Impact Report 2018

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With your
support, we
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hudsonalpha.org/foundation
[email protected]
601 Genome Way
Huntsville, Alabama 35806
256.327.0422

TGREANNOSMLAITCISNG
into real-world applications to make
a healthier, more sustainable world

More than a decade ago, two visionaries connected and collaborated
to create one of the most unique life science ecosystems to date,
HudsonAlpha Institute for Biotechnology.
HudsonAlpha Institute for Biotechnology’s mission is four fold.
First, our scientists conduct groundbreaking research to
pursue discoveries that advance our understanding of human
disease and agriculture. Second, our teams use genomic medicine
to help children and adults struggling to find answers for
their undiagnosed diseases. Our education team equips
teachers, students and lifelong learners with educa-
tional tools. Finally, our economic development
group attracts collaborative business ventures aDrrereeabaleimiznsegdac-rhealbinvegienesdg.
to move life sciences research from the lab to
real-world solutions.

HudsonAlpha is one of the top DNA sequencing
centers in the world. We use sequencers not
only for our own work but also for research
projects around the world. We also support
patient care by providing the most advanced genetic - jim hudson
information available to top institutions such as the co-founder

Mayo Clinic, St. Jude Children’s Hospital and more
than 6,000 others across the globe.
The HudsonAlpha campus is home to not only the nonprofit re-
search and education programs, but also to dozens of independently
run for-profit companies working to bring discoveries to market
and eventually to patients. With a unique model of collaboration,
we are uniquely positioned to accelerate innovation. We believe that the
promise of genomics drives discovery forward, improving health and
well-being for all in both human health and agriculture.
The HudsonAlpha Foundation is a nonprofit organization that
grows and stewards private support to advance genomic discoveries
and science education at the HudsonAlpha Institute for Biotech-
nology. We help donors achieve their philanthropic goals while
impacting human health and sustainability.
For more information on how you can support HudsonAlpha
and make a lasting difference, visit hudsonalpha.org/foundation or
contact the Foundation office at [email protected]
or 256-327-9446.
Thank You!

The HudsonAlpha Foundation, a 501(c)(3) nonprofit organization, is the supporting entity for the HudsonAlpha
Institute for Biotechnology. Tax-deductible contributions to the Foundation are for the sole purpose of advancing the
mission of the HudsonAlpha Institute for Biotechnology. 
Tax identification #27-2320591

Cancer

Cancer is, at its heart, a genetic disease, a progression
from normal cells to abnormal, precancerous, then
cancer cells. For that reason, some of the most prom-
ising advances in cancer research involve genomics.

HudsonAlpha researchers are exploring opportunities
for earlier detection, monitoring, better treatment
plans, and new drug targets for those facing various
cancer diagnoses including breast, ovarian, kidney,
colon, pancreatic, prostate and more.

HcouldosnonpAollpyhpamsacrikenertsists find Early detection of kidney cancer

Colonoscopy is the most commonly performed In 2014, HudsonAlpha scientists identified a panel of
endoscopic procedure in the United States and is biomarkers that are strong predictors of kidney cancer.
the preferred method to screen for colon cancer, In 2016, HudsonAlpha and the University of Alabama
but it certainly is not a comfortable procedure. at Birmingham identified gene expression changes associated
More than 60% of Americans aged 50 and older with kidney cancer. The goal now is to refine these biomark-
have not utilized current screening methods for ers into a non-invasive test for kidney cancer and better
colon cancer. Imagine if there were a better way. monitoring of cancer’s return and its response to certain
drugs. Researchers at HudsonAlpha are collaborating with
HudsonAlpha Institute for Biotechnology researchers the University of Alabama at Birmingham’s Comprehensive
announced the discovery of a measurable indicator Cancer Center to further test the models.
in blood plasma that could identify patients who “HudsonAlpha, one of the top genetic sequencing centers in
have colon polyps. The finding is an important the nation, and UAB, a premier medical research institution,
first step in developing a blood test to screen for can together change the standard of care for cancer patients
colon polyps that could become cancerous or by diagnosing patients earlier and using the right treatment
even for colon cancer. for the right person at the right time,” said Dr. Rick Myers,
HudsonAlpha president and science director.

IConmfmounritmy caantcieropnrogirsamP: ower

Since 2015, HudsonAlpha, in collaboration with Kailos Genetics, has
offered a groundbreaking, community-wide cancer initiative. Information
is Power offers free and reduced cost genetic cancer screening for the
well-known BRCA1 and BRCA2 genes, as well as more than 30 additional
genes linked to an increased risk of breast, ovarian, colon and other types
of cancers. Thank you to Redstone Federal Credit Union and Russell Hill
Cancer Foundation for their support of the initiative.

nearly 4,000 people have taken the
Information is Power test. of those
testing positive for an increased risk

of cancer, nearly three-fourths
had little or no family history.

Every day,
more than 1,500
oATohmfnaeectrap’isnecrcaasebnorosn.udtie
every minute.

We’re working really
hard in the cancer field,

including here at
HudsonAlpha, to try
to identify biomarkers

that we can use to
develop more drugs that
can help more people.

- Sara Cooper, PhD
Faculty investigator

Nhoeofauersvleyehoroynledsoesvuinetn
the United States
is affected by a
neurological
disease.

These neurological
diseases are all
connected. Studying one
of them will advance
our understanding and
knowledge of

them all.

