Authors Presenter
anseeuw | Jacobs | Schultz | Buckley | Properzi | Hanseeuw,
arrell | Scott | Hampton | Sanchez | Sperling | Johnson Bernard
ansson | Andersson | Janelidze | Ossenkoppele | Insel
trandberg | Zetterberg | Blennow | Chai | Dage | Hansson, Oskar
omrud | Smith | Palmqvist | Mattsson
arada | Lerdsirisuk | Yiqing | Ezura | Shimizu | Harada, Ryuichi
orito | Arai | Yanai | Kudo | Furumoto | Okamura
siao | Lin | Huang | Huang Hsiao, Ing-Tsung
ccarino | La Joie | Lesman-Segev | Soleimani-
eigooni | Provost | Collins | Aisen | Borowski |
oyan | Fagan | Foroud | Gatsonis | Jack Jr. | Kramer | Iaccarino,
aykin | Toga | Vemuri | Day | Graff-Radford | Honig | Leonardo
nes | Masdeu | Mendez | Onyike | Rogalski |
alloway | Wolk | Wingo | Koeppe | Dickerson |
postolova | Carrillo | Rabinovici
ccarino | La Joie | Edwards | Lesman-Segev | Strom | Iaccarino,
ham | Chaudhary | Fenton | Jerome | Janabi | Baker | Leonardo
iller | Jagust | Fagan | Rabinovici
ang | Ottoy | Savard | Pascoal | Mathotaarachchi | Kang, Min Su
enedet | Chamoun | Therriault | Lussier | Tissot |
homas | Stevenson | Rahmouni | Arias | Wang |
assarweh | Soucy | Gauthier | Rosa-Neto
ang | Ottoy | Chamoun | Mathotaarachchi | Savard | Kang, Min Su
enedet | Pascoal | Therriault | Lussier | Tissot |
homas | Stevenson | Rahmouni | Fernandez-Arias |
ang | Massarweh | Soucy | Gauthier | Rosa-Neto
m | Park | Park | Kang | Kim | Jang | Kim | Na | Lee | Kim, Jaeho
eo
ein | Sanabria | Leuzy | Borroni | Mattsson | Klein, Gregory
almqvist | Stomrud | Smith | Hansson
oran | Shams | Adams | Cazevedo | Toueg | Corso | Mormino,
unt | Castillo | Hall | Sha | Fredericks | Greicius | Elizabeth
agner | Zaharchuk | Davidzon | Chin | Mormino
enedet | J. Ashton | A. Pascoal | Stoops | Francois | Benedet, Andrea
anmechelen | K. Karikari | Mathotaarachchi | Savard
Therriault | Chamoun | Zetterberg | Blennow | Rosa-
eto
euzy | Smith | Ossenkoppele | Santillo | Borroni | Leuzy, Antoine
ein | Olsson | Jögi | Palmqvist | Mattsson |
randberg | Stomrud | Hansson
euzy | Klein | Ossenkoppele | Mattsson | Janelidze |
almqvist | Strandberg | Coloma | Borroni | Stomrud | Leuzy, Antoine
mith | Hansson
n | Hsiao | Huang | Huang Lin, Kun-Ju
anser | Sanabria Bohorquez | Teng | Baker | Toth | Manser, Paul
arik | Weimer
argolin | Lin | Tempest | Chen | Marek | Russell | Margolin,
andiego | Huang | Hsiao | Tamagnan | Alagille | Guan Richard
Lu | Zuo | Higuchi | Jang
ecca | Chen | Naganawa | Toyonaga | Godek | Harris
Bartlett | Zhao | Gallezot | Nabulsi | Huang | Arnsten | Mecca, Adam
arson | van Dyck
26
Board Poster Title
#
151 Mental and physical activity during the uptake period Mi
affects off-target binding in extra- and within-brain |B
Tau PET (18F-FTP)
Na
152 In vivo uptake of 18F-PM-PBB3 (18F-APN-1607) in Ta
patients with corticobasal syndrome |H
Zh
153 Factors predicting tau PET status in cognitively Os
unimpaired and impaired individuals Ma
Ha
Widespread amyloid is necessary to detect tau-PET
154 signal beyond the entorhinal crtex and cognitive Oz
decline
Using 18F-Flortaucipir visual assessment to define T- Pro
155 status in the AT(N) framework: evaluation of intra- Seg
and inter-rater reliability Jan
Defining T-status in the AT(N) framework: Pro
156 comparison of 18F-Flortaucipir visual assessment, Se
Ed
SUVR quantification and CSF pTau Jag
Plasma neurofilament light is associated with regional Qu
157 tau tangle burden in autosomal dominant AD: Ve
Findings from the COLBOS Project Ga
Application of tau PET as a biomarker of AD in Sal
158 therapeutic trials: A pharmaceutical industry Co
perspective
159 Measuring increases of tau pathology in AD using Sa
[18F]GTP1 (Genentech tau probe 1) PET imaging Ma
160 Evaluation of tau PET staging in the A4/LEARN San
study Ru
Re
161 Clinical evaluation o[18F]-JNJ-64326067, a candidate Sch
PET tracer for the detection of tau pathology in AD Ba
|K
Association between cerebrospinal fluid neurofilament
162 light chain and markers of neurofibrillary Sch
pathophysiology: Findings from the Knight Alzheimer Go
Disease Research Center
163 18F-PM-PBB3 (18F-APN-1607) uptake associates Sh
with plasma NfL level and motor disability in patients Ta
with progressive supranuclear palsy |N
Ka
164 The rate of accumulation of tau aggregates is higher in Sm
females and younger individuals Os
165 Resting state functional connectivity associations with Sv
F18-Florbetapir PET versus F18-Flortaucipir PET Ris
166 Tau positivity: Comparing flortaucipir meta-ROI vs Th
maximal single region Ka
167 Intrinsic connectivity of the human brain provides Th
scaffold for tau aggregation in AD Be
Ma
168 Changes in volumetric MRI measures at 12 months To
significantly correlate with baseline [18F]GTP1 Ma
SUVR, but not [18F]GTP1 change
Elevated medial temporal lobe Tau PET with 18F- To
169 PI2620 in normal controls with “borderline” Ha
Sh
neuropsychological testing profiles
170 Hippocampal tau accumulation predicts individual Tre
differences in episodic memory in cognitively normal Jay
older adults Da
|C
2
Authors Presenter
in | Apgar | Scott | Hol | Lundt | Albertson | Schwarz Min, Hoon-Ki
Botha | Vemuri | Gunter | Petersen | Jack | Lowe
akano | Shimada | Tagai | Matsuoka | Kubota |
akahata | Takado | Shinotoh | Yamamoto | Sano | Seki Nakano,
Hirano | Ono | Tempest | Jang | Sahara | Kawamura | Yoshikazu
hang | Kuwabara | Higuchi
ssenkoppele | Leuzy | Cho | La Joie | Strandberg | Ossenkoppele, Rik
atsson | Palmqvist | Lyoo | Rabinovici | Smith |
ansson
zlen | Binette | Köbe | Meyer | Villeneuve Ozlen, Hazal
ovost | Iaccarino | Soleimani-Meigooni | Lesman- Provost, Karine
egev | La Joie | Edwards | Strom | Pham | Mellinger | Provost, Karine
nabi | Baker | Jagust | Rabinovici Quiroz, Yakeel
ovost | Iaccarino | Soleimani-Meigooni | Lesman-
egev | La Joie | Mattsson | Hansson | Eichenlaub |
dwards | Strom | Pham | Mellinger | Janabi | Baker |
gust | Rabinovici
uiroz | Zetterberg | Reiman | Sanchez | Guzman-
elez | Fox-Fuller | Arboleda-Velasquez | Baena |
atchel | Sperling | Johnson | Blennow | Lopera
alinas | Lohith | Guo | Wooten | Tulip | Sanjeewa | Salinas, Cristian
omley | Sur | Hostetler | Beaver | Martarello
anabria Bohorquez | Baker | Manser | Toth | Teng | Sanabria
arik | Weimer Bohorquez,
Sandra
anchez | Becker | Jacobs | Hanseeuw | Mayblyum |
ubinstein | Thibault | Schultz | Seshadri | Quiroz | Sanchez, Justin
entz | Price | Sperling | Johnson | the A4 Study Team
chmidt | Janssens | Moechars | Rombouts | Timmers |
arret | Constantinescu | Madonia | Russell | Sandiego Schmidt, Mark
Kolb
chultz | Schindler | Chen | Sutphen | Morris | Fagan | Schultz, Stephanie
ordon | Benzinger
himada | Tagai | Tatebe | Matsuoka | Kubota |
akahata | Takado | Shinotoh | Yamamoto | Sano | Seki Shimada, Hitoshi
Nakano | Ono | Hirano | Tempest | Jang | Sahara |
awamura | Zhang | Tokuda | Higuchi
mith | Mattsson | Pontecorvo | Devous | Strandberg | Smith, Ruben
ssenkoppele | Hansson
valdi | Goñi | Stage | Abbas | Dzemidzic | West | Svaldi, Diana
sacher | Saykin | Apostolova
herneau | Schwarz | Wiste | Gunter | Senjem | Lowe | Therneau, Terry
antarci | Petersen | Knopman | Mielke | Jones | Jack
herriault | Pascoal | Savard | Mathotaarachchi | Therriault, Joseph
enedet | Chamoun | Gauthier | Saha-Chaudhuri |
assarweh | Rosa-Neto
oth | Sanabria Bohorquez | Manser | Baker | Teng | Toth, Balasz
arik | Weimer
oueg | Deutsch | Castillo | Hunt | Corso | Trelle |
arrison | Azevedo | Shen | Anders | Hall | Fredericks | Toueg, Tyler
ha | Davidzon | Chin | Khalighi | Wagner | Mormino
elle | Toueg | Castillo | Channappa | Corso | Hunt |
yakumar | Nadiadwala | Guo | Azevedo | Shin | Trelle, Alexandra
avidson | Deutsch | Hall | Sha | Fredericks | Kerchner
Carr | Chin | Wagner | Mormino
27
Board Poster Title
