Garrison Institute on Aging

Garrison Institute on Aging
ANNUAL REPORT 2010

About the GIA

The Garrison Institute on Aging (GIA) is the corner-
stone of the TTUHSC initiative in aging. From inves-
tigating the causes of neurodegenerative diseases
to preparing health care professionals for the grow-
ing demands of geriatric care, the GIA is addressing
health issues of the aging population. The GIA is a
collaborative initiative of the Health Sciences Center
schools: Allied Health Sciences, Medicine, Nursing
and Pharmacy.

Garrison Institute on Aging Learn more about the Garrison Institute on Aging

Editor On your mobile browser, download the free app
Amy Crumley, M.B.A. for your smart phone at http://gettag.mobi. Then, with

Layout and Design the app open, scan the quick response tag above.
Jason LeMaster

Contributing Writers
Annette Nichols Boles, MS
Diane Botello, RN
Jessica Bowley, RN, BSN
Paula Grammas, Ph.D.
Bradley Miller, M.D., Ph.D.
Debjani Tripathy, Ph.D.





Director’s Report before and after program participation to assess the ef-
fects of exercise and nutrition on overall health.
This past year has proved to be another exciting year of It is our firm belief that we, with your help, can make
growth and change at the Institute. During the past year, a difference in improving the quality of life for Texans
we recruited Dr. Bradley Miller to the Institute. Brad is and all Americans. I hope you enjoy this publication and
an energetic, enthusiastic physician-scientist with train- that you will continue to travel with us on our journey
ing in neuropathology. He is The CH Foundation Chair of discovery.
in Parkinson’s Disease and Associate Executive Director With gratitude,
of the Institute.
Paula Grammas, Ph.D.
On the scientific front, we are working to understand the GIA Executive Director
enigma that is Alzheimer’s disease. Our scientific focus
on the road-less-traveled in Alzheimer’s disease research 3
has led to novel observations that may open new ave-
nues for therapies for this devastating disease.

The education division of the Institute continues training
for the long-term care workforce. Our staff has devel-
oped a state-of-the-art educational program for Certified
Nurse Aides in Medications to better prepare these pro-
fessionals for the growing needs of geriatric medicine.

Our community outreach division leads the way help-
ing Lubbock, and surrounding communities, learn about
healthy lifestyles and their important impact on longe-
ity and quality of life. Our program GET FiT Lubbock
recently wrapped up its first research project in which
over 150 participants were evaluated for health markers

RESEARCH

4

GIA researchers lead cutting-edge
research efforts to understand

Alzheimer’s disease and other diseases
of aging as well as to develop novel

therapeutic approaches to cure and/or
prevent age-related disorders.

5

Photo:

6 Riannon Rowley

GIA welcomes Bradley Miller, M.D., Ph.D.

Bradley Miller, M.D., Ph.D. was recently recruited to The Miller earned his bachelor’s degree from the College of
CH Foundation Regents Chair in Parkinson’s Disease Re- William and Mary in Virginia. He received combined phy-
search, Associate Executive Director of the Garrison In- sician-scientist training at Virginia Commonwealth Uni-
stitute on Aging and assistant professor in the TTUHSC versity, completing his medical degree from the School
Department of Pathology. of Medicine and his Ph.D. from the Graduate School of
Biomedical Sciences. His residency training in pathology
Miller previously worked as an adult and pediatric sur- and fellowship training in neuropathology were both at
gical and autopsy neuropathologist at the University of UVA.
Virginia (UVA) Health System. In addition, he had pri-
mary diagnostic and research responsibility for all neu- “What initially attracted me to Texas Tech is the school’s
rodegenerative disease cases. teamwork aspect in approaching research,” Miller said.
“The partnership with the GIA’s Brain Bank Program
As a physician-scientist and assistant professor in the allows for people with or without diseases such as Al-
TTUHSC Department of Pathology, Miller goes beyond zheimer’s or Parkinson’s to donate their brains for clini-
the diagnosis of disease to try to discover the origin of cal research upon death.”
the disease process and to identify new treatments based
on that information. He uses Laser Microdissection to
isolate areas as small as individual neurons from the
brains of patients who died of Alzheimer’s or Parkinson’s
disease.

