DRUG ALBUM PKDHS 2021

INSULIN DETEMIR 100 IU/ML
INJECTION IN PREFILLED
SYRINGE/CARTRIDGE

CATEGORY DESCRIPTION
PREGNANCY
LACTATION B
SPECIAL COUNSELING POINT
Compatible

May be taken with or without food: For
patients treated w/ once daily regimen,

administer w/ evening meal or at
bedtime. For patients who need bd

dosing, the evening dose can be
administered either w/ evening meal or at

bedtime or 12 hr after morning dose.

137

INSULIN RECOMBINANT NEUTRAL HUMAN
SHORT ACTING 100 IU/ML PENFILL AND
REFILL

CATEGORY DESCRIPTION
PREGNANCY B
LACTATION
SPECIAL COUNSELING POINT Compatible
Should be taken on an empty stomach:

Administer 30 min before meals.

138

INSULIN RECOMBINANT SYNTHETIC HUMAN,
INTERMEDIATE-ACTING 100 IU/ML PENFILL

AND REFILL

CATEGORY DESCRIPTION
PREGNANCY B
LACTATION
SPECIAL COUNSELING POINT Compatible
Monitor for hypersensitivity reaction

139

INSULIN RECOMBINANT SYNTHETIC HUMAN,
PREMIXED 100 IU/ML PENFILL AND REFILL

CATEGORY DESCRIPTION
PREGNANCY B
LACTATION
SPECIAL COUNSELING POINT Compatible
Should be taken on an empty stomach:

Administer 30 min before meals.
Monitor for hypoglycemic reaction.

140

IPRATROPIUM BROMIDE 0.0125%
NEBULISING SOLUTION (125 MCG/ML)

CATEGORY DESCRIPTION
PREGNANCY B
LACTATION
SPECIAL COUNSELING POINT No Human Data
Monitor for hypersensitivity reaction.

141

IPRATROPIUM BROMIDE 0.025%
INHALATION SOLUTION (250 MCG/ML)

CATEGORY DESCRIPTION
PREGNANCY B
LACTATION
SPECIAL COUNSELING POINT No Human Data
Monitor for hypersensitivity reaction.

142

IPRATROPIUM BROMIDE 0.5 MG AND
SALBUTAMOL 2.5MG PER UDV

CATEGORY DESCRIPTION
PREGNANCY
LACTATION C

SPECIAL COUNSELING POINT No Human Data—Probably
Compatible

Monitor for hypersensitivity reaction.
Discontinue if paradoxical
bronchospasm occurs

143

IPRATROPIUM BROMIDE 20 MCG AND
FENOTEROL 50 MCG/DOSE INHALER

CATEGORY DESCRIPTION
PREGNANCY
LACTATION C

SPECIAL COUNSELING POINT No Human Data—Probably
Compatible

Monitor for hypersensitivity reaction.
Discontinue if paradoxical
bronchospasm occurs

144

IRON (III)-HYDROXIDE POLYMALTOSE
COMPLEX (IPC) 100 MG IRON AND 0.35 FOLIC

ACID CHEWABLE TABLET

CATEGORY DESCRIPTION
PREGNANCY
Unassigned - Data from
LACTATION epidemiological studies is not available.
SPECIAL COUNSELING POINT
Animal studies did not show any
reproductive toxicity

It is not known whether iron from the
iron(III)-hydroxide polymaltose complex

is excreted in human milk.

Should be taken with food: Take during
or immediately after meals. May be
chewed or swallowed whole.

145

IRON DEXTRAN 50 MG FE/ML
INJECTION

CATEGORY DESCRIPTION
PREGNANCY
C - Animal data
LACTATION suggest reproductive toxicity. Benefit
SPECIAL COUNSELING POINT
should outweigh risk

It is preferable to not use
during breast-feeding

Monitor for hypersensitivity reaction

146

ISONIAZID 100 MG TABLET

CATEGORY DESCRIPTION
PREGNANCY
LACTATION C - Compatible—Maternal Benefit >>
SPECIAL COUNSELING POINT Embryo–Fetal Risk

Limited Human Data—
Probably Compatible
Monitor for hypersensitivity reaction.