#
Temporo-limbic tau burden, as measured by 18F- Fis
Bu
171 AV1451, is a correlate of hippocampal volume loss
over time Wi
Be
172 Temporal evaluation for maximum CSF pTau181 – Wo
[18F]Flortaucipir concordance Tim
Bo
173 [18F]flortaucipir PET is more closely associated with Be
disease severity than CSF p-tau in AD
Sh
Associations of tau pathology and functional
174 connectivity with retrospective cognitive change
among cognitively normal older adults
2
Authors Presenter
scher | Ahnen | Dissertori | Lustermann | Weber | Unschuld, Paul
uck | Kagerer | Gietl | Hock | Unschuld
isch | Gordon | Schindler | Flores | Dincer | Fagan | Ances, Beau
enzinger | Morris | Ances Wolters, Emma
olters | Ossenkoppele | Verfaillie | Coomans |
mmers | Visser | Tuncel | Golla | Windhorst |
oellaard | van der Flier | Teunissen | Scheltens | van
erckel
hafer | Bilgel | Ziontz | Wong | Resnick Ziontz, Jacob
28
POSTER INDEX (by presente
Board Poster Title
#
100 Entorhinal tau pathology is associated with medial Ad
temporal lobe hyperactivity in aging Sta
120 Depression is predicted by tau imaging biomarker Ba
among cognitively normal adults Mo
53 Socioeconomic status mediates racial differences seen Wi
using the A-T(N) Framework Flo
172 Temporal evaluation for maximum CSF pTau181 – Wi
[18F]Flortaucipir concordance Be
01 Label-free x-ray method for estimating brain amyloid Ba
load
144 Cerebrospinal fluid tau phosphorylated at amino acid Be
181 or 231: a biomarker comparison in the detection of Va
neurofibrillary tangle pathology in the AD spectrum |T
Ne
02 Examining regional MK-6240 patterns and associations Be
with amyloid and cognitive decline Co
As
03 Transcriptomic profiling of brain amyloidosis using Bh
peripheral blood-based gene expression
121 Local associations between tau and neurodegeneration Bil
among non-demented older adults
04 A pons cluster detected by a data-driven approach may Bis
serve as a favorable reference region for 18F-PI-2620 Per
Tau PET analysis
122 Perfusion-phase 18F-PI-2620 tau-PET imaging as a Bre
surrogate marker of neuronal injury Ma
Ha
Ru
|M
|L
Vil
Bre
| Pa
Binding characteristics of 18F-PI-2620 differentiate the Ba
123 clinically predicted tau isoform in suspected 3/4-repeat Ru
and 4-repeat tauopathies Ma
Le
|D
124 18F-PI2620 tau-PET for assessment of heterogeneous Bre
neuropathology in corticobasal syndrome Hö
Ste
Eim
|L
80 Sex differences in the rates of cognitive decline Bu
associated with temporal lobe FTP-PET signal: findings Ha
from the Harvard Aging Brain Study
125 Optimal reference region for the quantification of tau Bu
load in the brain using 18F-PI-2620 PET San
05 Early detection of amyloid load using 18F-Florbetaben Bu
PET |T
De
Age-related neural dedifferentiation of episodic memory
06 networks is related to beta-amyloid and tau pathology in Ca
normal aging
126 Quantifying tau PET imaging reliably in the presence of Ch
off-target binding Flo
Mo
[18F]THK5317 imaging as a predictive tool of Ch
127 prospective cognitive decline in prodromal and An
dementia-stage AD
2
er’s last name)
Authors Presenter
dams | Maass | Berron | Harrison | Baker | Thomas | Adams, Jenna
anfill | Jagust Ances, Beau
Ances, Beau
abulal | Roe | Stout | Rajasekar | Wisch | Benzinger | Ances, Beau
orris | Ances
isch | Hudson | Coble | Xiong | Babulal | Gordon |
ores | Dincer | Benzinger | Morris | Ances
isch | Gordon | Schindler | Flores | Dincer | Fagan |
enzinger | Morris | Ances
adano | Dahal | Ghammraoui Badano, Aldo
enedet | J. Ashton | A. Pascoal | Stoops | Francois | Benedet, Andrea
anmechelen | K. Karikari | Mathotaarachchi | Savard
Therriault | Chamoun | Zetterberg | Blennow | Rosa-
eto
etthauser | Cody | Koscik | Jonaitis | Erickson |
onverse | Murali | Barnhart | Stone | Mueller | Clark | Betthauser, Tobey
sthana | Christian | Johnson
harthur Sanjay | Svaldi | Apostolova Bharthur Sanjay,
Apoorva
lgel | Wong | Resnick Bilgel, Murat
schof | van Eimeren | Koglin | Müller | Bullich | Bischof, Gerard
errotin | Stephens | Drzezga
endel | Beyer | Nitschmann | Barthel | van Eimeren |
arek | Song | Palleis | Respondek | Sauerbeck |
ammes | Barbe | Onur | Jessen | Saur | Schroeter |
umpf | Rullmann | Schildan | Patt | Neumaier | Barret Brendel, Matthias
Madonia | Russel | Stephens | Roeber | Herms | Bötzel
Levin | Classen | Hoeglinger | Bartenstein |
llemagne | Drzezga | Seibyl | Sabri
endel | Song | Beyer | Barthel | van Eimeren | Marek
alleis | Kaiser | Respondek | Sauerbeck | Hammes |
arbe | Onur | Jessen | Saur | Schroeter | Rumpf |
ullmann | Schildan | Patt | Neumaier | Barret | Brendel, Matthias
adonia | Russel | Stephens | Roeber | Herms | Bötzel |
evin | Classen | Hoeglinger | Bartenstein | Villemagne
Drzezga | Seibyl | Sabri
endel | Palleis | Prix | Gehmeyr | Bötzel | Danek |
öllerhage | Sauerbeck | Beyer | Nitschmann | Song |
ephens | Barthel | Patt | Sabri | Drzezga | van Brendel, Matthias
meren | Villemagne | Bartenstein | Perneczky | Haass
Levin | Hoeglinger
uckley | Properzi | Schultz | Jacobs | Kirn | Rentz | Buckley, Rachel
anseeuw | Johnson | Sperling
ullich | Müller | Roé-Vellvé | Jovalekic | Perrotin | De Bullich Roig,
anti | Koglin | Stephens Santiago
ullich | Roé-Vellvé | Marquié | Villemagne | Sanabria
Tartari | Sotolongo | Doré | Koglin | Müller | Perrotin | Bullich, Santiago
e Santi | Tárraga | Stephens | Rowe | Seibyl | Boada
assady | Adams | Maass | Harrison | Baker | Jagust Cassady, Kaitlin
hen | Gordon | McCullough | Zaza | Mejias | Dincer |
ores | Keefe | Paulick | Jackson | Koudelis | Su | Chen, Charles
orris | Benzinger
hiotis | Savitcheva | Poulakis | Saint-Aubert | Wall | Chiotis,
ntoni | Nordberg Konstantinos
29
Board Poster Title
#
Imaging synaptic and mitochondrial function in Cla
73 frontotemporal dementia using [11C]UCB-J, Sch
[18F]BCPP-EF and [11C]SA4503 PET Co
Cla
105 Longitudinal associations between lifestyle risk, β-
amyloid, and cognition in late-midlife
62 Correlation of QSM signal with Alzheimer’s Disease Co
biomarkers Kn
Ve
Pet
128 Comparison of quantitative cutoff methods for Mi
[18F]AV-1451 Aiz
Co
71 Quantitative regional amyloid burden and white matter Alv
changes in preclinical AD Be
con
Individual variability in the cortical distribution of
70 elevated 18F-AV1451 and 11C-PIB in a heterogeneous Co
sample of AD patients
07 Tau pathology and synaptic loss are closely associated Co
in Alzheimer’s disease in vivo: a combined Os
Sch
[18F]flortaucipir and [11C]UCB-J PET study Be
Longitudinal dynamic [18F]flortaucipir PET reveals Co
08 increased early stage tau pathology in individuals with Tim
subjective cognitive decline Wi
92 Amyloid deposition disrupts functional connectivity and Ing
graph properties within the default mode network Ko
Te
09 Preliminary evaluation of synaptic vesicle protein SV2A DiF
imaging with [11C]UCB-J across the cognitive En
spectrum
93 Neuroinflammation in AD patients and correlates with Ed
amyloid and tau deposition
85 Sex differences in regional tau deposition in cognitively Ed
impaired patients with Alzheimer’s disease Mi
69 Higher microglia biomarker levels are associated with Ew
slower rates of amyloid-beta accumulation in humans Blu
and in a transgenic mouse model of amyloid-beta
Early declines in learning and executive function Far
99 associated with accumulating Aβ not tau in low PIB Ha
adults
Fer
129 Pilot study on the relationship between 18F-MK-6240 Ka
and VBM in early and late stages of AD Tis
Ma
10 Quantifying off-target skull binding in [18F]Flortaucipir Flo
PET studies |H
Influence of iron and beta-amyloid deposition on
11 entorhinal cortex and hippocampal subfield volumes in Fo
the aging brain
130 Functional connectivity brain architecture predicts the Fra
rate of tau accumulation in AD Os
Association of tau tangle burden with depressive Ga
