624–625 Viread. See tenofovir voriconazole, 938t, 941, 943
ventricular tachycardia, 344, 551, 645–646 virilization, 1308 vorinostat, 1067t, 1068
VePesid. See etoposide virions, 976–978 vortioxetine, 260t, 263
Veramyst. See fluticasone virologic failure, 1000–1001 VoSol HC. See acetic acid and hydrocortisone
verapamil Viroptic. See trifluridine VoSpire/VoSpire ER. See albuterol
virulence, 835 Votrient. See pazopanib
adverse effects, 517–518 viruses, defined, 976. See also viral infections VRE (vancomycin-resistant enterococci),
for angina pectoris, 515t Visceral leishmaniasis, 963
breast-feeding and, 105t visceral pain, 394 842–843
drug interactions, 209, 212, 295, 518 Visine. See tetrahydrozoline VTE (venous thromboembolism), 662
for dysrhythmias, 515t, 648t, 655 Visine LR. See oxymetazoline vulvovaginal candidiasis (VVC), 941, 945, 946
for hypertension, 514t, 517–518, 589 Visken. See pindolol Vumon. See teniposide
mechanism of action, 517 vismodegib, 102t, 1064t vWD (von Willebrand’s disease), 687
for migraine prophylaxis, 417t Vistaril. See hydroxyzine Vytorin, 504
for muscle spasms, 363 Vistide. See cidofovir Vyvanse. See lisdexamphetamine
nursing responsibilities, 518 Vita-C. See vitamin C VZV (varicella zoster virus), 743, 774, 979
routes and dosages, 515t, 609t vitamin(s), 1130–1141. See also specific vitamins
trandolapril and, 513, 589t deficiencies, 1133 W
Verdeso. See desonide defined, 1131
Verelan. See verapamil fat-soluble, 1131, 1132t, 1131–1133, 1134-1137 waist circumference, 1164–1165, 1168t
Verification Program (USP), 90 functions of, 1131, 1132t warfarin
Vermox. See mebendazole history of, 1131
Versed. See midazolam metabolism, factors impacting, 1133 adverse effects, 667, 668–669
vertigo, 815 Nursing Practice Applications, 1143–1144t breast-feeding and, 105t
very low-density lipoprotein (VLDL), 490, 491f in parenteral nutrition, 1154 clinical applications, 668
Vesanoid. See tretinoin during pregnancy, 102, 1134t drug interactions, 37, 66t, 91t, 127, 385,
VESIcare. See solifenacin prenatal, 102t
vesicants, 1032, 1415 recommended dietary allowances, 1133–1134 668–669, 876, 1054, 1095
Vestra. See reboxetine regulation of, 1115–1116 genetic polymorphisms and actions of,
veterans, post-traumatic epilepsy in, 345t
VF (ventricular fibrillation), 344, 368, 617, 646, 655 136–137
mechanism of action, 664, 668
for myocardial infarction, 616
nursing responsibilities, 669
pregnancy category, 102t
protein binding in, 35

1530 Index

warfarin (continued) Xylocaine. See lidocaine zileuton, 798t, 801
routes and dosages, 665t xylometazoline, 194, 822t Zimulti. See rimonabant
as substrate, 37 Xyrem. See sodium oxybate Zinacef. See cefuroxime
transition to, 668–670 Xyzal. See levocetirizine Zinbryta. See daclizumab
zinc, 1141t, 1143
water-soluble vitamins, 1131, 1133t, 1137–1141. Y zinc oxide, 1383
See also specific vitamins Zinecard. See dexrazoxane
Yasmin, 1291t Zingiber officinale. See ginger
wearing-off effect, 307 Yersinia pestis, 849, 889, 1411t, 1413 Zingo. See lidocaine
weight management, 1165–1167, 1169t, 1171. See Yervoy. See ipilimumab Zioptan. See tafluprost
Yodoxin. See iodoquinol ziprasidone, 275t, 277, 294t, 297
also obesity yohimbe, 204 Zirgan. See ganciclovir
