HealthSpectra Magazine-May2019

Relationships are just like the pearls stringing Love, respect, care and be there for each
on a thread, a blow can either break it or other so much that the two of you fall in love
make it stronger. If you have found each with each other every single day and know
other and for a fact that the two of you make how to fight a 100 times and find one reason
each other feel great and special then the to stay together. To help couples get better
two of you should make an effort to grow ideas, here are ways to understand how you
old in this relationship by not just ‘staying’ in can be happy in a relationship and not just
the relationship but by being ‘happy’ in that be there in a relationship.
relationship.

Forget The Bitter Moments
To Make Sweeter One’s

When two like-minded or unlike-minded
people are closed together, chances are
that they will survive it well and there can be
situations wherein they would fight to the
core. Moments of difference in opinion and
clashes will be a part of the journey.

When you are in a relationship, always
remember that everything is not going to
be perfect, the two of you have to keep in
mind that both of you will not be able to get
along each and every-time, if you want to
be together you must learn to leave behind
what happened yesterday by confronting
each other and step into a new day with the
same love.

Make Transparency The
Bible Of Your Relationship

It is said that sometimes it is not necessary to it. In rare cases, it is okay to hide. As making
say everything to each other because it can love is not the only element in a relationship,
form a crack in the relationship. But would in order to build faith and make it strong the
you be able to answer to your conscience two of you must be like mirrors to each other
if you do that? and isn’t it disrespecting the in terms of letting each other know about the
relationship? Keep this in mind. worst to the best things happening in your
life. When transparency becomes the base
It is okay to hide from your partner when you of your relationship, no trust issues can ever
know that the person at any cost cannot take cause disappointment in your love life.

51 WWW.HEALTHSPECTRA.COM | MAY 2019

LOVE & SEX Do Not Miss On The
Little Things
WWW.HEALTHSPECTRA.COM | MAY 2019
It is true that the little things in
a relationship can leave behind a
happy imprint in your mind and
heart. Having said, even if you are
old in the relationship it is never
too late to do the little things
that can keep the flame in your
relationship glowing forever.

There are several sweet and
romantic ways of expressing love
to each other, start with giving a
big smile and a hug to each other
every day, give each other little
surprises like leave behind small
love notes for each other, play an
outdoor or indoor game together,
cook each other’s favorite dish,
surprise each other by wearing
colors that your partner likes,
etc. Every day the two of you will
be happy in the relationship with
all the little things.

To collect all thoughts on how to
be happy in a relationship and
conclude it all, it is essential that
the two of you do not take each
other for granted just because
you know that the two of you are
anyways there for each other.
That’s not how a relationship
should be taken ahead. Do not
just be in a relationship but see
to it that your efforts for each
other make a happy relationship.

52

Stay Out Of Each Others Love Each Other From The
Personal Space Inside Out

We all have a life of our own besides the circle Yes, you would love each other for the
of relationships we maintain. Even though internal and external beauty you both have.
you have the best of friends and you are No doubt! But if you want to be happy with
extremely close to all your family members, each other you have to go deeper and love
still there is a person in you who wants to be each other despite the flaws.
to herself or himself, that’s nothing but the
need for personal space. If you truly want to be happy in a relationship,
you have to accept each other’s flaws
It is difficult when you are too close to with just one thought in mind that you are
someone to understand when to give each not perfect either. It is essential to have a
other that personal space, but it is necessary motivating factor in life and that can come
that you both know where to draw the line from appreciating each other for the good
in terms of giving each other personal space. you’ll do. Appreciation and acceptance must
When you respect each other’s personal be there in a relationship to keep each other
space and trust each other blindly you just happy.
won’t realize how the magical happiness
between the two of you would just grow in
time.

To fall in love is easy and
to fall out of love can also
be easy if a couple is not
happy in the relationship.
Keep your man and
woman with you forever
by giving them all the
love and importance they
deserve!

