Quality
Consistency
Commitment
PFANSTIEHL LAUNCHES HISTIDINE AND HISTIDINE HCI
HIGHEST PURITY, LOWEST ENDOTOXIN, LOWEST METALS
• Trehalose • Mannitol
• Sucrose • Galactose
• Histidine • Mannose
• Histidine HCI • Maltose
• Arginine • Sodium
Succinate
USA MANUFACTURING • MULTICOMPENDIAL • cGMP PRODUCTION
ICH Q7 COMPLIANCE • ICH Q3D COMPLIANCE ON SPECIFICATIONS
USA Telephone: 1.847.623.0370 • Toll Free Telephone: 1.800.383.0126
International Telephone: +41 41 755 40 54 • Email: [email protected]
RNI No. DELENG/2004/13061 Published on 28th of previous month PCW/193/2020-2022
Posting Date: 30th of every month Posted at Ex Servicemen Colony PO, Pune-38
Cellicon™ Perfusion Filter Cellicon™ filter effectively
and Controller retains cells while
maximizing throughput.
A Superior Cell Retention Solution for Seed Train Its unique design ensures
Intensification with Optimized Process Control predictable and linear scale
up and scale down from
the bench to production.
This simple and easy-
to-use solution is up and
running in minutes.
CelliconTM
Perfusion Solution
Fresh
Media
Spent
Media
Mobius® 3 L
Bioreactor
Process intensification is driving a wider adoption of perfusion Precise management of
based cell cultures in biopharmaceutical manufacturing providing the perfusion process is
manufacturers with an opportunity to reduce CoGs while ensured by the Cellicon™
increasing protein yields and productivity. However, perfusion controller through an
still presents manufacturers with critical productivity challenges intuitive interface. Flow
that are often associated with the performance limitations of control maintains
current cell retention technologies. The development of a novel consistent crossflow and
cell retention technology for intensified seed train operations pressure, while ensuring
offers significant productivity improvements and yield for today’s balanced polarization and
perfusion processes. reproducible performance
from run to run.
Cellicon™ Perfusion Solution has been specifically designed
for N-1 intensified seed train applications. It consists of a cell • High throughput and low fouling
retention single-use assembly and controller.
• Predictable linear scale-up from lab to
Viable Cell Density (E6 cells/mL), 120 manufacturing scale
Viability (%), and Doubling Time (hours)
100 • Reliable and reproducible performance
80 • Low crossflow and cell shear
60 • Comprehensive monitoring and precise control
40 • Ready to process in minutes
20
0 56 7
01234 Doubling Time
Duration (days)
Viable Cell Density Viability
Learn more at For more information, please contact:
MerckMillipore.com/Cellicon Email: [email protected]
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