68 symptoms in community dwelling older adults: a Pro
Ch
longitudinal study Ha
78 Amyloid deposition affects the topography of cortical Ye
thinning in Lewy Body Disease Joh
13 Beta-amyloid deposition and its association with Go
metabolism Be
Amyloid binding is associated with markers of white Go
14 matter microstructure in patients with significant white Bo
matter disease La
3
Authors Presenter
arke | Mansur | Passchier | Lewis | Evans | Chen | Clarke, Mica
chwarz | Takano | Gunn | Cash | Rabiner | Rohrer
ody | Koscik | Birdsill | Berman | Erickson | Chin | Cody, Karly
ark | Christian | Betthauser | Johnson
ogswell | Wiste | Senjem | Therneau | Lowe | Cogswell, Petrice
nopman | Botha | Graff-Radford | Jones | Kantarci |
emuri | Ferman | Boeve | Mielke | Schwarz | Gunter |
etersen | Jack
inhas | Laymon | Lopresti | Snitz | Tudorascu | Cohen, Ann
zenstein | Lopez | Mathis | Klunk | Cohen
ollij | Top | Stickney | Ingala | Tomassen | Lopes Collij, Lyduine
ves | Yaqub | Wink | Van 't Ent | Scheltens | Van
erckel | Visser | Barkhof | Den Braber | AMYPAD
nsortium
ollins | Eckbo | McGinnis | Dickerson Collins, Jessica
oomans | Verfaillie | Wolters | Tuncel | Golla | Coomans, Emma
ssenkoppele | Scheper | Schober | Sweeney | Ryan |
chuit | Windhorst | Scheltens | Boellaard | van
erckel
oomans | Visser | Ossenkoppele | Verfaillie | Coomans, Emma
mmers | Wolters | Tuncel | Schmidt | Boellaard |
indhorst | Scheltens | van der Flier | van Berckel
gala | Wink | Prent | van 't Ent | Tomassen | ten Kate | den Braber,
onijnenberg | Collij | Yaqub | Scheltens | de Goes | Anouk
eunissen | Barkhof | van Berckel | Visser | den Braber
Filippo | Murali | McKinney | Davenport | Barnhart | DiFilippo,
ngle | Betthauser | Johnson | Bendlin | Christian Alexandra
dison | Leng | Dani | Brooks Edison, Paul
dwards | La Joie | Iaccarino | Kim | Baker | Casaletto | Edwards, Lauren
iller | Jagust | Rabinovici
wers | Brendel | Suarez-Calvet | Biechele | Sacher | Ewers, Michael
ume | Haass | Franzmeier
arrell | Papp | Buckley | Jacobs | Schultz | Properzi | Farrell, Michelle
anseeuw | Rentz | Johnson | Sperling
ernandez Arias | Pascoal | Benedet | Thierrault | Su Fernandez Arias,
ang | Savard | Ottoy | Mathotaarachchi | Lussier | Jaime
ssot | Thomas | Stevenson | Rahmouni | Wang |
assarweh | Soucy | Gauthier | Rosa-Neto
ores | Gordon | Su | Christensen | Dincer | Adedokun Flores, Shaney
Hornbeck | Morris | Benzinger
oster | Kennedy | Rodrigue Foster, Chris
anzmeier | Neitzel | Rubinski | Smith | Strandberg | Franzmeier,
ssenkoppele | Hansson | Ewers Nicolai
atchel | Marshall | Yang | Donovan | Buckley | Gatchel, Jennifer
operzi | Quiroz | Rabin | Vannini | Amariglio |
hhatwal | Rentz | Blacker | Sperling | Johnson |
anseeuw
e | Touroutoglou | Brickhouse | Katz | Growdon | Gomperts,
hnson | Dickerson | Gomperts Stephen
ordon | Goyal | Couture | Flores | Morris | Raichle | Gordon, Brian
enzinger | Vlassenko
oubran | Ozzoude | Adamo | Zukotynski | Bocti |
orrie | Chertkow | Frayne | Gao | Hsiung | Kiss | Goubran, Maged
aforce | Noseworthy | Prato | Ramirez | Sahlas | Scott
30
Board Poster Title
#
| Sm
So
107 Data-driven approach to characterization of tau Gr
accumulation in Braak staging groups Ap
How innocent is PART?: Mesial temporal tau is Gr
131 associated with worse cognitive performance in Aβ-
negative cognitively normal individuals
15 CSF dynamics explains discrepant PET-CSF AD Gu
biomarkers Ka
Jon
Jac
132 CSF P-tau detects cerebral tau accumulation earlier than Gu
tau PET in amyloid positive elderly adults
Hippocampal volume mediates the relationship between
20 amyloidosis and amyloid-sensitive cognitive composite Kim
in preclinical AD
77 A sensitive composite model to determine subtle Ha
cognitive differences in preclinical Alzheimer’s disease
Defining a Centiloid scale threshold predicting long-
61 term progression to dementia in patients attending the Ha
Memory Clinic: An F18-Flutemetamol amyloid-PET Bu
study
133 Amyloid, tau, and atrophy in preclinical AD: A Ha
longitudinal study Far
134 Increased levels and phosphorylation of soluble tau Ha
proteins occur earlier than changes in Tau PET in AD | St
Sto
135 Preclinical characterization of [18F]THK-5562, a novel Ha
tau PET tracer with little off-target binding Mo
17 [11C]PiB amyloid quantification and choice of He
reference region La
Comparison of tau PET imaging using 18F-APN-1607
136 and 18F-THK5351 in Alzheimer’s disease patients and Hs
normal controls
Retrospective prediction of amyloid accumulation Hw
18 trajectories in a risk-enriched Alzheimer’s disease Sin
cohort with sequential neural network
137 In vivo amyloid-PET and tau-PET evidence in early- Iac
onset AD: taking the LEADS Me
Elo
Sa
Jon
Sal
Ap
Multimodal in vivo investigation of amyloid and tau Iac
138 biomarkers associations with cerebrospinal fluid NfL Ph
Mi
and YKL40 levels
19 Data-driven biological pattern scoring of Flortaucipir Jon
scans outperforms ROIs Jos
Kn
139 Activated microglia and amyloid load potentiate tau Ka
deposition leading to cognitive dysfunction in AD Be
Th
Ma
Ka
140 Tauopathy in females is more vulnerable to amyloid or Be
neuroinflammation in AD Th
Wa
91 Prevalence of amyloid PET positivity in cognitively Kim
normal the East Asian populations
141 Prediction of brain tau accumulation in amyloid positive Kim
cognitive impairment patients using multimodal Seo
biomarkers with machine learning approach
3
Authors Presenter
mith | Sossi | Strother | Swartz | Tardif | Thiel | Groh, Jenna
oucy | Black
roh | Svaldi | Stage | Sanjay | Risacher | Saykin |
postolova
root Groot, Colin
unter | Senjem | Cogswell | Schwarz | Lowe | Gunter, Jeffrey
antarci | Vemuri | Elder | Botha | Graff-Radford |
nes | Mielke | Graff-Radford | Knopman | Petersen |
ck, Jr.
uo | Jagust | Landau Guo, Tengfei
m | Hahn | Kim | Kim | Chin | Seo Hahn, Alice
ahn | Kim | Kim | Jang | Kim | Na | Chin | Seo Hahn, Alice
anseeuw | Malotaux | Dricot | Quenon | Cerman | Hanseeuw,
uckley | Farrar | Ivanoiu | Lhommel Bernard
anseeuw | Jacobs | Schultz | Buckley | Properzi | Hanseeuw,
arrell | Scott | Hampton | Sanchez | Sperling | Johnson Bernard
ansson | Andersson | Janelidze | Ossenkoppele | Insel
trandberg | Zetterberg | Blennow | Chai | Dage | Hansson, Oskar
omrud | Smith | Palmqvist | Mattsson
arada | Lerdsirisuk | Yiqing | Ezura | Shimizu | Harada, Ryuichi
orito | Arai | Yanai | Kudo | Furumoto | Okamura
eeman | Hendriks | van Berckel | Lopes Alves | Heeman, Fiona
ammertsma | Yaqub
siao | Lin | Huang | Huang Hsiao, Ing-Tsung
wang | Koscik | Betthauser | Tao | Kim | Johnson | Hwang, Seong Jae
ngh
ccarino | La Joie | Lesman-Segev | Soleimani-
eigooni | Provost | Collins | Aisen | Borowski |
oyan | Fagan | Foroud | Gatsonis | Jack Jr. | Kramer | Iaccarino,
aykin | Toga | Vemuri | Day | Graff-Radford | Honig | Leonardo
nes | Masdeu | Mendez | Onyike | Rogalski |
alloway | Wolk | Wingo | Koeppe | Dickerson |
postolova | Carrillo | Rabinovici
ccarino | La Joie | Edwards | Lesman-Segev | Strom | Iaccarino,
ham | Chaudhary | Fenton | Jerome | Janabi | Baker | Leonardo
iller | Jagust | Fagan | Rabinovici
nes | Graff-Radford | Botha | Senjem | Wiste | Jones, David
sephs | Whitwell | Kantarci | Boeve | Petersen |
nopman | Lowe | Jack
ang | Ottoy | Savard | Pascoal | Mathotaarachchi | Kang, Min Su
enedet | Chamoun | Therriault | Lussier | Tissot |
homas | Stevenson | Rahmouni | Arias | Wang |
assarweh | Soucy | Gauthier | Rosa-Neto
ang | Ottoy | Chamoun | Mathotaarachchi | Savard | Kang, Min Su
enedet | Pascoal | Therriault | Lussier | Tissot |
homas | Stevenson | Rahmouni | Fernandez-Arias |
ang | Massarweh | Soucy | Gauthier | Rosa-Neto
m | Jung | Na | Kim | Won | Seo Kim, Jaeho
m | Park | Park | Kang | Kim | Jang | Kim | Na | Lee | Kim, Jaeho
eo
31