“There is no substitute with being able to study an actual Above: (Left to right) TTU Chancellor Kent Hance, Brad Miller, M.D.,
human brain,” he said. “When dealing with diseases such Ph.D., TTUHSC President Tedd Mitchell, M.D. Far Left: Brad Miller, M.D.,
as Parkinson’s and Alzheimer’s, nothing beats going right Ph.D., holding a brain tissue sample.
to the source, which in the case of neurodegenerative
diseases is the human brain.”

7

Exploring new treatments for Alzheimer’s

Since prehistoric times, plants and their extracts have as an alternative source may lead to improved drugs,”
proved to be highly successful when used for their heal- Dr. Tripathy believes.
ing properties. Ancient Egyptians, for example, chewed
willow bark to relieve fever and headaches. Thousands Exciting preliminary results at the Institute show that
of years later, scientists discovered that the bark contains Withaferin A, a plant product of Withania somnifera,
salicylic acid, the active ingredient used to make Aspirin. prevents the release of toxic proteins that kill brain cells.
Dr. Tripathy’s future work will, in fact, determine wheth-
Debjani Tripathy, Ph.D., a post doctoral research associ- er this plant product helps slow the progression of Al-
ate at the Garrison Institute on Aging, is studying the zheimer’s disease.
effects of plant extracts, more specifically Withania som-
nifera, on brain nerve cells. This work has important
implications since brain nerve cell death is the cause of
Alzheimer’s disease.

Currently, the FDA drugs that are available for Alzheim- Above: Withania somnifera, the plant being studied for its promising ef-
er’s treatment have only modest effects in slowing the fects on Alzheimer’s disease.
progression of Alzheimer’s Disease. New therapeutic ap-
proaches are desperately needed. Withania somnifera,
commonly known as Ashwagandha or Indian ginseng,
has been used in herbal formulation for increased vigor
and longevity, as well as to treat disorders of the uterus,
arthritis and cancer.

“Exploring plant products, which were used in an-
cient times to cure age-related diseases and dementia,

8

Brain Bank Program

In order for researchers and medical practitioners to fully
understand Alzheimer’s disease, a neuropathology diag-
nosis on the brain must be performed. Since the creation
of the Brain Bank in January 2007, there have been 74
brains donated from around the United States.

This program helps families of dementia patients by
providing a free brain autopsy and also banks tissue for
qualified researchers studying dementia-related diseas-
es, such as Alzheimer’s.

This program is funded solely through private contribu-
tions. Families who have donated to the Brain Bank are
motivated by personal experience. Having been touched
by Alzheimer’s disease, they ultimately want to contrib-
ute funds that may one day cure or prevent this terrible
disease. Brain donation is a legacy for future generations.

Contact the Brain Bank office at 806-743-2408 for more
information or visit www.ttuhsc.edu/aging.

9

The Institute’s education division has
programs for students, health care
professionals and the general public to
increase knowledge and awareness of

age-related health care issues.

10

EDUCATION

11

Caregiver Education Services Diane Botello, RN
CNA Nurse Educator and Training Program Coordinator
The program’s mission is to enhance the health of older
persons by advancing best practices and professionalism Diane Botello, RN is the Director of the CNA Program for
in long-term care workforce training. LVNs and CNAs the Garrison Institute on Aging. Mrs. Botello has been a
represent the majority of the direct care workforce; Certified Nurse Educator for seven years and has been a
therefore, the Certified Nurse Aide and Medication Aide Registered Nurse for 23 years. “When I started as a nurs-
programs are targeted to nurses and nurse-aides to es aide many years ago, there wasn’t a formal training
program. It was on-the-job training, so the level of skill
• Advance geriatric care and professionalism was dependent on the person that trained you. As the
• Improve staff recruitment and retention health care shortage grew, the on-the-job training short-
• Improve the quality of care in nursing homes ened. This created an opportunity for substandard care.
I feel it is so important to correctly train the direct care
Medication Aide Course staff so that they will provide great care in any health
care environment.”
Recently added to the Caregiver Education Services this
year is the Medication Aide course. The Medication Aide
course trains and certifies nurse aides working in long-
term care to administer medication under the direction
and supervision of a nurse. Since there has been a short-
age of nurses in the last several years, using a medica-
tion aide helps to insure that residents are given their
medication in a timely manner. Statistics show that with
our aging population, more health care providers are
needed. The medication aide program will help to fill
that need in our area.

