Research Annual Report 2015

Research Department

Annual
Report

2015
1436-1437

King Khaled Eye Specialist Hospital

Riyadh, Kingdom of Saudi Arabia



Table of Contents i

Foreword – General Executive Director.......................................................... ii/iii

Human Ethics Committee/Institutional Review Board...................................... 3

Research Department
Mission Statement........................................................................................ 21
Research Department Staff ........................................................................... 22.
Clinical Research ......................................................................................... 25.
Resources available to Hospital staff for Clinical Research............................. 27.
Ophthalmic Epidemiology............................................................................ 28.
Disease Registries......................................................................................... 30.
Laboratory................................................................................................... 33.
Resources available to Hospital staff for Laboratory Research........................ 36.
Activities of Research Department................................................................ 37.
Research Website ......................................................................................... 38

Research Projects
Statistics ...................................................................................................... 45.
Completed Projects....................................................................................... 47.
Active Projects Initiated in 2015.................................................................... 57.
Active Projects Initiated before 2015.............................................................. 71.
JHU-KKESH Collaborative Projects............................................................. 94

Publications
Statistics..................................................................................................... 125.
Abstracts of Publications............................................................................ 126

Books and Book Chapters By Medical Staff
Papers........................................................................................................ 233.
Book Chapters & Articles................................................................................ 234

Presentations
Statistics..................................................................................................... 239.
Abstracts of Presentations........................................................................... 242

Appendices:

Index
Biographical............................................................................................... 277.
Acknowledgements..................................................................................... 307

Research Department Annual Report 2015

ii Foreword

It is with great pleasure that we present the 2015 Annual Report of the Research
Department. As the premiere tertiary care eye hospital in the kingdom, the King
Khaled Eye Specialist Hospital continues to strive for excellence in the combined
missions of research, education, and clinical care. This report illustrates the
substantial progress made in the past year, evident through the quality, quantity,
and impact of the publications and presentations produced by the medical staff and
trainees. The research performed at KKESH and with collaborators around the
world continues to improve the prestige and already illustrious reputation of the
hospital in the region and the world.

Always a traditional strength, clinical research continues to be a pillar of excellence
in the department. KKESH was selected to be a key site for a multi-center uveitis
trial sponsored by the United States National Eye Institute/National Institute
of Health; this is the first time a hospital in Saudi Arabia has been awarded this
prestigious opportunity, and patients have already begun enrolling in this important
study. The hospital has also been selected to perform several clinical studies funded
by pharmaceutical and device manufacturing companies, including a promising
glaucoma implant and a simple tool for diabetic retinopathy screening. KKESH
will soon accept the first class of candidates for a new certified Clinical Research
Coordinator training program; the leaders of tomorrow are learning the methods of
research at KKESH today.

The basic and translational scientists continue to build the infrastructure to perform
independent and important research at KKESH; by leveraging local talent and
international collaborations, the laboratory is now performing such techniques
as DNA sequencing, immunohistochemistry, and cell culture. The research team
continues to pursue cutting-edge research that focuses on diseases that are important
to the people of Saudi Arabia, including keratoconus, diabetes, ocular tumors, genetic
and inherited disorders, and glaucoma. Investigators from KKESH have worked
alongside the faculty of Johns Hopkins University to develop several important
discoveries, including new technology in nanomedicine. Additional laboratory space
in the new Al Rajhi Diabetic Eye Centre will allow additional staff and technology
to be added to the growing department.

The progress of 2015 will lay the foundation for much success in the years to
come; continued improvements in the ability of the faculty and trainees to perform
outstanding clinical research, advancements in translational science capabilities, and
an ongoing commitment to excellence will ensure that KKESH will lead the region
into the future.

