Prosiding International Conference on Latest Trends and Innovations in Pharmaceutical and Biosciences

International Helpline No: +91-90791-34716 | oia.cpur.in | [email protected] Priya Lakhotiya MBA | Class 2021 ` 15 Lakhs Kiran Bablani BCA | Class 2018 7 Figures Salary Aryan Mathuria BCA | Class 2018 ` 66 Lakhs Naman Nandwana MBA | Class 2020 ` 10 Lakhs Vishnu Nair LL.B | Class of 2020 ` 15 Lakhs Teleperformance Transforming Passion into Excellence Quick Facts 2600+ Placements So Far 350+ Company Visited 905 National & Int'l Journal 26 Patent Published 352 International Students 572 National & Int'l Conference 900 Research Publication CPU offers the best of Academics, Exposure, Student life and Placements How to Apply: Online - www.cpur.in or In Person - Visit City Office at Road No.1, IPIA, Kota between 10:00 am to 07:00 pm Our Recognitions, Approvals and Knowledge Partner xq:xqZ:reks /kke NCTE UGC ASSOCIATION OF SELF-FINACING UNIVERSITIES OF RAJASTHAN A.S.F.U.R. BAR COUNCIL OF INDIA BAR COUNCIL BCI IOE AIU IIT Bombay PCI The Association of Commonwealth Universities ACU, London NPTEL Engineering & Technology I Computer Applications I Commerce & Management Health & Allied Science I Legal Studies & Governance I Pharmacy I Physiotherapy I Agriculture Basic & Applied Science I Nursing I Arts & Humanities I Education I Library & Information Science Admission Open in Various UG & PG Courses Campus: Alaniya, Kota - 325 003 (Raj.) City Campus: CP Tower, Road No.1, IPIA, Kota - 324005 (Raj.) Ph: 080-47250033 | website: www.cpur.in | email: [email protected] INTERNATIONAL CONFERENCE on Latest Trends and Innovations in Pharmaceutical and Biosciences” (ICLTIPB - 2023) Supported by International Journal of Pharmaceutical Sciences and Research (IJPSR) Organized by: Career Point School of Pharmacy, CPU, Kota th 18 March 2023 (Saturday) 080-47250033 www.cpur.in SOUVENIR

01 Souvenir Souvenir 02 International Conference 2023 based on the theme “Latest Trends and Innovations in Pharmaceutical and Biosciences” is conducted by Career Point School of Pharmacy, Career Point University, Kota. The conference spanning one day 18th March 2023, includes scientific symposiums by renowned international speakers which gives us an insight into the latest Emerging trends and Arificial Intelligence in Pharmaceutical, Biomedical Science and Technology. More delegates are expected to participate from all over globe. The unique event explores the significance of new trends, ideas, research experience, foster collaborations across industry, academia and evaluate emerging pharmaceutical technologies across the globe. This International Conference is aimed to provide a unique platform for professionals, researchers, academicians, industry delegates and allied fields of Pharmaceuticals and to interact / share their experiences and knowledge on Pharmaceutical and Biosciences. The technical sessions will consist of keynote talks on Quality Risk Management and advancement in pharmaceutical field followed by poster presentation with various awards for meritorious presentations. About the Conference S O U V E N I R

03 Souvenir Souvenir 04 Programme Schedule International Conference on Latest Trends and Innovations in Pharmaceutical and Biosciences th (18 March 2023) Inauguration Session 1 Introduction to the theme of Conference Student Anchors 2 Sarasvati Vandana Dance Perfomance 3 Welcome speech by Dean Sir Dr.M.K. Gupta 4 Speech of Vice Chancellor Sir Honourable Prof.Dr. T.R Sharma 5 Award Ceremony Faculty Anchors 6 Speech of Chancellor Sir Honourable Er. Pramod Maheswari 7 Award Ceremony Faculty Anchors 8 Introduction of Chief Guest Student Anchors 9 Speech of Chief guest Prof. (Dr) G.D. Gupta 10 Speech of Guest of Honour Dr. Kalandar Ameer 11 Speech of Guest of Honour Mr. Ajay Pathak 12 Speech of Guest of Honour Dr. Shashi Alok 13 Vote of thanks by Registrar Mr. Kamal Arora Technical Session I (1:00 pm – 4:00 pm) 1 Diversity of Pathogens and Diseases associated with Dr Poonam Burman selected Field Crops at Bathinda Region of Punjab, India 2 Hepatoprotective Potential of Tinospora cordifolia and Manvendra Singh Eclipta alba Extract Compared with Market Formulation 3 A review of the optimization and characterization of Phytosome Pranjal Sachan 4 Design, Synthesis and Biological Activity of New Substituted Pyrimidine Anamika Singh Derivative as ?-Glucosidase Inhibitory Activity 5 A Combination Therapy for Anti-Microbial Resistance in skin Infection - Kumar Vishwakarma Pradeep Eradication by Nano ointment 6 Sex dimorphism in circulating leptin concentrations in relation to BMI Dr. Loushambam Samananda Singh 7 Use of Biotechnological approaches to enhance properties Nivedita Gupta of vegetable crops 8 Field Evaluation of the Potential of Cow Based Products in the Mgmt. of Mustapha Abubakar Whitefly (Bemicia tabaci G.) Population on Eggplant(Solanum Melongena L.) 9 Anti-inflammatory nature of Nyctanthes arbor tristis Ankit Shukla 10 Cardioprotective Effects of Lavandula stoechas in Isoprenaline induced Mohd Aftab Siddiqui Myocardial Necrosis in Rats 11 Tumor-Targeted Drug Delivery System Anjali Soni 12 Future prospects for Cancer Immunotherapy Priyanka Yadav 13 Microspheres as a novel Drug Delivery System Ankit Kulpare 14 Gold Nanoparticles in Cancer: -Treatment, Diagnosis and Detection Amreen Qureshi 15 Natural Superdisintegrants- Novel concept in oral drug Delivery Dharmendra Solanki 16 Nanosponges- A Review Muskan Jain 17 Moringa leaves health drink for Malnutrition in children Naincy Jain 18 Detection, treatment and hormonaltherapy: -for infertility due to PCOS Ritu Jaiswal 19 Formulation and characterization of matrix dispersion type Prachesh Pandey transdermal patch of Metoprolol Succinate 20 Transdermal Effect of Tamoxifen Citrate on induced Breast Cancer Chandra Shekhar Sharma 21 Liposomal drug delivery system: Newer approaches Beena Rathore 22 A Comprehensive Review on Peptic Ulcer Rishabh Gaur 23 Pathophysiological Status, Molecular pathways and Treatment Kunal Suryavanshi Updates on Huntington's Disease 24 A Study of Plants using Medicinal Properties to treat Malaria: Harsh Jain A Clinical Review Technical Session II (1:00 pm - 4:00 pm) 25 Formulation and evaluation of Tea Tree Oil Gel Karan Agrawal 26 Computer Aided Screening and In-vitro Anticancer Activity of Bioflavonoid Shailendra S. Suryawanshi Fractions of Muntingia Calabura against Colo 205 Cancer Cell Lines 27 Comparative efficacy of Curcumin, Curcuma longa (Turmeric) and Alveena Ganai Nitazoxanide against Cryptosporidium Parvum infection in mice 28 Biodiversity & conservation of management Vikram Pandey 29 A review on Food Technology Ashi Patel 30 A Survey On the use of Medicinal Plants in the Treatment of Anamika Rathore Myocardial Infarction Disease 31 Cell membrane-derived vesicles for therapeutic drug delivery Innocent Sutnga 32 Derivatization of flavanoid and evalution of anti-inflammatory activity on Kripa Shankar Singh experimental animals 33 Development and evaluation of voriconazole loaded nanostructured lipid Akanksha Patel carriers for topical mycoses 34 Chemistry of traditional medicinal products used as a crucial source for Akash Sharma the discovery of potential Anti-Tubercular Drugs 35 Molecular docking of phytoconstituents of Abelmoschus esculents for Varsha Yadav antidiabetic activity 36 Patents in Pharmaceutical Research and Development Sheela Suthar 37 Importance of regulatory affairs and intellectual property rights (ipr) in Mohammad Azhar Pharmaceutical Industry 38 Design and Evaluation of Losartan Potassium Sustained And Bimal Debbarma Hydrochlorothiazide Immediate Release Drug Formulation 39 Development of highly predictive QSAR models by using kNN and MLR Ruqaiya Jamal methods for anti-inflammatory activity of thiazole derivatives 40 Formulation and Evaluation of Transdermal Patch of Acetyl Sudhanshu Mishra Keto Boswellic Acid for Treatment of Arthritis 41 Design and optimization of fast dissolving solid oral formulations of Pravin K. Bhoyar etodolac using solvent free technology by 32 factorial designs 42 Pharmacological Assessment of Herbal Suspension for Anish Kumar Anti Parkinson activity in rat 43 Formulation and evaluation of solid lipid nanoparticles of baclofen for Sushant Chaudhary improvement of muscle relaxant action 44 Drug Delivery from the Hydrogels Gaurav Tailor 45 Review Article on Nicotine Originated Jitendra Kr. Singh (Active and Passive Diseases at 21 Century) S.No. Event Participant S.No. Event Participant

05 Souvenir Souvenir 06 46 Computer Aided Investigation of Physicochemical Properties and Drug Likeness Profile of Selected Vitamins and Related Analogues Drug Patil Adarsh Arun Likeness Profile of Selected Vitamins and Related Analogues 47 Computational Study of Phytochemistry and Drug Likeness Properties of Ronak Dsouza Selected Plant Compounds from Aloe Vera 48 A Case Study on Citrus Orchards Pests and Their Management Bhujabal Singh Parihar Session III (1:00 pm - 4:00 pm) 49 Formulation, evaluation, and anti-bacterial activity of Ceftazidime and Rohit Kumar Singh Clove oil-loaded Solid lipid nanoparticle 50 Preparation of Nanoemulsion loaded with antiretroviral drug for the Shivani Tyagi management of NeuroAIDS 51 Formulation and evaluation of nano-cocrystal of an anti-hyperlipidemic Anusha Jain drug for the management of hyperlipidemia. 52 LC-MS Determination of Bioactive Constituents of Kalyani U. Chande Glycyrrhiza glabra Root Extract 53 Development and Evaluation of Phage therapy against MRSA Ankita Alice Singh (biofilm forming) in experimental animal model 54 In-Silico Prediction of Drug Likeness Properties of Selected Prathamesh Magadum Phytochemicals of Azadiractha Indica 55 Investigation of Physicochemical Properties of Selected Shreyansh Phytoconstituents of Arjuna by Computer Aided Drug Design Tools 56 Application Of Herbal Technology In Memory Enhancement To Control Sunita Roy Dementia Caused By Alzheimer Disease 57 Formulation and evaluation of polyherbal extract face serum Virashri Dhumal 58 Ligand Based Pharmacophore Modelling, Virtual Screening and Molecular Pragya Sharma Docking to Identify Novel SCD Inhibitors for the treatment of Metabolic Syndrome 59 Impact of endophytic fungi isolated from ajuga bracteosa wall. Ex benth. Kiran Sharma On anti-oxidant potential of plant perilla frutescens (l.) Britton 60 Preliminary Phytochemical Screening & HPTLC Finger printing analysis of Vishal S. Adak Seeds Extracts of Vernonia anthelmintica (L) & Trachyspermum ammi (L) 61 Antioxidant potential of urtica dioica leaves growing wild in different Diksha Sharma forest regions of himachal Pradesh 62 Analysis of anti-inflammatory activity of jasminum officinale l. And Mehak erigeron annuus (l.) Pers. For the treatment of diabetes mellitus in himachal pradesh of western Himalayas 63 Evaluation of antioxidants of cotoneaster microphyllus wall. Ex lindl. Ritika Dadhwala Leaves and fruits growing in distt. Shimla of himachal pradesh. 64 Review on adulterants in the ayurvedic formulation Madan Lal 65 A review on artificial intelligence in new drug devopment: present status Bidyut Bikash Laskar and future prospects 66 Current trends in pharmaceutical analysis to promote contemporary drug Achangliu Pamai discovery by in- silico profiling of drugs and related substances. 67 Formulation and evaluation of topical hydrogel of luliconazole loaded beta Shubhi Yadav cyclodextrin nanosponges 68 Thymus vulgaris: a phytopharmological review Nitin Shukla 69 Innovation Technology for Efficiency in Healthcare System Ms.N.Indumathi 70 Innovation Technology of Artificial Intelligence for Improving Efficiency in Ms.N.Indumathi Healthcare System 71 Systematic Comparative Analysis of Pharmacognostic profile of some Navjot Kaur species of Genus Euphorbia. 72 Production of natural disinfecting agents from garbage enzyme and Liza Boro comparison of their efficacy with commercially available products 73 Comparative qualitative analysis of yasad bhasma with classical and S. A. Chavhan modern parameters 74 Synthesis, biological evaluation of new quinoline derivatives as a potent Arshi Atiya anti-inflammatory activity 75 Formulation and evaluation of baclofen loaded liposomal hydrogel Sanjay Kumar Patel Session IV (1:00 pm - 4:00 pm) 76 In silico study on 1,3,4 thiadiazole derivatives tethered with isoniazid on Brundha S N her 2 for anti breast cancer activity 77 Nano emulsion based carotenoids extraction Swanand Kulkarni 78 To estimate eugenol in pure and Myristica fragrans seed extract, a forced Nikita Panwar degradation study using the HPTLC method was conducted. 79 Therapeutic potential of Quercetin loaded topical nano-formulations: Zarnain Fatima A systematic review 80 Formulation and Evaluation Etizolam Loaded Polymeric Nanoparticles in Awate Pravin treatment of Anxiety Disorders: Research 81 3-D PRINTING: Innovative aspects in pharmaceutical industry Neha Rao 82 Preparation and in-vitro antidiabetic evaluation of raphanus sativus Pavan Kumar Yadav extract-loaded nanoparticles 83 Potential Use of Indoor Plants to Ameliorate Indoor Air Quality: An Overview Snehal S. Manekar 84 Current Trends and Future Strategies in the Diagnosis & Management of Azaz Ahmad Uterine Fibroids 85 Pharmacological study on antidiabetic and antioxidant activity of Sachin Kumar Agrahari methanolic extract of leaves of achyranthes aspera and phaseolus vulgaris linn. 86 A tool for evaluating the economic impact of drug therapies: Akanksha Pandey pharmacoeconomics 87 Robotic technology in paediatric neurorehabilitation Harshita Mittal 88 Analysis of acetylenehexacarbonyldicobalt complexes as a potential Rahul Arun Jagtap anti-cancer agent through IR, NMR and GC-MS techniques 89 Estimation of Anidulafungin and related compounds in intravenous dosage Ruchi Verma form by RP-HPLC method 90 Nanoemulsion for the management of neuroaids by ARV therapy: Kunal Verma Development and evaluation. 91 Design, development and characterization of kalanchoe gastonis bonnieri E. Selvakumari (crassulaceae) including dna authentication studies 92 Pharmacological evaluation of leafs extract of ficus auriculatalour Deepak Chandra Joshi for anti ulcer activity 93 Pd-catalysed [3+2]-Cycloaddition towards the generation of Manmohan Sharma bioactivebis-heterocycles/Identification of COX-2 inhibitors via insilicoanalysis 94 Phytochemitry, medicinal uses along with its biological activities of Prateek Porwal amoora rohituka (meliaceae) leaves 95 A biological production of copper, iron, and nickel nanoparticles and its Surinder Kumar potential uses and its potential uses 96 Neuroprotective effect of flavonoid in 3 NPA induced 97experimental Afsha Khan animal model of HD phenotype via 98regulating Nrf2/ Nf-kb signaling pathway.

07 Souvenir Souvenir 08 97 Beneficial electrolytes present in the juice of cocos nucifera Ankita Agarwal 98 Design of Novel 2-mercaptobenzimidazole Derivatives for the treatment Nayana R. Jawale of Prostate Cancer: An In-silico Approach 99 Identification of Novel 2-mercaptobenzimidazole Derivatives for the Nayana R. Jawale treatment of Breast Cancer: A Computational Approach 100 Scientific Update on Alzheimer's Disease Khushal Garg Session V (1:00 pm - 4:00 pm) 101 Phytochemical screening and in vitro and in vivo Antioxidant Potential of Sushila Gupta Jasminum sambac flowers 102 Scientific Update on Myocardial infarction Yatin Kumar 103 Pharmacognostic and phytochemical evaluation of Rumex acetosa Anuradha 104 Herbal Gel shampoo enriched with bitter Melon and Vitamin E Akriti Yadav 105 Stability- indicating method development & validation of glycyrrhizin using Waibiangki Lyngdoh rp-hplc-dad: quantification of glycyrrhizin in glycyrrhiza glabra extract 106 Formulation and evaluation of phytosome-loaded n-hexane extract of Jugal Sutradhar flowering buds of Mesua ferrea Linn. Gel 107 Phytochemistry, Medical uses along with it's Biological Activity of Flower of Vinay Kumar Siroliya Nymphaea alba (Nymphaeaceae) 108 A General Case Study: Healthcare Data Visualization on Tuberculosis in Bharat Lal M.P. (District-Satna) 109 Review on Preventing Undue Exertion Utilizing Physiogenix Cut Harshika Gupta Ingedgeattechnology for Sports Concussions 110 Thymoquinone Estimation in Seed Powder Extracts of Nigella sativa by Mohamad Taleuzzaman HPTLC Analytical Technique Nabila 111 The Role of Clove Oil in the Treatment of Topical Fungal Infection: A Review Priya Chourasia 112 Therapeutic Potential of Hemp Seed Oil: A Review Ashish Miglani 113 Recent Approaches for Cancer Treatment through Gene Therapy Dhruva Garg 114 BGT222 Loaded Solid Lipid Nanoformulation Suppresses the Migration Satyam Sharma and Invasion in Human Colon Cancer CACO-2 Cells Via Modification of Raptor, HDAC, DNMT-1, Oxidative and Apoptotic Cascades 115 Formulation and Evaluation of Poly Herbal Syrup for Treatment of Dengue Raunak Mishra 116 Formulation and Characterization of Herbal Extract Containing Lip Balm Akanksha Mishra for the Treatment of Lip Pigmentation 117 Rapid Dissolving Film for Novel Drug Delivery Systems: Ajeet Kumar A New Route for Quick Migraine Relief 118 Formulation Development and Evaulation of Atorvastatin Tablet by using Hanumant Sharma Finger Millet (Eleusine corocana) Starch as Natural Disintegrant 119 Pharmacological Screening of Sanseveria cylindrica in Abhishek Marwari Management of Obesity 120 Pharmacological Effects of Extract of Carica papaya Leaves Chhavi Verma 121 Formulation Development & Evaluation of Dermatological Polyherbal Gel Abhay Pratap Singh for Acne Treatment 122 Interaction of Antihypertensive Drug with Garlic in Rat Anamika Gautam 123 A Review on the Methods of Preparation of Nanoparticles and Applications Neha Singh 124 Evaluation of Chenopodium Album Leaves Extracts for Nootropic Lalit Kumar Activity Potential in Wistar Rats 125 Memory Enhancing Activity of Dracaena trifasciata Leaves Extracts on Sarita Rani Scopolamine Induced Amnesia in Wistar Rats Session VI (1:00 pm - 4:00 pm) 126 Evaluation of the Antihypertensive Effect of Rumex Nepalensis Leaves Ajay Kumar Extracts on Ethanol-Induced Hypertension in Wisar Rats 127 Hepatoprotective Activity of the Commelina benghalensis Leaves in Anushka Ethanol-Induced Hepatotoxicity in Rats 128 Evaluation of Antiulcer Activity of Leaves of Rubus ellipticus in Anjali Experimental Animal 129 Preclinical Screening of Chenopodium album Leaves Extracts for Ayushi Bhatnagar Anti-Obesity Activity 130 Determination and Evaluation of Anthelmintic Activity of the Leaf Ashish Kumar Extract of Anthocephalus cadamba MIQ 131 Formulation Development and Evaluation of Tablet Containing Dipanshu Kumar Rosuvastatin with Neutraceutical Potential 132 Development and Evaluation of the Inclusion Complex of Gliclazide with Mukul Kumar Rana Hydroxy-Propylbeta- Cyclodextrin 133 Screening of Calotropis procera Roots Extracts for Antidepressant and Preeti Sisodia Antianxiety Potential in Swiss Albino Mice 134 Solid Lipid Nanoparticle Design, Development and Evaluation for Improving Neeraj Chauhan the Bioavailability of Certain Anti-Hypertensive Medications 135 Antidiabetic Activity and Phytochemical Screening of Plumbago zeylanica Nisha Leaves Extracts in Streptozotocin-Induced Diabetic Rats 136 Development and Optimization of Self- Nano Emulsifying Drug Delivery Rajat Chauhan System of Ibrutinib 137 Preparation and Standardization of Polyherbal Powder for the Ankita Patel Management of Hypercholestrolemia Disease 138 Formulation and Standardization of Herbal Extract Containing Rahul Kumar Pandey Multi-Purpose Cream 139 Biodiversity Conservation and Environmental Perspectives: Jai Prakash Sharma A Geographical Analysis 140 Demand of New Policies on Pharmaceutical Industry Sangeeta Mathur 141 Social Policies in Pharmacy Reeta Saxena 142 Phytochemical Analysis and Antibacterial Properties of Butea monosperma Sachin Kumar 143 Synthesis And Anti-Inflammatory Activity of 2- Amino Benzothiazole Vijay Tambe 144 HIV Activities of 2-Amino Benzothiazole Uday Suryawanshi 145 Anxiolytic Activity of Sanjeevani bryopteris using Experimental Aayushi Tyagi Animal Model 146 Urmila'S Role in Shaping the Destiny of Ayodhya: an Analysis of Her Neeta Audichya Character in the Context of Politics and Power Dynamics in Ancient India 147 Legal Regulations of Traditional Medicines in India Anjali Dixit 148 Emulgel Formulation- An Effective Approach for Treatment of Skin Diseases Anjali Jain 149 Thioglycolic Acid as Stabilizer Rakhi Methi 150 Nanoformulations Approach for Improved Stability and Efficacy of Deepika Aggarwal Herbal Drugs Offline Session I (1:00 pm - 4:00 pm) 151 Artificial Intelligence in Pharmacy and Bioscience Munajir Rajja 152 A Review: Therapeutic Potential of Flavonoid and Evaluation of Devangi Solanki Herbal Gel for Wound Healing 153 1,3,4-Oxadiazole Derivatives As Antimicrobial Agent Via DNA Gyrase Inhibiton Pankaj Gupta

09 Souvenir Souvenir 10 154 Comparative Study of Physico-Chemical and Phytochemical Monika Pandey Screening of Some Selected Antidiabetic Medicinal Plant 155 Quinoline Hydrazide/Hydrazone Derivatives: Antibacterial Potential, Sangeeta Verma Structure Activity Relationship and Mechanism of Action 156 Efficient Method for Determination of Organic Impurities in Alogliptin and Pradeep Swarnkar Metformin Dosage form by Using RP-HPLC 157 Alternatives to Animal Research Somya Gupta 158 Have You Know about Off Label use of Drug? Ved Prakash Jadaun 159 An Overview on Nanostructured Lipid Carrier Based Drug Delivery System Preeti Choudhary 160 Artificial Intelligence in Pharmacy and Bioscience Rita Yadav 161 Pharmacognostic and Phytochemical Studies of Leaves of Syzgium cumini Varsha Yadav 162 Anti-Inflammatory Activity Determination of A Polyherbal Formulation Garvita Chaudhary Joshi Containing Tinosporia cordifolia, Moringa oleifera and Allium sativum 163 Microneedles: Recent Development in Vaccine Through Transdermal Tulsi Tak Drug Delivery System 164 Research of Oral Pill Discovery for Insulin Drug Delivery Jyoti Nagar 165 A Comparative Study on the Effect of Adsorption Parameters of Ni (Ii) in Alkaline Soil Deepak Hada 166 Role of Phenolic Compounds in Modulating Signalling Pathways to Swati Shukla Combat Skin Ageing 167 Protective Effects of Methanolic Extract of Acalypha Hispida Leaf on A V Shrirao Streptozotocin Induced Diabetic Peripheral Neuropathy in Rats 168 Soil and Water Conservation for Sustainable Agriculture Manisha Sharma 169 Improvement of Solubility and Oral Bioavailability of Cefuroxime S. T. Landge Axetil by Hot Melt Extrusion Technique 170 Tirzepatide New Era of Dual Targated Treatment for Diabetes and Obesity Archi Gupta 171 The Role and Future Prospect of AI-Based Neural Network Models in the Mridula Chauhan Diagnosis of Diabetes Related Peripheral Neuropathy 172 To Observe and Isolation and Treatment of Mycobactrium Tuberculosis Gaurav Kamewal 173 An Overview of Application of Nutraceutical In Human Disease Lucky Ali 174 Health Benefits of Daucus carota (Carrot): A Review Amrik Dey 175 Neuroprotective Effect of Flavonoid in 3 NPA Induced Experimental Animal Afsha Khan Model of HD Phenotype via Regulating NRF2/ NF-KB Signaling Pathway Offline Session II (1:00 pm - 4:00 pm) 176 Artificial Intelligence in Pharmacy Devansh Vijayvargiya 177 Statistical Analysis of Sound Pollution Pre and Post Covid Period in Pooja Bhatnagar Mansarover Area Jaipur (Rajasthan) 178 SGs Of Kelkhoyra Shiv Temple, Jhalawar - Ideal Centre for Prakash Yadav Biodiversity Conservation 179 To Observe Depression, Mental Illness, Therapy and Treatment Shyam Baran Singh 180 Melt Granulation - A Promising Approach for Improving the T. Naga Aparna Bioavailability of Poorly Soluble Drug - Sorafenib 181 Syndromes Associated with Antibiotics Lokesh Singh 182 Phytochemical Screening, In Vitro Anti-Oxidant Activityand In Rakesh Kumar Niranjan Vitro Anti-Diabetic Activity of Leaves Of Paeoniaemodi Extract 183 Formulation Development & Evaluation of Mucoadhesive Buccal Film of Shalini Betamethasone for Oral Ulcer Treatment 184 Drug Delivery System Akshat Sharma 185 Drug Discovery and Its Development Rahul Suman 186 Development and Evaluation of Emulgel of Celecoxib by using Natural Oil Arati Rajput 187 A Brief Assessment of Recent Improvements in Nonionic Surfactant-Based Deepak Kumar Gupta Nano-Vesicles (Proniosomes) for Improving Transdermal Drug Delivery 188 Impact of Health issues in the Pharmaceutical Field in Modern Times in Raj. Ashish Jorasia 189 Evaluation of Oroxylum indicum on Alloxan Induced Rats for Antidiabetic Activity Om Sugandhi 190 Financial Structure of the Pharmaceuticals Industry Ravi Ranjan 191 Formulation and Comparison Between Two Methods for Dipak V. Bhusari 5-Fluorouracil-Loaded Chitosan Microspheres 192 A Study on Challenges in Implementation of GST with Respect to Jyoti Peswani Restaurant Industry 193 Management of short-term capital in leather industries Fayeza Hakimuddin Sonkachwala 194 Structural Electronic and Optical Properties of SiO2 Materials Sakshi Shukla 195 In vitro antioxidant and antidiabetic activity of hydro-alcoholic extract of Anil Kumar Meena selected common agricultural weed plants 196 A Review Paper on "Consumer Behavior in Tourism: Concepts, Ashutosh Kumar Infuences and Opportunities" 197 Enrichment of Saponin content in the washes of roots of Abhishek Nagar Chlorophytum borivilianum 198 Isoniazid and Rifampicin induced hepatoprotective activity of roots and Harshita Jain leaves extract of Picrorhiza kurroa 199 Formulation and Characterization of Bauhinia racemosa extract loaded Nitin Nama nanoemulsion by box Behnken Design 200 Evaluation of Toxicological and Anti-anxiety effect of Gingerol Chetan Kumar Dubey 201 A Review on Esters and Fatty acids from Pleurospermum densiflorum Saurabh Chaturvedi 202 A Clinical Overview Of Insulin Pump Therapy For Management Of Diabetes Riya Yogi 203 Formulation and Evaluation of Resveratrol loaded Microparticles or Shabenoor Siddiqui Controlled Drug Delivery 204 Children's Drug Abuse: An Increasing Problem in India Mithlesh Malviya 205 Hindu Women'S Rights To Property: An Indian Approach After Independence Jay Prakash Srivastava 206 The Ethical Implication of The Ayurvedic Cosmetic Products - A Pestle Ankita Nawal Analysis Study Of The Indian Ayurvedic Cosmetic Sector With A Special Focus On Indian Youth 207 Nanoemulsion For The Management of Neuroaids By Arv Therapy: Kunal Verma Development and Evaluation 208 Formulation And Characterization of Gastroretentive Superporous Ankita Malviya Hydrogel Tablets of Labetalol Hydrochloride 209 In-Vitro Evaluation of an Anti-Fungal Nail Lacquer Containing Miconazole Nitrate Navneet Kumar Verma 210 Pharmacological Applications Of Moringa Oleifera (Medicinal Plant) Ankur Yadav 211 Pharmacological Activity of Fluoxetine And Fluoxetine Derivatives Shiwani Jaiswal 212 Pharmacological Importance of Flax Seed (Linum Usitatissimmum L.) Vikas Yadav 213 Pharmacological Screening of Chrozophora Tinctoria Leaves Extract Neha Srivastava As Antidiabetic Effect In Rat 214 Enhancement Of Natural Drug Aqueous Solubility By Using Various Method Neelam Yadav 215 A Comprehensive Study on the Impact of Performance Management Sandeep Kumar Systems on Pharmacy Staff Motivation and Job Satisfaction in Rajasthan 216 Assessing the Effectiveness of Pharmacists' Medication Therapy Aditi Gaur 217 Study of Medicinal Plants of Gagron Fort and Its Environs Divyendu Sen 218 Compulsory Licensing Of Patent In India: Balancing Intellectual Property Kunal Rohira Rights and Public Health Concerns

11 Souvenir Souvenir 12 219 Molecular Bottlebrush Prodrugs As Mono-And Triplex Combination Shumayel Hasan Therapies For Multiple Myeloma 220 Design and Characterisation of Tamoxifen Nanosponges for K. Kranthi Kumar Targeted Drug Delivery 221 Drug Discovery and its Development Rahul Suman 222 Food Technology Parth Gurjar 223 Artificial Intelligence in Physiotherapy Damini Pareta 224 Drug Delivery System Shagun Gupta 225 Research of Oral Pill Discovery for Insulin Drug Delivery Jyoti Nagar 226 A Review on Anti-Ulcer Activity from Pistia Stratiotes Ravi Gupta 227 A Review on Indian Medicinal Plants in Diabetes Mellitus Shubhanshu Singh 228 Hyphenated Techniques for Fingerprinting of Herbal Drugs Uttam Singh Baghel 229 Regulatory Aspects of Herbal Medicine Kapil Sharma 230 A Comparative Study of Statistical Analysis of Physio-Chemical Parameters Neha Kaithwas of Water of Dholawad Dam and Mahi Bajaj Sagar Dam on Mahi River 231 "Old Drugs - New Methods"- A Review On Antiviral Drug Repositioning Roma Sharma 232 The effect of Neochetina eichhorniae on the Growth of Eichhornia Arun jatav crassipes at Ayana pond, Kota, Rajasthan Hon'ble Mr. Pramod Maheshwari Chancellor, CP University, Kota Mr. OM Maheshwari Director, Career Point, Kota Chief Patron Hon'ble Prof. (Dr.) T.R. Sharma Vice Chancellor, CP University, Kota Patron Prof. (Dr.) Gurudatt Kakkar Pro Vice Chancellor, CP University, Kota

It gives me immense pleasure that Career Point School of Pharmacy in association with Interantional Journal of Pharmaceutical Sciences & Research is Organizing National Conference with the theme “Latest Trends and Innovations in Pharmaceutical and Biosciences” on 18th March 2023, under the flagship of Career Point University. Over the course of this conference, you will have the opportunity to participate in thoughtprovoking discussions, gain valuable insights from experts, and network with like-minded individuals from different countries and backgrounds. I would like to express my sincere gratitude to the organizers of this conference, who have put in countless hours of hard work and dedication to bring this event to fruition. I would also like to extend my appreciation to all the distinguished guests for taking the time to attend and contribute to this conference. I hope that this conference will serve as a catalyst for new ideas, collaborations, and discoveries that will drive progress in the field of pharmaceuticals and biosciences for years to come. Thank you, and I wish you all a successful and fruitful conference. Chancellor's Message Hon'ble Mr. Pramod Maheshwari Chancellor, CP University, Kota (Raj.) & Hamirpur (H.P.) 13 Souvenir Souvenir 14 It is with great pleasure that I welcome you to this International Conference on Latest Trends and Innovations in Pharmaceutical and Biosciences. As the Chairman of this conference, I am honored to have the opportunity to bring together experts from around the world to discuss the latest advancements in these rapidly evolving fields. The pharmaceutical and biosciences industries have been at the forefront of scientific progress, with new discoveries and breakthroughs happening every day. This conference is a platform for sharing knowledge, experiences, and ideas, as well as networking with likeminded individuals who are committed to advancing these fields. I would like to extend my heartfelt appreciation to the organizing committee for their tireless efforts in planning and executing this conference. Their hard work and dedication have made this event possible, and we owe them our deepest gratitude. I would also like to thank all the participants and guests for joining us and contributing to this important gathering. I wish you all a productive and engaging conference and look forward to fruitful discussions and exciting new discoveries that will drive the future of pharmaceuticals and biosciences. Thank you. Director's Message Hon'ble Mr. OM Maheshwari Director, Career Point, Kota

On behalf of the University, I extend a warm welcome to all of you to the International Conference on Latest Trends and Innovations in Pharmaceutical and Biosciences. As ViceChancellor, it is my honor to host this prestigious event that brings together leading experts, scholars, researchers, and professionals from around the world to share their latest research, insights, and innovations. I would like to express my sincere gratitude to the organizing committee for their tireless efforts in organizing this conference. Their dedication and hard work have ensured that this event is of the highest quality and standard. I would also like to thank all the participants and guests for their attendance and contributions to this event. I hope that this conference will not only be a fruitful and enriching experience for all the participants but also serve as a catalyst for further research, innovation, and collaborations that will positively impact the fields of pharmaceuticals and biosciences. Thank you, and I wish you all a successful and inspiring conference. VIce -Chancellor's Message 15 Souvenir Souvenir 16 It gives me great pleasure to welcome you all to this International Conference on Latest Trends and Innovations in Pharmaceutical and Biosciences. As Pro-Vice-Chancellor of this esteemed university, I am honored to host this conference and bring together the brightest minds from across the world to discuss the latest advancements in the field of pharmaceuticals and biosciences. I would like to express my appreciation to the organizing committee for their hard work and dedication in making this conference a reality. I would also like to thank all the participants and guests for joining us and contributing to this important event. I hope that this conference will be a fruitful and inspiring experience for all of you, and I look forward to witnessing the ideas, collaborations, and discoveries that will emerge from this event. Thank you, and I wish you all a successful and enriching conference. Pro-Vice-Chancellor's Message Prof.(Dr.) T. R. Sharma Vice-Chancellor, Career Point University, Kota Prof. (Dr.) Gurudatt Kakkar Pro-Vice-Chancellor

It is my pleasure to welcome you to the International Conference on Latest Trends and Innovations in Pharmaceutical and Biosciences on 18th March 2023. As the Convenor of this conference, it is my honor to bring together leading experts, researchers, and professionals from around the world to discuss the latest advancements and trends in these critical fields. Our distinguished speakers and participants from across the globe will share their latest research, insights, and innovations, engage in lively debates, and build new collaborations that will drive progress in pharmaceuticals and biosciences. I am confident that this conference will lead to new discoveries, inspire innovative solutions, and positively impact the future of these fields. I would like to express my sincere appreciation to the organizing committee for their tireless efforts in putting together this conference. Their hard work and dedication have ensured that this event is of the highest quality and standard. I would also like to thank all the participants and guests for their attendance and contributions to this event. I hope that this conference will be a productive and inspiring experience for all of you, and I look forward to witnessing the ideas, collaborations, and discoveries that will emerge from this event. Thank you, and I wish you all a successful and engaging conference. Convener's Message 17 Souvenir Souvenir 18 It is with great pleasure that I welcome you to the International Conference on Latest Trends and Innovations in Pharmaceutical and Biosciences. As the Registrar of this esteemed university, I am delighted to host this conference that brings together leading experts, scholars, researchers, and professionals from around the world to discuss the latest advancements and trends in pharmaceuticals and biosciences. I am confident that the distinguished speakers and participants from across the world will share their latest research, insights, and innovations, engage in lively discussions, and build new collaborations that will lead to new discoveries and innovative solutions in pharmaceuticals and biosciences. I hope that this conference will be an engaging and fruitful experience for all of you, and I look forward to witnessing the ideas, collaborations, and discoveries that will emerge from this event. Thank you, and I wish you all a successful and inspiring conference. Registrar's Message Mr. Kamal Arora Registrar, Career Point University, Kota. Prof (Dr.) M. K. Gupta Dean, Pharmacy, Career Point University, Kota

It is an honor to be here today as the chief guest for the International Conference on Latest Trends and Innovations in Pharmaceutical and Biosciences on 18th March 2023. I would like to begin by expressing my sincere appreciation to the organizing committee for putting together this remarkable conference, which brings together some of the brightest minds in the fields of pharmaceuticals and biosciences. I would like to take this opportunity to applaud the organizers and participants for their commitment to advancing the fields of pharmaceuticals and biosciences. Your work is critical to improving the health and well-being of people around the world, and I am honored to be a part of this conference. In conclusion, I wish you all a successful and productive conference. I hope that this event will inspire new ideas, lead to innovative solutions, and positively impact the future of pharmaceuticals and biosciences. Thank you. Chief Guest Message 19 Souvenir Souvenir 20 I am truly honored to be the Guest of Honour at this prestigious International Conference on Latest Trends and Innovations in Pharmaceutical and Biosciences, focusing on drug designing using bioinformatics. It is a remarkable opportunity to address such a distinguished gathering of experts in the field. Bioinformatics has revolutionized the process of drug designing, offering powerful computational tools and techniques that have significantly impacted the pharmaceutical industry. The integration of bioinformatics in drug discovery and development has not only accelerated the process but has also improved the success rates of identifying promising drug candidates. I have no doubt that this conference will serve as a catalyst for further advancements in drug designing using bioinformatics. It is my hope that the discussions, presentations, and interactions during this event will stimulate innovative ideas, forge new partnerships, and drive transformative progress in the field. Thank you all for your valuable contributions, and I wish you a rewarding and successful conference. Guest of Honour Message Prof. (Dr.) Yuvaraj Singh Director, B.N. College of Pharmacy, Udaipur, Rajasthan, India Prof. (Dr.) G.D. Gupta Director, ISF College of Pharmacy, Moga, Punjab, India.