WelChol. See colesevelam Yutopar. See ritodrine Zithromax. See azithromycin
Wellbutrin/Wellbutrin SR/Wellbutrin XL. See ziv-aflibercept, 1064t
Z Zmax. See azithromycin
bupropion Zocor. See simvastatin
Wellferon. See interferon(s), IFN alfa-n 1 zafirlukast, 798t, 801 Zofran. See ondansetron
West syndrome. See infantile spasms Zagam. See sparfloxacin Zoladex. See goserelin
Westcort. See hydrocortisone valerate zaleplon, 236t, 241–242 zoledronate (zoledronic acid), 411, 1340t,
WHI (Women’s Health Initiative), 1272 Zaltrap. See ziv-aflibercept
white blood cells. See leukocytes Zanaflex. See tizanidine 1340, 1341t, 1343
WHO (World Health Organization), 7, 397, zanamivir, 983, 983t, 984–985 Zolinza. See vorinostat
Zanosar. See streptozocin Zollinger-Ellison syndrome (ZES), 1086
1014, 1294 Zantac. See ranitidine zolmitriptan, 74t, 414t, 416
whole blood, 564–566, 564t Zarontin. See ethosuximide Zoloft. See sertraline
whooping cough (pertussis), 766–768 Zaroxolyn. See metolazone zolpidem, 236t, 241, 242
withdrawal syndrome, 450–451 Zarxio. See filgrastim Zolpimist. See zolpidem
women. See gender differences; pregnancy Zebeta. See bisoprolol Zometa. See zoledronate
Women’s Health Initiative (WHI), 1272 Zejula. See niraparib Zomig. See zolmitriptan
Wong-Baker Faces scale, 370t Zelapar. See selegiline Zonalon. See doxepin
World Fellowship for Schizophrenia and Allied Zelboraf. See vemurafenib Zonegran. See zonisamide
Zemplar. See paricalcitol zonisamide, 335t, 341t, 352–353
Disorders, 286 Zemuron. See rocuronium Zontivity. See vorapaxar
World Health Organization (WHO), 7, 397, Zenapax. See daclizumab Zorbtive. See somatropin
Zenpep. See pancrelipase Zorcaine. See articaine
1014, 1294 Zerbaxa. See ceftolozane; tazobactam Zortress. See everolimus
Wycillin. See penicillin(s), penicillin G procaine Zerit. See stavudine Zostavax, 774
ZES (Zollinger-Ellison syndrome), 1086 Zosyn, 850t, 855
X Zestoretic, 529, 587t Zovia 1/50E-28, 1291t
Zestril. See lisinopril Zovirax. See acyclovir
Xalatan. See latanoprost Zetia. See ezetimibe Z-pak. See azithromycin
Xalkori. See crizotinib Zevalin. See ibritumomab Zubsolv. See naloxone/buprenorphine
Xanax/Xanax XR. See alprazolam Ziac, 212, 587t Zuplenz. See ondansetron
xanthine oxidase, 1357 Ziagen. See abacavir Zyban. See bupropion
xanthine oxidase inhibitors. See allopurinol Ziana, 1372t Zydelig. See idelalisib
Xarelto. See rivaroxaban ziconotide, 406t, 407, 408 Zyflo CR. See zileuton
Xeljanz. See tofacitinib zidovudine Zykadia, 1064t
Xeloda. See capecitabine Zyloprim. See allopurinol
Xenazine. See tetrabenazine adverse effects, 1005 Zymar. See gatifloxacin
Xenical. See orlistat clinical applications, 844, Zymaxid. See gatifloxacin
Xeomin. See incobotulinumtoxinA Zyprexa. See olanzapine
Xermelo. See telotristat 1004–1005, 1012 Zyrtec. See cetirizine
xerostomia, 159, 160, 173, 297 interactions with, 66t Zytiga. See abiraterone
Xgen. See denosumab mechanism of action, 839, 1005 Zyvox. See linezolid
Xgeva. See denosumab Nursing Responsibilities, 1005
Xiaflex. See collagenase routes and dosages, 1002t
Xifaxan. See rifaximin Zika virus, 106t
Xolair. See omalizumab
Xopenex. See levalbuterol
Xtandi. See enzalutamide
Xtoro. See finafloxacin

Special Features

Connections: Community-Oriented Practice Pediatric Dyslipidemias and Lipid-Lowering Protozoan and Helminthic Infections 970