53 WWW.HEALTHSPECTRA.COM | MAY 2019

MEN HEALTH

ITTsosMouoPeeasnCsTsoHhmUeaapmtltAOohnrne

WWW.HEALTHSPECTRA.COM | MAY 2019 54

SEXUALLY on the history as well as the to be the number one reason
TRANSMITTED kind of lifestyle one is leading, behind the deteriorating
DISEASES men are often at a heightened condition even more so. It is
risk of a number of cancers. important for men to have
Not many people realize this Younger men have been a regular screening for their
but the phase of 20s is often reported to have heightened cholesterol levels from time to
one of the riskiest times for risks of skin cancer. This is time to ensure that you don’t
one of those factors that is suffer from any downsides all
not often assessed and seen the more.
around during majority of
the wellness examinations. ERECTILE
In later stages of life, risks of DYSFUNCTION
prostate and colon cancer are
heightened as well.

CARDIOVASCULAR
DISEASE

men to contract sexually If the statistics of the American Erectile dysfunction in men
transmitted infections or Heart Association are to be is more common than
diseases. The same is often considered, they believe that you think. Majority of the
at a heightened pace if they scientists believe that the
have multiple sexual partners. at least 1 in 3 men suffer from condition is mainly prevalent
The human papillomavirus, some form of cardiovascular when the patient suffers from
or HPV, is the most common disease. This is thus often two chronic diseases at once.
one of the all and do have considered as the most Diseases like diabetes and
the capability of ending up common men health issue. hypertension together can
causing issues with their Lack of healthy eating habits often end up being the reason
health, even leading cancers. and lifestyle has been devoted behind the same all the more.
One of the best ways to It is completely futile to try to
protect yourself from this self treat the problem because
is by opting for preventive that is not accessible. Talking
measures using condoms. to a professional can provide

CANCER

The risks of cancer are very
profound in men, irrespective
of contrary beliefs. Depending

55 WWW.HEALTHSPECTRA.COM | MAY 2019

MEN HEALTH

with a better perspective and often even underdiagnosed constant rise. Psychologists
outlook on the same. in some of the young men. believe that men are often
People suffering from this the most underdiagnosed
DIABETES condition have a rough and population, especially when
hard time in concentrating it comes down to anxiety and
Owing to the fact that men and staying focused through depression.
tend to leave their homes the process. Disorganization,
and start their career in their forgetfulness as well as trouble COPD AND
managing the emotions are RESPIRATORY
often regarded as some of DISEASES
the symptoms. It is important
to see necessary help to fight Chronic obstructive
through it without any further
negative issues. pulmonary disorders and just

DEPRESSION respiratory diseases in general

Mental health issues,
especially depression, aren’t
technically bound to one

20s, the sudden change and gender type. If the statistics are quite common in men.
crossover in their lifestyle as are to be considered, over 6 Owing to the fact that men are
well as diet has been found million people in the United more subjected to smoking
to be the contributing factor States itself suffer and and tobacco products more
to the induction of diabetes struggle with depression. than what women would, the
in men. Obese men are at a Owing to the fact that men same does end up affecting
heightened risk of developing are often discourages to the life expectancy of such
diabetes because the weight talk about such issues, the individuals too. This increases
gain has been correlated rate of growth of this is on a and heightens the risks
with the insulin resistance associated with lung diseases
and such which does end up as well.
making the situation worse.

ADHD

Also known as Attention-
deficit hyperactive disorder,
ADHD is a lot common in men
that what you would think of
it as. It is very common and

WWW.HEALTHSPECTRA.COM | MAY 2019 56

HEALTH TIPS

1 EATING NUTS 4 CONSUMING
CAN HELP YOGURT
YOU LOSE
WEIGHT CAN HELP
IMPROVE GUT

HEALTH

2 HTeipalsth 5

COFFEE TAKE VITAMIN
DRINKERS D3 IF YOU
HAVE BEEN DON’T GET
FOUND TO
LIVE LONGER MUCH SUN

3 CONSUMING ADD IN EXTRA
OVERCOOKED OR
BURNT MEAT CAN 6 VIRGIN OLIVE
INCREASE RISKS OF OIL IN THE
CANCER DAILY DIET

57 WWW.HEALTHSPECTRA.COM | MAY 2019

HEALTHY RECIPIE

Butter
Milk Soup
With Dill
And Peas

Introduction to the your body. Dill is amazing as it helps
recipe of a healthy your body fight against unwanted
soup : infections and it is a healthy source of
fiber, folate, calcium, iron, manganese,
Soups are the best when you do not and iron.
want to have a heavy meal and at the
same time, you want to be healthy by Talking of peas, it cures all the
eating something nutritious and light. indigestion problems and keeps a
Green soups denote good health, check on the blood sugar levels in
isn’t that a common psychology we all your body. Apart from this, it has rich
have? Right? nutrients and antioxidants.

