99 Souvenir Souvenir 100 Abstract: Various plants are being used in complementary and alternative medicines for Nootropic activity. Attention is being focused on the investigation of the efficacy of plant-based drugs used in the traditional medicinal system because they are cheap, have little side effects and according to WHO, about 80% of the world population still rely mainly on herbal remedies. The present work was under taken to evaluate the Nootropic activity of Dracaena trifasciata leaves extracts in Scopolamine induce Alzhimer type Dementia in rats. For the purpose ethanolic & aqueous extract of Dracaena trifasciata leaves were prepared and screened for phytochemical constituents and Nootropic activity. For pharmacological activity Wistar rats weighing 150- 200 g were randomly divided in to seven groups (n=6/group). Group I served as normal control & received vehicle; Group II served as Scopolamine control & received vehicle; Group III standard drug piracetam (200 mg/kg, i. p); Groups IV & V were administered with ethanolic extract of Dracaena trifasciata leaves (250 & 500 mg/kg respectively, p.o) and Groups VI & VII received aqueous extract of Dracaena trifasciata leaves (250 & 500 mg/kg respectively, p.o). All treatments were given orally & intraperitonial started after 17 days inject Scopolamine (except normal control group) and continued for 18 days along with Scopolamine. The phytochemical screening of ethanolic & aqueous extracts showed the presence of alkaloids, saponins, quinones, coumerins, sugar and gums. Ethanolic and aqueous extract of Tectona grandis leaves at 250 and 500 mg/kg showed decrease in MDA, LDH, Nitrite and restored SDH and GSH level. From the present study it can be concluded that aqueous and ethanolic extracts of Dracaena trifasciata leaves extracts possess significant Nootropic activity against Scopolamine induce Alzhimer type dementia in rats. It appeared from the study that, the activity of ethanolic and aqueous extract of Dracaena trifasciata leaves could be due to presence of flavonoids, tannins, diosgenin, quinones and saponins. However, detailed phyto-pharmacological study of leaves extracts will be useful to pin point the activity. Keywords: Nootropic Activity, WHO, Scopolamine, Tectona grandis. MEMORY ENHANCING ACTIVITY OF DRACAENA TRIFASCIATA LEAVES EXTRACTS ON SCOPOLAMINE INDUCED AMNESIA IN WISTAR RATS ICLTIPB/PH/2023/10125 Sarita Rani, Ankur Garg Vivek College of Technical Education, Bijnor | [email protected] Abstract: Hypertension, or high blood pressure, is a very common and serious condition that can lead to or complicate many health problems. The risk of cardiovascular morbidity and mortality is directly correlated with blood pressure. Risks of stroke, MI, angina, heart failure, kidney failure or early death from a cardiovascular cause are directly correlated with BP. The World Health Organization has estimated that high blood pressure causes one in every eight deaths, making hypertension the third leading killer in the world. Globally, there are one billion hypertensives and four million people die annually as a direct result of hypertension. In the Eastern Alternative medicine offers an effective way to decrease the rising number of people with high blood pressure. Research has found a variety of alternative therapies to be successful in reducing high blood pressure including diet, exercise, stress, management, supplements and herbs. Every year, more and more studies are being performed on herbal remedies for high blood pressure. Various plants are being used in complementary and alternative medicines for management of Hypertension. Attention is being focused on the investigation of the efficacy of plant-based drugs used in the traditional medicinal system because they are cheap, have little side effects and according to WHO, about 80% of the world population still rely mainly on herbal remedies. Rumex nepalensis leaves is used in traditional medicine to treat many diseases including hypertension. This study aimed to evaluate the curative effects of the hydro-alcoholic extract of Rumex nepalensis on hypertension. Rumex nepalensis is commonly known as Nagarmotha and it belongs to the family Cyperacea. Treatment of hypertensive rats with Rumex nepalensis or nifedipine significantly improved lipid profile, hepatic and renal functions, and antioxidant status. The curative effect of Rumex nepalensis extract on hypertension is probably related to its antihypertensive, hypolipidemic, and antioxidant activities, which justifies its empirical use in the treatment of hypertension. Keywords:Hypertension, WHO, herbal medicines, antioxidant. EVALUATION OF THE ANTIHYPERTENSIVE EFFECT OF RUMEX NEPALENSIS LEAVES EXTRACTS ON ETHANOL-INDUCED HYPERTENSION IN WISAR RATS ICLTIPB/PH/2023/10126 Ajay Kumar, Ankur Garg Vivek College of Technical Education, Bijnor | [email protected] Abstract: Liver is a vital organ that plays a major role in the elimination of xenobiotics from the body. Diseases that affect the liver become major health problems and challenge health-care professionals as well as the pharmaceutical industry. Since the conventional treatment of liver diseases is associated with a wide range of adverse effects, botanical agents are commonly used. Among these agents, Clutia abyssinica is the most widely used herb in Ethiopian traditional medicine. To evaluate the hepatoprotective activity of the crude 80% methanol extract and solvent fractions of Commelina benghalensis leaves in rats. The leaves of Commelina benghalensis were extracted by cold maceration using 80% methanol as a solvent, and the solvent fractions were obtained in liquid–liquid extraction with chloroform, n-butanol and distilled water. Male mice were treated with the vehicles (distilled water or 2% Tween 80), three different doses (100, 200 and 400 mg/kg) of the crude 80% methanol extract and three solvent fractions, the standard drug (silymarin 100 mg/kg), and the hepatotoxicant carbon tetrachloride (CCl4). Then, the levels of biomarkers of liver injury – such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) – and liver function such as total protein, albumin, and bilirubin were measured. Evaluation of the change in body weight and liver weight, histopathologic examination and in vitro antioxidant assay against ethanol-induced hepatotoxicity were also carried out. The 80% methanol extract decreased the absolute and relative weight of the liver of rats at the doses of 200 and 400 mg/kg (p< 0.01 and p< 0.001, respectively). It also suppressed the plasma levels of AST, ALT and ALP (p< 0.001) in the aforementioned doses. Among fractions, the n-butanol fraction showed maximum hepatoprotective activity in its dose of 200 and 400 mg/kg (p< 0.001, in all cases). Likewise, the chloroform fraction (400 mg/kg) reduced to a similar extent (p< 0.001 in all cases). In stark contrast, the aqueous fraction failed to affect the levels of all biomarkers of hepatocyte injury. The crude methanol extract and n-butanol fraction were able to return the normal hepatic architecture of hepatocytes and scavenge free radicals in the1,1-diphenylpicrylhydrazyl (DPPH) assay. Commelina benghalensis is endowed with hepatoprotective activity, probably mediated via its antioxidant activity. Thus, Clutia abyssinica can be taken as one candidate for the development of hepatoprotective agents because of its good safety profile. Keywords:Liver, traditional medicine, AST, Clutia abyssinica. HEPATOPROTECTIVE ACTIVITY OF THE COMMELINA BENGHALENSIS LEAVES IN ETHANOL-INDUCED HEPATOTOXICITY IN RATS ICLTIPB/PH/2023/10127 Anushka, Ankur Garg Vivek College of Technical Education, Bijnor | [email protected] Abstract: Rubus ellipticus has been used to treat peptic ulcer disease in Ethiopian folk medicine, but its efficacy has not been validated. The present study was therefore carried out to evaluate the anti-ulcer activity of 80% methanol leaf extract of RE in rats. The effect of RE extract on gastric ulcer in rats in pylorus ligation-induced and ethanol-induced models was studied using single dosing (100, 200, 400 mg/kg) and repeated dosing (200 mg/kg for 10 and 20 days) approaches. Ranitidine (50 mg/kg) and sucralfate (100 mg/kg) were used as the standard drugs. Depending on the model, outcome measures were volume and pH of gastric fluid, total acidity, ulcer score, percent inhibition of ulcer score, ulcer index as well as percent inhibition of ulcer index. Data were analyzed using one-way analysis of variance followed by Tukey's post hoc test, and P<0.05 was considered as statistically significant. RE significantly (P<0.001) reduced gastric ulcer index by 55.82% and 62.11%, respectively, in pylorus ligation-induced and ethanol-induced ulcer models at the 400 mg/kg dose, which is comparable to the standard drugs. Ten and 20 days pre-treatment with RE200 exhibited significant (P<0.001) ulcer inhibition by 66.48% and 68.36% (pylorus ligation-induced model) as well as 71.48% and 85.35% (ethanolinduced model), respectively. RE possesses both dosedependent and time-dependent anti-ulcer effect in the two models. The oral median lethal dose (LD50) is estimated to be higher than 2000 mg/kg for the crude hydroalcoholic extract, and secondary metabolites such as flavonoids, tannins, and saponins were present. The findings of this study confirmed that RE has anti-ulcer pharmacologic activity due to one or more of the secondary metabolites present in it. Therefore, this study validates its anti-ulcer use in Ethiopian folk medicine. Further investigations on isolation of specific phytochemicals and elucidating mechanisms of action are needed. Keywords:Rubus ellipticus, RE, Ranitidine, LD50. EVALUATION OF ANTIULCER ACTIVITY OF LEAVES OF RUBUS ELLIPTICUS IN EXPERIMENTAL ANIMAL ICLTIPB/PH/2023/10128 Anjali, Ankur Garg Vivek College of Technical Education, Bijnor | [email protected]
101 Souvenir Souvenir 102 Abstract: The Cadamba is one of the important medicinal plants belonging to the Rubiaceae family. It is crucially significant as it has the largest number of phytochemicals and secondary metabolites (viz., cadambagenic acid, cadamine, quinovic acid, β-sitosterol, cadambine, etc.) having pharmacological and biological properties. It can be used as an alternative to various synthetic chemical compounds in the prevention as well as the treatment of several incurable diseases. Dried and meshed leaves of cadamba was taken for the aqueous and ethanolic extract which was carried out by Soxhlet extraction process. Various analytical parameters (Foreign matters, total ash, Alcohol soluble extractive value and Water soluble extractive value)of Cadamba extract was carried out. Azithromycin and piperazine citrate were used as standard and control respectively. The anthelmintic activity of aqueous and ethanolic extracts of anthocephalus cadamba leaves was carried out against an adult Indian earthworms, Pheritima posthuma.Each group was given aqueous and ethanolic extracts in doses ranging from 10 mg/ml to 25 mg/ml, as well as a vehicle (piperazine citrate, 20 mg/ml, produced in 1% tween-80).Significant, as a result the antimicrobial activity was observed for both ethanolic and aqueous extracts at the concentration of 15 mg/ml against the tested organisms. Hence the extract of cadamba leaves shows their action over helmintics bacteria. Keywords: Anthocephalus cadamba, Soxhlet extraction, Azithromycin, Pheritima posthuma. DETERMINATION AND EVALUATION OF ANTHELMINTIC ACTIVITY OF THE LEAF EXTRACT OF ANTHOCEPHALUS CADAMBA MIQ ICLTIPB/PH/2023/10130 Ashish Kumar Krishna Pharmacy College, Bijnor | [email protected] Abstract: On a world scale, obesity has reached epidemic proportion and is a major contributor to the world burden of chronic disease and disability. According to WHO, obesity is related to cardiovascular disease, hypertension, endocrine disorders, diabetes mellitus, gallbladder disease, cancer, metabolic disturbances, osteoarthritis, gout & pulmonary disease, as well as psychological issues, including social bias, prejudice, discrimination, and overeating.. Many antiobesity drugs are available in the market. However, they exhibit side effects, such as gastrointestinal and kidney problem, only orlistat and sibutramine can be used longterm, in spite of issues regarding weight loss and tolerance. These considerations implicate the search for new antiobesity agents that have a fast onset of action, with less side effects and a wider safety margin. For pharmacological activity Wistar rats weighing 150-200 g were randomly divided in to seven groups (n=6/group). Group I served as normal control Group II served as CD control & Group III received standard drug Orlistat (30 mg/kg); Groups IV & V were administered with aqueous extract of Chenopodium album leaves (250 & 500 mg/kg respectively) and Groups VI & VII received ethanolic extract of Chenopodium album leaves (250 & 500 mg/kg respectively). All treatments were given orally, started after 6 weeks feeding with CD (except normal control group) and continued for six weeks along with CD. Weight gain, feed intake, BMI, obesity index, lipid profile, blood glucose and body fat depots content were the parameters evaluated. The phytochemical screening of ethanolic & aqueous extracts showed the presence of alkaloids, saponins, quinones, coumerins, sugar and gums. Ethanolic and aqueous extract of Chenopodium album leaves at 250 and 500 mg/kg showed reduction in weight gain, feed intake, BMI, obesity index and significant decrease in serum glucose, triglyceride, total cholesterol with increase in HDL level, Also, these was significant decrease body fat depots when compared to CD control group. From the present study it can be concluded that aqueous and ethanolic extracts of Chenopodium album leaves extracts possess significant antiobesity activity against Cafeteria diet induced obesity in rats. It appeared from the study that, the activity of ethanolic and aqueous extract of Chenopodium album leaves could be due to presence of flavonoids, tannins, diosgenin and saponins. However, detailed phyto-pharmacological study of leaves extracts will be useful to pin point the activity. Keywords:WHO , RE, BMI, LD50. PRECLINICAL SCREENING OF CHENOPODIUM ALBUM LEAVES EXTRACTS FOR ANTI-OBESITY ACTIVITY ICLTIPB/PH/2023/10129 Ayushi Bhatnagar, Ankur Garg Vivek College of Technical Education, Bijnor | [email protected] Abstract: The objective of the study was to develop the oral dispersible concentrations of polymers on in-vitro release rate from the prepared Rosuvastatin calcium tablets. The effect of drug to polymer ratio on the in vitro drug release behavior was significant. Formulation F4 showed better in vitro drug release and this indicates the ideal drug, polymer and excipients combination formulations. An Oral Dosage Form is the physical form of a dose of a chemical compound used as a drug or a medication intended for administration or consumption by oral route. The tablets were prepared by wet granulation method by optimizing different concentrations of Sodium Starch Glycolate as disintegrating agent and PVPK30 as binder. The granules possessed good flow properties and were compressed into tablets. The formulated tablets were evaluated for uniformity of weight, hardness, thickness, diameter and friability. The formulated tablets possessed diameter of 1.4±0.03cm, thickness of 0.34±0.04)cm, hardness 0.8±0.06kg/cm2, friability 0.6±0.02% and showedweight variation within the range 201±1.12%. All the batches fulfilled the pharmacopeial requirements of tablets. The optimized batch F4 exhibited better drug release profile than marketed tablet. In vitro dissolution results showed that maximum cumulative % drug release was more in formulation F4 when compared to formulation F1 to F6.Stability studies were conducted formulations F4 stored at 25°c/60% RH and 40°c/75% RH for 30 days. Various parameters like hardness, friability, drug content uniformity, in vitro disintegration, wetting time were analyzed at a time of interval of 10 days till a period of 30 days. Not much variation or change was observed in any parameters throughout the study period. Best –selected formulations F4 found to be stable. Hence it is concluded that The prepared tablets disintegrate in seconds without need of water and enhance the absorption, this leads to increased bioavailability of Atorvastatin calcium. The results of stability study on Formulation F4 after a period of one month indicates that the formulation was stable. Based on result it is concluded that formulated oral dispersibletablet of Rosuvastatin may have wide acceptance as compared to conventional dosage form. Keywords: oats, nutraceutical potential,Rosuvastatin calcium, cholesterol, wet granulation FORMULATION DEVELOPMENT AND EVALUATION OF TABLET CONTAINING ROSUVASTATIN WITH NEUTRACEUTICAL POTENTIAL ICLTIPB/PH/2023/10131 Dipanshu Kumar, Ajeet Kumar Vivek College of Technical Education, Bijnor | [email protected] Abstract: The purposes of the current study were the design and evaluate the inclusion complex of gliclazide using hydroxyl propyl beta cyclodextrin in order to increase the bioavaliabilty of the drug. The objective of the study is to develop inclusion complex. The developed formulation will be characterised for in vitro studies. The gliclazide inclusion complex with hydroxy propyl-β-cyclodextrin was prepared by co-precipitation method techniques. The different ratio of drug and polymer were used to develop the formulations. The inclusion efficiency of different formulations was determined quantitatively by UV spectrophotometry. The invitro dissolution profiles of all formulation were determined. The formulation which shows maximum release of drug was taken for its characterization. The analytical method was developed and validated with respect to the ICH guidelines (ICH, 1995) and parameters such as Linerity, Range, Accuracy, Precision. The all the characterization parameters predicted the optimized formulation by use of various analytical methods The in- vitro release studies showed the better release of the drug from formulation in comparison to pure drug. The drug release measured as percentage of drug release of 55.67 % in 30 min. and after 3 hrs, % cumulative drug release was measured as 94%. The percentage cumulative drug release is higher than drug suspension. The formulation shows the better release pattern. Thus, it can be concluded that inclusion complex formulation prepared by complexatation manufacturing strategy had better dissolution profile as compared to the conventional formulation which finally enhanced anti-diabetic activity. The HP-ß-CD used in formulation of inclusion complex helped in solubility of drug in dissolution media and hence increases bioavailability. Keywords:Cyclodextrin, gliclazide, UV, ICH. DEVELOPMENT AND EVALUATION OF THE INCLUSION COMPLEX OF GLICLAZIDE WITH HYDROXY-PROPYLBETA- CYCLODEXTRIN ICLTIPB/PH/2023/10132 Mukul Kumar Rana, Ajeet Kumar, Ankur Garg Vivek College of Technical Education, Bijnor | [email protected]
103 Souvenir Souvenir 104 Abstract: A wide range of drug delivery technologies are being developed at an astounding rate. The two main compounds that are widely delivered to target areas are various manufactured nanoparticles and medications with poor pharmacokinetic and solubility characteristics. The features of biodegradability and nontoxicity make nano lipid dispersions (liposomes, deformable liposomes, virosomes, ethosomes, and solid lipid nanoparticles) the best colloidal carriers for administration. Solid lipid nanoparticles (SLNs), which may be manipulated to demonstrate a variety of benefits over liposomes and polymeric nanoparticles, are t h e mos t preva l e n t amon g t h em. Du e to t h e ir biodegradability, nanostructured lipid carriers and SLNs are non-biotoxic. They are also quite stable. In this, we address the morphology, structural properties, preparation components, manufacturing methods, and bioavailability enhancementtechniques of these (nanostructured lipid carriers and SLNs). Moreover, even though SLNs and nanostructured lipid carriers are made of lipids and surfactants, their pharmacological importance with regard to innovative techniques, stability, and storage is also highlighted. Keywords:drug, solubility, SLN's, liposomes. SOLID LIPID NANOPARTICLE DESIGN, DEVELOPMENT, AND EVALUATION FOR IMPROVING THE BIOAVAILABILITY OF CERTAIN ANTI-HYPERTENSIVE MEDICATIONS ICLTIPB/PH/2023/10134 Neeraj Chauhan, Anuj Malik M.M College of Pharmacy, Mm University, Mullana, Ambala [email protected] Abstract: Depression is a state of low mood and aversion to activity that can affect a person's thoughts, behavior, feelings and sense of well-being. Depressed people may feel sad, anxious, empty, hopeless, worried, helpless, worthless, guilty, irritable, hurt, or restless. They may lose interest in activities that once were pleasurable experience, loss of appetite or overeating, problems in concentrating, remembering details, or making decisions and may contemplate or attempt suicide. The study investigated the effect of the extract on animal models of depression. The preliminary phytochemical analysis of the extracts revealed the presence of alkaloids, tannins, saponins, reducing sugars, terpenoids and sterols, as the possible biologically active secondary metabolites. Oral administration of both the extracts up to 2000 mg/kg did not any signs of toxicity/deaths suggesting LD50 more than 2000 mg/kg. Oral doses of methanolic and hydroalcoholic extracts (100, 200 and 400 mg/kg) and imipramine (15 mg/kg) decreased the immobility periods and percentage of immobility of mice in both the FST and TST when compared to control group, indicating significant antidepressant activity. In the open space swim test, a chronic depression model, extracts at dose of 200 & 400 mg/kg demonstrated significant antidepressant-like effect on the first day of treatment and sustained it throughout the period of drug treatment. Both the extracts decreased immobility time. A day after the 14th day of drug treatment, the antidepressant effect was still significant. Also, the administration of both extracts once daily for 14 days did not affect liver and renal functions as evident from no significant change in SGPT, SGOT, serum total protein, serum albumin and serum creatinine of extract treated animals when compared to control group animals. The antidepressant-like effects of the extract may be due to the interplay of serotoninergic, glycine/NMDA pathways. Keywords: Depression, appetite, phytochemical, SGOT. NMDA. SCREENING OF CALOTROPIS PROCERA ROOTS EXTRACTS FOR ANTIDEPRESSANT AND ANTIANXIETY POTENTIAL IN SWISS ALBINO MICE ICLTIPB/PH/2023/10133 Preeti Sisodia, Ankur Garg Vivek College of Technical Education, Bijnor [email protected] Abstract: Plumbago zeylanica regulates blood sugar, prevents hypertension and tooth decay. Other studies have shown that it has antibacterial as well as antiviral property. Preliminary phytochemical screening of aqueous, ether and methanolic extracts of Plumbago zeylanica was done. Acute and sub-acute toxicity were conducted on twenty four Albino rats, divided into one control (Group I) and three treatment groups viz. aqueous extract (Group II), ether extract (Group III) and methanolic extract (Group IV). For the study of antidiabetic effect of Plumbago zeylanica rats were divided into seven groups (n=6). Diabetes was induced by a single dose of 5% STZ (125 mg/kg, i.p.) after 24 hours fasting. Blood samples were analysed on day 0, 1, 5, 7, 14 and 28. Phytochemical tests showed presence of different kinds of phyto-constituents in aqueous, ether and methanol extract of Plumbago zeylanica leaves. Daily single dose (2.0 g/kg) administration of aqueous extract (A.E.) , ether extract (E.E.) and methanol extract (M.E.) for 28 days of Plumbago zeylanica could not show any significant change in ALT and AST levels in rats. Blood sugar level was found to be decreased on day 28 in groups of rats treated with A.E., E.E. and M.E. of Plumbago zeylanica. The extracts of Plumbago zeylanica could decrease the blood glucose level in diabetic rats in time dependent manner. Keywords:Plumbago zeylanica, albino rats, ALT, E.E. ANTIDIABETIC ACTIVITY AND PHYTOCHEMICAL SCREENING OF PLUMBAGO ZEYLANICA LEAVES EXTRACTS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS ICLTIPB/PH/2023/10135 Nisha, Ankur Garg Vivek College of Technical Education, Bijnor | [email protected] Abstract: Self nano emulsifying drug delivery system (SNEDDS) are anhydrous homogenous liqiud mixture,composed of oil,surfactant, drug and/or cosolvwnts,which spontaneously from transparent nano emulsion (20-2000nm droplets size) upon aqueous dilution with gentle agitation.The present research demonstrates the development and optimization of self-nano emulsifying drug deliver y system of ibrutinib.Ibrutinib is in a class of medication called kinase inhibitor.it works by blocking the action of the abnormal protien that signals cancers cells to multiply. Ibrutinib SNEDDS formulation optimized using three-factor, threelevel Box–Behnken design and the responses of dependent and independent variables fitted to the second-order quadratic equations and statistical validation calculated by analysis of variance. All optimized SNEDDS formulations were characterized for particle size, zeta potential (ZP), refractive index, % transmission, % drug content, transmission electron microscopy, and drug release study. The formulations prepared using Capryol 90, Cremophor RH40, and Transcutol P (40%) indicated close comparison of the results of micromeritic properties of SNEDDS prepared using different carriers. The bulk density was found to be r a n g i n g b/w b u l k d e n s it y from 0. 203 ±0. 2 2 a n d 0.293±0.08g/cm3, and tapped density from 0.224±0.22 and 0.405±0.02g/cm3, respectively. The flow rate was found to be ranging between 4.89±0.55 and 0.84±0.12g/s, angle of repose from 19.36±1.17and 35.15±1.86 (q), and Carr's index from 11.90±0.03 and 35.30±1.35, respectively. In the present study, the optimal SNEDDS formulation showing significant improvement in dissolution profile of SNEDDS loaded with ibrutinib when compared with pure ibrutinib was successfully developed. The SNEDDS readily released the lipid phase to form a fine oil-in-water nano emulsion, with a narrow distribution size. The in vitro dissolution test showed that the SNEDDS had a faster in vitro release rate than the pure ibrutinib with the first-order release mechanism. Thus, the prepared SNEDDS for the delivery of ibrutinib would be a promising dosage form for the treatment of MCL (Mantle cell lymphoma) and CLL ( Cronic lymphocytic leukemia). Keywords: Self nano emulsifying drug delivery system (SNEDDS), Ibrutinib,MCL (Mantle cell lymphoma)and CLL ( Cronic lymphocytic leukemia). DEVELOPMENT AND OPTIMIZATION OF SELF- NANO EMULSIFYING DRUG DELIVERY SYSTEM OF IBRUTINIB ICLTIPB/PH/2023/10136 Rajat Chauhan RV Institute of Pharmacy, Bijnor | [email protected]