Board Poster Title
#
Kim
74 First-in-human evaluations of [11C]PS13 for imaging | Si
COX-1 and [11C]MC1 for imaging COX-2 Mo
Pik
21 Concordance of visual and quantitative assessments of Kle
baseline amyloid scans in the GRADUATE Ba
gantenerumab studies
142 Comparison of longitudinal change metrics for 18F- Kle
RO948 PET among cognitively unimpaired and patients Pal
with MCI or AD dementia in the BioFINDER2 study
64 Evaluating the relationships among odor identification, Kle
tau pathology and neuroinflammation in Alzheimer’s Ho
disease
22 Regional amyloid burden is associated with higher Ko
quantitative T1 in discrete hippocampal sub-regions |C
23 Genetically informed quantitative Gradient Recalled Ko
Echo MRI reveals brain tissue in hippocampal subfields Fag
void of neurons in mild Alzheimer's disease
24 Validation of highly sensitive and specific florbetaben La
positivity thresholds using ADNI participants and young Ko
controls
Voxel-wise relationships between white matter Ga
12 hyperintensities (WMH) and multimodal neuroimaging Go
biomarkers of Alzheimer’s disease La
25 Additive contribution of white matter hyperintensity to La
amyloid and neurodegeneration on cognitive decline in a Ste
diverse, community-based cohort of older adults
26 White matter hyperintensities are related to tau burden La
in late-Braak stage regions Lu
27 Probability template method for analysis of Down La
Syndrome amyloid PET Tu
67 Distinct effects of APOE ε2 on Aβ in Alzheimer- and Le
vascular-type cognitive impairment Os
Kim
28 Visualizing brain astrocytes - characterization of 3H- Le
BU99008 in human AD brain tissue
Diagnostic performance of [18F]RO948 tau positron Le
145 emission tomography in the differentiation of AD from Kle
other neurodegenerative disorders Str
146 Longitudinal changes in tau pathology measured by Le
[18F]RO948 tau-PET are associated with elevated CSF Pal
P-tau: Preliminary findings from the Swedish Sm
BioFINDER-2 study
Application of an epidemic spreading model to Le
29 characterize amyloid beta accumulation in autosomal
dominant Alzheimer’s disease mutation carriers
A comparison of ischemic stroke-induced changes on Lin
147 18F-APN-1607 (18F-PMPBB3) and 18F-THK-5351
uptake patterns
Phantom-based harmonization of PET image
30 reconstruction parameters between the Siemens ECAT Lo
HR+ PET and the GE Discovery MI PET/CT scanners
Longitudinal change in amyloid load over a 5-year Lu
79 period in cognitively healthy APOE4 carriers versus La
non-carriers: Effect of reference region
113 Mild behavioral impairment is associated with tau Lu
pathology in cognitively impaired elderly individuals |M
Ga
Modeling the trajectory of tau deposition in autosomal- Lu
114 dominant AD using the high-affinity tau tracer Ma
[18F]MK6240 Ne
101 Clinicopathological confirmation of 123I-FP-CIT Ma
SPECT (ioflupane) quantification methods in a Mi
3
Authors Presenter
m | Juarez Anaya | Lee | Hong | Miller | Telu | Morse
ingh | Cortes-Salva | Henry | Ruiz-Perdomo | Kim, Min-Jeong
ontero Santamaria | Liow | Zoghbi | Fujita | Katz |
ke | Innis
ein | Delmar | Voyle | Hesterman | Petrulli | Ovens | Klein, Gregory
audler | Fontoura | Doody | Kerchner
ein | Sanabria | Leuzy | Borroni | Mattsson | Klein, Gregory
almqvist | Stomrud | Smith | Hansson
ein | Yan | Johnson | Tomljanovic | Zou | Polly | Klein, Julia
onig | Brickman | Stern | Lee | Kreisl
ohli | Yang | Vogt | Asthana | Betthauser | Alexander Kohli, Akshay
Christian | Johnson | Kecskemeti | Bendlin
othapalli | Benzinger | Aschenbrenner | Goyal | Kothapalli, Satya
agan | Raichle | Morris | Yablonskiy V.V.N.
andau | Korman | Bullich | De Santi | Stephens | Landau, Susan
oeppe | Jagust
aubert | Lange | Garnier-Crussard | Bougacha | Lange, Catharina
onneaud | de Flores | Tomadesso | Mézenge |
andeau | de La Sayette | Chételat | Wirth
ao | Chesebro | Colon | Igwe | Gu | Schupf | Manly | Lao, Patrick
ern | Mayeux | Brickman
ao | Laing | Igwe | Chesebro | Kreisl | Moreno | Lao, Patrick
uchsinger | Brickman Laymon, Charles
Lee, Jin San
aymon | Minhas | James | Christian | Cohen | Klunk |
udorascu | Royse | Zaman | Handen
ee | Lee | Park | Choe | Park | Cheon | Hahn |
ssenkoppele | Kim | Kim | Yoo | Jang | Cho | Kim |
m | Jung | Park | DeCarli | Weiner | Yun | Na | Seo
emoine | Malarte | Koistinen | Nordberg Lemoine, Laetitia
euzy | Smith | Ossenkoppele | Santillo | Borroni | Leuzy, Antoine
ein | Olsson | Jögi | Palmqvist | Mattsson |
randberg | Stomrud | Hansson
euzy | Klein | Ossenkoppele | Mattsson | Janelidze |
almqvist | Strandberg | Coloma | Borroni | Stomrud | Leuzy, Antoine
mith | Hansson
evitis | Vogel | Kiar | Funck | Iturria-Medina | Evans Levitis, Elizabeth
n | Hsiao | Huang | Huang Lin, Kun-Ju
ois | Grogg | El Fakri | Johnson | Price Lois, Cristina
uckett | Adamczuk | Schaeverbeke | Gabel | Van Luckett, Emma
aere | Dupont | Vandenberghe
ussier | Pascoal | Therriault | Tissot | Savard | Benedet
Mathotaarachchi | Stevenson | Ismail | Rosa-Neto | Lussier, Firoza
authier
ussier | Therriault | Pascoal | Savard |
athotaarachchi | Robb | Stevenson | Gauthier | Rosa- Lussier, Firoza
eto
altais | Jordan | Miyagawa | Lesnick | Przybelski | Maltais, Daniela
in | Dickson | Murray | Kantarci | Boeve | Lowe
32
Board Poster Title
#
spectrum of neurodegenerative syndromes and
associated pathologies
38 Amyloid PET variability due to variation in MRI Pal
protocol and anatomical segmentation
39 The impact of automatic Tau PET processing on uptake Pal
variability and power analysis in AD
148 Longitudinal change in [18F]GTP1 SUVR over 18 Ma
months depends on baseline SUVR intensity and spatial Ma
distribution and shows trends with cognitive decline
149 18F-APN-1607: a promising PET tracer for multiple Ma
tauopathies San
|L
31 Age prediction and amyloid deposition in SuperAgers Ma
Par
106 Exploring relationships between tau burden and naming Ma
in the aphasic variant of AD Me
32 PiB tracer delivery decreases overtime in preclinical AD Ma
– impact for amyloid pathology measurement Ru
Joh
65 Elevated soluble phosphorylated tau is a marker of early Be
amyloid PiB PET abnormalities and accumulation Fag
A clinically-relevant scheme for qualitatively rating tau
112 PET, amyloid PET, and MRI in neurodegenerative Mc
cognitive presentations
Entorhinal cortical tau accumulation is inversely Me
150 associated with hippocampal synaptic density in older |B
Ca
individuals with normal cognition and early AD
66 Cerebrospinal fluid and PET measures of tau pathology Me
may indicate different stages of AD pathological Vil
progression
Use of the plasma amyloid-beta 42/40 ratio for Mi
96 predicting amyloid PET in a community-based Kn
population
151 Mental and physical activity during the uptake period Mi
affects off-target binding in extra- and within-brain Tau |B
PET (18F-FTP)
34 Sex-specific differences in [18F]AV-1451 off-target Mi
retention Aiz
35 Polygenic risk for Cerebrospinal Fluid (CSF) amyloid Mo
predicts brain amyloid in clinically normal older adults Ma
Cerebrospinal fluid matrix metalloproteinases are
111 associated with compromised white matter Mo
microstructure among older adults: the Vanderbilt |B
memory & aging project
143 Validation of clinical protocols for clinicians analyzing Ko
18F-PI-2620 tau PET/MRI images Hu
Wa
152 In vivo uptake of 18F-PM-PBB3 (18F-APN-1607) in Na
patients with corticobasal syndrome Ta
|H
Zh
94 Development of new alpha7 nicotinic receptor ASEM No
analogs for PET imaging Mi
Lå
36 Association between cerebral amyloid accumulation and OD
synaptic density in Alzheimer’s disease: A multitracer Ba
Na
PET study Ca
108 Associations between AD biomarkers and cognition Oh
among cognitively normal older adults
153 Factors predicting tau PET status in cognitively Os
unimpaired and impaired individuals Ma