I am deeply honored to be the Guest of Honour at this prestigious International Conference on Latest Trends and Innovations in Pharmaceutical and Biosciences, focusing on drug designing using bioinformatics. As a Drug Control Officer at Baran, Rajasthan, I have witnessed firsthand the importance of cutting-edge research and innovations in the field of pharmaceuticals. As a Drug Control Officer, I understand the importance of ensuring the safety, efficacy, and quality of pharmaceutical products. By leveraging the power of bioinformatics, we can enhance the process of drug discovery and development, leading to the creation of more effective and safer drugs. I have no doubt that the discussions and interactions during this conference will inspire new ideas, foster collaborations, and drive meaningful advancements in pharmaceuticals and biosciences. Thank you all for your valuable contributions, and I wish you a productive and enlightening conference. 21 Souvenir Souvenir 22 It is my great pleasure to address you today as the keynote speaker for the International Conference on Latest Trends and Innovations in Pharmaceutical and Biosciences on 18th March 2023. I am excited to share with you my insights and experiences in the field of drug designing using bioinformatics. The use of Computer added drug designing is increasing day by day in pharmaceutical sector with high rate of acceptance among the users. Bioinformatics has transformed drug designing by providing tools to predict the efficacy and toxicity of a drug candidate before it is synthesized and tested in vivo. The ability to predict the behavior of a drug candidate before it is tested can save time and reduce costs, as well as increase the success rate of drug development. I would like to take this opportunity to thank the organizers for inviting me to speak at this conference. It is an honor to share my research and experiences with such a distinguished audience. In conclusion, I wish you all a productive and engaging conference, and I look forward to the discussions and collaborations that will emerge from this event. Thank you. Special Keynote Speaker's Message Dr. Amit Pandit Research, Berlin, Germany Dr. Sandeep Kailey Drug Control Officer, Baran, Rajasthan Guest of Honour Message

23 Souvenir Souvenir 24 Keynote Speaker Dr. Kalandar Ameer Professor, School of Medicine, College of Health & Medical Sciences, Jigjiga University, Etiopia Mr. Ajay Pathak Licensing Authority & Drug Controller, Jaipur, Rajasthan Dr. Shashi Alok Editor-in-Chief, IJPSR & Associate Professor, Bundelkhand University, Jhansi, Madhya Pradesh Pro. (Dr.) M.K. Gupta Dean Pharmacy, CP University, Kota Convener Mr. Saurabh Chaturvedi Registration Committee Dr. Manoj Kr Jangid Mr. Rahul Kr. Ancheria Stage / Venue / Media Committee Mrs. Harshita Jain Ms. Mithlesh Malviya ORGANIZING COMMITTEE Ms. Sakshi Shukla Ms. Deepika Rathore

25 Souvenir Souvenir 26 Dr Dr. Harsh Gulati . Anita Singh Dr. Meenakshi Dr. Prateek Sharma Scientific Committee Mr. Abhishek Nagar Mr. Nitin Nama Dr. Abid Hussain Dr. Ashutosh Kumar Dr Dr. Aman Kr. Sharma . Surbhi Singh Dr. Pushpendra Yadhuvanshi FOOD COMMITTEE Mr. Chetan Dubey Mr. Rahul Sharma Dr. Ashish Jorasia Dr. Vivek Jain Dr. V.K. Boyal SN Organization Director 1. Skinlarility Mr. Hitesh Patel 2. Kavit essentials Mr. Kapil Jain 3. Shir Balaji Herbal Hitech Farms Mr. Deepesh Nagar 4. Swarth Pathology Lab Mr. Chetan Singh 5. Prakash Hospital Dr. Amit Saxena Sponsors

27 Souvenir Souvenir 28 SN Abstract Code Authore Name Title of Abstract 1 ICLTIPB/PH/2023/1001 Poonam Burman Diversity of Pathogens and Diseases associated with Selected Field Crops at Bathinda Region of Punjab, India 2 ICLTIPB/PH/2023/1002 Manvendra Singh Hepatoprotective Potential of Tinospora cordifolia and Eclipta alba Extract Compared with Market Formulation 3 ICLTIPB/PH/2023/1003 Pranjal Sachan A Review of the Optimization and Characterization of Phytosome 4 ICLTIPB/PH/2023/1004 Anamika Singh Design, Synthesis and Biological Activity of New Substituted Pyrimidine Derivative as ?-Glucosidase Inhibitory Activity 5 ICLTIPB/PH/2023/1005 Pradeep Kr Vishwakarma A Combination Therapy for Anti-Microbial Resistance in Skin Infection - Eradication By Nano Ointment 6 ICLTIPB/PH/2023/1006 Loushambam Samananda Sex Dimorphism in Circulating Leptin Concentrations in Singh Relation to BMI 7 ICLTIPB/PH/2023/1007 Nivedita Gupta Use of Biotechnological Approaches to Enhance Properties of Vegetable Crops 8 ICLTIPB/PH/2023/1008 Mustapha Abubakar Field Evaluation of the Potential of Cow Based Products in the Management of Whitefly (Bemicia Tabaci G.) Population on Eggplant (Solanum Melongena L.) 9 ICLTIPB/PH/2023/1009 Ankit Shukla Anti-Inflammatory Nature of Nyctanthes Arbor Tristis 10 ICLTIPB/PH/2023/1010 Mohd Aftab Siddiqui Cardioprotective Effects of Lavandula Stoechas in Isoprenaline induced Myocardial Necrosis in Rats 11 ICLTIPB/PH/2023/1011 Anjali Soni Tumor-Targeted Drug Delivery System 12 ICLTIPB/PH/2023/1012 Priyanka Yadav Future Prospects for Cancer Immunotherapy 13 ICLTIPB/PH/2023/1013 Ankit Kulpare Microspheres as a Novel Drug Delivery System 14 ICLTIPB/PH/2023/1014 Amreen Qureshi Gold Nanoparticles in Cancer:-Treatment, Diagnosis & Detection 15 ICLTIPB/PH/2023/1015 Dharmendra Solanki Natural Superdisintegrants- Novel Concept in Oral Drug Delivery 16 ICLTIPB/PH/2023/1016 Muskan Jain Nanosponges- A Review 17 ICLTIPB/PH/2023/1017 Naincy Jain Moringa Leaves Health Drink for Malnutrition In Children 18 ICLTIPB/PH/2023/1018 Ritu Jaiswal Detection,Treatment&Hormonaltherapy:-forInfertilityDuetoPCOS 19 ICLTIPB/PH/2023/1019 Prachesh Pandey Formulation and Characterization of Matrix Dispersion Type Transdermal Patch of Metoprolol Succinate 20 ICLTIPB/PH/2023/1020 Chandra Shekhar Sharma TransdermalEffect ofTamoxifenCitrate on InducedBreastCancer 21 ICLTIPB/PH/2023/1021 BeenaRathore LiposomalDrugDeliverySystem:NewerApproaches 22 ICLTIPB/PH/2023/1022 Rishabh Gaur A Comprehensive Review on Peptic Ulcer 23 ICLTIPB/PH/2023/1023 Kunal Suryavanshi Pathophysiological Status, Molecular Pathways and Treatment Updates on Huntington'S Disease 24 ICLTIPB/PH/2023/1024 Harsh Jain A Study of Plants using Medicinal Properties to Treat Malaria: A Clinical Review 25 ICLTIPB/PH/2023/1025 Karan Agrawal Formulation and Evaluation of Tea Tree Oil Gel 26 ICLTIPB/PH/2023/1026 Shailendra S. Suryawanshi Computer Aided Screening and In-Vitro Anticancer Activity of Bioflavonoid Fractions of Muntingia Calabura Against COLO 205 Cancer Cell Lines 27 ICLTIPB/PH/2023/1027 Alveena Ganai Comparative Efficacy of Curcumin, Curcuma Longa (Turmeric) and Nitazoxanide against Cryptosporidium Parvum Infection in Mice 28 ICLTIPB/PH/2023/1028 Vikram Pandey Biodiversity & Conservation of Management INDEX 29 ICLTIPB/PH/2023/1029 Ashi Patel A Review on Food Technology 30 ICLTIPB/PH/2023/1030 Anamika Rathore A Survey on the use of Medicinal Plants in the Treatment of Myocardial Infarction Disease 31 ICLTIPB/PH/2023/1031 Innocent Sutnga Cell Membrane-Derived Vesicles for Therapeutic Drug Delivery 32 ICLTIPB/PH/2023/1032 Kripa Shankar Singh Derivatization of Flavanoid and Evalution of Anti-Inflammatory Activity on Experimental Animals 33 ICLTIPB/PH/2023/1033 Akanksha Patel Development and Evaluation of Voriconazole Loaded Nanostructured Lipid Carriers for Topical Mycoses 34 ICLTIPB/PH/2023/1034 Akash Sharma Chemistry of Traditional Medicinal Products used as a Crucial Source for the Discovery of Potential Anti-Tubercular Drugs 35 ICLTIPB/PH/2023/1035 Varsha Yadav Molecular Docking of Phytoconstituents of Abelmoschus Esculents for Antidiabetic Activity 36 ICLTIPB/PH/2023/1036 Sheela Suthar Patents in Pharmaceutical Research & Development 37 ICLTIPB/PH/2023/1037 Mohammad Azhar Importance of Regulatory Affairs and Intellectual Property Rights (IPR) in Pharmaceutical Industry 38 ICLTIPB/PH/2023/1038 Bimal Debbarma Design and Evaluation of Losartan Potassium Sustained and Hydrochlorothiazide immediate Release Drug Formulation 39 ICLTIPB/PH/2023/1039 Ruqaiya Jamal Development of Highly Predictive QSAR Models By Using KNN And MLR Methods For Anti-Inflammatory Activity of Thiazole Derivatives 40 ICLTIPB/PH/2023/1040 Sudhanshu Mishra Formulation and Evaluation of Transdermal Patch of Acetyl Keto Boswellic Acid for Treatment of Arthritis 41 ICLTIPB/PH/2023/1041 Pravin K. Bhoyar Design and Optimization of Fast Dissolving Solid Oral Formulations of Etodolac using Solvent Free Technology by 32 Factorial Design 42 ICLTIPB/PH/2023/1042 Anish Kumar Pharmacological Assessment of Herbal Suspension for Anti Parkinson Activity in Rat 43 ICLTIPB/PH/2023/1043 Sushant Chaudhary Formulation and Evaluation of Solid Lipid Nanoparticles of Baclofen for Improvement of Muscle Relaxant Action 44 ICLTIPB/PH/2023/1044 Gaurav Tailor Drug Delivery from the Hydrogels 45 ICLTIPB/PH/2023/1045 Jitendra Kr. Singh Review Article on Nicotine Originated (Active And Passive Diseases At 21Century) 46 ICLTIPB/PH/2023/1046 Patil Adarsh Arun Computer Aided Investigation of Physicochemical Properties and Drug Likeness Profile of Selected Vitamins and Related Analogues Drug Likeness Profile of Selected Vitamins and Related Analogues 47 ICLTIPB/PH/2023/1047 Ronak Dsouza Computational Study of Phytochemistry and Drug Likeness Properties of Selected Plant Compounds from Aloe Vera 48 ICLTIPB/PH/2023/1048 Bhujabal Singh Parihar A Case Study on Citrus Orchards Pests and Their Management 49 ICLTIPB/PH/2023/1049 Rohit Kumar Singh Formulation, Evaluation and Anti-Bacterial Activity of Ceftazidime and Clove Oil-Loaded Solid Lipid Nanoparticle 50 ICLTIPB/PH/2023/1050 Shivani Tyagi Preparation of Nanoemulsion Loaded with Antiretroviral Drug for the Management of Neuroaids 51 ICLTIPB/PH/2023/1051 Anusha Jain Formulation and Evaluation of Nano-Cocrystal of an Anti-Hyperlipidemic Drug forthe Management of Hyperlipidemia 52 ICLTIPB/PH/2023/1052 Kalyani U. Chande LC-MS Determination of Bioactive Constituents of Glycyrrhiza Glabra Root Extract 53 ICLTIPB/PH/2023/1053 Ankita Alice Singh Development and Evaluation of Phage Therapy Against Mrsa (Biofilm Forming) in Experimental Animal Model

29 Souvenir Souvenir 30 54 ICLTIPB/PH/2023/1054 Prathamesh Magadum In-Silico Prediction of Drug Likeness Properties of Selected Phytochemicals of Azadiractha Indica 55 ICLTIPB/PH/2023/1055 Shreyansh Investigation of Physicochemical Properties of Selected Phytoconstituents of Arjuna by Computer AidedDrug Design Tools 56 ICLTIPB/PH/2023/1056 Sunita Roy Application of Herbal Technology in Memory Enhancement to Control Dementia Caused by Alzheimer Disease 57 ICLTIPB/PH/2023/1057 Virashri Dhumal Formulation & Evaluation of Polyherbal Extract Face Serum 58 ICLTIPB/PH/2023/1058 Pragya Sharma Ligand Based Pharmacophore Modelling, Virtual Screening and Molecular Docking to Identify Novel SCD Inhibitors for the Treatment of Metabolic Syndrome 59 ICLTIPB/PH/2023/1059 Kiran Sharma Impact of Endophytic Fungi Isolated from Ajuga Bracteosa Wall. Ex Benth. on Anti-Oxidant Potential of Plant Perilla Frutescens (L.) Britton 60 ICLTIPB/PH/2023/1060 Vishal S. Adak Preliminary Phytochemical Screening and HPTLC Finger Printing Analysis Of Seeds Extracts of Vernonia Anthelmintica (L) and Trachyspermum Ammi (L) 61 ICLTIPB/PH/2023/1061 Diksha Sharma Antioxidant Potential of Urtica Dioica Leaves Growing Wild in different Forest Regions of Himachal Pradesh Analysis of Anti-Inflammatory Activity of Jasminum 62 ICLTIPB/PH/2023/1062 Mehak Officinale L. And Erigeron Annuus (L.) Pers. for the Treatment of Diabetes Mellitus in Himachal Pradesh Of Western Himalayas 63 ICLTIPB/PH/2023/1063 Ritika Dadhwala Evaluation of Antioxidants of Cotoneaster Microphyllus Wall. Ex Lindl. Leaves and Fruits Growing in Distt. Shimla of H.P. 64 ICLTIPB/PH/2023/1064 Madan Lal Review on Adulterants in the Ayurvedic Formulation 65 ICLTIPB/PH/2023/1065 Bidyut Bikash Laskar A Review on Artificial Intelligence in New Drug Development: Present Status and Future Prospects Current Trends in Pharmaceutical Analysis to Promote 66 ICLTIPB/PH/2023/1066 Achangliu Pamai Contemporary Drug Discovery by In- Silico Profiling of Drugs and Related Substances 67 ICLTIPB/PH/2023/1067 Shubhi Yadav Formulation and Evaluation of Topical Hydrogel of Luliconazole Loaded Beta Cyclodextrin Nanosponges 68 ICLTIPB/PH/2023/1068 Nitin Shukla Thymus Vulgaris: A Phytopharmological Review 69 ICLTIPB/PH/2023/1069 N.Indumathi Innovation Technology for Efficiency in Healthcare System 70 ICLTIPB/PH/2023/1070 N.Indumathi Innovation Technology of Artificial Intelligence for Improving Efficiency in Healthcare System 71 ICLTIPB/PH/2023/1071 Navjot Kaur Systematic Comparative Analysis of Pharmacognostic Profile of Some Species of Genus Euphorbia 72 ICLTIPB/PH/2023/1072 Liza Boro Production of Natural Disinfecting Agents from Garbage Enzyme and Comparison of their Efficacy with Commercially Available Products 73 ICLTIPB/PH/2023/1073 S. A. Chavhan Comparative Qualitative Analysis of Yasad Bhasma with Classical and Modern Parameters 74 ICLTIPB/PH/2023/1074 Arshi Atiya Synthesis, Biological Evaluation of New Quinoline Derivatives as a Potent Anti-Inflammatory Activity 75 ICLTIPB/PH/2023/1075 Sanjay Kumar Patel Formulation and Evaluation of Baclofen Loaded Liposomal Hydrogel 76 ICLTIPB/PH/2023/1076 Brundha S N In Silico Study on 1,3,4 Thiadiazole Derivatives Tethered with Isoniazid on HER2 for Anti Breast Cancer Activity 77 ICLTIPB/PH/2023/1077 Swanand Kulkarni Nano Emulsion Based Carotenoids Extraction 78 ICLTIPB/PH/2023/1078 Nikita Panwar To Estimate Eugenol in Pure and Myristica Fragrans Seed Extract, a Forced Degradation Study using the HPTLC Method was Conducted 79 ICLTIPB/PH/2023/1079 Zarnain Fatima Therapeutic Potential of Quercetin Loaded Topical Nano-Formulations: A Systematic Review 80 ICLTIPB/PH/2023/1080 Awate Pravin Formulation and Evaluation Etizolam Loaded Polymeric Nanoparticles in Treatment of Anxiety Disorders: Research 81 ICLTIPB/PH/2023/1081 Neha Rao 3-D Printing: Innovative Aspects in Pharmaceutical Industry 82 ICLTIPB/PH/2023/1082 Pavan Kumar Yadav Preparation and In-Vitro Antidiabetic Evaluation of Raphanus Sativus Extract-Loaded Nanoparticles 83 ICLTIPB/PH/2023/1083 Snehal S. Manekar Potential use of Indoor Plants to Ameliorate Indoor Air Quality: An Overview 84 ICLTIPB/PH/2023/1084 Azaz Ahmad Current Trends and Future Strategies in the Diagnosis &Management of Uterine Fibroids 85 ICLTIPB/PH/2023/1085 Sachin Kumar Agrahari Pharmacological Study on Antidiabetic and Antioxidant Activity of Methanolic Extract of Leaves of Achyranthes Aspera and Phaseolus Vulgaris Linn. 86 ICLTIPB/PH/2023/1086 Akanksha Pandey A Tool for Evaluating the Economic Impact of Drug Therapies:Pharmacoeconomics 87 ICLTIPB/PH/2023/1087 Harshita Mittal Robotic Technology in Paediatric Neurorehabilitation 88 ICLTIPB/PH/2023/1088 Rahul Arun Jagtap Analysis of Acetylenehexacarbonyldicobalt Complexes as a Potential Anti-Cancer Agent Through IR, NMR And GC-MS Techniques 89 ICLTIPB/PH/2023/1089 Ruchi Verma Estimation of Anidulafungin and Related Compounds in Intravenous Dosage form by RP-HPLC Method 90 ICLTIPB/PH/2023/1090 Kunal Verma Nanoemulsion for the Management of Neuroaids by ARV Therapy: Development and Evaluation 91 ICLTIPB/PH/2023/1091 E. Selvakumari Design, Development and Characterization of Kalanchoe Gastonis Bonnieri (Crassulaceae) including DNA Authentication Studies 92 ICLTIPB/PH/2023/1092 Deepak Chandra Joshi Pharmacological Evaluation of Leafs Extract of Ficus Auriculatalour for Anti Ulcer Activity 93 ICLTIPB/PH/2023/1093 Manmohan Sharma Pd-Catalysed [3+2]-Cycloaddition Towards The Generation of Bioactivebis-Heterocycles/Identification of COX-2 Inhibitors Via Insilicoanalysis 94 ICLTIPB/PH/2023/1094 Prateek Porwal Phytochemistry, Medicinal uses along With it's Biological Activities of Amoora rohituka (Meliaceae) Leaves 95 ICLTIPB/PH/2023/1095 Surinder Kumar A Biological Production of Copper, Iron, and Nickel Nanoparticles and its Potential Uses and it's Potential uses 96 ICLTIPB/PH/2023/1096 Afsha Khan Neuroprotective Effect of Flavonoid in 3 NPA Induced Experimental Animal Model Of Hd Phenotype Via Regulating NRF2/ NF-KB Signaling Pathway 97 ICLTIPB/PH/2023/1097 Ankita Agarwal Beneficial Electrolytes Present in the Juice of Cocos nucifera 98 ICLTIPB/PH/2023/1098 Nayana R. Jawale Design of Novel 2-Mercaptobenzimidazole Derivatives for the Treatment of Prostate Cancer: An In-Silico Approach 99 ICLTIPB/PH/2023/1099 Nayana R. Jawale Identification of Novel 2-Mercaptobenzimidazole Derivatives for the Treatment of Breast Cancer: A Computational Approach 100 ICLTIPB/PH/2023/1100 Khushal Garg Scientific Update on Alzheimer's Disease

31 Souvenir Souvenir 32 101 ICLTIPB/PH/2023/1101 Sushila Gupta Phytochemical Screening and In Vitro And In Vivo Antioxidant Potential of Jasminum Sambac Flowers 102 ICLTIPB/PH/2023/1102 Yatin Kumar Scientific Update on Myocardial Infarction 103 ICLTIPB/PH/2023/1103 Anuradha Pharmacognostic & Phytochemical Evaluation of Rumex Acetosa 104 ICLTIPB/PH/2023/1104 Akriti Yadav Hebal Gel Shampoo Enriched with Bitter Melon and Vitamin E 105 ICLTIPB/PH/2023/1105 Waibiangki Lyngdoh Stability- Indicating Method Development and Validation of Glycyrrhizin using RP-HPLC-DAD: Quantification of Glycyrrhizin in Glycyrrhiza Glabra Extract 106 ICLTIPB/PH/2023/1106 Jugal Sutradhar Formulation and Evaluation of Phytosome-Loaded n-Hexane Extract of Flowering Buds of Mesua ferrea Linn. Gel 107 ICLTIPB/PH/2023/1107 Vinay Kumar Siroliya Phytochemistry, Medical uses along with it's Biological Activity of Flower of Nymphaea alba (Nymphaeaceae) 108 ICLTIPB/PH/2023/1108 Bharat Lal A General Case Study: Healthcare Data Visualization on Tuberculosis in M.P. (District- Satna) 109 ICLTIPB/PH/2023/1109 Harshika Gupta Review on Preventing Undue Exertion Utilizing Physiogenix Cut Ingedgeattechnology for Sports Concussions 110 ICLTIPB/PH/2023/1110 Nabila Mohamad Thymoquinone Estimation in Seed Powder Extracts of Taleuzzaman Nigella sativa by HPTLC Analytical Technique 111 ICLTIPB/PH/2023/1111 Priya Chourasia The Role of Clove Oil in the Treatment of Topical Fungal Infection: A Review 112 ICLTIPB/PH/2023/1112 Ashish Miglani Therapeutic Potential of Hemp Seed Oil: A Review 113 ICLTIPB/PH/2023/1113 Dhruva Garg Recent Approaches for Cancer Treatment through Gene Therapy 114 ICLTIPB/PH/2023/1114 Satyam Sharma BGT222 Loaded Solid Lipid Nanoformulation Suppresses the Migration and Invasion in Human Colon Cancer CACO-2 Cells Via Modification of Raptor, HDAC, DNMT-1, Oxidative and Apoptotic Cascades 115 ICLTIPB/PH/2023/1115 Raunak Mishra Formulation and Evaluation of Poly Herbal Syrup for Treatment of Dengue 116 ICLTIPB/PH/2023/1116 Akanksha Mishra Formulation and Characterization of Herbal Extract Containing Lip Balm for the Treatment of Lip Pigmentation 117 ICLTIPB/PH/2023/1117 Ajeet Kumar Rapid Dissolving Film for Novel Drug Delivery Systems: A New Route for Quick Migraine Relief 118 ICLTIPB/PH/2023/1118 Hanumant Sharma Formulation Development and Evaulation of Atorvastatin Tablet by using Finger Millet (Eleusine corocana) Starch as Natural Disintegrant 119 ICLTIPB/PH/2023/1119 Abhishek Marwari Pharmacological Screening of Sanseveria cylindrica in Management of Obesity 120 ICLTIPB/PH/2023/1120 Chhavi Verma Pharmacological Effects of Extract of Carica papaya Leaves 121 ICLTIPB/PH/2023/1121 Abhay Pratap Singh Formulation Development & Evaluation of Dermatological Polyherbal Gel for Acne Treatment 122 ICLTIPB/PH/2023/1122 Anamika Gautam Interaction of Antihypertensive Drug with Garlic in Rat 123 ICLTIPB/PH/2023/1123 Neha Singh A Review on the Methods of Preparation of Nanoparticles and Applications 124 ICLTIPB/PH/2023/1124 Lalit Kumar Evaluation of Chenopodium Album Leaves Extracts for Nootropic Activity Potential in Wistar Rats 125 ICLTIPB/PH/2023/1125 Sarita Rani Memory Enhancing Activity of Dracaena trifasciata Leaves Extracts on Scopolamine Induced Amnesia in Wistar Rats 126 ICLTIPB/PH/2023/1126 Ajay Kumar Evaluation of the Antihypertensive Effect of Rumex Nepalensis Leaves Extracts on Ethanol-Induced Hypertension in Wisar Rats 127 ICLTIPB/PH/2023/1127 Anushka Hepatoprotective Activity of the Commelina benghalensis Leaves in Ethanol-Induced Hepatotoxicity in Rats 128 ICLTIPB/PH/2023/1128 Anjali Evaluation of Antiulcer Activity of Leaves of Rubus ellipticus in Experimental Animal 129 ICLTIPB/PH/2023/1129 Ayushi Bhatnagar Preclinical Screening of Chenopodium album Leaves Extracts for Anti-Obesity Activity 130 ICLTIPB/PH/2023/1130 Ashish Kumar Determination and Evaluation of Anthelmintic Activity of the Leaf Extract of Anthocephalus cadamba MIQ 131 ICLTIPB/PH/2023/1131 Dipanshu Kumar Formulation Development and Evaluation of Tablet Containing Rosuvastatin with Neutraceutical Potential 132 ICLTIPB/PH/2023/1132 Mukul Kumar Rana Development and Evaluation of the Inclusion Complex of Gliclazide with Hydroxy-Propylbeta- Cyclodextrin 133 ICLTIPB/PH/2023/1133 Preeti Sisodia Screening ofCalotropis proceraRootsExtracts forAntidepressant and Antianxiety Potential in Swiss Albino Mice 134 ICLTIPB/PH/2023/1134 Neeraj Chauhan Solid Lipid Nanoparticle Design, Development and Evaluation for Improving the Bioavailability of Certain Anti-Hypertensive Medications 135 ICLTIPB/PH/2023/1135 Nisha Antidiabetic Activity and Phytochemical Screening of Plumbago zeylanica Leaves Extracts in StreptozotocinInduced Diabetic Rats 136 ICLTIPB/PH/2023/1136 Rajat Chauhan Development and Optimization of Self- Nano Emulsifying Drug Delivery System of Ibrutinib 137 ICLTIPB/PH/2023/1137 Ankita Patel Preparation and Standardization of Polyherbal Powder for the Management of Hypercholestrolemia Disease 138 ICLTIPB/PH/2023/1138 Rahul Kumar Pandey Formulation and Standardization of Herbal Extract Containing Multi-Purpose Cream 139 ICLTIPB/PH/2023/1139 Jai Prakash Sharma Biodiversity Conservation and Environmental Perspectives: A Geographical Analysis 140 ICLTIPB/PH/2023/1140 Sangeeta Mathur Demand of New Policies on Pharmaceutical Industry 141 ICLTIPB/PH/2023/1141 Reeta Saxena Social Policies in Pharmacy 142 ICLTIPB/PH/2023/1142 Sachin Kumar Phytochemical Analysis and Antibacterial Properties of Butea monosperma 143 ICLTIPB/PH/2023/1143 Vijay Tambe Synthesis And Anti-Inflammatory Activity of 2- Amino Benzothiazole 144 ICLTIPB/PH/2023/1144 Uday Suryawanshi HIV Activities of 2-Amino Benzothiazole 145 ICLTIPB/PH/2023/1145 Aayushi Tyagi Anxiolytic Activity of Sanjeevani bryopteris using Experimental Animal Model 146 ICLTIPB/PH/2023/1146 Neeta Audichya Urmila'S Role in Shaping the Destiny of Ayodhya: an Analysis of Her Character in the Context of Politics and Power Dynamics in Ancient India 147 ICLTIPB/PH/2023/1147 Anjali Dixit Legal Regulations of Traditional Medicines in India 148 ICLTIPB/PH/2023/1148 Anjali Jain Emulgel Formulation- An Effective Approach for Treatment of Skin Diseases 149 ICLTIPB/PH/2023/1149 Rakhi Methi Thioglycolic Acid as Stabilizer 150 ICLTIPB/PH/2023/1150 Deepika Aggarwal Nanoformulations Approach for Improved Stability and Efficacy of Herbal Drugs 151 ICLTIPB/PH/2023/1151 Munajir Rajja Artificial Intelligence in Pharmacy and Bioscience 152 ICLTIPB/PH/2023/1152 Devangi Solanki A Review: Therapeutic Potential of Flavonoid and Evaluation of Herbal Gel for Wound Healing

33 Souvenir Souvenir 34 153 ICLTIPB/PH/2023/1153 Pankaj Gupta 1,3,4-Oxadiazole Derivatives As Antimicrobial Agent Via DNA Gyrase Inhibiton 154 ICLTIPB/PH/2023/1154 Monika Pandey Comparative Study of Physico-Chemical and Phytochemical Screening of Some Selected Antidiabetic Medicinal Plant 155 ICLTIPB/PH/2023/1155 Sangeeta Verma Quinoline Hydrazide/Hydrazone Derivatives: Antibacterial Potential, Structure Activity Relationship & Mechanism of Action 156 ICLTIPB/PH/2023/1156 Pradeep Swarnkar Efficient Method for Determination of Organic Impurities in Alogliptin and Metformin Dosage form by Using RP-HPLC 157 ICLTIPB/PH/2023/1157 Somya Gupta Alternatives to Animal Research 158 ICLTIPB/PH/2023/1158 Ved Prakash Jadaun Have You Know about Off Label use of Drug? 159 ICLTIPB/PH/2023/1159 Preeti Choudhary An Overview on Nanostructured Lipid Carrier Based Drug Delivery System 160 ICLTIPB/PH/2023/1160 Rita Yadav Artificial Intelligence in Pharmacy and Bioscience 161 ICLTIPB/PH/2023/1161 Varsha Yadav Pharmacognostic and Phytochemical Studies of Leaves of Syzgium cumini 162 ICLTIPB/PH/2023/1162 Garvita Chaudhary Joshi Anti-Inflammatory Activity Determination of A Polyherbal Formulation Containing Tinosporia cordifolia, Moringa oleifera and Allium sativum 163 ICLTIPB/PH/2023/1163 Tulsi Tak Microneedles : Recent Development in Vaccine Through Transdermal Drug Delivery System 164 ICLTIPB/PH/2023/1164 Jyoti Nagar Research of Oral Pill Discovery for Insulin Drug Delivery 165 ICLTIPB/PH/2023/1165 Deepak Hada A Comparative Study on the Effect of Adsorption Parameters of Ni (Ii) in Alkaline Soil 166 ICLTIPB/PH/2023/1166 Swati Shukla Role of Phenolic Compounds in Modulating Signalling Pathways to Combat Skin Ageing 167 ICLTIPB/PH/2023/1167 A V Shrirao Protective Effects of Methanolic Extract of Acalypha Hispida Leaf on Streptozotocin Induced Diabetic Peripheral Neuropathy in Rats 168 ICLTIPB/PH/2023/1168 Manisha Sharma Soil and Water Conservation for Sustainable Agriculture 169 ICLTIPB/PH/2023/1169 S. T. Landge Improvement of Solubility and Oral Bioavailability of Cefuroxime Axetil by Hot Melt Extrusion Technique 170 ICLTIPB/PH/2023/1170 Archi Gupta Tirzepatide New Era of Dual Targated Treatment for Diabetes and Obesity 171 ICLTIPB/PH/2023/1171 Mridula Chauhan The Role and Future Prospect of AI-Based Neural Network Models in the Diagnosis of Diabetes Related Peripheral Neuropathy 172 ICLTIPB/PH/2023/1172 Gaurav Kamewal To Observe and Isolation and Treatment of Mycobactrium Tuberculosis 173 ICLTIPB/PH/2023/1173 Lucky Ali An Overview of Application of Nutraceutical in Human Disease 174 ICLTIPB/PH/2023/1174 Amrik Dey Health Benefits of Daucus carota (Carrot): A Review 175 ICLTIPB/PH/2023/1175 Afsha Khan Neuroprotective Effect of Flavonoid in 3 NPA Induced Experimental Animal Model of HD Phenotype via Regulating NRF2/ NF-KB Signaling Pathway 176 ICLTIPB/PH/2023/1176 Devansh Vijayvargiya Artificial Intelligence in Pharmacy 177 ICLTIPB/PH/2023/1177 Pooja Bhatnagar Statistical Analysis of Sound Pollution Pre and Post Covid Period in Mansarover Area Jaipur (Rajasthan) 178 ICLTIPB/PH/2023/1178 Prakash Yadav SGs Of Kelkhoyra Shiv Temple, Jhalawar - Ideal Centre for Biodiversity Conservation 179 ICLTIPB/PH/2023/1179 Shyam Baran Singh To Observe Depression, Mental Illness, Therapy & Treatment 180 ICLTIPB/PH/2023/1180 T. Naga Aparna Melt Granulation - A Promising Approach for Improving the Bioavailability of Poorly Soluble Drug - Sorafenib 181 ICLTIPB/PH/2023/1181 Lokesh Singh, Syndromes Associated with Antibiotics 182 ICLTIPB/PH/2023/1182 Rakesh Kumar Niranjan Phytochemical Screening, In Vitro Anti-Oxidant Activity & in Vitro Anti-Diabetic Activity of Leaves Of Paeoniaemodi Extract 183 ICLTIPB/PH/2023/1183 Shalini Formulation Development & Evaluation of Mucoadhesive Buccal Film of Betamethasone for Oral Ulcer Treatment 184 ICLTIPB/PH/2023/1184 Akshat Sharma Drug Delivery System 185 ICLTIPB/PH/2023/1185 Rahul Suman Drug Discovery and Its Development 186 ICLTIPB/PH/2023/1186 Arati Rajput Development and Evaluation of Emulgel of Celecoxib by using Natural Oil 187 ICLTIPB/PH/2023/1187 Deepak Kumar Gupta A Brief Assessment of Recent Improvements in Nonionic Surfactant-Based Nano-Vesicles (Proniosomes) for Improving Transdermal Drug Delivery 188 ICLTIPB/PH/2023/1188 Ashish Jorasia Impact of Health issues in the Pharmaceutical Field in Modern Times in Rajasthan 189 ICLTIPB/PH/2023/1189 Om Sugandhi Evaluation of Oroxylum indicum on Alloxan Induced Rats for Antidiabetic Activity 190 ICLTIPB/PH/2023/1190 Ravi Ranjan Financial Structure of the Pharmaceuticals Industry 191 ICLTIPB/PH/2023/1191 Dipak V. Bhusari Formulation and Comparison Between Two Methods for 5-Fluorouracil-Loaded Chitosan Microspheres 192 ICLTIPB/PH/2023/1192 Jyoti Peswani A Study on Challenges in Implementation of GST with Respect to Restaurant Industry 193 ICLTIPB/PH/2023/1193 Fayeza Hakimuddin Management of short term capital in leather industries Sonkachwala 194 ICLTIPB/PH/2023/1194 Sakshi Shukla Structural Electronic and Optical Properties of SiO2 Materials 195 ICLTIPB/PH/2023/1195 Anil Kumar Meena In vitro antioxidant and antidiabetic activity of hydro-alcoholic extract of selected common agricultural weed plants 196 ICLTIPB/PH/2023/1196 Ashutosh Kumar A Review Paper on "Consumer Behaviour in Tourism: Concepts, In?uences and Opportunities" 197 ICLTIPB/PH/2023/1197 Abhishek Nagar Enrichment of Saponin content in the washes of roots of Chlorophytum borivilianum 198 ICLTIPB/PH/2023/1198 Harshita Jain Isoniazid and Rifampicin induced hepatoprotective activity of roots and leaves extract of Picrorhiza kurroa 199 ICLTIPB/PH/2023/1199 Nitin Nama Formulation and Characterization of Bauhinia racemosa extract loaded nanoemulsion by box Behnken Design 200 ICLTIPB/PH/2023/1200 Chetan Kumar Dubey Evaluation of Toxicological and Anti-anxiety effect of Gingerol 201 ICLTIPB/PH/2023/1201 Saurabh Chaturvedi A Review on Esters & Fatty acids from Pleurospermum densiflorum 202 ICLTIPB/PH/2023/1202 Riya Yogi AClinicalOverviewofInsulinPumpTherapy forManagement ofDiabetes 203 ICLTIPB/PH/2023/1203 Shabenoor Siddiqui Formulation and Evaluation of Resveratrol loaded Microparticles or Controlled Drug Delivery 204 ICLTIPB/PH/2023/1204 Mithlesh Malviya Children's Drug Abuse: An Increasing Problem in India 205 ICLTIPB/PH/2023/1205 Jay Prakash Srivastava Hindu Women'S Rights To Property: An Indian Approach After Independence 206 ICLTIPB/PH/2023/1206 Ankita Nawal The Ethical Implication of The Ayurvedic Cosmetic Products - A Pestle Analysis Study of The Indian Ayurvedic Cosmetic Sector With A Special Focus on Indian Youth 207 ICLTIPB/PH/2023/1207 Kunal Verma Nanoemulsion For The Management of Neuroaids By Arv Therapy: Development And Evaluation

