A3.2- Leprosy drugs

rifampin, rifabutin, ethambutol, clofazimine: For a few mycobacteria more

1. Caged mockingbird: mycobacterium avium complex (MAC) (Mycobacterium avium, Mycobacterium intracellulare) Intracellular
as in inside macrophage

2. Crows: a macrolide (e.g. azithromycin or clarithromycin) combined with ethambutol treat MAC infections
3. Sheriff ethel: ethambutol
4. Immunocompromised cane: MAC is a common cause of disseminated disease in AIDS patients
5. Macrolide prophylaxis for MAC when CD4<50
6. Prophylaxis treatment with macrolides - azithromycin and clarithromycin
7. Buttes: rifabutin (may be added as a third agent in treatment of MAC infection)
8. Rifle: rifampin (related to rifabutin)
9. Speeding chrome bumper: rifampin and rifabutin activate cytochrome P450
10. Driver is halting horse: rifabutin is less potent than rifampin in activating P450; used in AIDS patient under antiviral treatment
11. Leaping armadillo: Mycobacterium leprae (acid fast stain); armadillo is animal reservoir of leprosy; Rifampin added for long-

term treatment
12. Deputy zone: dapsone with 2 side effect
13. Multi-lobed sand timer: agranulocytosis
14. Hemolytic anemia broken G6PD-free fruit: hemolytic anemia in G6PD deficiency
15. Bite and seeds: bite cells and Heinz bodies seen in RBCs
16. Cloth: clofazimine treats Lepromatous leprosy
17. Lion bandana: leonine facies seen in Lepromatous leprosy
18. Rifle: rifampin treats leprosy caused by Mycobacterium leprae