Alnylam Assist: Screening for Familial Amyloidotic

FREE Alnylam Assist:
Screening Screening for Familial Amyloidotic
Program* Polyneuropathy (FAP) or Familial
Amyloidotic Cardiomyopathy (FAC)
in TTR Amyloidosis

Alnylam Pharmaceuticals, Inc.
is committed to advancing the
diagnosis and treatment of FAP
and FAC.

As part of our commitment, Alnylam is now
sponsoring free third-party screening for patients
who may carry a genetic mutation known to be
associated with FAP or FAC.

*Currently available only in the US.

FREE Why screen your patients for Familial
Screening Amyloidotic Polyneuropathy (FAP) or
Program* Familial Amyloidotic Cardiomyopathy (FAC)

FAP and FAC are an inherited genetic disorders caused by deposition of liver-
derived TTR amyloid in various tissues and organs. These progressive conditions
remain significantly underdiagnosed and have limited treatment options.

Diagnosing FAP and FAC can be a challenge.
Patients often exhibit symptoms commonly associated with idiopathic
polyneuropathies and/or heart failure. To promote accurate diagnosis and
appropriate treatment, Alnylam Assist offers free third-party screening for
family members of patients diagnosed with FAP or FAC as well as for patients
experiencing clinical signs and symptoms of these conditions.

FAP symptoms experienced at disease onset FAC: Symptoms at Presentation (Patients %)
Sensory symptoms Previous carpal tunnel syndrome1

Loss of touch/pain 82% 35%

Tingling/“pins and needles” 80% Sleep apnea syndrome2

Motor symptom 95%

Weakness 67% Conduction abnormalities3a

Autonomic symptoms 68%

Constipation/diarrhea 55% 99% Essentially all patients present with
Sexual dysfunction 53% some form of cardiomyopathy:4
• Heart failure signs and/or symptoms
Source: Suanprasert N, et al. J Neurol Sci 2014. • IVS >12 mm
• LV diastolic dysfunction
• Low voltage ECG

aFirst assessment in THAOS registry
IVS: interventricular septal thickness

1 Longhi S, et al. Eur Soc Cardiol Congress 2014 (Abstract P6149);
2 Bodez D, et al. Eur Soc Cardiol Congress 2014 (Abstract P6543);
3 Coelho T, et al. Curr Med Res Opin 2013;29:63–76;
4 Connors LH, et al. Am Heart J 2009;158:607–14

*Currently available only in the US.

Alnylam Assist:
Simple, Complimentary Screening†

Complete the included LabCorp account setup form
Form for FAP or FAC testing is enclosed

Complete LabCorp requisition form
To be sent by LabCorp after account setup is completed.
To ensure your practice or patient will not be billed, please
use the requisition form sent by LabCorp only for the
FAP or FAC Screening Program.

Submit the requisition form to LabCorp
Phone: 1.919.474.4326 | Fax: 1.919.474.4382
E-mail: [email protected] | Attention: Jill Hulford

Take a 4 mL whole blood sample
Use a standard 4.0 mL lavender-top (EDTA) tube

Send the sample to LabCorp
Shipping and specimen handling instructions are provided by
LabCorp after account setup

Receive your patient’s results in 2-3 weeks
Results will be faxed to your clinic

For assistance with the LabCorp account setup form, contact LabCorp by calling 1.919.474.4326.
For more information about FAP or FAC, contact Alnylam by calling 1.866.330.0326.

†Alnylam will not receive any personally identifiable patient information through this screening program.

“Alnylam Assist represents an important step forward in
providing patients and caregivers a tool for identifying a
disease that is often underdiagnosed.

For our patients who may not have the means to afford genetic
screening, this free, third-party program will remove a major barrier
to early diagnosis of this dreadful disease.

For caregivers, this program represents progress towards
implementing a management strategy potentially earlier in the disease
process for our patients who suffer from this genetic disorder.”

Ola Akinboboye, MD, FACC
Past President, Association of Black Cardiologists
Associate Professor of Clinical Medicine, Weill Medical College of Cornell

Alnylam is a biopharmaceutical company
developing a new class of innovative
medicines. We have a core focus on
therapeutics toward genetically defined
targets for the treatment of serious,
life-threatening diseases with limited
treatment options for patients and
their caregivers.

Learn more about Alnylam’s clinical trial of
a potential new treatment for FAP or
FAC. Visit www.ClinicalTrials.gov or call
1.866.330.0326 for more information.

© 2015 Alnylam Pharmaceuticals, Inc.
300 Third Street | Cambridge, MA 02142 USA
2.26.2015

Alnylam Assist: Free Screening for Familial
Amyloidotic Polyneuropathy (FAP) or Familial
Amyloidotic Cardiomyopathy (FAC)*

Your doctor believes you should be screened for
familial amyloidotic polyneuropathy (FAP) or familial
amyloidotic cardiomyopathy (FAC), an inherited
genetic disease.

Alnylam offers you this screening through an independent
laboratory free of charge. Early diagnosis can assist patients
with FAP or FAC in getting the help and support they need.

How To Get Screened If your results are positive

1. Provide a blood sample When your results arrive, your doctor
will tell you if you have a genetic mutation
Screening for FAP or FAC takes a small known to be associated with FAP or FAC.
amount of blood. If you do, you are encouraged to discuss
health care options with your doctor.
2. G et your results from
your doctor If you need treatment, options may include
drug therapy or participation in a clinical trial.
FAP or FAC screening results usually arrive To learn more about clinical trials for FAP
in 2-3 weeks. or FAC, visit www.ClinicalTrials.gov.

*C urrently available only in the US.
Alnylam will not receive any personally identifiable patient information through this screening program.

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 


 

 

 

Account Setup Form


 

Project Name: TTR Amyloidosis DNA Sequencing Testing



   

 

Account Information:

Practice Name:

Practice Address: State: Zip:


 

City:

 
Contact Name (first, last):

Contact email:

Physician Name (first, last): NPI#:

 
Practice Fax:
Practice Phone:

 
Number of Test Requisition Forms Needed:

Your Alnylam Rep:

Will you collect samples in your office:

Yes No

Please provide fax number where you would like to receive results:


 

Autofax (provide fax number):

Signature of person completing the form: ____________________________________________
 


 
**
 All
 charges
 will
 be
 incurred
 by
 Alnylam**
 

 


 

Please allow approximately 7-10 business days from receipt of a completed form for account setup.


 

Please email the completed form to [email protected] or call at (919) 474-4326.