- rick myers, PhD
president and science director

NDIESUERAOSELSO&GIDCiAsLorders
These devastating conditions, which cause the pro-
gressive loss of memory, mobility, cognition, or com- Understanding the genetic
binations of each, have no cure. Some are impossible causes of these devastating
to even predict. Genomic technologies hold incredi- diseases will enable researchers
ble promise to help untangle diseases like Alzheimer, to better identify promising
Huntington, ALS, Parkinson, frontotemporal de-
mentia and corticobasal degeneration (CBD). treatments and, hopefully
point towards a path for a cure.
HudsonAlpha researchers are investigating the genet- Impacting ALS
ic factors in neurodegenerative diseases. All neuro-
logical diseases are as interconnected as the nervous Scientists at HudsonAlpha, in collaboration with other
system itself. Finding answers about one disease may academic institutions and industry scientists, identified 11
lead to answers about many. Our research has led to new genes associated with ALS. Building on the success
the discovery of new genes which helps the drug de- of these discoveries, we are now working on a clinical re-
velopment pipeline provide targeted therapies. search project with Crestwood Medical Center to se-
quence the genomes of ALS patients and their immediate
Mental health disorders, like schizophrenia and families. Using our team science approach and collab-
bipolar disorder, are biological diseases with genet- orating with physicians, we hope to make an even greater
ic underpinnings just like cancer or other genetically impact on ALS.
linked diseases. HudsonAlpha researchers are using
high-throughput genomics techniques to understand dCoislcloavbeorriaetsing for Huntington
major depression, bipolar disorder and schizophrenia
to increase our understanding of these diseases. Huntington disease is caused by an inherited defect in
a single gene. Individuals who have this incurable dis-
Memory and Mobility Fund ease carry one gene with the defect and another - one
The HudsonAlpha Foundation has established the from each parent. More than 30,000 Americans suffer
Memory and Mobility (M&M) fund to support ge- from Huntington disease, and another 200,000 are at
nomics research of neurological diseases. In collab- risk for inheriting the disease. In an effort to develop a
oration with top institutions, such as the University therapy for this neurological disease at its genetic source,
of Birmingham Kirklin Clinic, University of Cali- HudsonAlpha scientists are using their expertise to un-
fornia San Francisco, University of California Santa derstand how the huntingtin (HTT) gene is turned on
Barbara, and others, HudsonAlpha is poised to make and off. With the Huntington disease gene turned off,
significant contributions to the normal gene can continue to function and new ther-
finding the underpinnings apies to treat the disease couldbedeveloped.Applicationof
of these diseases. this gene editing technique can be used for other neuro-
memory and mobility program logical diseases.

IamnpdaFcTtLinDg Alzheimer disease

HudsonAlpha scientists contributed to the discovery
of a newly-identified risk factor for one of the more
common forms of early-onset dementia, frontotem-
poral lobar degeneration (FTLD). The researchers
found that variation in the MFSD8 gene associates
with a greater risk of developing FTLD, a disease that
often has an early age of onset, and which can in-
clude difficult-to-manage symptoms, ranging from
inappropriate social behaviors to speech problems.
The finding will help researchers by narrowing the
focus for potential diagnostics and one day even
treatments. We expect to identify more varients as we
continue to study these diseases.

CGDhiesniolerdtdhiceorosd

Physicians often cannot make a diagnosis or identify the cause of a
child’s condition, leaving parents with painful questions and uncertain-
ty about their child’s future. Through genomic sequencing, we have
been able to diagnose more than 30 percent of children enrolled
in HudsonAlpha’s clinical research projects. Only five years ago,
this statistic was less than 15 percent. Advancements and new diagnoses
are happening very rapidly. Genetic diagnoses have ended many fam-
ilies’ diagnostic odysseys, allowing parents and children to access much
needed support and new treatment options.

Sequencing newborn babies in the NICU

In an effort to help patients and families earlier in the diagnostic journey,
HudsonAlpha scientists are sequencing neonatal intensive care unit
(NICU) babies across the south through a program called South-

Seq. The project provides whole genome sequencing (WGS) for
babies born with a congenital disease. The whole genome se-
quencing test looks at a person’s entire genetic code and finds
genetic changes that may be the cause of medical prob-
lems. SouthSeq hopes to provide doctors with the
tools for earlier diagnoses and a pathway for better
care and treatments.

RALA and SCN1A

HudsonAlpha scientists link gene to developmental delay. They
found that variations on a gene called RALA are linked to a set
of developmental delays and intellectual disabilities. Patients with
the variation all had speech problems, and most had muscle issues
and were unable to walk.
HudsonAlpha researchers have pinpointed a previously
unknown cause of a serious seizure disorder most common in
babies, potentially opening the door to new diagnostic and treatment
options for infants that show signs of epilepsy. They found
the genetic cause hidden in the SCN1A gene, one of the most
heavily studied genes for seizure disorders.

Two out of every 100
children are born with
an intellectual or
physical disability
or developmental delay.

Together, we are able to
diagnose known conditions
that are otherwise difficult or
impossible to diagnose without
DNA sequencing. We can then
leverage the data we generate
to make new discoveries, which
in turn eventually lead to

new diagnoses.

- greg Cooper, PhD
Faculty investigator

Teshteimreataerde25anto 30
million Americans
living with an
undiagnosed
disease

A diagnosis is the
first success for
patients with unknown
disease. It opens up
a world of possibilities.
A course of treatment.
A new drug.
Perhaps, even a cure.

- david bick, md
Faculty investigator and

clinical geneticist

SCGmleiinntohicmFfaiocmrMileydicine

Changing medicine through the hero
clinical genomics fund

Opening in 2015, the Smith Family Clinic for Genomic Medicine The Hero Fund was established
leverages the sequencing and diagnostic expertise of HudsonAlpha’s through an anonymous and generous
physicians and scientists in a clinical setting. Through the power of gift to provide support for patients in
genomic medicine, it is now possible to make diagnoses that may
have been impossible before. Based on a patient’s symptoms, the need of genomic diagnoses.
clinic uses whole genome sequencing or other appropriate genetic
testing to find answers to patients underlying medical conditions.
The data found from the genomic sequence is then interpreted to
identify variants, or changes in the DNA, linked to disease.

Finding hope in the Hero Fund

Rare disease patients spend an average of eight years searching
for a diagnosis, and for some, that search can last decades.

April Hudson of Quinton, Ala., began showing symptoms
of an unknown disease at three years old.
She would go on to see 200 physicians be-
fore finally learning the true cause of her
symptoms nearly 40 years later. After learning
about HudsonAlpha, April got in touch with
the Smith Family Clinic and was not only
accepted as a patient, but also was able to
use the Hero Fund, which provides finan-
cial assistance to qualified Smith Family
Clinic patients.
After 40 years of doctors appointments,

failed surgeries and misdiagnoses, whole genome sequencing led
to the correct diagnosis. April had a change in the NLRP3 gene,
which is associated with familial cold autoinflammatory syn-
drome (FCAS). FCAS is a very rare condition that causes fever,
skin rash, and joint pain after exposure to cold temperatures.