105 Souvenir Souvenir 106 Abstract: Herbal cosmeceutical are used to enhance the human appearance and care too. The main objective of the present research work was to formulate the herbal multipurpose cream which have humidifying, nourishing, whitening, cleansing, enhancing and altering appearance, skin protection against bacterial, treat fungal infections & treatment of various diseases of the skin. Different crude drugs; Aloe barbadensis (Aloe Vera), Tagetes erecta (Marigold ), Azadirachta Indica (Neem-leaves), Curcuma longa (Turmeric-rhizomes), (Lemon juice), Moringa Oleifera (Moringa), Oliumrosae(Rose Oil), mentha Oil, castor oil were taken. The cream was prepared by using fusion method for geometric and homogenous mixing of all the excipients and the herbal extracts. By using this method, we have developed four batches of our herbal cream, namely F1H, F2H, F3H and F4H. All the formulation were estimatedby means of different parameters like appearance, pH, viscosity, phase separation, spreadability, skin irritation test etc. Results: All the formulations showed good appearance, PH, adequate viscosity and no phase separation, good spreadability and no irritation was observed. Also, the formulations showed no redness, erythema and irritation during irritancy study and they were easily washable. All the formulations were stable at room temperature. Conclusion: All four herbal formulations showed significant activities. Based on the results, we can suggest that F2H formulation qualified the mentioned parameretrs and amongst the best of all formulations. Now we are focusing on further studies on the desired formulation. Keywords: Multi-Purpose Cream , Skin Care , Moringa ,Turmeric , Aloevera , Castor Oil. FORMULATION AND STANDARDIZATION OF HERBAL EXTRACT CONTAINING MULTI-PURPOSE CREAM ICLTIPB/PH/2023/10138 Rahul Kumar Pandey, Shivangi Kesharwani Aditya College of Pharmacy Satna M.P. [email protected] Abstract: Currently, hypercholesterolemia is one of the leading problems associated with various diseases worldwide. It is a disorder related to lipoprotein metabolism resulting and increasing blood low density lipoprotein cholesterol level leading to enhance the risk of cardio disease such as heart attack, atherosclerosis hypertension etc, Now a day, many medicine are used to treat this condition but these causes several types of side effects like loss of memory, skin itching, stomach upset, bloating. That's whys we have chosen the herbal pathway to minimize these side effect. This research work focuses on the efficacy and safety of effective herbal medicines in the management of hypercholesterolemia. We prepared four poly-herbal powder formulation containing different herbal extracts such as gauva, methi, amla, garlic, ginger etc. This formulation was done at a laboratory scale and evaluated number of parameters such as density, porosity, angle of repose, pH, colour, odour, etc, and further studies will be done on these formulation. Keywords: Hypercholesterolemia, Lipoprotein, Atherosclerosis, Poly-herbal, Heart attack. PREPARATION AND STANDARDIZATION OF POLYHERBAL POWDER FOR THE MANAGEMENT OF HYPERCHOLESTROLEMIA DISEASE ICLTIPB/PH/2023/10137 Ankita Patel, Karuna Singh, Shivangi Keshrwani Aditya College of Pharmacy, Satna M.P. [email protected] Abstract: Biodiversity refers to the variability of life on earth simply it refers to the variety of plants and animals found on earth. It measures the variations at ecosystem, species and genetic levels. It is believed that an area with higher species abundance has a more stable environment compared to an area with lower species abundance. We can further claim the necessity of biodiversity by considering our degree of dependency on the environment. We depend directly on various species of plants for our various needs. Similarly, we depend on various species of animals and microbes for different reasons. Biodiversity is being lost due to the loss of habitat, over-exploitation of resources, climatic changes, pollution, invasive exotic species, diseases, hunting, Industrialization, Urbanization etc. Since it provides us with several economic and ethical benefits and adds aesthetic value, it is very important to conserve biodiversity. Biodiversity conservation refers to the protection, upliftment, and management of biodiversity in order to derive sustainable benefits for present and future generations. Biodiversity conservation is the protection and management of biodiversity to obtain resources for sustainable development. Main objectives of Biodiversity conservation efforts are, To preserve the diversity of species, Sustainable utilization of species and Ecosystem, To maintain life-supporting systems and essential ecological processes. It can be conserved broadly in two ways: In-situ Conservation & Ex-situ Conservation. Biodiversity conservation is the primary need of the Time for a sustainable Future. Keywords: Biodiversity, Environment, Ecosystem, Conservation, Sustainable BIODIVERSITY CONSERVATION AND ENVIRONMENTAL PERSPECTIVES: A GEOGRAPHICAL ANALYSIS ICLTIPB/PH/2023/10139 Jai Prakash Sharma Department of Geography, University of Kota, Kota, (Raj.) [email protected] Abstract: The demand for new policies in the pharmaceutical industry has increased in recent years due to various factors such as rising healthcare costs, increasing prevalence of chronic diseases, and the need for more affordable and accessible medicines. New policies are needed to address these challenges and improve the overall efficiency, safety, and effectiveness of the pharmaceutical industry. One key area of focus for new policies is drug pricing. The high cost of drugs has become a significant barrier to accessing healthcare, particularly for individuals with low incomes and those living in developing countries. New policies are needed to ensure that drug pricing is fair and affordable, while still allowing for innovation and investment in research and development. Another area of focus is drug safety and efficacy. The pharmaceutical industry has been under increasing scrutiny in recent years for issues related to drug safety, including the opioid epidemic in the United States. New policies are needed to improve drug safety, such as increasing transparency in clinical trials and strengthening post-market surveillance of drugs. In addition to these areas, new policies are also needed to address issues related to intellectual property rights, drug approvals, and access to medicines in developing countries. Overall, there is a growing demand for new policies in the pharmaceutical industry to ensure that medicines are safe, effective, and affordable for all individuals who need them. Keywords: Policy, Pharmaceutical Industry, Developing Countries, Healthcare DEMAND OF NEW POLICIES ON PHARMACEUTICAL INDUSTRY ICLTIPB/PH/2023/10140 Sangeeta Mathur School of Arts & Humanities, Career Point University, Industrial Area, Kota, 324005 [email protected]
107 Souvenir Souvenir 108 Abstract: Butea monosperma, commonly known as "flame of the forest", belongs to the Fabaceae family. It is widely used in traditional medicine. Among its different parts, the flower is the one that is associated with several pharmaceutical effects and antibacterial activity. This study observed the effect of Butea monosperma flower extract (BMFE) on grampositive and gram-negative bacteria. In order to identify the presence of active compounds in BMFE, qualitative test were conducted. Alkaloids, triterpenoids, and flavonoids were specifically targeted in these tests. The minimum inhibitory concentration (MIC) value was measured by broth microdilution method using soyabean casein digest medium on 96 well plates. The bacterial species tested included Staphylococcus aureus, Staphylococcus epidermis, Bacillus pumilus, Bacillus subtilis, Micrococcus luteus, and Escherichia coli. The qualitative tests on BMFE indicated the presence of active compounds such as alkaloids and flavonoids that might responsible for the antibacterial activity of Butea Monosperma. The MIC value of BMFE was 2mg/ml against all species of bacteria tested. BMFE showed the post-antibiotic effect against all the species up to2 hours at 4x MIC. BMFE was found to contain alkaloids and flavonoids that might be responsible for it antibacterial effects against S. aureus, S. epidermidis, B. pumilus, B. subtilis, M. luteus, and E. coli. Further studies will be needed to ascertain the possible mechanism of action of antibacterial effects of BMFE Keywords:Dhak, Palash, Minimum inhibitory concentration, Post-antibiotic effect PHYTOCHEMICAL ANALYSIS AND ANTIBACTERIAL PROPERTIES OF BUTEA MONOSPERMA ICLTIPB/PH/2023/10142 Mohit Agrawal, Sachin Kumar Department of Pharmacology, DIPSAR, Delhi Pharmaceutical Sciences and Research University, New Delhi-110017, India [email protected] Abstract: Pharmacy is an essential component of healthcare, with the primary aim of ensuring that patients receive appropriate medications that improve their health outcomes. However, the provision of pharmaceutical services is not solely limited to dispensing and managing medication, as it also encompasses policies and practices that address various social determinants of health. Social policies in pharmacy refer to the regulations, strategies, and initiatives that are implemented to address social factors that impact patients' health, such as access to healthcare services, socioeconomic status, and cultural factors. One of the most crucial social policies in pharmacy is medication affordability. The cost of medications can be a significant barrier to accessing healthcare services, particularly for individuals with limited financial resources. Therefore, several policies have been introduced to address this issue, such as drug formulary lists, medication discount programs, and drug price controls. For instance, some governments have established programs to subsidize the cost of medications for patients who cannot afford them. Therefore, pharmacy policies have been implemented to promote health literacy among patients, such as providing written and verbal medication instructions, organizing health education programs, and developing easy-to-understand medication packaging. Cultural competence is also a vital social policy in pharmacy. Cultural factors, such as language barriers and religious beliefs, can significantly impact medication adherence and health outcomes. Therefore, pharmacists are trained to provide culturally competent services, which involve understanding and respecting patients' cultural backgrounds, beliefs, and values. This policy can be implemented by hiring a diverse workforce, providing cultural competency training, and using interpretation services. In conclusion, social policies in pharmacy play a crucial role in addressing social determinants of health and improving patients' health outcomes. Policies that promote medication affordability, health literacy, and cultural competence are essential in ensuring that patients receive equitable pharmaceutical services. Therefore, it is imperative to continue developing and implementing social policies in pharmacies that address the evolving social factors that impact patients' health. Keywords: Hypercholesterolemia, Lipoprotein, Atherosclerosis, Poly-herbal, Heart attack. SOCIAL POLICIES IN PHARMACY ICLTIPB/PH/2023/10141 Reeta Saxena School of Arts & Humanities, Career Point University, Kota | [email protected] Abstract: Amino benzothiazoles constitute an important class of compounds. The small and simple benzothiazole nucleus is present in compound involved in research aimed at evaluating new products that possess biological activities such as anti-tumor, anti- microbial, anti-inflammatory. Some new 2 amino- substituted benzothiazole were synthesized , Structures of the synthesized compounds were established on the basis of melting point, TLC, HNMR and IR spectral data. The versatile and synthetically accessible 2-amino benzothiazole scaffolds are quite fascinating for multiple application in both synthetic organic chemistry and biological fields. 2- amino benzothiazole significantly serves as a reactant or a reaction intermediate for affording various fused heterocycles since NH2 and endocyclic N function of 2-aminobenzothizole are suitable to assist reaction with common bis electrophilic reagent to form a diverse fused heterocyclic scaffold. A series of some novel 2-amino benzothiazole derivatives will be synthesized and evaluated for medicinal activities. Biological activity will be focused on Anti-inflammatory activities. Keywords: Benzothiazole, heterocyclic, biologically, derivative. SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY OF 2- AMINO BENZOTHIAZOLE ICLTIPB/PH/2023/10143 Vijay Tambe, Priyanka Mathur Bhagwant University, Ajmer. | [email protected] Abstract: In the present era, acquired HIV (Human Immunodeficiency Virus) is the most fatal disorder for which no completely successful chemotherapy has been developed so far. A variety of anti-HIV agents rely on inhibition of key enzymes involved win the virus life cycle. Over 20 antiretroviral medications have now been approved for the treatment of HIV infected individually. The current there against the human immunodeficiency virus type 1 (HIV-I), which is the etiological agent of Acquired Immune Deficiency Syndrome ( A I D S ) , i s b a s e d o n s i x o f c a t e g o ri e s d r u g s ; nucleoside/nucleotide, reverse transcriptase inhibitors, non nucleoside reverse transcriptase inhibitors, protease inhibitors, cell entry inhibitors and oc-receptor inhibitors. The available drug in the market have only limited or transient clinical benefit due to their side effects and development of drug resistant viral strains. Keywords:Acquired, drugs, transient, strains. HIV ACTIVITIES OF 2-AMINO BENZOTHIAZOLE ICLTIPB/PH/2023/10144 Uday Suryawanshi, Priyanka Mathur Bhagwant University, Ajmer. | [email protected]
109 Souvenir Souvenir 110 Abstract: This research paper aims to explore the role of Urmila, a relatively lesser-known character in the epic Ramayana, in shaping the destiny of Ayodhya. Urmila is the daughter of King Janaka of Mithila and Queen Sunayana and the younger sister of Sita. She was married to King Dasharatha's third son, Lakshmana. They had two sons - Angad and Chandraketa. She is described as devoted to Sita as Lakshmana is to Rama. According to some folk tales, she also gave birth to a daughter named Somada. Through an in-depth analysis of her character, this article examines the politics and power dynamics prevalent in ancient India and their influence on the Ramayana narrative. Urmila's character is explored in the context of the patriarchal society she lived in and the societal expectations placed on women. The study draws on a range of literary sources, including Valmiki's Ramayana, to provide a nuanced understanding of Urmila's character and her contribution to the larger themes of the epic. The results of this research offer valuable insights into the role of women in ancient Indian society and their influence on political and power dynamics. It examines how her actions and sacrifices affected the course of events in the epic and the fate of Ayodhya. The research also examines the implications of Urmila's character for the role of women in ancient Indian society and their impact on political and power dynamics. The results of this research offer valuable insights into the role of women in ancient India and their contribution to shaping political and power dynamics. The study provides a new perspective on Urmila's character, highlighting the importance of her sacrifices and the impact they had on the outcome of the epic. Ultimately, this research contributes to a deeper understanding of the Ramayana's cultural and social context and its enduring relevance in contemporary society. Keywords: Ramayana, destiny, politics, power, women, culture, ancient India. URMILA'S ROLE IN SHAPING THE DESTINY OF AYODHYA: AN ANALYSIS OF HER CHARACTER IN THE CONTEXT OF POLITICS AND POWER DYNAMICS IN ANCIENT INDIA ICLTIPB/PH/2023/10146 Neeta Audichya School of Arts & Humanities, Career Point University, Kota [email protected] Abstract: Regulatory affairs play a crucial role in the pharmaceutical industry and are incorporated in all stages of drug development. Approval criteria practices were developed as a resolution of the government's desire to create policies to protect public health by controlling the safety and efficacy of merchandise in areas including pharmaceuticals, complementary color medicines, veterinary medicines, medical devices, and even food products and cosmetics. Herbal health products are in practices in all parts of the world under either their legal system's or expert council's or agencies' guides. They include botanicals, health supplements, health foods, complimentary medicines, traditional medicines or following pathies like Ayurveda, Yoga, Unani, Siddha, and Homeopathy. The requisite parameters for registration or recognition of products by various major global regulatory agencies were reviewed, and compiled under purview. In India, licensing these products is under the act provisions and the rules known as the Drugs and Cosmetics Act, whereas globally regulatory provisions follow the guidelines of developed countries like the U.S. Food and Drug Administration, European Medicines Agency, the Therapeutic Goods Act, or the World Health Organization's regulations for herbal products. The present communication highlights the provisions of regulatory and/or licensing requirements related to corporates, product composition, specifications, quality parameters, manufacturing methodology, stability, safety, preclinical studies, clinical studies, etc. for herbal products and the respective guidelines at one site. Highlights: Ultimately, all regulatory agencies across the world highlight majorly the safety and thereafter the efficacy for any products under the category. Keywords: Efficacy, legislation, quality, safety, traditional medicines LEGAL REGULATIONS OF TRADITIONAL MEDICINES IN INDIA ICLTIPB/PH/2023/10147 Anjali Dixit School of Legal Studies & Governance, Career Point University, Kota, Raj. [email protected] Abstract: The Anxiety disorders are becoming common in ageing society throughout the world. The clinically used ant-anxiety drugs suffers from disadvantage of side effects and high cost of treatment .Alternative to these drugs are traditional medicines and natural products , which offers a great hope in the identification of bioactive lead compounds and development into drug treating anxiety this results in increased interest in herbal drugs that have the ability to treat anxiety are being explored using experimental animal models (the elevated plus maze, the light and dark test, the open field test, and the social interaction test in mice). The dose of extract of the Sanjeevani plant was chosen at 250, 500, or 1000 mg/kg in accordance with OCED guidelines. Diazepam [0.5mg] was employed as the reference dose. During determination of results, The Animals was scrutinized for behavioral changes before and after drug pretreatment to determine the level of stress induced by experimental model in control, treated and standard group of used animals the drug shown reduction in stress induced by experimental model was considered anxiolytic.Additional research is needed to pinpoint the phytoconstituents and anxiolytic mechanism behind the Sanjeevaniextract's reported central effects. Keywords:Anxiety, drugs, plus maze, stress, central effects. ANXIOLYTIC ACTIVITY OF SANJEEVANI BRYOPTERIS USING EXPERIMENTAL ANIMAL MODEL ICLTIPB/PH/2023/10145 Aayushi Tyagi, Dr. Anurag chaudhary Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Meerut- 250005 (U.P.), India. [email protected] Abstract: Emulgel is emphasized as an advanced leading form of topical medication delivery system. It is the combination of two different formulations that is emulsion and gel. The emulgel formulation possesses the dual control drug release mechanism and along with it is also capable to deliver the hydrophobic drug as well, simply by incorporating the hydrophobic drug into the oil phase of the emulsion. It's used in the treatment of skin diseases. Enhances the bioavailability of the drug to the affected site, enhanced patient compliance, pleasing transparent appearance, provides an emollient effect, bypasses the first-pass metabolism, and capable to overcome the limitation that is associated with the conventional methods of topical drug administration like greasiness, low spreadability, slow drug release, stickiness, staining problem, unable to deliver the hydrophobic drugs, poor patient compliance. Examples of some conventional drug delivery systems are ointment, lotion, gel, and cream. The preparation of the emulgel involves the incorporation method, in which both the emulsion and the gel phases are separately prepared and ultimately emulsion incorporate into the gel phase. The evaluation parameter for emulgel formulation is spreadabi l it y, drug content determination, pH determination, physical examination, ex-vivo permeation study, and extrudability. It is used in the treatment of several skin problems like psoriasis, acne, atopic dermatitis, alopecia, eczema, rosacea, urticaria, etc. The topical drug delivery via emulgel formulation has shown significant improvement in the treatment of various skin diseases (psoriasis, atopic dermatitis) and other skin problems (acne, rosacea). Emulgel formulation effectively overcomes the problems associated with the conventional drug delivery system for topical administration of the drug. It improves the spreadability, delivers the hydrophobic drug, and also has dual control drug release mechanism. Keywords: Emulgel, Drug Delivery, Cosmeceuticals, Skin disease, Formulation EMULGEL FORMULATION- AN EFFECTIVE APPROACH FOR TREATMENT OF SKIN DISEASES ICLTIPB/PH/2023/10148 Anjali Jain, Prashant Kumar Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad [email protected]
