labeling, 135, 137, 138, 144, 154, 168–169 Lake, Ricki, 91, 114 Langevin, Helene, 40 laudanum, 14 law. See legal status Leary, Timothy, 12 Leary v. United States, 12 legal status, 8–13, 17–19, 167–168. See also regulation lemonade, 152 Levee District, 7–8 Lewis, Ray, 100 Lewis, Ryan, 17, 18, 24, 35, 38, 100, 116 LGBTQ community, 145 lot number, 138 lottery, 156 M MAGL. See monoacylglycerol lipase (MAGL) Maine, 9 Makriyannis, Alexandros, 107–110 Mandel, Case, 100 “marihuana extract rule,” 18 Marijuana Tax Act, 9–10, 12 Marinol, 4 Marley, Ziggy, 117 Massachusetts, 9 mechanical extraction, 131–132 Mechoulam, Raphael, 2, 3, 5, 23, 32, 38, 96, 110–113
medical marijuana, 14–15 mental illness, 59–65, 89. See also anxiety Merritt, John, 35 Mexico, 9 microdosing, 136 Middle Ages, 6 migraines, 70–73 mixology, 151 monoacylglycerol lipase (MAGL), 2, 77 MS. See multiple sclerosis (MS) multiple sclerosis (MS), 37–38 N Nabilone, 5 nausea, 75–78 neurotransmitters, 2, 87–88, 89 newspapers, 10 New York, 9 NMDA receptor, 105 O Obama, Barack, 14 obesity, 82–85 oil carrier, 140 CBD, 140–142 decarboxylation of, 142
hemp, 141 oleoyl serine, 112 olive oil, 140 opioid crisis, 22–23, 103–104 organized crime, 156 O’Shaughnessy, William Brooke, 7 osteoporosis, 65–67 oxidative stress, 86, 105–106 P pain, chronic, 36–41 in cancer, 92–93 GABA and, 88–89 incidence of, 21–22 inflammation and, 38–39 opioid crisis and, 22–23, 103–104 THC and, 36–37 palliative care, 66 Parkinson’s disease (PD), 52, 102 patches, transdermal, 150–151 PD. See Parkinson’s disease (PD) personal appearance, 46–50 pets, 170–172 Philips, Joy A., 38 physical fitness, 67–68 phytocannabinoids, 4, 93, 97 PMS. See pre-menstrual syndrome (PMS) poisoning, 155
post-traumatic stress disorder (PTSD), 5, 66 pre-menstrual syndrome (PMS), 66 products, 136–152 prohibition, 156 Proposition 215 (California), 15 psychosis, 59–65 PTSD. See post-traumatic stress disorder (PTSD) Pure Food and Drug Act, 8–9 Q QR code, 138 quality, 136–152 R race, 9 Reagan, Nancy, 13 Reagan, Ronald, 13, 73 rebound headaches, 70 regulation, 153–156. See also legal status Republican Party, 13 reputation, of producers, 137–138 Rice, Amanda, 24, 116 “rich,” in labeling, 168–169 rope, 11 Royal Canadian Legion, 123 Russo, Ethan, 71, 96, 101–105 Ryan, Tracy, 84, 113–119
S sails, 11 salves, 149–150 San Francisco, 14–15 schizophrenia, 62–64 seizures. See epilepsy self-titration, 135–136 shampoo, 149–150 shelf life, 174–175 Shurtleff, David, 40 Simpson, Rick, 119–124, 142 skin care, 46–50 sleep, 50–53, 66 smoking, 53–55, 91 social drinking, 169–170 softgels, 142–143 soil conditions, 138 Solian, 62 Solomon-Lautenberg Amendment, 13 solvent extraction, 132 Spice (synthetic cannabinoid), 108–109 sports, 67–70 baseball, 68 basketball, 68 football, 68 stomach upset, 75–78 synthetic cannabinoids, 4, 5, 108–109
T tabletop vaporizer, 145–146 TBI. See traumatic brain injury (TBI) tea, 152 tennis, 68 testing, drug, 165–166 THC addiction to, 36 allowed in CBD products, 17 CBD vs., 1 discovery of, 3 dogs and, 172 evolution of, 3 pain and, 36–37 THCa, 116 tinctures, 143–144, 154, 174–175 tobacco, 91 tobacco cessation, 53–55, 113 Todd, Alexander, 111 tolerance, 38 topicals, 149–150 traditional Chinese medicine, 6 transdermal patches, 150–151 transient receptor potential vanilloid-4 (TRPV4), 48 trauma, 65–70 traumatic brain injury (TBI), 35 trichomes, 22, 109
TRPV4. See transient receptor potential vanilloid-4 (TRPV4) Truman, Harry, 11–12 trust, 153–156 U United States, cannabis in, 6–21 V Valeant Pharmaceuticals, 5 vaping, 144–147, 153 cartridges, 145 vaporizer, 145–146 veganism, 170 vomiting, chemotherapy-related, 5. See also nausea Vote Hemp, 16 W Washington, George, 7, 60–61 “weasel words,” 140 weight gain, 83–84 wellness, 158–161 white fat, 84–85 whole-plant, isolates vs., 168 wild claims, 137 wine, 152 withdrawal, from alcohol, 58–59
World War II, 11 X X-ray crystallography, 109 Y Yolo CBD Oil, 154–155