Amsterdam Rotation Protocols Dr H Training

Commonly Used Botanicals For Sleep

◼ Melatonin: 1-10 mg (↓ IL-17). Watch for hangover

◼ Cerenity PM: Designs For Health: 2 HS

◼ Herbsom: TCM (Zhang): 2 HS

◼ Valerian Root: Xymogen’s SynovX Calm: 2 HS

◼ Kavinase: 2 HS

◼ Honokiol: 2 HS (also for Candida, neuromodulation)

◼ GABA-L theanine (cream [Xymogen], oral
version=Relax Max [Xymogen or L-theanine cap’s])

◼ Magnesium: Optimag Neuro (Xymogen): 1 scoop

◼ Lingmei Sun, et al. Honokiol induces reactive oxygen species mediated apoptosis in Candida albicans
through mitochondrial dysfunction. PLoS ONE 12(2): e0172228; Woodbury, A., et al.
Neuromodulating effects of Honkiol: A review. Front in Neurology, Sept 2013

VIII. Emotional Trauma/PTSD With
Extreme Hypersensitivity

◼ Apart from standard therapies (CBT, EMDR, Neuro-
feedback), counseling, meditation, medication…

◼ Annie Hopper’s DNRS program: limbic retraining: 15-60
min’s/day: www.retrainingthebrain.com: see testimonials

◼ CFS/FM/MCS/EMF sensitivity/POTS/Lyme-MSIDS share a
common denominator: limbic system impairment

◼ For MCS, Mold, Food sensitivities, chronic pain, POTS, CFS,
FM, Sensitivity to light, sound, smell, EMF Sensitivity,
depression, anxiety, Lyme… People who did it improved
fatigue, can eat diff foods, recovered from POTS, Lyme
symptoms got better, w/ better mood/happiness.

Annie Hopper: DNRS Program,

Hopper ISEAI, 2019

IX. Resistant POTS/dysautonomia

◼ Get to the source(s) of the problem: Lyme, co-

infections, toxins (mold), MCAS, CDR, ? EDS (Ehler Danlos)

◼ Treat symptomatically: salt (tablets, 3 gm ++), Licorice

+, 2 am, > 2-3 liters of fluid/day
◼ Florinef (fludrocortisone) 0.1 mg am. Raise dose as needed
◼ Midodrine: start 5 mg TID, ↑ 10 mg TID if BP not controlled

or w/ resistant symptoms (dizziness changing position, pre-
syncope, syncope, fatigue, palpit’s, anxiety, brain fog)
◼ Add Northera (droxidopa) 100 mg TID, ↑ by 100 mg TID Q
2 days, max dose 600 mg TID. Check supine BP w/meds
◼ TED support stockings? Cardio PT/rehab?
◼ Annie Hopper DNRS, Vagal retraining, Address CDR

X. Mitochondrial Dysfunction:
Cell Danger Response (CDR)

◼ Cell Danger Response (CDR, Robert Naviaux): Persistent
CDR creates blocks in healing. The path from chronic
illness to healing has a beginning, middle and end.

◼ Mitochondria have 3 developmental forms that undergo
programmed interconversion when a cell is
injured/stressed

◼ Beginning, M1: proinflammatory form for defense

◼ Middle, M0: uncommitted form for growth and biomass
replacement

◼ End: M2: anti-inflammatory form for general conditions

◼ The Metabolic Features and Regulation of the Healing Cycle. Naviaux RK. Mitochondrion, September
2018.



X. Mitochondrial Dysfunction:
Cell Danger Response (CDR)

◼ The CDR coordinates mitochondrial (f) after injury

◼ Healing cycle is a genetically programmed 3 step process

◼ Metabolism controls progression through the healing
cycle by using metabolites as ‘signaling molecules’
(metabokines): extracellular ATP is important at all stages

◼ When the CDR is chronically activated, the coordination
between the two limbs of the vagus is disrupted. This
results in disinhibiting the sympathetic nervous system
and the HPA axis which dominate during illness.”

◼ Metabolic features of the cell danger response. Naviaux RK. Mitochondrion, 2014 (ePub 2013).
◼ “Vagal influences over mast cells” Stead, R, et al. Anatomical Neuroscience: Basic and Clinical, 125

(2006) 53-61;

XI. Genetic Evaluation: Why Won’t the
Patient Get Better?

ISEAI talk, Bob Miller, May 2019: www.yourgeneticresource.com

◼ Bob Miller: Nutrigenetic Research Institute (200k SNP’s)

◼ Genetic weakness & epigenetic factors can impact detox
ability and increase inflammation

◼ This inflammation leads to an imbalance of mTOR
(growth) and Autophagy (cleaning)

◼ This may lead to excess mast cell activation and heme
dysregulation, consequently, using up antioxidants and
NADPH to neutralize the free radicals→ NADPH Steal

◼ NADPH can be used by NOX to make inflammation, and
less NADPH is available for reducing (recycling)
antioxidants.

Why Check Genetic Pathways and
NADPH?

◼ NAD (including NAD+ and NADH) and NADP (including
NADP+ and NADPH) mediate:

◼ Energy metabolism + Mitochondrial functions

◼ Antioxidation/generation of ROS

◼ Gene expression

◼ Immunological functions

◼ Aging + Cell death

◼ Can look at SNP’s for potential NADPH Steal: Nutrigenetic Research
Institute does a functional genetic analysis w/ cloud based software
to interpret SNP’s, + customized formulas
www.nutrigeneticresearch.com

Putting It Together: Crucial Steps in
Healing the Difficult to Treat Patient

◼ Evaluate and treat MCS and detoxification problems
◼ Evaluate and treat GI abnormalities
◼ Evaluate and treat chronic persistent infections and toxins,

which may be driving MCAD and vagal nerve dysfunction
w/POTS/dysautonomia. Use limbic + vagal retraining, esp.
when PTSD/chronic illness is present (reset the system)
◼ Evaluate and treat immune dysfunction (under/overactive)
◼ Evaluate and treat sleep disorder(s)
◼ Evaluate and treat genetic abnormalities and mitochondrial
dysfunction w/abnormal CDR

Thank you….