Drugs 493 Rheumatoid Arthritis and Osteoarthritis 1353
ACE Inhibitors and Angioedema 528 Seizures 353
Botox: Beyond Wrinkles 369 Postoperative Cognitive Dysfunction and Substance Abuse Disorders 466
CCBs and Effects on Minerals 513 Delirium in the Older Adult After Symptomatic Cough and Cold Relief 827
Diuretics: A Banned Substance? 548 Surgery 436 Systemic Corticosteroids 1255
Effects of Soy Intake 1233 Tetracycline, Macrolide, or Aminoglycoside
Epoetin Alpha for Blood Doping 703 Use of Proton Pump Inhibitors in the Older
Fever in the Patient on Immunosuppressant Adult 1092 Antibiotic 882
Thrombolytics 682
Drugs 749 Connections: Nursing Practice Application Thyroid Hormone Replacement 1235
Food–Drug Interactions 67 Tuberculosis 927
HIV Testing and Counseling 1015 Acne and Related Skin Conditions 1375 Type 2 Diabetes 1223
Home Care of Patients on Total Parenteral Nutrition Adrenergic Agonists 197 Urinary Tract Infection 910
Adrenergic Antagonists 213 Vitamin or Mineral Supplements 1143
Therapy 1156 Androgens 1312
Improper Eyedrop Administration 1401 ACE Inhibitors and ARBs 534 Connections: Patient Safety
Macular Edema in Women on Oral Anticoagulants 672
Antidepressants 272 A Tenfold Error 118
Contraceptives 1293 Antidiuretic Hormone 1196 Adequate Patient History to Avoid Adverse
Maintaining Fluid Balance During Antiemetics 1124
Antifungals 948 Effects 773
Exercise 570 Antihistamines 820 Adverse Reaction to Vaccination 979
Risk from Consuming Sushi and Sashimi 964 Antipsychotics 299 Control of Concentrated Electrolyte Solutions 574
Risks Associated with Drugs for Sleep 234 Antiretrovirals 1011 Incomplete Medication Order 1274
Self-Monitoring Blood Pressure 588 Antithyroid Drugs 1240 Incorrect Insulin Dose 1213
Travel and Tuberculosis Risk 924 Antivirals for Non-HIV Viral Infections 992 Increased Plasma Drug Concentrations 1319
Anxiety or Sleep Disorders 248 Iron Poisoning in Children 704
Connections: Complementary and Alternative Asthma and COPD 804 Levofloxacin (Levaquin) 893
Therapies Benign Prostatic Hyperplasia 1323 Medication Errors and Patient-Controlled
Calcium Channel Blockers 519
Acupuncture 1026 Cancer Chemotherapy 1060 Analgesia 398
Aloe Vera 1383 Central Nervous System Stimulants 387 Medication Errors During Transitions of Care 180
Ascorbic Acid (Vitamin C) 824 Cholinergic Agonists 164 Misunderstood Instructions 628
Coenzyme Q10 500 Cholinergic (Muscarinic) Antagonists 181 Photosensitivity and Antibiotics 872
Cranberry 909 Colony-Stimulating Factors 699 Preventing Interactions 5
Echinacea 754 Direct Vasodilators 596 Prompt Use of the Epinephrine Autoinjector in the
Fish Oils for Inflammation 1249 Diuretics 555
Garlic 676 Dysrhythmias 656 School Setting 192
Ginkgo Biloba for Treatment of Dementia 319 Enteral and Parenteral Nutrition 1156 Proper Inhaler Use by Older Adults 797
Glucosamine and Chondroitin for Erythropoietin 696 Trimethoprim-Sulfamethoxazole (Bactrim,
Estrogen 1267
Osteoarthritis 1348 Fluid and Electrolyte Imbalances 578 Septra) 906
Grape Seed Extract 585 Fluoroquinolones 895
Green Tea and Weight Loss 1168 General Anesthesia 434 Connections: Preparing for Advanced Practice
Hawthorn 533 Glaucoma 1398