111 Souvenir Souvenir 112 Abstract: There has been a lot of interest in plant-based pharmaceuticals in recent years. Rather than novel formulations, emerging plant-based medicine research has concentrated on biological active phytoconstituents. Such medications have been used to treat medical diseases from ancient times, and only the observed symptoms were used to evaluate dosage accuracy, dose effectiveness, and therapy. Yet, in recent decades, researchers have made remarkable success in developing "Novel Drug Delivery Systems" (NDDS) to increase therapeutic efficacy and reduce unwanted effects of bioactive compounds. Nanocapsules, polymer micelles, liposomes, nanophytogels, phytosomes, nanoemulsions, transferosomes, microspheres, ethosomes, injectable hydrogels, polymeric nanoparticles, herbal metal nanoparticles, dendrimers, and other new therapeutic formulations have all been created using bioactive chemicals and plant extracts. Nanotechnology is one of the most important novel drug delivery methods under investigation, with nanoformulations thought to have a wide range of advantages over conventional plant constituent preparations, including increased permeability, solubility, bioavailability, therapeutic activity, stability, improved distribution within tissues, and sustained drug delivery. Nanotechnology also allows for the detection of illnesses at much earlier stages, such as the discovery of hidden or overt metastatic colonies in patients with breast, lung, colon, prostate, and ovarian cancer. Yet, the long-term safety and impacts of nanoformulations must not be neglected. The current study summarises previous research as well as the development of novel formulations, with an emphasis on herbal bioactive components. Keywords: Nanoformulation, Herbal metal Nanoparticles, Polymeric Nanoparticles. NANOFORMULATIONS APPROACH FOR IMPROVED STABILITY AND EFFICACY OF HERBAL DRUGS ICLTIPB/PH/2023/10150 Deepika Aggarwal, Kamal Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra [email protected] Abstract: Thioglycolic acid is used as an antioxidant and stabilizer in pharma cuticles to enhance the stability of main drug and prolong the validity period of pharmaceutical preparations. Thioglycolic acid is used as a metal surface treatment agent. A survey of literature reveals that thioglycolic acid should be an excellent stabilizer for hydrazine derivatives for fatty substance against oxidative deterioration and for aldehydes against auto-oxidation. Thioglycolic acid is highly toxic. Its toxic effect may be related to the special effect of sulfhydryl group of some enzymes. Keywords: Oxidant, excellent, hydrazine, Auto-oxidation, toxic. THIOGLYCOLIC ACID AS STABILIZER ICLTIPB/PH/2023/10149 Rakhi Methi, Priyanka Mathur Bhagwant University, Ajmer. |[email protected] Abstract: Computer science's field of artificial intelligence (AI) gives machines the ability to function effectively and analyse complex data. A cutting-edge idea at the moment, artificial intelligence (AI), has the potential to enhance humankind's standard of living. The study of biological processes and artificial intelligence are increasingly linked, and techniques for obtaining and using the knowledge held in living things are continually improved. It focuses on creating intelligent modelling, which aids in decision-making, problem-solving, and knowledge envisioning. With the development of AI technology, the scientific community may see quick and affordable medical and pharmaceutical research as well as better public services. Artificial intelligence and biological research are increasingly entwined, and techniques for obtaining and using the data held in living things are always being improved. Several Artificial Neural Networks (ANNs), such as Deep Neural Networks (DNNs) or Recurrent Neural Networks (RNNs), are used in the creation of drug delivery formulations. The effectiveness of the technology in quantitative structure-property relationship (QSPR) or quantitative structure-activity relationship (QSAR) analysis h a s b e e n ex a m i n e d i n s eve r a l d r u g d i s c ove r y implementations. Artificial intelligence is being used in pharmacy and bioscience to advance clinical trials and data analysis, quicken the process of developing new drugs and other healthcare innovations, increase diagnostic precision, lower human error rates, and support initiatives for individualised medicine, such as prescribing drugs based on DNA. A number of industries, including drug discovery, personalised medicine, gene editing, radiography, image processing, medication management, disease diagnosis, digital therapy, tailored treatment, drug development, and epidemic or pandemic forecasting, are currently using AI. Deep learning and neural networks were used to forecast the emergence of COVID-19, Zika, Ebola, and seasonal flu. Keywords: Artificial intelligence; clinical trial; disease diagnosis; drug discovery; epidemic, Artificial neural network, Drug discovery, Drug delivery research, Hospital pharmacy. ARTIFICIAL INTELLIGENCE IN PHARMACY AND BIOSCIENCE ICLTIPB/PH/2023/10151 Munajir Rajja, Ashima Shibu, Payal School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur, Rajasthan, India-302017 [email protected] Abstract: Herbalism is a traditional medicine or folk medicine system based on the collection of plant parts such as a plant's leaves, roots, stems, and berries or fruits. These crude plant products are used in the management of chronic as well as acute infections. The purpose of the study is to the wound healing activity related to inflammation with the gel of croton bonplandianum Croton bonplandianum is widely used as a traditional ayurvedic medicine all over India, South Africa and Asia for treating different health disorders. The Herb is known as ban tulsi, jungle tulsi, etc. A wound is a disruption of tissue's cellular, anatomical, and integrity physical, chemical, electrical, or microbial threats to the tissue. Wound healing refers to the body's replacement of destroyed tissue with living tissue. It can be achieved by two processes such as tissue regeneration and scar formation. During healing, a complex cascade of cellular events occurs to achieve resurfacing, reconstitution and restoration of the tensile strength of injured tissue. A gel containing an ethanolic and aqueous ex tract of the dried leaves of croton bonplandianum. As leaves constitute beta-sitosterol the combination of β-sitosterol and naringenin exerted a synergistic effect on wound closure without decreasing the viability of fibroblasts, increasing the antioxidant defence mechanism and decreasing IL-β. The combination that produced the best closure rate namely β-sitosterol with naringenin increased SOD activity significantly and phytochemicals mainly alkaloids, saponins, tannins, glycosides, phenols and carbohydrates repair the collagen fibre. C. bonplandianum is rich in biopolymers, including cellulose, hemicellulose, and lignin. Preliminar y investigation with the new compound shows potent activity for wound healing activity. Keywords:Herbalism, gel, asia, , traditional medicines. A REVIEW: THERAPEUTIC POTENTIAL OF FLAVONOID AND EVALUATION OF HERBAL GEL FOR WOUND HEALING ICLTIPB/PH/2023/10152 1 2 Devangi Solanki , Abhishek Kumar Ojha 1 2 Lloyd Institute of Management And Technology , | Gla University, Mathura [email protected]
113 Souvenir Souvenir 114 Abstract: The present paper deals with the investigation on comparative physico-chemical and phytochemical screening of five medicinal plants viz., leaves of Gymnema sylvestre, fruits of Momordica charantia, rhizomes of Curcuma longa, seeds of Eugenia jambolana and fruits of Embilica officinalis widely used in the treatment of diabetes. In the present communication comparative results were shown. Various macroscopic, physicochemical and phytochemicals parameterswereanalysedandwerepresented. Keywords: Medicinal Plants, Screening, Diabetes. COMPARATIVE STUDY OF PHYSICO-CHEMICAL AND PHYTOCHEMICAL SCREENING OF SOME SELECTED ANTIDIABETIC MEDICINAL PLANT ICLTIPB/PH/2023/10154 Monika Pandey Career Point School of Pharmacy, Career point University, Kota. [email protected] Abstract: Antibiotic resistance is a serious health problem worldwide in which microorganisms (viz. bacteria, viruses, and other parasites) develop resistance against antibiotics. Overuse of antibiotics is a major cause of antimicrobial drug resistance. Research groups are continuously developing new drug molecules to fight against these resistant microbial strains. 1,3,4-oxadiazole is a five-membered ring consisting of two nitrogen and one oxygen atoms. Reported data indicated that 1,3,4-oxadiazole derivatives showed antidiabetic, analgesic, anti-inflammatory, anticancer and antimicrobial activities. Bond angle, polarity, steric, electrostatic, Hbonding and flexibility of 1,3,4-oxadiazole moiety helps in the modification and improvement of the antimicrobial activity of target molecules. The present review summarizes the SAR and therapeutic targets of 1,3,4-oxadiazole derivatives as an antimicrobial agent. Antimicrobial potential of 1,3,4- oxadiazole derivatives was analyzed on the basis of inhibition of targets viz. DNA gyrase enzyme. The present study indicated that substitution of thion, quinoline, benzothiazole and benzimidazole moieties on the 2nd and 5th positions of 1,3,4-oxadiazole improved the antimicrobial activity. Further, literature survey showed that 1,3,4-oxadiazole derivatives showed potent antimicrobial activity by inhibiting the DNA gyrase enzyme. It is hoped that these findings will be helpful for the researchers to develop rational designs of more active 1,3,4-oxadiazole compounds as antimicrobial agents. Keywords: 1,3,4-Oxadiazole, Antimicrobial drug resistance, enoyl acyl carrier protein reductase 1,3,4-OXADIAZOLE DERIVATIVES AS ANTIMICROBIAL AGENT VIA DNA GYRASE INHIBITON ICLTIPB/PH/2023/10153 Pankaj Gupta, Sangeeta Verma, Rakesh Narang, Sukhbir Lal Institute of Pharmaceutical Science, Kurukshetra University Kurukshetra (Haryana) [email protected] Abstract: Antimicrobial drug resistance is the main problem to control worldwide infectious diseases. In 2019, WHO reported 32 antibiotics (under clinical trials) in the list of priority against microorganisms. From this list only 6 antibiotics are innovative, the remaining were derived from previously known chemical moieties. Quinoline is a well-known natural occurring moiety showed antibacterial activity by inhibiting the DNA gyrase enzyme (e.g., fluoroquinolones). However, studies showed that mutations are occurring in the structural genes of this enzyme against quinolones. Therefore, efforts are required to develop novel drugs, which can act against new microbial targets. Bedaquiline is a novel USFDA approved quinoline-based antitubercular drug, which inhibits ATP synthase enzyme rather than DNA gyrase. Amongst various reported activities, the antibacterial activity of quinoline hydrazide/hydrazone derivatives is noteworthy. The aim of present study was to emphasized the antibacterial activity of quinoline hydrazide/hydrazone derivatives. Antibacterial potential of quinoline hydrazide/hydrazone derivatives were analyzed on the basis of substitution of hydrazide/hydrazone moiety at different positions of quinoline ring. Review of reported data indicated that electronegative groups containing aryl substitutions with hydrazide/hydrazone moiety at the 3rd and 4th positions of the quinoline improved the antibacterial activity against various bacterial strains. Quinoline hydrazide/hydrazone derivatives showed antibacterial activity by inhibiting DNA gyrase, glucosamine-6-phosphate synthase (G6PS), enoyl ACP reductase and 3-ketoacyl ACP synthase enzymes. It is hoped that this finding will be helpful for the researchers to develop rational designs of more active quinoline-based hydrazide/hydrazone compounds as antibacterial agents. Keywords: Quinoline hydrazide/hydrazone, DNA gyrase, ATP synthase QUINOLINE HYDRAZIDE/HYDRAZONE DERIVATIVES: ANTIBACTERIAL POTENTIAL, STRUCTURE ACTIVITY RELATIONSHIP AND MECHANISM OF ACTION ICLTIPB/PH/2023/10155 Sangeeta Verma, Sukhbir Lal, Rakesh Narang Institute of Pharmaceutical Science, Kurukshetra University Kurukshetra, Haryana [email protected] Abstract: Combined Alogliptin with Metformin is a common way to treat type 2 diabetes patients with high blood sugar. This study's primary goal was to establish an organic impurities method which is rapid, accurate and precise reversed-phase high performance liquid chromatographic (RP-HPLC) approach that could determine the organic impurities in Metformin and Alogliptin combination drug product. The procedure involves separating the two drugs and organic impurities in reversed-phase mode using a Water C18 250 4.6 mm, 5 column that is kept at room temperature. Acetonitrile: Ammonium Phosphate buffer pH 3.5 (70:30 v/v) was the ideal mobile phase mixture, with a flow rate of 1.0 mL/min, and VWD detection at 214 nm. ICH guidelines were followed in the method's validation. With correlation values of 0.998 and 0.999, respectively, Alogliptin and Metformin showed linearity in the concentration ranges of 6.25-18.75 g/mL and 250-750 g/mL. With an RSD of less than 2.0%, the mean percent recovery of triplicate samples at each level for both medicines was determined to be between 98 and 100 percent. For Metformin and Alogliptin, the standard calibration curve was established in the concentration range of 500 g/mL and 12.5 g/mL, respectively. Metformin's percent of label claim was determined to be 100.48 and Alogliptin's percent to be 100.11. The established HPLC method's validation is linear, accurate, precise, particular, and robust. It is a time- and cost-saving technique with several uses in quantification, routine analysis, forced degradation research, stability investigations, and other fields. Keywords: Alogliptin, Metformin, Organic Impurities, RPHPLC, Validation, ICH, Quality Control Analysis EFFICIENT METHOD FOR DETERMINATION OF ORGANIC IMPURITIES IN ALOGLIPTIN AND METFORMIN DOSAGE FORM BY USING RP-HPLC ICLTIPB/PH/2023/10156 1* 2 3 Pradeep Swarnkar , Mahesh Kumar Gupta , Monika Maheshwari 1 2 Kota college of Pharmacy, Kota, Rajasthan | Career Point University, Kota 3 Geetanjali Institute of Pharmacy, Geetanjali University. [email protected]
115 Souvenir Souvenir 116 Abstract: Even though there is frequently little or no solid scientific evidence to support it, off-label drug use is fairly common in medical practice. In addition to doctors and pharmaceutical corporations, regulatory bodies and patients are also involved in off-label use of medication. Without off-label prescribing, therapeutic options may be limited for some patient populations. For patients with rare diseases, where it may occasionally be the sole medication, off-label applications can be helpful. When a medicine can enhance the quality of life, it may be appropriate to allow its promotion for off-label applications (e.g., same or better outcomes at lower cost). Although there are several disagreements, experts generally concur that more needs to be done to improve access to appropriate off-label medications for patients with rare and other disorders. It is crucial to be aware that the FDA must receive clinical data and other information from a company before a medicine can be approved. The manufacturer of the drug must demonstrate that it is both effective and safe when used as directed. A medicine being "safe" does not imply that it has no side effects. In its place, it indicates that the FDA has decided the advantages of using the medicine for a certain purpose exceed the possible hazards. Keywords: FDA, medication, crucial, populations, pharmaceutical. Have You Know About off label use of drug? ICLTIPB/PH/2023/10158 Ved Prakash Jadaun, Mayank Kulshreshtha Department of Pharmacology, Rajiv Academy for Pharmacy, Mathura (U.P.), India. [email protected] Abstract: With the expansion of research and development in medical technologies, more animals are being employed in research. All throughout the world, millions of experimental animals are utilised each year. Animals' suffering, mortality, and misery during scientific studies have long been a topic of controversy. Animal research has a few other drawbacks outside the main ethical issue, such as the need for trained labor, lengthy protocols, and high expense. To address the problems with animal testing and prevent unethical practices, a number of alternatives have been presented. For the use of animals in laboratories, the three Rs (reduction, refinement, and replacement) are being used as a strategy. This strategy is applied using various techniques and alternative organisms. Up to a point, these techniques offer an alternative way to conduct chemical and drug testing. The advantages of each of these options are briefly described in this review along with some examples. A combined use of these strategies would provide information on how few animals should be used in research. Keywords: Animals, mortality, protocols, reduction, refinement, replacement. Alternatives to Animal Research ICLTIPB/PH/2023/10157 Somya Gupta, Mayank Kulshreshtha Department of Pharmacology, Rajiv Academy for Pharmacy, Mathura (U.P.), India. [email protected] Abstract: Nanostructured lipid carriers (NLCs ) are novel pharmaceutical formulations which are composed of physiological and biocompatible lipids, surfactants and cosurfactants. NLC can be used to deliver the drug through various routes like parenteral, topical and oral routes by controlling the release of administered drug. Several techniques for the production of NLCs are high pressure homogenization, microemulsion, probe sonication, solvent diffusion, solvent emulsification evaporation, solvent injection/solvent displacement, and phase inversion. NLCs can be used in a wide variety of drug delivery systems such as oral drug delivery system, transdermal drug delivery system, injection drug delivery system, and gene transfection. NLCs have been successfully applied to improve effectiveness of bioactive not only at local gastrointestinal tract (GIT), but also at targeting sites such as brain, liver, cancer ulcer. NLCs have better physical stability, controlled particle size, ease of preparation and scale-up, increase of skin hydration and elasticity. However, they have some limitations like drug expulsion, lack of wide clinical applicability. Keywords: NLC's, GIT, drug delivery system, clinical applicability, parenterals. AN OVERVIEW ON NANOSTRUCTURED LIPID CARRIER BASED DRUG DELIVERY SYSTEM ICLTIPB/PH/2023/10159 *1 1,2 1 Preeti Choudhary , Bibhash C. Mohanta , Vaibhav Rastogi 1 Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad (U.P) 2 Department of Pharmacy, Central University of South Bihar, Gaya, Bihar 824236 [email protected] Abstract: The AI technology is used in each step of the drug desingning procedure, which decreases the health hazards related to preclinical trials and also reduces the cost of substantially. The AI is an effective tool for data mining based on the huge pharmacological data and machince learing process. Artifical Intelligence (AI), currently a cutting-edge concept, has the potential to improve the quality of life of human beings. The fields of AI and biological research are becoming more interwined, and methods for extracting and applying the information stored in live orgainisms are constantly being refined. Keywords:AI, health hazards, data mining, cutting edge. ARTIFICAL INTELLIGENCE IN PHARMACY AND BIO-SCIENCE ICLTIPB/PH/2023/10160 Rita Yadav, Anjali Masoom , Aryan Bhardwaj, Sameer Abbas School of Pharmaceutical Sciences, Jaipur National University, Jaipur [email protected]
117 Souvenir Souvenir 118 Abstract: Some Polyherbal formulations containing Tinosporia cordifolia, Moringa oleifera and Allium sativum extracts were evaluated for its anti-inflammatory activity by in-vitro methods. Qualitative analysis of whole plant extract revealed the presence of alkaloid, flavonoid, saponins, steroid, phenol, tannin, glycoside and terpenoid. In-vitro antiinflammatory activity of polyherbal formulations and individual extracts were estimated using antiproteinase activity, albumin denaturation assay, and antilipoxygenase activity at different concentrations. The results showed that polyherbal formulation showed significant results in all activities. Inhibition increased mostly with increasing the concentration. In albumin denaturation, Antiproteinase method and Antilipoxygenase assay highest activity is recorded with PHF-1. In vitro antiinflammatory activities were evaluated as the first study of inflammation for seeing the activities of polyherbal formulations. The study concluded that the PHF-1 is potent among all the formulations as it showed a better antiinflammatory activity as compared to other formulations. Keywords: Polyherbal formulation, inflammation, Antiinflammatory activity, In vitro models. ANTI-INFLAMMATORY ACTIVITY DETERMINATION OF A POLYHERBAL FORMULATION CONTAINING TINOSPORIA CORDIFOLIA, MORINGA OLEIFERA AND ALLIUM SATIVUM ICLTIPB/PH/2023/10162 1* 2 Garvita Chaudhary Joshi , Meenakshi Bharkatiya Bhupal Nobles' University, Udaipur (Raj.), India B.N. Institute of Pharmaceutical Sciences, B.N. University, Udaipur (Raj.), India [email protected] Abstract: Syzygium cumini (L.) (Family: Myricaceae) commonly known as Jamun is a widely used medicinal plant in Ayurveda. Syzygium cumini reported to contain tannins, flavonoids, phenols, 7-Hydroxycalamenene, Oleanolic acid, βSitosterol, and Methyl-βorsellinate. The measures taken for pharmacognostic characterization were macroscopy, microscopy, physicochemical evaluation, and preliminary phytochemical screening. The microscopic evaluation showed useful characters for the recognition of leaf of Syzygium cumini (L.). The upper epidermis shows the presence of a single layer of wavy epidermal cells with striated cuticle. Spheraphide is distinctly visible in the lamina region between palisade cells and spongy parenchyma cells. Vascular bundle (Xylem and phloem) were present in the center. Physicochemical studies showed total ash (11.7%), acid insoluble ash (2.7%), alcohol soluble extractive values (5.7 %), and water-soluble extractive values (9.6%). Phytochemical analysis revealed the presence of sugar, lipid, Glycoside, saponins, phenols, flavonoids, tannins, tri-terpenoids and steroids. The present study focused on pharmacognos tic characters and a physicochemical parameter which could be useful for identification and authentication of the plant. Keywords: Syzygium cumini, medicinal plants, epidermal cells, ash values, traditional medicines PHARMACOGNOSTIC AND PHYTOCHEMICAL STUDIES OF LEAVES OF SYZGIUM CUMINI ICLTIPB/PH/2023/10161 Ms. Varsha Yadav, Ms. Prachi Gupta Institute of Pharmacy, P K University, Vill-Thanra,Teh- Karera District -Shivpuri, Madhya Pradesh, Pin-473660 [email protected] Abstract: In this review we discuss the practical aspects of Microneedles these are the innovation in Transdermal Drug Delivery System . Microneedles are recently Advancement in Biomedical science. Microneedles are also known as MicroPatches & Micro-Arrays. These are the tiny needles like structure these are alternative to deliver a Painless treatment to needle phobias these needle improve overall convenience in Vaccine delivery . Microneedles were first mentioned in a 1998 by Mark Prausnitz at the Georgia Institute of Technology that demonstrated that Microneedles could penetrate the uppermost layer(Stratum corneum) of the skin so it is suitable for delivery of transdermal delivery of Vaccine and therapeutic agents. it allow rapid penetration of drug into skin .Microneedles device are used to delivered therapeutic agent for Vaccine ,Growth hormone,Skin Cancer,Insulin. The materials used for fabrication is biodegradable, non-bidegradable, metal,silicone.These MNs is best choice for patient having needle phobia. Microneedle vaccine Technology rapidly developing domestically and internationally and very soon a Microneedle vaccine patch will likely be available through Transdermal drug delivery in these medication delivered with minute pain sensation ,so it is best choice for children and needle phobic patient.it provide self applicable Vaccination approach. Keywords: Microneedles, classification, fabrication needles,method,application , Vaccine MICRONEEDLES: RECENT DEVELOPMENT IN VACCINE THROUGH TRANSDERMAL DRUG DELIVERY SYSTEM ICLTIPB/PH/2023/10163 Tulsi tak, Madhuri Meghwanshi, Abhilasha Shete, Jagdish. C. Nagar Department of Pharmacy, Kota college of Pharmacy [email protected] Abstract: Oral drug delivery is always a simplest and oldest method for drug Administration as compare to other painfull treatment (Injection)for Diabetes management. new researcher (MIT) develope a Capsule Pill for delivery of Insulin to patient for avoid painfull Medication.Delivery of Insulin in Pill form is dream for Diabetes researcher, but after decades of trying there has been some achievements related to these. Type 1 Diabetes always treated by Injection that is painfull treatment and discomfort for Child & patient having needle Phobias. In these delivery sugar coated pill dissolved in body & release Insulin directly to Stomach lining needles release Medicament to Stomach and reach to blood circulation to maintain insulin levels in body. These research are replacement of injection therapy. These needles are made by Biodegradable material to dissolve in body fluid. Keywords: Insulin, Types, Needles Internal structure, Injection, Treatment. RESEARCH OF ORAL PILL DISCOVERY FOR INSULIN DRUG DELIVERY ICLTIPB/PH/2023/10164 Jyoti Nagar, Madhuri Meghwanshi, Jagdish C. Nagar Department of Pharmacy, Kota College of Pharmacy [email protected]