12

Educating the Lubbock Community

Jessica Bowley, RN, BSN The Healthy Aging Lecture Series is a monthly educa-
CNA and LVN Nurse Educator tional program for the public to learn more about inno-
vative research and health topics of interest to seniors.
Jessica Bowley, RN, BSN is a Registered Nurse with her The lectures take place September through May at the
BSN from Texas Tech University. Mrs. Bowely has been a TTUHSC Academic Classroom Building and focus on the
Registered Nurse for 11 years and has taught CNA cours- importance of taking care of the body, mind, and spirit
es for TTUHSC for over six years. “Working in the nurs- at any age. In 2010 the audience consisted of mostly re-
ing home at a young age sparked my love and apprecia- tired seniors, but many other health professionals, HSC
tion for our older generations. I hope through Caregiver students and researchers also attended the lectures to
Education Services we can offer CNA courses to a larger hear a variety of experts speak on how to improve their
population, as well as, teach more advanced care giving health and fitness.
topics such as the Medication Aide program to enhance
the quality of life of the frail elderly in long-term care Lectures 2009/2010
settings.” “The New Aging Paradigm”
“Glaucoma”
“Palliative Care”
“VNUS Procedure for Varicose Veins”
“Stroke-Diagnosis and Treatment”
“Memory Health and Dementia Disorders”
“Nutrition and Healthy Aging”
“Alzheimer’s-Identify, Causes, & Treatments”

13

Cochran County Community-Based Respite Program

The Cochran County Community-Based Respite Care Through the program, care recipients have had the op-
Program is designed as a cost-effective means of provid- portunity to interact with friends (volunteers) and par-
ing relief to family caregivers while enhancing the lives ticipate in a variety of activities including gardening,
of both caregivers and care receivers. The GIA in part- games and music. It is our hope that the community-
nership with the F. Marie Hall Institute for Rural and based respite program model will provide a foundation
Community Health, this program is focused on address- for the creation of a rural respite care network in West
ing the needs of those caring for individuals suffering Texas.
from dementia related diseases. Currently, no respite
network exists in West Texas.

Volunteers from the community provide respite services
for family caregivers once a week for four hours at the
Griffith Senior Citizens Center in Morton, Texas. The
program is provided to families at no cost and is sus-
tained by the support of community volunteers.

In Cochran County, family caregivers and volunteers Cochran County Community-Based Respite Program volunteers and partic-
have eagerly participated in the weekly respite program. ipants play Bingo at the Griffith Senior Citizens Center in Morton, Texas.
The respite services have succeeded in their intent to
provide family caregivers relief from their care giving
duties. The program has also succeeded in rekindling re-
lationships among elder residents in the community and
supporting the physical, social and psychological health
of care recipients.

14

Student Scholars in Geriatrics 2010 Student Scholars in Geriatrics
Sabrina Bridgers
The Student Scholars in Geriatrics program was estab- Tiffany Bunag
lished to develop a cadre of students from allied health
sciences, medicine, nursing and pharmacy who have a Jacqueline Gilchrist
long-term commitment to advancing health care for old- Abigail Kirk
er adults and are actively engaged in projects designed Tejas Ozarkar
to improve the quality of health care for the elderly. Dan Rhoads

Under the faculty mentorship of Andrew Dentino, M.D., Rebecca Tompkins
F.A.C.P., F.A.P.A., C.M.D., GIA Director of Clinical Geri-
atrics, these student leaders have initiated several proj- Student Scholars test the hearing of Heritage Oaks patient.
ects including:
15
• Interdisciplinary Health Assessments for commu-
nity dwelling seniors in which students perform as-
sessments relevant to their discipline then meet as
a group to compare their findings and make recom-
mendations.

• “Lunch and Learn” lecture events with expert
speakers on various aging health topics.

• Actively hold American Geriatric Society (AGS)
Student Chapter meetings for fellow classmates.
The AGS strives to enhance the visibility of geriat-
ric medical care, and to provide educational pro-
grams on geriatric health care.

COMMUNITY OUTREACH

16

GIA’s community outreach programs
in Lubbock and the South Plains

community serve to increase fitness
and nutritional awareness, and

highlight the importance of healthy
lifestyles in aging.