35 Souvenir Souvenir 36 208 ICLTIPB/PH/2023/1208 Ankita Malviya Formulation And Characterization Of Gastroretentive Superporous Hydrogel Tablets Of Labetalol Hydrochloride 209 ICLTIPB/PH/2023/1209 Navneet Kumar Verma In-Vitro Evaluation Of An Anti-Fungal Nail Lacquer Containing Miconazole Nitrate 210 ICLTIPB/PH/2023/1210 Ankur Yadav Pharmacological Applications Of Moringa Oleifera (Medicinal Plant) 211 ICLTIPB/PH/2023/1211 Shiwani Jaiswal Pharmacological Activity of Fluoxetine and Fluoxetine Derivatives 212 ICLTIPB/PH/2023/1212 Vikas Yadav Pharmacological Importance of Flax Seed (Linum Usitatissimmum L.) 213 ICLTIPB/PH/2023/1213 Neha Srivastava Pharmacological Screening of Chrozophora Tinctoria Leaves Extract As Antidiabetic Effect In Rat 214 ICLTIPB/PH/2023/1214 Neelam Yadav Enhancement of Natural Drug Aqueous Solubility By Using Various Method 215 ICLTIPB/PH/2023/1215 Sandeep Kumar A Comprehensive Study on the Impact of Performance Management Systems on Pharmacy Staff Motivation & Job Satisfaction in Rajasthan 216 ICLTIPB/PH/2023/1216 Aditi Gaur Assessing the Effectiveness of Pharmacists' Medication Therapy Management in Improving Patient Outcomes & Reducing Healthcare Expenditures: A Comprehensive Review 217 ICLTIPB/PH/2023/1217 Divyendu Sen Study of Medicinal Plants of Gagron Fort and Its Environs 218 ICLTIPB/PH/2023/1218 Kunal Rohira Compulsory Licensing Of Patent In India: Balancing Intellectual Property Rights And Public Health Concerns 219 ICLTIPB/PH/2023/1219 Shumayel Hasan Molecular Bottlebrush Prodrugs As Mono-And Triplex Combination Therapies For Multiple Myeloma 220 ICLTIPB/PH/2023/1220 K. Kranthi Kumar Design and Characterisation of Tamoxifen Nanosponges for Targeted Drug Delivery 221 ICLTIPB/PH/2023/1221 Rahul Suman Drug Discovery and its Development 222 ICLTIPB/PH/2023/1222 Parth Gurjar Food Technology 223 ICLTIPB/PH/2023/1223 Damini Pareta Artificial Intelligence in Physiotherapy 224 ICLTIPB/PH/2023/1224 Shagun Gupta Drug Delivery System 225 ICLTIPB/PH/2023/1225 Jyoti Nagar Research of Oral Pill Discovery for Insulin Drug Delivery 226 ICLTIPB/PH/2023/1226 Ravi Gupta A Review on Anti-Ulcer Activity from Pistia Stratiotes 227 ICLTIPB/PH/2023/1227 Shubhanshu Singh A Review on Indian Medicinal Plants in Diabetes Mellitus 228 ICLTIPB/PH/2023/1228 Uttam Singh Baghel Hyphenated Techniques for Fingerprinting of Herbal Drugs 229 ICLTIPB/PH/2023/1229 Kapil Sharma Regulatory Aspects of Herbal Medicine 230 ICLTIPB/PH/2023/1230 Neha Kaithwas A Comparative Study of Statistical Analysis of Physio -Chemical Parameters of Water of Dholawad Dam and Mahi Bajaj Sagar Dam on Mahi River 231 ICLTIPB/PH/2023/1231 Roma Sharma "Old Drugs - New Methods"- A Review On Antiviral Drug Repositioning 232 ICLTIPB/PH/2023/1232 Arun jatav The effect of Neochetina eichhorniae on the Growth of Eichhornia crassipes at Ayana pond, Kota, Rajasthan DIVERSITY OF PATHOGENS AND DISEASES ASSOCIATED WITH SELECTED FIELD CROPS AT BATHINDA REGION OF PUNJAB, INDIA 1 2 Poonam Rani and Nivedita Gupta 1 2 Associate Professor, Assistant Professor, Department of Agriculture, Baba Farid College, Bathinda, Punjab, India [email protected] Abstract: The diseased sample was collected from field crops (Rice, Cotton, Maize and Sorghum) for study the diversity of pathogens during August 2022 to October 2022 at Agriculture field of Baba Farid College, Bathinda, Punjab. The identification of diseases and isolation of pathogen was conducted at the Plant Pathology Laboratory, Baba Farid College. The results revealed that total seven fungal species representing 5 fungal genera were isolated from different mentioned field crops with standard blotter and Agar plate method. The percent infection of identified Bipolaris sarokiniana (Helminthosporium sativum), Curvularia lunata, Fusarium oxysporum, Aspergillus spp. and Alternaria spp fungal species were recorded which vary from 0 to 58.3±2.60 and 0 to 56.6±4.05 in blotter paper and agar plate method respectively. It was observed that infection percentage of Bipolaris sarokiniana (Helminthosporium sativum) Fusarium oxysporum, Aspergillus flavus and Fusarium oxysporum were predominant with value of (58.3±2.60) and (56.6±4.05), (50.3±1.85) and (47.3±2.02), (29.3±1.76) and (30.0±2.64) in Standard blotter and Agar plate method respectively, as compared to other species i.e. Alternaria alternata, Aspergillus niger, Aspergillus. fumigates and Curvularia lunata. Out of eight fungicide with 250ppm, 500ppm, 750ppm, 1000ppm and 2000ppm concentration, tested under in vitro condition, Cabriotop providing 100% growth inhibition at all the concentration followed by captaf (94.58%), Indofil Z-78 (93.53%), Amistar (86.37%), Antracol (84.86%) and Dithane M-45 (84.61%). The moderate inhibitory response due to Kavach (70.19%) and Milstin (68.16%) observed at lower concentration levels, which increased appreciably with the increase in concentration levels. This study encourage further studies on identification of proper control measures against isolated fungi in vegetable crops. Keywords:Fungi, Diversity, Percent infection, Vegetables. HEPATOPROTECTIVE POTENTIAL OF TINOSPORA CORDIFOLIA AND ECLIPTA ALBA EXTRACT COMPARED WITH MARKET FORMULATION ICLTIPB/PH/2023/1002 Manvendra Singh Department of Research, Career Point University, Kota, Rajasthan. [email protected] Abstract: In present research randomized open experimental study design was used, the study was conducted over the duration of 3years using 120 Rabbits. The animals were divided in 12 groups of 10 animals each. Oxidative stress was induced with Paracetamol. The sample size was calculated by using formula. All the drugs were administered orally as the s chedule from immedi atel y after Pa r a cet amol administration, for 7 days continued. The blood sample were withdrawn from the marginal ear vein at 0,2,15,30,45,60 and 90 days. The single dose of all antioxidant under study including Liv-52 administered immediately after Paracetamol administration was found to be less effective as compared to once daily administration for seven days. On comparisons of the efficacy of antioxidants used in this study apparently Tinospora cordifolia was found to be most effective with respect to extent in decreasing MDA, ALT, AST levels and increasing SOD levels. Tinospora cordifolia also brought MDA, SOD, ALT and AST levels to the control values on 45 days. Liv-52 produced more or less same results. Eclipta alba, Vitamin C reached the control values on 60 days. Keywords: Tinospora cordifolia, Paracetamol, Eclipta alba, Vitamin C, Liv-52 ICLTIPB/PH/2023/1001

37 Souvenir Souvenir 38 Abstract: Diabetes mellitus is a common, chronic disease mainly characterized by the body's lack of ability to control blood sugar resulted into chronic hyperglycemia. Carbohydrate digestive enzymes, found in the brush border of the intestine, play the catalyzing role in breaking down the long-chain polysaccharides into absorbable monosaccharide units. Among these enzymes, αglucosidase inhibitors preventing the carbohydrate digestion and glucose release in bloodstream efficiently control T2DM. Several pyrimidine derivatives have been synthesized and widely screened for their biological activities. benzimidazole and pyrimidine moieties have received much attention in developing new therapeutic agents. more potent, less toxic αglucosidase inhibitors is highly demanding. All the computational studies were Performed on a HP running on Core-i5 processor CS Chem Office 2008125, VALSTAT126. Molecular Docking Study: All the 10 alpha glucosidase inhibition were subjected to molecular docking using the MOLEGRO Virtual Docker 6.0. Ten compounds were selected of pyrimidine ring derivative on the basis of literature review and docked against α-glucosidase enzyme and co-crytallized with (PDB code:3A4A) the co-Crystallized ligand was also validated. The mol dock score and the amino acid interactions are Reported. The novel pyrimidine derivatives 1- 10 synthesized in this study are mostly active inhibitors of the α-glucosidase enzyme. The better activity of compounds 2 and 10 suggests that the presence of 3-chloro and 4-ethoxy group is important for the αglucosidase enzyme inhibitory activity of the derivatives. Compound 2 with m-chloro benzaldehyde substitution recorded the highest inhibition among the tested compounds. The enzyme kinetic study also revealed that the most active compound 2 competitively inhibits the α-glucosidase enzyme. Furthermore, the docking study also demonstrated that the most active compounds 2, 6, 7 and 8 have various interactions with the residues in the receptors active site. The interactions that played a major role in the binding include hydrogen bonds, p-anion interactions and hydrophobic interaction. Keywords: CS Chem Office, Pyrimidine derivatives, hydrophobic interaction, Medicine. DESIGN, SYNTHESIS AND BIOLOGICAL ACTIVITY OF NEW SUBSTITUTED PYRIMIDINE DERIVATIVE AS -GLUCOSIDASE INHIBITORY ACTIVITY ICLTIPB/PH/2023/1004 1 2 Anamika Singh , Garima Carpenter 1 Parul Institute of Pharmacy and Research, Vadodara, Gujarat 2 Institute of Pharmacy , Vikram University, Ujjain Abstract: [email protected] One of the most effective methods for resolving issues with medication bioavailability is the use of novel drug delivery systems (NDDS). It refers to how quickly and how much a medicine is made accessible to the target tissue following injection. Over the past century, phytochemical science and phytopharmacological science have identified a number of plant compounds with a variety of biological activities and health-promoting benefits, such as anti-mutagenicity, anticarcinogenicity, and anti-oxidative activity, for age-related diseases like memory loss, osteoporosis, diabetic wounds, immune and liver disorders, etc. In this review poster, we focused on the development and characterization of phytosomes. Phytosomes are a novel drug delivery system approach that is effective at distributing the herbal drug at a predetermined rate, distributing the drug at the site of action, reducing toxic effects, increasing drug bioavailability, and regulating the distribution of the drug by incorporating the drug into the carrier system or changing the drug structure at the molecular level. The bilayer vesicles are adaptable and simple to prepare, which has led to their widespread usage and endorsement in the scientific literature. The first section of the poster focuses on presenting phytosome technology and its applications, with an emphasis on formulation and characterization concepts. Our final section summarises the promising clinical and experimental results of phytosome applications. The findings of this study promote future research into these items by urging scientists to take their discoveries from the lab to the marketplace. The combination of phytochemicals and phospholipids in phytosomes, a type of vesicular drug carrier, increases the bioavailability and absorption of bioactive compounds while also making the substance as a whole more stable. Keywords: Phytochemical, characterization, phytosome, delivery, vesicle, disease. A REVIEW OF THE OPTIMIZATION AND CHARACTERIZATION OF PHYTOSOME ICLTIPB/PH/2023/1003 1* 1 Jyotsana Dwivedi , Pranjal Sachan 1 Department of Pharmacy, Pranveer Singh Institute of Technology, Kanpur, India [email protected] Abstract: Antibiotic resistance of pathogenic bacteria is a serious problem in human and animal medicine and requires the development of new therapeutic and antibacterial strategies. Several plant compounds, such as Usnic acid, have potential as a new class of antimicrobial agents because they are effective against a variety of gram-positive and gram-negative bacteria, especially target cell membranes. As per Lancet around 1.27 million deaths were the direct result of AMR IN 2019. The rapid increase in microbial infectious diseases has been one of the most potential threats to human health and the cause of distressing millions of people around the world. Graphene is taken as carrier for Usnic acid nanoparticles. Graphene is 2D material made up of carbon atoms and Usnic acid as a drug though both are having fungicidal activity. In current research work, Usnic acid loaded NPs were conjugated with Graphene. Obtained nano-conjugate was further dispersed in to the ointment base which was made of PEG-400, PEG-4000, Glycerin and SLS. Optimized formulation was evaluated for chemically i.e. in vitro dissolution, in vitro and in vivo antimicrobial activity. In vitro dissolution of the Usnic acid was found to be controlled because of the hindrance from the ointment base however in vivo fungal activity was found to be significantly encouraging in comparison to the marketed product available with Clotrimazole with steroid, which shows that there is synergistic effect when both carrier and drugs are being used together even without steroid. Optimized formulation has shown significant in vivo antimicrobial activity. Combination therapy is the next generation tool where carrier or other excipients also having antibacterial activity is the future of the Medicine to eradicate AMRs – Superbugs. Keywords: Antibiotics, nanoparticles, Usnic acid, Combination therapy. A COMBINATION THERAPY FOR ANTI-MICROBIAL RESISTANCE IN SKIN INFECTION ICLTIPB/PH/2023/1005 Pradeep Kumar Vishwakarma Faculty of Pharmacy, Dr. A.P.J. Abdul Kalam University, Indore, India [email protected]

39 Souvenir Souvenir 40 Abstract: Leptin levels are strongly correlated with higher adiposity and exert sexual dimorphism, in females having more concentrations. Since, the results are influenced by ethnicity, race, dietary, and environmental factors, the study aimed to evaluate circulating leptin levels in different BMI among males and females in a population of Manipur. This cross-sectional study was conducted in the Department of Physiology, Regional Institute of Medical Sciences, Imphal, and enrolled 600 subjects (either sex) aged 20-65 years. After obtaining the consent of participants without a known history of chronic metabolic disorders and women not under the lactation period, blood samples were collected for the estimation of serum levels of leptin. The study population was categorized as non-obese (BMI<25 kg/m2) and obese (BMI ≥ 25 kg/m2). Data were presented as mean and standard deviation by calculating significance using Student's t-test and for correlations, Pearson's coefficient was used. Significance was p<0.05. This study showed significant differences in leptin levels between non-obese and obese (P<0.1). In sex dimorphism, females have found more circulating leptin concentration than males in each different BMI and it is statistically significant (P<0.1). The finding is consistent with the previous results that female has more susceptibility to increase leptin levels as adiposity is greater in female, but the magnitude of the rising leptin concentration is less, which may be due to genetic variance and food habits. Further, leptin level was positively correlated significantly with BMI (P<0.1). In this study, female groups have shown higher leptin concentrations than the male groups. We conclude that more adiposity higher leptin concentration. Keywords: Leptin, BMI, Sex Dimorphism, adiposity. SEX DIMORPHISM IN CIRCULATING LEPTIN CONCENTRATIONS IN RELATION TO BMI ICLTIPB/PH/2023/1006 Dr. Loushambam Samananda Singh Institute of Pharmacy, Assam Don Bosco University, Tapesia, Assam [email protected] Abstract: The advent of modern biotechnology furnishes a new track of breeding vegetable crops. The term biotechnology defined as a group of technologies that employ biological entities or processes to create new and useful products and processes. It is being used to address problems in areas of vegetable production and processing. Plant biotechnology has not only increased the scale of attributes that can be addressed but also accelerated the vegetable growing program. Vegetables thus play vital role in ensuring good health as it is rich source of vitamins, minerals, antioxidants and dietary fibres. Plant biotechnology has been used to raise and stabilize yields of vegetables; to improve resistance to pests, diseases and abiotic stresses such as drought and cold; and to enhance the nutritional content of foods. In this paper, we describe recent approaches, applications, advantages, and problems faced during the application of modern biotechnology in vegetable breeding research. Plant biotechnology has successfully revolutionised the field of biology and molecular breeding, which is accompanied by enhanced productivity and quality of vegetable crops. Keywords:biotechnology, vegetables, nutritional, quality. USE OF BIOTECHNOLOGICAL APPROACHES TO ENHANCE PROPERTIES OF VEGETABLE CROPS ICLTIPB/PH/2023/1007 1 2 Nivedita Gupta and Poonam Burman Faculty of Agriculture, Baba Farid College, Bathinda, Punjab [email protected] Abstract: Eggplant cultivation is of great importance as it provides economic, nutritional and health benefits to millions of people universally in the recent years. Its production is however hindered by various insect pests' infestations causing substantial damages and fruit yield penalty in the crop. The control of whiteflies depends heavily on synthetic chemicals which are associated with some adverse effects on human health and environment. This study aims to assess the potential of cow-based bio pesticides (cow dung, cow urine and butter milk) in whitefly control on eggplant using standard experimental settings. The result shows that cow urine (750 ml/l) is the most effective with 15.4 flies/leaf while cow dung (150 ml/l) is the least effective with 32.9 flies/leaf 15 days after the 1st spray as compared to the control (35.6 flies/leaf). Cow urine (750 ml/l) remained the most effective (5.4 and 2.0 flies/leaf) with butter milk (50ml /l) being the least effective recording 15.8 and 8.6 flies/leaf as compared to the control (24.2 and 21.9 flies /leaf) on the 1st and 15th days after the 2nd spray. The least whitefly number (1.1 flies/leaf) was recorded in cow urine on the 7th while the highest (12.9 flies/leaf) was recorded in butter milk (50 ml/l) on the 2nd day of the 3rd spray as related to the control (29.8 flies/leaf). The highest percentage reduction (94.63%) was found in cow urine (750 ml/l) on the 7th of the 3rd spray while the least reduction (0.67%) was recorded in butter milk (50 ml/l) 2 days after the 1st spray. The results demonstrate the bio pesticidal potential of cow-based products in whitefly management. More researches incorporating such products in insects' control are thus recommended as they are safe, sustainable and cost effective measures in whitefly control. Keywords: Biopesticides, eggplant, Bemicia tabaci, cow urine, whitefly population, management. FIELD EVALUATION OF THE POTENTIAL OF COW BASED PRODUCTS IN THE MANAGEMENT OF WHITEFLY (BEMICIA TABACI G.) POPULATION ON EGGPLANT (SOLANUM MELONGENA L.) ICLTIPB/PH/2023/1008 a b c Mustapha Abubakar , Bhupendra Koul , Ankush Raut a Department of Plant Science and Biotechnology, Kebbi State University of Science and Technology, Aliero, PMB-1144, Nigeria. b Department of Biotechnology, Lovely Professional University, Phagwara-144411, Punjab, India. c Department of Entomology, Lovely Professional University, Phagwara-144411, Punjab, India. [email protected] Abstract: There is a plenty of scientific evidence to support the use of Nyctanthes arbor tristis for medicinal purpose. However, some traditional healers claim that the leaves have antiinflammatory properties and can be used to treat conditions like arthritis and gout. There is enough clinical evidence to support these claims, and more research is needed. Nyctanthes arbor tristis is a plant that has traditionally been used in Ayurvedic medicine for its antiinflammatory effects. In a recent study, the leaves of this plant were shown to contain a number of compounds with anti-inflammatory activity. The most active compound was found to be lupeol, which was shown to inhibit the production of pro-inflammatory cytokines. This suggests that Nyctanthes arbor tristis may be effective in treating inflammatory conditions such as arthritis and inflammation. Keywords: Nyctanthes, inflammatory, healers, arthritis, traditionally, lupeol ANTI-INFLAMMATORY NATURE OF NYCTANTHES ARBOR TRISTIS ICLTIPB/PH/2023/1009 Ankit Shukla Career Point School of Pharmacy, Career Point University, Kota, Rajasthan. [email protected]

41 Souvenir Souvenir 42 Abstract: The present study was designed to evaluate the effect of Lavandula stoechas flower extract on Isoprenaline induced myocardial necrosis in experimental rats. The rats were divided into 5 groups and each group contained 5 rats. For 13 days, group I received 1 ml/kg, p.o. normal saline, group II rats received 10 ml/kg, p.o. normal saline, group III received extract (200 mg/kg body weight, p.o.) and group IV received extract (400 mg/kg body weight, p.o.) and group V received Metoprolol (10 mg/kg, p.o.). On days 14th and 15th group I additionally received normal saline (0.5 ml/kg, s.c.) and group II to V received Isoprenaline (85 mg/kg body weight, s.c.). On day 16th after treatment, the rats were weighed and blood was collected through cardiac puncture using thiopental sodium and serum was separated for the estimation of total protein, triglyceride and cardiac marker enzymes. After that rats were sacrificed, the heart was cut out for grading and histological investigations. The levels of marker enzymes (AST, ALT, LDH, and CK-NAC) in serum were significantly decreased (p < 0.01), the levels of total protein and triglyceride in serum were significantly decreased (p < 0.01) and the ratio of heart weight and body weight was significantly decreased (p < 0.05) in rats treated with Lavandula stoechas. Histopathology of heart tissue also showed protective effect of Lavandula stoechas. The study concluded that the flower extract of Lavandula stoechas possessed a protective effect against Isoprenaline induced myocardial infarction in rats. Keywords: Lavandula stoechas, normal saline, marker enzymes, isoprenaline. CARDIOPROTECTIVE EFFECTS OF LAVANDULA STOECHAS IN ISOPRENALINE INDUCED MYOCARDIAL NECROSIS IN RATS ICLTIPB/PH/2023/10010 Mohd Aftab Siddiqui*, Hefazat Hussain Siddiqui, Badruddeen, Mohd. Khalid Faculty of Pharmacy, Integral University, Dasauli, Kursi Road, Lucknow (U.P.)-226026 [email protected] Abstract: Since the beginning of pharmaceutical research, drug delivery methods have been an important part of it. Polymeric micelles (PMs) have come out as multifunctional nanoparticles in the current technological stage of nanocarriers, and they shown promise in a range of scientific fields. They can made difference the release profile of integrated pharmacological substances and concentrate them in the target zone due to their improved permeability and retention. By this perameter its make them more suitable for poorly soluble medicines. With their ability to deliver poorly soluble chemotherapeutic drugs, polimer have garnered considerable interest in cancer. As a result of their marvellous biocompatibility, improved permeability, and minimal toxicity to healthy cells. while also their capacity to solubilizing a wide range of drugs in their micellar core, PMs are expected to be a successful treatment option for cancer therapy in the future. Their nano-size enables them to accumulate in the tumor microenvironment (TME) via the enhanced permeability and retention (EPR) effect. In this topic our major aim is to focus primarily on the stellar applications of PMs in the field of cancer therapeutics along with its mechanism of action and its latest advancements in drug and gene delivery (DNA/siRNA) for cancer, using various therapeutic strategies such as crossing blood–brain barrier, gene therapy, photothermal therapy (PTT), and immunotherapy. Keywords: Target drug delivery, Polymeric micelles, Cancer therapy, Permeability. TUMOR-TARGETED DRUG DELIVERY SYSTEM ICLTIPB/PH/2023/10011 Anjali soni *, Dharmendra Solanki, Priyanka Yadav Lakshmi Narain College of Pharmacy Indore MP, India 453555 [email protected] Abstract: Immunotherapy is taking more attention than other treatment, especially in cancer treatment it is strongly expected to develop in the future. In this therapy Immune checkpoint inhibitors were developed as drugs with a completely different mechanism from conventional chemotherapy for cancer patients, and this immunotherapy the therapeutic effects were specified not only by tumor shrinkage but also by long-term surviving cancer patients, immunotherapy give a strong impact on cancer treatment. On the other hand, as a result of various clinical trials, it was found that the efficacy of immune checkpoint inhibitors alone is only about 15–30%. Presently, more than 3,500 clinical trials of combined cancer immunotherapy with immune checkpoint inhibitors, they being conducted with the hope of further improving therapeutic efficacy. And other new cancer immunotherapy is Chimeric Antigen Receptor (CAR) gene transfer T-cell therapy, it has been approved for B-cell hematopoietic tumors. In this information, we will outline the future prospects of cancer immunotherapy developed in this way, immunotherapy will give a good effect on cancer treatment and other deasease also, especially from the viewpoint of” strategies for ineffective cancer”. Keyword: Cancer Immunity Cycle Combined Cancer Immunotherapy, Immune Checkpoint Inhibitors, Therapeutic Efficacy. FUTURE PROSPECTS FOR CANCER IMMUNOTHERAPY ICLTIPB/PH/2023/10012 Priyanka Yadav, Dharmendra Solanki, Anjali soni Lakshmi Narain College of Pharmacy Indore MP, India 453555 [email protected] Abstract: The modified release product surrounded the dosage form design includes enteric coated tablets (including immediate release), and sustended-release products where drug release is controlled by the dosage form to place over a period of hours. Concept of targeted delivery is designed for set out to concentrate the drug in the tissue and reducing the concentration in the remaining tissue of the body. By using the polymer or by coupling the drug in the carrier such as microspheres, nanoparticles, liposomes, niosomes, pharmacosomes, aquasomes etc. which regulate the release and absorption characteristics of the drug. Microspheres are characteristically free flowing powders consist of drug and polymers having a particle size ranging from 1-1000 μm. In future by using various technology and strategies in microsphere that find the special place in novel drug delivery. Keywords: Targeted delivery, Microspheres, novel drug delivery. MICROSPHERES AS A NOVEL DRUG DELIVERY SYSTEM ICLTIPB/PH/2023/10013 Ankit kulpare, Dharmendra Solanki, Muskan Jain, Nancy Jain Lakshmi Narain College of Pharmacy Indore MP, India 453555 [email protected]

43 Souvenir Souvenir 44 Abstract: Cancer is one of the most lethal diseases that affects humans. Gold nanoparticles represent one of the most studied classes of nonmaterial for biomedical applications, especially in the field of cancer research. In fact, due to their unique properties and high versatility, they can be exploited under all aspects connected to cancer management, from early detection to diagnosis and treatment. Colloidal gold has been studied for its potential application in medicine for centuries. However, synthesis and evaluation of various gold nanoparticles have only recently been met with a wide interest of scientists. Current studies confirm numerous advantages of nanogold over different nanomaterials, primarily due to highly optimized protocols for the production of gold nanoparticles of countless sizes and shapes, featured with unique properties. The possibility to modify the surface of nanogold particles with different targeting and functional compounds significantly broadens the range of their potential biomedical applications, with particular emphasis on cancer treatment. Functionalized gold nanoparticles exhibit good biocompatibility and controllable biodistribution patterns, which make them particularly fine candidates for the basis of innovative therapies. Considering the high amount of scientific data on nanogold, this review summarizes recent advances in the field of medical application of gold nanoparticles for the therapy of cancer. Keywords: Cancer treatment, Gold Nanoparticles, Cancer Therapy, Nanotechnology, Detection, Diagnosis. GOLD NANOPARTICLES IN CANCER: -TREATMENT, DIAGNOSIS AND DETECTION ICLTIPB/PH/2023/10014 Amreen Qureshi*, Dharmendra Solanki, Ritu Jaiswal Lakshmi Narain College of Pharmacy, Indore MP, India 453555 [email protected] Abstract: Disintegration is the most important step for releasing the drug from the tablet matrix to decrease the disintegration time.In this, drug and polymers come in contact with water, it swells, hydrate, and react chemically to release the drug in the mouth and gastrointestinal tract.Superdisintegrantsare those substances that encourage the quick breaking down with a lesser amount contrasted with disintegrates. Disintegrants are substances or mixture of substances added to the drug formulations, which facilitate dispersion or breakup of tablets and contents of capsules into smaller particles for quick Mechanisms for tablet disintegration are swelling, dissolution, porosity and capillary action (wicking), deformation, enzymatic reaction, due to disintegrating particle/particle repulsive forces,heat of wetting, due to release of gases and combination action.Natural superdisintegrants have been used for fastdissolving tablets because they are biodegradable, chemically inert, n o n h a r m f u l , m o r e a ffo r d a b l e , a n d g e n e r a l l y accessible.Natural super disintegrants decrease the release time and give healthful results to the patients. Most polymers are obtained from nature; they are cost-effective, nontoxic, and nonirritants. Natural superdisintegrants includes mucilage of isapghula husk, cress, gum karaya, fenugreek seed and gum of locust bean, chitin and chitosan, gellan, agar, alginates, soy polysaccharide, Cassia fistula, xanthan, Cucurbita maxima pulp powder, Hibiscus rosasinensis Linn. Mucilage and mango peel pectin. Keywords: Disintegration, Natural, Superdisintegrants, polymers, Mucilage. NATURAL SUPERDISINTEGRANTS– NOVEL CONCEPT IN ORAL DRUG DELIVERY ICLTIPB/PH/2023/10015 Dharmendra Solanki*, Anjali soni, Priyanka Yadav, Ritu Jaiswal Lakshmi Narain College of Pharmacy Indore MP, India 453555 [email protected] Abstract: Effective targeted drug delivery systems have been a vision for a long time, but it has been mostly distracted by the complex chemistry that is involved in the development of new systems. The invention of nanosponges has become a significant step toward overcoming these problems. Nanosponges are small sponges with a size of about a microns, which can be filled with a various variety of drugs. These fine sponges can flow around the body until they dilivered the specific target site and stick on the surface and begin to release the drug in a controlled and predictable system. Because the drug can be released at the specific target site instead of circulating around the body it will be useful for a particular given dosage. Another important factor of these sponges is their aqueous solubility, so this allows the use of these systems for drugs with less solubility. Keyword: Target drug delivery, sponges , Aqueous solubility, Control drug release. NANOSPONGES- A REVIEW ICLTIPB/PH/2023/10016 Muskan Jain, Dharmendra Solanki, Ankit Kalpure, Naincy Jain Lakshmi Narain College of Pharmacy Indore MP, India 453555324005, India. [email protected] Abstract: Moringa is one of the important crop originated from india and Africa which can be exploited for its nutritive richness present in leaves, flowers and pods. The crop is suitable for cultivation in arid and semi - arid regions of india and tamilnadu. Recently the crop is re-discoverd for its potentiality in alleviating malnutrition which is the severe problem among young children and women throughout the world. Apart from its leaves, the flowers and pods are also useful in preventing many diseases and widely used in homeopathy, sidhha and ayurvedic preparation. Moringa tree can be grown in social forestry ecosystem, there by the livelihood, socioeconomic status of rural people may be improved. Moringa leaves when fed to cattle increase the milk yield and quality. India is one of the highly populated country and economic growth is surged ahead since independence but the nutritional security of the rural women and children is the biggest threatening issue to be addressed. This article aims at gathering information about moringa particularly its nutritional value and research carried out in moringa for further exploitation. Keywords: Malnutrition, Moringa leaves, Health drink, rural women and children. MORINGA LEAVES HEALTH DRINK FOR MALNUTRITION IN CHILDREN ICLTIPB/PH/2023/10017 Naincy Jain*, Dharmendra Solanki, Muskan jain, Ankit Kalpure Lakshmi Narain College of Pharmacy Indore MP, India 453555 [email protected]