Ketogenic Diet 333 Gout 1359 Asthma and Exposure to Fungal Pathogens 937
Melatonin 237 Growth Hormone 1192 Chronic Kidney Disease and Prescribing
Natural Therapies for Migraines 417 Heart Failure 635
Omega-3 Fatty Acids 606 Hormonal Contraceptives 1299 Considerations 546
Probiotics for Diarrhea 1122 Hyperlipidemia 505 Complicated Medication Routines and Older
Saw Palmetto 1322 Immunizations 779
Soy as a Phytoestrogen 1275 Immunomodulators 757 Adults 129
St. John’s Wort for Depression 270 Inflammation and Fever 737 Contraceptive Choices 1296
Insulin 1211 Ingestion of Suspected Poison 116
Connections: Lifespan Considerations Laxatives or Antidiarrheals 1111 Intravenous Acetaminophen—Is It Worth the
Lice or Mite Infestation 1371
Abuse of Volatile Inhalants by Children 465 Local Anesthesia 442 Cost? 735
Antihistamines in Older Adults 816 Migraines 417 Medication Errors 75
Calcium Channel Blockers and Dementia 517 Muscle Spasms and Spasticity 370 Myasthenia Gravis: Future Treatments 166
Corticosteroid Use by Mothers at Risk for Preterm Neurodegenerative Disorders 325 Need for the HPV Vaccine 775
Organic Nitrates for Angina and MI 617 Obesity in Primary Care 1169
Labor 1254 Osteoporosis 1335 Older Adults at Risk for Polyherbacy 92
Cost-Related Medication Nonadherence and Food Otitis 1405 Otitis Media 1404
Oxytocin (Pitocin) 1276 Traumatic Brain Injury and Hormones 1189
Insecurity in Older Adults 21 Pain 408 Treating Childhood Anxiety Disorders 247
Dental Health and Dysrhythmias in the Older Penicillin, Cephalosporin, or Vancomycin Treating GERD 1090
Vitamins During Pregnancy 1134
Adult 646 Antibiotic 863 Zika Virus 106
Diabetes in the School Setting 1211 Peptic Ulcer Disease 1098
Drug Monitoring in the Older Adult 127 Poisoning or Overdose 1421 Connections: Treating the Diverse Patient
Early Diagnosis and Treatment of Psychosis in Progestin 1270
ADHD and Athletics 378
Children 293 Effect of CYP2C19 Genotype on Treatment
Miscarriage Prevention with Anticoagulants 668
Neurotoxicity and Mobility Effects of Outcomes for Cardiovascular Patients 614
Enzyme Deficiencies in Ethnic Populations 52
Chemotherapy on the Older Adult 1053 Ethnic Differences in Acetaminophen
Oropharyngeal Candidiasis in Infants 946
Pain Assessment in the Very Young 396 Metabolism 736

Ethnic Differences in Antihypertensive chloroquine (Aralen) 956 metformin (Glucophage, Glumetza, Others) 1217
Response 207 chlorpromazine 290 methotrexate (MTX, Rheumatrex, Trexall) 1044
cholestyramine (Questran) 500 metoprolol (Lopressor, Toprol XL) 211
Gender Differences in Desmopressin Dose for ciprofloxacin (Cipro) 891 metronidazole (Flagyl) 960
Nocturia in Adults 1195 clomiphene (Clomid, Serophene) 1281 midazolam (Versed) 427
clopidogrel (Plavix) 675 mifepristone (Mifeprex) 1302
Impact of Health Literacy on Heart Failure colchicine (Colcrys) 1356 milrinone (Primacor) 635
Outcomes 634 conjugated estrogens (Cenestin, Enjuvia, modafinil (Provigil) 384
montelukast (Singulair) 800
Improved Kidney Function from Thyroid Hormone Premarin) 1265 morphine sulfate (Astramorph PF, Duramorph RF,
Replacement 1235 cromolyn 799
cyanocobalamin (Nascobal) 708 Others) 402
Medication Refusal for Religious, Moral, or Dietary cyclobenzaprine (Amrix) 363 nifedipine (Adalat CC, Procardia XL) 515