Abdul Elah Al-Towerki, MD
Senior Academic Consultant
General Executive Director
King Khaled Eye Specialist Hospital

Research Department Annual Report 2015

‫مقدمة‬ ‫‪iii‬‬

‫إنه لمن دواعي السرور أن نقدم تقرير قسم الأبحاث للعام ‪ 2015‬بمستشفى الملك خالد التخصصي للعيون‪ ،‬فبصفته أحد أهم مستشفيات‬
‫العيون للرعاية المتخصصة في المملكة فهو يواصل السعي نحو تحقيق التميز في مسيرته التي تجمع بين الاهتمام بالأبحاث و التعليم‬
‫و الرعاية الصحية‪ .‬و هذا التقرير يوضح التقدم الهائل الذي أحرزه المستشفى في العام الماضي والذي يظهر من خلال الجودة‪ ،‬و الكمية‪،‬‬

‫وأثر المنشورات و العروض التقديمية التي تم إعدادها من قبل الطاقم الطبي و المتدربين‪ .‬فالأبحاث المقدمة من المستشفى و بالتعاون‬
‫مع جهات أخرى في جميع أنحاء العالم لا زالت مستمرة لتحسين مكانة و سمعة المستشفى في المنطقة و العالم‪ ،‬حيث وجدت دراسة‬

‫حديثة أن مستشفى الملك خالد التخصصي للعيون قد نشر ما يقارب ‪ %20‬من الأبحاث في طب العيون من الدول العربية‪ ،‬كما أنه حتى‬
‫الآن يعتبر أكبر ناشري مقالات الأبحاث والإصدارات في مجال طب العيون في العالم العربي‪ .‬و قد نُشرت أبحاث المستشفى في المجلات‬
‫المرموقة و الرائدة بما في ذلك مجلة الطبيعة و مجلة علم الوراثة الطبيعي و المجلة الأمريكية لطب العيون و كذلك المجلة البريطانية‬
‫لطب العيون‪.‬‬

‫و لكون الأبحاث الإكلينيكية تشكل مصدر قوة‪ ،‬فهي لا تزال أحد أهم ركائز التميز في المستشفى‪ ,‬و قد تم اختيار المستشفى ليصبح‬
‫المقر الرئيسي لدراسات التهاب عنبية العين بالتعاون مع عدة مراكز برعاية معهد العيون الوطني و المعهد الوطني للصحة في الولايات‬
‫المتحدة‪ .‬و هذه هي المرة الأولى التي يتم فيها منح مستشفى في المملكة العربية السعودية هذه الفرصة المرموقة‪ ،‬و قد تم كذلك إشراك‬

‫المرضى في هذه الأبحاث المهمة‪ ،‬كما تم اختيار المستشفى أيضا لإجراء العديد من الأبحاث الطبية التي تمولها شركات تصنيع الأدوية و‬
‫الأجهزة بما في ذلك جهاز زراعة لعمليات الجلوكوما‪ ،‬و أداة صغيرة تستخدم لفحص اعتلال الشبكية السكري‪ .‬و قريبا سيقبل المستشفى‬
‫الدفعة الأولى من المرشحين لبرنامج التدريب الجديد لمنسقي الأبحاث الإكلينيكية والمعتمد من الهيئة السعودية للتخصصات الصحية ‪,‬‬

‫وهذا البرنامج سيساعد في تحسين الكفاءة اللازمة لمواصلة المهمة البحثية‪.‬‬

‫و يواصل العلماء المهتمون بالأبحاث الأساسية والأبحاث الإنتاجية مهمتهم في تأسيس البنية التحتية لإجراء أبحاث مستقلة في‬
‫المستشفى من خلال الاستفادة من المواهب المحلية و التعاون الدولي‪ .‬و المختبرات الآن تقوم باجراءاتها بشكل روتيني من خلال القيام‬
‫بتقنيات مثل تسلسل الحمض النووي و تحليل الكيمياء الهيستولوجية المناعية و زراعة الخلايا‪ .‬وواصل فريق الأبحاث إجراء الأبحاث‬

‫المتطورة التي تركز على الأمراض المنتشرة بين السعوديين بما في ذلك القرنية المخروطية و مرض السكري و أورام العين و الاضطرابات‬
‫الوراثية و الجينية و الجلوكوما‪ .‬و قد عمل الباحثون في المستشفى جنبا إلى جنب مع طاقم جامعة جونز هوبكينز وذلك سعيا لتطوير‬
‫عدة اكتشافات هامة بما في ذلك التكنولوجيا الجديدة لطب النانو‪ ,‬وسيتيح المختبر الإضافي الجديد في مركز الراجحي لاعتلال السكري في‬

‫العين ااستقطاب الموظفين الجدد و التكنولوجيا الجديدة للقسم‪.‬‬

‫إن التقدم المحرز في عام ‪ 2015‬سيشكل البنية الأساسية للمزيد من النجاحات في السنوات القادمة كما أن مواصلة تطوير قدرات‬
‫الأطباء والمتدربين في في إجراء الأبحاث الطبية البارزة و إحراز التقدم في العلوم الإنتاجية و كذلك الالتزام المستمر بالتميز سيبقي‬

