Acute NSAID overdose symptoms include reversible effects like apathy, drowsiness, nausea, vomiting, and epigastric pain. Rarely, serious complications such as gastrointestinal bleeding, arterial hypertension, renal failure, and respiratory depression may arise. Anaphylactoid reactions are possible even with therapeutic doses. Overdose treatment involves symptomatic support; no specific antidotes exist. Nimesulide's high protein binding reduces effectiveness of measures like hemodialysis. Within 4 hours of overdose, vomiting, activated charcoal, or laxatives can be considered. Kidney and liver function monitoring is crucial, while interventions like forced diuresis may prove ineffective due to protein binding.