Buttermilk soup with dill and peas All in all, this soup is high in fiber, low in
blooms your system by keeping it cool carbohydrates and fats. Wow! Sounds
and provides effective nutrients to healthy and seems scrumptious. Here
is how you make this soup!
WWW.HEALTHSPECTRA.COM | MAY 2019
58

Advantages of The Ingredients You Will
Drinking This Soup Need

All the accumulated heat and 1/2 a cup chicken broth
toxins in your body would get
flushed out because of the 2 cups peeled peas
buttermilk
Spinach - 1 cup
Peas and Dill are green
vegetables that will add up to Dill - 1 Tbsp
the nutrients in your body
Salt - 1/4th Tsp
Drinking soup is easier
because it seems light. On the Pepper - 1/8th Tsp
other hand, it helps in keeping
59you full for longer. Buttermilk - 1/2 a cup

Butter - 1 Tsp

1 piece of broccoli

Steps To Make This Soup

STEP 1

Take a pan and add peas,
spinach, and dill. Stir and saute
these vegetables in butter, add
salt and pepper while sauteing.
Saute all of these for about 8
minutes,
STEP 2

You have the vegetables
sauteed, let them cool down
so that you can go ahead and
blend them well. Take a blender,
add these vegetables with a
little water and make it a paste.

STEP 3
You have the paste ready as
well. Now add buttermilk to this
paste and stir it well.

The soup is ready,
WWW.HEALTHSPECTRA.COM | MAY 2019

YOGA

Discover Your New Self With

(TTrriiaknognlaesPaonsae)

An asana that helps in increasing your strength,
flexibility, and balance

WWW.HEALTHSPECTRA.COM | MAY 2019 60

TMreikaonninagsaonfa USpnirdietrusatlanding
Of Trikonasana
Sanskrit Meaning
Just as Trikonasana is a three-angled asana,
1. Utthita -’extended’ it can be related to a spiritual meaning
2. Tri - ‘Three’ which means the presence and power of
3. Kona - ‘Angle’ the Almighty. Have you heard of the term
4. Asana - ‘Posture’ Trimurti? As per Hinduism, it means the
presence of Brahma, Vishnu and Shiva and
Trikonasana is also known as Uttiha each of these forms take care of the universe.
Trikonasana. It is classified in two Baddha
Trikonasana and Parivrtta Trikonasana. Lord Brahma - The creator
This asana has about 5 sequences while w Lord Vishnu - The Preserver
performed and some of those variations are Lord Shiva - The destroyer
bound triangle pose, bound revolved triangle
pose, revolved triangle pose and reclining The teen murtis are responsible to keep a
triangle pose. balance in the universe. Likewise, trikonasana
takes care of our body and keeps the mind
This asana focuses on both the upper an lower and body stabilized and balanced.
body equally. Keeps the groin, shoulders,
hips, lower back, thighs, knees, ankles, and All in all, the manifestation of Trikonasana
chest strong. It is considered to be one of the can be co-related to our health and well
best exercises for pregnant women as well. being. The number three has its immense
power all around.
TCroi-kroenlaatsiaonnaOf

There is a co-relation of Trikonasana from
the ancient times and it has been there in
the scriptures as Egyptian pyramids and the
significance of three is there in mythology
and religion having the significance of power
and divinity.

In other words, this triangle pose represents
stability, grace and a good posture of your
body. This asana eases your mind, body, and
spirit. In fact, every asana does.