17

18

GET FiT Lubbock V kicks off to a great start

GET FiT V Lubbock kicked off on Saturday, August 28, This year GET FiT Lubbock offered a research compo-
2010, at the Texas Tech University Health Sciences Cen- nent. Those eligible in participating in the GET FiT re-
ter (TTUHSC) Garrison Institute on Aging. TTUHSC search received free pre and post health screenings (cho-
President Tedd L. Mitchell, M.D., Holly Betenbough, lesterol, blood pressure, blood sugar, height, weight,
Betenbough Homes and Curry Blackwell, Premier Sport- Body Mass Index, body fat percentage, and waist to hip
splex opened up the festivities and stressed the mission ratio) and payment for participating in the program. The
to promote a healthy lifestyle in the community. participants’ screening information will be used in future
grant proposals and publications measuring the effects
Over 200 people came out to the GET FiT Lubbock reg- of this program on their overall health.
istration kickoff which included events such as a bas-
ketball shootout with the Texas Tech University (TTU) GET FiT Lubbock V featured 146 teams consisting of 558
Men’s basketball team, tennis demonstrations with the participants who exercised 12,879 hours and lost 1,824
TTU Men’s tennis team, TTU Cheerleaders and Pom pounds. A big thank you goes to our sponsors; Premier
Squad, Coronado High School drum line, and informa- Sportsplex, Shropshire Agency and Betenbough Homes.
tional health booths. Since the inception of GET FiT Lubbock in 2007, 2,924
participants have exercised 77,000 hours and lost more
GET FiT Lubbock is an 8-week fun competition to help than 9,000 pounds.
people in the community meet their fitness and weight
loss goals. The competition includes exercise and weight Left: President Tedd Mitchell, M.D., addressing participants at the GET FiT
loss activities, encouragement and support from health V kickoff. Also pictured, Paula Grammas, Ph.D., GIA Executive Director;
and fitness professionals and free GET FiT lectures. Raider Red.
Teams of 4 people compete for great prizes donated
from local community businesses.

19

F.I.T. Tech & GET FiT Lubbock team up

The TTU Department of Nutritional Sciences Fitness, In-
formation, Technology Challenge and TTUHSC Garrison
Institute on Aging GET FiT Lubbock teamed up to en-
courage all of TTU, TTUHSC, and TTU System students,
faculty, staff, and spouses to gear up to exercise regu-
larly and eat healthy.
For the 8-week competition, 394 participants logged
10,599 exercise hours and lost a total of 1,245 pounds.
Participants were able to attend nutrition lectures and
webinars each week and also attend a variety of fun ex-
ercise events such as tennis rallies and a Palo Duro Can-
yon hike.

Center: F.I.T. Tech kickoff inspires participants to eat healthy and exercise
regularly.

20

Fit for Life focuses on senior health

Texercise is a statewide fitness program developed by
the Department of Aging and Disability Services (DADS)
to educate and involve senior Texans and their families
in physical activities and proper nutrition. Texercise
helps promote a healthy lifestyle, minimize the impact of
disease and reduce the cost of medical care.

The Institute along with the Lubbock Senior Center will
be hosting Fit for Life Texercise classes once a month.
These classes will help promote healthy muscles, bones
and joints, improve balance and coordination, increase
stamina, and teach seniors the correct way to exercise
without injury.

At the Grab the Challenge: Fit for Life kickoff in Novem-
ber 2010, over 50 people registered to participate in the
Texercise program. Guests were able to listen to expert
speakers emphasize the importance of exercise and nu-
trition on brain health, as well as, participate in interac-
tive exercise demonstrations courtesy of UMC Activities
Center.

21

Healthy Lubbock Day Amazing Race made health and fitness fun

Over 500 people battled the heat and attended the sixth glucose and body fat percentage provided by the TTUH-
annual Healthy Lubbock Day on June 5 at Maxey Park. SC School of Nursing, Texas Tech Physicians, Bodyworks,
The free three-hour event was hosted by the Healthy UMC, and Covenant Lifestyle Centre.
Lubbock Initiative, a program of the Garrison Institute
on Aging, in collaboration with the City of Lubbock Parks The City of Lubbock Mayor Tom Martin made a special
and Recreation and Bodyworks Family Sports Center. appearance to proclaim June 5, 2010 as Healthy Lubbock
This program seeks to make Lubbock, and surrounding Heart and Stroke Day to raise awareness of preventative
communities, a healthier place by supporting and moti- health. Participants were also able to gather information
vating people to become active through physical activity on living a healthier lifestyle from over 60 vendors that
and improved nutrition. were on hand.