45 Souvenir Souvenir 46 Abstract: PCOS is one of the common endocrine disordersamong women of reproductive age. Due to this problem of lack of ovulation, women with PCOS problem also suffer from major problem of infertility. Because of this imbalance in hormones, women have irregular menstrual periods. The two hormones namely, estrogene and progesterone, responsible for woman's ovaries to release eggs, are at lower level than normal level and then they lack follicle maturation. This syndrome leads to infertility, insulin resistance, obesity, and cardiovascular problems, including a litany of other health issues. PCOS is a polygenic, polyfactorial, systemic, inflammatory, dysregulated steroid state, autoimmune disease, manifesting largely due to lifestyle errors. The advent of biochemical tests and ultrasound scanning has enabled the detection of PCOS in the affected females. Subsequently, a huge amount of insight on PCOS has been garnered in recent times. Inter ventions like oral contraceptive pills, metformin, and hormone therapy have been developed to bypass or reverse the ill effects of PCOS. However, lifestyle correction to prevent aberrant immune activation and to minimize the exposure to inflammatory agents, appears to be the sustainable therapy of PCOS. This holistic review with multiple hypotheses might facilitate to devise better PCOS management approaches. Keywords: Endocrine disorder; Hormonetherapy; Inflammation; Women; Polycystic ovary syndrome (PCOS); Infertility; Irregular menstrual periods. DETECTION, TREATMENT AND HORMONALTHERAPY: - FOR INFERTILITY DUE TO PCOS ICLTIPB/PH/2023/10018 Ritu Jaiswal, Dharmendra Solanki, Amreen Qureshi Lakshmi Narain College of Pharmacy, Indore MP India 453555 [email protected] Abstract: Transdermal Drug Delivery Systems are defined as dosage forms in which the drug transport occurs via epidermal and/or dermal tissues of skin. This helps in the generation of local systemic effect. Most of the drug transport occurs into the systemic blood circulation. This transdermal drug delivery is advantageous for the patients who are unable to ingest orally. Drug delivery through transdermal route is one of the divisions of controlled drug delivery in which the objective is to deliver the drug through skin in a predetermined and controlled rate. Various types of TDDS are : adhesive dispersion type, membrane permeation controlled, microreservoir system and vapour patch. The matrix dispersion type patch was designed using polyethylene backing membrane method. Polymers of choice HPMC and Eudragit in different ratios were dispersed in the solvent system comprising Dicholromethane and Methanol in 1:1 ratio. Permeation enhancer and Plasticizer was added to this mixture. Drug particles was made added to this form a medicated polymeric dispersion. It was then casted into a compartment supported with polymeric backing membrane and adhesive was applied on the circumference of patch and release liner was also applied. The transdermal patch was evaluated for folding endurance, drug content analysis, stability test, drug release study, drug permeation study and irritation study. In total 9 formulations were formulated with appropriate marking and evaluated accordingly. Formulation with code F1 and F5 was found to better in stability and showed good release drug study as well as a good permeation rate. This was due to the increase in the quantity of hydrophilic polymer HPMC which enhanced the characteristics of a transdermal patch. Keywords:Transdermal Patch, Metoprolol Succinate, HPMC, Eudragit, Methanol, Dicholromethane. FORMULATION AND CHARACTERIZATION OF MATRIX DISPERSION TYPE TRANSDERMAL PATCH OF METOPROLOL SUCCINATE ICLTIPB/PH/2023/10019 Prachesh Pandey Department of Pharmacy, University of Kota, Kota, M.B.S Road, Near Kabir Circle, Kota (Rajasthan)-324005, India. [email protected] Abstract: The current study assessed the effect of Antineoplasticloaded transdermal patch in Dimethylbenzaanthracene (DMBA)-induced breast cancer. Different formulations composed of various concentrations of tamoxifen citrate, poly (SA: RA), glucose, mannitol were formulated and were evaluated in DMBA induced breast cancer in female albino Wistar rats. Multiple parameters such as body weight, hemoglobin content, red blood cell, white blood cell, SGPT, and SGOT were evaluated. Treatment with formulations showed a decrease in body weight contrast to disease. Equally, a considerable increase in hemoglobin was observed in the formulation treated group over disease grouping. Likewise, there decrease in SGPT and SGOT in formulation compared to disease. The present study revealed a transdermal patch loaded with tamoxifen showed promising antitumor activity. Keywords: Antineoplastic, nanoformulation, tamoxifen, transdermal patch TRANSDERMAL EFFECT OF TAMOXIFEN CITRATE ON INDUCED BREAST CANCER ICLTIPB/PH/2023/10020 Chandra Shekhar Sharma Teerthanker Mahaveer College of Pharmacy, TMU Moradabad-244001 [email protected] Abstract: Since the discovery of liposomes, drug delivery technology has advanced significantly in the realm of medicine. In the past 30 years, liposomes, which are tiny phospholipid bubbles with a bilayered membrane structure, have drawn a lot of attention as pharmaceutical carriers with enormous potential. They are an essential nano-sized drug delivery system with favourable features. They are typically between 50 and 1000 nm in diameter and act as an easy means of transport for drugs with therapeutic activity. There are now a rising number of liposomal-based medicines that have received FDA approval in addition to an increasing number that are undergoing clinical studies. These treatments cover a wide variety of uses in anticancer, antibacterial, and antiviral therapies. Because of their versatility as a drug delivery method and their biocompatibility, effectiveness, targeting capacity, and increased in vivo performance, liposomes have gained popularity. The possible uses of liposomal drug delivery include controlled and prolonged drug release, decreased systemic toxicity, and better pharmacokinetic and pharmacodynamic features of drugs. A technique that is more repeatable and has a wider a p p l i c a ti o n t o c u tti n g - e d g e tr e a t m e n t s l i k e immunotherapies, CRISPR/Cas9 therapies, and nucleic acid therapies. The combination use of diagnostics and treatments has been the focus of liposomal technology recently. The excipients of liposomal formulations utilized in numerous novel research, the preparation methods for liposomes employed most recently, and the routes of administration used to deliver liposomes to specific disease. It covers upcoming nanotechnological methods and tries to update the liposomal delivery research. Keywords: Liposomes, Phospholipid bubble, Bilayered, CRISPR/cas9 therapies. LIPOSOMAL DRUG DELIVERY SYSTEM: NEWER APPROACHES ICLTIPB/PH/2023/10021 Beena Rathore, Varsha Yadav, Dr. Meenakshi Bharkatiya 'Bhupal Nobles' Institute of Pharmaceutical Sciences B.N. University, Udaipur (RAJ)-313002 [email protected]

47 Souvenir Souvenir 48 Abstract: Up to 10% of people worldwide are affected by the chronic condition known as peptic ulcer. Peptic ulcer development is influenced by the pH of gastric juice and a decline in mucosal defenses. Proton-pump inhibitors, histamine (H2) receptor antagonists, prostaglandin analogues, and sucralfate have all been used to treat peptic ulcer disease. There has been a continuing search for an appropriate, palliative, and curative agent for the treatment of peptic ulcer disease using natural materials of plant and animal origin due to the complexity, cost, and toxicity of these medications. The goal of this review was to examine medicinal plants, phytochemicals, pathways, and research models that have been applied to the treatment of PUD in order to assess the potential contribution of natural substances to the development of herbal treatments for PUD. A literature search was used to find information utilising electronic databases such Web of Science, Google Scholar, PubMed, Sci Finder, Reaxys, and Cochrane. Keywords:Peptic ulcer, medicinal plants, pathways, models, treatment, toxicity. A COMPREHENSIVE REVIEW ON PEPTIC ULCER ICLTIPB/PH/2023/10022 Rishabh Gaur, Devender Pathak, Mayank Kulshreshtha Department of Pharmacy, Rajiv Academy for Pharmacy, Mathura (U.P.), India. [email protected] Abstract: Huntington's Disease is a degenerative brain disorder with irritable behavior, emotional trauma, cognition, etc. it is also known as Huntington's cholera. Female is more prone to Huntington's disease compared to males (20/100000 female and 11/100000 males). In India, the prevalence of the disease is different to estimate although in the European population 3 to 5 % / 100000 is affected. This review completely pathophysiological status, different molecular pathways, and pharmacological and non-pharmacological treatment of Huntington's disease. The scientific data were collected from google, PubMed, Scopus, Bentham, Elsevier, and other important online resources. This review paper may work as a backbone for upcoming new researchers, especially work on Huntington's disease. Keywords:Huntington's disease, Cholera, Antidopaminergic Agents, Antipsychotic Agents, Omega- 3 Fatty Acids, NMethyl-D-Aspartic Acid Receptor Antagonists. PATHOPHYSIOLOGICAL STATUS, MOLECULAR PATHWAYS AND TREATMENT UPDATES ON HUNTINGTON'S DISEASE ICLTIPB/PH/2023/10023 Kunal Suryavanshi, Devender Pathak, Shivendra Kumar, Mayank Kulshreshtha Rajiv Academy for Pharmacy, Mathura, India. [email protected] Abstract: Malaria is the most prevalent disease of the haematological system and is brought on by parasite infection. Malaria is a disease that can be fatal and is caused by an abundance of the malaria parasite referred to as Plasmodium (P) vivax, P. falciparum, and P. ovale. It is spread by the female anopheles mosquito biting a person. WHO estimates that India accounts for 3% of the world's malaria cases. Medical plants have recently developed a secure and accessible solution for the treatment of malaria. The purpose of this survey is to assess the potential value of using herbal natural components to create cures for malaria by examining the research of herbal plants, families, and their metabolites. A variety of sources, including Web of Science, Google Scholar, PubMed, Bentham Science, Elsevier, Springer, Nature, Wolters Kluwer, etc., were used to gather the data. Following the identification of 300 plants from 90 Families, data on the plant family, portion used, metabolite extract, model use, and parasites were abstracted. According to the findings, the Asteraceae, Fabaceae, and Rubiaceae families contained the majority of antimalarial plants. Alkaloids and flavonoids were the most active and prevalent natural plant metabolites with antimalarial action, and the leaves were the component of the plant that received the most scientific attention. Keywords: Malaria, herbal plants, Plasmodium vivax, Plasmodium falciparum, alkaloids, flavonoids, Asteraceae. A STUDY OF PLANTS USING MEDICINAL PROPERTIES TO TREAT MALARIA: A CLINICAL REVIEW ICLTIPB/PH/2023/10024 Harsh Jain, Devender Pathak, Mayank Kulshreshtha Rajiv Academy for Pharmacy, Mathura (U.P.), India. [email protected] Abstract: Acne is a frequent form of skin condition brought on by an overproduction of the particular oil “sebum”, which is produced by the sebaceous gland. This oil accumulates in the follicles and causes the swelling of pores. Sebum buildup in the follicular pores is a favourable environment for "Propionibacterium acnes," which will worsen the acne problem. Tea tree oil (TTO), which comes from the plant Melaleuca alternifolia (M.alternifolia), is a prominent ingredient in over-the-counter (OTC) acne treatments that are widely accessible today. TTO is a natural aromatherapy oils made from M. alternifolia leaves that is utilised in several anti- acne treatments. TTO contains more than 100 different chemical substances, including monoterpenes and sesquiterpenes that have been bonded to alcohol. Terpine4-ol, this oil's primary component, has antibacterial effects. This oil has a hydrophobic characteristic, that rendering it less soluble in water-based formulations. The usage of gels has grown over the past few decades as a result of their simple production processes and extended stability. Consequently, the goal of this experiment is to create a gel formulation that contains TTO as a local delivery approach for the cure of acne. Furthermore, the invitro release profile of gel was also performed. Keywords: Acne, OTC, Tea Tree oil, sebum, aromatherapy FORMULATION AND EVALUATION OF TEA TREE OIL GEL ICLTIPB/PH/2023/10025 Karan Agrawal, Mayank Kulshreshtha, Talever Singh, Vibha Rajiv Academy for Pharmacy, Mathura (U.P.), India. [email protected]

49 Souvenir Souvenir 50 Abstract: Medicinal plants are well known for treatment and management of different types of cancers. Muntingia calabura is one of the well-known medicinal plants reported for its anticancer effect. The objectives of the proposed research work are to computationally screen and identify the flavonoid fractions study its in-vitro anticancer activity against colon cancer cell lines. The bioactive flavonoids from Muntingia calabura were screened using computational tools like Schrodinger's software via Maestro 12.4 interface. The molecular docking of selected phytochemicals were carried out using Schrodinger's software against various targets of colorectal cancer. In-vitro study of fractions were carried out using colon cancer cell lines. The results of molecular docking studies showed good number of bioactive compounds have affinity against various targets of colorectal cancer. In-vitro anticancer profiling of plant fraction exerts good activity against cancer cell lines. 5-Furouracil was used as standard. The computational screening studies concludes that the screened phytochemicals prove to be potent drug candidates with good membrane permeability and bioavailability. The molecular docking studies showed good number of bioactive compounds have affinity against various targets of colorectal cancer and can be explored further for isolation and in-vitro, in vivo evaluation. Keywords: Bioflavonoids, Colorectal Cancer, Docking, 5- Flurouracil, Schrodinger. COMPUTER AIDED SCREENING AND IN-VITRO ANTICANCER ACTIVITY OF BIOFLAVONOID FRACTIONS OF MUNTINGIA CALABURA AGAINST COLO 205 CANCER CELL LINES ICLTIPB/PH/2023/10026 *1 1 Shailendra S. Suryawanshi , M. S. Palled *1,1Department of Pharmaceutical Chemistry, KLE College of Pharmacy Belagavi, KLE Academy of Higher Education and Research, Belagavi-560010, Karnataka, India. [email protected] Abstract: Cryptosporidiosis caused by Cryptosporidium spp. is a zoonotic disease and is the most prevalent pathogens worldwide and leads to severe diarrhoeal diseases and affects the immunological status of the individual. Thus, the study was undertaken to examine the anti-cryptosporidial efficacy of curcumin in comparison with ethanolic extract of curcuma longa in immunocompromised mice infected with oocysts isolated from cattle calves of Jammu region and identified as Cryptosporidium parvum using nested PCR on small subunit ribosomal ribonucleic acid (SSU rRNA) gene. Different working concentrations of ethanolic extract of C. longa was prepared in HPLC grade methanol. Two hundred female Swiss albino mice were equally divided into ten groups. Group I were kept as a healthy control, group II were immunocompromised, group III were immunocompromised and infected, group IV animals were immunocompromised, infected and treated orally with n it a z o x a n i d e . A n i m a l s i n g r o u p s V t o V I I w e r e immunocompromised, infected and treated with ethanolic extract of C. longa @ 4, 6 and 8 mg/kg/day/os respectively whereas groups VIII to X were immunocompromised, infected and treated with pure salt of curcumin @ 4, 6 and 8 mg/kg/day/os respectively for 5 successive days. Thus, mean oocysts per gram faeces and body weight gain were measured in different groups. Extractability percent of ethanolic extract of C. longa was recorded to be 6.4% in the present study whereas curcumin was considered as the major chemical, constituting 25% of the extract. Administration of curcumin as a therapeutic agent @ 8 mg/kg body weight for five days resulted in higher percent mean oocyst reduction of 74.03% and improved body weight gain in experimentally infected mice. Thus, the presence of other constituents in ethanolic extract of C. longa and therefore interactions among various constituents may be the cause of reduced efficacy of ethanolic extract of C. longa as compared to pure salt of curcumin. Altogether, curcumin showed promising anticryptosporidial effects under in vivo conditions and deserves further exploration. Keywords: zoonotic disease; curcumin; anticryptosporidial; mice. COMPARATIVE EFFICACY OF CURCUMIN, CURCUMA LONGA (TURMERIC) AND NITAZOXANIDE AGAINST CRYPTOSPORIDIUM PARVUM INFECTION IN MICE ICLTIPB/PH/2023/10027 Alveena Ganai, Anish Yadav, Rajesh Katoch, Dibyendu Chakraborty and Pawan Kumar Verma Department of Veterinary Parasitology, COVS, GADVASU, Ludhiana. [email protected] Abstract: Biodiversity is the difference between living beings and living organisms at any given place. Each place has different species of plants, animals, and other organisms present. Biodiversity gives us many resources like food, clothing, shelter, and the article will share more reasons why biodiversity is important to everyone. A Common Measure of this variety, called Species Richness, is the Count of species in an area. Colombia and Kenya, for example, each have more than 1,000 breeding species of birds, whereas the forests of Great Britain and of eastern North America are home to fewer than 200. Biodiversity is Important for human lives because: A human being is interdependent on nature for survival. The Best Ways to Conserve Biodiversity are Government legislation, Nature preserves, reducing invasive species, Habitat restoration, Captive breeding and seed banks, Research, Reduce climate change, Purchase sustainable products. The Goals of Biodiversity Conservation are to preserve different varieties of species present in the ecosystem, for proper flow of the food chain and food web, to maintain the proper mixture of air in the atmosphere, as release of oxygen, carbon dioxide and many more gases are totally dependent on the density of biodiversity etc. The primary goal of conservation is to protect natural resources, forests, wildlife, plants, and biodiversity. The Three Main Objectives of Biodiversity Conservation are to preserve the diversity of species, Sustainable utilization of species and ecosystem, to maintain life-supporting systems and essential ecological processes, maintenance of essential ecological processes and life-support systems, preservation of genetic diversity, sustainable utilization of species and ecosystems. Keywords:Biodiversity food, clothing, shelter. BIODIVERSITY & CONSERVATION OF MANAGEMENT ICLTIPB/PH/2023/10028 Vikram Pandey B.N. College of Pharmacy Lucknow (U.P.) [email protected] Abstract: Food technology is a branch of food science that deals with the production selection, preservation, processing, packaging, distribution, quality control, research and development of food products. Related fields include analytical chemistry, biotechnology, engineering, nutrition, quality control, and food safety management.This science is the applied science & basic science of food & scope starts with agricultural science and nutritional science and leads through the other scientific aspects of food safety and food processing, informing the development of food technology.Early scientific research into food technology concentrated on food preservation. Nicolas Appert's development in 1810 of the canning process was a decisive event.Some of the Developments of food technology areFreeze Drying , Aseptic Packaging etc.The Ways in different technology is changing our food are - GMO's , Drones , Food waste tracking in country etc .The Importance technology for manufacturers continues to grow. Food industry customers, like retailers, set stricter product requirements and require larger volumes at low prices. A system called WaterBee collects data on soil content and other environmental factors using wireless sensors to reduce water waste. As a deep dimensions of food technology, we are require professionals in this field. And, it has led to the emergence of food technology courses. Food processors take raw animal, vegetable, or marine materials and transform them into edible products through the application of labor, machinery, energy, and scientific knowledge. According to the FDA, Recently updated data there are approximately 44,000 food processors and 113,000 food warehouses in the U.S. that provide processed foods to our country, different exports throughout the world. The processors include canners, producers, wineries, and other food and beverage manufacturers and distributors. There are more than 1.2 million retail food facilities (restaurants, grocery stores, and others) that serve or sell foods directly to consumers. Keywords: Food technology, biotechnology, engineering. A REVIEW ON FOOD TECHNOLOGY ICLTIPB/PH/2023/10029 Ashi Patel, Ramesh Kr. Singh B.N. College of Pharmacy Lucknow (U. P.) [email protected]

51 Souvenir Souvenir 52 Abstract: Cardiotoxicity is a disease that develops during treatment with a variety of cytotoxic medications and may be a doselimiting element in the treatment of cancer, along with an unbalanced diet and way of life. In recent years, the usage of herbal supplements has grown in popularity. Myocardial infarction is regarded as one of the deadliest disorders of all cardio vascular diseases. Given that the disease is brought on by a variety of reasons and that the existing synthetic medications have side effects, the treatment might not be enough to cure the disease. Using electronic databases including web of science, google scholar, PubMed, and Sci finder, a literature search was done to find information. Eventually, 140 plants were found; chemical ingredient extracts were used for plant parts. the Fabiaceae family had the most potential to treat myocardial infraction, while flavonoids and alkaloids were the most prevalent naturally occurring compounds found in plants, according to the results. Keywords: Cardiotoxicity, flavonoids, myocardial infraction, alkaloids, Fabiaceae. A SURVEY ON THE USE OF MEDICINAL PLANTS IN THE TREATMENT OF MYOCARDIAL INFARCTION DISEASE ICLTIPB/PH/2023/10030 Anamika Rathore, Mayank Kulshreshtha Department of Pharmacology, Rajiv Academy for Pharmacy, Mathura (U.P.), India. [email protected] Abstract: For a long time, innate cells have been investigated as drug carriers. Due to advances in biology and medical research, they have recently attracted increased interest as a viable drug delivery system (DDS). Whether organic or inorganic, synthetic materials have been discovered to be immunogenic and cytotoxic. Cell membranes are a relatively new supply of materials for molecular delivery systems. Nanoscale vesicles have been created by extruding or sonicating cell membranes. Unlike synthetic lipid or polymeric nanoparticles, cell membranederived vesicles have a unique multi-component structure that includes lipids, proteins, and carbohydrates. Because cell membrane-derived vesicles retain their parent cells' fundamental functions and signaling networks, they can overcome various in-vivo challenges. Moreover, the different natural combinations of membranes from multiple cell sources expand the range of cell membrane-derived vesicles, creating an entirely new category of drug-delivery systems. Cell membranederived vesicles can transport therapeutic substances or cover the surfaces of drug-loaded core nanoparticles. Single-cell sources of cell membranes include red blood cells, platelets, immune cells, stem cells, and cancer cells. However, new research has revealed hybrid origins derived from two different types of cells. This review will cover methods for producing cell membrane-derived vesicles and treatment applications of various cell membrane-derived drug-delivery systems, as well as explore obstacles and research perspectives. Keywords: Cell Membrane, drug-loaded core nanoparticles, parent cells, therapeutic agents. CELL MEMBRANE-DERIVED VESICLES FOR THERAPEUTIC DRUG DELIVERY ICLTIPB/PH/2023/10031 Innocent Sutnga Institute of Pharmacy, Assam Don Bosco University, Tapesia, Sonapur, Assam-782402, India [email protected] Abstract: Quercetin is a naturally occurring flavonoid present in virtually all edible plants and fruits. The Western diet has a large amount of quercetin, about 15 mg per day. The bioavailability of quercetin, defined as the proportion of an originally given dosage that enters the systemic circulation unmodified is extremely low, owing mostly to its extensive metabolism. Flavonoids must first be released from plant tissue by chewing in the mouth cavity before being digested by digestive fluids in the intestine or microbes in the colon. The enterocytes absorb quercetin glycosides via two different pathways. Absorption occurs first by a transporter, followed by deglycosylation within the enterocyte by cytosolic glycosidase. Secondly, deglycosylation can occur by luminal hydrolases, followed by transport of the aglycone into enterocyte by passive diffusion or via different transporters. The bioactivities of the quercetin derivatives were comparable to those of the standard and onion. The antioxidant effectiveness of quercetin was reduced when its hydroxyl groups were derivatized. However, the quantity of free hydroxyl groups in quercetin did not correlate with its ability to prevent the generation of inflammatory mediators. quercetin's anti-inflammatory potential, particularly its ability to inhibit AA metabolism and the production of eicosanoids - potent inflammatory mediators. flavonoid anti-inflammatory and antioxidant properties are required for its function as an oxidative, kinase, and cell cycle inhibitor, as well as neuronal survival. The key to its anticancer potential is its ability to induce apoptosis. Que, like many other chemicals containing a flavone ring, has a significant impact on immunity and inflammation. To summarise, quercetin derivatives found in systemic circulation following quercetin ingestion may operate as powerful antioxidants and anti-inflammatory agents, contributing to the total biological activity of a quercetinrich diet. Keywords: Flavonoids, Quercetin, Anti-inflammatory, Antioxidant, Immunity, Eicosanoids. DERIVATIZATION OF FLAVANOID AND EVALUTION OF ANTI-INFLAMMATORY ACTIVITY ON EXPERIMENTAL ANIMALS ICLTIPB/PH/2023/10032 Kripa Shankar Singh* United Institute of Pharmacy, Naini, Prayagraj, Uttar Pradesh [email protected] Abstract: Nano-structured lipid carriers (NLCs) are colloidal particles with sizes ranging from 10 to 1000 nm. NLCs can deliver the drug in controlled manner and considered as a nano-safe carriers because they are produced with the help of biodegradable and physiological lipids. NLCs are second generation of lipid nanoparticles and it is a modified form developed to overcome the drawbacks associated with solid lipid nano-particles (considered as the first generation of lipid nano-particles with solid matrix). NLCs are developed by mixing solid and liquid lipids and are solid at room as well as body temperature. It is suitable for both hydrophilic and lipophilic drug with higher entrapment efficiency. The drug taken in this research work is well known for antifungal activity. Oral absorption of voriconazole is very high and can also be administered by i.v. route in serious cases but it shows various systemic side effects when patients undergo prolonged therapy. The skin penetration of voriconazole can be enhanced by the virtue of the small size and lipidic nature of nano structured lipid carrier that may help to cross the various lipid membrane barriers in our body. NLC also contains liquid lipid so it will improve the solubility and loading of drugs into the liquid lipid matrix. Thus, NLC of voriconazole could be promising in enhancing the efficacy of voriconazole. The topical administration of nanostructured lipid carrier allows maximum permeation, due to high affinity to lipid rich intercellular space of stratum corneum. Therefore, they enhance bioavailability. The lipid nanoparticles are considered safer option in comparison to other nano-systems as they are biodegradable and do not cause toxicity. In addition, double layer of lipid matrix (solid lipid and liquid lipid) allows sustained release of drug. Keywords: Nanostructured lipid carriers, Voriconazole, Antifungal activity, Solid lipid, Liquid lipid. DEVELOPMENT AND EVALUATION OF VORICONAZOLE LOADED NANOSTRUCTURED LIPID CARRIERS FOR TOPICAL MYCOSES ICLTIPB/PH/2023/10033 Akanksha Patel United institute of pharmacy, Naini Prayagraj [email protected]

53 Souvenir Souvenir 54 Abstract: Tuberculosis is regarded as the most pervasive public health risk. It is caused by highly pathogenic bacteria known as Mycobacterium tuberculosis, which typically attacks the lungs. Mycobacterium TB drug resistance is a serious impediment to allopathy therapy. As we have seen over the years, the medications suggested for the treatment of tuberculosis include isoniazid, rifampicin, pyrazinamide, ethambutol, and streptomycin as first-line treatments. Amikacin, Capreomycin, Kanamycin, Ethionamide, Cycloserine, p-aminosalicylic acid, Clofazimine, Bedaquiline, and Linezolid are among the second-line medicines. However, the use of allopathic medicines creates a problem of cross-resistance, which is associated with serious side effect s such as hepatiti s caused by i soniaz id, thrombocytopenia caused by Rifampicin, and so on. To overcome all such agitated and unwanted effects, traditional medicinal products play an important role in being the most effective drug candidates in this context. So, in order to successfully treat the unhealthy circumstances linked with TB, the remedies that appear to be the final necessity to date should be investigated. Thus, the numerous phytochemicals used to treat tuberculosis have been found to have a high potential for efficacy, improving natural immunity and negating the negative effects caused by the use of the aforementioned allopathic medications. This article will reveal info on plants whose active chemical moiety is responsible for TB therapy. In addition, the active chemical moiety's derivatives and the plant extract made using a specific solvent exhibit outstanding antitubercular action. Further molecular docking studies were conducted for the phytochemical derivatives, which ultimately demonstrated excellent biological activity and therapeutic efficacy. As a result, we anticipate that such traditional medicinal products will play a crucial role in the fight against tuberculosis in the future. Keywords: Tuberculosis, traditional medicinal products, chemical moiety, phytochemicals, molecular docking. CHEMISTRY OF TRADITIONAL MEDICINAL PRODUCTS USED AS A CRUCIAL SOURCE FOR THE DISCOVERY OF POTENTIAL ANTI-TUBERCULAR DRUGS ICLTIPB/PH/2023/10034 Akash Sharma, Bidyut Bikash Laskar, Deep Bose, Institute of pharmacy, Assam Don Bosco University, Kamrup (M) [email protected] Abstract: The medicinal herbs are used such as crude form in which numerous phytoconstituents are present. Traditional healer employs the Abelmoschus genus for a huge variety of disease in traditional medicine. Abelmoschus esculents also known as okra, belongs from malvaceae family. The ethnobotanical and reported studies say it is indicated hyperglycaemia and diabetes. In this study evaluation of relationship between various active constituents with targeted protein relating to diabetes in human. The molecular docking involved the docking of 3D structure of ligand to selected targeted protein. In this molecular docking study, confirmed that the selected phytoconstituents having good interaction to the specific targeted protein, among the selected active constituent, the 2 compound, viz. flavanol and quercitin-3-sporoside are having pronounced docking and interaction with receptor 1B2Y and 5NN8 the hyperglycemic activity. The molecular study is done by using the software Schrodinger v 13.1. In the molecular docking two receptor are targeted Alpha Amylase and Lysosomal Alpha Glucosidase which show antidiabetic effect with targeted ligand. Docking study reveals potent implication of Abelmoschus esculents in hyperglycaemia and diabetes. The Schrodinger v 13.1 QikProp module was used to estimate the ADME properties of the derivatives of Abelmoschus esculents. In this articcle shows the antidiabetic activity by Abelmoschus esculents active constituent by study molecular docking and ADME study. Keywords:phytoconstituents, Diabetes, docking, ADME. MOLECULAR DOCKING OF PHYTOCONSTITUENTS OF ABELMOSCHUS ESCULENTS FOR ANTIDIABETIC ACTIVITY ICLTIPB/PH/2023/10035 Varsha Yadav, Yash Nagar, Dr. Meenakshi Bharkatiya 'Bhupal Nobles' Institute of Pharmaceutical Sciences B.N. University, Udaipur (RAJ)-313002 [email protected] Abstract: Patents play a crucial role in the pharmaceutical industry, particularly in the area of research and development. A patent provides the holder with exclusive rights over their invention for a specified period of time, allowing them to prevent others from making, using, or selling the invention without their permission. In the pharmaceutical industry, patents can provide a valuable incentive for companies to invest in research and development. The high costs of developing new drugs make it imperative for companies to recoup their investment, and patents can provide a mechanism for doing so by allowing companies to maintain a competitive edge in the market and earn a return on their investment. Moreover, patents can also serve as a tool for protecting the significant investments made in the development of new drugs. By granting exclusivity over the drug, patents can prevent competitors from simply copying the invention and selling it at a lower price, thus undermining the investment made by the company. However, the use of patents in the pharmaceutical industry is not without its challenges. The high cost of drugs protected by patents can limit access to essential medicines for many individuals, particularly in developing countries. Additionally, the patent system can also be abused, with companies seeking to extend their monopolies through the use of ever greening and other tactics. In short, patents play a crucial role in the pharmaceutical industry, providing incentives for companies to invest in research and development and protecting their investments. However, a balanced approach to the use of patents is necessary to ensure that the benefits of new drugs are widely accessible, while also protecting the investments made in their development. Keywords:Patents, Invention, Research, new drugs. PATENTS IN PHARMACEUTICAL RESEARCH AND DEVELOPMENT ICLTIPB/PH/2023/10036 Sheela Suthar, Mohammad Azhar, Dr. Meenakshi Bharkatiya Bhupal Noble's Institute of Pharmaceutical Science, Bhupal Noble's University, Udaipur [email protected] Abstract: Regulatory Affairs and Intellectual Property Rights (IPR) play a crucial role in the pharmaceutical industry. Regulatory Affairs ensures that the development, manufacture, and marketing of pharmaceutical products comply with the relevant laws, regulations, and guidelines set by various governmental agencies. On the other hand, IPR provides legal protection for the inventions and innovations in the field, allowing companies to secure exclusivity over their products. This allows them to recoup the costs of research and development and maintain a competitive edge in the market. In the pharmaceutical industry, Regulatory Affairs is responsible for obtaining regulatory approval for new drugs, managing product registrations, and ensuring ongoing compliance with the regulations. This involves preparing and submitting applications, responding to regulatory agencies, and working with other departments within the company to ensure that the product is developed and manufactured in compliance with the relevant regulations. IPR, on the other hand, protects the unique aspects of a product, such as its composition, formulation, and manufacturing process. Patents, trademarks, and copyrights are the most commonly used forms of IPR in the pharmaceutical industry. Companies can use these forms of IPR to secure exclusivity over their products, allowing them to recoup the costs of research and development and maintain a competitive edge in the market. In conclusion, Regulatory Affairs and IPR play a crucial role in the pharmaceutical industry, as they ensure that products are developed, manufactured, and marketed in compliance with the relevant regulations and that companies are able to secure exclusivity over their products. Keywords: Intellectual Property rights; Regulatory affairs; Companies; regulations. IMPORTANCE OF REGULATORY AFFAIRS AND INTELLECTUAL PROPERTY RIGHTS (IPR) IN PHARMACEUTICAL INDUSTRY ICLTIPB/PH/2023/10037 Mohammad Azhar Bhupal Noble's University [email protected]

55 Souvenir Souvenir 56 Abstract: Hypertension is one of the common diseases affecting humans throughout the world. It is also known as high blood pressure or arterial hypertension, is a chronic medical condition in which the blood pressure in the arteries is persistently elevated. Blood pressure is expressed by two measurements, the systolic and diastolic pressures; those are the maximum and minimum pressures respectively in the arterial system. The systolic pressure occurs when the left ventricle is most contracted; the diastolic pressure occurs when the left ventricle is most relaxed prior to the next contraction. The definition of abnormally high blood pressure is extremely difficult and arbitrary. Thus, there is clearly need to develop effective strategies to improve management. Losartan Potassium was procured from E m b i o ti c L a b o r a t o ri e s L t d . , B e n g a l u r u a n d Hydrochlorothiazide was procured from Centurion Laboratories, Gujarat. ATR and DSC studies can be used to investigate any physicochemical interaction between components in a formulation; therefore, these studies were applied for the selection of suitable chemically compatible excipients. Here Ionotropic gelation method was employed for the preparation of losartan potassium-loaded microbeads. The IR spectrum of pure drug, polymers, and physical mixture of drug and polymer were studied. The peaks obtained in the spectra of optimized formulation were correlated with the peaks of the drug spectrum. This indicates that the drug was compatible with the formulation components. As described in the methodology compatibility studies were performed using an ATR spectrophotometer. The IR spectrum of pure drug, polymers, and physical mixture of drug and polymer were studied. The peaks obtained in the spectra of optimized formulation were correlated with the peaks of the drug spectrum. This indicates that the drug was compatible with the formulation components. The present study demonstrated the successful formulation and evaluation of a regioselective dual component capsule. The drug excipients compatibility studies were carried out using ATR and DSC. Spectra revealed that there was no interaction found between drugs and excipients used in the formulations. From the above study, it can be concluded that the prepared regioselective dual component capsule achieved the objective of the research work in treating hypertension with the sequential release of two drugs. Keywords: Hypertension, abnormally, microbeads, spectrophotometer. DESIGN AND EVALUATION OF LOSARTAN POTASSIUM SUSTAINED AND HYDROCHLOROTHIAZIDE IMMEDIATE RELEASE DRUG FORMULATION ICLTIPB/PH/2023/10038 Bimal Debbarma, Chandra Kishore Tyagi School of Pharmacy, Sri Satya Sai University of Technology and Medical Sciences, Sehore - 466002, Madhya Pradesh, India [email protected] Abstract: For the development of highly predictive 2D and 3D QSAR model for anti-inflammatory activity, a series of 21 molecules of thiazole derivatives reported in literature Ashok kumar et al (2010) were used. The data set of 21 molecules were divided into training and test set in the ratio of 70:30. For the development of QSAR models biological activities(pIC50) were converted into logarithmic form. The statistically significant 2D-QSAR MLR model giving r2 = 0.9670 and q2 =0.8681. 3D QSAR kNN method shows results for internal (q2 = 0.9078) and external (predictive r2 = 0.6020) on validation criteria. Thus, 3D QSAR models showed that electrostatic effects dominantly determine the binding affinities. 2D QSAR studies revealed that Xlog P descriptors were major contributing descriptor. Results derived may be useful in further designing novel thiazole derivatives with improved activities. Keywords:QSAR, MLR, kNN, XlogP, Thiazole. DEVELOPMENT OF HIGHLY PREDICTIVE QSAR MODELS BY USING KNN & MLR METHODS FOR ANTI-INFLAMMATORY ACTIVITY OF THIAZOLE DERIV ATIVES ICLTIPB/PH/2023/10039 Ruqaiya Jamal, Ziyaul Haque, Mohamad Taleuzzaman, Durga Choudhary Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Maulana Azad University, Jodhpur [email protected] Abstract: Formulation and evaluation of transdermal patch of Boswellia serrata plant extract i.e. acetyl keto boswellic acid. The use of herbal medicine has grown in importance on a global scale, both medically and economically. The current research involved the formulation & development of acetyl keto boswellic acid transdermal patch for the treatment of arthritis. The transdermal patch of boswellic acid was formulated by chitosan (Polymer) with the incorporation of propylene glycol as a permeation enhancer and glycerol as plasticizer. The transdermal patch of Acetyl keto boswellic acid was successfully prepared and produced a uniform, fl e x i b l e, a n d s m o o t h tr a n s d e r m a l p a t c h. T h e physicochemical study was done or carried out to identify the drug and its properties. The transdermal patch was evaluated for uniformity of thickness, weight variation, moisture loss, moisture content, moisture uptake, folding endurance and drug content. The moisture loss and moisture uptake data reflecting the patches will remain stable under both dry and humid conditions. The drug content study reviled that the process employed to prepare the transdermal patches was capable of affording uniform drug distribution within formulations and uniform drug content. The data obtained from in- vitro release (egg membrane method) shows the sustained and controlled release of drugs from the patch which will help to inhibit inflammatory regulators like TNF- , interleukins etc. Altogether, chitosanbased transdermal preparations can be considered a promising approach for the treatment of inflammatory diseases like arthritis. Keywords: Boswellia serrata, Anti-inflammatory, Arthritis, Transdermal Patch, Folding endurance. FORMULATION AND EVALUATION OF TRANSDERMAL PATCH OF ACETYL KETO BOSWELLIC ACID FOR TREATMENT OF ARTHRITIS ICLTIPB/PH/2023/10040 Sudhanshu Mishra, Deepti Jain Department of Pharmaceutical Science & Technology Madan Mohan Malaviya University of Technology, Gorakhpur School of Pharmaceutical Science, Rajiv Gandhi Technical University, Bhopal [email protected] Abstract: The objective of the present study was to formulate and evaluate fast dissolving solid oral formulations of Etodolac using solvent free technology. Etodolac, BCS class II drug, with t1/2 approx. 7 hrs and absolute oral bioavailability about 80-85%, indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis. In present study, solvent free technique is used in order to improve the dissolution and oral bioavailability of the model drug with poor solubility and high permeability. Solid oral formulations (F1 – F9) were prepared by direct compression technique using solvent free technology with Kyron t 314 and Musa paradisiaca L as a super disintegrants in different ratios and analyse the usefulness of DOE in the development and optimization of a tablet of a model drug employing 32 full factorial statistical design. The drug-polymer compatibility study was carried out to determine the interactions, if any between the drug and the polymers used in the study. The FTIR, XRD and DSC study revealed that, polymers and excipients used were compatible with drug. The prepared tablets were subjected to various evaluation such as hardness (2.90–3.60 kg/cm2), friability (0.58–0.70%), disintegration time (12–22 s), drug content (96.00–99.18%), water absorption ratio (28–48%), wetting time (60–100 s) and in-vitro drug release shown in 5 min (96.40–99.80%). 0 Optimized batch when subjected to stability at 40+2 C temperature with relative humidity 755% for six months, showed no degradation and change in tablet and showed rapid dissolution and effective in achieving patient compliance. Keywords: Etodolac, Solid oral tablet, Kyron t 314, Musa 2 paradisiaca L, FTIR, XRD, DSC, 3 Factorial Design. DESIGN & OPTIMIZATION OF FAST DISSOLVING SOLID ORAL FORMULATIONS 2 OF ETODOLAC USING SOLVENT FREE TECHNOLOGY BY 3 FACTORIAL DESIGN ICLTIPB/PH/2023/10041 Pravin K. Bhoyar, Revathi A. Gupta, Rajendra T. Bafna, Karunakar R. Shulka Faculty of Pharmacy, Dr. A.P.J. Abdul Kalam University, Indore – Dewas Bypass, Arandia, Indore -452010 (M.P.) [email protected]