61 WWW.HEALTHSPECTRA.COM | MAY 2019

YOGA

TStreikposnTaosDanoa left bringing your left hand down holding
your leg and lift your right hand up pointing
Keep these points in mind before the sky.
beginning :
STEP 4
Before you begin this asana keep in Exhaling bring our body up and keep your
mind to eat your food at least three legs and hands stretched. Let your hands be
hours before you begin and take perpendicular to your shoulder.
maximum benefit of this asana by
doing it as slow as you can STEP 5
Start to inhale and slowly bend towards your
Ensure to do few other asanas before right bringing your right hand down holding
you go on for this asana to help you your right leg and lift your left hand up
successfully complete Trikonasana. pointing the sky.
Few of those asanas are Vrikshasana,
Konasana, and Katichakrasana Note :

Under few circumstances such as You have to look up at your hands when you
having high or low blood pressure raise them high pointing at the sky
and those with pain in their back must
avoid doing this asana. Although this Stay in this position for about a minute on
asana is good for pregnant women, both sides and do this asana as slow as
one must consult a doctor and do it you can by inhaling when you go down and
under the guidance of a well-trained exhaling as you come up
instructor
Stretch on both the sides at least twice
The best time to perform this asana is
early in the morning This asana will help you stretch well on either
side. Starting from your head to toe you will
be stretching

STEP 1 62
Look straight in the front and stretch your
legs as much as the width of your shoulders.

STEP 2
Stretch your right foot a little more and
breathe in by raising both your hands until
your shoulders

STEP 3
Start to inhale and slowly bend towards your

WWW.HEALTHSPECTRA.COM | MAY 2019

PArsoan’saOf This thighs and waist just goes down drastically.
Keep doing this asana at least 3-4 times a
Functions Better Blood Flow week to see the difference.

The movement of blood passing through your Aids Better Digestion
entire body gets better and remains good.
The only reason this happens is that you are Trikonasana cures all your indigestion and
stretching yourself in the entire asana. this happens because the stretches of this
asana improve and keeps a good balance in
your intestines. By chance, if you have any
bloating issues it all goes away when you do
Trikonasana.

Boosts Strength Mind Remains Stable

It is said that stretching improves flexibility Stretching not only makes your body flexible
and when your body gets flexible it is and strong but it also releases hormones to
automatic for the strength in the hips, back, keep your mind balanced and stable. That
thighs, arms and legs to increase. Your overall stability and peace of mind comes because
body strength is taken care of in this asana the process of stretching involves focusing
your mind on physical activity.
Stress Disappears
Kidneys Function Better
This asana is one of the best to help you bring
down your stress levels. The cortisol hormone The kidneys in our body are responsible to
that is responsible for stress is not released take out all the wastes from the urine and
much whereas the endorphins hormone that ensure the smooth flow of blood in the body.
is responsible to make your mood better Being used to exercising regularly helps the
increases and all your stress just disappear. kidney do their task well.

No More Anxiety And Blood Having said, as per National Kidney Function
Pressure Issues by exercising one gets the benefit of a
balance in the blood pressure, better sleep,
As trikonasana is all got to do with stretching the cholesterol is in check and the kidneys
it is suggested by a study that stretching are less likely to get affected.
makes your arteries flexible and that helps in
keeping your blood pressure in control. It is a Do Trikonasana
fact that exercising for at least 30 minutes a and reap
day brings down all our anxiety. its mental

Cuts Down On Fats and physical
benefits on
As the asana focuses on stretching on your your body!
sides all the fat that is accumulated on your

63 WWW.HEALTHSPECTRA.COM | MAY 2019

HOME & FAMILY

Ways To 64
Protect
Your Family

From

Toxic
Molds

WWW.HEALTHSPECTRA.COM | MAY 2019

Harmful Molds In Our Homes And
Impacting Our Families Health

Usually, if a place lacks not life-threatening but after It is always better to prevent
ventilation and there is too a while, it all changed and it and stay away from it
much-suffocating moisture leads to people having bad
and humidity it gives rise to allergic reactions. This allergic Based on another study, a
toxic molds. We must prevent reaction happens because person who is already having
these molds in our home there are mycotoxins present health issues such as asthma,
and do all that it takes to in them that cause fungal other allergies, and a weak
never allow it to get back in infection. immune system is sure to
our homes to ruin our family get affected after inhaling
members health. In one of the reports these toxic molds. It is even
prepared by United States life taking if the exposure to
Molds are omnipresent in Centers For Disease Control these molds is for a longer
the atmosphere and they And Prevention, it was said period of time. They are not
are commonly found in the that the mold spores are just harmful to human but
dust at home and at the dangerous if they are too they can affect animals as
workplace. Earlier it was said much in quantity and they can well.
that these toxic molds are cause harmful diseases too.