Ha
3
Authors Presenter
alombit | Manber | Joules | Wolz Manber, Richard
alombit | Manber | Joules | Wolz Manber, Richard
anser | Sanabria Bohorquez | Teng | Baker | Toth | Manser, Paul
arik | Weimer
argolin | Lin | Tempest | Chen | Marek | Russell | Margolin,
andiego | Huang | Hsiao | Tamagnan | Alagille | Guan Richard
Lu | Zuo | Higuchi | Jang
artersteck | Besson | Sridhar | Makowski-Woidan | Martersteck,
arrish | Katsaggelos | Mesulam | Bandt | Rogalski Adam
artersteck | Sridhar | Coventry | Eldes | Wood | Kim | Martersteck,
esulam | Rogalski Adam
ayblyum | Becker | Schultz | Farrell | Jacobs | Mayblyum,
ubinstein | Sanchez | Thibault | Sperling | Price | Danielle
hnson | Hanseeuw
enzinger | Benzinger | Joseph-Mathurin | Benzinger | McDade, Eric
agan | Xiong | Barthélemy | Bateman
cGinnis | Collins | Eckbo | Brickhouse | Dickerson McGinnis, Scott
ecca | Chen | Naganawa | Toyonaga | Godek | Harris
Bartlett | Zhao | Gallezot | Nabulsi | Huang | Arnsten | Mecca, Adam
arson | van Dyck
eyer | Pichet Binette | Gonneaud | Breitner | Meyer, Pierre-
lleneuve Francois
ielke | Algeciras-Schimnich | Campbell | Syrjanen | Mielke, Michelle
nopman | Jack Jr. | Peterson
in | Apgar | Scott | Hol | Lundt | Albertson | Schwarz Min, Hoon-Ki
Botha | Vemuri | Gunter | Petersen | Jack | Lowe
inhas | Yu | Laymon | Lopresti | Snitz | Tudorascu | Minhas, Davneet
zenstein | Lopez | Mathis | Klunk | Cohen Moore, Annah
oore | Dumitrescu | Schultz | Raghavan | Johnson |
ayeux | Sperling | Hohman | Mormino
oore | Pechman | Acosta | Bell | Anderson | Landman Moore, Elizabeth
Blennow | Zetterberg | Gifford | Hohman | Jefferson
oran | Shams | Adams | Cazevedo | Toueg | Corso | Mormino,
unt | Castillo | Hall | Sha | Fredericks | Greicius | Elizabeth
agner | Zaharchuk | Davidzon | Chin | Mormino
akano | Shimada | Tagai | Matsuoka | Kubota |
akahata | Takado | Shinotoh | Yamamoto | Sano | Seki Nakano,
Hirano | Ono | Tempest | Jang | Sahara | Kawamura | Yoshikazu
hang | Kuwabara | Higuchi
ordberg | Lemoine | Mohan | Kuang | Nag | Jia |
iranda Azpiazu | Datta | Arakawa | Varnäs | Ågren | Nordberg, Agneta
ångström | Halldin
Dell | Mecca | Chen | Godek | Harris | Bartlett | O’Dell, Ryan
anks | Kominek | Zhao | Naganawa | Toyonaga | Lu |
abulsi | Vander Wyk | Varma | Arnsten | Huang |
arson | van Dyck
h | Correia | Salloway Oh, Hwamee
ssenkoppele | Leuzy | Cho | La Joie | Strandberg | Ossenkoppele, Rik
atsson | Palmqvist | Lyoo | Rabinovici | Smith |
ansson
33
Board Poster Title
#
A clinically applicable proxy for gold standard Ott
37 quantification of amyloid-beta in Alzheimer’s disease: Hs
Bolus plus constant infusion 18F-AV45 PET | So
154 Widespread amyloid is necessary to detect tau-PET Oz
signal beyond the entorhinal crtex and cognitive decline
[11C]MK-6884 PET tracer for M4 muscarinic Pas
75 cholinergic receptors in AD: Comparison with Wa
Ma
[18F]FDG PET
81 Amyloid and tau PET burden are associated with white Pic
matter bundle abnormalities in asymptomatic De
individuals at risk of AD
Using 18F-Flortaucipir visual assessment to define T- Pro
155 status in the AT(N) framework: evaluation of intra- and Seg
inter-rater reliability Jan
156 Defining T-status in the AT(N) framework: comparison Pro
of 18F-Flortaucipir visual assessment, SUVR Seg
quantification and CSF pTau Ed
Jag
Plasma neurofilament light is associated with regional Qu
157 tau tangle burden in autosomal dominant AD: Findings Ve
from the COLBOS Project Ga
MIND MAPS: Assessment of the mitochondrial - Ra
Pag
40 endoplasmic reticulum - synaptic axis in Mi
neurodegeneration by [18F]BCPP-EF, [11C]SA4503 Ma
Pas
and [11C]UCB-J PET imaging
Ra
41 Associations between Neurogranin and imaging Kv
biomarkers of Alzheimer’s disease Ste
Ga
42 Linking APOE ε4, blood-brain barrier dysfunction and Rip
inflammation to Alzheimer’s pathology Ve
Increased risk of AD in alcohol use disorder is not Ro
104 mediated by amyloid-beta in a middle-aged cross- Na
sectional cohort
43 Heterogeneity of tau PET signal in the sub-nuclei of the Ru
amygdala Ma
Go
Cross-sectional and longitudinal non-dichotomized
86 CSF/PET Aβ data support existence of “CSF+ first” vs. Sal
“PET+ first” pathways of Aβ biomarkers changes
158 Application of tau PET as a biomarker of AD in Sal
therapeutic trials: A pharmaceutical industry perspective Co
82 NeuroToolkit CSF biomarkers track the progression of Sal
AD at very early stages and show that inflammatory Ze
markers modulate cerebral amyloid accumulation Far
Su
Fal
83 T1rho MRI measurement of amyloid plaque burden in Pu
cognitively unimpaired individuals: preliminary results Fer
in the ALFA+ cohort Ro
Mi
Gis
84 Preliminary quantitative results of the AMYPAD Gis
prognostic and natural history study He
Ve
| th
159 Measuring increases of tau pathology in AD using San
[18F]GTP1 (Genentech tau probe 1) PET imaging Ma
San
160 Evaluation of tau PET staging in the A4/LEARN study Ru
Re
3
Authors Presenter
toy | Kang | Verhaeghe | Stroobants | Bouhachi |
siao | Stevenson | Rahmouni | Chartrand | Massarweh Ottoy, Julie
oucy | Gauthier | Rosa-Neto | Staelens
zlen | Binette | Köbe | Meyer | Villeneuve Ozlen, Hazal
ascual | Zanotti-Fregonara | Yu | Funk | Arbones | Pascual, Belen
ang | Li | Cheng | Anderson | Hostetler | Basile |
asdeu
chet Binette | Theaud | Gonneaud | Poirier | Pichet Binette,
escoteaux | Villeneuve Alexa
ovost | Iaccarino | Soleimani-Meigooni | Lesman- Provost, Karine
egev | La Joie | Edwards | Strom | Pham | Mellinger | Provost, Karine
nabi | Baker | Jagust | Rabinovici Quiroz, Yakeel
ovost | Iaccarino | Soleimani-Meigooni | Lesman- Rabiner, Eugenii
egev | La Joie | Mattsson | Hansson | Eichenlaub |
dwards | Strom | Pham | Mellinger | Janabi | Baker | Rahmouni,
gust | Rabinovici Nesrine
Riphagen, Joost
uiroz | Zetterberg | Reiman | Sanchez | Guzman-
elez | Fox-Fuller | Arboleda-Velasquez | Baena |
atchel | Sperling | Johnson | Blennow | Lopera
abiner | Mansur | Venkataraman | Price | Wilson |
agano | Clarke | Lewis | Matthews | Rowe | Brooks |
iddleton | Politis | Rohrer | Comley | Evans |
artarello | Chen | Schwarz | Schmidt | Tsukada |
asschier | Gunn | Consortium
ahmouni | Benedet | Nicholas | Tissot | Pascoal |
vartsberg | Chamoun | Kang | Lussier | Therriault |
evenson | Savard | Mathotaarachchi | Thomas |
authier | Zetterberg | Blennow | Rosa-Neto
phagen | Ramakers | Freeze | Pagen | Hanseeuw |
erbeek | Verhey | Jacobs
oyse | Himes | Minhas | Lopresti | Flanigan | Royse, Sarah
arendran
ubinstein | Jacobs | Augustinack | Properzi | Becker |
ayblyum | Thibault | Sanchez | Schultz | Hanseeuw | Rubinstein, Zoe
omez-Isla | Lois-Gomez | Price | Sperling | Johnson
ala | Nordberg | Rodriguez-Vieitez Sala, Arianna
alinas | Lohith | Guo | Wooten | Tulip | Sanjeewa | Salinas, Cristian
omley | Sur | Hostetler | Beaver | Martarello
alvadó | Molinuevo | Milà-Alomà | Blennow |
etterberg | Operto | Falcón | Batrla | Battle | Buckley | Salvadó, Gemma
arrar | Minguillon | Fauria | Sánchez-Benavides |
uárez-Calvet | Gispert | the ALFA study
alcón | Montesinos | Grau-Rivera | Suárez-Calvet | Salvadó, Gemma
uig-Pijoan | Cascales | Navalpotro-Gomez |
ernández-Lebrero | Sánchez-Valle | Gelpi | Sanfeliu |
ojas | Perissinotti | Niñerola-Baizán | Salvadó |
inguillon | Fauria | Molinuevo | Sánchez-González |
spert | the ALFA study
spert | Lopes-Alves | Gray | Buckley | Collij | Salvadó, Gemma
eeman | Salvadó | Scheltens | Frisoni | Ritchie |
ellas | Stephens | Ford | Molinuevo | Farrar | Barkhof
he AMYPAD Consortium
anabria Bohorquez | Baker | Manser | Toth | Teng | Sanabria
arik | Weimer Bohorquez,
Sandra
anchez | Becker | Jacobs | Hanseeuw | Mayblyum |
ubinstein | Thibault | Schultz | Seshadri | Quiroz | Sanchez, Justin
entz | Price | Sperling | Johnson | the A4 Study Team
34
Board Poster Title
