SACCHARIN, SODIUM SALT HYDRATE, 99+% -- = Sigma-Aldrich

7/23/2009 SACCHARIN, SODIUM SALT HYDRATE…

From: Subject: SACCHARIN, SODIUM SALT HYDRATE, 99+% -- Sigma-Aldrich Date: Fri, 16 Aug 2002
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Common Name SACCHARIN, SODIUM SALT
= HYDRATE,=20 99+%

Manufactured by Sigma-Aldrich

CAS Number 82385-42-0

Valid 08/01/2002 to = 10/31/2002

Source Sigma-Aldrich = (SAF.244317D)

1. Chemical Identification
2. Composition/Information on Ingredients
3. Hazards Identification
4. First-Aid Measures
5. Fire Fighting Measures
6. Accidental Release Measures
7. Handling and Storage
8. Exposure Controls/Personal Protection
9. Physical and Chemical Properties
10. Stability and Reactivity
11. Toxicological Information
12. Ecological Information
13. Disposal Considerations
14. Transport Information
15. Regulatory Information
16. Other Information

=20

Product #: 244317 Name: =

SACCHARIN, SODIUM SALT HYDRATE, 99+%

MATERIAL SAFETY DATA SHEET, Valid 8/2002-10/2002

-------------------------------------------------------------------------=

------

Sigma-Aldrich

3050 Spruce Street

St. Louis, MO 63103, US

Technical Phone: 314 771 5765

Emergency Phone: 314 771 5765

Fax: 800 325 5052

SECTION 1. CHEMICAL IDENTIFICATION

CATALOG #: 244317
NAME: SACCHARIN, SODIUM SALT HYDRATE, 99+%

SECTION 2. COMPOSITION/INFORMATION ON = 1/6
INGREDIENTS

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CAS #: 82385-42-0
MF: C7H5NO3S
SYNONYMS
ARTIFICIAL SWEETENING SUBSTANZ GENDORF 450 * =
1,2-BENZISOTHIAZOL-3(2H)-
ONE, 1,1-DIOXIDE, SODIUM SALT * CRISTALLOSE * CRYSTALLOSE * DAGUTAN =
*
KRISTALLOSE * MADHURIN * ODA * SACCHARINNATRIUM * SACCHARIN, SODIUM =
*
SACCHARIN, SODIUM SALT * SACCHARIN SOLUBLE * SACCHAROIDUM NATRICUM *
SAXIN * SODIUM 1,2 BENZISOTHIAZOLIN-3-ONE-1,1-DIOXIDE * SODIUM O-
BENZOSULFIMIDE * SODIUM BENZOSULPHIMIDE * SODIUM O-BENZOSULPHIMIDE *
SODIUM 2-BENZOSULPHIMIDE * SODIUM SACCHARIDE * SODIUM SACCHARIN *
SODIUM SACCHARINATE * SODIUM SACCHARINE * SOLUBLE GLUSIDE * SOLUBLE
SACCHARIN * SUCRA * O-SULFONBENZOIC ACID IMIDE SODIUM SALT *
SULPHOBENZOIC IMIDE, SODIUM SALT * SWEETA * SYKOSE * WILLOSETTEN *

SECTION 3. HAZARDS IDENTIFICATION

LABEL PRECAUTIONARY STATEMENTS
CAUTION:
AVOID CONTACT AND INHALATION.
TARGET ORGAN(S):
BLADDER

SECTION 4. FIRST-AID MEASURES

IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS =
CONSCIOUS.

CALL A PHYSICIAN.
IF INHALED, REMOVE TO FRESH AIR. IF BREATHING BECOMES DIFFICULT,
CALL A PHYSICIAN.
IN CASE OF CONTACT, IMMEDIATELY WASH SKIN WITH SOAP AND COPIOUS
AMOUNTS OF WATER.
IN CASE OF CONTACT WITH EYES, FLUSH WITH COPIOUS AMOUNTS OF WATER
FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING BY SEPARATING
THE EYELIDS WITH FINGERS. CALL A PHYSICIAN.

SECTION 5. FIRE FIGHTING MEASURES

EXTINGUISHING MEDIA
WATER SPRAY.
CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.

SPECIAL FIREFIGHTING PROCEDURES
WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO
PREVENT CONTACT WITH SKIN AND EYES.

UNUSUAL FIRE AND EXPLOSIONS HAZARDS
EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

SECTION 6. ACCIDENTAL RELEASE MEASURES

WEAR RESPIRATOR, CHEMICAL SAFETY GOGGLES, RUBBER BOOTS AND HEAVY 2/6
RUBBER GLOVES.
SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL.
AVOID RAISING DUST.
VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS =
COMPLETE.

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SECTION 7. HANDLING AND STORAGE

REFER TO SECTION 8.

SECTION 8. EXPOSURE CONTROLS/PERSONAL =
PROTECTION

SAFETY SHOWER AND EYE BATH.
MECHANICAL EXHAUST REQUIRED.
AVOID INHALATION.
AVOID CONTACT WITH EYES, SKIN AND CLOTHING.
AVOID PROLONGED OR REPEATED EXPOSURE.
NIOSH/MSHA-APPROVED RESPIRATOR.
COMPATIBLE CHEMICAL-RESISTANT GLOVES.
CHEMICAL SAFETY GOGGLES.
KEEP TIGHTLY CLOSED.
STORE IN A COOL DRY PLACE.
WASH THOROUGHLY AFTER HANDLING.

SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES

APPEARANCE AND ODOR
WHITE CRYSTALS

SECTION 10. STABILITY AND REACTIVITY

STABILITY
STABLE.

INCOMPATIBILITIES
STRONG OXIDIZING AGENTS

HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS
CARBON MONOXIDE, CARBON DIOXIDE
NITROGEN OXIDES
SULFUR OXIDES

HAZARDOUS POLYMERIZATION
WILL NOT OCCUR.

SECTION 11. TOXICOLOGICAL INFORMATION

ACUTE EFFECTS 3/6
MAY CAUSE SKIN IRRITATION.
MAY BE HARMFUL IF ABSORBED THROUGH THE SKIN.
MAY CAUSE EYE IRRITATION.
MAY BE HARMFUL IF INHALED.
MATERIAL MAY BE IRRITATING TO MUCOUS MEMBRANES AND UPPER
RESPIRATORY TRACT.
MAY BE HARMFUL IF SWALLOWED.
TO THE BEST OF OUR KNOWLEDGE, THE CHEMICAL, PHYSICAL, AND
TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED.

CHRONIC EFFECTS
THIS PRODUCT IS OR CONTAINS A COMPONENT THAT IS NOT CLASSIFIABLE AS
TO ITS CARCINOGENICITY BASED ON ITS IARC, ACGIH, NTP OR EPA
CLASSIFICATION.
TARGET ORGAN(S):
BLADDER

RTECS #: DE4550000
1,2-BENZISOTHIAZOLIN-3-ONE, 1,1-DIOXIDE, SODIUM SALT

TOXICITY DATA

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ORL-RAT LD50:14200 MG/KG FCTXAV 6,313,1968
IPR-RAT LD50:7100 MG/KG FCTXAV 6,313,1968
ORL-MUS LD50:17500 MG/KG FCTXAV 6,313,1968

IPR-MUS LD50:6 GM/KG USXXAM #4869913
TARGET ORGAN DATA

KIDNEY, URETER, BLADDER (BLADDER TUMORS)
EFFECTS ON FERTILITY (MALE FERTILITY INDEX)
TUMORIGENIC (NEOPLASTIC BY RTECS CRITERIA)

TUMORIGENIC (TUMORS AT SITE OF APPLICATION)
ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
(RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR

COMPLETE INFORMATION.

SECTION 12. ECOLOGICAL INFORMATION

DATA NOT YET AVAILABLE.

SECTION 13. DISPOSAL CONSIDERATIONS

CONTACT A LICENSED PROFESSIONAL WASTE DISPOSAL SERVICE TO DISPOSE OF
THIS MATERIAL.
DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN =
A
CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER.
OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.

SECTION 14. TRANSPORT INFORMATION

CONTACT ALDRICH CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.

SECTION 15. REGULATORY INFORMATION

EUROPEAN INFORMATION

CAUTION: SUBSTANCE NOT YET FULLY TESTED.

REVIEWS, STANDARDS, AND REGULATIONS

OEL=3DMAK

IARC CANCER REVIEW:ANIMAL SUFFICIENT EVIDENCE IMEMDT 22,111,1980

IARC CANCER REVIEW:ANIMAL SUFFICIENT EVIDENCE IMEMDT 73,517,1999

IARC CANCER REVIEW:HUMAN INADEQUATE EVIDENCE IMEMDT 73,517,1999

IARC CANCER REVIEW:GROUP 3 IMEMDT 73,517,1999

NOHS 1974: HZD 80527; NIS 17; TNF 2086; NOS 22; TNE 13433

NOES 1983: HZD X8578; NIS 1; TNF 11; NOS 5; TNE 1150; TFE 591

NOES 1983: HZD 80527; NIS 18; TNF 1735; NOS 44; TNE 67252; TFE 49525

EPA GENETOX PROGRAM 1988, POSITIVE: RODENT DOMINANT LETHAL; D

MELANOGASTER SEX-LINKED LETHAL

EPA GENETOX PROGRAM 1988, POSITIVE/DOSE RESPONSE: IN VITRO SCE-HUMAN

LYMPHOCYTES

EPA GENETOX PROGRAM 1988, POSITIVE/DOSE RESPONSE: IN VITRO =

SCE-HUMAN;

IN VITRO SCE-NONHUMAN

EPA GENETOX PROGRAM 1988, NEGATIVE: HISTIDINE REVERSION-AMES TEST;

SPERM MORPHOLOGY-MOUSE

EPA GENETOX PROGRAM 1988, INCONCLUSIVE: D MELANOGASTER-RECIPROCAL

TRANSLOCATION

EPA TSCA SECTION 8(B) CHEMICAL INVENTORY

SECTION 16. OTHER INFORMATION 4/6
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7/23/2009 SACCHARIN, SODIUM SALT HYDRATE…

THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT =
TO

BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,
FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM =
HANDLING
OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE =
OR
PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.
COPYRIGHT 2001 SIGMA-ALDRICH CO.
LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY

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