“It tied everything together,” said April. “The more research
I did on the NLRP3 gene and the mutations associated with the
disease, the more it made sense.”

Although there is no cure for FCAS, April is able to move
forward and treat her condition. She is seeing an immunologist
and is on a medication that already is helping her.

Immunogenomics

By applying immunogenomics
to cancer research, HudsonAlpha
scientists hope to better
understand the relationship
between the immune system
and tumor cell development,
identifying pathways to
reverse or slow tumor
formation.

Immunogenomics explores the application of
genomic technologies to better understand the
immune system and immune-related disorders.
Human immune systems are complex and diverse.
Using genomic sequencing, scientists can map an
individual’s immune repertoire (the diversity, health
and activity of different parts of the immune system)
to provide both a historical record of a person’s health
as well as an indicator of current health problems.

HudsonAlpha faculty investigator Jian Han, MD,
PhD, was the first to develop and apply special
techniques in immunogenomics. His analytic
method allows deep sequencing of the immune
repertoire to reveal the effects of disease on the
immune system. The immune repertoire can allow
clinicians to detect disease long before symptoms
appear or are recognized, possibly making early drug
therapies more effective.

The Human immune
system is the body's
protection system.
is8ny0s%ttehomef’sitanchtteeivsiimttiymnhueansp.epens

Everything is related
to the immune system.
Our immune system is
the smartest and best
doctor around, and if
we can learn from

the best, we can
be better.

- Jian han, MD, PhD
Faculty investigator

The power of
genomics...
inspiringsociety
to engage in
life sciences.

The Educational Outreach
team provides educational
tools for learners of all ages

and our programming
extends from early career
exploration for children
to in-depth workshops for

senior citizens.

- neil lamb, phd
vice president for
Educational Outreach

Education

Educational outreach has been a
critical part of HudsonAlpha’s
mission since its founding. The
educational outreach team inspires
and prepares the next generation
of scientists, while building
genomic literacy.

The dynamic team at HudsonAlpha reaches students, educators,
medical providers, patients and the community through
hands-on classroom modules, in-depth school and workshop
experiences and digital learning opportunities. Our
educational materials are used in every state in the United
States and in 19 countries. Last year, more than 1.5 million
individuals were impacted through Hudson A lpha’s
educational efforts.

Education for all

In the ever-changing world of biotech discovery,
HudsonAlpha is uniquely positioned to support any strategic
learning pathway. Co-located among accomplished
researchers and entrepreneurs, our expert educators have
access to cutting-edge discoveries that inspire them to
build exciting science experiences that can be implement-
ed anywhere. Visit lifescienceed.org to learn more about
bringing HudsonAlpha’s unique and inspiring programming
to your local community.

CtdoOevmDeEol:roWrpoomwrek’nsftobfirooctreech

In an effort to introduce undergraduate
students in Alabama to bioinformatics and
increase their access to authentic research
experiences, HudsonAlpha has developed
the CODE program – Characterizing Our
DNA Exceptions. Bioinformatics is a rapidly
growing field that applies computer science
and technology to biology and medicine. The
program is enrolling students from two- and
four-year colleges across Alabama.

AGgenriocmuilctsural

Farmers and foresters are
currently facing many serious
chalenges including increasing

scarcity of resources.
HudsonAlpha is addressing these
agricultural challenges by applying
genomic techniques to research

plants and agriculture.

To date, 50 percent of all the plants sequenced in the public domain have been completed by HudsonAlpha
scientists. Using new tools and HudsonAlpha’s extensive experience in plant genomics, HudsonAlpha scientists
are in a unique position to accelerate discoveries in crops and develop new scientific methods that will
change the way we grow and use plants in agriculture, forestry and other plant applications.

Saving the American chestnut tree Fpiontdeinntgiaalnoaflbtieorennaetrivgey:csrtuodpsying

More than a century ago, nearly four billion American Miscanthus is a type of grass sometimes cultivated as
chestnut trees were growing in the eastern United States. silvergrass in ornamental gardens. HudsonAlpha’s re-
The wood was hardy and used in furniture, fencing search, however, is focused on the agricultural applica-
and building. The nuts fed birds and animals. Un- tions of miscanthus as a source of biofuel. Scientists are
fortunately, a blight fungus killed them more than a field testing already developed hybrids that show promise
century ago. The chestnut blight has been called the for both cold tolerance and high yields. HudsonAlpha
greatest ecological disaster to strike the world’s forests. researchers are focusing their efforts on targeted traits
such as plant height or stem thickness to identify better
The HudsonAlpha Genome Sequencing Center has biofuel options.
just completed a reference genome for the American
We use genomic selection tools to identify and make
chestnut, giving researchers a decisions about targeted traits on a genome level without
way to analyze data that has having to grow mature plants. This process eliminates
been collected over time as the time-consuming process of traditional plant breed-
part of the breeding program ing, which relies largely on trial and error to select for
for chestnut trees. This, desirable traits like plant height or stem thickness.
along with the resequenc-
ing of hybrids from Amer- The interest in agricultural genomics is growing and
ican and Chinese chest- HudsonAlpha is poised to make a significant impact.
nuts, works toward the Our research team is expanding as well as our facilities.
ultimate aim of identifying Recently,HudsonAlphainstalled anew growth chamber,
the regions of the tree’s ge- which is a controlled growing environment. The hope is
nome that can protect it to increase our impact in the agricultural field and one
from the blight and restore day build a full operating greenhouse of our own.
the American chestnut tree
to forests in the United States.

Modern agriculture
and forestry produce
the food, fiber and
fuel that sustain
our lives.

We need to look at how to
improve the sustainability of our
crops now in order to make the
changes we need for the future.

We are just beginning to
understand the impacts of our
modern agriculture systems. We
need to find solutions that make
our crops more efficient – for both

food and biofuel sources.