New to the event this year was the Healthy Lubbock Day Above: Healthy Lubbock committee member, Anissa Johnson and Lubbock
Amazing Race obstacle course, in which twenty teams Mayor Tom Martin proclaims June 5, 2010 Healthy Lubbock Heart and
consisting of family and friends competed against each Stroke Day. Right: Participants take part in an outdoor Zumba class at
other in a battle of fitness and wits. The race consisted Healthy Lubbock Day.
of events like playing tennis, paddle boating, and Fris-
bee golf which took most participants over 20 minutes
to complete. Bodyworks’ Monster City, complete with a
spider climb and climbing wall, was available to all par-
ticipants. Prizes, paddle boats, a bike rodeo, as well as a
series of demonstrations such as Tai Chi, Pilates, Zumba
and self defense were also a part of the festivities.

Attendees had the opportunity to take part in free health
screenings including; cholesterol, blood pressure, blood

22

23

Trailblazers

Trailblazer Committee Mission

To develop the Garrison Institute of Aging’s image and stature by disseminating information about the Institute’s

programs and initiatives and securing funding for advanced research, education and community outreach efforts.

Carroll Akard 2010 Committee Carolyn Sowell
Carole Collier Russ Stratton
Rebecca Gonzales Sally Murray Sandy Stratton
Susie Hance Jane Nagy Jane Strong
Deann Lechtenberger Liesl Olsen Cliff Wilkes

Raquel Quigley

24

Friends of the Institute

Maria Arroyo Corporate & Organizational Sponsors
Jack and Shirley Barnes
Thomas Bartlett Accolade Homecare Humana Marketpoint
Rebecca Berryhill Betenbough Homes LakeRidge Country Club
Sally Carlson Bodyworks Family Sports Center Lubbock Parks and Recreation
William Crouse Calvert Home Health Care Premier Sportsplex
Linda and Kirby Culp Chick-fil-A Raider Ranch
Bobby and Delmarie Davis Community Health Center Texas Department of State Health
Shirley and LuCille Garrison
Patsy and David Goolsby of Lubbock Services
Kimberli Harrison Compass Equity Partners LLC Texas Tech Physicians of Lubbock
Ransom Horne Copy Craft Printers Texas Tech Rec Sports
Kathryn Kalinowski Covenant Health System The CH Foundation
Jason and Kende Jessup Curves TTU Men’s and Women’s Basketball
Susan Linscott Falls Tennis and Athletic Club TTU Office of the Chancellor
Rocille and James McClain First Care Health Plans The Shropshire Agency
Trish Rylee FIT Tech TTUHSC Anita Thigpen Perry
Dee Ann Salehi Foot Tech
Carolyn Sowell Garrison Family Foundation School of Nursing
Anthony and Jan Stanford Garrison Geriatric Education and UMC Activities Center
Dustin Stiefel UMC Health System
Jeff and Lynn Thompson Care Center United Supermarkets
Randy and Mary Whitsitt Hub City Aviation YWCA
Rosemary Wilkerson
David and Marihelen Willis

25

Financial Overview

As the 10 million baby boomers in the United States continue to age, the importance of finding better treatments
for neurodegenerative diseases becomes increasingly significant. Institute researchers have been successful in
attracting competitively awarded grants from the National Institutes of Health which account for 40% of the
annual budget. Approximately 35% of Institute support is comprised of non-federal funding and 25% is funded
by private foundations and individual donors.

Funding Sources FY 2010

Federal 835,835
Non-Federal 730,813
Endowment Earnings + Private Donations 517,059