Identify Molds At Home

When you see that there is
some kind of fungus in the
form of minute particles
seeped into the walls of your
home it is time to work on the
walls and have them removed
immediately as you want to
avoid respiratory issues and
other allergies from hitting on
your health.

65 WWW.HEALTHSPECTRA.COM | MAY 2019

HOME & FAMILY

There are different names to these toxic molds
and let’s look at each of them one by one.

1 . CLADOSPORIUM MOLD at home or in one of the parts carpets, this fungus is velvety
of your air conditioner. This and it should be treated to
Usually, you will find this toxic triggers if there is too much avoid respiratory concerns
mold indoors when walls are humidity at home. It can have for the family members.
getting painted, although bad effects on kids, elders
it is not toxic and is not life- and those with low resistance 4. PENICILLIUM MOLD
threatening at the max it power. You would certainly
would affect you with allergy have allergic reactions with Penicillium is a known toxic
if you are sensitive. To be able this mold. mold that settles on spoilt
to identify it, it is a black or food. If eaten, it can cause
green colored fungus. 3. ALTERNARIA MOLD indigestion and lead to other
food allergies. The only way
2. ASPERGILLUS MOLD Alternaria loves to be in the to stay away from Penicillium
air and not in moist places. It is to just throw away the spoilt
This mold is usually seen in commonly sticks to rugs and food.
cases when there is a leakage

Measures To Take To Remove ‘Toxic Molds’

Toxic molds can either best for you. If you manually risking your health.
be removed manually or go ahead to clean it then
someone can be hired to you will undoubtedly save Apart from just risking your
get them removed. You can money but it is not a doddle health, at times the mold
go for the option that works either because you are in turn spores won’t be at your

WWW.HEALTHSPECTRA.COM | MAY 2019 66

reach they would be in the late and your family faces the Ensure to use a mask during
extreme ends of the wall and risk of inhaling the bad mold this entire process.
you would not be able to spores. To get to the right person who
single-handedly clean it up can help remove the mold
with the mold chemicals and To be on a safe side, ensure get in touch with the mold
solutions, it is better to have a to check on the spores on inspection department and
professional come and work your walls as well as on the get the walls and furniture
on it before it becomes too other furniture in your home. cleaned.

Here is what you can do to keep away from the molds

Inspect all the water pipes in your home and see to it that even if there is a damage
in the pipe you take immediate steps o repair it.

As soon as you see a green or black spot on the walls of your home, immediately call
the mold inspection team.

Get a dehumidifier installed if you think you need one for your home to keep away
all the unwanted moisture.

For sufficient ventilation all around your home, you have to get used to keeping
your windows open once a day for a while and see to it that you have fans and air
conditioner in your home so that there is proper air circulation all around your home.

If the molds are not too much and they can be cleaned up yourself all you have to
do is find mold cleaning products at a hardware store, use detergents that do not
have ammonia in them such as borax, baking soda, tea tree oil, bleach, and hydrogen
peroxide. These products would not cost a bomb from your pocket and if they are
minor molds then why not do it yourself.

Some places such as the base of your sink or the cutting boards that go unnoticed
and you may not be used to cleaning them well that finally leads to mold spores.
Ensure to keep these areas clean with vinegar or baking soda.

Be aware of the clothes that you use to clean your dishes and the carpets at home,
there could be molds in them as well. The best way to keep them clean is by using
baking soda.

Therefore, do not take toxic molds as a joke and ignore them. Ensure to keep your home ventilated
and not suffocated with unwanted dampness. As and when you notice there is fungus forming
on your wall, furniture or clothes with immediate effect work on it and take good care of every
member in the family by saving them from this problem.

67 WWW.HEALTHSPECTRA.COM | MAY 2019

HEALTHY LIVING

Quality
Sleep

Is Capable Of Cleaning
Toxins Off Your Brain

Sleep is crucial for our overall wellbeing. It goes without saying
that lack of sleep of even people suffering from insomnia tend
to have labored well being and an overall affected life. The
quality of sleep you have does have impacts on your brain’s
cleaning process, if you didn’t know it.

