DOS_oct_2009

To Compare Macular Thickness Measurement in Abstracts
Normal Eyes with Time Domain and Fourier Domain OCT

*Jingjing Huang, MD, *Xing Liu, MD, PHD, **Ziqiang Wu, MD, *Hui Xiao, MD, **Laurie Dustin, MS, ***Srinivas Sadda, MD

Retina Journal 29(7):980–987, July/August, 2009

*Zhongshan Ophthalmic Center ,Sun Yat-Sen University,Guangzhou, China. **Centre For Advanced Eye Care,Carson University,
Nevada. ***Keck School Of Medicine,La

The evolution of OCT has been a stepwise process, starting from the prototype through the development of the first, second, and third
generations of commercially available instruments. Each successor had been an improvement over the predecessor in terms of
imaging speed and resolution, but the underlying concepts had largely remained the same. In these so-called time domain

OCTs (TDOCT), a mechanical moving mirror is crucial for extracting depth information for light reflected from the retina. Therefore,
data acquisition speed is limited by the relatively slow mechanical movement.

In Fourier-domain OCT (FDOCT), the light interference pattern of an entire A-scan is detected simultaneously with spectrally
separated detectors (diffraction grating) and a linear detector array (a high-speed charge coupled device, or CCD, camera). Fourier
transform is used to mathematically convert the raw data into A-scan data to be displayed as a false-color map, just like previous
generations of OCT. By eliminating the disadvantage of a mechanical moving part, FDOCT can generate images at far greater speed,
which is only limited by the camera’s frame transfer rate and computer speed. For example, the RTVue- 100 FDOCT (Optovue,
Fremont, CA) can perform 26,000 A-scans per second according to its user’s manual, or approximately 65 times faster than Stratus-
OCT.

This study was conducted to compare macular thickness measurements using time-domain optical coherence tomography (OCT) and
Fourier-domain OCT.

METHODS

Thirty-two eyes from 32 normal patients underwent complete ophthalmic evaluation.

Macular scanning using the StratusOCT and the RTVue-100 OCT were performed for a total of three times each on the same visit. The
average retinal thicknesses of the nine macular sectors as defined by the Early Treatment Diabetic Retinopathy Study, along with the
foveal center point and macular volume, were recorded. The SD, the coefficient of variation, and the intraclass correlation coefficient
were calculated for each parameter studied. Comparisons were made between the two OCTs in terms of retinal thicknesses
measurements, their reproducibility, and macular regional differences. Correlations between retinal thickness and demographic
variables (age and gender) were also investigated. Due to known differences in segmentation algorithms of the two OCTs, software
calipers were used to measure the distance from the internal limiting membrane to the photoreceptor inner segment–outer segment
junction at the foveal center point on all RTVue scans to allow a more fair comparison.

RESULTS

The RTVue yielded greater retinal thickness measurements in nearly all macular subfields compared with the StratusOCT. Even after
accounting for differences in segmentation algorithms, significant disparities were still evident with the RTVue measurements less than
those of the StratusOCT at the foveal center. On both machines, the macula was thinnest at the fovea and thickest within the 3 mm ring.
Compared with the StratusOCT, the RTVue generally had lower coefficients of variation and higher intraclass coefficients, suggesting
better reproducibility.

CONCLUSION

Compared with StratusOCT, the RTVue Fourier-domain OCT yields greater retinal thickness measurements with greater reproducibility,
presumably due to different segmentation algorithms, increased sampling density, and greater resolution.

www.dosonline.org 71

Functional And Anatomic Change Evaluation With
Bevacizumab In Macular Edema-A Prospective Non Randomized,

Interventional Case Series

Raimondo Forte, MD, Gilda Cennamo, MD, Elisabetta Chiariello Vecchio, MD,
Raffaele Tenore, MD, Bernardino Aufiero, Cot, Giuseppe De Crecchio, MD

Retina Journal 29(7):941–948, July/August, 2009

Eye Department, University Federico, Naples, Italy

The main purpose of the study was to evaluate in a prospective fashion the early functional and anatomic response rate of macular
edema to intravitreal Bevacizumab, not depending on the etiology of the edema

This study evaluated the early rate of change of BCVA, Central retinal sensitivity (SLO OCT/Microperimetry) and Central retinal
thickness (OCT) in patients of macular edema.

37 consecutive eyes with newly diagnosed macular edema due to CNV secondary to AMD-(23), RAP (8-retinal angiomatous proliferation),
branch&central retinal vein occlusion (6).

METHODS

Two intravitreal injections of Bevacizumab (0.05 mL solution prepared from Avastin 100 mg/4 mL; Genentech, South San Francisco,
CA) were given in all patients through the pars plana at baseline and after 1 month. VA, OCT, Microperimetry evaluation was done at
baseline, 7, 15, 30, 37, 45 and 60 days. OCT was done for anatomical improvement and Microperimetry for the functional improvement.
Fundus-related Microperimetry was performed using the SD-SLO/OCT. The SD-SLO/OCT includes an automated tracking system to
compensate in real time for any eye movement. In the SD-SLO/OCT system, the map of retinal sensitivity can be automatically
overlapped on the OCT RT topographic map to associate each sensitivity value with a thickness value.

RESULTS

BCVA progressively improved during the month after the first injection, decreased to near baseline values during the first 2 weeks after
the second injection i.e. 6 weeks after 1st injection, and improved again after 2 weeks from the second injection. The greatest improvements
occurred during the third and fourth week after each injection.

The temporary decline observed in this study could be related to a reduction of the effects of the first injection. Retinal sensitivity by
Microperimetry improved during follow-up, although a low correlation was found with BCVA. A reduction of the mean RT in the 3-
mm-diameter central ring as measured with OCT was seen during follow-up. A significant reduction of RT was seen after 2 months
when compared with baseline.

CONCLUSION

BCVA showed a peak improvement after 4 weeks of both the injections with a decline in the 5 and 6th week, while the Reduction of
retinal thickness (OCT) and functional improvement (Microperimetry) was seen throughout the study.

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72 DOS Times - Vol. 15, No. 4, October 2009

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Delhi Ophthalmological Society
Monthly Clinical Meeting, December 2009

Venue: Lecture theatre complex behind New OPD Complex,
Vardhman Mahavir Medical College & Safdarjang Hospital New Delhi

Date and Time : Sunday, 27th December 2009, 11:00 AM

10.30 AM: Breakfast

11.00 AM onwards

Clinical Cases: : Dr. Shivani Kochhar 10 min.
1. Glaucoma surgery in youngest child (6 days old) : Dr. Aniket N. Shastri 10 min.
2. Intra Orbital Foreign Body

Clinical Talk: : Dr. B.P. Guliani
Ultrasonography of eye
Mini Symposium: Oculoplasty

Chairman: Dr. K.P.S. Malik, Co-chairman: Dr. V.S. Gupta

1. Frontalis Sling Surgery for Ptosis –Made Easy : Dr. Anuj Mehta

2. Fracture floor repair-No scar technique : Dr. Sangeeta Abrol
3. Conjunctival DCR : Prof. V.P. Gupta
4. Management of Ectropion : Dr. Ruchi Singhal

20 Early Bird Prizes Lunch 1:00 p.m.
Sponsored by: Sun Pharmaceuticals

78 DOS Times - Vol. 15, No. 4, October 2009