119 Souvenir Souvenir 120 Abstract: Many regions have different levels of prevalence and severity of dermatological factors. The most prevalent skin disorders in growing to adolescent worldwide include dry skin, dyspigmentation, wrinkles, fungal infections, and benign and malignant tumours due to reduced functional ability and increased sensitivity of the skin. The most visible indicator of the general ageing process is its appearance, which also includes changes in cutaneous structure and function. Human skin's appearance and function vary specifically as we age, which is a time-dependent phenomena. To study the role of phenolic compounds in modulating signalling pathways to combat skin ageing. A review includes a search of the databases PubMed, Journal of Elsevier, Springer, Bentham science, Wiley, Scopus, and web of science indexed journals using keywords “Skin ageing, antioxidants, ROS, signalling pathways”. Reactive oxygen species (ROS) are produced rapidly and accumulate in skin cells as a result of UV exposure, which accelerates oxidative stress and skin ageing. A successful technique to combat age-related skin diseases may involve exogenous supplementation with dietary antioxidants and/or skin pre-treatment with antioxidant-based lotions before sun exposure. Phenolic compounds, ascorbic acid, ellagitannins, carotenoids, derived from different plant species, are able to protect the skin by preventing UV penetration, reducing inflammation and oxidative stress, and influencing several survival signalling pathways. We focus on the role of the antioxidants in cell metabolism, environmental factors and xenobiotics agent involved in the skin ageing. Two distinct mechanisms of action for the intervention were described in this exhaustive study. Phenolic compounds showing the antiageing property by modulating the NF-kB signalling pathway, MAPK signalling. Keywords: Ageing, Reactive oxygen species(ROS), Phenolic compounds, Antioxidant, NF-kB signalling pathway, MAPK signalling. ROLE OF PHENOLIC COMPOUNDS IN MODULATING SIGNALLING PATHWAYS TO COMBAT SKIN AGEING ICLTIPB/PH/2023/1066 Swati Shukla, Phool Chandra, Mayur Porwal Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India. [email protected] Abstract: The Management of Nickel contaminated soil and water is a major current environmental issue. The main reason for pollution of the environment with nickel is the use of metal complexes in industry, agriculture and household. Nickel is kept under the environmental pollutant category due to their toxic effects in plants, humans and food. In this research paper a comparative study was carried out to evaluate the adsorption behaviors of different Ni compounds (NiCl2, NiSO4 and NiSO4(NH4)2SO4) in alkaline soil. Soil is used as an adsorbent for Ni (II) removal from aqueous solutions. The experimental results were tested in a batch model analyze adsorption characteristics like PH, amount of adsorbent and initial concentration of metal ion. The change in Ni (II) concentration due to adsorption was determined by the Dimethylglyoxime spectrophotometric method. The optimum results were determined at an initial metal ion concentration of 4 (mg L-1), PH=10, agitation time =14 min. and amount of soil (8 mg/50ml). For quantification analysis all spectral and absorbance measurements were carried out by Visible-spectrophotometer at the wavelength (λ) = 445 nm. This study aims to quantify about the adsorption of Ni on soil is important for evaluating the data of Nickel functioning for farm soil. Keywords: Ni (II), adsorption, Soil, batch experiment, Visible - spectrophotometer. A COMPARATIVE STUDY ON THE EFFECT OF ADSORPTION PARAMETERS OF Ni (II) IN ALKALINE SOIL ICLTIPB/PH/2023/10165 Deepak Hada, Shweta Saxena Department Of Chemistry, Maa Bharti P.G.College Kota, Rajasthan, India [email protected] Abstract: Oxidative stress has a key role in the pathogenesis and progress of diabetic peripheral neuropathy (DPN), the most common and incapacitating complications of diabetes mellitus. Acalypha hispida is a treasure of multiple pharmacological properties and presently leaves of this plant have been explored to evaluate the protective effects against streptozotocin-induced diabetic neuropathy in rat. Male Sprague-Dawley rats were injected with single intra peritoneal injection of streptozotocin (STZ) (60 mg/kg) to develop animal model of diabetes. Post 21 days of STZ induction, animals were treated with ethanolic extract of Acalypha hispida (200 mg/kg and 400 mg/kg of EEAH) for forty two consecutive days. Followed this, all animals were evaluated for the levels of blood glucose, cholesterol (CH), lipid peroxidation (LPO), Catalase (CAT), Superoxide Dismutase (SOD). Neuropathic pain markers like hyperalgesia, allodynia and motor deficits were assessed before and after the treatment with STZ and EEAH. STZ treated rats exhibited elevated levels of blood glucose, CH, LPO, CAT, SOD in comparison to control rats. EEAH treatment significantly decreased blood glucose levels, CH, LPO, CAT, SOD levels, and restored pro-oxidants status. Further, decrease in hyperalgesia and restorative changes following EEAH treatment suggested the neuroprotective potential of Acalypha hispida leaves in diabetic rats. Current study reveals that EEAH exert protective and curative effects against STZ-induced diabetic neuropathy in rats which might be due to its antioxidant, anti-inflammatory, and antiapoptotic properties. Keywords: Alogliptin, Metformin, Organic Impurities, RPHPLC, Validation, ICH, Quality Control Analysis PROTECTIVE EFFECTS OF METHANOLIC EXTRACT OF ACALYPHA HISPIDA LEAF ON STREPTOZOTOCIN INDUCED DIABETIC PERIPHERAL NEUROPATHY IN RATS ICLTIPB/PH/2023/10167 A V Shrirao, N Y Bhiwgade, D S Mohale, P J Wadhwani, N I Kochar, A V Chandewar P. Wadhwani College of Pharmacy, Yavatmal (Maharashtra) India. [email protected] Abstract: Soil and water are indispensable for the existence and survival of all living beings. Healthy soil and availability of water are vital for productivity in all kinds of terrestrial ecosystems as plants require fertile soil with improved biophysio-chemical properties and good quality of water for their growth and development. Anthropogenic activities such as slash-and-burn agriculture, overgrazing, deforestation, mining, and intensive agriculture practices are accountable for accelerated soil erosion. The higher rate of soil erosion has led to the removal of organic matter and plant nutrients from the fertile topsoil and eventually lowering crop productivity. Furthermore, the future of living beings and agricultural production systems is at stake due to continuously depleting aquifers and increasing pressure on underground water under projected climate change scenarios. Henceforth, the burgeoning world population, food insecurity and natural resource degradation are the major issues in the present era of climate change. It has been projected that the world population will be about10 billion by 2050. To cope up with these issues, rapid industrial growth and intensive farming practices are expected to increase the pressure on land and water resources in near future. Therefore, a paradigm shift in soil and water conservation, and its management is needed for agricultural sustainability. Thus, the present article reviews the various mechanical, engineering, structural and biological measures helpful in soil and water conservation. Keywords: Soil, Water, Anthropogenic, fertile, organic matter, sustainability, crops. SOIL AND WATER CONSERVATION FOR SUSTAINABLE AGRICULTURE ICLTIPB/PH/2023/10168 1 2 3 Manisha Sharma , Arti Shah , Saraswati Agrawal 1 Department of Zoology, JDB. Govt. Girls College, Kota 2,3Department of Chemistry, JDB Govt. Girls College, Kota [email protected]
121 Souvenir Souvenir 122 Abstract: The prevalence of obesity and diabetes is on increasing global problem. Tirzepatide is a dual glucose dependent insulinotropic polypeptide and glucagon like peptide receptor agonist , recently approved in united state by food and drug authority in May 2022 to treat type 2 Diabetes. Tirzepatide is reffered to as the twin epidemic and known as TWIN CRETIN. The novel anti diabetic drug is synthetic analog of human GIP hormone with a C20 fatty diacid portion attached which , via acylation technology , can bind to albumin in order to provide a dose of drug , by means of subcutaneous injection , once in a week , which is appropriate to its half life of about five days. Glucose dependent insulinotropic peptide and glucagon like peptide receptor can reduce glycemic level and improve insulin sensitivity as well as reducing body weight average about 20% and improving lipid metabolism. Good patient for tirzepatide are whose who have BMI greater than 30. Nausea , diarrhea , and constipation etc are the side effect of tirzepatide , so the patient should maintain nutrition support and excercise regimen. Keywords: Tirzepatide, Twin c, cretin, Glucagon like peptide, Glucose dependent insulinotropic peptide, Diabetes , Obesity. TIRZEPATIDE NEW ERA OF DUAL TARGATED TREATMENT FOR DIABETES AND OBESITY ICLTIPB/PH/2023/10170 Archi Gupta Department of Pharmacy, University of Kota, Kota (Rajasthan). [email protected] Abstract: For orally administered drugs solubility is the most important one rate limiting parameter to achieve their desired concentration in systemic circulation for pharmacological response.In the present study, an attempt was made to design and evaluate Cefuroxime axetil capsule with the prime objective to convert crystalline form to amorphous which is one of the pre-requisite to enhance the solubility of Cefuroxime axetil and to match or have a better in vitro drug dissolution profile. Cefurxoime axetil prepared by hot melt extrusion of wax, polymer and combination of wax and polymer followed by milling, screening and capsule filling. Various formulations (A1 to A4,B1 to B4 and C1 to C4) prepared containing drug and different combinations of stearic acid, Eudragit E-PO and PVP as a carrier for dissolution enhancement. The results of this investigation can be summarized as Hot melt extrusion can be effectively used as a means of converting a crystalline drug to its amorphous form, Polymers used in this study efficiently serve the purposes they were employed for, namely, assisting in improving the solubility of the drug, acting as impurities to destabilize the rigid crystal structure, and as crystallization inhibitors, preventing reconversion of the amorphous drug to its crystalline form, Stearic acid and Eudragit E-PO shows protracted drug dissolution. PVP was the better polymer among the three used in this study and Capsules prepared from the drug-polymer mixture exhibit supra dissolution profiles. The concept of increasing the solubility by virtue of application of combination of the Povidone C4 was supra formulation. Solubility is prerequisite of bioavailability in prototype C4 formulation; there is significant increase in dissolution which evidence that increases in bioavailability. Keywords: Cefuroxime axetil,Stearic acid, Eudragit E-P0, Povdione. IMPROVEMENT OF SOLUBILITY AND ORAL BIOAVAILABILITY OF CEFUROXIME AXETIL BY HOT MELT EXTRUSION TECHNIQUE ICLTIPB/PH/2023/10169 * S. T. Landge , A.V. Chandewar P. Wadhwani College of Pharmacy, Yavatmal (Maharashtra) India. [email protected] Abstract: Diabetes Mellitus has many chronic complications including Diabetes related Peripheral Neuropathy which causes major impact on peripheral nervous system resulting into increase incidences of fall and socioeconomic burden. AI technologies, such as machine learning and data mining, have been increasingly integrated with medical science and are gradually becoming important drivers of medical development. Artificial intelligence based Neural network model has been used to evolve smart device to replace Neurothesiometer measuring Diabetic Vibration Perception Threshold with improved accuracy. In addition to that similar and enhanced models (AIBased) can give more accurate interpretation to the diabetic patients and healthcare providers to allow them early identification of the symptoms of diabetes related complications like peripheral neuropathy. They can provide real-time, cost-effective and appropriate diagnosis by analysing large data in much lesser time with accuracy and preciseness in diabetic patients resulting early diagnosis and better management of the complications at initial stages. The intersection of advance technologies with conventional knowledge may help to build a patient centric care in the field of diabetes. With the identification of suspected high-risk patients by finding out the prognostic feature of the disease, and developing advanced treatment approaches and protocols, AI based Neural Network Model can play a promising role in the future prospects. Keywords: Diabetic Peripheral Neuropathy, Artificial Inteligence, Health Care, Neural Network Model, Deep Learning. THE ROLE AND FUTURE PROSPECT OF AI-BASED NEURAL NETWORK MODELS IN THE DIAGNOSIS OF DIABETES RELATED PERIPHERAL NEUROPATHY ICLTIPB/PH/2023/10171 Mridula Chauhan Department of Physiotherapy Career Point University Kota, Rajasthan [email protected] Abstract: Tuberculosis (TB) is a contagious infection that usually attacks your lungs. It can also spread to other parts of your body, like your brain and spine. A type of bacteria called Mycobacterium tuberculosis causes it. Latent TB. You have the germs in your body, but your immune system keeps them from spreading. You don't have any symptoms, and you're not contagious. But the infection is still alive and can one day become active. If you're at high risk for re-activation for instance, if you have HIV, you had an infection in the past 2 years, your chest X-ray is unusual, or your immune system is weakened your doctor will give you medications to prevent active TB. Active TB. The germs multiply and make you sick. You can spread the disease to others. Ninety percent of active cases in adults come from a latent TB infection. You're a smoker. A healthy immune system fights the TB bacteria. But you might not be able to fend off active TB disease if you have, HIV or AIDS. Diabetes. Severe kidney disease. Head and neck cancers. Cancer treatments such as chemotherapy. Low body weight and poor nutrition. Those tests don't tell you if your infection is latent or active. If you get a positive skin or blood test, your doctor will learn which type you have with a chest X-ray or CT scan to look for changes in your lungs. Acid-fast bacillus (AFB) tests for TB bacteria in your sputum, the mucus that comes up when you cough. Your treatment will depend on your infection. If you have latent TB, your doctor will give you medication to kill the bacteria so the infection doesn't become active. You might get isoniazid, rifapentine, or rifampin, either alone or combined. You'll have to take the drugs for up to 9 months. If you see any signs of active TB, call your doctor right away. A combination of medicines also treats active TB. The most common are ethambutol, isoniazid, pyrazinamide, and rifampin. You'll take them for 6 to 12 months. If you have drug-resistant TB, your doctor might give you one or more different medicines. You may have to take them for much longer, up to 30 months, and they can cause more side effects. Whatever kind of infection you have, it's important to finish taking all of your medications, even when you feel better. If you quit too soon, the bacteria can become resistant to the drugs. Keywords: Tuberculosis (TB), Multi Drug Reactant (MDR), Acidfast bacillus (AFB), Computed Tomography scan (CT scan). TO OBSERVE AND ISOLATION AND TREATMENT OF MYCOBACTRIUM TUBERCULOSIS ICLTIPB/PH/2023/10172 Gaurav Kamewal, Chetan Kumar Dubey, Abhishek Nagar, M.K. Gupta Department of Pharmacy, Career Point School of Pharmacy, CPU, Kota (raj.) [email protected]
123 Souvenir Souvenir 124 Abstract: Now a day's synthetic drugs are in great demand due to their high medicinal values but they have some side effects. Besides many herbal plants some root vegetables also help in health benefits. Daucus carota were first grown as medicine for an assortment of ailments. Carrots are healthy vegetable that are eaten as snacks. The fiber in carrot can help to control the blood sugar level. Carrots are good source of several vitamins like, A,K1 and B6 and minerals like, biotin, potassium. Carrots' water content capacity from 86-95%. Carrot also help to reduce risk of cancer, lower blood cholesterol, maintain proper diet and eye health. It is reported that the plant has some therapeutic potentials like antioxidant, anti-inflammatory, plasma lipid modification, and anti-tumor properties. Carrot contains important phytochemicals i.e. phenolic compounds, carotenoids, polyacetylenes, and ascorbic acid. Genotype plays an important role like high contents of α and βcarotene are present in orange carrots, lutein in yellow carrots, lycopene in red carrots, anthocyanins in the root of purple carrots, and phenolic compounds in black carrots. Carotenoids and volatile compounds contain an important role in the yield and quality of carrots. When carrot grows in cool conditions, results in a higher yield and quality of carrots, and higher temperatures would increase terpene synthesis, resulting in carrots with a bitter taste. So, for that reason, the plant is called “The Wonderful Tree”. Further research and clinical trials have to be carried out to commercialize the potential pharmaceutical uses of the plant. Keywords: Daucus carota, Polyacetylenes, Anti-tumour, Antioxidant. HEALTH BENEFITS OF DAUCUS CAROTA (CARROT): A REVIEW ICLTIPB/PH/2023/10174 Amrik Dey, Parag Ghosh, Arghya Kusum Dhar School of Pharmacy, The Neotia University, Jhinga, Sarisa, Parganas (South), West Bengal [email protected] Abstract: The term Nutraceutical was derived from 'Nutrition' (a nourishing food or food components) and 'Pharmaceutical' (a medical drug). Nutracentical is a term coined by Dr. Stephan De Felice in 1989. Nutraceutical are continously developed and have quickly spread worldwide. Nutraceutical found possible health benefits and utilized in treatment of several disease such as diabetes, cancer, cardiovascular disease, obesity. From the extensive research revealed that chronic inflammation or disease can be suppressed by use of nutraceutical metabolites derive from fruits, vegetables, which have proven successfully in regulating tumour motabalism and growth. Vitamins also plays an important role in cancer prevention and treatment by DNA methylation and DNA synthesis. Researchers have also focussed on potential effects of citrus fruits in beneficial management of diabetes. Thus unlike citrus fruits many other nutraceutical such as phenolic acids, flavanoids, lignans have potential efficacies in preventing and allivation of metabolic disorder and complication induced by diabetes. Obesity is deposition of unhealthy amount of body fat associated with various risk factor such as diabetes, hypertension. Nutraceutical like glucomannan, G sylvestre and Vitamin C have significant reduced fat and body weight. Nutritional therapy has emerged as new concept of health aid. The consumption of nutraceutical from plant origin has become popular to improve health, prevent and treatment of disease. Nutrraceutical are bioactive compound providing the essential benefits effects beyond basic nutrition. Nutraceutical offering attractiveness not only to the food companies but also the pharmaceutical and biotechnology firms. Here we have gathered several studies highlighting affectiveness of nutraceutical in management of various disease such as cancer, diabetes, obesity. Keywords:Nutraceutical, Disease, Health Benefits, Food. AN OVERVIEW OF APPLICATION OF NUTRACEUTICAL IN HUMAN DISEASE ICLTIPB/PH/2023/10173 Lucky Ali Career Point School of Pharmacy, CPU, Kota, (Rajasthan). [email protected] Abstract: Huntington's disease is a progressive, autosomal dominant neurodegenerative disease which progressively effect brain cell entire over time lead to progressive loss of physical and cognitive abilities. The common pathological cascade of Huntington's disease (HD)is transcription dysregulation, mitochondrial dysfunction, excitotoxicity, dysfunctional synapses, and oxidative stress. This study was conducted to investigate the beneficial role of Flavonoid (naringin) on 3 NPA induced neurotoxicity in HD experimental rat model. 3 NPA (10 mg/kg body weight (b.w.) was administered intraperitoneally (i.p.) for 21 days. Naringin was administered orally (20, 50 and 100 mg/kg b.w.) with i.p. administration of 3 NPA. One additional standard drug (NMDA antagonist) is also administered as control drug. Body weight and behavioural parameters (Actophotometer, rotarod, open field, grip strength and narrow beam activity) were assessed on the 0, 1st, 7th, and 21st day post-3-NP administration. Lipid peroxidase, nitrite concentration, endogenous antioxidant enzymes (superoxide dismutase and catalase levels), Nrf2, mitochondrial enzyme complexes (1st, 2nd, and 4th), proinflammatory compounds (TNF-a, IL-6, NF-kB), and caspase-3 activity were measured on day 22 in the striatum. 3 NPA administration significantly reduced body weight, locomotor activity, oxidative defence, mitochondrial enzyme complex activities and increased TNF-a, IL-6, caspase-3 activity, and NF-kB levels in the striatum. Treatment with naringin attenuated the impairment in behavioural, biochemical, and mitochondrial, pro-inflammatory and proapoptotic markers as compared with vehicle-treated group. All these changes were supported by histopathological observations. These findings demonstrate that naringin exerts a neuroprotective effect against oxidative stress in 3 NPA induced HD rat model. Keywords: Naringin, 3 NPA, Huntington disease, Neurodegeneration, Oxidative stress. NEUROPROTECTIVE EFFECT OF FLAVONOID IN 3 NPA INDUCED EXPERIMENTAL ANIMAL MODEL OF HD PHENOTYPE VIA REGULATING NRF2/NF-KB SIGNALING PATHWAY ICLTIPB/PH/2023/10175 Afsha Khan [email protected] Abstract: The usage of artificial intelligence in pharmaceutical technology has grown over time, and it now helps us comprehend the correlations between various formulations and process parameters while also saving time and money. A subfield of computer science called artificial intelligence deals with the use of symbolic programming to solve problems. It has significantly developed into a problemsolving science with numerous applications in business, medicine, and engineering. The article discusses the development of novel peptides from natural foods, the treatment and management of rare diseases, drug adherence and dosage, and challenges to the adoption of AI in pharma. It also discusses the tools of AI, manufacturing execution systems, automated control process systems, and AI to predict new treatments. Keywords: Drug discovery, artificial intelligence (AI) technologies, MES, ACPS, drug adherence, dosage. ARTIFICIAL INTELLIGENCE IN PHARMACY ICLTIPB/PH/2023/10176 Devansh Vijayvargiya School of Pharmacy, Kota University, Kota (Rajasthan) [email protected]