57 Souvenir Souvenir 58 Abstract: Neurodegeneration is an irreversible pathological process. The probable causes of neuronal loss in Parkinson disease are deposition and misfolded of proteins inside the brain such as biomarkers alpha-synuclein which later on converts to the Lewy's bodies. In our present study we have chosen parts of plants which have neuroprotective as a good antioxidant activity. There are many medicines in allopathic system to manage Parkinsons disease. But they have their own side effects in our present study we will prepare a herbal formulation to treat Parkinson's disease with minimal or no side effects. Also, the herbal formulation will be very low cost. The study has been designed as “Pharmacological Assesssment of Herbal Suspension for Anti Parkinsons activity in rat”. Moringa Oleifera and Rosa canina are well known plants for their health benefits and medicinal value. A number of constituents have been isolated from the both plant extract that include ellagic acid gallic acid. Rosa canina contains high concentration of carotenoids. It possesses antimicrobial, cardiotonic, antioxidant, antiviral, antidiabetic, anticancer, activities. In our present study we have selected 5 groups in each group there are 8 animals. Ist group is normal control (Normal saline), IInd group is negative control (31st day chlorpromazine 6 mg/kg ip), IIIrd group is standard (levodopa), IVth group is test drug low dose (100mg/kg), Vth group is testing drug(200mg/kg) high dose. Alpha synclein, tau, beta amyloid are the various biomarkers in the present study. Keywords:Alpha synclein, tau, beta amyloid Moringa Oleifera and Rosa canina Parkinsons disease PHARMACOLOGICAL ASSESSMENT OF HERBAL SUSPENSION FOR ANTI PARKINSON ACTIVITY IN RAT ICLTIPB/PH/2023/10042 1 2 2 2 Anish Kumar, Ramesh Kumar Singh, Shailendra Yadav, Devesh Yadav 1 Career point University, Kota (Rajasthan) 2 B. N College of Pharmacy, Sitapur Road, Lucknow 226201 [email protected] Abstract: Baclofen is rapidly absorbed after oral administration but its CNS penetration is relatively limited. The CNS penetration can be enhanced by the virtue of the small size and lipidic nature of solid lipid nanoparticles that may help to cross the various lipid membrane barriers in our body. Thus, SLN of baclofen could be promising in enhancing the efficacy of baclofen. Moreover, SLN are easily bio-degradable and does not cause toxicity as constituted of lipid matrix. In addition, the solid lipid matrix allows for the sustained release of drug. Keywords: Solid lipid nanoparticle, Baclofen, Muscle relaxant activity, Solid lipid. FORMULATION AND EVALUATION OF SOLID LIPID NANOPARTICLES OF BACLOFEN FOR IMPROVEMENT OF MUSCLE RELAXANT ACTION ICLTIPB/PH/2023/10043 Sushant Chaudhary United institute of pharmacy, Naini, Praygraj [email protected] Abstract: Nicotianatobacum (Solanacae)plant is very easily available in Indian environment. Nicotianas are highly toxic plants due to their nicotine. Tobacco plants are also used in plant bioengineering, and some of the more than 70species are grown as ornamentals. The chemistry of tobacco is unique with the presence of a wide spectrum of chemical compounds of which nicotine, solanesol, malic and citric acid were identified as potential chemicals which could be recovered and convertedto value-added products. The effects of nicotine alkaloid are a result of the summation of actionsat ganglionic sites, motor end plates and smooth muscle. The central nervous system is affected, initially by stimulation, resulting in tremors and convulsions, progressing to depression. Mostly death rate occurs from respiratory failure. Recent time death rate occurs use of tobacco at world level by WHO information about 6.0 million population and in India about 1.5 million population by various tobacco originated disease including 30% cancerous disease (By use of Tobacco inform of Cigrate, Pan, Tambacu and various other Tobacco prepared products). Keywords:Nicotine, malic acid, WHO, tobacco. Jitendra Kr. Singh, Nitin Nama, Ramesh Patel, Sudhir Kr. Singh Yadav Career Point School of Pharmacy, Career Point University, Kota. [email protected] REVIEW ARTICLE ON NICOTINE ORIGINATED (ACTIVE AND PASSIVE DISEASES AT 21CENTURY) Abstract: Hydrogels are being researched more and more as local drug d e l i ve r y m e t h o d s b e c a u s e o f t h e ir a d a p t a b l e characteristics, manageable degradation, and capacity to safeguard labile pharmaceuticals. A network of waterinsoluble polymer chains known as a hydrogel is sometimes found as a colloidal gel with water serving as the dispersion medium. Because they may incorporate biologically active substances into their swelling network, hydrogels are desirable materials for the controlled release of medicines. Smart or stimulus responsive biotechnological platforms, or hydrogels, are biomaterials that can be designed to shift from a liquid to a gel in reaction to a stimulus. Biopolymers, sometimes referred to as synthetic and natural polymers, can be used to create hydrogels for drug delivery. There have been a number of significant innovations in the field of hydrogels for therapies delivery as a result of recent advancements in organic and polymer chemistry, bioengineering, and nanotechnology. The polymerization reaction is started by a chemical initiator. Hydrogels have some uses in the human body. The body can experience some environmental factors, such high temperature and a low pH. Because of this, site-specific controlled medication delivery using hydrogels that are temperature- and/or pHsensitive can be used. Hydrogels that respond to particular molecules, such glucose or antigens, can be employed as both drug delivery systems and biosensors. This article's objective is to provide a brief overview of hydrogel uses in the pharmaceutical industry, as well as its features, preparation process, benefits, and drawbacks. Keywords:Hydrogels, Biopolymers, polymer, initiator, pH. DRUG DELIVERY FROM THE HYDROGELS ICLTIPB/PH/2023/10044 Gaurav Tailor, Varsha Yadav, Dr. Meenakshi Bharkatiya, Dr. Amul Mishra Bhupal Nobles Institute of Pharmaceutical Sciences B.N. University, Udaipur (Raj.)-313001 [email protected] ICLTIPB/PH/2023/10045

59 Souvenir Souvenir 60 Abstract: The current research work focuses on investigation of physicochemical and drug likeness properties of selected vitamins and related derivatives by using computational techniques. In order to determine the physicochemical properties such as molecular weight, logP, hydrogen bond donor and hydrogen bond acceptor and drug likeness score we have used several softwares and serves such as PubChem database, and Molsoft software. PubChem was used to collect the canonical smiles of compounds and MolSoft was used to collect the physicochemical data and drug likeness score. Results revealed that most of the vitamins and related compounds obeyed Lipinski's RO5 and fall within recommended ranges of physicochemical and drug likeness properties. Total of more than 30 vitamins and related derivatives have been screened in the study and out of which most of the vitamins and derivatives showed good permeability and bioavailability. This study gives detailed information to evaluate drug likeness and physicochemical properties of selected vitamins and related analogues and might be easily accessible for researchers to select suitable drug candidates for further drug development in the field of drug discovery and drug design. The data obtained helps to modify the existing properties vitamins and related compounds by performing changes in chemical structures. Keywords: Computer Aided Tools, Drug Likeness, Molsoft, PubChem, Vitamins. COMPUTER AIDED INVESTIGATION OF PHYSICOCHEMICAL PROPERTIES AND DRUG LIKENESS PROFILE OF SELECTED VITAMINS AND RELATED ANALOGUES ICLTIPB/PH/2023/10046 Patil Adarsh Arun, Shailendra S. Suryawanshi Department of Pharmaceutical Chemistry, KLE College of Pharmacy Belagavi, KLE Academy of Higher Education and Research, Belagavi-560010, Karnataka, India. [email protected] Abstract: Aloe Vera is well known medicinal plants known to possess valuable medicinal components and hence used to treat many diseases and disorders Hence study of phytochemistry and its druggability chemicals of Aloe Vera is essential to develop the new drug like candidates. The main objectives of research work are to study the chemistry druggability characters of selected plant compounds of Aloe Vera. In order to study the chemistry of selected compounds we have used PubChem database and to understand the druggability of the selected chemicals we have used MolSoft server. PubChem dataset provides the detailed 2D and 3d structures whereas druggability was assessed on the basis of Lipinskies Ro5. Results revealed that the studied 2D and 3D structures gives valuable information about stereochemical aspects of selected plant compounds. Most of the compounds showed the oral druggability with very few violations of Ro5 and hence they have showed the good permeability and bioavailability. This study gives detailed information about stereochemical structures of compounds and also data about physicochemical properties and drug likeness. This data helps to and might be easily accessible for researchers to select suitable drug candidates for further drug development in the field of drug discovery and drug design. Keywords: Computer Aided Tools, Drug Likeness, Molsoft, PubChem, Vitamins COMPUTATIONAL STUDY OF PHYTOCHEMISTRY AND DRUG LIKENESS PROPERTIES OF SELECTED PLANT COMPOUNDS FROM ALOE VERA ICLTIPB/PH/2023/10047 Ronak Dsouza, Shailendra S. Suryawanshi Department of Pharmaceutical Chemistry, KLE College of Pharmacy Belagavi, KLE Academy of Higher Education and Research, Belagavi-560010, Karnataka, India. [email protected] Abstract: Citrus, one of the most significant fruits which are found in more than 50 countries around the globe. Many species of pests have been reported that were infesting various species of citrus crops. Trunk borer, citrus psylla, leaf miner, lemon butterfly, citrus fly, aphids, etc. were reported as major pests of khasi mandarin oranges in a district of Rajasthan i.e. southeastern part of India. These pests eventually result in decreasing productivity of citrus crops in this region. The rejuvenation schedule may be conducted with a multidisciplinary approach after diagnosis of the cause of the decrease was required for the management of pests. The augmentation and conservation of parasitoids squared with other non-pesticides for biological control need to check with a holistic approach in citrus crops. Eventually, it will result in more information about the biology and ecology of parasitoid species. Bio-pesticides, including botanicals, can make a clear, safe and effective replacement to conventional insecticides for controlling pests during an integrated pest management programme. Keywords:Citrus, Kota, Insects, Pests. Abstract: Solid lipid nanoparticles (SLNs) are the first generation of lipid-based nanocarriers that are formulated from lipids, which are solid in the body temperature and stabilized by emulsifiers. SLNs have submicron (less than 1000 nm) sizes. They have numerous advantages such as drug protection against harsh environmental situations, ease of large-scale production using high-pressure homogenization techniques, biocompatibility, and biodegradability. SLNs have also some disadvantages; because of their perfect crystalline structure, they have low drug-loading efficiency and the possibility of drug expulsion due to the crystallization process during the 2 storage conditions. Another drawback is initial burst release which usually occurs with these formulations. In SLNs drug molecules orients between the fatty acid chains or glycerides and during the storage periods and polymorphic changes in solid lipid structures, there is a tendency to the expulsion of previously dissolved drugs in SLNs. Thus ceftazidime and clove oil loaded solid lipid nanoparticles could be promising in enhancing the efficacy of ceftazidime against the bacteria to which it is resistant. Oral administration of this nanoemulsion would increase the bioavailability. SLN is easily bio-degradable and does not cause toxicity as constituted of lipid matrix. In addition, the solid lipid matrix allows for the sustained release of a drug. Keywords:Solid Lipid Nanoparticle, Ceftazidime, Clove oil Rohit Kumar Singh United Institute of Pharmacy Naini, Prayagraj (UTTAR PRADESH) [email protected] A CASE STUDY ON CITRUS ORCHARDS PESTS AND THEIR MANAGEMENT ICLTIPB/PH/2023/10048 1 2 3 Bhujabal Singh Parihar, Dr. Subrat Sharma , Dr. Surabhi Shrivastava 1 Corresponding author Research Scholar, Department of Zoology, University of Kota, Kota, India 2 Associate Professor Department of Zoology Government College, Kota India 3 Course Coordinator and HOD, Wild Life Science, University of Kota, Kota, India [email protected] FORMULATION, EVALUATION, AND ANTI-BACTERIAL ACTIVITY OF CEFTAZIDIME AND CLOVE OIL-LOADED SOLID LIPID NANOPARTICLE ICLTIPB/PH/2023/10049

61 Souvenir Souvenir 62 Abstract: Global pandemic HIV/AIDS causes immune system failure in people, which can result in life-threatening diseases. It is also impossible to ignore the harmful consequences of the human immunodeficiency virus (HIV) in the brain. Many currently available Antiretroviral drugs faces difficulty in crossing the blood brain barrier. A unique approach to treat the neuronal degeneration caused by HIV is provided by nanoparticulate drug delivery systems, which improve the brain absorption of antiretroviral medications. These nanosized drug carriers outperform other traditional drug delivery techniques in a number of ways, including high drug loading capacity, focused action, less toxicity, and enhanced therapeutic impact. A biphasic dispersion of two incompatible liquids, such as water in oil (W/O) or oil in water (O/W) droplets stabilised by an amphiphilic surfactant, is what is known as a nanoemulsion. It is a drug delivery technology that improves the oral bioavailability of medications by making them more soluble. The aim of this project is to create a nanoemulsion loaded with antiretrovirals for the treatment of NeuroAIDS that will possess better bioavailability & solubility than the conventional dosage form. Based on solubility & miscibility studies, Thyme oil was chosen as the oil phase, Tween 80 as the surfactant, Transcutol as the cosurfactant, and distilled water as the aqueous phase for the development of the pseudo-ternary phase diagram on the basis of solubility tests. Different ratios of the surfactant : cosurfactant (Smix) were used 1:1, 2:1,3:1 4:1, and 5:1 along with the oil in different ratios; 9:1, 8:2, 7:3, 6:4, 5:5, 4:6, 3:7, 2:8, and 1:9 for construction of phase diagrams in order to investigate the one which has the maximum region of Nanoemulsion formation. Ultrasonication technique was employed for the fabrication of nanoemulsion. The optimal formulation was obtained through optimization using central composite rotatable design (CCRD). Keywords:immune system, HIV, bioavailablity. Nanoemulsion. PREPARATION OF NANOEMULSION LOADED WITH ANTIRETROVIRAL DRUG FOR THE MANAGEMENT OF NEUROAIDS ICLTIPB/PH/2023/10050 Shivani Tyagi, Dr. Shobhit Kumar Meerut Institute of engineering and technology [email protected] Abstract: Hyperlipidemia is a condition that increases the risk of coronary heart disease (CHD) and atherosclerotic disease (ASHD). Hyperlipidemia acts in concert with smoking, obesity, sedentary lifestyle, and other risk factors to increase CHD. Many people with normal lipid profiles may have ASHD, whereas others with ominous lipid profiles do not have ASHD. Nanotechnology has been widely developed to improve the solubility of active pharmaceutical ingredients (API). Co-crystal discovery has also taken much attention in drug design and development. A combination of the two techniques generates “nano-co-crystallization”, a new approach to obtaining the superior character of drugs. Previously, a new cocrystals of the same API obtained by slow solvent evaporation were utilized for preliminary investigation and further scale-up was done by using the solvent evaporation technique. The present research attempted to develop a Nano-co-crystal (NCC) of an antihyperlipidemic drug. Slow evaporation technique was used in preparation of NCC. The NCCs obtained were then characterized by transmission electron microscopy, differential scanning calorimetry, powder x-ray diffractometry, and Fourier transform infrared spectrophotometry. The NCC suspension was made ready by mixing API as well as co-former exclusively within solvent. At Nearby 2 °C within the condition of ultrasonic, both the solutions quickly transferred into 100 ml of 0.4% (w/v) SLS solution. NCC suspensions were further characterized. NCC suspension was centrifugated near around 5 min at a rotation of 10,000 rpm. At that time supernatant withdrawn as well as the settled particles were dried in a vacuum. The obtained NCC were characterized by DSC, PXRD, and SEM. Dissolution was tested by type 2 apparatus, and diffusion was tested using Franz diffusion cells. NCC formation kinetic, which was evaluated by FTIR, indicated to follow first order. Finally, NCC showed the superior dissolution and diffusion profile than conventional API dosage form. In this study, we demonstrated a promising alternative for improving the dissolution and diffusion of the drug by nano-co-crystallization. Keywords: Microsponges, Stability, Volatile oil, Cosmetic industry, Marketed Products. FORMULATION AND EVALUATION OF NANO-COCRYSTAL OF AN ANTIHYPERLIPIDEMIC DRUG FOR THE MANAGEMENT OF HYPERLIPIDEMIA ICLTIPB/PH/2023/10051 Anusha Jain , Dr. Shobhit Kumar Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology (MIET) NH-58 , Delhi-Roorkee Highway , Meerut- 250005, Uttar Pradesh, India. [email protected] Abstract: MRSA, the virulent bacteria was first identified in hospitals and other health care facilities where susceptible host, often subjection to the demanding pressure of intensive antimicrobial therapy, and the need for invasive procedures created a favorable environment for dispersal. MRSA appeared as a major cause of health care-acquired infections, especially central line-associated bloodstream infections, ventilator-associated pneumonia (VAP) and infection on the surgical site. MRSA is a microorganism that coincide with antibiotic resistance in the hospitals and intensive care units (ICUs), since its first clinical isolation in 1961, suggesting in roughly 40 -60% of bacterial isolates, with persistent multidrug resistance. Certainly, MRSA also leads in the community and animals as an ordinary cause of soft tissue infections and these strains can be dissimilar in terms of their phenotype, drug resistance pattern and clinical end result. MRSA has been observed to develop a resistance to penicillin and cephalosporin-based antimicrobials by the accession of the mecA gene, which is located on a mobile genomic island appointed Staphylococcal chromosome cassette mec (SCCmec) by methicillin susceptible S. aureus. The mecA gene is responsible for the synthesis of a penicillin-binding protein also known as penicillin-binding protein 2a (PBP2a), for which these agents have minimized binding affinity and a fall in pharmacological action. Keywords:MRSA; VAP; S.aureus; mecA gene. Ankita Alice Singh, Raghvendra Raman Mishra Lecturer at Kalaniketan Polytechnic College, Jabalpur, Madhya Pradesh Assistant Professor, Medical Lab Technology, DDU Kaushal Kendra, BHU [email protected] Abstract: The investigation was carried out to determine the chemical compound of Glycyrrhiza glabra root by using Liquid Chromatography- Mass Spectrometry. LC-MS analysis of the aqueous extract of glycyrrhiza glabra root revealed the existence of Liquiritin (10.77), Liquiritigenin (11.56) , Glabridin ( 15.92), Glycyrrhizin (16.68). The results of this study are the platform of using Glycyrrhiza glabra root as a herbal alternative for various diseases. Keywords:Glycyrrhiza glabra, LC-MS, Bioactive compounds. Kalyani U. Chande Dr. D. Y. Patil College of Pharmacy Akurdi, Pune 411044. [email protected] LC-MS DETERMINATION OF BIOACTIVE CONSTITUENTS OF GLYCYRRHIZA GLABRA ROOT EXTRACT ICLTIPB/PH/2023/10052 DEVELOPMENT AND EVALUATION OF PHAGE THERAPY AGAINST MRSA (BIOFILM FORMING) IN EXPERIMENTAL ANIMAL MODEL ICLTIPB/PH/2023/10053

63 Souvenir Souvenir 64 Abstract: The research concentrated on in-silico screening of physicochemical properties of chosen phytoconstituents from the Neem plant utilising computational techniques and a number of tools and services, including the PubChem database and the Molsoft software. In this study, we have been using the Molsoft server and PubMed to screen seven physicochemical parameters of nearly 50 phytoconstituents from the Neem plant. The results indicated that the majority of the therapeutic agents and phytoconstituents adhered to Lipinski's RO5 and have physicochemical qualities that are within acceptable ranges. In purpose to select appropriate drug candidates for further drug development in the sectors of drug discovery and drug design, this study has provided thorough information to assess the drug similar qualities of a few selected medicinal agents. This data assists in the choice of proper active compounds for further drug development in the areas of drug discovery and drug design, so it might be easily accessible for researchers. Keywords: In-Silico, Drug Likeness, Neem, Lipinskies Ro5, MolSoft. IN-SILICO PREDICTION OF DRUG LIKENESS PROPERTIES OF SELECTED PHYTOCHEMICALS OF AZADIRACTHA INDICA ICLTIPB/PH/2023/10054 Prathamesh Magadum, Shailendra S. Suryawanshi Department of Pharmaceutical Chemistry, KLE College of Pharmacy Belagavi, KLE Academy of Higher Education and Research, Belagavi-560010, Karnataka, India. [email protected] Abstract: The current study employs computational methods and a variety of software and services, including the PubChem database and the Molsoft software, to screen the physicochemical properties of chosen phytoconstituents from the Arjuna (Terminalia arjuna) plant. In this study, we used the Molsoft server and PubMed to screen seven physicochemical parameters of over 43 phytochemicals from the Arjuna (Terminalia arjuna) plant. Results showed that the majority of the phytochemicals followed Lipinski's RO5 and have physicochemical properties that are within acceptable ranges. In order to choose appropriate drug candidates for further drug development in the fields of drug discovery and drug design, this study provides thorough information to assess the drug similarity features of a few chosen medicinal compounds. This information aids in the selection of appropriate drug candidates for further drug development in the areas of drug discovery and drug design, and it may be freely accessible for researchers. Keywords: Arjuna; Pubchem; PubMed; RO5; medicinal compounds. INVESTIGATION OF PHYSICOCHEMICAL PROPERTIES OF SELECTED PHYTOCONSTITUENTS OF ARJUNA BY COMPUTER AIDED DRUG DESIGN TOOLS ICLTIPB/PH/2023/10055 Shreyansh, Shailendra S. Suryawanshi Department of Pharmaceutical Chemistry, KLE College of Pharmacy Belagavi, KLE Academy of Higher Education and Research, Belagavi-560010, Karnataka, India. [email protected] Abstract: Alzheimer disease (AD) is a neurodegenerative disease that impairs mental ability development and interrupts cognitive functions. AD is the primary cause of dementia in people above the age of 60. Around 50-75 % of people with dementia have Alzheimer's. AD is a progressive and chronic neurodegenerative disorder which displays global cognitive decline involving memory loss, orientation, judgment and reasoning. Several pathogenic pathways involved in the disease development and progression include, beta-amyloid plaque formation, inflammatory cascade, cholinergic deficits, oxidative stress etc. Beta-amyloid plaques function as a neurotoxin by preventing in neuron-to-neuron communication at synapses, while tau tangle prevent the passes of essential molecules and nutrients inside neurons which causes axonal transport dysfunction and neuronal loss. Plants provide wealth of bioactive components, which exerts a substantial strategy for the treatment of neurological disorders such as Alzheimer's disease. Such bioactive components secreted by the plants are known as secondary metabolites. Secondary metabolites produced bythe plant as the part of their defense mechanism, Alkaloids are one among them which play an important role in memory enhancement or serves as brain tonic. They play very important role mainly due to their strong antioxidant, anxiolytic and antidepressant properties. They have been also used in the treatment of neurodegenerative diseases. Crinine, augustamine or galanthamine which is used in the treatment of neurodegenerative disease such as Alzheimer are isolated from plants. Present study is about the application of such plant moiety in memory enhancement to control dementia. Keywords: Neurodegenerative, Chronic, Beta-Amyloid, Synapses, Antioxidant, Anxiolytic, Antidepressant etc. Sunita Roy, Bhawana Sati Department of pharmacy, Banasthali Vidhyapith, Banasthali University, Rajasthan-304022 [email protected] Abstract: Wrinkles on the face and aging of the skin are an undesirable effect of photodamage and ultraviolet radiation. Serum has a quick absorption and ability to penetrate deep layers of the skin, as well as a non-oily finish and a deep formula with a very high amount of active ingredients. Based on these properties, the purpose of this work was to make serum using polyherbal extract. Eclipta alba extract and almond oil face serum is a highly concentrated cosmetic product. Skin Aging is a complex biological process influenced by a combination of endogenous (intrinsic) and exogenous (extrinsic) factors. Because of the fact that skin health and beauty is considered one of the principle factors representing overall “well-being” and the preparation of “health” in humans. Eclipta Alba having important role in traditional ayurvedic and unani system of health and herbal medicine. The principle constituent of Eclipta Alba is coumestan derivative like Wedelolactone, di-methyl Wedelolactone, which act as natural Rejuvenator. All Parts of Eclipta-alba and chemical constituent mostly used as antioxidant, Almond oil has anti-inflammatory properties and is used as a skin moisturizing agent. It also has anti-oxidant properties that can prevent premature aging. Facial serum was tested for its pH, physical appearance, spredability, viscosity, microbial testing, cyclic temperature test, etc. The results of the stability study show that there was no change in visual acuity, homogeneity. Keywords: Rejuvenator, Anti-inflammatory, anti-oxidant, Premature aging, Penetrate. APPLICATION OF HERBAL TECHNOLOGY IN MEMORY ENHANCEMENT TO CONTROL DEMENTIA CAUSED BY ALZHEIMER DISEASE ICLTIPB/PH/2023/10056 FORMULATION AND EVALUATION OF POLYHERBAL EXTRACT FACE SERUM ICLTIPB/PH/2023/10057 Virashri Dhumal Department of Pharmaceutical Science, Jayoti Vidyapeeth Women's University, Jaipur, Rajasthan, India [email protected]

65 Souvenir Souvenir 66 Abstract: Metabolic syndrome has become a leading health concern or rather pandemic in developing countries. In recent years, enzyme stearoyl-CoA desaturase has emerged as a promising target for the design and development of novel therapeutics for the treatment of metabolic syndrome includes obesity, diabetes and insulin resistance. Validated pharmacophore models were developed and used for virtual screening. The retrieved hits were sorted on the basis of fit value, estimated value and zero Lipinski's violation. The most potent hits were subjected to molecular docking studies. Pharmacophore models were developed using a series of 52 compounds containing peteridione ring. All the 52 compounds were dividing into training and test set for development of Pharmacophore model. The best model comprising of 5 features (3hydrobhobic,2 HBA) with root mean square (RMS) of 0.81, correlation of 0.90 was considered as best. The model cleared Fischer randomization test. The validated model was used for mining of NCI database containing 2.6 Lac compounds. In total 250 hits were retrieved out of which 3 showed most promising fit and estimated value. All the three hits showed good molecule docking score of 147.07,144.86,150.03. In conclusion, through our sequential approach we have identified three potent and novel SCD inhibitors with potential in the treatment of metabolic syndrome. Keywords: Syndrome, diabetes, pharmacophore, SCD inhibitors. LIGAND BASED PHARMACOPHORE MODELLING, VIRTUAL SCREENING AND MOLECULAR DOCKING TO IDENTIFY NOVEL SCD INHIBITORS FOR THE TREATMENT OF METABOLIC SYNDROME ICLTIPB/PH/2023/10058 Pragya Sharma, Sarvesh Paliwal Department of Pharmacy, Banasthali Vidyapith, Rasjasthan-304022, India. [email protected] Abstract: Most of the studies focus on the effects of planting conditions on the concentrations of pharmaceutically active metabolites, with biological factors such as the impact of endophytic fungi generally being unnoticed. The term "endophytic fungus" describes fungi that form a mutually beneficial symbiotic relationship with their host plant and remain there throughout their whole or portion of their life cycle without causing any negative effects or diseases. Endophytic fungi were isolated from medicinal plant Ajuga bracteosa, i.e., Irpex lenis and Crinipellis wandoensis inoculated in plant Perilla frutescens (L.) Britt. There were four groups i.e., group A (control group) which was not inoculated with any fungus, group B was inoculated with I. lenis, group C was inoculated with C. wandoensis and group D was inoculated with both the fungi. Spectrophotometric determination by DPPH and FRAP Assay. P. frutescens is a perennial member of the Lamiaceae family of mint plants that is used for food, medicine, fragrance, and decorative purposes. Its synonym is Ocimum frutescens L. The present study showed that there is significant (p<0.05) variation in antioxidant potential of plants inoculated with two different fungi i.e., I. lenis and C. wandoensis as compared to group A. In this study, fungi inoculated plants showed higher potential of anti-oxidant. Anti-oxidant potential of the plants depends on their phytochemicals mainly phenols and flavonoids. Both the fungi increase the phytochemicals in fungi inoculated plants and also increase anti-oxidant potential of plants. Keywords:metabolites, fungus, symbiotic, flavonoids. IMPACT OF ENDOPHYTIC FUNGI ISOLATED FROM AJUGA BRACTEOSA WALL. EX BENTH. ON ANTI-OXIDANT POTENTIAL OF PLANT PERILLA FRUTESCENS (L.) BRITTON ICLTIPB/PH/2023/10059 Kiran Sharma, Rachna Verma Shoolini University of Biotechnology and Management Sciences, Solan (H.P) [email protected] Abstract: The present study was aimed to evaluate physical constants and develop the HPTLC finger print profile of Seed Extracts of Vernonia anthelmintica (L) and Trachyspermum ammi (L) HPTLC studies were carried out using CAMAG HPTLC system equipped with Linomat IV applicator. Extract showed the presence of alkaloids, flavonoids, steroids, saponins, resins, essential oils, terpenoids, polyphenolic compounds. HPTLC finger printing analysis of Seed extracts of Vernonia anthelmintica (L) and Trachyspermum ammi (L) revealed presence phytoconstituents. VAPEE extract showed 9 peaks at 366 nm with Rf values 0.03-0.85, VACE extract showed 10 peaks at 366 nm with Rf values 0.03-0.82, VAHAE extract showed 9 peaks at 254 nm with Rf values 0.04-0.82, at 366 nm showed 12 peaks with Rf values 0.33- 0.83 & at 560 nm showed 9 peaks with Rf values 0.03- 0.67. TAPEE extract showed 11 peaks at 366 nm with Rf values 0.06-0.87 TACE extract showed 7 peaks with Rf values 0.11 - 0.90. TAHAE extract showed 6 peaks with Rf values 0.01-0.89 showed maximum concentration. The chromatogram shows presence of multiple peaks which indicate diverse composition of extract. It can be concluded that HPTLC fingerprint analysis of Seed extracts of Vernonia anthelmintica and Trachyspermum ammi can be used as a diagnostic tool for the correct identification of the plant, phytoconstituents and it was appropriate method for standardization of the extract. Keywords: Vernonia anthelmintica(L) and Trachyspermum ammi(L),Phytochemical Screening, Physical constants, HPTLC Fingerprinting. 1 2 Vishal S. Adak , M. K. Gupta 1 Research Scholar, Career Point University, Kota, Rajasthan, India. 2Dean and Principal, School of Pharmacy, Career Point University, Kota, Rajasthan, India. [email protected] Abstract: Stinging nettle (Urtica dioica, L. Urticaceae) is a ubiquitous herb which is available in large part of the world. Urtica dioica is a moderately shade-tolerant species, which occurs on most moist or damp, weakly acid or weakly basic, richly fertile soils. Its stems and leaves are densely covered with stinging hairs, which release potentially pain-inducing toxins. The genus Urtica is derived from word 'uro' to burn or 'urere' denotation to sting. Vernacular name of the plant are Bichu Butti in Hindi and Punjabi. A broad range of environmental factors changes with the elevation of the natural growing site. These factors include precipitation, mean temperature, daily thermal amplitudes, soil fecundity, wind speed, temperature extremes, atmospheric pressure, duration of snow-cover, length of the vegetation period, and radiation intensities. Plants respond to these climatic shifts by adjusting key physiological processes. However, the studies on plant response on biological activities with respec t to these fa c tor s a re poorl y ava i l able. Spectrophotometric determination via dpph and frap assay. The present study reveals a significant (p<0.05) difference in antioxidant potential attributes among six different populations of U. dioica in Himachal Pradesh. Among the different populations, plants growing in moist and damp habitat exhibit highest antioxidant potential and are positively correlated with altitude. Highest the antioxidant potential means the plant is more capable to fight against ROS production and protect cells against free radicals which may cause many diseases like cancer. Keywords: Stinging nettle, ubiquitous, dpph assay. PRELIMINARY PHYTOCHEMICAL SCREENING AND HPTLC FINGER PRINTING ANALYSIS OF SEEDS EXTRACTS OF VERNONIA ANTHELMINTICA (L) AND TRACHYSPERMUM AMMI (L) ICLTIPB/PH/2023/1060 ANTIOXIDANT POTENTIAL OF URTICA DIOICA LEAVES GROWING WILD IN DIFFERENT FOREST REGIONS OF HIMACHAL PRADESH ICLTIPB/PH/2023/1061 Diksha Sharma, Sunil Puri Shoolini University of Biotechnology and Management Sciences, Solan (H.P.) [email protected]

67 Souvenir Souvenir 68 Abstract: Medicinal plants have been exploited for therapeutic purposes since the dawn of civilization and have long been acknowledged essential to human health. The purpose of this research is to examine the scientific evidence for using the therapeutic herbal plants Jasminum officinale and Fagopyrum esculentum to treat diabetes. The antiinflammatory activities of these plants were evaluated by BSA (Bovine serum albumin) with fractionation solvent properties and methanolic crude extract methanol-polar, chloroform-non-polar, ethyl acetate -semi polar and aqueous-polar as one of the bases of traditional use. Spectrophotometer determination for anti-inflammatory activity. It was observed that methanolic crude extract followed by ethyl acetate fraction of Jasminum officinale and Fagopyrum esculentum leaves as compared to the standard drug diclofenac sodium significantly (p<0.05) inhibited the denaturation of BSA exhibiting antidenaturation activity. This is can be attributable to higher solubility of these compounds in ethyl acetate than the other solvents tested. Overall, the study suggested that ethyl acetate fraction of these herbs have significant therapeutic properties, and their anti-inflammator y activity recommends further clinical investigations to get insight into the mechanisms of action in curing diabetes mellitus. Jasminum officinale and Fagopyrum esculentum will however be in order to isolate potential lead antiinflammatory compounds. Keywords: medicinal plants, BSA, diabetes mellitus, solvents, Jasminum officinale. ANALYSIS OF ANTI-INFLAMMATORY ACTIVITY OF JASMINUM OFFICINALE L. AND ERIGERON ANNUUS (L.) PERS. FOR THE TREATMENT OF DIABETES MELLITUS IN HIMACHAL PRADESH OF WESTERN HIMALAYAS ICLTIPB/PH/2023/1062 1 1 Mehak , Dr. Rachna Verma 1 School of Biological and Environmental Sciences, Shoolini University of Biotechnology and Management Sciences, Solan Himachal Pradesh 173229, India [email protected] Abstract: Most of the studies focus on the effects of planting conditions on the concentrations of pharmaceutically active metabolites, with biological factors. Cotoneaster microphyllus Wall. ex Lindl. is an evergreen unpopular plant belonging to the family rosaceae, mostly found in the hill station areas. Traditionally the raw fruits of this plants are eaten and believed to cure asthma. The stem is used as toothbrush to get rid of many oral problems. Fruits are made into a paste and mixed with mustard oil and applied on the skin against irritation. Cotoneaster microphyllus Wall. ex Lindl. is a rich source of bioactive constituents which are distributed in the parts leaves, fruit, flowers of the plant. Spectrophotometric determination by DPPH and FRAP AThe present study reveals a significant (p<0.05) difference in antioxidant potential attributes among different plant parts of Cotoneaster microphyllus Wall. ex Lindl. growing in District Shimla of Himachal Pradesh. Among different plant parts, young leaves exhibit highest antioxidant potential. Highest the antioxidant potential means plant is more capable to reduce the effect of free radicals. Keywords: biological factors, asthma, free radicals. EVALUATION OF ANTIOXIDANTS OF COTONEASTER MICROPHYLLUS WALL. EX LINDL. LEAVES & FRUITS GROWING IN DISTT. SHIMLA OF HIMACHAL PRADESH. ICLTIPB/PH/2023/1063 Ritika Dadhwal, Dr. Ritesh Banerjee Shoolini University of Biotechnology and Management Sciences, Solan (H.P.) [email protected] Abstract: In pharmacy the word substitute and adulterant are noted under the umbrella of adulteration. The different types of adulteration is now adays commonly used in ayurvedic formulations intentionally or non-intentionally so we must know the types and available commonly used adultrants in an ayurvedic formulations ayurvedic formulations are mainly divided into two groups viz. (1) Kasthausadhi (predominantly plant drugs) and (2). Rasausadhi (predominantly metals and minerals). There are several categories of Kasthausadhi formulations such as Asavaristra, Avleha, Grafa Churena, Taila etc and of Rasausadhis such as Bhasma, Pisti, Lauha, Kapibadkva, Rasayana etc. Especially the crude drugs adulteration in Ayurveda a much-needed specification is the need of the hour. There can be a fine line between adulterant and additive; chicory may be added to coffee to reduce the cost this is adulteration if not declared, but may be stated on the label. In general scene there should not be bondages with declaration and without declaration. The term "contamination" is usually used for the inclusion of unwanted substances due to accident or negligence rather than intent. Adulterants added to reduce the amount of expensive product in illicit drugs are called cutting agents. In context with Ayurveda the Pratinidhi Dravya (substitutes) has come into exist for substitution and Apamishrana has been used for adulteration. Study of these type of adulterations useful to avoid the use of any of them by the any ayurvedic companies. Keywords : a d u lte r a tion, a y u r ve d i c, a y u r ve d a , contamination, substitutes. REVIEW ON ADULTERANTS IN THE AYURVEDIC FORMULATION ICLTIPB/PH/2023/1064 Madan Lal, Ziyaul Haque, Peeyush Sharma, Ruqaiya Jamal Department of Pharmacogonosy, Faculty of Pharmacy, Maulana Azad University, Jodhpur [email protected] Abstract: The application of artificial intelligence in pharmaceutical technology has grown over time, and it now helps to better comprehend the correlations between various formulation and process factors while also saving time and money. The process of developing new drugs might be drastically altered by astounding increases in processing capacity and developments in AI technology. Technologies that are fast developing and that might be used in the creation and processing of pharmaceutical goods include neural networks, genetic algorithms, and fuzzy logic. Artificial intelligence can be used to identify substances that may interact with "undruggable targets." For drug development, AI doesn't rely on predefined targets. Therefore, preconceived notions and generalised knowledge have no place in the medication development process. Drug screening might be moved from the bench to a virtual lab using AI, where findings could be produced more quickly and potential targets may be narrowed down without requiring a lot of experimental input or labour hours. Additionally, machine learning techniques and predictive model software work together to identify target-specific virtual molecules and link them to the appropriate targets while maximising safety and effectiveness characteristics. By limiting the variety of produced compounds that are later examined in either in vitro or in vivo systems, AI systems can reduce attrition rates and research and development costs. The data on small-molecule modulator probes or their structural biology may be employed with a range of in silico strategies for profile selection, such as virtual ligand or structurebased design procedures. In this review, the major causes of attrition rates in new drug approvals, the possible ways that AI can improve the efficiency of the drug development process and collaboration of pharmaceutical industry giants with AI-powered drug discovery firms are discussed. Keywords: Artificial Intelligence, In-silico, Machine Learning, Research and Development. A REVIEW ON ARTIFICIAL INTELLIGENCE IN NEW DRUG DEVOPMENT : PRESENT STATUS AND FUTURE PROSPECTS ICLTIPB/PH/2023/1065 Bidyut Bikash Laskar, Deep Bose, Akash Sharma Institute of pharmacy, Assam Don Bosco University, Kamrup (M) [email protected]