Total Revenue 2,083,707

Federal - 40%

Endowment Earnings +
Private Donations - 25%

Non-Federal - 35%

26

Faculty and Staff

Charlotte Bass Paula Grammas, Ph.D. Sid O’Bryant, Ph.D.
Assistant Director Executive Director Director of Rural Research
Finance & Administration Professor of Neurology F. Marie Hall Institute for Rural and
Annette Nichols Boles, MS Mildred and Shirley Garrison Community Health
Assistant Director Chair in Aging Assistant Professor
Education and Outreach Director, Alzheimer’s DNA Department of Neurology
Research Bank Director of Geriatric Community
Outreach
Diane Botello, RN Janice Hicks Akhilesh Pandey, Ph.D.
CNA Nurse Educator and Assistant Director Post Doctoral Research Associate
Training Program Coordinator Finance & Administration Alma Sanchez, Ph.D.
Post Doctoral Research Assistant
Jessica Bowley, RN, BSN Manasa Rao Kohirker Deniese Smith
CNA and LVN Nurse Educator Medical Research Technician Unit Coordinator
Terri Stahl
Tori Como Jason LeMaster Research Manager
Medical Research Technician Marketing Coordinator Debjani Tripathy, Ph.D.
Post Doctoral Research Associate
Amy Crumley, M.B.A. Katie Liston, MA Xingjia Wang, Ph.D.
Assistant Director Unit Coordinator Assistant Professor Neuropsychiatry
Marketing Kristi Louder and Director of Scientific Development
Andrew Dentino, MD, FACP, Coordinator Janet Woolam
AGSF, FAPA, CMD Ester Luo, Ph.D. Brain Bank Coordinator
Director Post Doctoral Research Associate Lauren Wyshywaniuk
Clinical Geriatrics Medical Research Technician
Linda Yin
Katie Desobry Mark Lyte, Ph.D. Medical Tech III
Student Assistant Professor of Pharmacy Practice Department of Neurology
Jason Fields Director
Student Assistant Translational Research 27
Department of Neurology Joseph Martinez
Ruben Gonzales Assistant Director
Sr. Director Brad Miller, M.D., Ph.D.
Alzheimer’s DNA Bank and The CH Foundation Regents Chair
GIA Research in Parkinson’s Disease Research
Department of Neurology, Associate Executive Director
Brain Bank Assistant Professor
Department of Pathology

Publications Duff, K, Spering, CC, O’Bryant, SE, Beglinger, LJ, Moser, DJ, Bayless, JD,
Culp, K, Mold, JW, Adams, RL, & Scott, JG. The RBANS effort index: Base
Pandey A, Yin X, Stocco D, Grammas P, Wang X. Blocking L-type calcium rates in geriatric samples. Applied Neuropsychology, In Press.
channels reduced the threshold of cyclic AMP-induced steroidogenic acute Humphreys Clark, J, Hobson, VL, & O’Bryant, SE. Diagnostic accuracy of
regulatory gene expression in MA-10 mouse Leydig cells. Journal of Endo- percent retention scores on RBANS verbal memory subtests for the diag-
crinology, 204:67-74, 2010 nosis of Alzheimer’s disease and Mild Cognitive Impairment. Archives of
Tripathy D, Thirumangalakudi l, and Grammas, P. RANTES upregulation Clinical Neuropsychology, In Press.
in the Alzheimer’s disease brain: a possible neuroprotective role. Neurobi- O’Bryant, SE, Richardson, D, Perez, C, Nevarez, L, Rice, J, Wilbanks, L,
ology of Aging 31: 8-16, 2010. & Hobson, V. Physical activity is associated with cognitive and affective
Yin X, Wright J, Wall T, Grammas P. Brain endothelial cells synthesis neu- status among rural-dwelling Texans: A Project FRONTIER study. Texas
rotoxic thrombin in Alzheimer’s disease. American Journal of Pathology, Public Health Journal, In Press.
176:1600-6, 2010. O’Bryant, SE. Hall, JR, Cukrowizc, K, Edwards, M, Johnson, LA, Lefforge,
Tomashevski A, Webster DR, Grammas P, Kruman II. Cyclin –C-dependent D, Jenkins, M, & Dentino, A. The differential impact of depressive symp-
cell-cycle entry is required for activation of non-homologous end joining tom clusters on cognition in a rural multi-ethnic cohort: A Project FRON-
DNA repair in postmitotic neurons. Cell Death Differentiation, 17:1189- TIER Study. International Journal of Geriatric Psychiatry, In Press.
98, 2010. Johnson, LA, Hobson, V, Jenkins, M, Dentino, A, Ragain, M, & O’Bryant,
Li W, Pandey A, Yin X, Chen J, Stocco D, Grammas, P. Effects of Apigenin SE. The influence of thyroid function on cognition in a sample of ethni-
on steriodogenesis and steroidogenic acute regulatory gene expression cally diverse, rural-dwelling women: A Project FRONTIER Study. Journal
in leydif cells.Journal of Nutritional Biochemistry, 2010, [Epub ahead of of Neuropsychiatry and Clinical Neurosciences. In Press.
print]. Wiechmann, AR, Hall, JR, & O’Bryant, SE. The utility of spatial span in
Sanchez A, Wadhani S, Grammas, P. Multiple neurotrophic effects of a clinical geriatric population. Aging, Neuropsychology, and Cognition,
VEGF on cultured neurons. Neuroscience Research, 44:323-331,2010. 18(1): 56-63, 2010.
Luo J, Grammas P. Endothelin-1 is elevated in Alzheimer’s disease brain O’Bryant, SE, Hobson, VL, Hall, JR, Barber, RC, Zhang, S, Johnson, LA, Di-
microvessels and in neuroprotective.Journal of Alzheimer’s Disease, az-Arrastia, R. Serum brain-derived neurotrophic factor (BDNF) levels are
21:887-96, 2010. specifically associated with memory performance among Alzheimer’s dis-
Evola M, Hall A, Wall T, Young A, Grammas, P. Oxidative stress impairs ease cases. Dementia and Geriatric Cognitive Disorders, 31: 31-36, 2010.
learning and memory in apoE knockout mice. Pharmacology Biochemis- Duff, K, Hobson, V, Beglinger, LJ, & O’Bryant, SE. Diagnostic accuracy of
try Behavior, 96:181-6, 2010. the RBANS in Mild Cognitive Impairment: Limitations on assessing mild-
Tripathy D, Yin X, Sanchez A, Luo J, Martinez J, Grammas P. Cerebrovas- er impairments. Archives of Clinical Neuropsychology, 25(5): 429-441,
cular expression of proteins related to inflammation, oxidativestress and 2010.
neurotoxicity is altered with aging. Journal of Neuroinflammation, 2010, O’Bryant, SE, Falkowski, J, Hobson, V, Johnson, L, Hall, J, Schrimsher,
(Epub ahead of print). GW, Win, O, Ngo, B, & Dentino. Executive functioning mediates the link
Grammas P. Angiogenic mediators and the pathogenesis of Alzheimer’s between other neuropsychological domains and daily functioning: A
disease. In Therapeutic Angiogenesis for Vascular Diseases. Slevin, M, ed, Project FRONTIER Study. International Psychogeriatrics, online ahead of
Springer, 2010, In Press. print, 2010.
Grammas, P, Sanchez A, Tripathy D, Luo J, Martinez J. Vascular signaling Gong, G. & O’Bryant, SE. The arsenic exposure hypothesis for Alzheimer’s
abnormalities in Alzheimer’s disease. Cleveland Clinic Journal of Medi- disease. Alzheimer’s Disease and Associated Disorders, online ahead of
cine, 2010, In Press. print, 2010.
Johnson, LA, Jenkins, M, Mauer, C, Hall, JR, & O’Bryant, SE. The relation
between Vitamin D and depression in a rural dwelling sample: A Project
FRONTIER Study. Texas Public Health Journal, In Press.