- Jeremy schmutz
Faculty investigator

Lifetime Giving We would like to extend our deepest thanks to the following individuals,
to HudsonAlpha corporations and foundations for their extraordinary generosity. These members
have cumulative lifetime giving of $10,000+ in contributions and planned gifts.

chairman’s council Shirley and George McCrary Cindy and Ron Gray
Ginney and Foster McDonald Susan and Tom Griffith
$500,000 + The Peanut Foundation Jane Hays
Pei-Ling Chan Charitable Trust Peg and Buzz Heeschen
Alpha Foundation, Inc. Redstone Federal Credit Union Hexagon Intergraph
Anonymous Ruth and Foster Oliver HighTower Twickenham
CHDI Foundation Nancy and Ray Sheppard Andi and Steve Hill
Barbara and Tim Fisk Patsy and John Shields h2O4Christ Foundation Fund
Lynn and Jim Hudson Simons Foundation Jennie and Jimmy Hudson
Susan G. Komen Breast Sangeeta and Ashok Singhal Cynthia and Jim Hughes
Janice Smith Huntsville Hospital
Cancer Foundation Loretta Spencer Illumina, Inc.
Mike Loya St. Baldrick’s Foundation Intrepid
Helen and Lonnie McMillian Teledyne Brown Engineering, Inc. Carole and George Jones
Sue and Roy Nichols Jean Wessel Templeton Libby and Ray Jones
Pritzker Family Office, LLC Wayne, Luanne, and Peri Widener Keel Point, LLC
Eloise and Bill Propst Pennie and Tom Keene / The Keene
Emily and Steve Robertson Fund for the Study of
Clay Smith Neurodegenerative Diseases Group at UBS Financial
Linda J. Smith The Olin B. King Foundation
Sue McMillian Whitehead innovator Wally Kirkpatrick
Kord Technologies, Inc.
visionary $25,000 + Lanier Family Foundation
Lanier Ford
$100,000 + Cynthia and Rey Almodóvar Laura Crandall Brown Ovarian
American Association for
ADTRAN, Inc. Cancer Foundation
Alabama Power Foundation Cancer Research Terry and Herb Lewis
Pam and Joe Alexander American Cancer Society, Inc. Lightning Fund
The American Chestnut Foundation Anglin · Reichmann · Snellgrove & Lockheed Martin Corporation
Anonymous Betsy and Peter Lowe
Anonymous Armstrong, PC Lyndhurst Foundation
James Cecil and Margaret G. Nancy and Danny Archuleta Margaret and Hugh Mackie
Aviagen North America, Inc. Maynard Cooper & Gale, PC
Ashburn Foundation BBVA Compass Foundation Jean and Mac McCrady
The Boeing Company Ben May Charitable Trust Merrill Lynch Wealth Management
Bradley Arant Boult Cummings, Sheryl and Marc Bendickson Mike & Gillian Goodrich Foundation
Brasfield & Gorrie Elizabeth and Michael Morard/Qualis
LLP - Huntsville Traci and Steve Breland
Breast Cancer Research Burnett-Nickelson Family Fund Corporation
CFD Research Corporation Nancy Moss Family
Foundation of Alabama City of Huntsville, Alabama National ALS Foundation
Chris Brown Clearview Cancer Institute National Defense Industrial Association
Burger King - Wesfam Marie and P. Michael Cole Nektar Therapeutics
COLSA Corporation Kelli and Brian Pollock
Restaurants, Inc. Lyn and John Cook Pretium Valuation Group, LLC
James R. and Voncille J. Cleary Fund Bud Cramer Prevent Cancer Foundation
Crippled Children’s Foundation Mary Lee and Lee Prout
for Neurological Research Leta and Mike DeMaioribus Heather and Dale Qualls
Cotton, Inc. DESE Research, Inc. Regions Bank
Fred Craves Dimesol Nancy Rohr
The Daniel Foundation of Alabama Discovery Life Sciences Rosie’s Mexican Cantina
Estate of Tony DiCerbo Dynetics, Inc. Russel Hill Cancer Foundation
Estate of Nola and Frank J. Eiser Lue and Bill English Pat and Gene Sapp
GATR Technologies Yuliia and Mark Faist Amanda and Rob Seitz
iRepertoire Dick Fountain Serina Therapeutics, Inc.
Cindy and Richard Jackson Fuqua and Partners Architects, PC ServisFirst Bank
Ruth and John Jurenko Sarah and Carl Gessler Leslie and Pat Shields
Jane K. Lowe Charitable Betty and Bill Sims
S.S. Nesbitt & Company
Foundation
Mei Lu and Jian Han
Madison County Commission

Siniard-Partesotti Fund for Ona and John Hamilton
Psychiatric Research Dorcas Harris and Dick Reeves
Linda and Norm Harris
Solve ME/CFS Initiative iHeart Media
Synovus Bank IronMountain Solutions, Inc.
Susy and Bob Thurber Coy Jackson
Toyota Motor Manufacturing Jerry Damson Honda Acura
Kailos Genetics
Alabama, Inc. Liz and Jim Kennedy
Treasury Partners - David D’Amico Hope Kinch
Cynthia and Neil Lamb
and Richard Saperstein Alice and Frederick Lanier
Irma and Jack Tuder Longview Financial Advisors, Inc.
Nancy and Richard Van Valkenburgh / Kathy and Scott Ludwig
Scarlett and Brian Mathews
Van Valkenburgh & Wilkinson Realtors Christel and George McCanless
Vulcan Materials Company Foundation Nancy and Sam McManus
Wells Fargo The Mevatec Foundation
Christine and Mike Wicks Connie and Jerry Moore
Leslie and Danny Windham Randall Moreadith
Wendy Yang and Rick Myers National Bank of