147

ISOSORBIDE DINITRATE 10 MG TABLET

CATEGORY DESCRIPTION
PREGNANCY
LACTATION C - Moderate Risk

SPECIAL COUNSELING POINT No Human Data—Probably
Compatible

This drug may cause dizziness on
standing, sit or lie down before use and
get up gradually to minimise this effect.

148

LABETALOL HCL 100 MG TABLET

CATEGORY DESCRIPTION
PREGNANCY
LACTATION C
SPECIAL COUNSELING
Limited Human Data—Probably Compatible
POINT
• Should be taken with food.

• Instruct patient to take a missed dose as
soon as possible, but if the next dose is in
less than 8h, skip the dose

• May mask hypoglycemia symptoms. Advise
diabetic patient to carefully monitor blood
sugar levels

149

LABETALOL HCL 5 MG/ML INJECTION

CATEGORY DESCRIPTION

PREGNANCY C

LACTATION Limited Human Data—Probably Compatible

SPECIAL COUNSELING • Rise slowly from a siting/supine position, as
POINT drug may cause orthostatic hypotension

• May cause nausea

150

LACTULOSE 3.35 G/5 ML LIQUID

CATEGORY DESCRIPTION

PREGNANCY B

LACTATION No human data- Probably compatible

SPECIAL COUNSELING Lactulose can take up to 48 hours to have an effect.
POINT If the medicine cause the stomach to feel queasy, mix
the dose with some water or fruit juice. Alternatively,
take the medicine with a meal.

151

LEVODOPA 200 MG, BENSERAZIDE 50 MG
TABLET

CATEGORY DESCRIPTION
PREGNANCY
LACTATION C

SPECIAL Since it is not known whether benserazide passes into
COUNSELING breast milk, mothers requiring Madopar treatment should

POINT not nurse their infants, since the occurrence of skeletal
malformations in the infants cannot be excluded

• Absorption is reduced and delayed by food, though it is
usually administered with meal to reduce nausea and
vomiting.

• May discolour saliva, teeth, oral mucosa, or urine a dark red
color

152

LEVONORGESTREL 150 MCG AND
ETHINYLOESTRADIOL 30 MCG TABLET

CATEGORY DESCRIPTION

PREGNANCY X

LACTATION The use of combined oral contraceptive is generally
not recommended until the nursing mother has
SPECIAL COUNSELING completely weaned her child
POINT
• Report persistent/prolonged vaginal bleeding
• Report any unexplained partial or complete vision

loss and patient who wears contact lens to report
visual changes in lens tolerance

153

LEVOTHYROXINE SODIUM 50 MCG
TABLET

CATEGORY DESCRIPTION

PREGNANCY A

LACTATION Compatible

SPECIAL COUNSELING • Improvement of symptoms may not be evident for

POINT several weeks
• Takes 4 hours apart from antacids, iron and calcium

supplements

• Take on empty stomach (30min to 1 hour prior to
breakfast)

154

LEVOTHYROXINE SODIUM 50 MCG
TABLET

CATEGORY DESCRIPTION

PREGNANCY A

LACTATION Compatible

SPECIAL COUNSELING • Improvement of symptoms may not be evident for

POINT several weeks
• Takes 4 hours apart from antacids, iron and calcium

supplements

• Take on empty stomach (30min to 1 hour prior to
breakfast)

155

LIGNOCAINE 2% JELLY

CATEGORY DESCRIPTION

PREGNANCY B

LACTATION Use with caution

SPECIAL COUNSELING • Prolonged use in eyes may lead to severe contact
POINT keratitis & corneal damage.
• Side effects may include application site reactions
such as irritation, erythema, and pruritus

156

LIGNOCAINE HCL (LIDOCAINE) 2%
INJECTION

CATEGORY DESCRIPTION
PREGNANCY B
LACTATION
SPECIAL COUNSELING Limited human data- Probably compatible

POINT May cause temporary loss of sensation and motor
activity.