Reasons 135 cyclophosphamide (Cytoxan) 1038 nitrofurantoin (Furadantin) and nitrofurantoin
cyclosporine (Gengraf, Neoral, Sandimmune) 751
Pharmacogenomics: Beyond Designer Drugs 39 dabigatran (Pradaxa) 671 macrocrystals (Macrobid, Macrodantin) 908
Post-Traumatic Epilepsy in Veterans with Traumatic dantrolene (Dantrium, Revonto) 366 nitroglycerin (Nitrostat, Nitro-Bid, Others) 609
dapsone (DDS) 929 nitroprusside sodium (Nitropress) 595
Brain Injury 345 desmopressin (DDAVP, Noctiva, Stimate) 1194 nitrous oxide 430
Role of Genetics in Dermatitis and Psoriasis 1378 dextran 40 (Gentran 40, Others) 567 nonoxynol-9 1298
dextromethorphan (Delsym, Robitussin DM, normal serum albumin (Albuminar, Plasbumin,
Sensitivity of Asian Patients to Propranolol 652
Others) 826 Others) 565
Connections: Using Research in Practice 5% dextrose in water (D5W) 566 nystatin (Nystop) 946
diazepam (Valium) 342 octreotide (Sandostatin) 1190
Anticholinergic Toxicity in Parkinson’s Disease 314 digoxin (Lanoxin, Lanoxicaps) 632 omeprazole (Prilosec) 1090
Assessing Cardiovascular Risk of ADHD dimercaprol (BAL in Oil) 1419 ondansetron (Zofran, Zuplenz) 1123
diphenoxylate with atropine (Lomotil) 1110 oprelvekin (Neumega) 700
Medications 380 disulfiram (Antabuse) 457 orlistat (Alli, Xenical) 1168
Early Exposure to Allergens May Reduce Asthma donepezil (Aricept) 319 oxytocin (Pitocin) 1274
doxorubicin (Adriamycin) 1048 pancrelipase (Creon, Pancreaze, Zenpep) 1126
Risk 795 edetate calcium disodium (Calcium EDTA) 1419 penicillin G 852
Emerging Strategies to Combat Bioterrorism 1417 efavirenz (Sustiva) 1006 permethrin (Acticin, Elimite, Nix) 1369
Fecal Microbiota Transplant 1108 epinephrine (Adrenalin) 190 phenelzine (Nardil) 270
Intrathecal Baclofen to Treat Spastic Cerebral Palsy epoetin alfa (Epogen, Procrit) 693 phenobarbital (Luminal) 246
erythromycin (EryC, Erythrocin, Others) 875 phenylephrine (Neo-Synephrine) 193
in Children 361 estradiol and norethindrone (Ortho-Novum, phenytoin (Dilantin, Phenytek) 344
Malignant Hyperthermia and Anesthetics 430 potassium chloride (KCl) 572
Predicting Bone Loss 1345 Others) 1292 pramipexole (Mirapex) 311
Screening, Brief Intervention, and Referral to ethosuximide (Zarontin) 347 prazosin (Minipress) 205
fentanyl (Sublimaze) 425 procainamide 649
Treatment (SBIRT) 461 ferrous sulfate (Feosol, Feostat, Others) 705 procaine (Novocaine) 438
Seasonal Variations in Resistance to Penicillin 856 fexofenadine (Allegra) 816 propofol (Diprivan) 428
Support for Patients with Multidrug-Resistant filgrastim (Granix, Neupogen, Zarxio) 697 propranolol (Inderal, InnoPran XL) 208
finasteride (Proscar) 1322 propylthiouracil (PTU) 1238
TB 921 fluconazole (Diflucan) 941 pseudoephedrine (Sudafed) 823
Traveler’s Diarrhea 870 fludrocortisone 1257 psyllium mucilloid (Metamucil, Naturacil,
Vitamin D Deficiency and Depression in Older fluoxetine (Prozac) 261
fluticasone (Flonase, Veramyst) 818 Others) 1107
Adults 257 furosemide (Lasix) 546 pyridostigmine (Mestinon, Regonol) 163
gabapentin (Neurontin) 348 pyrimethamine (Daraprim) 964
Weight Gain in Children Prescribed Antipsychotic gemfibrozil (Lopid) 502 raloxifene (Evista) 1343
Drugs 297 gentamicin (Garamycin, Others) 878 ranitidine (Zantac) 1093
glucagon (GlucaGen) 1205 repaglinide (Prandin) 1218