69 Souvenir Souvenir 70 Abstract: On a world scale, obesity has reached epidemic proportion and is a major contributor to the world burden of chronic disease and disability. According to WHO, obesity is related to cardiovascular disease, hypertension, endocrine disorders, diabetes mellitus, gallbladder disease, cancer, metabolic disturbances, osteoarthritis, gout & pulmonary disease, as well as psychological issues, including social bias, prejudice, discrimination, and overeating.. Many anti-obesity drugs are available in the market. The present work was under taken to evaluate the antiobesity effect of chenopodium album leaves extracts]' in Cafeteria diet induced obesity in rats. For the purpose ethanolic & aqueous extract of Chenopodium album leaves were prepared and screened for phytochemical constituents and antiobesity activity. For pharmacological activity Wistar rats weighing 150-200 g were randomly divided in to seven groups (n=6/group). Group ? served as normal control Group ?? served as CD control & Group ??? received standard drug Orlistat (30 mg/kg); Groups ?V & V were administered with aqueous extract of Chenopodium album leaves (250 & 500 mg/kg respectively) and Groups V? & V?? received ethanolic extract of Chenopodium album leaves (250 & 500 mg/kg respectively). All treatments were given orally, started after 6 weeks feeding with CD (except normal control group) and continued for six weeks along with CD. Weight gain, feed intake, BMI, obesity index, lipid profile, blood glucose and body fat depots content were the parameters evaluated. The phytochemical screening of ethanolic & aqueous extracts showed the presence of alkaloids, saponins, quinones, coumerins, sugar and gums. Ethanolic and aqueous extract of Chenopodium album leaves at 250 and 500 mg/kg showed reduction in weight gain, feed intake, BMI, obesity index and significant decrease in serum glucose, triglyceride, total cholesterol with increase in HDL level, Also these was significant decrease body fat depots when compared to CD control group. From the present study it can be concluded that aqueous and ethanolic extracts of Chenopodium album leaves extracts possess significant antiobesity activity against Cafeteria diet induced obesity in rats. It appeared from the study that, the activity of ethanolic and aqueous extract of Chenopodium album leaves could be due to presence of flavonoids, tannins, diosgenin and saponins. However, detailed phyto-pharmacological study of leaves extracts will be useful to pin point the activity. Keywords:Chenopodium, BMI, body fat, phyto-harmacological. PRECLINICAL SCREENING OF CHENOPODIUM ALBUM LEAVES EXTRACTS FOR ANTI-OBESITY ACTIVITY ICLTIPB/PH/2023/1065 Ayushi Bhatnagar, Ankur Garg Vivek College of Technical Education, Bijnor [email protected] Abstract: For finding the related substances that are present in the drugs, in-silico studies are preferred as a current trend in pharmaceutical analysis to find out the impurities of a drug. The virtual screening of selected RS may indicate them as potential DD leads. The extension of impurity profiling, after toxicity assessment, to ADME estimation, molecular docking ,QSAR studies and bioactivity prediction, has broadened the determinations of drug analysis. Through this study toxicity level of a drugs can be predicted, identify and quantify by an advance analytical technique like HPLC and can be characterized and fragmented like LC-HRMS, GCMS etc. This may lead to the evaluation of drug likelihood of toxic and nontoxic RS. Thus, in-silico profiling of drugs and RS might be an advanced. It may help extending classical PDA with insilico determinations to widen horizon from regulatory toxicology evaluation towards drug discovery. The related substances which are having a low toxicity level can be further screened out to check their therapeutic efficacy. Associating Pharmaceutical drug analysis to new drug discovery is very much important in order to find a new lead. Therefore, a new approach must be incorporating for insilico profiling of drugs. Keywords:HPLC, LC-HRMS, GCMS, PDA, RS. CURRENT TRENDS IN PHARMACEUTICAL ANALYSIS TO PROMOTE CONTEMPORARY DRUG DISCOVERY BY IN- SILICO PROFILING OF DRUGS AND RELATED SUBSTANCES ICLTIPB/PH/2023/1066 Achangliu Pamai, Vivek Kumar Sah, Waibiangki Lyngdoh Institute of Pharmacy, Assam Don Bosco University, Tapesia- 782402 [email protected] Abstract: Nanosponges are colloidal structures that contain solid tiny particles with cavities and mesh-like networks to encapsul ate wide va rieties of subs t ances l i ke antineoplastic, protein and peptide, volatile oil, DNA, etc. Nanosponges show an advantage over microsponges as the diameter of the former is below 1 μm and that of the latter is 10–25 μm with a void size around 5–300 μm. Moreover, nanosponges are stable at a temperature of about 300 °C whereas microsponges are up to 130 °C. The methods for the preparation of microsponges include quasi-emulsion solvent diffusion liquid–liquid suspension polymerization whereas methods for nanosponges preparation include solvent evaporation method, emulsion solvent evaporation method, ultrasound-assisted synthesis, hyper crosslinked -cyclodextrin and interfacial phenomenon method. The mechanism of action for luliconazole's antifungal activity is yet to be deciphered. In fungal infections, the drug is expected to localize in high concentrations in the epidermis, dermis, and deeper layers of the skin as these areas are affected. However, the low aqueous solubility of luliconazole (0.0034 ± 0.000067 mg/mL) is of major concern as it results in poor bioavailability on topical delivery via the dermal route. Keywords:Nanosponges, luliconazole, beta-cyclodextrin. FORMULATION AND EVALUATION OF TOPICAL HYDROGEL OF LULICONAZOLE LOADED BETA CYCLODEXTRIN NANOSPONGES ICLTIPB/PH/2023/1067 Shubhi Yadav United institute of pharmacy, naini Prayagraj (Uttar Pradesh) [email protected] Abstract: Plants have been one of the important sources of medicines since the beginning of human cultivation. There is a growing demand for plant based medicines, health products, pharmaceuticals, food supplements, cosmetics etc. A review of chemical constituents present in various parts of Thymus vulgaris and their pharmacological actions is given in the present articleThymus vulgaris, is a commonly used herb in Ayurvedic medicine. Although the review articles on this plant are already published, this review article is presented to comply all the updated information on its phytochemical and pharmacological activities, which were performed by widely different methods. Studies indicate that Thymus vulgaris possesses antiacne, lowering blood pressure, helping to alleviate cough, boosting immunity, disinfectants, repelling pests, aromatherapy, boosting mood, culinary uses, antibacterial and anticancer. Various other effects like antiulcer, antiviral, antihepatotoxic, antifungal and herpes simplex have also been studies. These results are very encouraging and indicate this herb should be studies more extensively to confirm these results and reveal other potential therapeutic effects. A review of chemical constituents present in various parts of Thymus vulgaris and their pharmacological actions is given in the present article. Keywords: Thymus vulgaris; ayurvedic medicine; blood pressure; pharmacological actions. THYMUS VULGARIS: A PHYTOPHARMOLOGICAL REVIEW ICLTIPB/PH/2023/1068 Nitin Shukla, Manish Indoria, Rambir Singh Department of Pharmacy, Maharishi Arvind University, Jaipur, Rajasthan, India [email protected]

71 Souvenir Souvenir 72 Abstract: Healthcare innovation has always sought to enhance patient outcomes, increase access, and lower costs. Healthcare delivery strategies and public health policies have also changed care. New healthcare innovations can change the industry and save lives. Telemedicine-based medical decision-making is one example. Protecting personal data, combating cyberattacks, and providing equal health care are challenges of innovation. Healthcare innovation must overcome these obstacles to succeed and last. Recent healthcare advancements have improved patient care and health. Telemedicine, computerized health records, and medical equipment improvements are examples. Mobile EHRs and wearable devices are changing how patients manage their health and engage with doctors. Precision medicine can also customize medicines to each patient's DNA. These advances are improving healthcare outcomes, prices, and access. Despite progress, affordability and availability remain important issues. With continued investment and effort, the healthcare system will improve, benefiting everyone. Artificial and Human Intelligence Incorporating Others Will Shape Health Care. Due to the necessity to automate evidence-based business choices and the availability of platform-grade and modular machine learning or deep learning solutions, the global healthcare industry is likely to adopt AI. AI technology has a lot of potential in Saudi Arabia and the UAE, where 66% and 62% of respondents are open to using it for therapy. AI solutions won't replace doctors, but they'll make them more efficient and accurate. AI will help doctors find previously untraceable disease patterns, improving healthcare research and service. However, AI platforms may handle and analyse the current increase in patient-generated data, which may benefit many healthcare industries. Keywords:innovation, cyberattacks, AI, Healthcare. INNOVATION TECHNOLOGY FOR EFFICIENCY IN HEALTHCARE SYSTEM ICLTIPB/PH/2023/1069 1 2 N.Indumathi , Someshwaran G, Harshith P, Dinesh J S Department of Computer Science and Applications(MCA), SRM Institute of Science and Technology. Ramapuram Campus.Chennai. [email protected] Abstract: Healthcare innovation has always sought to enhance patient outcomes, increase access, and lower costs. Healthcare delivery strategies and public health policies have also changed care. New healthcare innovations can change the industry and save lives. Telemedicine-based medical decision-making is one example. Protecting personal data, combating cyberattacks, and providing equal health care are challenges of innovation. Healthcare innovation must overcome these obstacles to succeed and last. Recent healthcare advancements have improved patient care and health. Telemedicine, computerized health records, and medical equipment improvements are examples. Mobile EHRs and wearable devices are changing how patients manage their health and engage with doctors. Precision medicine can also customize medicines to each patient's DNA. These advances are improving healthcare outcomes, prices, and access. Despite progress, affordability and availability remain important issues. With continued investment and effort, the healthcare system will improve, benefiting everyone. Artificial and Human Intelligence Incorporating Others Will Shape Health Care. Due to the necessity to automate evidence-based business choices and the availability of platform-grade and modular machine learning or deep learning solutions, the global healthcare industry is likely to adopt AI. AI technology has a lot of potential in Saudi Arabia and the UAE, where 66% and 62% of respondents are open to using it for therapy. AI solutions won't replace doctors, but they'll make them more efficient and accurate. AI will help doctors find previously untraceable disease patterns, improving healthcare research and service. However, AI platforms may handle and analyse the current increase in patient-generated data, which may benefit many healthcare industries. Keywords:innovation, cyberattacks, AI, Healthcare. INNOVATION TECHNOLOGY OF ARTIFICIAL INTELLIGENCE FOR IMPROVING EFFICIENCY IN HEALTHCARE SYSTEM ICLTIPB/PH/2023/1070 1 2 N.Indumathi , Someshwaran G, Harshith P, Dinesh J S Department of Computer Science and Applications(MCA), SRM Institute of Science and Technology. Ramapuram Campus.Chennai. [email protected] Abstract: The existence of multiple complex chemical compounds with varying compositions that arise as secondary metabolites is what gives medicinal plants their therapeutic abilities. The monoecious or dioecious plants, shrubs, vines, and trees that make up the Euphorbiaceae family all produce latex. With around 2000 species, the genus Euphorbia (also known as spurges, Euphorbiaceae) is the third largest genus of flowering plants. These species are found all across the world. Depending on the population, different plants are used to treat different ailments. The current study is a systematic attempt to analyse the three species, the main medicinal plants of the genus Euphorbia namely E. hirta, E. hypericifolia, E. thymifolia, belonging to the family Euphorbiaceae according to their pharmacognostic, phytochemical, and pharmacological research. Online databases (Google Scholar, PubMed, Scopus, and ScienceDirect) were searched and published research articles (1980–2020) were gathered and reviewed. Numerous euphorbia species have been used in India to alleviate inflammation of the respiratory system and asthma. It was observed in study that all the three species have some of the common activities like anti-tumor, anti-asthmatic, antidiabetic, analgesic, antipyretic, antioxidant activity, anti-inflammatory activity, antispasmodic, antifungal activity, antibacterial activity, antimicrobial but E. hirta additionally showed galactogenic activity, antiasthmatic activity, antidiarrheal activity, antifertility activity, antiamoebic activity, gonorrhea, against jaundice and digestive issues, hepatoprotective, platelet augmentation acti v it y, gastroprotecti ve, anticonvulsant, neuroprotective and anxiolytic which may be attributed to the euphorbin content found specifically in E. hirta. It was observed in present study that Euphorbia hirta species showed numerous activities when compared to the other two varieties followed by Euphorbia thymifolia and then Euphorbia hypericifolia. It has been found from the above study that phytopharmacological profile of E. hypericifolia and E thymifolia needs to be explored more extensively as its various medicinal aspects have remained untouched. Keywords:flowering plants; online database; Scopus. SYSTEMATIC COMPARATIVE ANALYSIS OF PHARMACOGNOSTIC PROFILE OF SOME SPECIES OF GENUS EUPHORBIA. ICLTIPB/PH/2023/1071 Navjot Kaur, Dr. Satnam Singh ASBASJSM College of Pharmacy, Bela, Ropar, Pb. 140001 [email protected] Abstract: Disinfectants plays a crucial role in controlling the spread of pathogens responsible for carrying out the diseases. Disinfection and sterilization are essential for ensuring that the pathogen get killed and not transmitted to another objects. One of the high needs for disinfectants can be overcome by using disinfectants that are made from natural ingredients known as natural disinfectants. Garbage Enzyme (GE) is one way that can be used as an organic waste-based disinfectant, it can be produced by fermentation process in the presence of Saccharomyces cerevisiae. The efficacy of GE was evaluated and compared with Commercial products. In this study, hatkora peels, kitchen waste and sugarcane leftover after juice extract was used, all GE show amylase, caseinase and protease enzyme activity and none of the sample show lipase enzymatic activity. For cellululase enzyme activity the supertanant (k2) and filtrate (k 3) of kitchen waste does not show. The antimicrobial activity of the GE and different Commercial products was done using agar well diffusion method, GE from Hatkora show highest zone of inhibition among the other GE even than enzyme based marketed product (MP) at 100% concentration, while dettol was recorded with the highest zone of inhibition compare to GE. For phenol coefficient test, dettol, ultra-swab, and lizol showed more efficacy than phenol and the GE show less efficacy than Phenol against Pseudomonas aeruginosa, bacillus subtilis, and Salmonella typhi. However, GE from hatkora peels showed the best disinfectant activity among all the GE that has been studied. From the finding show that commercial products show more effect than Garbage enzyme even in a low concentration. Keywords: Garbage enzyme, efficacy, enzymatic activity, phenol coefficient, antimicrobial. PRODUCTION OF NATURAL DISINFECTING AGENTS FROM GARBAGE ENZYME & COMPARISON OF THEIR EFFICACY WITH COMMERCIALLY AVAILABLE PRODUCTS ICLTIPB/PH/2023/172 1 1,2 2 Liza Boro , Kmensiful Binan , K Thanzami 1 Assam Don Bosco University, Tepesia, Sonapur, Assam 782402, 2 Department of Pharmacy, RIPANS, Aizawl, Mizoram-796017 [email protected]

73 Souvenir Souvenir 74 Abstract: Yashada bhasma has been found to be very effective in treating conditions like diabetes, eye disorder, urinary disorder etc. Since bhasma is a metallic preparation, to prove its quality, various classical as well as modern techniques are available for that among them are (XRD, DLS, SEM and EDAX) etc. Yasad bhasma containing zinc, Zinc plays unique biological role and its deficiency leads to many diseases. Hence, the present work deals the analysis of Yasad bhasma of three different brands, to compare and know the quality of commercial bhasma in market. Yasad bhasma were purchased from local Ayurvedic market Amravati, India. of three manufacturers, namely Shree Baidyanath (BYB), Shree Dhutpapeshwar (DYB) and Unjjha pharmaceuticals (DYB) consider to compare and know the quality of commercial bhasma on market. Based on a study, the traditional Yasad bhasma procedures (BYB and DYB) produce better results; therefore, both samples should be used for the analytical analysis. The XRD analysis of both Yashada bhasma shows hexagonal ZnO crystalline phase. Both Yashada bhasmas stability is confirmed by the zeta potential value. The Atomic absorption spectroscopy showed the presence of Zinc as major component along with the other elements like Fe, Pb, Cu, Sn, Mg, Mn in both commercial product samples. FTIR analysis shows the presence of ZnO, C=C, OH functional groups in both samples. DYB shows less particle size than BYB. So bioavailability of Dhootpapeshwar Yashada bhasma was greater than Baidyanath YB. So DYB can be considered better for internal administration. By analytical method of examination along with classical method this is reveal that DYB is better for therapeutic efficacy and is a step towards establishing the scientific reasons behind the safety and efficacy of this ancient system of medicine. Keywords: Yashada bhasma, zinc, FTIR, DYB, ancient system, medicine. COMPARATIVE QUALITATIVE ANALYSIS OF YASAD BHASMA WITH CLASSICAL AND MODERN PARAMETERS ICLTIPB/PH/2023/173 S. A. Chavhan, Dr. V. S. Adhao Dr. Rajendra Gode College of Pharmacy, Malkapur Dist. Buldhana (MH). [email protected] Abstract: Heterocyclic ring are structural feature of many antiinflammatory compounds, among them quinoline nucleus having variety of therapeutic activities, posses a benzene ring fused to alpha and beta position of a pyridine ring. In this method 2, 4 –substituted quinoline derivatives are prepared through Vilsmeier reaction by reaction of O-methyl acetanilide with DMF and POCl3, with toluene, HI, and HBr. In this research work the substituted quinoline derivatives synthesized through Vilsmeier Haack reagent. In the present study on acetylation was found to be better support on basis of the yield of the product. Quinoline derivatives will synthesize by using different Vilsmeier method as well as evaluated for biological evaluation for better antiinflammatory activity in future. Keywords: Quinoline, heterocyclic, Anti-inflammatory activity. SYNTHESIS, BIOLOGICAL EVALUATION OF NEW QUINOLINE DERIVATIVES AS A POTENT ANTI-INFLAMMATORY ACTIVITY ICLTIPB/PH/2023/1074 1 1 1,2 3 Arshi Atiya , Abhinav P. Mishra , Preeti Verma , Kuldeep Singh 1 Advance Institute Of Biotech And Paramedical Sciences, Kanpur, U.P. 208021. 2 Adarsh Vijendra Institute of Pharmaceutical Sciences Shobhit University Gangoh, Saharanpur U.P India. 3 Department Of Pharmaceutical Chemistry, SD College Of Pharmacy & Vocational Studies, Muzaffarnagar, U.P 251001. [email protected] Abstract: Liposomes are self-assembled structures that contain an internal water chamber surrounded by a lipid bilayer. This unique structure provides liposomes with a powerful ability to encapsulate hydrophilic, hydrophobic, amphiphilic, and nanoparticle molecules. Therefore, liposomes are often used as carriers of chemicals, biomolecules, and nanoparticles in drug delivery, chemical sensors, and biosensors. Liposomes combined with effective transduction techniques such as fluorescence and spectroscopy can achieve huge signal amplification and ultra-sensitive detection. Hydrogels are cross-linked in a three-dimensional arrangement with the advantage of having a porosity in the gel matrix that allows the loading of hydrophilic or hydrophobic drugs. They have high water content, bio-adhesive nature, high biocompatibility, and are biodegradable, le and form deposits from which drugs slowly elute into surrounding tissues, maintaining a high local concentration over a long period. Thus, baclofen loaded liposomal hydrogel could be promising in enhancing the topical drug absorption, and increasing drug bioavailability compared to the other gel formulation. Topically administration of baclofen reduces the dose due to the onsite delivery of muscle relaxant baclofen. Keywords:Baclofen, Hydrogel, Liposome FORMULATION AND EVALUATION OF BACLOFEN LOADED LIPOSOMAL HYDROGEL ICLTIPB/PH/2023/1075 Sanjay Kumar Patel United Institute of Pharmacy Naini Prayagraj [email protected] Abstract: Breast cancer is most common malignancy in female. Invasive cancer arises due to alterations in the cellular level resulting in the outgrowth and spread of breast epithelial cells with immortal features and uncontrolled growth. In our study 1,3,4 as thiadiazole derivatives tethered with isoniazid are chosen as a ligand due to its wide biological activity targeted on the human epidermal growth factor receptor 2 (HER2). Inhibition of HER2 emerges action in controlling the breast cancer. Based on these molecular docking study has been performed with twenty 1,3,4 thiadiazole derivatives as ligands were docked with HER2 receptor (PDB: 7PCD) using AutoDock vina. By using SwissADME the pharmacokinetic properties were obtained. On the basis of docking scores, the ligands scores (-8.7 to -10.2 Kcal/mol) were compared with INH (-5.2 Kcal/mol). Among these substitution with isopropyl, 2 chloro 5 nitro and 3,5 dinitro compounds shown best binding affinity with the score -10.2 Kcal/mol, all the ligands obeyed Lipinski's rule of five. The report has concluded 1,3,4 thiadiazole derivatives tethered with INH are capable of binding with HER2 receptor and downregulates its activity, to confirm the activity further studies can be done. The ADME analysis helped to determining its efficacy and toxicity. Keywords: Breast Cancer, HER2, Isoniazid, 7PCD, 1,3,4 thiadiazol. IN SILICO STUDY ON 1,3,4 THIADIAZOLE DERIVATIVES TETHERED WITH ISONIAZID ON HER2 FOR ANTI BREAST CANCER ACTIVITY ICLTIPB/PH/2023/176 Brundha S N, B V Suma Department of Pharmaceutical Chemistry, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Bangalore- 560054 [email protected]

75 Souvenir Souvenir 76 Abstract: The present study endeavoured to take advantage of nanotech approach (i.e nanoemulsion) as a novel green, environmentally friendly technique, for carotenoids extraction. Lutein is widely known for its antioxidant activities, free radical scavenging, anticancer, antiinflammatory properties, and neuroprotective effects. It is very susceptible to external stresses such as heat and light. Current research was carried out to develop novel nanoemulsion for simultaneous extraction and stabilization of carotenoids. 0.5 gm of dried marigold petals were added to 25mL nanoemulsion system, sonicated for 30 min. and kept for 12 hours. After 12 hours the mixture was again sonicated and centrifuged at 10,000 rpm for 20 min. Supernatant was removed and analyzed for lutein content. Lutein is extracted using acetone and lutein extracted solvent were added in nanoemulsion. Then solvent is evaporated to obtain lutein extracted nano-emultion. Analysis of lutein content in nanoemulsion performed using UV spectrophotometry and FTIR. Particle size of nano-globules dispersed in water is measured using DLS particle size analysis found to be 33.06 nm. These findings proved the capability of nanoemulsion technique as a potential alternative to conventional formulations for carotenoids and other industrial plant based bio compounds. Keywords:Nanotech; Lutein; rpm; FTIR. NANO EMULSION BASED CAROTENOIDS EXTRACTION ICLTIPB/PH/2023/1077 Swanand Kulkarni, Harshal Pisal, Aparna Bhalerao JSPM's Charak College of Pharmacy and Research,Wagholi, Pune, Maharashtra, India [email protected] Abstract: For the analysis of eugenol from a methanolic extract of Myristica fragrans seed, a sensitive, selective, accurate, and stability-indicating high-performance thin layer chromatographic method (HPTLC) was created and validated. With the binary mobile phase toluene-ethyl acetate-formic acid (1:5:0.2, v/v/v), chromatography was carried out on aluminium foil-backed silica gel 60 F-254 HPTLC plates. Densitometric analysis was done using a TLC scanner (CAMAG) at 560 nm in reflectance/absorbance mode. In accordance with ICH recommendations, the method was validated for precision, recovery, robustness, specificity, and detection and quantification limits. In the concentration range of 100-1000 ng band-1, the linear regression data for the calibration plots demonstrated a good linear relationship with r2 = 0.998. It was discovered that the system produced compact eugenol spots (Rf 0.55). The precision of 1.85% and 1.71%, recovery of 99.3–99.8%, and limits of detection and quantification of 21 and 63 ng band-1 were satisfactory. Eugenol forced to undergo dry heat treatment, oxidation, and photo-degradation. Additionally, the pure eugenol was clearly distinguished from the degraded products. Eugenol and its degradation products could be successfully separated using the method, making it useful as a stability indicator. This technique provided good resolution from other extract constituents that were present. The technique has been used to analyse and regularly check the quality of herbal material and formulations containing Myristica fragrans with success. Keywords: Myristica fragrans, eugenol, HPTLC, validation, stress degradation, recovery, robustness. TO ESTIMATE EUGENOL IN PURE AND MYRISTICA FRAGRANS SEED EXTRACT, A FORCED DEGRADATION STUDY USING THE HPTLC METHOD WAS CONDUCTED ICLTIPB/PH/2023/1078 Nikita Panwar, Mohamad Taleuzzaman, Ziyaul Haque Faculty of Pharmacy, Maulana Azad University, Jodhpur [email protected] Abstract: Quercetin, a naturally occurring flavonoid, has been shown to exhibit various pharmacological activities such as antioxidant, anti-inflammatory, wound healing and skin protective properties. However, its poor solubility and low skin penetration limit its therapeutic efficacy when applied topically. To overcome these challenges, Quercetin-loaded topical nano-formulations have been developed as a promising approach to enhance its therapeutic potential. Among various perspectives, a nanoparticles-based drug delivery system has received special attention and demonstrated numerous advantages in topical delivery of a hydrophobic drug such as quercetin. This systematic review aims to summarize the recent progress in the development of Quercetin-loaded topical nano-formulations and their therapeutic potential in diseases such as dermatitis, psoriasis, skin cancer, and skin fungal infections. The review summarizes, a variety of nanocarrier systems, such as nanovesicles, nanospheres, nanocapsules, nanogels, nanofibres, nanoemulsions, micelles, gold nanoparticles, silica nanoparticles, solid lipid nanoparticles (SLNs), and nanostructured lipid carriers (NLCs), have been created for the delivery of quercetin through the skin and their impact on Quercetin skin permeation and efficacy. Furthermore, the review highlights the in vitro and in vivo efficacy of Quercetin-loaded topical nano-formulations and their potential to overcome the limitations of conventional Quercetin formulations. The review concludes that Quercetin-loaded topical nano-formulations hold great promise as a therapeutic approach in skin diseases, and their further development and optimization are necessary to fully realize their therapeutic potential. Keywords:Quercetin, Nano-formulation, Topical, Disease. THERAPEUTIC POTENTIAL OF QUERCETIN LOADED TOPICAL NANO-FORMULATIONS: A SYSTEMATIC REVIEW ICLTIPB/PH/2023/1079 Zarnain Fatima, Afeefa, Chitra Gupta, Lloyd Institute of Management and Technology, Greater Noida, Uttar Pradesh, India [email protected] Abstract: The goal of the current work was to formulate and evaluate polymeric nanoparticles of Etizolam employing polymers Eudragit L100 and Chitosan by Nano precipitation method. Particle size, polydispersity index, entrapment efficiency (EE), zeta potential, solubility, morphological examination, in vitro study were carried to characterize the nanoparticles. The concept of this formulation provides the drug delivery system with enhanced bioavailability and sustained release action. The formulations were optimized employing central composite design by State Ease Design Expert software Version 13. These formulations deliver the drug through oral mucosa and bypass the first pass metabolism thereby increase bioavailability. There was no interaction between the drug excipients, according to infrared studies. Zeta potential readings below zero indicated that the formulated nanoparticles had been stabilised effectively. The entrapment efficiency was found to be in between 29.72 ± 3.27% – 63.95 ± 3.50%. The in-vitro drug release was extended maximum up to 12 hrs with Eudragit L100. The curve fitting data shows that the drug release followed first order kinetics, Higuchi's plots stated non-fickian diffusion controlled. SEM shows that nanoparticles were found spherical in structure without aggregation and uniform distribution of the drug within the nanoparticles. Keywords: Polymeric Nanoparticles, Etizolam, Nano precipitation method, bioavailability. FORMULATION AND EVALUATION ETIZOLAM LOADED POLYMERIC NANOPARTICLES IN TREATMENT OF ANXIETY DISORDERS: RESEARCH ICLTIPB/PH/2023/1080 Awate Pravin, Mahesh Kumar Gupta Career Point University, School of Pharmacy, Kota Rajasthan National Highway 52, Opp Alaniya Mata Ji Mandir, Alaniya, Kota, Rajasthan 325003. [email protected]

77 Souvenir Souvenir 78 Abstract: 3D printing or additive fabrication, is the creation of a threedimensional structure from a computer aided design (CAD) model or digital 3D model. In the form of liquid or powdered plastic, the 3D printing process works by laying down thin layers of plastic, metal or cement and then fusing the layers with objects. A variety of printing materials including plastics, powders, filaments and paper may be used to produce the item. In the pharmaceutical industry, a range of 3D printing technologies are available. 3D printing technology is used for mass customization, development of all forms of open-source designs in the fields of agriculture, healthcare, aviation industries. The development of 3D printing technology has set up new horizons in designing and producing printed materials and products. In this way the drug production will potentiatially lead to the likelihood of becoming a reality for personalised medicines. Using layer deposition of material directly from a CAD model, 3D printing technology can print an object layer. 3D printing has wide range of applications in the medical field such as tissue design, organ painting, diagnostics, biomedical device manufacturing, drug and delivery systems design. There as various key benefits of 3D printing technology are in the manufacturing of small batches of pharmaceutical products. Different techniques can be used to produce according to the needs of the patients, complex anatomical and medical systems such as computed tomography (CT) scanning and magnetic resonance imaging (MRI). This chapter offers an overview of the forms of 3D printing technology, applications and essentially, the materials used for 3D printing technology in the pharmaceutical industry. Keywords:3D Printing, CAD, medicines, MRI, CT. 3-D PRINTING: INNOVATIVE ASPECTS IN PHARMACEUTICALS INDUSTRY ICLTIPB/PH/2023/1081 Mann Parvinder, Rao Neha Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra [email protected] Abstract: Diabetes or Diabetes mellitus is a metabolic disease in which sugar levels are increased in the body for a prolonged period which produces many symptoms; frequent urination, increased thirst, hunger, diabetic ketoacidosis (DKA), and hyperosmolar coma. The long-term complications include; kidney failure, diabetic heart disease, stroke, foot ulcers, and damage to the vision of the eyes. Diabetes is due to not sufficient insulin produced by the pancreatic cells or the cells of the body do not respond properly to the insulin produced. This form is known as ''non-insulin-dependent diabetes mellitus'' (NIDDM) or ''adult-onset diabetes''. The primary cause of this diabetes is excessive body weight and not enough physical activity. Herbal drugs are proven to be a better choice over synthetic drugs because of fewer side effects and adverse effects. These are natural and safe drugs i.e., there are no toxic effects. Herbal drugs permanently cure a person and treat the disease while synthetic drugs are not permanently cured the disease. Herbal formulations contain natural herbs and fruits and vegetables extract which are beneficial in the treatment of various diseases without any adverse effects. On the other hand, chemical drugs are prepared synthetically and have side effects also. Herbal formulations are cheap compared to allopathic medicines. Herbal formulations are Eco friendly Phytochemicals are demonstrated to have antioxidant abilities not only in invitro but in human studies. Antioxidant phytochemicals could play an important role in the prevention and treatment of chronic diseases like Diabetes mellitus. Raphanus sativus belongs to the family Brassicaceae and contains chemical compounds of the poor water-soluble category like -Alkaloids, Coumarins, and some more chemical compounds Polysaccharides, Phenolic compounds, Organic acids, Vitamins, Sulphur compounds, etc. have a few to more active constituents which have antidiabetic properties. Although there are a lot of natural drugs which show antidiabetic properties still they do not fulfill the whole requirements of treatment of diabetes disorder. Keywords: diabetic ketoacidosis, herbal drugs, alkaloids. PREPARATION AND IN-VITRO ANTIDIABETIC EVALUATION OF RAPHANUS SATIVUS EXTRACT-LOADED NANOPARTICLES ICLTIPB/PH/2023/1082 Pavan Kumar Yadav United Institute of Pharmacy [email protected] Abstract: The majority of individuals spend 80–90% of their time indoors, including in their homes, offices, schools, gyms, and modes of transportation. Modern furnishings and high-tech equipment are placed in energy-efficient buildings that release hundreds of volatile organic compounds that may interact with one another. A poor indoor air quality may increase in the incidence of numerous forms of modern diseases or in modern term it called as 'sick building syndrome'. Literature review from various databases like Scopus, impact factor journal and Web of Science. Based on Abstract: Uterine fibroids (UFs), commonly known as leiomyomas or myomas, are a type of malignancy that affects the smooth muscle of the uterus. It is most commonly detected in women of reproductive age. Uterine fibroids are benign monoclonal growths that emerge from uterine smooth muscle cells (myometrium) as well as fibroblasts. Symptoms of Uterine fibroid include abnormal menstrual bleeding, tiredness, chronic vaginal discharge, and pain during periods. It is also associated with reproductive issues like impaired fertility, conceiving complications, and adverse obstetric outcomes. Twenty-five percent of the reproductive women experience the symptoms of uterine fibroids, and among them, around 25% require hospitalization due to the severity of the disease. The diagnosis and management of uterine fibroids are evolving rapidly with the goal to provide better, less invasive research over the last 30 years, this paper reviews the state of the art of plant systems and how they affect indoor environmental quality (IEQ). These indoor plants have a special ability to filter the air owing to natural systems. Some plants have the capacity to absorb, degrade, or transform harmful air pollutants into less harmful ones. The key points about indoor air pollution are outlined in this article, along with evidence for the effectiveness of indoor plants as an alternate method of remediating indoor air. Keywords: Volatile Organic Compounds, Indoor Air Quality, Air Filtration, Indoor Environmental Quality. treatments that improve quality of life and also address the underlying causes of fibroids. The uterine fibroid treatment included pain killers, supplementation with iron, vitamins, hormone therapy, gonadotropin-releasing hormone (GnRH) agonists, drugs modulating the estrogen receptors, and surgical removal of the fibroids. The diagnosis and management of uterine fibroids have undergone significant changes. Recently, minimally invasive techniques such as laparoscopic and hysteroscopic procedures have gained popularity. Newer measures such as uterine artery embolization and focused ultrasound ablation procedures are showing promise as potential treatments for fibroids. In the future, the development of new diagnostic and therapeutic technologies, such as gene editing and regenerative medicine that holds the potential to transform the management of uterine fibroids. Keywords:Uterine fibroids, myometrium, GnRH, fibroids. POTENTIAL USE OF INDOOR PLANTS TO AMELIORATE INDOOR AIR QUALITY: AN OVERVIEW CURRENT TRENDS AND FUTURE STRATEGIES IN THE DIAGNOSIS & MANAGEMENT OF UTERINE FIBROIDS ICLTIPB/PH/2023/1083 ICLTIPB/PH/2023/1084 Snehal S. Manekar, Prashant V. Ajmire Dr. Rajendra Gode Institute of Pharmacy, Amravati, Maharashtra, India. [email protected] 1 1* 2 3 Azaz Ahmad , Mohammad Ahmad , Nihar Ranjan Bhoi , Manoj Kumar 1 Department of Pharmacy, Integral University, Kursi Road, Lucknow-226026, India 2 Department of Clinical Research, Indira Fertility Academy, Udaipur-313001, India 3 Department of Clinical Research, Indira Fertility Academy, Udaipur-313001, India [email protected]