WWW.HEALTHSPECTRA.COM | MAY 2019 68

A new study conducted by the researchers its impacts on the brain detoxification and
from the University of Rochester Medical waste removal was first established in 2012
Centre showcased how one’s depth of sleep by Nedergaard and her colleagues. In the
has the capability of efficiently cleaning away study, the team of researchers found that
the harmful toxic proteins and waste out of the brain, which had its separate ecosystem,
the brain. did have a system of plumbing which uses
blood vessels and does pump cerebro spinal
Owing to the fact that sleep does come in fluid through the brain to wash away the
spurts and a lot disrupted with age, the study waste and toxins. They also subsequently
also emphasized and extensively explained found that the entire system was primarily
the links between the lack of sleep with aging, active when we were asleep.
sleep deprivation and even the heightened
risks of Alzheimer’s disease. In the recently conducted study, the
researchers did conduct the experiments on
Maiken Nedergaard, M.D., the mice, administering them six different
D.M.Sc., co-director of the Center anesthesia regimens. While the mice were
for Translational Neuromedicine under anesthesia, the researchers analysed
the brain electrical activity, cardiovascular
at the University of Rochester activity as well as the cleansing flow of the
Medical Center (URMC) who CSF through the brain.
is also the lead author of the
study stated the sleep is a very On their further analyses, they found that it
important factor when it comes was the combination of the drugs, ketamine
to the function of the waste and xylazine which was found to replicate
removal from the brain and the the slow and steady electrical activity in the
conducted study successfully brain along with the slower heart rate which
shows that the better the sleep, is characteristic of the non-REM sleep.
the better is the detoxification.
They also found that the impacts of this drug
He further added that this also does explain
how sleep and sleep deprivation can have
impacts on the early onset of the age related
diseases like Alzheimer’s and Dementia.

In this study, the researchers have successfully
established the fact that it is the slow and
steady cardiopulmonary activity during the
non-REM sleep which has important impacts
on the overall functioning of the glymphatic
system which is responsible for removing
waste from the brain. This study was
explanatory of why some form of anesthesia
does lead to some cognitive impairment in
the brain.

The presence of the glymphatic system and

69 WWW.HEALTHSPECTRA.COM | MAY 2019

HEALTHY LIVING

combination did have the optimal benefits emphasise on the same functions as we
on the glymphatic system in the brain. age. Given the fact that it becomes harder
to achieve better quality of non-REM sleep
Lauren Hablitz, Ph.D., a as we age, it was possible that the same
postdoctoral associate in could be indicative of the heightened risks of
Nedergaard’s lab who is also the Alzheimer’s and Dementia.
first author of the study stated
that the synchronized waves It is believed that this study could provide with
during the neural activity in the better perspective into understanding and
brain during sleep especially coming up with better clinical approaches
that of the deep-slow wave sleep encircling the same, like that of sleep therapy
along with the firing patterns is for the population at risk.
what did end up coinciding with
the CSF flow in the glymphatic Apart from all of this, the researchers also did
find negative impacts of the anesthesia on
system. the brain activity and the glymphatic system
activity in the mice. This problem was found
Hablitz further stated saying that the to be more in the elderly patients who are
chemicals which are involved in the firing of subjected to such anesthesia for a surgery
the neurons, the ions, to be more specific, and such.
conduct a process of osmosis which is what
is responsible in pulling the fluid through the Wrapping everything up, deep sleep is
brain tissue altogether. associated with potent brain functions and
detoxification with the aid of the glymphatic
The study, apart from the common grounds system. The better the sleep, the better is the
of finding the impacts of sleep on the brain getting rid of the toxins and waste out of the
cleansing on normal grounds, also did brain.

WWW.HEALTHSPECTRA.COM | MAY 2019 70

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IA71LA Growth Centre Annanangi, Praksham District - 523211, India. Ph: +91 859W3W-W2.H0E2A0LT0H7SPECTRA.COM | MAY 2019

DISEASE Could
mRNA be
WWW.HEALTHSPECTRA.COM | MAY 2019 a potent
treatment
for lung
diseases?

Lung diseases are
diverse and have the
potency to risk one’s
life too. But, if you are
here wondering one
can mRNA even rectify
the issues and help the
affected person lead a
healthy life, you are in
for a ride.