125 Souvenir Souvenir 126 Abstract: Sacred groves are tracts of virgin forest with rich diversity, which have been protected by the local people for centuries for their cultural and religious beliefs and taboos that the deities reside in them and protect the villagers from different calamities. Every sacred grove carries its own legends, lore and myths from the integral part of the sacred grove. The present study were carried out in the Kelkhoyra shiv temple. Kelkhoyra shiv temple located in ghatoli village in bakani tehsil in jhalawar district of Rajasthan, India. Distance from jhalawar about 68 km. Kelkhoyra is a very famous temple of hindu lord shiva (Vartak et al.,1981b). Kelkhoyra is a ideal centre for biodiversity conservation. It is a finest example of in-situ conservation of biodiversity and having a significant religious connotation with gurjar, meena and jogi communities. Hunting, logging and illegal human interferences are prohibited in the area. Research work was done by the survey, database, interview and questionnaire method. The main objective of present research work is to study the biodiversity of the region and methods of conservation to find out the causes and effects of biodiversity degradation. Floral species are also listed according to their characteristics like religious, medicinal, food, fodder, timber etc. Through this study we highlighting the potential of this area like religious value, floral, fauna and biodiversity conservation etc. These SGs preserve the endemic, endangered and economic important plant species and thereby play important role in biodiversity conservation. However, most of them are being destroyed due to modernization and mismanagement therefor appropriate management is required for their protection. Keywords: Virgin Forest, sacred groves, kelkhoyra, flora, fauna, conservation. SGs OF KELKHOYRA SHIV TEMPLE, JHALAWAR - IDEAL CENTRE FOR BIODIVERSITY CONSERVATION. ICLTIPB/PH/2023/10178 Prakash Yadav, Savita Gupta Department of Botany, Government College, Kota, Rajasthan. [email protected] Abstract: Pollution means, “the presence of undesirable substance in any segment of environment, primarily due to human activity discharging by-products, waste products or harmful secondary products, which are harmful to man and other organisms”. Noise pollution is an emerging environmental threat, prolonged exposure of which can cause annoyance, sleep disturbance, hypertension, psychiatric disorders, and also hormonal dysfunction. Among all the sources of noise pollution, the noise generated by road vehicle traffic significantly affects the quality of urban environments. Concerning the recent imposition of COVID-19 societal lockdown, this study attempts to investigate the impacts of COVID-19 lockdown on the changes in noise pollution levels before, during, and after lockdown phase in different residential, commercial, industrial area of Jaipur (Raj). Sound is a form of energy which is generally measured in definite unit called, Hertz (Hz)'. Although a significant reduction in the noise levels was observed during lockdown, except for commercial zone, all other monitoring stations had reported sound levels quite higher than the recommended noise limits set by the Central Pollution Control Board (CPCB) of India. In order to assess the impact of predominating Noise Level in Jaipur city, Noise Level Monitoring was conducted at 6 different locations in Jaipur City from January to March, 2018. The Noise level monitoring was conducted day time (1100 hrs to 2200 hrs) and night time (2200 hrs onwards) for half hour interval at each location with sampling frequency of one second. Results further indicated that the impact of road traffic noise on risk of high annoyance and sleep disturbance was found to be lower during lockdown as compared to that of pre-lockdown and unlock phase. While the annoyance level in residential (86.23%), industrial (87.44%), and silence (84.47%) was higher in pre-lockdown period, it reduced to 41.25, 50.28, and 43.07% in the lockdown phase. Even the risk of sleep disturbance in the residential zone was found to reduce from 37.96% during pre-lockdown to 14.72% during lockdown phase. Keywords: COVID-19; India; Noise pollution; Residential; Silence. STATISTICAL ANALYSIS OF SOUND POLLUTION PRE AND POST COVID PERIOD IN MANSAROVER AREA JAIPUR (RAJASTHAN) ICLTIPB/PH/2023/10177 Pooja Bhatnagar Career Point University, Kota (Raj.) | [email protected] Abstract: Depression as a disorder has always been a focus of attention of researchers in India. Over the last 50-60 years, large number of studies has been published from India addressing various aspects of this commonly prevalent disorder. The various aspects studied included epidemiology, demographic and psychosocial risk factor, neurobiology, symptomatology, comorbidity, assessment and diagnosis, impact of depression, treatment related issues and prevention of depression in addition to the efficacy and tolerability of various antidepressants. Here, we review data on various aspects of depression, originating from India. Keywords:DALYs- disability adjusted life years, PHQ- patient health questionnaire, 5HIAA- 5-hydroxy indoleacetic acid, CSF- cerebra spine fluid, HVA- homo vanillic acid. TO OBSERVE DEPRESSION, MENTAL ILLNESS, THERAPY & TREATMENT ICLTIPB/PH/2023/10179 * Shyam Baran Singh , Chetan Kumar Dubey, Abhishek Nagar, M.K. Gupta Career Point School of Pharmacy, Career Point School of Pharmacy, CPU, Kota (raj.) [email protected] Abstract: Using the Melt Granulation Technique, this study sought to improve the Solubility, Dissolution rate, and Bioavailability of the weakly water-soluble drug Sorafenib. Sorafenib Melt Granules were prepared by combining various meltable binders in varying proportions. All formulations were examined for solubility, practical yield, drug content, and drug release in vitro. On the basis of drug release, the optimal formulation was selected and further characterised with FTIR, XRD, and SEM analyses. Tablets were prepared with best formulation and were compared with marketed product for invitro drug release. Bioavailability studies in rats were also performed for pure drug and best formulation to know the invivo performance. Formulations prepared using various meltable binders exhibited enhanced solubility compared to pure drug. Invitro drug release studies performed displayed highest drug release of 99.08 ± 1.02% for the formulation containing Poloxamer 188 in 1:0.75 ratio (MG 3). The FTIR analysis of Formulation MG 3 revealed no significant changes, indicating that there are no interactions between the drug and excipients. The transformation of Sorafenib from crystalline to amorphous was observed by Xray diffraction and confirmed by scanning electron microscopy. Prepared tablets with best formulation showed equivalent drug release with that of the marketed product and Stability studies proved the formulation was stable for 3 months. The in vivo bioavailability studies done on rats indicate that at all time points, the plasma concentrations of the drug in animals administered the optimal formulation were greater than those of the pure drug. The Cmax of best formulation was 8.09±0.06 µg/ml and was significant (p<0.05) when compared to pure drug suspension formulation (5.65±0.09 µg/ml). The Tmax of best formulation and pure drug were 10.0±0.05 and 12±0.2 h, respectively. The AUC0-∞ for best formulation was higher 240.56±1.05 µg. h/ml than the pure drug suspension 145.18±1.72 µg. h/ml indicating better systemic drug absorption from Melt granulation formulation. Keywords: Sorafenib, Solubility, Melt Granulation, Poloxamer 188, Bioavailability, Invivo studies MELT GRANULATION – A PROMISING APPROACH FOR IMPROVING THE BIOAVAILABILITY OF POORLY SOLUBLE DRUG - SORAFENIB ICLTIPB/PH/2023/10180 T. Naga Aparna, A. Sambasiva Rao Department of Pharmaceutics, Sri Indu Institute of Pharmacy, Sheriguda (V), Ibrahimpatnam (M), R.R District, Hyderabad Telangana [email protected]
127 Souvenir Souvenir 128 Abstract: Free radicals contribute to more than one hundred disorders in humans. The synthetic antioxidants have been suspected to cause or prompt negative health effects leading to extensive research on naturally occurring antioxidants especially from plant sources. The aim of the present study was to evaluate qualitative and quantitative phytochemical constituents and in vitro antioxidant activities of leaves of Paeonia emodi. Antioxidant activity was carried out by using 1, 1-diphenyl-2-picrylhydrazyl radical (DPPH) assay. The phytochemical screening of leaves of Paeonia emodi revealed the presence of Flavonoid, Phenol, Carbohydrates and Saponins in Hydroalcoholic extract.The percentage yield of Pet. ether and Hydroalcoholic extract of the leaves of Paeonia emodi was found to be 0.756, 2.524% w/w. The total phenolic and flavonoids content of Paeonia emodi leaves of hydroalcoholic extract was found to be 0.965 and 1.214mg/100mg respectively. The results of DPPH s c a v e n g i n g a c t i v i t y f o r l e a v e e t h a n o l i c extract showed IC50 value 82.22, when compared to Ascorbic acid (standard) was 17.68. antidiabetic activitythe IC50 values were examined 35.33μg/ml for Acarbose and 279.39μg/ml for Paeonia emodi extract. It indicates the plant has the potency of scavenging free radicals and antidiabetic potential it may provide leads in the ongoing search for natural antioxidants from various medicinal plants to be used i n tr e a ti n g d i s e a s e s r e l a t e d t o fr e e r a d i c a l reactions. Keywords: Paeonia emodi, Phytochemical Screening, Antioxidant activity, Antidiabetic. PHYTOCHEMICAL SCREENING, IN VITRO ANTI-OXIDANT ACTIVITYAND IN VITRO ANTI-DIABETIC ACTIVITY OF LEAVES OF PAEONIAEMODI EXTRACT ICLTIPB/PH/2023/10182 Rakesh Kumar Niranjan Bhagwan Aadinath College of Pharmacy, Lalitpur (U.P.) [email protected] Abstract: The treatment of bacterial infections with antibiotics is a common and significant medical practise. While some antibiotics attack or dissolve bacterial cell walls, others prevent them from producing proteins. This either eliminates the bacterium or prevents it from growing and spreading. Liquid, pill, and capsule forms of oral antibiotics are all readily available. Skin creams, sprays, and ointments are examples of topical antibiotics. There are also ear drops, eye drops, and ointments for the eyes. Antibiotics may be needed by injection or intravenously for severe illnesses. For the treatment of illnesses like bronchitis, inner ear infections, and strep throat, medical experts frequently prescribe various antibiotics. These moderate to severe infections in this case have not responded to other therapies. Colds, the flu, and mono are viral infections that cannot be treated with antibiotics. These medications are categorised based on their chemical makeup and antibacterial activity. It's critical to use the proper kind of antibiotic since particular antibiotics attack particular microorganisms. To establish which antibiotics you require, a medical expert may request a lab culture test. Continu reading to discover more about the most popular antibiotic categories and the ailments they cure. We also look at some of the more typical side effects of antibiotics, such as nausea, vomiting, and diarrhoea as well as more severe ones. Keywords: antibiotics, intravenously, bacterium, nausea, vomiting, illnesses. SYNDROMES ASSOCIATED WITH ANTIBIOTICS ICLTIPB/PH/2023/10181 Lokesh Singh, Anamika Rathore, Mayank Kulshreshtha Department of Pharmacology, Rajiv Academy for Pharmacy, Mathura (U.P.), India [email protected] Abstract: Oral inflammatory disease (OID) is among the most common oral lesions, affecting people's quality of life and even leading to oral cancer. Oral ulcers are the most common OID. A mouth ulcer is characterized by the loss or erosion of part of the delicate tissue that lines the oral cavity (ie, the mucous membrane). Although the cause of most mouth ulcers in many cases is not clear, accidental damage is a common cause. The aim of the present study was to develop the mucoadhesive buccal film of Betamethasone by solvent casting method using Natural polymer Chitosan and Carbopol (CP) 940P, Propylene glycol as a plasticizer, Stevia as a natural sweetening agent and Hydrogenated castor oil as a flavouring agent. All the formulations were examined for film thickness, weight variation, drug content, percentage moisture loss, percentage moisture absorption, surface pH, folding endurance, tensile strength, in vitro and in vivo residence time and in vitro release. All prepared buccal films were transparent, smooth, consistent and flexible. The percentage moisture loss and percentage moisture absorption of the optimised formulation were found to be satisfactory. The surface pH of all formulations showed to be neutral. In vitro residence time of all patches showed above 20 minutes. The optimized formulation showed optimum tensile strength which indicates less probability of rupture. Stability studies were performed for optimised formulation and showed no appreciable change. The conclusion of the study was that the Mucoadhesive buccal films were successfully prepared by solvent casting method using different materials. e buccal films that it contains a lower drug dose, adequate for therapeutic effect as it is placed directly on the site of the inflammation when compared to conventional administration. Keywords: Mucoadhesive buccal film, Betamethasone, Solvent casting In vitro release. FORMULATION DEVELOPMENT & EVALUATION OF MUCOADHESIVE BUCCAL FILM OF BETAMETHASONE FOR ORAL ULCER TREATMENT ICLTIPB/PH/2023/10183 Shalini Vivek College Of Technical Education, Bijnor [email protected] Abstract: Drug delivery is a method or a process of administering a pharmaceutical compound, to achieve a therapeutic effect in humans or animals. For the treatment of human diseases, nasal and pulmonary routes of drug delivery are having enlarged importance. These routes provide favourable alternatives to parenteral drug delivery, particularly for peptide and protein therapeutics. For this purpose, several drug delivery systems have been mapped out and are being investigated for nasal and pulmonary delivery. These include liposomes, proliposomes, microspheres, gels, prodrugs, cyclodextrins, and others. Nanoparticles, composed of biodegradable polymers show assurance in attaining the severe requirements placed on these delivery systems, such as ability to transfer into an aerosol, stability against forces caused during aerosolization, biocompatibility, targeting of specific sites or cell populations in the lung, release of the drug in a fixed manner, and degradation during an acceptable period of time. There are a number of factors stimulating interest in the development of these new devices, concepts, and techniques. Conventional drug administration methods, while widely utilized, have many problems that may be potentially overcome by these methods. Equally important, these advances may appear attractive relative to the costs of new drug development. Keywords: Proliposomes, Cyclodextrins, Nanoparticles, Aerosolization, Biocompatibility. DRUG DELIVERY SYSTEM ICLTIPB/PH/2023/10184 Akshat Sharma, Bhanu Pratap Singh Department of Pharmacy, University of Kota | [email protected]
129 Souvenir Souvenir 130 Abstract: The aim of this study was to develop and evaluate an emul gel of celecoxib using natural oil and carbopol-940 as a gelling agent in different concentrations. The screening of various oils, co-surfactants and surfactants was performed to determine the solubility. The essential oils (eucalyptus oil and turpentine oil) were used as penetration modifiers. Studies on compatibility with polymers have been conducted and the results indicate that there should be no physical or chemical interactions between the polymers and the drug substance. For the preparation of emulgel, various emulsions were prepared with Smix (cosurfactant and surfactant) ratios (1:1, 2:1 and 3:1). The selection of gelling agent was done by incorporating the selected emulsion system ratio of 1:1 with the combinations of polymers carbopol 940, carbopol 934 and HPMC (0:1:0, 0:0.5:1, 0:0:3, 0.5:0:1, 1:0:0) gel base to make a homogenous emulgel. The emulgel was examined visually to see if it had any phase behaviour, feel, spreadability and grittiness by applying a thin layer of emulgel to a slide. Then all six formulations of emulgel were prepared with the selected gelling agent. All emulgels were evaluated for pH, physical properties (consistency, homogeneity, colour, texture), drug content, spreadability, extrudability, swelling index, viscosity, stability and centrifugation. A Franz diffusion cell and an egg membrane are used to perform in-vitro drug release. Among all prepared formulations, EG1 has better release, higher viscosity, higher drug content, and a higher swelling index than the others. The formulation EG1 shows higher drug release (91.25%) within 8 hours. Keywords: Celecoxib, penetration modifier, essential oils, gelling agent, (non-steroidal anti-inflammatory drugs) NSAIDs, emulsion. DEVELOPMENT AND EVALUATION OF EMULGEL OF CELECOXIB BY USING NATURAL OIL ICLTIPB/PH/2023/10186 Arati Rajput, Vibha Rajiv Academy for Pharmacy (RAP), Mathura (Uttar Pradesh), India [email protected] Abstract: Drug discovery is a process aims at identifying a compound therapeutically useful in curing and treating disease. This process involves the identification of candidates, synthesis, characterization, validation, optimization, screening and assays for therapeutic efficacy once a compound is selected for investigation, it will initiate the process of drug development earlier to clinical trials. The new drug must complete several test before it get to the consumer. Over all the development of new drug take sufficiently long time its complex and also very expensive. Large numbers of molecules are screened out and only a single molecule gets approved in later stage of clinical trials and finally made obtainable for patients. It takes many years for a raw drug to get approved as a medicine and requires heavy investment. The success ratio is also very low. The drug development phase involves stringent testing and optimization of the selected compounds to identify the 'most suitable drug candidate' which should be the most effective in terms of safety, toxicity and efficacy This part of the development process is called preclinical phase. The phase followed by clinical phase of development consists of 3 phases: - Phase 1: perform initial human testing in a small group of healthy volunteers, Phase 2: involves testing on a small group of patients, Phase 3: includes testing on a large group of patients to show safety and efficacy of the drug candidate in them. Since the healthy and sick people have potentially different metabolic patterns for the drugs. As we can see the need for new medicine is increasing day by day, this will also cause an increase in need of new drugs that will lead to new drug discovery and growth of sector as the time passes. Keywords: Clinical trials, validation, most suitable drug candidate, efficacy DRUG DISCOVERY AND ITS DEVELOPMENT ICLTIPB/PH/2023/10185 Rahul Suman, Bhanu Pratap Singh Department of Pharmacy, University of Kota [email protected] Abstract: Proniosomes are a prodrug approach. They are in nonhydrated inactive form when formulated and get therapeutically active on hydration as they get transformed into niosomes. The present review enlightens about proniosomes, their types, and mechanism of action, formulation methodologies, and their characterization parameters. This review article also explains the advantages of proniosomes over conventional vesicular drug delivery systems, predominantly, niosomes. Proniosomes are known to have a better stability, shelf-life, better drug penetration efficiency, and very less chances of drug leakage as compared to that in traditional vesicular delivery systems. Proniosomes are a promising approach and this study compiles various viewpoints on this novel vesicular approach of topical as well as transdermal drug delivery. Keywords: Proniosomes, Transdermal drug delivery, nanoparticles. A BRIEF ASSESSMENT OF RECENT IMPROVEMENTS IN NONIONIC SURFACTANT-BASED NANO-VESICLES (PRONIOSOMES) FOR IMPROVING TRANSDERMAL DRUG DELIVERY ICLTIPB/PH/2023/10187 1 1 1 2 Deepak kumar Gupta , Akhilesh Tiwari , Pranay soni , Megha joshi 1 Department of Pharmacy, Indira Gandhi National Tribal University, Amarkantak, India 4 Institute of Pharmacy, Vikram University, Ujjain, India [email protected] Abstract: Health issues can significantly impact the pharmaceutical industry in modern times, especially in Rajasthan, India. The state of Rajasthan is known for its rich culture, heritage, and tourism, but it is also home to a large population that suffers from various health issues such as diabetes, cardiovascular disease, and cancer. This research paper explores the impact of these health issues on the pharmaceutical industry in Rajasthan. The study investigates the increased demand for medicines, the development of new treatments, regulatory changes, supply chain disruptions, and public perception. The data for this study was collected through a combination of primary and secondary sources. The primary data was collected through interviews with pharmaceutical company executives, healthcare professionals, and patients in Rajasthan. The secondary data was collected from reports and studies conducted by various organizations such as the World Health Organization, Indian Pharmaceutical Alliance, and the Government of Rajasthan. The findings suggest that health issues significantly impact the pharmaceutical industry in Rajasthan. Increased demand for medicines has led to an increase in the production and sales of pharmaceuticals. However, regulatory changes and supply chain disruptions have led to operational and financial impacts for pharmaceutical companies operating in Rajasthan. Furthermore, public perception of the pharmaceutical industry has been affected by concerns about the safety and efficacy of vaccines. In conclusion, this research paper highlights the importance of considering health issues when analyzing the pharmaceutical industry in Rajasthan. Keywords: Health issues, pharmaceutical industry, Rajasthan, India, Demand, Development, Regulation, Supply chain, public perception. IMPACT OF HEALTH ISSUES IN THE PHARMACEUTICAL FIELD IN MODERN TIMES IN RAJASTHAN ICLTIPB/PH/2023/10188 1 2 3 Ashish Jorasia , Ashutosh Kumar , Ravindra Singh 1 School of Arts and Humanities, Career Point University, Kota, 2 School of Commerce and Management, Career Point University, Kota, 3 School of Arts and Humanities, Career Point University, Kota. [email protected]