Prototype Drugs glyburide (DiaBeta, Glynase) 1215 Rho(D) immune globulin (RhoGAM) 776
haloperidol (Haldol) 291 risperidone (Risperdal) 293
abciximab (ReoPro) 677 heparin 666 rosiglitazone (Avandia) 1219
acarbose (Precose) 1220 hepatitis B vaccine (Engerix-B, Recombivax HB) 770 sildenafil (Viagra) 1317
acetaminophen (Tylenol) 735 human regular insulin (Humulin R, Novolin R) 1209 sitagliptin (Januvia) 1221
acetazolamide (Diamox) 554 hydralazine 593 sodium bicarbonate 576
activated charcoal (CharcoAid) 1418 hydrochlorothiazide (Microzide) 549 sodium chloride (NaCl) 571
acyclovir (Zovirax) 980 hydrocortisone (Cortef, Solu-Cortef, Others) 1252 somatropin (Genotropin, Humatrope, Norditropin,
adalimumab (Humira) 1350 ibuprofen (Advil, Motrin, Others) 731
albuterol (Proventil HFA, Ventolin HFA, imipenem-cilastatin (Primaxin) 860 Others) 1188
imipramine (Tofranil) 268 spironolactone (Aldactone) 551
VoSpire ER) 792 interferon alfa-2b (Intron A) 743 succinylcholine (Anectine, Quelicin) 178
aldesleukin (Proleukin) 746 interferon beta-1b (Betaseron, Extavia) 322 sulfasalazine (Azulfidine) 1115
alendronate (Fosamax) 1340 ipratropium (Atrovent) 796 sumatriptan (Imitrex, Onzetra) 415
allopurinol (Lopurin, Zyloprim) 1357 isoflurane (Forane) 432 tamoxifen 1053
alteplase (Activase) 681 isoniazid (INH) 922 tenofovir (Vemlidy, Viread) 989
aluminum hydroxide (AlternaGEL, Others) 1095 isoproterenol (Isuprel) 195 testosterone 1311
amantadine (Symmetrel) 984 latanoprost (Xalatan) 1393 tetracycline (Sumycin, Others) 872
aminocaproic acid (Amicar) 684 levodopa and carbidopa (Sinemet, Parcopa) 308 theophylline 802
amiodarone (Pacerone) 653 levothyroxine (Levothroid, Levoxyl, Others) 1233 timolol (Betimol, Timoptic, Others) 1396
ammonium chloride 577 lidocaine (Anestacon, Xylocaine, Zingo, Others) 439 tramadol (Ultram, Others) 406
amphetamine and dextroamphetamine (Adderall, lisinopril (Prinivil, Zestril) 529 tretinoin (Avita, Retin-A, Others) 1373
lithium carbonate (Eskalith, Lithobid) 274 trimethoprim-sulfamethoxazole (Bactrim, Septra) 907
Adderall XR) 380 lopinavir with ritonavir (Kaletra) 1008 valproic acid (Depacon, Depakene, Depakote) 349
amphotericin B deoxycholate (Fungizone) 939 lorazepam (Ativan) 238 vancomycin (Vancocin) 862
ampicillin 854 losartan (Cozaar) 532 varenicline (Chantix) 464
aripiprazole (Abilify) 297 mmaagnnneitsoilu(mOssmuliftartoel)(M55g3SO4 ) 574 venlafaxine (Effexor) 264
aspirin (Acetylsalicylic Acid) 728 mebendazole (Vermox) 968 verapamil (Calan, Isoptin, Verelan) 517
atenolol (Tenormin) 611 medroxyprogesterone (Depo-Provera, Depo-SubQ- vincristine (Marqibo, Oncovin) 1057
atomoxetine (Strattera) 382 warfarin (Coumadin) 669
atorvastatin (Lipitor) 496 Provera, Provera) 1269 zidovudine (Retrovir, AZT) 1004
atropine (Atropen) 174 zolpidem (Ambien, Edluar, Others) 241
azathioprine (Azasan, Imuran) 753
basiliximab (Simulect) 755
beclomethasone (Beconase AQ, Qvar) 797
benzocaine (Americaine, Anbesol, Others) 1384
benztropine (Cogentin) 314
bethanechol (Urecholine) 159
buprenorphine with naloxone (Suboxone,

Zubsolv, Others) 454
caffeine 386
calcitriol (Calcijex, Rocaltrol) 1338
calcium salts 1333
carbamazepine (Carbatrol, Tegretol, Others) 346
cefazolin (Ancef, Kefzol) 858
celecoxib (Celebrex) 734