sustainer Commerce
Northrop Grumman
$10,000 +
Corporation
3M Nucor Steel Decatur, LLC
Linda and Rob Akenhead Parkinson’s Support Group of
Alabama Media Group
Alfa Foundation Huntsville, Inc.
Alpha Tau Omega Fraternity-UAH Pearce Construction Company, Inc.
Anonymous Jean and Jerre Penney
Available Plastics, Inc. Progress Bank and Trust
Phylis and Bob Baron Renasant Bank
BBVA Compass Bank Catherine and Arthur Rollins
Alka Bhargav and Raj Khanijow Samples Properties, Inc.
Blue Cross and Blue Shield of Alabama Lucinda and Marshall Schreeder
C&A Printing, LLC Mrs. William Sims
Donna and Van Cancel Allison and Josh Solomon
The Caring Foundation of Blue Cross Connie and Rusty Stephenson
System Dynamics International, Inc.
and Blue Shield of Alabama System, Studies & Simulation, Inc.
Glynda Cavalcanti Thompson Gray, Inc.
Celsion-EGEN, Inc. Donna and Howard Thrailkill
Century Automotive TSA Seagate
City of Madison, Alabama Mike Turner
Corporate Dining Concepts Venturi, Inc.
Philip Crosby Gus Weisler
Cummings Aerospace Wells Fargo Foundation
Diatherix Laboratories, LLC Judy and Sidney White
Digium, Inc. Andy Whitehead
Kathleen and Phil Dotts
EBSCO Industries, Inc.
ERC Helping Hands
Mary and Emerson Fann
Nancy and Jerry Fishman
Ellen and Vincent Forlenza
Fraternal Order of Eagles Aerie 3263
Margaret and Jack Gleason
Glen Research Corporation
Google Fiber

Annual Giving In 2018, over 1,500 individuals, corporations and foundations supported HudsonAlpha with
their generosity. Gifts of all levels enabled us to continue building momentum, making incredible
progress in our mission. Donors who make annual gifts of $1,000 and above are included in the
Genome Circle, HudsonAlpha’s major giving program. All Genome Circle members are also
recognized for their generosity on the Giving Wall in the atrium of HudsonAlpha’s main building.

chairman’s council Lightning Fund The Olin B. King Foundation Jerry Bowling
Betsy and Peter Lowe Margaret and Hugh Mackie Kakki and J. R. Brooks
$500,000 + Madison County Commission Helen and Lonnie McMillian Kay Brotherton
Ben May Charitable Trust Merrill Lynch Wealth Elsie and Charlie Brown
Alpha Foundation, Inc. Nancy Moss Family Management Janet and David Brown
Anonymous National Defense Industrial Elizabeth and Michael Morard Martha and Mike Bryan
CHDI Foundation Association National Bank of Commerce Bryant Bank
Pritzker Family Office, LLC Redstone Federal Credit Nucor Steel Decatur, LLC Stacey Brewer
Eloise and Bill Propst Union Jean and Jerre Penney Charles Bryant
Linda J. Smith Russel Hill Cancer Foundation Mary Lee and Lee Prout Bubba’s Silver Spoon Catering
ServisFirst Bank Rosie’s Mexican Cantina Doris Burwell Foundation
visionary Patsy and John Shields Pat and Gene Sapp Rick Byrn
Betty and Bill Sims Lucinda and Marshall Ana and Jim Byrne
$100,000 + Siniard-Partesotti Fund for Schreeder C&A Printing, LLC
Psychiatric Research Thompson Gray, Inc. Joe Campbell
ADTRAN, Inc. Solve ME/CFS Initiative Nancy and Richard Van Canvas, Inc.
Alabama Power Foundation Synovus Bank Valkenburgh - Van Valken- Sherry and Winston Carroll
Anonymous Jean Wessel Templeton burgh & Wilkinson Properties Virginia and Michael Caruso
Anonymous Susy and Bob Thurber Vulcan Materials Company Angela Case
Pei-Ling Chan Charitable Trust Toyota Motor Manufacturing Foundation Celsion-EGEN, Inc.
Cotton, Inc. Alabama, Inc. Sue McMillian Whitehead Century Automotive
Shirley and George McCrary Irma and Jack Tuder Cepeda Systems & Software
Nancy and Ray Sheppard Valent Group benefactor Analysis, Inc.
Loretta Spencer Wells Fargo Alice Chenault and Milton Harris
Teledyne Brown Engineering, Inc. Christine and Mike Wicks $1,000 + Celeste and Tres Childs
Wayne, Luanne and Peri Widener Leslie and Danny Windham Ashley and John Clark
Fund for the Study of 4 Site, Inc. Clearview Cancer Institute
Neurodegenerative Disease sustainer Amber Brookman and Johanna Cleary
Devin Absher Voncille Cleary
innovator $10,000 + Leigh and John Adams Clinic for Women, P.A.
Advanced Life Clinic Marie and P. Michael Cole
$25,000 + 3M Linda and Rob Akenhead Elaine and Mitch Coley
Aviagen North America, Inc. Pam and Joe Alexander COLSA Corporation
Cynthia and Rey Almodóvar Bay City Capital Foundation Alliance Cancer Care Commercial Flooring Services, Inc.
American Association for BBVA Compass Foundation Alpha Tau Omega Fraternity-UAH Fay and John Copeland
Cancer Research Sheryl and Marc Bendickson Patricia Alred and John Hobdell Corporate Dining Concepts
American Cancer Society, Inc. Burnett-Nickelson Family Fund Anglin · Reichmann · Snellgrove Corporate Office Properties Trust
The American Chestnut Donna and Van Cancel & Armstrong, PC Crestwood Medical Center
Foundation The Caring Foundation of Anonymous Sara and Charlie Crocker
James Cecil and Margaret G. Blue Cross and Blue Shield Stephen Armstrong Paula Cushman
Ashburn Foundation Jenny and Tim Bachmann Margaret and David D’Amico
Bradley Arant Boult of Alabama Bankston Motor Homes Butch and Jerry Damson
Cummings, LLP City of Madison, Alabama Vicki and Paul Barber Karen and Manh Dang
Brasfield & Gorrie James R. and Voncille J. Amity and Rob Baron Data In Science Technologies
CFD Research Corporation Cleary Fund for Neurological Phylis and Bob Baron Davidson Technologies, Inc.
Crippled Children’s Research Margaret and Walter Batson Claudia and Jim Davis
Foundation Lyn and John Cook BB&T Bank and Home Loans Jan Davis and Dick Richardson
The Daniel Foundation Fred Craves Maudie and Roger Bedford deciBel Research, Inc.
of Alabama Cummings Aerospace Judy and David Berkowitz Edna and Jerry Deener
Leta and Mike DeMaioribus EBSCO Industries, Inc. Alka Bhargav and Raj Khanijow Dian Derrick
Dynetics, Inc. Fraternal Order of Eagles Bill Penney Toyota DESE Research, Inc.
Sarah and Carl Gessler Aerie 3263 Penny and Jay Billings Melissa and Eddie DeVore
Jennie and Jimmy Hudson Fuqua and Partners Blue Cross and Blue Shield Diatherix Laboratories, LLC
Intrepid Architects, PC of Alabama Estate of Tony DiCerbo
Cindy and Richard Jackson Margaret and Jack Gleason Tami and Jim Bolte Digium, Inc.
Carole and George Jones Google Fiber Boneal Aerospace Inc. Discovery Life Sciences
Pennie and Tom Keene / The Susan and Tom Griffith Braden Boone and Shawn Levy Martha Dolan
Keene Group at UBS Financial Peg and Buzz Heeschen BRAVO Cucina Italiana Kathleen and Phil Dotts
Lanier Family Foundation Hexagon Intergraph
Terry and Herb Lewis IronMountain Solutions, Inc.