157

LORAZEPAM 1 MG TABLET

CATEGORY DESCRIPTION

PREGNANCY D

LACTATION Compatible

SPECIAL • Avoid activities requiring coordination until drug effect
COUNSELING POINT are realized as drug may cause somnolence
• Warn female patient to avoid pregnancy during
therapy

158

LOSARTAN 50 MG TABLET

CATEGORY DESCRIPTION
PREGNANCY
LACTATION D

SPECIAL COUNSELING No Human Data—Probably compatible, an
POINT alternate drug may be preferred, especially while

nursing a newborn or preterm infant.

• This drug may occasionally cause dizziness or
drowsiness, if affected, do not drive or operate
machinery.

• Warn female patient to avoid pregnancy and to
report a pregnancy that occurs during therapy

159

LOSARTAN POTASSIUM 100 MG TABLET

CATEGORY DESCRIPTION
PREGNANCY
LACTATION D

SPECIAL COUNSELING No Human Data—Probably Compatible, but an
POINT alternate drug may be preferred, especially while

nursing a newborn or preterm infant.

• This drug may occasionally cause dizziness or
drowsiness, if affected, do not drive or operate
machinery.

• Warn female patient to avoid pregnancy and to
report a pregnancy that occurs during therapy

160

LOSARTAN POTASSIUM 50 MG AND
HYDROCHLOROTHIAZIDE 12.5 MG

TABLET

CATEGORY DESCRIPTION
PREGNANCY
LACTATION D

SPECIAL COUNSELING No Human Data—Probably Compatible, but an alternate
POINT drug may be preferred, especially while nursing a
newborn or preterm infant

• protect skin from the sun and to undergo regular
skin cancer screening due to potential for non-
melanoma skin cancer

• maintain adequate hydration, especially with
excessive perspiration, diarrhea, or vomiting

161

MAGNESIUM SULPHATE 50% INJECTION

CATEGORY DESCRIPTION
PREGNANCY D
LACTATION
SPECIAL COUNSELING Compatible
• Inj site irritation & pain.
POINT • May cause hypotension, hyporeflexia, CNS

depression

162

MAGNESIUM TRISILICATE MIXTURE

CATEGORY DESCRIPTION
PREGNANCY
Potential risk for humans fetal is unknown.
LACTATION Should only be used on the advice of a doctor
SPECIAL COUNSELING POINT
Limited human data – probably compatible

Should be taken on an empty stomach.

163

MAGNESIUM TRISILICATE TABLET

CATEGORY DESCRIPTION
PREGNANCY
Potential risk for humans fetal is unknown.
LACTATION Should only be used on the advice of a doctor
SPECIAL COUNSELING POINT
Limited human data – probably compatible

Should be taken on an empty stomach.

164

MEASLES, MUMPS AND RUBELLA (MMR)
VACCINE INJECTION (DOUBLE DOSE)

CATEGORY DESCRIPTION

PREGNANCY C

LACTATION Compatible

SPECIAL COUNSELING • Report fever or signs/symptoms of
POINT thrombocytopenia or SJS (flu-like symptoms,
spreading red rash or skin/mucous membrane

blistering)
• Female patients of childbearing age should use
reliable contraception to avoid pregnancy for at
least 3 months post-vaccination

165

MECLOZINE HCL 25 MG AND
PYRIDOXINE 50 MG TABLET

CATEGORY DESCRIPTION
PREGNANCY
LACTATION Meclozine HCL: B
SPECIAL COUNSELING Pyridoxine: A

POINT Not recommended for unless the expected benefits
outweigh any potential risk.

May impair ability to drive or operate machinery

166

MECOBALAMIN 500 MCG TABLET

CATEGORY DESCRIPTION
PREGNANCY B
LACTATION
SPECIAL COUNSELING Compatible
• Reduced absorption with alcohol intake
POINT • Gastrointestinal disorders: Nausea, vomiting,

diarrhoea, abdominal pain.