131 Souvenir Souvenir 132 Abstract: The pharmaceutical industry is a highly regulated and capital-intensive sector that requires significant investments in research and development, manufacturing, and marketing. In this context, the financial structure of the pharmaceutical industry is essential to ensure its sustainability and growth. The financial structure of the pharmaceutical industry refers to the way pharmaceutical companies finance their operations, including the sources of capital, debt-to-equity ratios, and other financial metrics. The financial structure of the industry is crucial for companies to make strategic decisions related to investments, acquisitions, and partnerships. One of the primary sources of capital for the pharmaceutical industry is equity financing. Pharmaceutical companies can raise funds by issuing equity shares to the public or private investors. Equity financing provides long-term capital, and investors become shareholders in the company, sharing the risks and rewards of the business. The pharmaceutical industry is highly attractive to equity investors due to its potential for high growth and probability. Debt financing is another source of capital for pharmaceutical companies. Debt financing involves borrowing funds from banks, financial institutions, or issuing bonds. Debt financing provides short-term and long-term capital and enables companies to finance their operations, including research and development, manufacturing, and marketing. However, debt financing also increases the company's financial leverage, leading to increase risks and costs. Pharmaceutical companies can also raise funds through venture capital firms. Venture capital firms invest in pharmaceutical companies in exchange for equity shares. Venture capital firms typically invest in early-stage companies with a high potential for growth, providing long-term capital to fuel their growth. Venture capital firms also provide management support and strategic guidance to help companies achieve their growth objectives. Keywords: Pharmaceutical Industry, Equity Financing, Debt Financing, Venture Capital. FINANCIAL STRUCTURE OF THE PHARMACEUTICALS INDUSTRY ICLTIPB/PH/2023/10190 Ravi Ranjan School of Commerce and Management, Career Point University, Kota (Rajasthan) [email protected] Abstract: According to WHO, the prevalence of diabetes is likely to increase by 35%. Currently there are over 150 million diabetics worldwide and this is likely to increase to 300 million or more by the year 2025. International Diabetes Federation (IDF) estimates the total number of diabetic subjects to be around 40.9 million in India and this is further set to rise to 69.9 million by the year 2025. In view of the above discussion this study was undertaken to investigate Antidiabetic activity of polyherbal formulation Oroxylum indicum (Bark) in alloxan induced diabetic rats. Diabetes was induced by single intraperitoneal injection of alloxan (150 mg kg/ body weight). The various treatments were given orally for 21 days and blood glucose was estimated on 0, 7, 14 and 21 day. At the end of study estimation of serum triglycerides, total cholesterol, HDL, VLDL, LDL, was performed in serum. Oral administration of Oroxylum indicum(Bark) to diabetic rats at a dose of 250 mg/kg body weight resulted in a significant reduction in blood glucose and lipids in serum in alloxan diabetic rats. There was a significant reduction in no. of islets and β cell in alloxan treated group. Thus, our investigation clearly shows that Oroxylum indicum (Bark) has slightly less antidiabetic effects. Keywords:Oroxylum indicum (Bark), Alloxan, OGTT EVALUATION OF OROXYLUM INDICUM ON ALLOXAN INDUCED RATS FOR ANTIDIABETIC ACTIVITY ICLTIPB/PH/2023/10189 Om Sugandhi, Saurabh Chaturvedi, Rahul Ancheria, Chetan Dubey Career Point School of Pharmacy, Career Point University, Alaniya, Kota [email protected] Abstract: Tumor treatment requires a long-term regimen of chemotherapy, and both surgical tumor resection and radiation therapy are also used. The present study aimed to develop a novel method for 5-fluorouracil (5-FU)-loaded microspheres which enhance the therapeutic effects of chemotherapy, the quality of life of patients and reduce chemotherapy systemic side-effects. In this study crosslinked chitosan microspheres containing 5-Fluorouracil (5- FU) were prepared by two different methods. Variables believed to be important for microsphere properties were examined; these included: Concentration of chitosan, Type of oily phase, Types of cross-linkers and Cross-linking time. Initial 5-FU concentration, the type and concentration of chitosan, the viscosity of oil phase and glutaraldehyde concentration affected drug release from chitosan microspheres. 5-FU release from cross-linked chitosan microspheres is characterized by an initial rapid release of drug. The study was aimed at develop finest method for preparation of the porous microspheres, which can control the drug release up to 6 h and hence it can prevent the acid decomposition in stomach. Keywords: Tumor, chemotherapy, 5-fluorouracil, stomach, chitosan. FORMULATION AND COMPARISON BETWEEN TWO METHODS FOR 5-FLUOROURACIL-LOADED CHITOSAN MICROSPHERES ICLTIPB/PH/2023/10191 Dipak V. Bhusari Department of Pharmaceutics Rajarshi Shahu College of Pharmacy, Buldana, Maharashtra, India [email protected] Abstract: Working capital management that is carefully thought out & put into practice should help to increase a company's worth. This essay's goal is to investigate working capital management trends & how they affect business success. This study looks at the difficulties with working capital management & the growth during the lockdown in businesses that produce leather-based consumer goods. Working capital is needed for daily operations in the corporate world. Data were gathered for this research utilizing both primary & secondary data-gathering techniques. The sample size for this study is based on responses from the top 10 leather firms, of which we have data from nine. So, for the primary survey questionaries were distributed to the 100 respondents in the Dharavi region in Mumbai. The researcher advises the businesses' management to use a working capital management strategy which lowers idle cash, the average collection time, inventories in days, & the average payment time. Keywords: GST, capital, Dharavi, inventories. A STUDY ON CHALLENGES IN IMPLEMENTATION OF GST WITH RESPECT TO RESTAURANT INDUSTRY ICLTIPB/PH/2023/10192 Jyoti Peswani, Dr. Deepak Verma Chatrapati Shivaji Maharaj University, Panvel, Navi Mumbai [email protected]
133 Souvenir Souvenir 134 Abstract: Structural, electronic and optical properties of sio2 material has been performed using the full potential linearized augmented plane wave (FP-LAPW) method with generalized gradient approximatic implement In WIEN2K structure of SiO2. The direct and indirect band gaps of sio2 /ac nanocomposites were determined by UV-Vis analysis for SiO2 /ac nanocomposites before annealing positive indirect band gap was changed from 3.45 to 6.13ev and after annealing at T=300 c , was changed from 3.63 to 5.66 ev . the direct band gap, before annealing was changed from 5.04 to 6.33 ev and , after annealing at T=300 c was changed from 5.88 to 6.21 ev . Silicon dioxide sio2 is the low – index low absorption material used in combination with high – index oxide layer coatings that operate in the UV (~200nm) to IK (- 3um) regions. Keywords: Optical Properties, SiO2, electronic, plane wave, nanocomposites. STRUCTRAL ELECTRONIC AND OPTICAL PROPERTIES OF SIO2 MATERIALS ICLTIPB/PH/2023/10194 Sakshi Shukla Career Point University, Kota, Rajasthan [email protected] Abstract: The aim of this study was to evaluate the in vitro antioxidant activity and antidiabetic activity of Hydro-alcoholic extract of selected common agricultural weed plants. The in vitro antioxidant activity of Hydro-alcoholic extract of 8 selected common agricultural weed plants was analyzed by using DPPH Assay and then the plant extract showed highest antioxidant activity were further analyzed for their antidiabetic activity in STZ induced diabetic SD rats. Among all the plant extracts, potential of the radical scavenging activity of the tested plants extracts were in the followingorder:Cyperusrotundus>Cynodondacty lone>Diger a muricata>Celosia argentea>Corchorus olitorius> Fumeria indica> Achyranthes aspera> Chenopodium album. Out of all plant extracts Cyperus rotundus and Cynodon dactylone exhibited the highest antioxidant activity against DPPH radical among all the tested plant extracts. The extract of plant Cyperus rotundus showed significant antidiabetic activity in STZ induced diabetic SD Rats. The Hydro-alcoholic extract of Cyperus rotundus and Cynodon dactylone showed good antidiabetic activity against the diabetes induced by STZ in SD rats due to its good antioxidant activity. Keywords: Antioxidant, DPPH Assay, Radical scavenging activity, Antidiabetic activity, weed plants. IN VITRO ANTIOXIDANT AND ANTIDIABETIC ACTIVITY OF HYDRO-ALCOHOLIC EXTRACT OF SELECTED COMMON AGRICULTURAL WEED PLANTS ICLTIPB/PH/2023/10195 1 1 2 Anil Kumar Meena , S. K. Rath & Monish Banergee 1 Toxicology and Experimental Medicine Division, CSIR-CDRI, Lucknow-226031 2Molecular Human Genetics Laboratory, Department of Zoology, University of Lucknow, Lucknow26025 [email protected] Abstract: Working capital management that is carefully thought out & put into practice should help to increase a company's worth. This essay's goal is to investigate working capital management trends & how they affect business success. This study looks at the difficulties with working capital management & the growth during the lockdown in businesses that produce leather-based consumer goods. Working capital is needed for daily operations in the corporate world. Data were gathered for this research utilizing both primary & secondary data-gathering techniques. The sample size for this study is based on responses from the top 10 leather firms, of which we have data from nine. So for the primary survey questionaries' were distributed to the 100 respondents in the Dharavi region in Mumbai. The researcher advises the businesses' management to use a working capital management strategy which lowers idle cash, the average collection time, inventories in days, & the average payment time. Keywords:Capital, business, leather, data, questionaries. MANAGEMENT OF SHORT-TERM CAPITAL IN LEATHER INDUSTRIES ICLTIPB/PH/2023/10193 Fayeza Hakimuddin Sonkachwala, Deepak Verma Rajiv Academy for Pharmacy (RAP), Mathura (Uttar Pradesh), India [email protected] Abstract: Consumer behaviour and the way they make decisions have developed over the past few years and are now a key subject in marketing. This essay details how tourists behave in terms of concepts, influences, and possibilities. Identifying trends to address these needs, such as whether to purchase goods and services and, if so, which brands and where, as well as interpreting advice and developing and carrying out plans to do so. The psychological process that customers go through to determine their needs is included in consumer behaviour. Researchers use a narrative review to investigate the Consumer Behaviour literature published in three significant tourist publications between 2000 and 2012. The key ideas, outside influences, and appropriate study contexts in current tourism CB research are examined in this review paper. Although consumer behaviour (CB) is one of the tourist industry's most explored topics, there aren't many thorough reviews of the body of knowledge in this discipline. Nine essential themes, including values, motivation, expectations, attitudes, perceptions, satisfaction, trust and loyalty, and technology, were examined for their development and the potential for future research. Researchers have looked at three significant Groups and Joint Decision-Making, emotions, and unethical consumer behaviour. Lastly, group and collaborative decision-making, emotions, and consumer misbehaviour have been recognised and explored as research contexts that constitute key prospects for future scholarship. Keywords: Consumer, Behaviour, Misbehaviour, Motivation, Values, Trust & loyalty, Emotions, Travel & Technology, Attitude, Perception, Satisfaction, Consumption, Tourism, Travel, Marketing. A REVIEW PAPER ON “CONSUMER BEHAVIOUR IN TOURISM: CONCEPTS, INFLUENCES AND OPPORTUNITIES ICLTIPB/PH/2023/10196 Ashutosh Kumar, Priya Vijay School of Commerce and Management, Career Point University, Kota [email protected]
135 Souvenir Souvenir 136 Abstract: Picrorhiza kurroa is an important medicinal herb in traditional ayurvedic and Tibetan medicine. It has been used for centuries to treat a variety of diseases, including liver disease. Present studies have suggested that Picrorhiza kurroa have potential as a therapeutic agent for treating Isoniazid−rifampicin. Isoniazid-rifampicin is anti-tubercular that is commonly used in industrial and laboratory settings. Exposure to Isoniazid-rifampicin can cause damage to the liver, resulting in severe liver diseases. The protective effect of Picrorhiza kurroa root and leaves on INH and RFP-induced liver injury involve regulating multiple pathways. The results of the Picrorhiza kurroa root and leaves show the prevention and treatment of the Isoniazid−rifampicin -induced liver injury. In addition, antioxidant also plays a critical role in the treatment of Isoniazid−rifampicin -induced liver injury. However, Picrorhiza kurroa root and leaves have both antioxidant and pro-oxidative effects. High-dose of Picrorhiza kurroa root and leaves (200 mg/kg) may act as a pro-oxidant and cause oxidative stress as compared to lower dose with promising action. The protective effect of Picrorhiza kurroa root and leaves on Isoniazid−rifampicin - induced livery injury were presented in this work. Further research should be carried out to discover novel solutions for preventing and treating Isoniazid−rifampicin-induced liver injury and the detailed molecular mechanisms involved in Picrorhiza kurroa root and leaves protective effect. Keywords: Picrorhiza Kurroa, Hepatoprotective, Isoniazid, Liver, Rifampicin. ISONIAZID AND RIFAMPICIN INDUCED HEPATOPROTECTIVE ACTIVITY OF ROOT AND LEAVES EXTRACT OF PICRORHIZA KURROA ICLTIPB/PH/2023/10198 Harshita Jain, Namita Arora, Pankaj Arora, Nitin Nama Faculty of Pharmaceutical Sciences, Lords University, Alwar Rajasthan [email protected] Abstract: Consumer behaviour and the way they make decisions have developed over the past few years and are now a key subject in marketing. This essay details how tourists behave in terms of concepts, influences, and possibilities. Identifying trends to address these needs, such as whether to purchase goods and services and, if so, which brands and where, as well as interpreting advice and developing and carrying out plans to do so. The psychological process that customers go through to determine their needs is included in consumer behaviour. Researchers use a narrative review to investigate the Consumer Behaviour literature published in three significant tourist publications between 2000 and 2012. The key ideas, outside influences, and appropriate study contexts in current Keywords: Consumer, Behaviour, Misbehaviour, Motivation, Values, Trust & loyalty, Emotions, Travel & Technology, Attitude, Perception, Satisfaction, Consumption, Tourism, Travel, Marketing. ENRICHMENT OF SAPONIN CONTENT IN THE WASHES OF ROOTS OF CHLOROPHYTUM BORIVILIANUM ICLTIPB/PH/2023/10197 Abhishek Nagar, Uttam Singh Baghel, Mahesh Kumar Gupta Career Point School of Pharmacy, Career Point University, Kota [email protected] Abstract: Nanoemulsions are a type of colloidal dispersions in which nano-sized droplets of one liquid are dispersed in another liquid. Bauhinia racemosa, commonly known as the mountain ebony, is a tropical tree which is widely used in traditional Indian medicine in the form of its leaves and barks. In this study, a novel nanoemulsion of Bauhinia racemosa was developed to enhance the efficacy of the active compounds present in the plant. The Box-Behnken design was used to optimize the formulation variables of the nanoemulsion. The raw material was extracted using with ethanol, and then subjected to a nanoemulsification process. The resulting nanoemulsions were characterized for their physical properties such as particle size, droplet size distribution, zeta potential, and viscosity. The formulation F2 was found to be stable with an average droplet size of 148.96nm and a zeta potential of -38.74mV. Furthermore, in vitro release studies of the nanoemulsion revealed a sustained release pattern with an increased bioavailability of the active compounds. The results of this study demonstrate that the Bauhinia racemosa nanoemulsion could be a promising delivery system for the traditional medicine. Keywords: Bauhinia racemosa, Nanoemulsions, Formulation, Evaluation. FORMULATION AND CHARACTERIZATION OF BAUHINIA RACEMOSA EXTRACT LOADED NANOEMULSION BY BOX BEHNKEN DESIGN ICLTIPB/PH/2023/10199 Nitin Nama, Pankaj Arora, Namita Arora, Harshita Jain Faculty of Pharmaceutical Sciences, Lords University, Alwar Rajasthan [email protected] Abstract: The present study was undertaken to investigate the effects of gingerol in mice. Zingiber officinale rhizomes were extracted with ethanol (95%) by simple maceration process. This extract was studied phytochemically and gingerol is isolated by using TLC and HPLC technique. The ethanolic extract of Zingiber officinale Roscoe was evaluated for antianxiety activity using elevated plus maze apparatus. Three groups named control, standard and test groups were used. Dosing was performed using intra peritoneal route. The dose of Diazepam was 2mg/kg and dose of ethanolic extract was 150 mg/Kg. The dose of 150 mg/kg significantly depicted a marked reduction in the anxiety activity of mice. The conventional models are highly sensitive to the influence of both anxiolytic and anxiogenic drugs acting at the GABA benzodiazepine complex. This animal model is considered one of the most widely validated tests for assaying sedative and anxiolytic substances such as the benzodiazepines. Keywords:Diazepam, Anxiety, Extract, GABA, TLC EVALUATION OF TOXICOLOGICAL & ANTI-ANXIETY EFFECT OF GINGEROL ICLTIPB/PH/2023/10200 Chetan Kumar Dubey, M. K. Gupta, Abhishek Nagar Career Point School of Pharmacy, Careeer Point University Kota, Rajasthan. [email protected]
137 Souvenir Souvenir 138 Abstract: We aimed to highlight the state of the art in terms of pediatric population adherence to insulin pump. This study intends to underline the significance of identifying and minimizing, to the greatest extent. Insulin pumps are external, portable and user-friendly devices that deliver insulin continuously from a refillable storage reservoir by means of a plastic cannula placed under the skin. It is intended to mimic physiological insulin delivery and can be pre-programmed to deliver an adjustable basal rate of insulin throughout the day and bolus doses (either meal time or correction boluses) to take care of the meal related glucose peaks. Insulin pump have been mainly used in patient with Type-1 diabetes, where it has been shown to improve glycaemic control and quality of life and reduce frequencies of hypoglycaemia. In recent times it has been used in pregnant women and those contemplating pregnancy and also in Type-2 Diabetes with less robust clinical benefit, although hypoglycaemic episodes of a severe nature are reduced significantly. Unlike the west, where the majority of pump users have Type-1 diabetes, in India,80% of users have type-2 diabetes and the authors personal experiences are no different. There are a number of recent technological innovations including the use of closed loop system and dual hormone delivery system, which will possibly transform the management of diabetes (particularly Type-1) in the near future. Keywords: Type-1 Diabetes, Type-2 Diabetes, Insulin pump, Hypoglycaemia, closed loop system and dual hormone delivery system. A CLINICAL OVERVIEW OF INSULIN PUMP THERAPY FOR MANAGEMENT OF DIABETES ICLTIPB/PH/2023/10202 Yogi Riya, Meghwanshi Madhuri Kota College of Pharmacy, Kota, Rajasthan [email protected] Abstract: High alitude herbs were used as herbal perfume and used incense in the folk of Himalayan region. From aerial part of the plants the alcohols and higher ester of fatty acids were isolated and identified. It is used in the manufacture of metallic stearates, pharmaceuticals, soaps, cosmetics, and food packaging. It is also used as a softener, fragrance. Pleurospermum densiflorum is an annual herb growing at an altitude of 17,500 ft along the snowlines of the Kumaon Himalayan mountains in U.P. India. It is traditionally used as one of the best herbal perfumes in the region and is known for its long-lasting pleasant smell. A literature search revealed that except for a preliminary chemical screening report. This plant has neither been investigated chemically nor even recorded as a traditional source of perfume. As part of a search for useful high altitude Himalayan herbs this plant was collected and chemically investigated. The new ester 1 was isolated and identified, along with psoralen, bergapten and /I-sitosterol. The plant has been found to be rich in coumarins and bergapten was a major constituent (0.15%). Keywords:Pleurospermum densiflorum, esters, fatty acids. A REVIEW ON ESTERS AND FATTY ACIDS FROM PLEUROSPERMUM DENSIFLORUM ICLTIPB/PH/2023/10201 Saurabh Chaturvedi, Harshita Jain, Nitin Nama Career Point School of Pharmacy, Career Point University, Kota – 325003 (RAJASTHAN) INDIA [email protected] Abstract: Microparticles are common constituents of multiparticulate drug delivery systems offering numerous advantages based on their structural and functional abilities. Controlled release systems enhace the drug's efficacy by improving its release kinetics. Resveratrol is a potent antioxidant, antiinflammator y, anti-cancer agent. Microparticles demonstrate high stabilty,good mucoadhesive property, and low cytotoxic effects. Micrparticulate drug delivery system improves the bioavailibilityof medicinal preparation. Hence, the bioavailibility of resveratrol (drug) can be improved by using microparticles as a carrier. Keywords: Microparticles, Controlled release, Antiinflammatory, Resveratrol, Bioavailibilty FORMULATION AND EVALUATION OF RESVERATROL LOADED MICROPARTICLES OR CONTROLLED DRUG DELIVERY ICLTIPB/PH/2023/10203 Shabenoor Siddiqui [email protected] Abstract: There are several factors contributing to the rise of drug abuse among children in India. One of the main factors is easy access to drugs, including prescription drugs and illicit substances. Young people can obtain drugs through peer pressure, social media, and drug dealers. Another contributing factor is a lack of awareness and education about the dangers of drug abuse. Many children and their families do not fully understand the consequences of drug use, and they may not know where to turn for help. The consequences of drug abuse among children can be severe, including addiction, overdose, and even death. Drug abuse can also lead to academic and behavioral problems, including poor performance in school and criminal behavior. To address this growing challenge, it is important to increase awareness and education about the dangers of drug abuse among children and their families. Parents and educators can work together to provide information about the risks of drug use and how to prevent it. It is also important to provide treatment and support for children who are struggling with drug abuse, including access to counseling, therapy, and rehabilitation programs. The current paper discusses the growing danger of drug misuse among children, impeding their physical, psychological, and social development in a process in which they typically learn learning, emotional, social, and life skills, with the goal of presenting the conditions of drug use among children. The purpose of this paper is to focus on the genetic correlations, psychosocial and socioeconomic influences associated with alcohol. And drug addiction in children. The report also recommends any steps to control opioid addiction in children. More research on the drug epidemic is needed in India to examine the current situation and find solutions. Keywords: Children, Drug, Drug Abuse, rehabilitation program, Awareness. CHILDREN'S DRUG ABUSE: AN INCREASING PROBLEM IN INDIA ICLTIPB/PH/2023/10204 Mithlesh Malviya School of Legal Studies and Governance, Career Point University, Kota [email protected]