Sharon Doviet and Chris Russell Kim and John Johnson Pearce Construction Treasury Partners - David
du Midi Johnson Partners, Inc. / Company, Inc. D’Amico and Richard Saperstein
Naomi DuBois McDonald’s Smitha and Tarek Persaud Caroyla and Patrick Tobbe
Dunagan Yates & Alison Andrea and Charles Jones Karen and David Petersen Troy 7, Inc.
Lucia and Sam Eidt Nancy and Tony Jones Enrico Poggio Kristen and George Twitty
Jency and John Eldridge Richele Jordan Davis and Lois and William Pope UAH College of Business
Janet and Derrel Emmerson Daryl Davis Pretium Valuation Group, LLC Administration
The Evers Family Foundation Kailos Genetics Progress Bank and Trust UAH College of Science
EyeCare Associates Huntsville West Caroline and Logan Kennedy Jeremy Prokop Uniti Fiber
FedEx Liz and Jim Kennedy Paige and Jeff Prozan Sally Upchurch
Barbara and Tim Fisk Hope Kinch Radiance Technologies, Inc. Lynne and Joe Vallely
Foresight Biosciences Shelbie King RCP Companies Venturi, Inc.
Dick Fountain Kord Technologies, Inc. Edgar Ready VWR
Harriet and Paul Frederick Vicki and Rich Kretzschmar Regions Bank Jane and William Walley
Eve and Owen Garriott Cynthia and Neil Lamb Joyce and Roger Rehfeld Warren Averett, LLC
Garver, LLC Landers McLarty of Huntsville Anne Marie and Tom Reidy Watermark at Bridge Street
Kathy and Steve Gilder Zelmira Lazarova and Jozef Renasant Bank Town Centre
Nancy and Gene Goldman Lazar Paula Renfroe Watson McKinney LLP
Goldman Sachs Leo Law Firm, LLC Lindsay and Bradley Rice Tina Watts
Cindy and Ron Gray Nita and Jim Lewis Jennifer Riggs-Sauthier and Wayne’s Acoustical and
Patsy and Paul Gray Lexus of Huntsville Marc Sauthier Drywall, Inc.
Sarah Green and Lynn Collyar Judy and Jim Link Nina and Terry Roberts Gus Weisler
Jane Grimwood and Lockheed Martin Corporation Emily and Steve Robertson Wells Fargo Foundation
Longview Financial Advisors, Inc. Ellen and Gig Robinson Juliet and Carter Wells
Jeremy Schmutz Michele and David Lucas Sonia Robinson Debbie and Larry West
Cindy and Gary Griner Cindi and Bob Ludwig Roche Kay and Don Wheeler
Clare and Mike Grisham Elaine and Frank Marsh Reba and Jim Rogers Marisa and Doug Wheelock
Marilyn and Walt Grundy Marshall Cancer Care Center Nancy Rohr Judy and Sidney White
Pat Hair Amy Mata Catherine and Arthur Rollins Lia and Ray White
Hall Albright Garrison Scarlett and Brian Mathews Patricia Ryan Diane Wick
and Associates Suzanne and Ben Matthews Saliba Family Luanne Widener
Ona and John Hamilton Bernadette and Duane Mayer Joe Salls Mary Williamson
Lori and Paul Handley Lisa and Todd McBride Salon Allure Wendy Wilson
Happy Hackers Christel and George McCanless Jean and Bill Salter April Windham and Matt Reed
Dorcas Harris and Dick Reeves Tricia McCoy and Steve Reed Timo Sandritter Mary and Newell Witherspoon
Natalie and Darrin Hasley Jean and Mac McCrady Rebecca and Thomas Womack & Associates, LLC
Jane Hays Martha and Hugh McInnish Satterfield Wendy Yang and Rick Myers
Bonnie and Steve Hettinger Becky and Jolly McKenzie Marie and Bill Schneider Mary Ruth Yates
HighTower Twickenham McLain Surgical Arts Jane Jackson Seltzer
Andi and Steve Hill Kelly and Robert McManus Serina Therapeutics, Inc. patron
Jane and Ken Hill Nancy and Sam McManus Donna and Bill Shergy
Hinson & Hinson, PC Penny and Plyler McManus Leslie and Pat Shields $500 +
h2O4Christ Foundation Fund Carol Meekins Beth and Dave Sippel
Chris and Bob Hinson Jessica Merritt Roger Smalligan Cynthia and Ted Achorn
Christy and Lee Hoekenschnieder Microarrays, Inc. SmartBank Carol Aiken
Jeremy Hon Ila Mitchum James Smelser Frances and Scott Akridge
Sandy and Bob Hovde Modern Technology Solutions, Inc. Liz Smith Candace Allen
Mary Shepard and Cutter Hughes Catherine and Ken Montgomery Rosalie Smith Anonymous
Marilyn and Dick Hull Ray Mooring Snelling Staffing Services Sylvia and Charles Betts
Huntsville Hospital Randall Moreadith Allison and Josh Solomon Ilsa and David Bick
Huntsville Hospital Clinic for Michele and Lance Morris Susan and Bill Sommers Madeline and John Boles
Breast Care Moss Lumber Industries, Inc. Lana Jo and Richard Spera Susan Borglum
Huntsville Hospital Corporate Liz and Jeff Murray SportsMED Orthopedic Surgery Beverly Boylan
Wellness Nesin Therapy Services & Spine Center Bridgeworth Financial
Huntsville ReproductiveMedicine North Alabama Chemical Liz Switzer Allison Brown
Iberia Bank Northrop Grumman System Dynamics Michael Butler
iCubate, Inc. Corporation International, Inc. Elizabeth Buzbee
iHeart Media Office Interiors by OSCO, System, Studies & Alice Campbell
Illumina, Inc. Inc. - Huntsville Simulation, Inc. Meagan and Nick Cochran
Imagehawk, Inc. Outpatient Diagnostic Center Carol and Jim Tevepaugh Sara and Greg Cooper
Innova Primary Care Robert Overall Norm and Kathi Tew Scott Couch
Karen and Paul Israel Susan Ozment Louann and Grant Thomson Ann and Morley Denbo
J. Smith Lanier & Co. Caroline Page Donna and Howard Thrailkill Dental Associates of Jones
Coy Jackson Parker Griffith Family Torch Technologies, Inc. Valley, LLC
Jerry Damson Honda Acura Foundation Margaret and Ricky Dockins
Chris and Bill Johnson