#
72 Effect of genetic risk, brain amyloid and hippocampal Sch
volume on normal variation in episodic memory Du
performance in middle-aged and older adults
161 Clinical evaluation o[18F]-JNJ-64326067, a candidate Sch
PET tracer for the detection of tau pathology in AD Ba
|K
Association between cerebrospinal fluid neurofilament
162 light chain and markers of neurofibrillary Sch
pathophysiology: Findings from the Knight Alzheimer Go
Disease Research Center
44 MCI patients demonstrate reliably increasing 18F- Sco
AV1451 PET uptake across three exams
White matter disruption is an early and progressive Sco
103 feature of pre-symptomatic Dutch-type hereditary |B
Ch
cerebral amyloid angiopathy
Development of a qualitative read method for Sei
45 characterizing the presence and extent of brain tau Ma
deposition using [18F]MK-6240 PET imaging
Head-to-head comparison of F-Florbetaben and F-
88 Flutemetamol uptakes in the cortex, striatum and white Seo
matter
163 18F-PM-PBB3 (18F-APN-1607) uptake associates with Sh
plasma NfL level and motor disability in patients with Ta
progressive supranuclear palsy |N
Ka
16 Predicting future amyloid spread with machine learning Ha
using longitudinal [C11]PiB-PET in preclinical Ch
Alzheimer's disease
164 The rate of accumulation of tau aggregates is higher in Sm
females and younger individuals Os
46 PET imaging of [11C]MPC-6827, a microtoubule-based So
PET tracer in murine models of AD
47 Quantifying the relationship between the brain So
distributions of tau and local atrophy to inter-regional Ka
connectivity based on individual human data
PI-2620 Tau PET is associated with amyloid-beta levels Ste
90 in scans from subjects of the elenbecestat MissionAD Ad
program Alb
48 Monitoring disease pathophysiology using Ste
multiparametric PET acquisitions: The McGill TRIAD Ma
Cohort |L
Sb
165 Resting state functional connectivity associations with Sv
F18-Florbetapir PET versus F18-Flortaucipir PET Ris
110 Using famous faces to investigate the neural systems Te
involved in name retrieval
109 In vivo association of mitochondrial dysfunction with Te
tau pathology in early AD Ne
166 Tau positivity: Comparing flortaucipir meta-ROI vs Th
maximal single region Ka
167 Intrinsic connectivity of the human brain provides Th
scaffold for tau aggregation in AD Be
Ma
Preliminary results: PiB and MK6240 regional PET Ma
102 measures associated with digitized clock drawing |R
Joh
performance
49 Interaction between amyloid and neuroinflammation on Tis
apathy along the Alzheimer’s disease spectrum Ch
Ma
50 Neuropsychiatric symptoms in cognitively impaired Tis
individuals are correlated with tau deposition Sav
Ne
3
Authors Presenter
chaeverbeke | Gabel | Adamczuk | Van Laere | Schaeverbeke,
upont | Vandenberghe Jolien
chmidt | Janssens | Moechars | Rombouts | Timmers |
arret | Constantinescu | Madonia | Russell | Sandiego Schmidt, Mark
Kolb
chultz | Schindler | Chen | Sutphen | Morris | Fagan | Schultz, Stephanie
ordon | Benzinger
cott | Adamczuk | Gorman | Runkle | Suhy Scott, David
cott | Schultz | Sohrabi | Gardener | Taddei | Bateman
Benzinger | Johnson | Sperling | Martins | Greenberg | Scott, Matthew
hhatwal | Investigators
eibyl | Salinas | Rajagovindan | Hutchison | Beaver | Seibyl, John
artarello
eo | Cho | Moon | Choe | Na Seo, Sang Won
himada | Tagai | Tatebe | Matsuoka | Kubota |
akahata | Takado | Shinotoh | Yamamoto | Sano | Seki Shimada, Hitoshi
Nakano | Ono | Hirano | Tempest | Jang | Sahara |
awamura | Zhang | Tokuda | Higuchi
ao | Vogt | Meng | Hwang | Koscik | Betthauser | Singh, Vikas
hristian | Johnson | Bendlin | Singh
mith | Mattsson | Pontecorvo | Devous | Strandberg | Smith, Ruben
ssenkoppele | Hansson
olingapuram sai | Macauley | Whitlow | Mintz | Craft Solingapuram Sai,
Kiran Kumar
oucy | Mohammadi | Rosa-Neto | Pascoal | Savard | Soucy, Jean-Paul
ang | Therriault | Benali
ephens | Bullich | Mueller | Berndt | De Santi | Scott |
damczuk | Suhy | Kaplow | Giroux | Krause | Chang | Stephens, Andrew
bala
evenson | Chamoun | Pascoal | Benedet | Kang |
athotaarachchi | Therriault | Thomas | Savard | Tissot Stevenson, Jenna
Lussier | Vinet-Celluci | Rahmouni | Gagné | Joung |
beiti | Shin | Vitali | Gauthier | Rosa-Neto
valdi | Goñi | Stage | Abbas | Dzemidzic | West | Svaldi, Diana
sacher | Saykin | Apostolova
ennant | Jagust | La Joie | Adams | Winer Tennant, Victoria
erada | Therriault | Min Su | Savard | Ouchi | Rosa- Terada, Tatsuhiro
eto
herneau | Schwarz | Wiste | Gunter | Senjem | Lowe | Therneau, Terry
antarci | Petersen | Knopman | Mielke | Jones | Jack
herriault | Pascoal | Savard | Mathotaarachchi | Therriault, Joseph
enedet | Chamoun | Gauthier | Saha-Chaudhuri |
assarweh | Rosa-Neto
ayblyum | Thibault | Moody | Farrell | Jiang | Jacobs
Rubinstein | Sanchez | Katz | Sperling | Papp | Rentz | Thibault, Emma
hnson
ssot | Kang | Benedet | Rahmouni | Pascoal | Tissot, Cécile
hamoun | Therriault | Lussier | Savard |
athotaarachchi | Thomas | Gauthier | Rosa-Neto
ssot | Therriault | Pascoal | Chamoun | Lussier | Tissot, Cécile
avard | Mathotaarachchi | Benedet | Thomas | Rosa-
eto | Gauthier
35
Board Poster Title
#
168 Changes in volumetric MRI measures at 12 months To
significantly correlate with baseline [18F]GTP1 SUVR, Ma
but not [18F]GTP1 change
Elevated medial temporal lobe Tau PET with 18F- To
169 PI2620 in normal controls with “borderline” Ha
Sh
neuropsychological testing profiles
Hippocampal tau accumulation predicts individual Tre
170 differences in episodic memory in cognitively normal Jay
Da
older adults |C
33 MRI and PET data harmonization in a two-site Down Mi
syndrome study | Jo
Ch
97 Associations between longitudinal cognitive measures Tu
and cross-sectional tau in adults with Down syndrome Ell
Ch
171 Temporo-limbic tau burden, as measured by 18F- Fis
AV1451, is a correlate of hippocampal volume loss over Bu
time
60 Longitudinal flortaucipir ([18F]AV-1451) PET uptake Uti
in Semantic Dementia Cla
Jr.
76 Assessing Aβ, tau, and reactive astrocytosis in aging and Vil
AD Ku
Vo
Developing a novel alpha-synuclein (a-syn) positron Jür
63 emission tomography (PET) tracer for the diagnosis of Da
Parkinson’s disease (PD) and other a-synucleinopathies Hli
Vil
51 Association between [18F]NAV4694 PET amyloid-β Wa
measures and fluid biomarkers across the spectrum of |K
Alzheimer's disease
PET beta-amyloid deposition in healthy older adults is
52 associated with decreased lure discrimination on a We
spatial mnemonic similarity task
95 Biological underpinnings of typical and atypical Wh
Alzheimer’s dementia phenotypes Sch
Kn
89 Sleep impairment predicts longitudinal accumulation of Wi
β-amyloid
Tau pathology and relative cerebral blood flow are Wo
54 independently associated with cognition in Alzheimer’s Tu
disease Fli
173 [18F]flortaucipir PET is more closely associated with Wo
disease severity than CSF p-tau in AD Tim
Bo
Be
87 Personality and amyloid accumulation in cognitively Yo
normal aging
55 Amyloid Load trajectories and chronicity reveal groups Za
of early amyloid accumulators in Down syndrome Co
Ha
56 Hippocampal-retrosplenial cortex connectivity predicts Zio
tau accumulation in cognitively normal older adults
Associations of tau pathology and functional
174 connectivity with retrospective cognitive change among Sh
cognitively normal older adults
Associations of amyloid deposition and FDG uptake in Zu
98 aging and cognitively impaired elders with and without Bo
moderate to severe periventricular white matter No
hyperintensities So
3
Authors Presenter
oth | Sanabria Bohorquez | Manser | Baker | Teng | Toth, Balasz
arik | Weimer
oueg | Deutsch | Castillo | Hunt | Corso | Trelle |
arrison | Azevedo | Shen | Anders | Hall | Fredericks | Toueg, Tyler
ha | Davidzon | Chin | Khalighi | Wagner | Mormino