79 Souvenir Souvenir 80 Abstract: The present study was carried out to evaluate the antidiabetic and antioxidant activity of methanolic extract of plant leaves of Achyranthes aspera and Phaseolus vulgaris Linn. Methanolic Extract of leaves of plant Achyranthes aspera and Phaseolus vulgaris Linn are a highly rich plant in various components such as flavonoids, triterpenes, pregnanes, cardenolides, cardiac glycosides, and carbohydrate. 5-O-caffeoyl quinic acid which was isolated from the active fraction of leaves of Achyranthes aspera and Phaseolus vulgaris Linn and exhibited the potent antioxidant activity towards DPPH free radical. For these methanolic extract of leaves, the IC50 for DPPH radical scavenging was 81.53 ± 0.62 and 73.43 ± 0.42%. The ABTS test yielded results of 1432.06 ± 20.41 and 1342.06 ± 17.25µM TEAC/mg DW for the leaves. Glibenclamide (7 mg/kg) and methanolic extract of MEDH + MEPV (200 mg and 400 mg/kg) restored cholesterol Abstract: Thereincludesdiscussionofthetheories,methodologies,and applications of pharmacoeconomics and pharmaceutical outcomes evaluations. Pharmacoeconomics is the study of how to balance the price of pharmacological treatments and services with their effects (outcomes). Pharmacoeconomics, a sort of outcomes evaluation, considers a pharmaceutical's influence on overall health resource consumption and expenditures in addition to merely its direct or acquisition cost. This subfield of health care economics provides critical information for managing limited health care resources and medical practise. Health economics, and in particular and triglyceride levels to near normal in rats. The combination treatment of Achyranthes aspera and Phaseolus vulgaris Linn in a 1: 1 ratio for seven days in rats given alloxin-induced possibly lowers fasting blood glucose levels and improves pancreatic -cells considerably. Furthermore, the lipid profile was within normal norms. After a single dose of oral administration, an Achyranthes aspera and Phaseolus vulgaris Linn combination of up to 500mg/kg BW was shown to be safe. Achyranthes aspera and Phaseolus vulgaris Linn can be combined to create a safe anti-diabetic agent. As a result, more research is needed to investigate the changes in the Achyranthes aspera and Phaseolus vulgaris Linn dosage ratio and the antidiabetic mechanism of action of this combination. Keywords: antidiabetic, Achyranthes aspera, DPPH, dosage ratio. pharmacoeconomic studies, are increasingly being employed as a criteria for decision- making in contemporary health care policy as a result of limited financial resources. This article's goal is to introduce pharmacoeconomics, describe its various evaluation techniques, including cost minimization analysis, cost benefit analysis, cost utility analysis, cost effectiveness analysis, and guidelines for providing high-quality care at a reasonable cost. It will also discuss its challenges, restrictions & potential applications. Keywords: Pharmacoeconomics, cost, financial resource, cost benefit analysis. PHARMACOLOGICAL STUDY ON ANTIDIABETIC AND ANTIOXIDANT ACTIVITY OF METHANOLIC EXTRACT OF LEAVES OF ACHYRANTHES ASPERA AND PHASEOLUS VULGARIS LINN. A TOOL FOR EVALUATING THE ECONOMIC IMPACT OF DRUG THERAPIES: PHARMACOECONOMICS ICLTIPB/PH/2023/1085 ICLTIPB/PH/2023/1086 1 Sachin Kumar Agrahari*, Dr.(Prof.) M.K. Gupta , Jitendra Kumar, Dr. Mithilesh Dwivedee * Department of Pharmacology, K. J. College of Pharmacy, Varanasi, U.P. 1 Career Point University, Kota, Rajasthan [email protected] 1 2* Akanksha Pandey , Ashutosh Singh 1 Advance institute of biotech & paramedical sciences, Kanpur (UP) 2 SHEAT college of pharmacy, Varanasi (UP) [email protected] Abstract: Robot-assisted neurorehabilitation is a type of physical or occupational treatment that trains or retrains the brain on how to move a limb that is compromised due to an acquired neurological condition, such as a stroke, or a developmental motor disability, such as cerebral palsy. Purposeful activity and task-specific training that takes into account each patient's abilities and demands have been found to enhance motor function in children with sensorimotor impairments (Valvano 2004; Michmizos, Rossi, et al., 2015). To review the effectiveness of robotic technology in pediatric neurorehabilitation. We looked at ten to fifteen papers from PubMed, Google Scholar, and research gate that were Abstract: The abstract presents a successful approach that allows synthesizing and partial characterization of a novel class of potential anticancer agents, which are acetylenehexacarbonyl dicobalt complexes. The synthesis involves two steps: In first step synthesis of respective alkyne ligand was done by esterification of carboxylic acid with alcohol, in presence of 1, 3-Dicyclohexylcarbodiimide as activator and 4-Dimethylaminopyridine as a catalyst. In categorized as pediatric neurorehabilitation, robotic technology, and Pedi ankle boot a back-driveable, impedance-controlled, low-friction robotic device, 6-MWT is used to measure distance, while the time-up-and-go test is used to measure mobility and balance that trains the ankle of children with neurological impairments between 2015 and 2021. The therapeutic goals of paediAnklebot were functional walking and distinct ankle motions. PaediAnklebot is a robotic device that aids in children's rehabilitation and can accurately monitor kinematic and kinetic performance. Keywords:Robot, stroke, PubMed, Pedi ankle. second step, the alkyne ligand formed in first step was then stirred with Co2(CO)8 to give the respective cobalt complex by coordination. Partial characterization of these compounds using IR, NMR, GC-MS and TLC was performed. The project reports successful synthesis of few cobalt complexes, though failed to achieve them in a very pure form. Keywords: anticancer agents, esterification, IR, NMR, cobalt complexes. ROBOTIC TECHNOLOGY IN PAEDIATRIC NEUROREHABILITATION ANALYSIS OF ACETYLENEHEXACARBONYLDICOBALT COMPLEXES AS A POTENTIAL ANTI-CANCER AGENT THROUGH IR, NMR AND GC-MS TECHNIQUES ICLTIPB/PH/2023/1087 ICLTIPB/PH/2023/1088 Harshita Mittal, Kanchan Kholiya Department of Physiotherapy, Career Point University, Kota [email protected] Rahul Arun Jagtap, Dr. Meenakshi Bharkatiya 'Bhupal Nobles' Institute of Pharmaceutical Sciences B.N. University, Udaipur (Raj)-313001. [email protected]

81 Souvenir Souvenir 82 Abstract: RP HPLC method has been developed for the detection of Anidulafungin and to separate its related compounds. Anidulafungin was separated on a Zodiac C18 (150 × 4.6mm × 3.6µm) analytical column. The solvent system used for assay was Trifluoroacetic acid buffer: Acetonitrile (52:48 %v/v) of pH 4.7 at 1.5 ml/min flow rate and the detection at 300nm wavelength. The solvent system used for related compounds separation was phosphate buffer as Mobile phase A and Acetonitrile as Mobile phase B at 0.8 ml/min flow and the detection at 220nm wavelength and injection volume of 50 µL whose elution is gradient. The method has been validated according to the ICH guidelines for linearity, accuracy, limit of detection, limit of quantification, solution stability and robustness. The linear regression coefficient was found to be 1.000 with slope of 28225.77 and intercept is 35762.79. The accuracy was determined by a three different level recovery study and the mean % recovery was 101.0-101.5 which is within the specified limits. LOD and LOQ values were found to be 0.083 and 0.250ppm, respectively. The method developed was robust, simple and accurate. It is therefore appropriate for routine analysis. Keywords:RP HPLC, Zodiac, ICH, LOD, LOQ. ESTIMATION OF ANIDULAFUNGIN AND RELATED COMPOUNDS IN INTRAVENOUS DOSAGE FORM BY RP-HPLC METHOD ICLTIPB/PH/2023/1089 1 1 2 Ruchi Verma , Chebrolu. Sai Tejasvini , Sriramchandra Sekhar 1 Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Karnataka, India. 2 Head of Analytical Development, Celon Labs Pvt.Ltd, Aleap Industrial Estates, Kukatpally, Hyderabad, India [email protected] Abstract: HIV infection is responsible for many neurological problems, mainly AIDS dementia complex (ADC) which affects motor dysfunction that is responsible for NeuroAIDS. Antiretroviral (ARV) medications are in high demand for the treatment of NeuroAIDS. The primary issue with several (ARVs) is, they have low oral bioavailability which is mostly caused by their significant first-pass metabolism and poor water solubility. This study's objective is to create an ARVloaded nanoemulsion for improved NeuroAIDS care. For optimization of nanoemulsion, design expert software was used in which twenty runs were generated with three independent variables Oil (%), Smix (%), and sonication time (second), and four dependent variables with droplet size (nm), PDI, zeta potential (mV), and transmittance (%). Dependent variables had different constraints such as droplet size, PDI was minimum and zeta potential, and transmittance was maximum. For the selection of Smix ratio, pseudoternary phase diagram data was studied in which different ratios of Smix were used 1:0, 1:1, 2:1, 3:1, 4:1, 5:1and 1:2 containing tween 40 and polyethylene glycol 400 as surfactant and cosurfactant respectively and oil in ratio 9:1, 8:2, 7:3, 6:4, and 5:5 and concluded for 4:1 as Smix ratio. The droplets of the optimized nanoemulsion were spherical and had a globule-like shape with no aggregation, as shown by surface morphology as determined by TEM. The optimized nanoemulsion's particle size, zeta potential, conductivity, and percent transmittance were investigated. The result of the observed response for the formulation was found to the predicted response. Keywords:HIV, Neuro AIDS, Oil, PDI, zeta potential. NANOEMULSION FOR THE MANAGEMENT OF NEUROAIDS BY ARV THERAPY: DEVELOPMENT AND EVALUATION ICLTIPB/PH/2023/1090 Verma Kunal, Dr. Kumar Shobhit Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology (MIET) NH-58, Delhi-Roorkee Highway, Meerut-250005, Uttar Pradesh, India. [email protected] Abstract: Due to modernized dietary life style, Renal calculi are common with high prevalence rate. The etiology is multifactorial and the recurrence rate is high. So far there is no permanent cure for renal calculi. The leaf decoction of Kalanchoe gastonis-bonnieri is prescribed against renal calculi by traditional practioners. In this research the traditional dosage form, leaf decoction of Kalanchoe gastonis-bonnieri against renal calculi is modernized into o/w nanoemulsion. In addition, the plant drug is subjected for DNA authentication studies using ITS as universal marker. The leaves are subjected for extraction process by continuous hot percolation method using n-Hexane and Hydroalcohol 70%. The solvent free extracts 0.1% is subjected for formulating o/w nanoemul s ion by High- speed homogenization method under 10,000rpm for 1 hour using 1% Abstract: Peptic ulcer disease is a chronic condition that affects the gastrointestinal (GI) tract or digestive system. Peptic ulcer causes soreness or lesions in the mucous of the stomach and first part of the small intestine (duodenum). The most common cause of peptic ulcer disease are imbalance between Aggressive and defensive/protective factors at normal physiological state of stomach. The most common aggressive factors includes Pepsin, gastric acid secretions, prolonged use of NSAID's, ethanol consumption, H.pylori bacterial infections, secondary life style, and defensive/protective factors include bi-carbonate secretion, Gastric mucous, Prostaglandins, high mucosal blood flow etc. symptomatic features of peptic ulcer disease shown by burning pain in the upper center of the abdomen, loss of appetite, epigastric burning or aching pain(Heart burn) pain worse at night & 1-3 hrs after meals,vomiting, bloating, belching & weight loss etc. the genus Ficus (Moraceae) constitutes one of the largest genera of angiosperms includes with more than 800 species and 2000 varieties of ficus genus, occurring in most of tropical and tween 80 and 1% span 20 as surfactant and co-surfactant. The n a n o e m u l s i o n i s s u b j e c te d fo r Phys i c o c h e m i c a l Characterization. The leaf drug is subjected for DNA authentication studies. Plant genome is isolated by CTAB method and further sequenced using ITS marker. The particle size of oil globules is found to be 154.4 d. nm and the PDI is 0.261. In DNA authentication studies kalanchoe gastonis bonnieri placed separately showed genetic variation among the various species of Kalanchoe. Modernizing the traditional dosage form into nanodosage form and authenticating the plant in genomic level is done hence new trends in herbal technology and nanotechnology is the need of the hour in drug discovery process. Keywords:HIV, Neuro AIDS, Oil, PDI, zeta potential. subtropical forests worldwide. For this study Ficus auriculata Lour (Family: Moraceae) species were collected from various locations from Kumaun region of Uttarakhand. Methanolic leafs extract of Ficus auriculata was assessed for its anti-ulcer activity in animals (wistar albino rats). the antiulcer activity was evaluated by using three in-vivo models. In which experimental animals were divided into 4groups (6 animals in each group) for all three-model net 72 animals are used, all animals are fasted overnight with water as libetum before 18-24 hrs. Prior to experiment and kept individually into a cylindrical stainlesssteel cage to limit their mobility and coprophagy. Pylorus ligation induced gastric ulcer in this ulceration is caused by minor surgery of pylorus ligation in presence of monitored dose of ketamine, then dose of normal control 0.9%Nacl, omeprazole (20mg/kg body wt.) and leafs extract at low (200mg/kg b.w) and high dose (400mg/kg body wt.). after that animal was kept on observation for 8-18hrs. Later that animal was to be sacrificed by overdosing of ketamine anaesthesia. Keywords: Ficus auriculata; anti ulcer activity; phytochemical screening; indomethacin; ethanol. DESIGN, DEVELOPMENT AND CHARACTERIZATION OF KALANCHOE GASTONIS BONNIERI (CRASSULACEAE) INCLUDING DNA AUTHENTICATION STUDIES PHARMACOLOGICAL EVALUATION OF LEAFS EXTRACT OF FICUS AURICULATALOUR FOR ANTI ULCER ACTIVITY ICLTIPB/PH/2023/1091 ICLTIPB/PH/2023/1092 Selvakumari. E, Arun Kumar. M, MuthuKumaran, R College of Pharmacy, Mother Theresa Post Graduate & Research Institute of Health Sciences (A Govt. of Puducherry Institution), Puducherry-605006, India. [email protected] Deepak Chandra Joshi, Department of Pharmacy, Invertis University, Bareilly, Uttar Pradesh, INDIA. [email protected]

83 Souvenir Souvenir 84 Abstract: In the current research, we envisaged the synthesis of dihydroisoxazole ring by [3+2] cycloaddition of VEC (vinyl ethylene carbonate) and Nitrile oxide, assisted byPdcatalyst. Herein we explored the hydroximoyl chlorides as versatile precursors for thein situ generations of nitrile oxides that were exploited to achievecycloadditionreaction on a vinyl group of VEC to generate bis-heterocycles. in silico-based studies of bis-heterocycles on cyclooxygenase (COX) enzyme displayed selective COX-2inhibition. Keywords: - COX-2 inhibitors, in silico, heterocyclic ring, α, β-unsaturated amides. PD-CATALYSED [3+2]-CYCLOADDITION TOWARDS THE GENERATION OF BIOACTIVEBIS-HETEROCYCLES/IDENTIFICATION OF COX-2 INHIBITORS VIA INSILICOANALYSIS ICLTIPB/PH/2023/1093 Elagandhula Sathish, Manmohan Sharma, Arshad J. Ansaria, Gaurav Joshic, Akansha Pandita, Monika Shukla, Neha Kumarie, Ashoke Sharon, Ved Prakash Verma, Devesh M. Sawant Nirma University, Ahmdabad, Gujarat [email protected] Abstract: Numerous herbal remedies of the Indian traditional healthcare system include plants that have been used medicinally for thousands of years, and there has been a great deal of study conducted over the last few decades to identify possible ingredients from plant sources. Amoora rohituka, one of the medicinal plants utilised for their therapeutic (active) impact in Ayurvedic Rasayana, has achieved a high profile and been extensively studied. It has long been revered as a medicinal herb in India and across Asia. The Meliaceae family is responsible for its development. Research on the plant was conducted in several countries due to concerns about the plant's possible therapeutic uses. In traditional medicine, it is used for a broad range of conditions, including as an antihelmentic, a hepatoprotective, an antibacterial, an antirheumatic, and a spleen tonic. This poster discusses the biological activities and specific medical applications of Amoora rohituka in great depth. The report also details the recent isolation of a variety of active chemicals, such as lipids, glycosides, and saponins. Keywords: Amoora rohituka, Ayurveda, Harin-Hara, Meliaceae, Phytochemistry, Medicinal use. PHYTOCHEMITRY, MEDICINAL USES ALONG WITH ITS BIOLOGICAL ACTIVITIES OF AMOORA ROHITUKA (MELIACEAE) LEAVES ICLTIPB/PH/2023/1094 Prateek Porwal, Dilip Kumar Chanchal, Gyan Singh Glocal School of Pharmacy, The Glocal University, Mirzapur Pole, Saharanpur - 247121, Uttar Pradesh, India. [email protected] Abstract: Biological synthesis is a cost-effective, non-toxic, and environmentally advantageous approach for producing nanoparticles. Utilizing botanical and microbial extracts that include pharmacologically important compounds, metal nanoparticles are reduced and stabilised. nickel, and iron in order to improve living standards, nanoparticles are commonly employed in a number of industries. As a result, there is an increasing need to develop ecologically responsible and responsible techniques of nanoparticle synthesis that don't involve hazardous chemicals. Physical, chemical, and biological processes can all be used to synthesise nanoparticles. The biological approach is the most effective of the bunch for maintaining and reducing metal ions. Biological synthesis is a cost-effective, nontoxic, and environmentally advantageous approach for Abstract: Huntington's disease is a progressive, autosomal dominant neurodegenerative disease which progressively effect brain cell entire over time lead to progressive loss of physical and cognitive abilities. The common pathological cascade of Huntington's disease (HD)is transcription dysregulation, mitochondrial dysfunction, excitotoxicity, dysfunctional synapses, and oxidative stress. This study was conducted to investigate the beneficial role of Flavonoid (naringin) on 3 NPA induced neurotoxicity in HD experimental rat model. 3 NPA (10 mg/kg body weight (b.w.) was administered intraperitoneally (i.p.) for 21 days. Naringin was administered orally (20, 50 and 100 mg/kg b.w.) with i.p. administration of 3 NPA. One additional standard drug (NMDA antagonist) is also administered as control d r u g . Bo d y we i g h t a n d b e h a v i o u r a l p a r a m e t e r s (Actophotometer, rotarod, open field, grip strength and narrow beam activity) were assessed on the 0, 1st, 7th, and 21st day post-3-NP administration. Lipid peroxidase, nitrite producing nanoparticles. Botanical and microbial extracts are used to decrease and stabilise metal nanoparticles, including. Green synthesis also has advantages in terms of accessibility, nontoxicity, cost efficiency, and handling simplicity. Photochemical and electrochemical processes, which need a lot of energy, pressure, and heat, are used in the chemical process. As a result, we also selected a technique for generating nanoparticles from the latex of the calotropis procera plant. Along with that, FTIR, TEM, U.V. spectroscopy, and XRD analyses were used to assess the synthesised nanoparticles. We then spoke about whether the nanoparticles may be used for various purposes based on this. Keywords: cost-effective; nanoparticle; botanical extracts; XRD; FTIR. concentration, endogenous antioxidant enzymes (superoxide dismutase and catalase levels), Nrf2, mitochondrial enzyme complexes (1st, 2nd, and 4th), pro-inflammatory compounds (TNF-a, IL-6, NF-kB), and caspase-3 activity were measured on day 22 in the striatum. 3 NPA administration significantly reduced body weight, locomotor activity, oxidative defence, mitochondrial enzyme complex activities and increased TNF-a, IL-6, caspase-3 activity, and NF-kB levels in the striatum. Treatment with naringin attenuated the impairment in behavioural, biochemical, and mitochondrial, pro-inflammatory and pro-apoptotic markers as compared with vehicle-treated group. All these changes were supported by histopathological observations. These findings demonstrate that naringin exerts a neuroprotective effect against oxidative stress in 3 NPA induced HD rat model. Keywords : Na ringin, 3 NPA, Huntington di sea se, Neurodegeneration, Oxidative stress. SYNTHESIS OF IRON, NICKEL NANOPARTICLES FROM CALOTROPIS PROCERA LATEX AND ITS APPLICATIONS NEUROPROTECTIVE EFFECT OF FLAVONOID IN 3 NPA INDUCED EXPERIMENTAL ANIMAL MODEL OF HD PHENOTYPE VIA REGULATING NRF2/ NF-KB SIGNALING PATHWAY ICLTIPB/PH/2023/1095 ICLTIPB/PH/2023/1096 * Surinder kumar, Asha Kumari, Rahul Sharma * Department of chemistry, career point University, Bhoranj (Tikker, Kharwarian) Hamirpur, MDR 35, Himachal Pradesh 176041, India. [email protected] Afsha khan Meerut institute of engineering and technology, Meerut [email protected]

85 Souvenir Souvenir 86 Abstract: Coconut water is the clear liquid found inside immature coconuts (Cocos nucifera). As the coconut matures, the water is replaced by coconut meat. Coconut water is rich in electrolytes such as potassium, sodium, and magnesium etc. Because of these electrolytes, there's a lot of interest in using coconut water to treat and prevent dehydration.1 Coconut water is sometimes called green coconut water because the immature coconuts are green. Centuries ago, Polynesian, Melanesian and Micronesian mariners used coconut fruits as reserves of food and drink.2 For study the presence of various types of electrolytes in juice of Cocos nucifera different types of wet tests was performed in the laboratory. In which some common tests are as silver nitrate test, chromyl chloride test, copper chips tests and ammonium molybdate test etc. The pure sample of Cocos nucifera contains respective electrolytes chloride, nitrate, phosphate, dichromate, zinc, magnesium, potassium, calcium and sodium. Coconut water is not a common fruit juice. Its low acidity combined with well-balanced sugar content and isotonic mineral composition makes it a potential rehydration and sport drink. However, the quality of coconut water can not only be attributed to sugars and minerals because it also has a typical flavour and some original properties. Keywords: Coconut Water, Cocos nucifera, electrolytes, electrolytes, sugars. BENEFICIAL ELECTROLYTES PRESENT IN THE JUICE OF COCOS NUCIFERA ICLTIPB/PH/2023/1097 Ankita Agarwal Keral Verma Subharti College of Science, Swami Vivekanand Subharti University, Meerut, India [email protected] Abstract: Prostate cancer is a common type of cancer in males, but it is highly treatable in the early stages. As numerous Anticancer drugs are launched but possess different side effects, like decrease in the amount of urine, blood in the urine or stools, peeling, or loosening of the skin etc. To control Prostate cancer, new medications must be developed. To identify the ligands, correct binding geometry in the binding site. To predict the binding affinity of the ligands with active binding site. To predict the ADMET properties of designed compounds Molecular docking study of 2-mercapto benzimidazole analogues with Androgen receptor target was carried out so as to evaluate their theoretical binding affinities. The chemical structure of the molecules was accurately drawn using ChemDraw software, suitable 3D crystal structure of protein was downloaded from protein data bank and the docking operation was carried out using PyRx virtual screening Autodock vina software. The top 4 ligands were submitted to in silico ADMET analyses in Swiss ADME Webserver depending upon binding energy and amino acid interactions. Compounds 3 have a high binding affinity (-10.2) for the target. Drugs with strong gastrointestinal absorption, orally bioavailability, and low toxicity were predicted using in-silico ADMET and druglikeness prediction. The current investigation supports these compounds as potential lead prospects for the treatments of breast cancer, which may help medicinal chemists and pharmaceutical specialists in the future design and synthesis of more effective medication options. Keywords: Autodock vina, Binding affinity, Chemdraw, Molecular docking Pharmacokinetics, Pyrx, Swiss ADME. DESIGN OF NOVEL 2-MERCAPTOBENZIMIDAZOLE DERIVATIVES FOR THE TREATMENT OF PROSTATE CANCER: AN IN-SILICO APPROACH ICLTIPB/PH/2023/1098 1 1 Nayana J , B V Suma Department of pharmaceutical chemistry, faculty of pharmacy M.S. Ramaiah University of applied Sciences, Bangalore 560054 [email protected] Abstract: Breast cancer is the most serious type of cancer in which cells in the breast grow out of control. Despite the fact that numerous new anti-cancer medications have been launched, different side effects have been recorded, like darkening or redness of the skin, fast or irregular heartbeat, fever or chills, joint pain etc. To control breast cancer, new medications must be developed. Aims are to identify the ligands, correct binding geometry in the binding site, to predict the binding affinity of the ligands with active binding site, to predict the ADMET properties of designed compounds. Molecular docking study of 2-mercapto benzimidazole analogues with HER2 target was carried out so as to evaluate their theoretical binding affinities. The chemical structure of the molecules was accurately drawn using ChemDraw software, suitable 3D crystal structure of Abstract: Alzheimer's disease (AD) is a neurodegenerative disease that usually starts slowly and progressively worsens. The AD is a currently ranked as the 7th leading cause of death in the United States and is the most common cause of dementia. AD is a brain disorder that gets worse over time. It's characterized by changes in the brain that lead to deposits of certain proteins. It causes the brain to shrink and brain cells to eventually die. AD is the most common cause of dementia — a gradual decline in memory, thinking, behaviour and social skills. These changes affect a person's ability to function. About 6.5 million people in the United States age 65 and older live with Alzheimer's disease. Among them, more than 70% are 75 years old and older. Of the about 55 million people worldwide with dementia, 60% to 70% are estimated to have Alzheimer's disease. there are some common early symptoms that may appear some time before a diagnosis of dementia. These include: memory loss, difficulty concentrating, finding it hard to carry out familiar daily tasks, such as getting confused over the correct change when shopping, struggling to follow a conversation or find the right word, being confused about time and place, mood changes, eventually forget the names of family members and everyday protein was downloaded from protein data bank and the docking operation was carried out using PyRx virtual screening Autodock vina software. The top 5 ligands were submitted to in silico ADMET analyses in Swiss ADME Webserver depending upon binding energy and amino acid interactions. Compounds 6 have a high binding affinity (-9.4) for the target. Drugs with strong gastrointestinal absorption, orally bioavailability, and low toxicity were predicted using insilico ADMET and drug-likeness prediction. The current investigation supports these compounds as potential lead prospects for the treatments of breast cancer, which may help medicinal chemists and pharmaceutical specialists in the future design and synthesis of more effective medication options. Keywords: Autodock vina, Binding affinity, Chemdraw, Molecular docking Pharmacokinetics, Pyrx, Swiss ADME. objects. The exact causes of Alzheimer's disease aren't fully understood. But at a basic level, brain proteins fail to function as usual. This disrupts the work of brain cells, also called neurons, and triggers a series of events. The neurons become damaged and lose connections to each other. They eventually die. Alzheimer's disease is caused by a combination of genetic, lifestyle and environmental factors that affect the brain over time. Researchers trying to understand the cause of Alzheimer's disease are focused on the role of two proteins: a) Plaques. Beta-amyloid is a fragment of a larger protein. When these fragments clump together, they appear to have a toxic effect on neurons and to disrupt communication between brain cells. These clumps form larger deposits called amyloid plaques, which also include other cellular debris. b) Tangles. Tau proteins play a part in a brain cell's internal support and transport system to carry nutrients and other essential materials. In AD, tau proteins change shape and organize into structures called neurofibrillary tangles. The tangles disrupt the transport system and cause damage to cells. Keywords: Alzheimer's disease; brain disorder; genetic; Plaques; Tangles. IDENTIFICATION OF NOVEL 2-MERCAPTOBENZIMIDAZOLE DERIVATIVES FOR THE TREATMENT OF BREAST CANCER: A COMPUTATIONAL APPROACH SCIENTIFIC UPDATE ON ALZHEIMER'S DISEASE ICLTIPB/PH/2023/1099 ICLTIPB/PH/2023/10100 1 1 Nayana J , B V Suma Faculty of pharmacy, M. S. Ramaiah University of applied Sciences, Bangalore 560054 [email protected] Khushal Garg, Devender Pathak, Mayank Kulshreshtha Department of Pharmacology, Rajiv Academy for Pharmacy, Mathura (U.P.), India [email protected]

87 Souvenir Souvenir 88 Abstract: Nature has been a source of medicinal agents for thousands of years and an impressive number of modern drugs have been derived from natural sources, many of these isolations were based on the uses of the agents in traditional medicines. Oxidative stress is the major role involved in the etiology of depression. Reduced oxidative stress correlates with the antidepressant treatment and brings the moderate clinical recovery of depression. Natural antioxidants that are present in herbs and spices are responsible for inhibiting and preventing the deleterious consequences of oxidative stress. Different concentrations of Jasminum sambac were used to evaluate the antioxidant effect. Antioxidant screening methods such as DPPH assay, scavenging of nitric oxide and hydrogen peroxide were determined. The extraction was carried out by using different solvents viz., methanol, ethanol, ethyl acetate, chloroform, petroleum ether and aqueous extracts for phytochemical screening and methanol, ethanol, ethyl acetate and aqueous extracts for antioxidant analysis. Antioxidant assay was done by determining DPPH, ABTS and Chelating potential of flower extracts. Phytochemical screening of flower extracts revealed the presence of alkaloids, tannins, carbohydrates, sterols and terpenoids, flavonoids, cardiac glycosides, proteins and amino acids. The quantitative determination of total phenolic, total flavonoids and various antioxidant activities was carried out using colorimetric method and the results revealed that the total phenolic and total flavonoids were maximum in ethanol extract of flower. The antioxidant activity was expressed in terms of EC50 value and maximum reduction percentage was observed in ethanol extract of flower. Thus, the present research study added scientific evidence to the antioxidant potentiality of Jasminum sambac. Further formulations may be prepared and evaluated by in vivo studies. Keywords:Antioxidant, Jasminum sambac, DPPH. PHYTOCHEMICAL SCREENING AND IN VITRO AND IN VIVO ANTIOXIDANT POTENTIAL OF JASMINUM SAMBAC FLOWERS ICLTIPB/PH/2023/10101 Sushila Gupta, Bhupendra Chauhan, Mayank Kulshreshtha Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University,Saharanpur (UP), INDIA Rajiv Academy for Pharmacy, Mathura (U.P.), India. [email protected] Abstract: Myocardial infarction (MI), commonly known as a heart attack, occurs when blood flow decreases or stops to the coronary artery of the heart, causing damage to the heart muscle. In 2015, about 15.9 million myocardial infractions occurred throughout the world. In the United States about one million people have an MI each year. Symptoms of a heart attack or Myocardial infarction includes; chest pain, shortness of breath or trouble breathing, fatigue, trouble sleeping (Insomnia), sweating, anxiety, heart palpitations, nausea, feeling lightheaded, dizziness etc. The most common cause of a myocardial infarction is the rupture of an atherosclerotic plaque on an artery supplying heart muscle. Plaques can become unstable, rupture, and additionally promote the formation of a blood clot that blocks the artery; this can occur in minutes. Blockage of an artery can lead to tissue death in tissue being supplied by that artery. Risk factors- The most prominent risk factors for myocardial infarction are older age, actively smoking, high blood pressure, diabetes mellitus, and total cholesterol and highdensity lipoprotein levels. Many risk factors for myocardial infarction are potentially modifiable, with the most important being tobacco smoking (including second-hand smoke). Smoking appears to be the cause of about 36% and obesity the cause of 20% of coronary artery disease. Lack of physical activity has been linked to 7–12% of cases. After a heart attack, your doctor may recommend that you start taking medication to help reduce your risk of heart attack and improve cardiovascular function. These could include: Aspirin or anticoagulants (to prevent blood clots), Beta blockers, calcium channel blockers, or ACE inhibitors (to improve blood flow, slow the heart rate), Anti-diabetic medications (to control blood sugar), Statins (to reduce cholesterol), Beta blockers, ACE inhibitors, or diuretics (to reduce blood pressure), Nitrates (to reduce angina). Keywords: Myocardial infarction, plaque formation, aspirin, side effects. SCIENTIFIC UPDATE ON MYOCARDIAL INFARCTION ICLTIPB/PH/2023/10102 Yatin Kumar, Devender Pathak, Mayank Kulshreshtha Rajiv Academy for Pharmacy, Mathura (U.P.), India. [email protected] Abstract: The extract of R. acetose is used to treat gastritis, and has several biological activities, along with anti-ulcerogenic, anti-inflammatory, anti-proliferative and anti-viral. It is widely spread across eastern Asia and used in the treatment of different diseases. Leaves are used mixed with boiled potatoes to mitigate their acidity. It contains the amount of biologically active chemical combination of anthraquinones, flavonoids, and carbohydrates. The herbal and traditional remedies which form the role of addiction remedy possess convert in the favor of both developed and developing countries. Leaves are also found to study the analysis and infinitesimal particles, to find out the review variables such as ash values, extractive values, moisture content, and foreign matter. The appearance of several biomolecules inner one herb makes it tough to think about the whole plant as a remedy. Under histological evaluation, pretreatment with R. acetosa extracts reversed negative effects, such as inflammation, edema, moderate hemorrhaging and loss of epithelial cells, presented by HCl/ethanol-treated stomachs. Hyperin is an important flavonoid found in different parts of the plant was several pharmacological activities like antioxidants, anti-inflammatory, anticancer, antiviral, antiba c te ri a l , antipa r a s iti c, c a rdioprote c ti ve, hepatoprotective, and antispasmodic. Keywords: biologically, flavonoids, hyperin, beneficial, treatment, disease. PHARMACOGNOSTIC AND PHYTOCHEMICAL EVALUATION OF RUMEX ACETOSA ICLTIPB/PH/2023/10103 Anuradha, Manish Kumar MM College of Pharmacy, Maharishi Markandeshwar University, Mullana, Ambala. [email protected] Abstract: Shampoos are the major cleansing products used for hair treatment. Our objective is to embrace an approach to avoid synthetic hair products and focuses on herbal approach our scalp might be sensitive to chemicals. Herbal shampoos are already popular in the market so we have tried to bring something new to the market by approach herbal shampoo in the form of gel. Our chemical shampoo is formulated using extracts of bitter melon (Momordica charantia), Spinach leaves (Source of vitamin E), Shikakai (Acacia concinna), Honey, Gelatin and mentha oil by using maceration process of extraction. We have fomulated five batches (S1, S2, S3, S4, S5) of the mention ingredients, amongst which S4 showed an excellent response to the physical parameters like spreadability, centrifugation, pH analysis, viscosity, lather formation property etc. Besides this, further studies is still going on. Keywords: Herbal Shampoo, Synthetic Shampoo, Maceration process, Cleansing Products. HERBAL GEL SHAMPOO ENRICHED WITH EXTRACT OF BITTER MELON AND VITAMIN E ICLTIPB/PH/2023/10104 Akriti Yadav, Neha Singh Aditya College of Pharmacy, Satna (M.P.) [email protected]