167

MEDROXYPROGESTERONE ACETATE
5 MG TABLET

CATEGORY DESCRIPTION
PREGNANCY X
LACTATION
SPECIAL COUNSELING Compatible
May be taken with or without food. Incidence of
POINT minor indigestion may increase as dose increases.

Take with meals if necessary.

168

MEDROXYPROGESTERONE ACETATE
50 MG/ML INJECTION

CATEGORY DESCRIPTION
PREGNANCY
LACTATION X
SPECIAL COUNSELING
Compatible
POINT
• Side effects include dysfunctional uterine
bleeding, headache, increased weight,
amenorrhea

• Report mood changes or worsening depression
• Injections site reaction

169

MEFENAMIC ACID 250 MG CAPSULE

CATEGORY DESCRIPTION

PREGNANCY C ;D(in 3rd trimester or near delivery)

LACTATION Limited Human Data—Probably Compatible (other
agents may be preferred, especially while nursing a
SPECIAL COUNSELING
POINT newborn or preterm infant

• This drug may cause dizziness, drowsiness, and visual
disturbances, if affected, do not drive or operate
machinery.

• Take with food or milk to minimize gastric irritation

170

MENINGOCOCCAL A, C, Y, W 135
VACCINE INJECTION

CATEGORY DESCRIPTION
PREGNANCY
No human data - should be given to a pregnant
LACTATION woman only if clearly needed
SPECIAL COUNSELING
Compatible
POINT
• May cause injection site pain or tenderness,
irritability, diarrhea, drowsiness, loss of
appetite, headache, and fatigue

• Immediately report symptoms of allergic
reaction or Guillain-Barre syndrome (eg muscle
weakness, numbness, tingling)

171

METFORMIN HCL 500 MG EXTENDED
RELEASE TABLET

CATEGORY DESCRIPTION

PREGNANCY B

LACTATION Compatible

SPECIAL COUNSELING • Should be taken with food.
POINT • Side effects include nausea, vomiting, diarrhoea,
abdominal pain, flatulence, heartburn/dyspepsia,
abdominal distention, abnormal stools,

constipation.

172

METFORMIN HCL 500 MG EXTENDED
RELEASE TABLET

CATEGORY DESCRIPTION

PREGNANCY B

LACTATION Compatible

SPECIAL COUNSELING • Should be taken with food.
POINT • Side effects include nausea, vomiting, diarrhoea,
abdominal pain, flatulence, heartburn/dyspepsia,
abdominal distention, abnormal stools,

constipation.

173

METFORMIN HCL 500 MG TABLET

CATEGORY DESCRIPTION

PREGNANCY B

LACTATION Compatible

SPECIAL COUNSELING • Should be taken with food.
POINT • Side effects include nausea, vomiting, diarrhoea,
abdominal pain, flatulence, heartburn/dyspepsia,
abdominal distention, abnormal stools,

constipation.

174

METHADONE 5MG/ML SYRUP

CATEGORY DESCRIPTION

PREGNANCY D - Human data suggest risk

LACTATION Limited human data – probably compatible

SPECIAL • Avoid activities requiring mental alertness or
COUNSELING POINT coordination until drug effect are realized
• Report symptoms of severe constipation
• Side effects include nausea, vomiting, abdominal pain,

anorexia, miosis, urinary retention

175

METHYL SALICYLATE 25% OINTMENT

CATEGORY DESCRIPTION
PREGNANCY
LACTATION C
SPECIAL COUNSELING
Use with precaution
POINT
• Do not apply to wounds, damaged skin or over
large areas of the body; bandage.

• Reduce dosage or frequency if irritation occurs.
Excessive application may increase chances of
bleeding with warfarin

176

METHYLDOPA 250 MG TABLET

CATEGORY DESCRIPTION

PREGNANCY B

LACTATION Limited Human Data—Probably Compatible

SPECIAL • May impair ability to drive or operate machinery.