elle | Toueg | Castillo | Channappa | Corso | Hunt |
yakumar | Nadiadwala | Guo | Azevedo | Shin | Trelle, Alexandra
avidson | Deutsch | Hall | Sha | Fredericks | Kerchner
Carr | Chin | Wagner | Mormino
inhas | Yang | Muschelli | Laymon | Zammit | Ellison
ohnson | Mathis | Crainiceanu | Klunk | Handen | Tudorascu, Dana
hristian | Cohen | Tudorascu
udorascu | Comer | Zammit | Laymon | Minhas | Tudorascu, Dana
lison | Zaman | Ances | Johnson | Mathis | Klunk |
hristian | Handen | Hartley | Cohen
scher | Ahnen | Dissertori | Lustermann | Weber | Unschuld, Paul
uck | Kagerer | Gietl | Hock | Unschuld
ianski | Whitwell | Martin | Botha | Schwarz | Duffy |
ark | Spychalla | Senjem | Petersen | Knopman | Jack, Utianski, Rene
| Lowe | Josephs
llemagne | Harada | Doré | Furumoto | Mulligan | Villemagne,
udo | Krishnadas | Huang | Yanai | Rowe | Okamura Victor
okali | Molette | Tsika | Ravache | Rodriguez |
rgens | Melo dos Santos | Sandiego | Russell | Gunn |
armency | Piorkowska | Poli | Kroth | Capotosti | Vokali, Efthymia
iva | Sol | Marek | Stöhr | Lowe | Pfeifer | Kosco-
lbois
ang | Pascoal | Therriault | Benedet | Lussier | Savard Wang, Yi-Ting
Kang | Tissot | Gauthier | Rosa-Neto
ebb | Foster | Horn | Kennedy | Rodrigue Webb, Christina
hitwell | Tosakulwong | Graff-Radford | Weigand | Whitwell, Jennifer
chwarz | Senjem | Ertekin-Taner | Jones | Boeve |
nopman | Jack | Petersen | Lowe | Josephs
iner | Mander | Jagust | Walker Winer, Joseph
olters | Visser | Verfaillie | Coomans | Timmers | Wolters, Emma
uncel | Boellaard | Windhorst | Scheltens | van der Wolters, Emma
ier | Ossenkoppele | van Berckel
olters | Ossenkoppele | Verfaillie | Coomans |
mmers | Visser | Tuncel | Golla | Windhorst |
oellaard | van der Flier | Teunissen | Scheltens | van
erckel
oon | Baker | Korman | Tennant | Harrison | Jagust Yoon, Bora
ammit | Koscik | Laymon | Betthauser | Tudorascu | Zammit, Matt
ohen | Minhas | Johnson | Zaman | Mathis | Klunk |
anden | Christian
ontz | Adams | Baker | Jagust Ziontz, Jacob
hafer | Bilgel | Ziontz | Wong | Resnick Ziontz, Jacob
ukotynski | Gaudet | Kuo | Adamo | Goubran | Scott | Zukotynski,
octi | Borrie | Chertkow | Frayne | Hsiung | Laforce | Katherine
oseworthy | Prato | Sahlas | Smith | Sossi | Thiel |
oucy | Tardif | Black
36
HAI 2020 PROGRAM
Wednesday, Ja
7:30 AM Check-in and Breakfast
8:15 AM Introductions/Welcome Notes
8:30 AM DIDACTIC SESSION A: PET Technical/Meth
8:30 AM Multi-site and longitudinal studies considerations
8:55 AM Centiloids
9:20 AM Computational lead discovery for radioligands
9:45 AM POSTER SESSION 1A and Coffee Break
10:30 AM DIDACTIC SESSION B: Neuropathology
10:30 AM Basic neuropathology of Abeta, tau and a-syn
11:00 AM Technical considerations for IHC, HC, biochemis
11:30 AM Technical considerations for homogenate binding
12:00 PM Maturity states of plaques and tangles
12:30 PM Lunch
1:45 PM SESSION 1: TECHNICAL I
1:45 PM Evaluation of 18F-JNJ-067 as a tau tracer
2:00 PM A direct comparison of tau imaging agents [F-18]
1451 AND [F-18]MK-6240 in human subjects
2:15 PM A multi-center comparison of [18F]flortaucipir,
[18F]RO948 and [18F]MK6240 tau-PET tracers
2:30 PM optimal target ROIs for differential diagnosis
2:45 PM
3:15 PM Capturing extra-cerebral MK-6240 signal with su
3:45 PM projections
4:00 PM
Discussion Session 1
Keynote Lecture
Keynote Discussion
POSTER SESSION 1B and Coffee Break
4:45 PM SESSION 2: TECHNICAL II
4:45 PM Amyloid Load predicts elevated tau deposition in
syndrome
5:00 PM
TauIQ demonstrates increased power for cross-se
5:15 PM and longitudinal analysis of Tau tracers as eviden
[18F]Flortaucipir and [18F]GTP1
5:30 PM
Spatiotemporal imaging phenotypes of tau pathol
5:45 PM Alzheimer’s disease
6:00 PM
6:30 PM Predicting structural, metabolic and pathologic di
progression in autosomal dominant Alzheimer’s d
with machine learning
Correction of partial volume effects for tau PET i
using the kernel method
Discussion Session 2
Welcome Reception
3
anuary 15, 2020
hods Keith Johnson, MD, Massachusetts General Hospital
s CHAIR: Chester Mathis, PhD, University of
Pittsburgh
Robert Koeppe, PhD, University of Michigan
Christopher Rowe, MD, Austin Health
Robert Mach, PhD, University of Pennsylvania
CHAIR: William Klunk, MD, University of
Pittsburgh
Julie Schneider, MD, Rush University
stry Milos Ikonomovic, MD, University of Pittsburgh
g Laetitia Lemoine, PhD, Karolinska Institute
Melissa Murray, PhD, Mayo Clinic
]AV- CHAIRS:
Brad Christian, PhD, University of Wisconsin-
Madison
Ansel Hillmer, PhD, Yale University
Suzanne Baker, PhD, Lawrence Berkeley National
Laboratory
Brian Lopresti, MS, University of Pittsburgh
to detect Rik Ossenkoppele, PhD, VU University Medical
Center
urface Justin Sanchez, BA, Massachusetts General Hospital
Alan Evans, PhD, McGill University
n Down CHAIRS:
Julie Price, PhD, Harvard Medical School
Suzanne Baker, PhD, Lawrence Berkeley National
Laboratory
Matt Zammit, MS, University of Wisconsin
ectional
nced by Roger Gunn, PhD, Invicro
logy in Jacob Vogel, PhD (cand.), McGill University
isease
disease Patrick Luckett, PhD (cand.), KU Leuven/UZ Leuven
imaging Kuang Gong, PhD, MGH/Harvard Medical School
37
Thursday, Jan
7:30 AM Check-in and Breakfast
8:30 AM SESSION 3:
NEUROPATHOLOGY I
Flortaucipir PET often shows uptake greater in re
8:30 AM outside of the medial temporal lobe than in entorh
in low Braak tangle stage participants
8:45 AM Brain volume and [18F]flortaucipir PET analysis
progressive supranuclear palsy clinical variants
Comparison of autoradiographic binding profiles
9:00 AM Flortaucipir, MK-6240 and PI-2620 in human pos
tissue samples across the spectrum of neurodeg. d
9:15 AM Biochemical correlates of tau and amyloid PET im
four autopsy brains
9:30 AM Discussion Session 3
10:00 AM Keynote Lecture
10:30 AM Keynote Discussion
10:45 AM POSTER SESSION 2A and Coffee Break
11:30 AM SESSION 4:
NEUROPATHOLOGY II
11:30 AM Derivation and potential utility of an Abeta-PET b
accumulation index for estimation of brain Abeta
11:45 AM In vitro study of the evidence of tauopathy in PD
a tau PET tracer, [3H]MK-6240, by autoradiograp
12:00 PM In vitro characterization of second-generation tau
in human autopsy brain tissue
12:15 PM Neurofibrillary tangle maturity: a comprehensive
12:30 PM Discussion Session 4
1:00-2:30 Lunch
2:30 PM SESSION 5:
CLINICAL I
2:30 PM History of head injury is associated with greater t
2:45 PM on [18F]Flortaucipir PET in MCI and AD patient
3:00 PM In vivo measurement of widespread synaptic loss
Alzheimer’s disease with SV2A PET
3:15 PM Amyloid PET is more than just positive or negati
3:30 PM amyloid level impacts risk of clinical progression
4:00 PM demented individuals
18F-PI2620 tau-PET in Progressive Supranuclear
multi-center evaluation
Discussion Session 5
POSTER SESSION 2B and Coffee Break
4:45 PM SESSION 6:
CLINICAL II
4:45 PM Tau-PET associations with amyloid positivity and
impairment
5:00 PM Locus coeruleus integrity tracks with initial Alzhe
disease-related pathology and cognitive decline
5:15 PM Area 35 is the earliest subregion in the medial tem
5:30 PM affected by tau pathology
6:00 PM Discussion Session 6
Networking Reception
3
nuary 16, 2020
egions CHAIRS:
hinal cortex Laetitia Lemoine, PhD, Karolinska Institute
Teresa Gomez-Isla, Mass. General Hospital
Val Lowe, MD, Mayo Clinic
s of Jennifer Whitwell, PhD, Mayo Clinic
of Cinthya Aguero, MD, Massachusetts General
stmortem Hospital
diseases
maging in Milos Ikonomovic, MD, University of
Pittsburgh
Julie Schneider, MD, MS, Rush University
CHAIRS:
Melissa Murray, PhD, Mayo Clinic
Julie Schneider, MD, MS, Rush University
based path. Ruben Smith, MD, PhD, Lund University
a load
brains using Zhizhen Zeng, MD, PhD, Merck & Co. Inc.