‫المستشفى في محل الصدارة بالمنطقة في المستقبل‪.‬‬

‫د‪ .‬عبد الإله الطويرقي‬
‫كبير استشاريين اكاديمي‬

‫المدير العام التنفيذي‬
‫مستشفى الملك خالد التخصصي للعيون‬

‫‪Research Department Annual Report 2015‬‬





































































40 Research Department

Research Department Website
http://rd.kkesh.med.sa/
The research website connects the Research Department at KKESH to individuals
and institutions globally.
The website provides information about the department, the annual report,
eye research news, upcoming meetings/symposiums, contact information and
opportunities for collaboration.
This year we have updated the Research website and added new sections for the
end user. These new sections are:

• Research Journal Club
• Publications section have been updated to include all publications for 2015.
• New Dates for IRB submission deadlines and meetings for 2016.

Research Department Annual Report 2015

Research Department 41

Research Department Annual Report 2015



Research Projects



Research Projects 45

Statistics

In 2015, a total of 139 (one hundred and thirty-nine) projects were submitted to the
Research Department. 100 (one hundred and one) projects are currently in progress
and 18 (eighteen) projects have been completed

The submission types are as follows:

Type of Project Number of
Submissions
Prospective
Retrospective 25
Case Report
53
Total Submissions
61

139

In 2015, there wasn’t a big increase in indexed and presentations but an increase
in the non-indexed publication, which demonstrated the continues commitment of
the KKESH Medical Staff to research and worldwide recognition.

Table: Comparison of Research Projects, Publications, and Presentations (2010-2015)

Category of Projects 2010 2011 2012 2013 2014 2015
Approved 56 52 61 101 83 125

Completed 30 25 54 71 31 60

*Publications: 43 60 103 117 109 105
Indexed 33 58 85 115 108 103
Non-indexed 10 02 18 02 01 02

*Presentations 77 92 178 120 161 104

Research Department Annual Report 2015

46 Research Projects

180 Approved
160 Completed
140 Publications
120 Presentations
100
80 2011 2012 2013 2014 2015
60
40
20

0
2010

Research Department Annual Report 2015

Research Projects 47

Completed Projects

The following research projects were all completed during 2015.

The categories of the 60 completed projects are:

Prospective Studies (P) 10
Retrospective Studies (R) 25
Case Reports (CR) 25

2015

1502-CR Case report of Orbital Xanthogranuloma

Principal Investigator: Saif Al-Dossari, MD

Co-Investigator: Hailah Al-Hussain, MD

Hind Al-Katan, MD

Azza Maktabi, MD

1504-CR Specific form of non-arteritic ischemic optic neuropathy in Diabetics.
Evaluation of 6 patients

Principal Investigator: Alberto Galvez, MD

1514-CR Central corneal thinning induced by self application of Alum
substance

Principal Investigator: Huda Al-Ghadeer, MD

Co-Investigator: Mohammed Al-Amry, MD

1516-CR Atypical trigeminal perineural spread

Principal Investigator: Sahar Elkhamary, MD

Co-Investigator: Hind Al-Katan, MD

Patricia Akaishi, MD

Alicia Galindo, MD

Augusto Cruz, MD

1532-CR Infectious crystalline Keratitis post corneal cross-linking for
Keratoconus

Principal Investigator: Mohammed Al-Amry, MD

Tariq Al-Mudhayan, MD

Co-Investigator: Reem Al-Huthail, MD

Mohammed Al-Amro, MD

Huda Al-Ghadeer, MD

Research Department Annual Report 2015

48 Research Projects

1544-CR Candida parapsilosis corneal graft infection from a single eye center:
Histopathologic report of 2 cases

Principal Investigator: Azza Maktabi, MD

Hind Al-Katan, MD

Co-Investigator: Ali Al-Rajhi, MD

Mosa Al-Harby, MD

1552-CR Corneal XZanthogranuloma in association with multiple Endocrine
Neoplasia: A clinicopathologic case report and review of literature