89 Souvenir Souvenir 90 Abstract: Glycyrrhiza glabra which is commonly known as licorice contains the highest amount of glycyrrhizin content. Glycyrrhizin is a natural saponin glycoside that is the main active component obtained from the roots of glycyrrhiza glabra belonging to a family, Leguminosae. Literature survey shows determination of glycyrrhizin in the commercial formulation and glycyrrhiza glabra roots have been reported using HPTLC method. Analytical method was developed ad validated for the quantification of glycyrrhizin in glycyrrhiza glabra roots extract by High Performance Liquid Chromatography (HPLC). The Chromatographic separation was achieved on Zorbax extended C18 (250mm x 4.6mm, 5 µm) column. The separation achieved consisted of a mobile phase 0.1 % formic acid in water: ACN in gradient elution. The flowrate was 1 mL/min and UV detection at 250 nm. The average retention time of glycyrrhizin was found to be 7.30. The linearity level of concentration was found to be linear and all other validation parameters are within the acceptable range. Forced degradation studies was performed in acidic, basic, hydrogen peroxide and thermal degradation to check its stability and it was found that the degradants peak was observed in acidic conditions. To further identify and characterized the name of unknown impurity in acidic condition, a further study of advanced analytical technique LC-HRMS is suggested. However, since glycyrrhizin content is the major constituent in glycyrrhiza glabra extract, quantification was carried out to quantify how much content of glycyrrhizin present in the particular region that was collected. Keywords:LC-HRMS, HPTLC, UV. STABILITY- INDICATING METHOD DEVELOPMENT AND VALIDATION OF GLYCYRRHIZIN USING RP-HPLC-DAD: QUANTIFICATION OF GLYCYRRHIZIN IN GLYCYRRHIZA GLABRA EXTRACT ICLTIPB/PH/2023/10105 Waibiangki Lyngdoh Institute of Pharmacy, Assam Don Bosco University, Tapesia- 782402 [email protected] Abstract: The phytosome was formulated through solvent evaporation technique using n-hexane extract of Mesua ferrea Linn flowering buds (nMF), soya lecithin, and cholesterol (1:1:0.50; 1:2:0.75; 1:3:1) ratio. This formulated phytosome was evaluated by polydispersity index (PDI), particle size, zeta potential, entrapment efficiency, loading capacity and transmission electron microscopy (TEM). The TEM was used to observe the morphology of the prepared phytosome. The best optimized phytosome formulation was selected according to the evaluation parameter and then prepared phytosome-loaded n-hexane extract of flowering buds of Mesua ferrea Linn. Gel (MFPG), which was formulated by slowly dissolving Carbopol-934 in various concentrations (1.5%, 0.5%, and 1% of w/w) with distilled water to obtain a uniform dispersion. Triethanolamine (TEA) was then added and continuously stirred to produce a viscous clear gel. These phytosomal gels were evaluated by the organoleptic properties, pH and homogeneity, viscosity, spreadability, extrudability, syneresis, drug content, Fourier Transform Infrared Spectroscopy (FTIR), and stability study. Finally, the MFPG formulations were optimized by the ex-vivo skin permeability studies with Franz diffusion cell apparatus (50ml with 2.5cm diameter). For the ex-vivo permeation study, the goatskin (diameter 0.4mm) was collected from the slaughterhouse. The collected sample was diluted and tested by using an HPTLC study. Several mathematical models were used to perform the kinetic study. This MFPG formulation will be used topically and also produce a better therapeutic effect in the treatment of skin disease. Keywords: Phytosome, Mesua ferrea Linn, Phytosome loaded gel FORMULATION AND EVALUATION OF PHYTOSOME-LOADED N-HEXANE EXTRACT OF FLOWERING BUDS OF MESUA FERREA LINN. GEL ICLTIPB/PH/2023/10106 a* a Jugal Sutradhar , Bapi Ray Sarkar a Department of Pharmaceutical Technology, University of North Bengal, Raja Rammohunpur, Darjeeling, West Bengal- 734013, India [email protected] Abstract: Traditional medicines derived from medicinal plants are used by about 60% of theWorld's population. Ayurveda is the traditional system of medicine prevalent inIndia since 2000 B.C. After thorough study.Most of the herbal preparations are free from side effects or reactions. Herbal medicine provides rational means for the treatment of many internal diseaseswhichare considered to be obstinate and incurable in other system of medicines. The Anthelmintics activity of the Hydroachoholic extract of Nymphaea alba Flower was evaluated in vitro against earthworms, roundworms, and tapeworms at different concentrations such as 25, 50, and 100 mg/ml. The activity of Hydroachoholic extract as an in vitro anthelmintic was assessed using the technique. Because of their morphological and physiological resemblance to human intestinal roundworm parasites, the activity of anthelmintics was tested on adult Indian earthworms, roundworms, and tape worms taken from Indian pigs. Keywords: Nymphaea alba, Ayurveda, Nymphaeaceae, Phytochemistry, Medical uses. PHYTOCHEMISTRY, MEDICAL USES ALONG WITH ITS BIOLOGICAL ACTIVITY OF FLOWER OF NYMPHAEA ALBA (NYMPHAEACEAE) ICLTIPB/PH/2023/10107 *1 *2 Vinay Kumar Siroliya , Saurabh Savita Institute of Pharmacy, P K University, Vill-Thanra, Teh- Karera, Shivpuri, Madhya Pradesh, Pin-473660 [email protected] Abstract: TB occurs in every part of the world. In 2021 the largest no. Of new TB cases occurred in the WHO south east Asian region with 46% of new cases. 8 countries accounted for more than two thirds of the global total-India, Indonesia, china, Philippines, Pakistan, Nigeria, Bangladesh etc. Tuberculosis is caused by Mycobacterium tuberculosis that most often affect the lungs. TB mostly affects adults in their productive years. However, all age groups are at risk. Over 80% of cases &deaths are in low- & middle-income countries. In 2021-22, 0.74 million new TB cases worldwide were attributable to alcohol use disorder & 0.69 million were attributable to smoking. Drug susceptible to TB disease is treated with a standard 4 month or 6-month course of 4 antimicrobial drugs. India's TB incidence for the year 2021 is 210 per 100,000 population composed to the baseline years of 2015. There has been an 18% decline which is 7% points better than the global average of 11%. The TB programme 's nutrition support scheme - Ni-kshay poshan yojana- has proved critical for the vulnerable. In Sep 2022 launched a first of its kind initiative, Pradhan Mantri TB mukt Bharat Abhiyan to provide additional nutritional support to those on TB Treatment, through contributions from community including individuals & organizations. Till date 40,492 donors have come forward to support over 10,45,269 patients across the country. In 2021, M.P. data states 16,7018 people in public or private sector and 4149 peoples in Satna district diagnosed with TB. As follows with increasing rate in 2022 in M.P that 18, 5998 people's infected with TB and 4910 in Satna. WHO strategic priorities is to providing global leadership to end TB through strategy development, political & multispectral engagement including with civil society. Keywords: Tuberculosis, WHO, Drug susceptible, Bharat Abhiyan, Nikshay poshan yojana. A GENERAL CASE STUDY: HEALTHCARE DATA VISUALIZATION ON TUBERCULOSIS IN M.P. (DISTRICT- SATNA) ICLTIPB/PH/2023/10108 Bharat Lal, Manikant, Amrit Lal, Vedika , Aarti, Pranjali Singh Aditya College of Paramedical Science, Satna [email protected]

91 Souvenir Souvenir 92 Abstract: The purpose of the study is about diversity & broad scope of physical therapy, advancement and evidence based practice. Sports-related concussion has gained widespread interest and media attention in recent years due to the potential dangers and complex impairment. Sports Related Concussion (SRC) is defined as “complex pathophysiological process affecting the brain, induced by traumatic biomechanical forces”. Greater emphasis on awareness and education has improved SRC management, but also highlighted the difficulties of diagnosing SRC in a timely manner, particularly immediately after competition. Therefore, challenges exist in off-field assessment and return to play (RTP) protocols, with current traditional approaches largely based on infrequent snapshot assessments. The author conducted a comprehensive search of open access articles of major scientific databases including SPORTDiscus, Cochrane, CINAHL, Google scholar, EMBASE, Academia, PuBMed, SCOPUS, Web of Science, shodhganga, Medline etc. Fiftytwo significant scientific studies were found related to the Preventing undue exertion utilizing Physiogenix cutting edge at technology for Sports Concussions. Thirteen studies were selected based on inclusion criteria. After the research process, out of a total of 52 articles, 13 were included: 05 applied strategic technology & 08 applied only primary traditional approaches. Digital approaches have the potential to transform the way player or participant data can be objectively captured, processed, and analyzed, enhancing current healthcare practice in SRC. Hence, there is significant demand for more sensitive, objective, and scalable solutions for visual assessment in the form of Physiogenix technology & digital twinning. Keywords: Digital twinning, Physiogenix, Sports Related Concussions (SRC). REVIEW ON PREVENTING UNDUE EXERTION UTILIZING PHYSIOGENIX CUTTING EDGE AT TECHNOLOGY FOR SPORTS CONCUSSIONS ICLTIPB/PH/2023/10109 Harshika Gupta Krishan Physiotherapy & Rehabilitation Centre, India [email protected] Abstract: Thymoquinone is a bioactive compound present in the seed powder of the Nigella sativa plant, which belongs to the family Ranunculales. For the analysis of thymoquinone from an ethanolic extract of Nigella sativa seed powder, a sensitive, selective, accurate, and stability-indicating highperformance thin layer chromatographic method (HPTLC) was developed and validated. Mobile phase n-hexane –ethyal acetate – methanol (7:2:1) v/v was used. Chromatography was carried out on aluminium foil-backed silica gel 60 F-254 HPTLC plates. Densitometric analysis was done using a TLC scanner (CAMAG) at 560 nm in reflectance/absorbance mode. In accordance with ICH guidelines, the method was validated for precision, recovery, robustness, specificity, and detection and quantification limits. In the concentration -1 range of 75–500 ng band , the linear regression data for the calibration plots demonstrated a good linear relationship with r2 = 0.998. It was discovered that the system produced compact thymoquinone spots (Rf value = 0.70 ± 0.05). The precision of 1.78% and 1.61%, recovery of 98.8–99.5%, and -1 limits of detection and quantification of 25 and 78 ng band were satisfactory. Thymoquinone is forced to undergo dry heat treatment, oxidation, and photo-degradation. Additionally, the pure thymoquinone was clearly distinguished from the degraded products. Thymoquinone and its degradation products could be successfully separated using the method, making it useful as a stability indicator. This technique provided good resolution from other extract constituents that were present. The technique will be used to analyse and regularly check for the quality of herbal material and formulations containing Nigella sativa. Keywords: Nigella sativa, Thymoquinone, HPTLC, ICH Guidelines, stress degradation. THYMOQUINONE ESTIMATION IN SEED POWDER EXTRACTS OF NIGELLA SATIVA BY HPTLC ANALYTICAL TECHNIQUE ICLTIPB/PH/2023/10110 Nabila Mohamad Taleuzzaman Faculty of Pharmacy, Maulana Azad University, Jodhpur [email protected] Abstract: Clove oil (CO), an essential oil derived from the dried flower buds of the Syzygium aromaticum plant, has been traditionally used for its medicinal properties, including its antifungal (AF) effects. In recent years, several studies have investigated the potential of clove oil as a treatment for topical fungal infections, with promising results. Topical fungal infections are common skin conditions caused by various types of fungi, such as dermatophytes, yeasts, and molds. These infections can be difficult to treat, and conventional antifungal drugs may have side effects or become ineffective due to the emergence of resistant strains. Clove oil contains several active compounds, including eugenol, which has been found to have strong antifungal properties. In vitro studies have shown that clove oil can inhibit the growth of various fungal species, including Candida, Aspergillus, and Trichophyton. In addition, clove oil has been shown to be effective against both drug-sensitive and drug-resistant strains of these fungi. Clinical studies have also demonstrated the potential of clove oil as a treatment for topical fungal infections. In a randomized, double-blind, placebocontrolled study, 60 patients with tinea pedis (athlete's foot) were treated with either a cream containing 5% clove oil or a placebo cream. After two weeks of treatment, the clove oil cream was found to be significantly more effective in reducing the severity of the infection and improving clinical symptoms. Another study investigated the efficacy of a gel containing clove oil and tea tree oil in the treatment of vaginal candidiasis. The gel was applied intravaginally for seven days, and was found to be effective in reducing the symptoms of the infection and improving the vaginal microbiota. Overall, the available evidence suggests that clove oil may be a promising natural alternative for the treatment of topical fungal infections. However, further research is needed to determine optimal dosages and formulations, as well as potential side effects and safety concerns. Keywords: Clove oil, antifungal, placebo, topical, Clinical studies. THE ROLE OF CLOVE OIL IN THE TREATMENT OF TOPICAL FUNGAL INFECTION: A REVIEW ICLTIPB/PH/2023/10111 Priya Chourasia, Anjali, Dr. Kanchan Kohli Lloyd Institute of Management and Technology [email protected] Abstract: Hemp seed oil (HSO) is an increasingly popular natural product with potential therapeutic benefits. It is derived from the seeds of the hemp plant, which is a variety of the Cannabis sativa species that contains low levels of the psychoactive compound THC. In this review, we will discuss the potential therapeutic benefits of hemp seed oil. Anti-inflammatory (AI) properties: Hemp seed oil contains a high concentration of polyunsaturated fatty acids, including omega-3 and omega-6 fatty acids, which have been shown to have AI properties. These fatty acids have been suggested to be beneficial in the treatment of conditions such as arthritis, multiple sclerosis, and inflammatory bowel disease. Skin health: Hemp seed oil has been shown to have moisturizing and anti-inflammatory properties, making it a potential treatment for a variety of skin conditions. Studies have shown that it may be effective in treating conditions such as eczema, psoriasis, and acne. Cardiovascular health: Hemp seed oil has been shown to have potential benefits for cardiovascular health. Its high concentration of alpha-linolenic acid (ALA), an omega-3 fatty acid, has been linked to a lower risk of cardiovascular disease. Additionally, it may help to lower blood pressure and reduce the risk of heart disease. Anxiety and depression: HSO has been suggested to have potential benefits for the treatment of anxiety and depression. It contains compounds that have been shown to have anxiolytic and antidepressant effects, and studies have demonstrated that it may help to reduce symptoms of anxiety and depression. Pain relief: HSO has been suggested to have potential benefits for pain relief. Its AI properties may make it effective in reducing pain associated with conditions such as arthritis and neuropathic pain. Overall, hemp seed oil has shown promising potential for a variety of therapeutic uses. While more research is needed to fully understand its benefits and potential side effects, it is clear that it may have a role to play in a range of health conditions. Keywords: Hemp seed oil, Anti-inflammatory, therapeutic use, potential benefits. THERAPEUTIC POTENTIAL OF HEMP SEED OIL: A REVIEW ICLTIPB/PH/2023/10112 Ashish miglani, Anjali, Kanchan kohli Department of Pharmaceutics, Lloyd Institute of Management and Technology, Greater Noida, Uttar Pradesh, India [email protected]

93 Souvenir Souvenir 94 Abstract: According to WHO, the second leading cause of death worldwide is cancer. The efforts for cancer treatment are early diagnosis and treatment which is challenging because of variability and complexity of tumors. Recent information about cancer has leads to the formulation of novel drug therapy in cancer management like Gene therapy. Gene therapy helps in novel treatment of cancer that plays an important role in preventing death from cancer. The major three different gene therapy approaches are Gene transfer, Oncolytic virotherapy & Immunotherapy. Gene transfer is a flexible technique in which wide ranges of Vectors and Genes are used. In this technique new genes are introduced inside the cancer cell which causes cell death or prevent spreading of cancer by slowing the growth of cancel cell. Viral Particles are used in Oncolytic virotherapy that replicate inside the cancer cell which causes cell death. Modified cells and viral particles are generally used in Immunotherapy which stimulates the immune system to destroy cancer cell. These approaches may be used in Combination or Alone with current approaches to help make cancer a manageable disease. Gene transfer technology allows an incredible diversity of treatment possibilities. This diversity can be used to complement traditional therapies as well as provide radically new frontiers for treatment. The field of Novel cancer gene therapy is rapidly developing and will be the part of the Cancer therapy in the future. Gene transfer technology helps in increasing the effectiveness of the current cancer treatment like Chemotherapy. Many trials are in progress which ensures the significant advantages of gene therapy for cancer treatment. There is a great hope that these advances will help relegate cancer to a manageable chronic disease without several suffering and deaths. Keywords: Gene transfer, Immunotherapy, Oncolytic virotherapy, Cancer, Death. RECENT APPROACHES FOR CANCER TREATMENT THROUGH GENE THERAPY ICLTIPB/PH/2023/10113 Dhruva Garg, Dr. Manish Kumar M.M. College of Pharmacy, M.M.(DU) Mullana, Ambala, Haryana, India [email protected] Abstract: Colorectal Cancer is major cause of mortality and morbidity worldwide. The migration and invasion features, which are associated with epigenetic, oxidative and inflammatory alteration response, act as vitalroles in the development of colon cancer.Themolecularsignallingpathwaysinhumancoloncancer cells remain unclear.Hence,the present study was conducted to investigate the effect of BGT222 on migratory and invasive activity of colon cancer and the involvement of epigenetics cascades (dnmt-1, 5-mc, Hdac) and Signalling (Raptor, Mtor, caspas-9) other underlying mechanism. An optimal antitumor drugwouldbeonewhichselectivelyinducesapoptosisandinhibit thecellprogressioncancerous cellsbutnotinnormal cells.Using Caco-2 cells we focused on the family of proteins, (dnmt-1, 5-mc, Hdac) and Signalling (Raptor, Mtor, caspas-9) mitochondrial pathways in caco-2 cell lines. Techniques employed included western blots, immunofluorescence, Cell migration assay, DLS, Zeta potential, FTIR, TEM as well as experiments with drug inhibitors of specific pathways. Nanoparticles inhibited the cell migration, invasion; Proliferation of caco-2 cell lines as demonstratedbydownregulationofMtoraccompaniedbyRaptor inhibition, induced apoptotic levels. Also we have explored the down regulation of epigenetics pathways, (Dnmt-1, Hdac) which represents the anticancer property of our selected drug candidate. In the present study, we analysed the signalling cascades in Caco-2 cells undergoing apoptosis after stimulation with BGT222. The signalling cascade emerged from the mitochondria resulting in initial activation of caspase-9 and subsequently stimulation of downstream Mtor, Raptor, DNMT-1, HDAC. Specific inhibition of this particular caspase with flavonoids inhibitors alter the signalling, epigenetic, apoptotic cascades of Caco-2 cells to BGT222. BGT222 inhibition mechanism of mTORC differs markedly from that ofrapamycin in Caco-2 cells. BGT222 repressed mTORC1 signalling by a twopronged mechanism involving the repression of Raptor/mTOR signalling cascade and down-regulated the epigenetic biomarkers DNMT-1, HDAC. In contrast, rapamycin (at 200-400 nM)inhibitedmTORC,RaptorsignallinginCaco-2celllines. Keywords: Colorectal Cancer, BGT222, Raptor, HDAC, rapamycin. BGT222 LOADED SOLID LIPID NANOFORMULATION SUPPRESSES THE MIGRATION AND INVASION IN HUMAN COLON CANCER CACO-2 CELLS VIA MODIFICATION OF RAPTOR, HDAC, DNMT-1, OXIDATIVE AND APOPTOTIC CASCADES ICLTIPB/PH/2023/10114 Satyam Sharma, Sanjiv Singh Department of Pharmacology & Toxicology, National Institute of pharmaceutical education and research, Hajipur, Bihar [email protected] Abstract: The dengue is most common viral disease spread by mosquitoes with the quickest spreading disease in the world. The worldwide population of 3 billion people approximately 50% are at risk. Over 125 countries, 50 to 270 million people suffer fromdengue infection every year in which 21000 people face death due to synthetic medications. Moreover, It has various side effects too. That's why we have approached Herbal formulations which have minimal side effects. The present research project is to formulate polyherbal syrup by using the extract of Carica papaya for increasing platelet count, extract of Trigonella foenumgracium for hepatic protection of cells of liver and extract of Azadirachata indica antiviral and antipyretic effect. The syrup was prepared according to I.P by mixing all the excipients and the herbal extracts. We have developed six batches of herbal syrup namely F1H, F2H, F3H, F4H, F5H and F6H. All batches were evaluated for different parameters like appearance, PH, viscosity, taste, density, specific gravity. All the formulations showed good appearance, PH, adequate viscosity and other parameters out of which F3 and F4 were the best of all. All the formulations were stable at room temperature. Further studies are still going on with F3 and F4 formulations. Keywords: Dengue, Epidemiology, Etiology, Importance of herbs, Mechanism of action. FORMULATION AND EVALUATION OF POLY HERBAL SYRUP FOR TREATMENT OF DENGUE ICLTIPB/PH/2023/10115 Raunak Mishra, Aditi Sinha, Shivangi Kesharwani Aditya College of Pharmacy, Satna [email protected] Abstract: Hyperpigmentation of the lips is a common condition. It is associated with a wide variety of conditions that include physiologic changes, genodermatoses, inflammatory diseases, endocrinologic disorders, drugs and chemicals, benign and malignant neoplasm, and other non-melanotic conditions. The lip care products of day-to-day use contain heavy metals and preservatives in their formulations. The heavy metals have adverse effects on the lips and affect the nervous and cardiac functioning and Carcinoma of various vital organs. The aim of this article is to formulate and characterize herbal extract containing lip balm for the treatment of lip pigmentation. The five formulation of herbal lip balm can be made by using natural base, extract of beet root, carrot and rose, natural oils, color and flavoring agents which can be evaluated for their resistance to temperature variations, pleasant flavor, stability, spreadability, smoothness during application, adherence & easily removal, and decrease pigmentation. Among all the formulation F4 was gives best result. Keywords: Lip Pigmentation, Endocrinologic, Genodermatoses, Herbal Extract, Neoplasm. FORMULATION AND CHARACTERIZATION OF HERBAL EXTRACT CONTAINING LIP BALM FOR THE TREATMENT OF LIP PIGMENTATION. ICLTIPB/PH/2023/10116 Akanksha Mishra, Shivangi Kesharwani Aditya College of Pharmacy, Satna [email protected]

95 Souvenir Souvenir 96 Abstract: The pharmaceutical industry is attempting to discover thin films as a new drug delivery system. Thin films have been described as an alternative approach to conventional dosage forms. They are versatile platforms that provide fast, local, or systemic effects. Additionally, these systems can be easily applied by themselves, especially for dysphagia patients, geriatric, pediatric, or bedridden patients, as well as patients who cannot easily access water. The aim of the present study was to formulate a taste masked rapid dissolving film of frovatriptan succinate, which can overcome the problem faced by conventional dosage form, increase the low bioavailability and improve patient compliance. The formulations were prepared by solvent casting method, using film forming polymer, propylene glycol as plasticizer, croscarmellose sodium as disintegrant, aspartame as sweetener, citric acid as saliva stimulant, wild cherry as flavor and Brilliant blue dye for elegance was selected for RDF preparation. In the present study final formula was optimized by simplex lattice mixture design using statease design expert software to give the optimized batch. The optimized batch (OB) prepared with concentrations of Polymer, Plasticizer and Disintegrant at 43.33, 8.33 and 3.33 respectively by solvent casting method. OB showed In-vitro disintegration time of 42sec, Tensile strength of 7.36 MPa and Percentage elongation of 4.66%. From the present study it may be concluded that the Rapid dissolving films of Frovatriptan succinate can be prepared by solvent casting method using HPMC E3 and E15 in 85:15 ratio respectively and final formula was optimized by simplex lattice mixture design using statease design expert software to give the optimized batch. Keywords: migraine, triptan, drug delivery, absorption, rapid dissolving film. RAPID DISSOLVING FILM FOR NOVEL DRUG DELIVERY SYSTEMS: A NEW ROUTE FOR QUICK MIGRAINE RELIEF ICLTIPB/PH/2023/10117 Ajeet Kumar Bhagwant University, Ajmer, Rajasthan, India. [email protected] Abstract: The Objective of present research work is to formulate and evaluate the film coated atorvastatin oral tablet using finger millet starch as a natural disintegrant, and compared with the marketed product (Lipitor). In present research work the film coated tablets of Atorvastatin were prepared using finger millet (eleusine corocana) starch a natural disintegrant by wet granulation method. At initial stage preformulation studies were carried out to check physicochemical properties of the drug and compatibility with excipients. Eight formulations were prepared and evaluated for minimum possible disintegrating time to optimize the best formulation, and all parameters were compared with marketed product (Lipitor). All were evaluated at pre and post compression phases also. All the batches, then further evaluated for hardness, thickness, weight variation, drug content uniformity, In vitro disintegration time and In vitro release studies. All the prepared formulations show significant result obtained by Pharmacopoeial quality control test. On the basis of disintegration test observations formulation were found. Results show that, there is no significant difference in the disintegration time or dissolution rate of tablets containing the two different starches. Tablets containing finger millet (eleusine corocana) starch met compendia requirements for disintegration time and dissolution rate. The starch is recommended as a disintegrant in tablet formulation. Keywords: Oral Tablet; Disintegrant; Dissolution testing; Starch; Film coated; Finger millet. FORMULATION DEVELOPMENT AND EVAULATION OF ATORVASTATIN TABLET BY USING FINGER MILLET (ELEUSINE COROCANA) STARCH AS NATURAL DISINTEGRANT ICLTIPB/PH/2023/10118 Hanumant Ji Sharma, Ajeet Kumar * Department Of Pharmacy, Vivek College Of Technical Education Bijnor,U.P.-246701. [email protected] Abstract: The genera Dracaena and Sansevieria (Asparagaceae) are still poorly resolved phylogenetically. Plants of these genera are commonly distributed in Africa, China, Southeast Asia, and America. Most of them are cultivated for ornamental and medicinal purposes and are used in various traditional medicines due to the wide range of ethnopharmacological properties. Extensive in vivo and in vitro tests have been carried out to prove the ethnopharmacological claims and other bioactivities. These investigations have been accompanied by the isolation and identification of hundreds of phytochemical constituents. The most characteristic metabolites are steroids, flavonoids, stilbenes, and saponins; many of them exhibit potent analgesic, antiinflammatory, antimicrobial, antioxidant, cytotoxic activities. Polarised light microscopy and scanning electron microscopy of these fibres revealed a hierarchical cell structure that consisted of a primary wall, a secondary wall, a fibre lumen and middle lamellae. The cross-sectional area and porosity fraction of the fibre were estimated to be approximately 0.0245 mm2 and 37%, respectively. The fibre density and fineness were approximately 0.915 ± 0.005 g/cm3 and 9 Tex, respectively. An X-ray diffraction and Fourier transform infrared analysis of the fibres showed the presence of cellulose with a crystallinity index of 60%. The microstructural, physical, chemical and mechanical properties of Sansevieria cylindrica fibres are described for the first time in this work. A microstructural analysis of S. cylindrica leaves showed the presence of structural fibers and arch fib tensile tests showed that the corrected Young's modulus was approximately 7 GPa, the tensile strength was 658 MPa, and the total elongation was between 10% and 12%. Keywords: Dracaena, phytochemical, Raptor, Fourier transform, Young's modulus. PHARMACOLOGICAL SCREENING OF SANSEVERIA CYLINDRICA IN MANAGEMENT OF OBESITY ICLTIPB/PH/2023/10119 Abhishek Marwari, Akash Jain MM college of Pharmacy Research Scholar MMDU Mullana Ambala. [email protected] Abstract: The aim of the present work is to evaluate extract of Carica papaya leaves.Carica papaya (Family: Caricaceae). Carica papaya leaf extract is utilized as a medicinal treatment for liver disorders, especially for those kinds that are parasitic. Alkaloids pseudocarpain, dehydrocarpaine I and II, choline, carposide, vitamin C, vitamin A, and vitamin E are found in 99 Leaves. The Chief vessel has papain in it (C6H14N4O3, MW226.23). The young leaves are used medically in jaundice, urinary traits, gonorrhea, digestive conditions, bacterial infections, vermifuge, dengue fever, beriberi, abortion, asthmatic, malaria and issues with the skin. The green, yellow, and brown Carica papaya leaf included a variety of nutrients and supplements. The analysis showed that saponins, cardiac glycoside, alkaloids, vitamins, and mineral components are all present in the leaves. Antioxidant activity of the extracts was evaluated by using Diphenyl picryl hydrazyl (DPPH) radical scavenging. Hepatoprotective activity of the extracts was investigated by D-galactosamine induced liver damage model in rats. Hepatoprotective activity of the extracts was investigated by D-galactosamine induced liver damage model in rats.D-galactosamine s i g n ifi c a n tl y i n c r e a s e d t h e l e v e l s o f a l a n i n e aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bilirubin and tissue TBARS levels. Pre-treatment of the rats with extract of Carica papaya leavesinhibited the increase in serum levels of ALT, AST, ALP, total bilirubin and tissue TBARS levels. The inhibition was comparable with silymarin (25mg/kg p.o). Dgalactosamine induced significant decrease in tissue glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), serum protein level, and serum albumin. Pretreatment of the rats with aqueous extract of Carica papayleaves showed significant increase in tissue GSH, SOD, CAT, serum protein, and serum albumin level. The present study revealed that Carica papaya leaves have significant antioxidant and hepatoprotective activity. Keywords: Carica papaya, DPPH, D-galactosamine, TBARS levels. PHARMACOLOGICAL EFFECTS OF EXTRACT OF CARICA PAPAYA LEAVES ICLTIPB/PH/2023/10120 Chhavi Verma, Rizwan Ahmad Vivek College of Technical Education (Bijnor) [email protected]

97 Souvenir Souvenir 98 Abstract: Acne vulgaris is a chronic inflammatory skin disorder that affects approximately 80% adolescent during puberty stage. Propionibacterium acne is a bacterium that causes the condition known as acne, which is characterised by excessive oil production in the sebaceous glands and is typically treated with antibiotics. The use of herbal medicine has multiplied in response to the growing threat posed by antibiotic resistance. In the current investigation, two medicinal plants were chosen to create a polyherbal gel to treat acne vulgaris issues: Acorus calamus and Ocimum tenuiflorum. For the creation of topical gel, fresh leaf extracts and the polymer Carbopol 940 were used in various concentrations. The produced gel was examined for a number of physical characteristics, including pH, colour, odour, grittiness, viscosity, homogeneity, spreadability, skin irritancy, etc. after being maintained at room temperature for 24 hours. The gels were subjected to microbial study against Propionibacterium acne. The developed gel and the commercially available standard medication were also contrasted. Based on the above mentioned investigation, it was discovered that the Polyherbal gel formulation performed well across all evaluation criteria. Formulated gel also shows significant antibacterial activity against Propionibacterium acne with no irritation. After comparison with the standard drug (Aquaday capsule), it became clear that the produced gels' zone of inhibition was larger than that of the standard drug. The conclusion of the study was that the polyherbal gel with extracts of Acorus calamus and Ocimum tenuiflorum, each at a concentration of 7.5 mg, was a suitable formulation for the treatment of acne vulgaris and may thus be preferable to allopathic therapy. Keywords: Propionibacterium acne, Acorus calamus, Acne vulgaris, Contact Allergy. FORMULATION DEVELOPMENT & EVALUATION OF DERMATOLOGICAL POLYHERBAL GEL FOR ACNE TREATMENT ICLTIPB/PH/2023/10121 Abhay Pratap Singh, Ajeet Kumar Vivek College Of Technical Education, Bijnor [email protected] Abstract: Garlic preparations and propranolol (PRO) are agents recognized as cardioprotective and potent antihypertensive agents when they are used individually. However, there is no report available to explain the role of combined therapy during simultaneous hypertension and myocardial damage in rats. The influence of garlic on pharmacokinetics of propranolol was determined by HPLC method; while pharmacodynamic interaction was studied in animals with hypertension (10% fructose) and myocardial damage (isoproterenol, 175mg kg−1, s.c. 2 days). Propranolol was −1 given orally at 10mg kg for 1 week, whereas, garlic homogenate was administered at two different doses of Albino rats were treated orally with garlic homogenate (250 and 500 mg/kg) for fourth to sixth week of high fructose period, once daily. Biochemical, electrocardiographic, haemodynamic and histopathological parameters were studied. Administration of GH resulted in decrease in lactate dehydrogenase and creatine phosphokinase-MB activities in serum and increase in heart tissue homogenate compared to propranolol control. The SOD and Catalase activities were found to be increased in all treated groups compared to propranolol control. The QRS duration, QT segment and RR intervals were normalized by GH and propranolol treatments. Histological scores confirm the biochemical and electrocardiographic findings. The combined therapy of GH 250mg kg−1 and propranolol was found to be most effective in reducing SBP, cholesterol, triglycerides and glucose. These observations suggest that careful addition of garlic in moderate doses in PRO regimen might result in beneficial effect during treatment of hypertensive animals with myocardial damage. Keywords: Garlic, HPLC, Albino rats, hypertensive animals, myocardial damage. INTERACTION OF ANTIHYPERTENSIVE DRUG WITH GARLIC IN RAT ICLTIPB/PH/2023/10122 Anamika Gautam Division of Pharmaceutical Science, Teerthankar Mahaveer University, Moradabad, India [email protected] Abstract: The advancement of novel drug delivery system have more consider in now days. Nanoparticles have the special qualities of various fields like magnetic, optical, electrical and pharmaceuticals. The nanoparticles are diameter in the range of 1-100 nm. In this review, different methods of synthesis of nanoparticles are discussed to obtain desired nanoparticles with specific sizes and shapes. The study of different methods of synthesis of nanoparticles is essential to obtain desired nanoparticles with specific sizes and shapes. There are two main approaches such as top-down and bottom-up are used for the synthesis of nanoparticles as well as physical, chemical and biological method also. By these methods, Nano-particles are prepared for desired sizes and different forms. The Nano-formulations have the properties of controlled release and high stabilized dosages forms. For the Nano formulation, hydrophilic and hydrophobic both drugs are used this delivery system. There are various merits of nanomaterial such as enhance the solubility and bioavailability and also increased the therapeutic activity as well as the penetrability of drugs. In the various method of the preparation of nanoparticle, bottom-up methods are abduanced for the preparation of Nano forms. This is very unique method for the synthesis of Nano forms for the development of novel formulation. In this review, we illustratedmany method of synthesis of nanoparticles applied in the drug delivery system. Keywords: Nanoparticles, top-down method, chemical, biological method, applications. A REVIEW ON THE METHODS OF PREPARATION OF NANOPARTICLES AND APPLICATIONS ICLTIPB/PH/2023/10123 Neha Singh Department of Pharmaceutics, Teerthanker Mahaveer University, Moradabad [email protected] Abstract: Various plants are being used in complementary and alternative medicines for Nootropic activity. Attention is being focused on the investigation of the efficacy of plantbased drugs used in the traditional medicinal system because they are cheap, have little side effects and according to WHO, about 80% of the world population still rely mainly on herbal remedies.The present work was under taken to evaluate the Nootropic activity of Chenopodium album leaves extracts in Scopolamine induce Alzhimer type Dementia in rats. For the purpose ethanolic & aqueous extract of Chenopodium album leaves were prepared and screened for phytochemical constituents and Nootropic activity. For pharmacological activity Wistar rats weighing 150-200 g were randomly divided in to seven groups (n=6/group). Group I served as normal control & received vehicle; Group II served as Scopolamine control & received vehicle; Group III standard drug piracetam (150 mg/kg, i. p); Groups IV & V were administered with ethanolic extract of Chenopodium album leaves (250 & 500 mg/kg respectively, p.o) and Groups VI & VII received aqueous extract of Chenopodium album leaves (250 & 500 mg/kg respectively, p.o). All treatments were given orally & intraperitonial started after 14 days inject Scopolamine (except normal control group) and continued for 14 days along with Scopolamine. The phytochemical screening of ethanolic & aqueous extracts showed the presence of alkaloids, saponins, quinones, coumerins, sugar and gums. Ethanolic and aqueous extract of Tectona grandis leaves at 250 and 500 mg/kg showed decrease in MDA, LDH, Nitrite and restored SDH and GSH level. From the present study it can be concluded that aqueous and ethanolic extracts of Chenopodium album leaves extracts possess significant Nootropic activity against Scopolamine induce Alzhimer type dementia in rats. It appeared from the study that, the activity of ethanolic and aqueous extract of Chenopodium album leaves could be due to presence of flavonoids, tannins, diosgenin, quinones and saponins. However, detailed phyto-pharmacological study of leaves extracts will be useful to pin point the activity. Keywords:Chenopodium album, SDH, GSH, tannins. EVALUATION OF CHENOPODIUM ALBUM LEAVES EXTRACTS FOR NOOTROPIC ACTIVITY POTENTIAL IN WISTAR RATS ICLTIPB/PH/2023/10124 Lalit Kumar, Jitendra Singh Krishna Pharmacy College, Bijnor | [email protected]