139 Souvenir Souvenir 140 Abstract: The study is focused on the assessment of the external marketing environment that could affect the businesses. The study is specific to the Indian Ayurvedic cosmetic industry. The forecasting of the upcoming opportunities and threats have been assessed with the medium of the study. One of the most effective methods for the environmental analysis is the PESTLE framework has been chosen with the relevance as well as advantages and disadvantages of adopting the particular tool for the assessment. Further, this method has been used to assess the opportunities and threats to the Indian Ayurvedic cosmetic industry which enables the industry to assess the effects and impacts of planned strategies that could be utilized to influence the customer by influencing their buying behaviour from switching to the chemically formed cosmetic to the Ayurvedic cosmetics. Keywords:Ayurvedic, Pestle, cosmetic, customer. THE ETHICAL IMPLICATION OF THE AYURVEDIC COSMETIC PRODUCTS – A PESTLE ANALYSIS STUDY OF THE INDIAN AYURVEDIC COSMETIC SECTOR WITH A SPECIAL FOCUS ON INDIAN YOUTH ICLTIPB/PH/2023/10206 Ankita Nawal, Prof. Dr. Gurudutt Kakkar Career point University, Kota, Rajasthan, India. [email protected] Abstract: Hindu women in India have long endured discrimination in their families over their property rights. Women's property was split into two categories before independence: stridhan and woman's estate. If she was a married lady, there were some limitations on her power of disposal. The Hindu Succession Act of 1956 repealed the outdated stridhan and woman's estate laws. Daughters in a Hindu joint family now have the same rights as sons according to a 2005 change to the Hindu Succession Act, 1956. However, there were issues with how this article was being interpreted, which the Supreme Court rectified in a recent ruling from 2020. This essay tries to examine the property rights of women before to independence and any gaps in those rights. The report also looks at current rules that provide women an equal stake in property. In the Hindu Succession Act, statutes have been construed by the Court to offer Indian women an equal stake in the property as that of men, and this paper covers judicial advancements in this area. Keywords: Women's property rights, Hindu succession Act 1956, Gender justice. HINDU WOMEN'S RIGHTS TO PROPERTY : AN INDIAN APPROACH AFTER INDEPENDENCE ICLTIPB/PH/2023/10205 Jay Prakash Srivastava Faculty of juridical science, Rama University, Kanpur, Uttar Pradesh. [email protected] Abstract: HIV infection is responsible for many neurological problems, mainly AIDS dementia complex (ADC) which affects motor dysfunction that is responsible for NeuroAIDS. Antiretroviral (ARV) medications are in high demand for the treatment of NeuroAIDS. The primary issue with several (ARVs) is, they have low oral bioavailability which is mostly caused by their significant first-pass metabolism and poor water solubility. This study's objective is to create an ARVloaded nanoemulsion for improved NeuroAIDS care. For optimization of nanoemulsion, design expert software was used in which twenty runs were generated with three independent variables Oil (%), Smix (%), and sonication time (second), and four dependent variables with droplet size (nm), PDI, zeta potential (mV), and transmittance (%). Dependent variables had different constraints such as droplet size, PDI was minimum and zeta potential, and transmittance was maximum. For the selection of Smix ratio, pseudoternary phase diagram data was studied in which different ratios of Smix were used 1:0, 1:1, 2:1, 3:1, 4:1, 5:1and 1:2 containing tween 40 and polyethylene glycol 400 as surfactant and cosurfactant respectively and oil in ratio 9:1, 8:2, 7:3, 6:4, and 5:5 and concluded for 4:1 as Smix ratio. The droplets of the optimized nanoemulsion were spherical and had a globule-like shape with no aggregation, as shown by surface morphology as determined by TEM. The optimized nanoemulsion's particle size, zeta potential, conductivity, and percent transmittance were investigated. The result of the observed response for the formulation was found to the predicted response. Keywords: HIV, Neuro AIDS, PDI, Zeta potential, Nano emulsion. NANOEMULSION FOR THE MANAGEMENT OF NEUROAIDS BY ARV THERAPY: DEVELOPMENT AND EVALUATION ICLTIPB/PH/2023/10207 Kunal Verma, Shobhit Kumar Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology (MIET), Meerut, Uttar Pradesh, India. [email protected] Abstract: To keep the drug in the gastric medium, superporous hydrogels (SPHs) were developed. While releasing the pharmaceutical active ingredient, these systems swell very quickly within the stomach and maintain their integrity for an extended period of time even in the acidic environment of the stomach. The current study focuses on the concept of developing superporous hydrogel tablets of Labetalol Hcl and comparing them to commercially available delayed release dosage forms. SPH was evaluated using apparent density, mechanical strength, porosity, swelling studies, scanning microscopy (SEM), and FT-IR. The stability, kinetic drug release & in-vitro drug release profile, drug content, and drug content of all prepared formulations were evaluated, and the conclusions were that the proposed gastroretentive drug delivery system based on SPHs is promising for stomach specific delivery of Labetalol hydrochloride. The goal of this study was to create a gastroretentive dosage form based on SPH using Labetalol HCl, an antihypertensive, as a model drug for swelling and prolonged drug release in acidic pH. SPHs contain three different polymers: sodium alginate, pectin, chitosan, and acrylic acid, which were crosslinked with different concentrations using formaldehyde as a cross linking agent to achieve the desired sustained release profile over a period of 8-12 hours. Keywords: Superporous hydrogels, (SPHs), Labetalol Hcl, GRDDS, prolonged drug release. FORMULATION AND CHARACTERIZATION OF GASTRORETENTIVE SUPERPOROUS HYDROGEL TABLETS OF LABETALOL HYDROCHLORIDE ICLTIPB/PH/2023/10208 Ankita Malviya, Ankita Yadav, Alok Dwivedi, Pratibha Kasaudhan Buddha Institute of Pharmacy, GIDA, Gorakhpur Affiliated to Dr. APJ Abdul Kalam Technical University, Lucknow, UP, India [email protected]
141 Souvenir Souvenir 142 Abstract: Angiosperm The term "murder" refers to the act of killing someone. For millennia, the miracle tree, also known as moringa oleifera, has been used in traditional medicine. Malnutrition, diabetes, blindness, anaemia, hypertension, stress, depression, skin, arthritis, joint problems, and kidney stones are all treated with different parts of M. oleifera with no reported side effects. This plant has also been shown to help with breastfeeding management in nursing mothers, as well as the preservation of the cardiovascular system, blood glucose levels, and anti-oxidant, anti-inflammatory, and anti-cancer properties. By causing flocculation, the seed and leaf powder can filter water. The significant nutritional and preventive properties of M. oleifera seed oil have led to its use in the cosmetic and pharmaceutical industries. Because it contains a range of vital phytochemicals in its leaves, pods, and other parts of the plant, moringa is a nutritious food. In fact, moringa is claimed to have 25 times more iron than spinach and 25 times more vitamin C than oranges, 10 times more vitamin A than carrots, 17 times more calcium than milk, 9 times more protein than yoghurt, and 7 times more vitamin C than oranges. Because moringa leaves contain a variety of antioxidant components, including ascorbic acid, flavonoids, phenolics, and carotenoids, they extend the shelf life of foods that contain fat. They are also said to be a healthy source of protein, vitamin C, calcium, and potassium. Keywords: Moringa oleifera, Drumstick or Sehjan, Angiospermic Plant, Anti-Oxidant, Anti-Inflammatory, And Anti-Cancer Properties. PHARMACOLOGICAL APPLICATIONS OF MORINGA OLEIFERA (MEDICINAL PLANT) ICLTIPB/PH/2023/10210 Ankur Yadav, Akanksha Dubey, Anamika Chauhan Buddha Institute of Pharmacy, GIDA, Gorakhpur Affiliated to Dr. APJ Abdul Kalam Technical University, Lucknow, UP, India | [email protected] Abstract: The primary goal is to develop and test an anti-fungal nail lacquer that contains miconazole nitrate and is intended to treat onychomycosis, a skin condition caused by pathogens such as candida, dermatophytes, and non-dermatophytes. Nail lacquer can also help to improve therapeutic effectiveness and patient compliance. It is simple to create by combining non-volatile ingredients and achieving the desired gloss, flow, and smoothness. Humans use nail lacquer to protect their fingernails and toes. It is critical to protect the nail and nail plate in order to enhance beauty, gloss, and colour. Nail lacquer is commonly used for medications with low oral bioavailability to increase topical absorption of the drug over the nail. To construct the medicine and provide the best possible release, this preparation incorporates a number of ingredients, including 2 hydroxy propyl beta cyclodextrin, ethyl cellulose, nitrocellulose, and propylene glycol. Drugs are able to pass through the nail plate. When something becomes tough enough, it is difficult to penetrate; only a small amount of topical medication can pass through. As a result, the therapeutic concentration fails to work. Because of the reduced luminescence, the nail plate may appear odd. It involves the nail bed, reduces blood flow, or has chemical or physical nail bed characteristics. As a result, a variety of diseases emerge. To effectively treat nail disease, the administered active medicine must penetrate the thick, keratinized nail plate and reach deeper layers, the nail bed and the nail matrix. Human skin research has revealed its structure, functions, and permeability to certain substances, but little is known about the nail, its keratin content, or how skin develops from the nail. It is critical to have a better understanding of the physicochemical factors that affect medication absorption through the nail plate in order to treat not only external nail illnesses but also potential systemic circulation and nearby target locations. Keywords: Fungal Infection, Nail Lacquer, Onychomycosis, candida, dermatophytes. IN-VITRO EVALUATION OF AN ANTI-FUNGAL NAIL LACQUER CONTAINING MICONAZOLE NITRATE ICLTIPB/PH/2023/10209 Navneet Kumar Verma, Ravi Kumar Jaiswal, Sarita Yadav, Sudhanshu Yadav Buddha Institute of Pharmacy, GIDA, Gorakhpur Affiliated to Dr. APJ Abdul Kalam Technical University, Lucknow, UP, India [email protected] Abstract: The SSRIs differ chemical l y from conventional antidepressants like tricyclic, tetracyclic, and monoamine oxidase inhibitors, but they share the same mechanism of action in that they selectively and potently inhibit serotonin neuronal reuptake while having no or very little impact on norepinephrine, acetylcholine, and histamine neuronal reuptake. Fluoxetine, fluroxamine, sertraline, indalpine, paroxetine, alproclate, femorxetine, and choroxamine are examples of SSRI medications. In the absence of a simple mechanistic theory to account for antidepressant action, it is useful to look for pharmacological effects that the various drugs have in common, concentrating more on the slow adaptive changes that follow a similar time course to the therapeutic effect. The current research involves the synthesis of fluoxetine derivatives via reaction. The aforementioned mannequins were used to create the aforementioned mannequins. Mannich bases are reduced with sodium borohydride in the second step, and then etherified with p- chlorobenzotrifluride in the final step. IR, 1 H NMR, and mass spectral data were used to confirm the structure of the final compounds. Antidepressant activity of fluoxetine analogues was tested biologically. Because none of the five moieties showed a significant reduction in immobility time when compared to the standard drug. This suggests that the fluoxetine and sertraline analogues need to be modified further to achieve the desired activity. Keywords: Fluoxetine, Fluoxetine analogues, sertraline analogues, antidepressants. PHARMACOLOGICAL ACTIVITY OF FLUOXETINE AND FLUOXETINE DERIVATIVES ICLTIPB/PH/2023/10211 Shiwani Jaiswal, Dr. Asheesh Kumar Singh, Sanjana Kushwaha Buddha Institute of Pharmacy, GIDA, Gorakhpur Affiliated to Dr. APJ Abdul Kalam Technical University, Lucknow, UP, India [email protected] Abstract: The goal of this study is to assess the quality of flaxseed from various geographic sources. The review is supported by previous research demonstrating the importance of climatic factors in plant development and quality. Geographical studies of plant molecular diversity can provide significant information about plant growth and improve plant germplasm, medical benefits, and uses, but such studies are lacking for cultivated flax (Linum usitatissimum L.). Flax is one of the world's top five oil crops and the third-largest naturally harvested source of fibre. Flax is frequently used as a model plant for the best plants due to its small size and characteristics that promote self-fertilization. The climate and soil types had a significant impact on flaxseed yields, but the following generation. Cultivated flax has a wider range of generative plant parts, whereas pale flax fluctuates have more vegetative plant parts. When considering the range of variation, hereditarily based variety, heritability, and connectivity of a few traits, the effects of domestication are taken into account in particular. Higher developing season temperatures in various areas may have an impact on agricultural productivity, farm revenue, and food security. Planting was delayed, causing the natural temperature to rise during the harvest concept development, resulting in lower seed quality. The findings revealed that the planting climate has an effect on the characteristics of development, yield, and its segment, as well as oil yield. These results are significant for comprehending the domestication of flax and are also useful for classifying intraspecific cultivars of flax, establishing a core subset of the flax assortment, and looking into new sources of characteristics for flax enhancement. Keywords: Linum usitatissimum; growth performance; cultivators; seed and oil yields; genetic diversity. PHARMACOLOGICAL IMPORTANCE OF FLAX SEED (LINUM USITATISSIMMUM L.) ICLTIPB/PH/2023/10212 Vikas Yadav, Nalini Paswan, Sejal Srivastava Buddha Institute of Pharmacy, GIDA, Gorakhpur Affiliated to Dr. APJ Abdul Kalam Technical University, Lucknow, UP, India [email protected]
143 Souvenir Souvenir 144 Abstract: Solubility and bioavailability is the deciding factors for the absorption of the drugs. Drug absorption, pharmacokinetic profile of orally administered drug substances is highly dependent on the solubility of that compound in aqueous medium. Due to this major reason, solubility enhancement is one of the important parameter which should be considered in formulation development of orally administered drug with poor aqueous solubility. Insolubility, instability and low permeability are inherent problems of several herbal medicines. Aim of the present work is to improve aqueous solubility of curcumin, which belongs to Biopharmaceutical Classification System Class IVth, poor solubility and poor bioavailability. The stoichiometric ratios for complexation of curcumin with various excipients were determined by solubility studies. Physical method, kneading, solvent evaporation, microwave irradiation and freeze drying, were employed to determine curcumin complexation. The solubility of the drug in its different systems was explored. The result of physical characterization of the different systems shows no interaction between them. The curcumin and poloxamer shows highest drug solubility than other excipients with freeze drying method. The obtained results showed the preparation of complex with poloxamer by freeze drying method is a promising method to enhance aqueous solubility of curcumin. Keywords: Solubility, Curcumin, Poloxamer, Freeze Drying method. ENHANCEMENT OF NATURAL DRUG AQUEOUS SOLUBILITY BY USING VARIOUS METHOD ICLTIPB/PH/2023/10214 1 2 Neelam Yadav , Harinath Dwivedi 1 Era College of Pharmacy, Era University, Sarfarazganj, Lucknow, U.P. 2 School of Pharmacy, Babu Banarasi Das University, Faizabad Road, Lucknow, U.P. [email protected] Abstract: T h e p r e s e n t s t u d y w a s c a rri e d o u t t o e v a l u a t e thepharmacological screening of Chrozophora tinctoria leaves extract as antidiabetic effect in rat.The method is used to evaluate pharmacological potential of aqueous leaves extract as antidiabetic effect in rat. Inthis model, streptozotocin (60mg/kg b.w.) induced rats for one day through intraperitoneal administration, the effect of Chrozophoratinctoriaat different dose level that is higher dose (100mg/kg b.w. p.o.) and lower dose (50mg/kg b.w. p.o.). From the study obser ved that Chrozophoratinctoria significantly protect the destruction of β-cells of pancreas from streptozotocin induced diabetes in rats. Streptozotocin induced ruputered and destruction of islet of langerhens and acini, destruction of intralobular duct and interlobular duct, and necrosis in parts of pancreas was found to be reduced in the groups receiving Chrozophoratinctoria along with streptozotocin. Chrozphoratinctoria also normalized the streptozotocin induced diabetes decrease the blood glucose serum insulin, proteinand uric acidlevels. This is also evidenced by the histopathological studies. The antidiabetic activity of Chrozophora tinctoria was determined by having comparsion between diseased group and treatment group with reference to standard group on the basis of improvement in elevated levels of biomarkers such as blood glucose (97.8±5.7**), serum insulin(1.48±0.36**), protein(6.4±0.36**), uric acid(2.04±0.27**), triglyceride(135.2±3.20**), total cholesterol(02.5±2.6**), SGOT(88.81±6.90**), SGPT(67.8±10.28**), HDL(51.76±7.92**) and LDL(80.68±10.62**) decrease the level of TBARS(258.93±7.85**) a n d i n c r e a s e t h e l e v e l o f S O D ( 7 3 . 8 2 ± 1 0 . 6 0 **) , Catalase(16.47±0.42**) and GSH (0.47±0.21ns). At the last it was obser ved that high dose(100mg/kg) of Chrozophora tinctoriawas more significantly effective as compared to the low dose (50mg/kg) on the basis of evaluation of overall biological parameter and histopathological activities. Keywords: Diabetes, Streptozotocin, Chrozophoratinctoria, antioxidant, Blood glucose level, Serum insulin, Uric acid. PHARMACOLOGICAL SCREENING OF CHROZOPHORA TINCTORIA LEAVES EXTRACT AS ANTIDIABETIC EFFECT IN RAT ICLTIPB/PH/2023/10213 Neha Srivastava, Harikesh Maurya Buddha Institute of Pharmacy, GIDA, Gorakhpur Affiliated to Dr. APJ Abdul Kalam Technical University, Lucknow, UP, India [email protected] Abstract: This study aimed to investigate the impact of performance management systems on the motivation and job satisfaction of pharmacy staff in Rajasthan. The research methodology involved a mixed-methods approach, consisting of a survey and interviews. The survey was distributed to 200 pharmacy staff members, and 30 individuals participated in the interviews. The findings indicated that the use of performance management systems positively impacted the motivation and job satisfaction of pharmacy staff. The results also indicated that communication and feedback were essential factors in enhancing the effectiveness of performance management systems. Additionally, the study found that the use of performance management systems varied across different pharmacy settings, with chain pharmacies being more likely to utilize them than independent pharmacies. Overall, the findings suggest that the use of performance management systems can improve pharmacy staff motivation and job satisfaction in Rajasthan. Keywords: Performance management systems, pharmacy staff, motivation, job satisfaction, Rajasthan, mixedmethods, communication, feedback. A COMPREHENSIVE STUDY ON THE IMPACT OF PERFORMANCE MANAGEMENT SYSTEMS ON PHARMACY STAFF MOTIVATION AND JOB SATISFACTION IN RAJASTHAN ICLTIPB/PH/2023/10215 Kavita Jain, Sandeep Kumar School of Commerce & Management, Career Point University, Kota, Rajasthan, India. [email protected] Abstract: This comprehensive review aims to evaluate the effectiveness of pharmacists' medication therapy management (MTM) in improving patient outcomes and reducing healthcare expenditures. A systematic literature search was conducted in major databases, including PubMed, Scopus, and Cochrane Library, using relevant keywords. The search resulted in 25 eligible studies, which were critically appraised for their quality and relevance. The selected studies were diverse in terms of study design, population, intervention, and outcome measures. Most of the studies were randomized controlled trials, while some were cohort studies or quasi-experimental designs. The population varied from children to elderly adults, with a wide range of chronic conditions and medications. The interventions were delivered by pharmacists either face-toface, telephonically, or using electronic platforms. The outcome measures included medication adherence, clinical outcomes, healthcare utilization, and cost-effectiveness. The results of the review indicate that pharmacists' MTM can significantly improve medication adherence, clinical outcomes, and healthcare utilization in various patient populations. The effect sizes were generally moderate to large, suggesting meaningful clinical benefits. The costeffectiveness of MTM was also demonstrated in some studies, indicating potential savings in healthcare expenditures. However, the heterogeneity of the studies and the limited generalizability of the findings pose some challenges in interpreting the results. In conclusion, pharmacists' MTM has shown promising results in improving patient outcomes and reducing healthcare expenditures in various settings. Further research is needed to determine the optimal MTM models, the most effective interventions, and the long-term sustainability of the benefits. The findings of this review can inform healthcare policymakers, clinicians, and researchers in designing and implementing MTM programs that meet the needs of patients and healthcare systems. Keywords: Medication therapy management, pharmacists, patient outcomes, healthcare costs, randomized controlled trial, chronic conditions, medication adherence, patient satisfaction, drug therapy problems, clinical outcomes. ASSESSING THE EFFECTIVENESS OF PHARMACISTS' MEDICATION THERAPY MANAGEMENT IN IMPROVING PATIENT OUTCOMES AND REDUCING HEALTHCARE EXPENDITURES: A COMPREHENSIVE REVIEW ICLTIPB/PH/2023/10216 Aditi Gaur, Sandeep Kumar School of Commerce & Management, Career Point University, Kota, Rajasthan, India. [email protected]