EngeniusMicro friend Joanne and Lou Horn Sharon and Ray Steelman
Nancy and Jerry Fishman Jodi Stephens
Foreign Language $250 + Jennifer Hutchison Steven H Deerman, CPA, Inc.
Services, Inc. InterFuze
James Gilbert A+ College Ready Christy and Jerry Jenkins Amanda Stokes
DeLynn Gower Mel Adams Cynthia and Eric Streams
Robbie and Bill Hallisey Debbie and Paul Agarwal Norma Jensen
Debra and Dean Hallmark All Women’s OBGYN Sarah Lauren and Andy Kattos Brett Sundlof
Joyce Hardin AmazonSmile Whitley Kelley Tactile Medical
Helen Harrand Cathy Anderson Shannon Talley
Samuel Havely Anonymous Tara and Jacob Kelly The Orthopaedic Center
Liz and Billy Herrin Barbara Anthony Wally Kirkpatrick
Katherine and Ed Hinson Pamela Baird Claudia Klus Brenda and Dick Titus
Meg and Herb Hocutt Jeanie and Doug Baker Elizabeth Vickery
Frances Huffman Dianne Barnett Barbara Lapidus Jenell Webber
Liz Hurley Hargrove and Eva and Barry Berman Brittany and Joshua Lasseigne
Dave Hargrove Kevin Bowling James Lawlor Nancy and Bruce Westfall
Leslie and John Jeffery Cindy and Steve Burcham Kelly Williams
Sydna and Bill Johnson Robbie Burlison LINE-X, LLC Liz Worthey and Michael McCool
Ann and James Ledbetter Calhoun Community College Ginger Loder
Angela Mack Cast Products, Inc. Linda and Don Maccubbin Ruth and Allen Yates
Maureen Mack and Sarah Chappell
Kenneth West Elizabeth and Francis Cline Shane Maddox
Nancy and Randy Martin Leigh and Andy Crouse Madison County Medical Alliance
Maynard Cooper & Gale, PC Crystal Mountain Water Sujan Mamidi Thank You
Lon McCormick Peggy and Larry Dill Linda and Carter Martin
Network For Good Nelly and Alberto Duarte Peggy McClure
Kim and Scott Newberry Kelly and Andrew East Genie and Bill McCoy
Linda and Jay Newkirk Aida El Kholi Starling Tara Mello
Carolyn and Clark Owen Peggy and Ray Fambrough Jo Ann and Robert Moorman for your generosity and
PeopleTec, Inc. Erin Fledderman James and Ann Moses support of HudsonAlpha.
Melanie Robinson Mike Frizzell
Peggy Sammon and Sharon and Jim Gardepe Nine Guys of Connestee Falls
Ralph Petroff Georgia Educational Sara Ogles
Remigius Shatas Technology Consortium, Inc. Sheela Parrish
Cathleen and Stephen Shaw Sunitha and Manmohan Bert Parsons
Ronda and Steve Shickles Ghanta Chris Partridge
Peg Skrenes Elise and Bill Goodson Catrina Paseur
Flo and John Stallworth Stacie Grelier Pam and Hal Paynter
Tammie Terry Mary and Jim Griffith PPT Solutions
Kimberly Tipton Elizabeth and Blake Herrin Melba and Everette Ramage
Sandra and Patrick Vallely Susan and Josh Hiatt Regina and Jon Randel
Valley Pizza, Inc. Barbara Paul and Tom Clyde Riley
Dana Watts Hickerson Ann Rivard
Irene and Mike Wisner Hiley Huntsville Diane Rivenburgh
Erin and James Robertson
Jane Rutenberg
Chris Sanders
Becky and Jim Schaaf
Susan Scott
David Shew
Nancy Siniard
St. Mark’s Evangelical Lutheran Church

The Double Helix Society refers to the DNA double helix, Anonymous Terry and Herb Lewis
the twisted double-stranded molecular structure that codes Pam and Joe Alexander Helen and Lonnie McMillian
all of life. DNA is the foundation of the dynamic research Johanna Cleary Sue and Roy Nichols
underway at HudsonAlpha as scientists strive to improve Voncille Cleary Ruth and Foster Oliver
human health and quality of life through genomic research, Paula Cushman Pat and Gene Sapp
economic development and educational outreach. Estate of Tony DiCerbo Nancy and Ray Sheppard
Sharon Doviet and Chris Russell Patsy and John Shields
Likewise, the Double Helix Society is the foundation of Estate of Nola and Frank J. Eiser Susan and Bill Sommers
HudsonAlpha’s future, ensuring a steady stream of charita- Jency and John Eldridge Charles Vaughn
ble revenue for years to come. These planned gifts perpet- Kathy and Steve Gilder August “Gus” Weisler
uate donors’ commitments to HudsonAlpha’s mission well Ona and John Hamilton Pamela Barratt White
into the future. Dorcas Harris Leslie and Danny Windham
Lynn and Jim Hudson Wendy Yang and Rick Myers
Carole and George Jones