28

O’Bryant, SE, Xiao, G, Barber, R, Reisch, J, Doody, R, Fairchild, T, Adams, Bailey, M.T., Dowd, S.E., Parry, N.M., Galley, J.D., Schauer, D.B., Lyte,
P, Waring, S, & Diaz-Arrastia, R. for the Texas Alzheimer’s Research Con- M. Stressor exposure disrupts commensal microbial populations in the
sortium. A serum protein-based algorithm for the detection of Alzheimer’s intestines and leads to increased colonization by Citrobacter rodentium.
disease. Archives of Neurology, 67(9): 1077-1081, 2010. Infection and Immunity, 78:1509-1519, 2010.
Hobson, VL, Hall, JR, Harvey, M, Cullum, CM, Lacritz, L, Massman, PJ, Lyte, M. Microbial endocrinology as a basis for improved L-DOPA bioavail-
Waring, SC, & O’Bryant, SE. An examination of the Boston Naming Test: ability in Parkinson’s patients treated for Helicobacter pylori. Medical
Calculation of an ‘estimated’ 60-item score from 30- and 15-item scores in Hypotheses, 74:895-897, 2010.
a cognitively impaired population. International Journal of geriatric Psy- Pullinger, G.D., Carnell, S.C., Sharaff, F.F., van Diemen, P.M., Dziva, F,
chiatry, 25(5): 525-530, 2010. Morgan, E, Lyte, M, Freestone, P.P., Stevens, M.P. Norepinephrine aug-
O’Bryant, SE, Lacritz, L, Hall, J, Waring, S, Chan, W, Khodr, ZG, Mass- ments Salmonella enterica-induced enteritis in a manner associated with
man, P.J, Hobson, V, & Cullum, CM. Validation of the New Interpretive increased net replication but independent of the putative adrenergic sen-
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