Principal Investigator: Hind Al-Katan, MD

Ali Al-Rajhi, MD

1555-CR Breast adenocarcinoma presenting as orbital metastatic lesion

Principal Investigator: Hind Al-Katan, MD

Co-Investigator: Sahar Elkhamary, MD

1558-Rv Wide and Ultra-wide field retinal imaging

Principal Investigator: Igor Kozak, MD

Co-Investigator: Fernando Arevalo, MD

1569-CR Retinal Dystrophy with hair loss

Principal Investigator: Arif Khan, MD

1571-CR Punctal plugs in a double lacrimal puncta-canaliculus patient with dry
eye

Principal Investigator: Laila Al-Ghefari, MD

Co-Investigator: Alicia Galindo, MD

1573-CR Rare presentation of Dome-shaped Maculopathy in Saudi patient with
long follow-up

Principal Inbvestigator: Adel Al-Akeely, MD

Co-Investigator: Saba Al-Rashaed, MD

1574-CR Retinal hemorrhages after traditional therapy in patients with retinal
dystrophy

Principal Investigator: Inam Bifari, MD

Co-Investigator: Arif Khan, MD

Research Department Annual Report 2015

Research Projects 49

1577-CR Isolated ocular surface squamous neoplasia of the cornea

Principal Investigator: Huda Al-Dhaheri, MD

Co-Investigator: Samar Al-Swailem, MD

Azza Maktabi, MD

1578-CR Lamellar Keratoplasty for traumatic corneal blood staining

Principal Investigator: Abdulrahman Khairallah, MD

Co-Investigator: Omar Kirat, MD

Mosa Al-Harby, MD

1581-CR Orbital involvement in Angiolymphoid Hyperplasia with Eosinophilia

Principal Investigator: Alicia Galindo, MD

Co-Investigator: Sahar Elkhamary, MD

Hind Al-Katan, MD

1582-CR Accidental foveal injury secondary to Alexandrite laser used in
dermatology clinic during hair removal procedure

Principal Investigator: Majed Al-Harbi, MD

Co-Investigator: Yahya Al-Zahrani, MD

15125-CR Central Retinal Vein occlusion in a childhood optic nerve tumor

Principal Investigator: Igor Kozak, MD

Co-Investigator: Sahar Elkhamary, MD

Thomas Bosley, MD

2014

1405-R Description of the clinical characteristics of a historical cohort of
patients with acute optic neuritis

Principal Investigator: Alberto Galvez, MD

Co-Investigator: Sahar El-Khamary, MD

1411-R Visual and anatomical outcome of Nd: YAG laser hyaloidotomy in
management of premacular hemorrhage

Principal Investigator: Maha Al-Shehri, MD

Co-Investigator: Nicola Ghazi, MD

Sawsan Nowilaty, MD

Research Department Annual Report 2015

50 Research Projects

1412-R Five year experience with conjunctival flap as an alternative to fit a
prosthesis

Principal Investigator: Alicia Galindo, MD

Co-Investigator: Patricia Akaishi, MD

Augusto Cruz, MD

1420-R Outcome of cyclophotocoagulation short duration VS long duration

Principal Investigator: Sultan Al-Zuhairy, MD

Co-Investigator: Deepak Edward, MD

Sami Al-Shahwan, MD

Ibrahim Al-Jadaan, MD

Ohoud Owaydha, MD

1424-CR Removal of Retained Descemet’s Membrane by Femtosecond Laser

Principal Investigator: Sultan Al-Rashidi, MD

Co-Investigator: William May, MD

1444-R Clinical feature and surgical outcome in CYP1B1 – related congenital
glaucoma patients

Principal Investigator: Najah Al-Shahrani, MD

Co-Investigator: Arif Khan, MD

1446-R Characterization of congenital retinal dystrophies in Saudi children
(other than Leber congenital anaurosis)

Principal Investigator: Arif Khan, MD

1447-CR Type I Keratoprosthesis in patients with Xeroderma Pigmentosum

Principal Investigator: Abdullah Al-Assiri, MD

Co-Investigator: Abdulrahman Khairallah, MD

1452-P Bottle characteristics of international anti-glaucoma brands & local
KSA brands: A comparative study

Principal Investigator: Nasser Al-Jumaian, MD

Co-Investigator: Deepak Edward, MD

Farhan Al-Enzi, MD

Abdullah Al-Humaidan, PharmD

Rana Al-Madany

Research Department Annual Report 2015