InosftiDtuitreecBtoorasrd Connections
Michael Bertoldi Kevin Fernandez Ryan Letson Zach Sullivan
Will Best Brad Garland
Megan Breitbach Tiffany Gayman James Lomax George Twitty
Ray Brown Stephen Gunter
Jennifer Buckner Kelly Hamlin Markeeva Morgan Victor Vega
Caitlin Campbell Justin Johnson
Dana Cave Caroline Kennedy Charles Nelson Rob Warren
Hollie Collins Jonathan Lancaster
Jim Hudson, Gene Sapp Vincent Cooper Jason Landers Matthew Parker April Windham
chairman Linda J. Smith Lauren Dauro Nick Lasater
Irma Tuder Drew Davenport Megan Leach Taylor Propst Joey Yearta
Barbara Fisk John Wynn
Milton Harris Lonnie McMillian, Matt Reed
Sam McManus chairman emeritus
Brian Pollock Michelle Rudd
Bob Riley
Joe Salls

Katelyn Sides Baker

Mary Kate Sullivan

FouonfdDatiiroenctBorosard Professional Advisors Council
Liz Abel Brian Hinson Doug Martinson
Barbara Fisk, Foster McDonald Tom Albright Chris Hinson Todd McBride
chairman Bob Riley Gary Anglin Lee Hoekenschnieder Alex Pols
Emily Robertson Heather Baker Joy Howard Paula Renfroe
Marc Bendickson Chris Russell Alan Bibb Brittany Irons Chris Russell
Bobby Bradley Gary Saliba Jack Burwell John Jeffery Brandy Smith
Phil Dotts Linda J. Smith Joe Campbell Jeremy Jefferys Jessica Smith
Cindy Gray Jean Wessel Templeton Moss Crosby Mike Johnston Grant Thomson
Peter Lowe Sue Whitehead Stephannie Dattilo Brian Jones John Watts
David Lucas Daryl Davis Charles Jones Ray White
Dick Fountain Daryl Davis Greg Whitehead
Paul Frederick James Lancaster Mike Wisner
Ginger Harper David Little Lori Womack
Stephanie Hendon Scott Ludwig
Ambassadors
Linda Akenhead Karl Leo Physicians for HudsonAlpha
Pam Alexander Kim Lewis Dr. and Mrs. Rob Akenhead Dr. and Mrs. Robert Lancaster
Courtney Allen D.D. Martin Dr. Ray Armstrong Dr. and Mrs. Wayne Laney
Rose Allen Ben Matthews Drs. Aruna and Amit Arora Dr. Aimee League and Mr. Mark League
Cynthia Almodóvar Bob McCaleb Dr. Michael Butler Dr. and Mrs. Peter Loux
Dana Averbuch Shirley McCrary Dr. and Mrs. James Byrd Dr. and Mrs. Brian Mathews
Rob Baron Kevin McDaniel Drs. Ana and James Byrne Dr. Tricia McCoy and Mr. Steve Reed
Bobby Bradley Hal Mooty Dr. and Mrs. P. Michael Caruso Drs. Jo Ann and Robert Moorman
Ana Byrne Elizabeth Morard Dr. and Mrs. Tres Childs Dr. Randall Moreadith
Lynn Collyar Joe Newberry Dr. and Mrs. John Clark Dr. Sheela Parrish
Xan Curran Ron Poteat Dr. and Mrs. Manh Dang Dr. and Mrs. Brian Patz
Kerry Fehrenbach Mary Lee Prout Dr. and Mrs. Brett Davenport Dr. and Mrs. Robert Pendley
Margaret Gleason Paige Prozan Dr. Hayley DeGraaff and Mr. Chris Hutton Drs. Smitha and Tarek Persaud
Gene Goldman Ken Rivenbark Drs. Sharon and Jim Gardepe Drs. Anne Marie and Tom Reidy
Jeff Gronberg Jim Rogers Dr. and Mrs. Carl Gessler Dr. and Mrs. Bradley Rice
Dorcas Harris Chris Russell Dr. and Mrs. James Gilbert Dr. and Mrs. Bill Schneider
Jane Hays Nancy Sheppard Dr. and Mrs. Jack Gleason Dr. and Mrs. Marshall Schreeder
Liz Hurley Hargrove Pat Shields Dr. and Mrs. Bill Goodson Dr. and Mrs. Ray Sheppard
Debra Jenkins A.J. Singhal Dr. and Mrs. Paul Gray Dr. and Mrs. Bill Shergy
Andrea Jones Beth Sippel Dr. and Mrs. Parker Griffith Dr. Roger Smalligan
Carole Jones Jan Smith Dr. and Mrs. Tom Griffith Dr. and Mrs. Richard Spera
Tony Jones Norm Tew Dr. and Mrs. Walter Grundy Dr. and Mrs. Douglas Sutherland
Tracy Jones Bob Thurber Dr. and Mrs. John Hartley Dr. Brooke Uptagrafft and Mr. David Uptagrafft
Michelle Jordan Irma Tuder Dr. Jeremy Hon Dr. and Mrs. Don Wheeler
Andy Kattos Peri Widener Dr. and Mrs. Dick Hull Dr. and Mrs. Bruce Wingo
Pennie Keene Daniel Wilson Drs. Karen and Paul Israel Dr. Ruth Yates and Mr. Allen Yates
Robert Key Wendy Yang Dr. and Mrs. John Johnson
Wally Kirkpatrick Tom Young
Sherry Kolodziejczak In Loving Memory
Lonnie S. McMillian
July 27, 1928 - December 30, 2018

hudsonalpha.org/foundation