COUNSELING POINT • Avoid activities requiring mental alertness or
coordination until drug effect are realized as drug may

cause sedation or dizziness

• May cause constipation, diarrhea, nausea, vomiting,
sore tongue, black discoloration of tongue, nasal

congestion, fever

177

METOCLOPRAMIDE HCL 10 MG TABLET

CATEGORY DESCRIPTION

PREGNANCY B

LACTATION Compatible

SPECIAL COUNSELING • This drug may cause drowsiness, dizziness, involuntary
POINT movements, if affected, do not drive or operate
machinery

• Administer drug 30 minutes before meal and at bedtime
• Report immediately symptoms of tardive dyskinesia

and/or extrapyramidal reactions

178

METOCLOPRAMIDE HCL 5 MG/ML
INJECTION

CATEGORY DESCRIPTION

PREGNANCY B

LACTATION Compatible

SPECIAL COUNSELING • This drug may cause drowsiness, dizziness, involuntary
POINT movements, if affected, do not drive or operate
machinery

• This drug may cause drowsiness, dizziness, involuntary
movements, if affected, do not drive or operate
machinery

179

METOPROLOL TARTRATE 100 MG
TABLET

CATEGORY DESCRIPTION
PREGNANCY
LACTATION C
SPECIAL COUNSELING
Limited Human Data—Potential Toxicity
POINT
• This drug may cause dizziness, if affected, do not
drive or operate machinery

• May cause diarrhea, depression, or fatigue
• Take a missed dose as soon as possible, but if next

dose is in less than 4h, skip the dose

180

METRONIDAZOLE 200 MG TABLET

CATEGORY DESCRIPTION

PREGNANCY B

LACTATION Hold Breastfeeding (Single Dose) Limited. Human
SPECIAL COUNSELING POINT Data—Potential Toxicity (Divided Dose)

• This drug may cause drowsiness, if affected do
not drive or operate machinery.

• Side effects may include seizures, nausea,
diarrhea, headache, dizziness, metallic taste,
rash, pruritus

181

MICONAZOLE 2% CREAM

CATEGORY DESCRIPTION
PREGNANCY C
LACTATION
SPECIAL COUNSELING Compatible
Avoid contact with eyes. Not to be used in children
POINT <2 year.

182

MONTELUKAST SODIUM 10 MG TABLET

CATEGORY DESCRIPTION

PREGNANCY B

LACTATION No human data- Probably compatible

SPECIAL COUNSELING • Report behavioural changes (e.g. agitation,
POINT anxiety, depression, dream abnormalities,
obsessive-compulsive disorder).

• Patient with asthma to take once daily in the
evening

• Patient taking drug to prevent exercise-induced
bronchoconstriction, to take drug at least 2
hours before exercise

183

MORPHINE SULPHATE 10 MG/ML
INJECTION

CATEGORY DESCRIPTION
PREGNANCY
C/D if prolonged use or high dose at term. Pregnant
LACTATION patients should only be given morphine when the
SPECIAL COUNSELING benefits clearly outweigh potential risks to the foetus

POINT Limited human data – potential toxicity

• This drug may cause CNS depression, if affected, do
not drive or operate machinery

• Side effects may include dizziness, anxiety,
confusion, nausea, vomiting, headache,
somnolence

184

MULTIVITAMIN SYRUP

CATEGORY DESCRIPTION
PREGNANCY Unassigned - compatible
LACTATION
SPECIAL COUNSELING Compatible
May be taken with or without food: May be taken
POINT
w/ meals for better absorption.

185

NALOXONE HCL 0.4 MG/ML INJECTION

CATEGORY DESCRIPTION
PREGNANCY C
LACTATION
No human data- Probably compatible
SPECIAL
COUNSELING POINT Side effects may include dizziness, injection site
erythema, dyspnea, pulmonary edema, cardiac arrest,

mental depression, apathy, inability to concentrate,
sleepiness, irritability, anorexia, nausea, and vomiting

186