72

A new study/invention by the engineers from proteins. This specific criteria has been
the Massachusetts Institute of Technology used by a number of scientists to successful
have created an inhalable form of mRNA create genetic changes for an overall better
which can easily be administered directly to approach to the treatment. Owing to the
the lungs of the patient to treat their lung fact that the mRNA easily gets broken down
conditions like that of cystic fibrosis. in the body, it needs a carrier protein to take
it to the site of action.
Daniel Anderson, an associate professor in
MIT’s Department of Chemical Engineering In this study, the researchers wanted to
and the senior author of the study stated that produce an aerosol form of the mRNA which
the ability to deliver mRNA via the inhalation would allow the mRNA to be administered
process can easily help treat a number of directly to the lungs. This ideology came
problems and diseases associated with the from the aerosol spray and inhalers that
lungs. are often used to treat the condition of
hyperventilation and asthma.
In the conducted study, the researchers
were able successfully produce a healthy With that aside, the main approach and goal
amount of a specific bioluminescent protein of the team of researchers was to find a way
in the lung cells of the mice. According to the to stabilize the mRNA while it is administered
researchers, if the same kind of success can to the lungs. In some prior studies, the usage
be achieved with the normal therapeutic of polyethylenimine (PIE) has been quite
approaches, the same is expected to create predominant while the delivering of DNA to
a breakthrough in the treatments of the
lung diseases.

The lead author of the study, Asha Patel,
who is also an assistant professor in the
Imperial College, London was the one who
initially proposed the idea to opt for an
aerosol model for the treatment which did
turn out to be fruitful.

Using inhalation
process for the
treatment

The unique and the essential function
of the messenger RNA is the fact that it
helps stimulate the cells to produce target

73 WWW.HEALTHSPECTRA.COM | MAY 2019

DISEASE

the lungs. The only side effect of this carrier the lungs of the mice which gradually fell
is the fact that it doesn’t break down easily down in the ratio once the mRNA started
which can get accumulated on consistent clearing out from the lungs. The researchers
administration and cause side effects. were able to maintain a steady level of the
protein in the lungs with the administration
In order to overcome these shortcomings, of repeated doses of the aerosol.
the researchers opted for hyperbranched
poly (beta amino esters) which is a Further analysis
positively charged polymer and are easily
biodegradable. Even further and in-depth analysis of the
lungs found that the produced protein was
Following that, the team of researchers predominantly taken up by the five lobes
created spheres consisting of a mixture of not of the lungs, mainly focusing along the line
just the polymers but the mRNA molecules of the lung surfaces. These cells are often
as well which were subjected to encoding associated with that of cystic fibrosis which
luciferase which is a bioluminescent protein. was what paved way for the researchers to
The researchers then suspended these believe that this form of treatment would be
particles in droplets and administered the essentially beneficial for patients suffering
same to the mice via a nebulizer. from cystic fibrosis.

Patel clarified stating that the inhalation Patel further stated saying that since the
process is possibly the easiest of them all nanoparticles can be freezed, the same could
when it does come to the administration of actually be administered via the inhaler as
the medicine and the reaction of it in the well instead of aerosol which is believed to
lungs. Upon the dispersal of the particles make this an even better process. She is
in the lungs, they got instructed to finally working on a further analysis of the usage
produce the protein as per the mRNA of the mRNA therapies in the treatment of
instructs it to. the lung diseases in her lab at the Imperial
College, London. The study has been partially
Following 24 hours of the administration of funded by TranslateBio which is a company
the aerosol, the researchers found a steady dedicated to producing mRNA therapeutics.
presence of the bioluminescent protein in
74
WWW.HEALTHSPECTRA.COM | MAY 2019

DID YOU KNOW

DID YOU KNOW?

1 NEARLY 30% OF THE 2
3 WORLD’S POPULATION 4
5 IS OBESE

LEARNING A NEW
LANGUAGE OR PLAYING
AN INSTRUMENT BOOSTS

BRAIN FUNCTION

SKIN IS THE LARGEST
ORGAN OF THE BODY
WHICH DEFENDS AGAINST
DISEASE AND INFECTION

DRINKING COFFEE CAN
REDUCE THE RISKS OF
DEPRESSION

READING CAN KEEP
THE LEVELS OF STRESS
HORMONES IN CHECK

75 WWW.HEALTHSPECTRA.COM | MAY 2019

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