145 Souvenir Souvenir 146 Abstract: Patent is an exclusively right of a person who invents products or a new process of making a product or article it also includes improvement of an existing article. The first legislation in detailed in India related to patent was the Patent and Design Act, 1911. In M/s. Bishwanath Prasad Radhey Shyam v. Hindustan Metal Industries (AIR1980) the Supreme Court explain the object of Patent law is to encourage scientific research technology and industrial progress. In India Patent law has been modified in accordance with Trips agreement. A compulsory License can be issue in Indian Patent Act by Government on relevant grounds as reasonable requirement of the public. The reason of granting a compulsory license can be reasonable requirement of the public, patented products not available at reasonable price and product not available in India. The object behind of this to improve access to medicines to public at affordable price as public health is always being a primary concern of every country. In 2005 according to the amendment made in Indian Patent Act section 92A provides compulsory license for export pharmaceutical products. Compulsory License also can be grant in the condition of national emergency or extreme urgency. This article will discuss the legal provisions relating to compulsory license in India under Indian Patent Act and challenges and Conditions which impact compulsory license and its requirement for access of Medicines. The article further discuss the procedure of granting compulsory License in India. Keywords: Compulsory Licensing, Pharmaceutical Products, Technology, Improvement. COMPULSORY LICENSING OF PATENT IN INDIA: BALANCING INTELLECTUAL PROPERTY RIGHTS AND PUBLIC HEALTH CONCERNS ICLTIPB/PH/2023/10218 Kunal Rohira Amity Law School, Amity University Rajasthan [email protected] Abstract: Gagron, A unique confluence of cultural heritage, religion and environmental protection. Surrounding by two rivers i.e. Kalisindh and Ahu by three sides of fort, a fort without foundation, Gagron Fort was declared as World Heritage site in 2013, at the 37th session of the World Heritage committee by UNESCO. According to UNESCO the world heritage convention is one of the most successful instruments to protect the most extraordinary natural places on the planet characterized by their natural beauty or outstanding biodiversity, ecosystem and geological values. Primary Data collected from scholar's field survey at Gagron fort, Gagron village, Mukundara (Dara) hill area, Kalisindh and Ahu riverside and direct contact to local people. Secondary data collected from Forest department, range- Jhalawar, Gagron and Dara, Tourism department Jhalawar, library and journals. Plant are collected for Identification and herbarium preparation. Survey was conducted between December 2022 and February 2023. Author survey the plants and find some very important medicinal plants that naturally grows in those are e.g. Bryonia laciniosa (Shivlingi) – Uterine Tonic, Asparagous (Shatawari), Withania somnifera (Ashwagandha) etc. Author finds 26 rare medicinal plants also which have significant properties and traditionally used by local peoples. Keywords: Gagron, World heritage, UNESCO, medicinal plants. STUDY OF MEDICINAL PLANTS OF GAGRON FORT AND ITS ENVIRONS ICLTIPB/PH/2023/10217 Divyendu Sen, Shuchita Jain Department of Botany, J.D.B. Govt. Girls College, Kota, Rajasthan, India [email protected] Abstract: Treating cancer with combinations of drugs can be more effective than using a single drug. However, figuring out the optimal combination of drugs, and making sure that all of the drugs reach the right place, can be challenging. MIT chemists have designed a bottlebrush-shaped nanoparticle that can be loaded with multiple drugs, in ratios that can be easily controlled. Using these particles, the researchers were able to calculate and then deliver the optimal ratio of three cancer drugs used to treat multiple myeloma. The researchers showed that nanoparticles carrying three drugs in the synergistic ratio, identified to shrink tumors much more than when the three drugs were given at the same ratio but untethered to a particle. This nanoparticle platform could potentially deliver drug combinations against a variety of cancers, allows the drugs to accumulate at the tumor site and reduces toxic side effects. However, only a handful of nanoparticle drug formulations have received FDA approval to treat cancer, and only one of these particles carries more than one drug. The main focus was on the shape of these nanoparticles. The researchers gave the molecule a bottlebrush shape. To make the particles, drug molecules are inactivated by binding to polymer building blocks and then mixed together in a specific ratio for polymerization. This forms chains that extend from a central backbone, giving the molecule a bottlebrush-like structure with inactivated drugs -- prodrugs -- along the bottlebrush backbone. Cleavage of the linker that holds the drug to the backbone release the active agent. A proteasome inhibitor (bortezomib)-based BPD monotherapy slows tumor progression in vivo and the mixture of Bortezomib, Pomalidomide and Dexamethasone BPDs exhibit invitro synergistic, additive or antagonistic patterns. Johnson's lab is also working on using these particles to deliver therapeutic antibodies along with drugs. "The versatility of this platform gives us endless opportunities to create new combinations," he says. Our result offers design principles for combination of nanomedicines and strategies for improving current monotherapies and combination therapies for multiple myeloma. Keywords: Myeloma, Nanoparticle, Bottlebrush, BPDs monotherapy. MOLECULAR BOTTLEBRUSH PRODRUGS AS MONO-AND TRIPLEX COMBINATION THERAPIES FOR MULTIPLE MYELOMA ICLTIPB/PH/2023/10219 Hasan Shumayel, Yogi Riya, Meghvanshi Madhuri, Parveen Shama Department of Pharmaceutics, Kota College of Pharmacy, Kota, Rajasthan [email protected] Abstract: The aim of the present study were to formulate and evaluate Tamoxifen nanosponges for targeted delivery. Nanosponges were prepared using ethyl cellulose as the polymer and polyvinyl alcohol as the stabilizing agent by the solvent evaporation method. The Nanosponges prepared were evaluated for different parameters like the drug: polymer ratio, stirring speed, and time. The encapsulation and diffusion study of the formulation was done. Particle size analysis and scanning electron microscopy of the nanosponges were performed and this study found that the nanosponges were spherical in shape and have porous nature. The nanosponges prepared were incorporated into the gel base of carbapol. In the diffusion study of the nanosponges, gel was performed. Similarly, F6 and F7 exhibited the best release of 90.19% and 87.10% respectively at the end of 48 hours among all the five formulations of Tamoxifen – eudragit nanosponges. Keywords: Tamoxifen, Nanosponges, Solvent Evaporation Method. DESIGN AND CHARACTERISATION OF TAMOXIFEN NANOSPONGES FOR TARGETED DRUG DELIVERY ICLTIPB/PH/2023/10220 K. Kranthi Kumar Dept. Pharmaceutics College of Pharmaceutical Sciences, Dayananda Sagar University Bengaluru, Karnataka 560049, India. [email protected]
147 Souvenir Souvenir 148 Abstract: Food technology is the branch of science that includes aspects like production, preservation, research and development of food products. Be it Nicola Appert's decisive discovery of canning procedure or the discovery of pasteurization by Louis Pasteur, easily measures have been taken to preserve the food products and hereby prevent their spoilage. These discoveries have served as the foundation pillars to the now developed field of food technology. Food Scientists and technologists apply scientific disciplines including chemistry and microbiology to the study of food to improve the safety, storage and availability of the food. Depending on their area of specialization, food scientists may develop ways to preserve, process and store food according to industry and government specification and regulations. In the 21st century, emerging technologies have included cellular agriculture, 3D food printing and use of insect protein. Keywords: Food technology, canning, food sciences, 3D food printing. FOOD TECHNOLOGY ICLTIPB/PH/2023/10222 Parth Gurjar, Bhanu Pratap Singh Department of Pharmacy, University of Kota, Kota, Rajasthan [email protected] Abstract: Drug discovery is a process aims at identifying a compound therapeutically useful in curing and treating disease. This process involves the identification of candidates, synthesis, characterization, validation, optimization, screening and assays for therapeutic efficacy once a compound is selected for investigation, it will initiate the process of drug development earlier to clinical trials. The new drug must complete several tests before it get to the consumer. Over all the development of new drug take sufficiently long time its complex and also very expensive. A large number of molecules are screened out and only a single molecule gets approved in later stage of clinical trials and finally made obtainable for patients. It takes many years, for a raw drug to get approved as a medicine and requires heavy investment. The success ratio is also very low. The drug development phase involves stringent testing and optimization of the selected compounds to identify the 'most suitable drug candidate' which should be the most effective in terms of safety, toxicity and efficacy. This part of the development process is called preclinical phase. The phase followed by clinical phase of development consists of 3 phases: Phase I: perform the initial human testing in a small group of healthy volunteers, Phase 2: involves testing on a small group of patients, Phase 3: includes testing on a large group of patients to show safety and efficacy of the drug candidate in them. Since the health and sich people have potentially different metabolic patterns for the drugs. As we can see the need for new medicine is increasing day by day, this will also cause an increase in need of new drugs that will lead to new drug discovery and growth of sector as the time passes. Keywords: Clinical trials, validation, most suitable drug canditate, efficacy. DRUG DISCOVERY AND ITS DEVELOPMENT ICLTIPB/PH/2023/10221 Rahul Suman, Bhanu Pratap Singh Department of Pharmacy, University of Kota [email protected] Abstract: Artificial intelligence technology (AI) is a broad term to explain computers displaying human-like intelligence. The purpose of using AI technology is to treat people who require quality treatment to perform normal tasks on a daily basis. Like- “Stroke” patient. “Upper and lower limb” injured people. Patient with “Cerebral palsy” ,”Spinal cord injury “ and “Parkinson's disease”. Firstly, patient get assessed by therapist and then therapist must set plan for patient, then by the following the particular treatment, he /she regain their normal functions. As a result, there are a variety of reasons to use AI devices in therapeutic systems, because these technologies are Successfully cure humans. Robotics in physiotherapy improves the treatment procedure by helping patients getting assisted by robotics. Conclusively, using AI technology can deliver quality treatment. Keywords:AI, Cerebral Palsy, Robotics, quality treatment. ARTIFICIAL INTELLIGENCE IN PHYSIOTHERAPY ICLTIPB/PH/2023/10223 Damini Pareta, Kanchan Kholiya Department of Physiotherapy, Career Point University, Kota, Rajasthan [email protected] Abstract: Drug delivery systems are polymeric carrier systems that transport their targets or receptor sites in a manner that provides the maximum therapeutic activity, and prevent their degradation. For centuries, drugs have been used to the treat ailments, and improve health extend the lives. The substances used as drugs have greatly from the mixtures of different medicinal plants and other ingredients found in the ancient times. As the science of drugs and medicine developed into the broadly researched & tested chemical compounds that the pharmaceutical companies produce today, this ways in which these drugs can be delivered to the patients has evolved as well. The idea of how patients would receive these some medications, however, was not a widely discussed topic until the past few decades. Advancements in drug delivery have vastly changed the landscape of the effectiveness and medications, and even greater changes are anticipated for the near future. A drug delivery system is defined as a formulation which presents a drug to the body for administration and absorption. The main goal of using drug delivery systems is to provide a therapeutic amount of medication while improving efficacy & safety by controlling location, rate, and time of release particular drug in the body. Drug delivery systems have greatly evolved over the last six decades. In this last 15 years specifically, there have been best advancements in drug delivery technology. For example, advanced medication delivery systems, and transdermal patches, are able to deliver a drug more selectively to a specific site. which frequently leads to easier, more accurate, and less dosing overall. Drug delivery devices such as drug absorption and more consistent with the site and mechanism of action. Keywords: Drug delivery systems, transdermal patches, polymeric. DRUG DELIVERY SYSTEM ICLTIPB/PH/2023/10224 Shagun Gupta, Ramesh Kr. Singh B.N. College of Pharmacy Lucknow ( U. P.) [email protected]
149 Souvenir Souvenir 150 Abstract: Peptic ulcer is the most prevalent gastro-intestinal disorder and has been a major health problem with a high rate of global incidence. The basic cause of peptic ulcer has not been understood until the recent times. In the early 20th century, peptic ulcer disease was believed to be related to excessive acid secretion resulting from stress full lifestyle. Important advances have occurred in the last two decades that improved our understanding for the disease and as well improved our therapeutic strategies. The major forms of peptic ulcer include gastric and duodenal ulcer both of which are chronic in nature. Gastric ulcer is a very common global problem today. The pathophysiology of ulcer involves an imbalance between offensive (acid, pepsin, and Helicobacter pylori) and defensive (mucin, prostaglandin, bicarbonate, growth factors and nitric oxide) factors. Drugs from native sources of natural products are thus now a target for development, refinement and pharmacological modification for anti-ulcer treatment. Evolution of Ayurveda and plantbased remedies for health care through day-to-day life experiences is a part of the cultural heritage of India. Various Indian medicinal plants have been reported to possess antiulcer activity. There are various medical uses of Pistia stratiotes throughout regions in Asia and Africa. Keywords:Peptic Ulcer, Gastric Ulcer, Pistia Stratiotes. A REVIEW ON ANTI-ULCER ACTIVITY FROM PISTIA STRATIOTES ICLTIPB/PH/2023/10226 Ravi Gupta, Shubhanshu Singh, Chetan Kumar Dubey, Abhishek Nagar Career Point School of Pharmacy, Career Point University, Kota, Rajasthan, India [email protected] Abstract: Oral drug delivery is always a simplest and oldest method for drug Administration as compare to other painfull treatment (Injection)for Diabetes management. new researcher (MIT)develope a Capsule Pill for delivery of Insulin to patient for avoid painfull Medication. Delivery of Insulin in Pill form is dream for Diabetes researcher, but after decades of trying there has been some achievements related to these. Type 1 Diabetes always treated by Injection that is painfull treatment and discomfort for Child & patient having needle Phobias. In these delivery sugar coated pill dissolved in body & release Insulin directly to Stomach lining needles release Medicament to Stomach and reach to blood circulation to maintain insulin levels in body. These research are replacement of injection therapy. These needles are made by Biodegradable material to dissolve in body fluid. Keywords: Insulin, Types, Needles Internal structure, Injection, Treatment RESEARCH OF ORAL PILL DISCOVERY FOR INSULIN DRUG DELIVERY ICLTIPB/PH/2023/10225 Jyoti Nagar, Madhuri Meghwanshi, Jagdish C. Nagar Kota College of Pharmacy, Kota, Rajasthan [email protected] Abstract: Globally Diabetes mellitus (DM) is one of the most prevalent diseases. DM is a prolonged disease caused by inherited and or acquired deficiency of pancreatic insulin production, or due to the inefficacy of the insulin. DM is characterized by multiple defects in its pathophysiology and abnormalities in carbohydrates, lipids proteins, and metabolism. It is evident that this disease leads to hyperglycemia and to many other complications such as atherosclerosis, hypertension, hyperlipidemia, neuropathy, retinopathy, and nephropathy. DM depends on several factors such as alterations of people lifestyle, behaviour and environment. Diabetes is a syndrome characterized by disordered metabolism of carbohydrate, protein and lipid with abnormally high blood sugar resulting from low levels of the hormone insulin with or without abnormal resistance to insulin's effect. Diabetes mellitus is considered as one of the five leading causes of death in the world. Traditional medicines most often apply to plants are being employed as adjuvants in the management of diabetes mellitus in many of the Asian countries including India. India has a rich history of using various potent herbs and herbal components for treating diabetes. Keywo rd s : Di a b e te s Me l l it u s , Hy p e rg l yc e m i a , Hyperlipidemia. A REVIEW ON INDIAN MEDICINAL PLANTS IN DIABETES MELLITUS ICLTIPB/PH/2023/10227 Shubhanshu Singh, Ravi Gupta, Chetan Kumar Dubey, Abhishek Nagar Career Point School of Pharmacy, Career Point University, Kota, Rajasthan, India [email protected] Abstract: Herbal drugs are important part of alternative traditional medicines practice mainly in Southeast Asia. The origin of ayurvedic medicine, which is mainly herbal medicine, dates back to about 1200 – 500 BC as evidence by its original compendia basis – Atharvaveda, Charaka Samhita and Sushruta Samhita. Development of herbal drugs and their characterization pose several challenges especially those of correct identification, quality control and evidences of safety and efficacy that would be acceptable to contemporary regulatory agencies. Chromatography or genetic fingerprinting (wholesome but unique characterization of these herbs) offers a substantial solution to these challenges. Fingerprinting covers identity, consistency, authenticity and in some cases even quantitative measurements of fingerprinted constituents. Hyphenated chromatographic techniques (LC-MS, LCMS/MS or GC-MS) have demonstrated great performance in terms of stability of retention time, selectivity, sensitivity, resolution and precision. Herbal drugs can modulate several target s ( sys tems , end organs , receptor s , etc.) simultaneously in the body. Inverted to understand better the molecular mechanism of herbal drug action, analyses of gene expression seems obviously necessary. DNA microarrays provide high throughput analyses of multiple genes, which are involved either in the expression of diseases or in diagnosis, prognosis, regulation of their biomarkers and even cure of those diseases. Keywords: Hyphenated techniques, Herbal drugs, DNA microarray, Fingerprinting, Ayurvedic medicine. HYPHENATED TECHNIQUES FOR FINGERPRINTING OF HERBAL DRUGS ICLTIPB/PH/2023/10228 Uttam Singh Baghel Gurukul Pharmacy College, Kota (Rajasthan) [email protected]
151 Souvenir Souvenir 152 Abstract: Any change in the physical, chemical and biological properties of water that has a harmful effect on living things. Ra p i d g rowt h of p o p u l a ti o n, u r b a n i z a ti o n a n d industrialization exerts pressure on water resources and unregulated or illegal discharge of effluents results in water pollution. The fast development of populace joined with rising degrees of utilization and contamination has expanded water frailty in India The Mahi Bajaj Sagar lies in village Borekhera about 16 Kms. North East of Banswara town and is one of the biggest artificial Dam in South Rajasthan having the catchment area of 6149.00 sq. Kms. The morphometric features of the Mahi Bajaj Sagar indicate that it a deep reservoir with a maximum depth of 75 meters. The physico chemical qualities were determined using the methods described by APHA. The mean values of the physicochemical parameters of water qualities analysed are air temperature-32.34ºC, water temperature-26.30ºC, depth of visibility-240.65cm, pH-8.45 dissolved oxygen-10.21 mg, free CO absent, carbonates-10.86 mg, bicarbonates-50.53 mg total alkalinity-61.4 mg lnitrate-N-0.20 mgl, orthophosphates-0.33 mg lThe water quality of Mahi Bajaj Sagar is low polluted. On the basis of physico-chemical characteristics, Mahi Bajaj Sagar is alkaline and moderately hard water body. The water quality parameter indicated the suitability of Mahi Bajaj Sagar for fishery purpose The present investigation done in mid January 2022. Keywords: urbanization, Mahi bajaj sagar, alkaline, bicarbonates. A COMPARATIVE STUDY OF STATISTICAL ANALYSIS OF PHYSIO-CHEMICAL PARAMETERS OF WATER OF DHOLAWAD DAM & MAHI BAJAJ SAGAR DAM ON MAHI RIVER ICLTIPB/PH/2023/10230 Neha Kaithwas, Surbhi Singh School of Basic and Applied Sciences, Career Point University, Kota, Rajasthan, India [email protected] Abstract: In this describes the significant regulatory aspect for clinical research to international traditional herbal medicine research. Herbal medicines are naturally occurring, plantderived substances with minimal or no industrial processing that have been used to treat illness within local or regional healing practices. Herbal medicines are getting significant attention in global health debates. Governments, international agencies and corporations are increasingly investing in traditional herbal medicine research. Yet some literature addresses ethical challenges in this research. This deals about three key, under approachable dimensions of the ethical aspect in which particularly difficult questions arise for international herbal medicine research: social value, scientific validity and favorable risk–benefit ratio. Many considerable challenges exist in determining shared concepts of social value, scientific validity and favorable risk–benefit ratio across international research collaborations. By investing in safety-monitoring infrastructure, “cross-training” investigators, and the issues identified by this significant framework can promote ethically strong international herbal medicine research that contributes to world health. Keywords: Herbal medicine, Clinical research, Regulatory aspects, Safety-monitoring. REGULATORY ASPECTS OF HERBAL MEDICINE ICLTIPB/PH/2023/10229 Kapil Sharma, C.K. Dubey, Abhishek Nagar, Harshita Jain Career Point School of Pharmacy, Career Point University, Kota, Rajasthan, India [email protected] Abstract: It is evident that viruses pose a significant risk to human health, and the rate of emergence of new pathogenic viruses has increased over the years. If we consider a new strategic method called drug repurposing then we came to understand that it is a promising, fast, and low-cost method of overcoming the traditional challenges of new drug discovery and development for treating a variety of diseases and disorders. Drug discovery shows an evolutionary pattern in various strategies developed over decades. Drug repurposing (DR) (also known as drug repositioning) is the process of discovering new therapeutic applications for previously used/existing/available drugs. Drug molecules with new pharmacological/ therapeutic indications will be developed or discovered using this strategy. In these recent years, disease outbreaks have been observed very frequently with variations in the biochemical pathways, so more consideration and devotion were put into synthesizing and formulating new molecules in a bioactive way to combat diseases. The promising drugs candidate are successfully identified using drug repurposing that has the potential to open up new therapeutic avenues for battling current viral pathogens as well as new emerging viruses. Generally, three approaches are commonly used in drug repositioning and they are computational approaches, biological experimental approaches, and mixed approaches. In between all the scientific studies, many promising drug candidates for various viral infectious diseases are obtained from drug repurposing like Ebola virus (EBOV), Zika virus (ZIKV), West Nile virus (WNV), yellow fever virus (YFV), dengue virus (DENV), henipaviruses (Nipah, Hendra), SARS-CoV, Middle East respiratory syndrome (MERS-CoV), Lassa virus (LASV), Crimean-Congo hemorrhagic fever virus (CCHFV), HIV, Rift Valley fever virus (RVFV), chikungunya virus (CHIKV), and Influenza virus with many viruses causing numerous infectious diseases. Numerous drugs on the market have been tested for their extensive use as broad-spectrum drugs for antiviral treatments. At this point, it is dire need that researchers must adopt new approaches to drug repurposing. This review will describe the recent efforts to find broad-spectrum antivirals through drug repurposing. Keywords: COVID-19, Drug repurposing, pharmacological, antiviral, pathogens. “OLD DRUGS - NEW METHODS”- A REVIEW ON ANTIVIRAL DRUG REPOSITIONING ICLTIPB/PH/2023/10231 Roma Sharma, Surabhi Singh School of Basic and Applied Sciences, Career Point University, Kota, Rajasthan, India [email protected] Abstract: Water hyacinth (Eichhornia crassipes) is an invasive aquatic macrophyte that creates several problems in the irrigation system of rivers. To study the control of their rapid distribution in water bodies, the biological control method was carried out by employing the weevil Neochetina eichhorniae in an experimental site i.e Ayana pond, Kota, Rajastahn. The study demonstrates the effectiveness of weevil in controlling the rapid population of water hyacinth at experimental site. When compared to the first release in the field, the weevil intensity was increased in numbers. Active scraping was observed in the leaves and decay spots were seen in the stems of the weed. Neochetina eichhorniae were introduced biyearly at the experimental site for one year. During the observation period, stunted growth and reduced population were observed in the study site. The study highlights the importance of Neochetina eichhorniae on the Growth, Propagation, and Spread of Eichhornia crassipes. Keywords: Macrophyte, Eichhornia crassipes, Neochetina eichhorniae. THE EFFECT OF NEOCHETINA EICHHORNIAE ON THE GROWTH OF EICHHORNIA CRASSIPES AT AYANA POND, KOTA, RAJASTHAN ICLTIPB/PH/2023/10232 1 2 3 Arun jatav , A.K. Sharma , Smriti Johari 1,2Department of Zoology, Career Point University, Kota, Rajasthan 3 Department of Zoology, J.D.B Girls College, Kota, Rajasthan [email protected]
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