In response to the COVID-19 crisis, a Unified Emergency Operations Center (UEOC) was established in March 2020 in the county of Milwaukee to facilitate efforts among local government, fire and EMS, law enforcement, public health, health care, academia, the business community, and other stakeholders. The purpose of the UEOC is to coordinate and elevate a unified multi-sector public health response to COVID-19’s direct and indirect effects, with emphasis on affected vulnerable populations.