phy
u pet tracers Mona-Lisa Malarte, PhD (cand.), Karolinska
Institute
e review Christina Moloney, PhD, Mayo Clinic
CHAIRS:
Keith Johnson, MD, Mass. General Hospital
Pedro Rosa-Neto MD, PhD, McGill University
tau deposition Shannon Risacher, PhD, Indiana University
ts School of Medicine
s in early Adam Mecca, MD, PhD, Yale University
ive: Aβ- Christopher Rowe, MD, Austin Health
n in non-
r Palsy: a Matthias Brendel, MD, University Hospital of
Munich
d cognitive CHAIRS:
eimer's William Jagust, MD, U of California, Berkeley
mporal lobe David Wolk, MD, University of Pennsylvania
Susan Landau, PhD, University of California,
Berkeley
Heidi Jacobs, PhD, Massachusetts General
Hospital
David Berron, PhD, Lund University
38
Friday, Jan
7:30 AM Check-in and Continental Breakfast
8:30 AM SESSION 7: TAU I
8:30 AM The implications of different approaches to define
8:45 AM Alzheimer's disease
9:00 AM
9:15 AM Towards a CenTauR cortical mask
Tau Positivity: Comparing Flortaucipir Meta-RO
Maximum of Regional Z-Scores
POSTER SESSION 3A and Coffee Break
10:00 AM SESSION 7: TAU II
10:00 AM Critical threshold of elevated amyloid associated
tau accumulation: a ca-tau-strophe in the making
10:15 AM The Meaning of Tau Positivity with Respect to C
Progression
10:30 AM Longitudinal tau PET changes in cognitively unim
persons with different β-amyloid levels
10:45 AM Defining a tau positive flortaucipir PET signal rel
neuropathology
11:00 AM Discussion Session 7 (TAU I and TAU II)
12:00 PM Keynote Lecture
12:30 PM Keynote Discussion
12:45 PM Lunch
2:00 PM SESSION 8: CLINICAL III
2:00 PM Glucose metabolism reflects local atrophy and tau
at symptomatic stages of Alzheimer's disease
2:15 PM Plasma FLT1 predicts amyloid-β related cognitiv
cognitively normal older adults
2:30 PM
2:45 PM Reducing sample sizes to detect longitudinal amy
3:15 PM accumulation
4:00 PM
Discussion Session 8
POSTER SESSION 3B and Coffee Break
Awards Ceremony
4:15 PM SESSION 9: PLASMA
4:15 PM Plasma P-tau181 as a marker of tau pathology in
disease: relationship to Tau PET, differential diag
4:30 PM neuropathology and longitudinal progression
4:45 PM Plasma levels of an N-terminal tau fragment are h
5:00 PM associated with future cognitive decline and
5:15 PM neurodegeneration in clinically normal elderly: Fi
the Harvard Aging Brain Study
Plasma biomarkers associate with amyloid and ta
binding in cognitively unimpaired older adults wi
history of AD
High-performance plasma phospho-tau181 bioma
Alzheimer’s disease
Discussion Session 9
5:45 PM Closing Notes
3
nuary 17, 2020
e AT(N) in CHAIRS:
Tobey Betthauser, PhD, University of Wisconsin
Sylvia Villeneuve, PhD, McGill University
Antoine Leuzy, PhD, Lund University
OI vs. Vincent Dore, PhD, CSIRO
Christopher Schwarz, MD, Mayo Clinic
with rapid CHAIRS:
Clinical Clifford Jack, MD, Mayo Clinic
Reisa Sperling, MD, Brigham and Women's
Hospital
Victor Villemagne, MD, Austin Health
Keith Johnson, MD, Massachusetts General
Hospital
Michael Devous, PhD, Avid Pharmaceuticals
mpaired David Knopman, MD, Mayo Clinic
lative to AD Michael Pontecorvo, PhD, Avid Pharmaceuticals
Li-Huei Tsai, PhD, MIT
u pathology CHAIRS:
ve decline in Elizabeth Mormino, PhD, Stanford University
yloid Susan Landau, PhD, UC, Berkeley
Amelia Strom, BS, University of California San
Francisco
Hyun-Sik Yang, MD, Brigham and Women's
Hospital
Isadora Lopes Alves, PhD, VUmc
CHAIR:
Gil Rabinovici, MD, UCSF
Alzheimer’s
gnosis, Oskar Hansson, PhD, Lund University
highly
Jasmeer Chhatwal, MD, MGH/Harvard
indings from University
au PET
ith a parental Pierre-Francois Meyer, PhD, McGill University
arker for Tharick Pascoal, PhD, McGill University
Keith Johnson, MD, Massachusetts General
Hospital
39
HAI 2020 ABSTRACTS
Wednesday, January 15, 2020 - 9:45am - 10:30am
P1A: POSTER SESSION
Board Poster Title
#
53 Socioeconomic status mediates racial differences Wisch | H
seen using the A-T(N) Framework Flores | D
01 Label-free x-ray method for estimating brain Badano
amyloid load
Betthaus
02 Examining regional MK-6240 patterns and Convers
associations with amyloid and cognitive decline | Asthana
03 Transcriptomic profiling of brain amyloidosis Bharthur
using peripheral blood-based gene expression
04 A pons cluster detected by a data-driven approach Bischof
may serve as a favorable reference region for 18F- Perrotin
PI-2620 Tau PET analysis
05 Early detection of amyloid load using 18F- Bullich |
Florbetaben PET Sanabria
| Perrotin
Seibyl | B
Age-related neural dedifferentiation of episodic
06 memory networks is related to beta-amyloid and Cassady
tau pathology in normal aging
Tau pathology and synaptic loss are closely Cooman
07 associated in Alzheimer’s disease in vivo: a Ossenko
combined [18F]flortaucipir and [11C]UCB-J PET Schuit | W
study Berckel
Longitudinal dynamic [18F]flortaucipir PET Cooman
08 reveals increased early stage tau pathology in Timmers
Windhor
individuals with subjective cognitive decline
09 Preliminary evaluation of synaptic vesicle protein DiFilipp
SV2A imaging with [11C]UCB-J across the | Engle |
cognitive spectrum
10 Quantifying off-target skull binding in Flores | G
[18F]Flortaucipir PET studies Adedoku
Influence of iron and beta-amyloid deposition on
11 entorhinal cortex and hippocampal subfield Foster | K
volumes in the aging brain
13 Beta-amyloid deposition and its association with Gordon
metabolism Benzing
Amyloid binding is associated with markers of Goubran
14 white matter microstructure in patients with Borrie | C
Laforce
significant white matter disease Scott | S
| Soucy |
Gunter |
15 CSF dynamics explains discrepant PET-CSF AD Kantarci
biomarkers Jones | M
Jack, Jr.
Hippocampal volume mediates the relationship Kim | Ha
20 between amyloidosis and amyloid-sensitive
cognitive composite in preclinical AD
17 [11C]PiB amyloid quantification and choice of Heeman
reference region Lammer
4
N 1A
Authors Presenter Page
Hudson | Coble | Xiong | Babulal | Gordon | Ances, Beau 154
Dincer | Benzinger | Morris | Ances
| Dahal | Ghammraoui Badano, Aldo 43
44
ser | Cody | Koscik | Jonaitis | Erickson | Betthauser, 47
se | Murali | Barnhart | Stone | Mueller | Clark Tobey
a | Christian | Johnson
r Sanjay | Svaldi | Apostolova Bharthur
Sanjay,
Apoorva
| van Eimeren | Koglin | Müller | Bullich | Bischof, 50
| Stephens | Drzezga Gerard
| Roé-Vellvé | Marquié | Villemagne | 57
a | Tartari | Sotolongo | Doré | Koglin | Müller Bullich,
n | De Santi | Tárraga | Stephens | Rowe | Santiago
Boada
y | Adams | Maass | Harrison | Baker | Jagust Cassady, 52
Kaitlin
ns | Verfaillie | Wolters | Tuncel | Golla |
oppele | Scheper | Schober | Sweeney | Ryan | Coomans, 54
Windhorst | Scheltens | Boellaard | van Emma
ns | Visser | Ossenkoppele | Verfaillie | Coomans, 58
s | Wolters | Tuncel | Schmidt | Boellaard | Emma 61
rst | Scheltens | van der Flier | van Berckel 62
po | Murali | McKinney | Davenport | Barnhart DiFilippo,
Betthauser | Johnson | Bendlin | Christian Alexandra
Gordon | Su | Christensen | Dincer | Flores, Shaney
un | Hornbeck | Morris | Benzinger
Kennedy | Rodrigue Foster, Chris 65
| Goyal | Couture | Flores | Morris | Raichle | Gordon, Brian 68
ger | Vlassenko 70
73
n | Ozzoude | Adamo | Zukotynski | Bocti |
Chertkow | Frayne | Gao | Hsiung | Kiss | Goubran,
| Noseworthy | Prato | Ramirez | Sahlas | Maged
Smith | Sossi | Strother | Swartz | Tardif | Thiel
| Black
Senjem | Cogswell | Schwarz | Lowe |
i | Vemuri | Elder | Botha | Graff-Radford | Gunter,
Mielke | Graff-Radford | Knopman | Petersen | Jeffrey
ahn | Kim | Kim | Chin | Seo Hahn, Alice 88
n | Hendriks | van Berckel | Lopes Alves | Heeman, Fiona 80
rtsma | Yaqub
40
Board Poster Title
#
18 Retrospective prediction of amyloid accumulation Hwang |
trajectories in a risk-enriched Alzheimer’s disease Singh
cohort with sequential neural network
19 Data-driven biological pattern scoring of Jones | G
Flortaucipir scans outperforms ROIs Josephs
Knopma
Concordance of visual and quantitative Klein | D
21 assessments of baseline amyloid scans in the Baudler
GRADUATE gantenerumab studies
Regional amyloid burden is associated with higher Kohli | Y
22 quantitative T1 in discrete hippocampal sub- Alexand
regions Bendlin
Genetically informed quantitative Gradient
23 Recalled Echo MRI reveals brain tissue in Kothapa
hippocampal subfields void of neurons in mild Fagan | R
Alzheimer's disease
Validation of highly sensitive and specific Landau |
24 florbetaben positivity thresholds using ADNI Koeppe
participants and young controls
Voxel-wise relationships between white matter Gaubert
12 hyperintensities (WMH) and multimodal Gonneau
neuroimaging biomarkers of Alzheimer’s disease Landeau
Additive contribution of white matter
25 hyperintensity to amyloid and neurodegeneration Lao | Ch
on cognitive decline in a diverse, community- Stern | M
based cohort of older adults
26 White matter hyperintensities are related to tau Lao | La
burden in late-Braak stage regions Luchsing
27 Probability template method for analysis of Down Laymon
Syndrome amyloid PET Tudorasc
28 Visualizing brain astrocytes - characterization of Lemoine
3H-BU99008 in human AD brain tissue
Application of an epidemic spreading model to
29 characterize amyloid beta accumulation in Levitis |
autosomal dominant Alzheimer’s disease mutation
carriers
Phantom-based harmonization of PET image
30 reconstruction parameters between the Siemens Lois | Gr
ECAT HR+ PET and the GE Discovery MI
PET/CT scanners
38 Amyloid PET variability due to variation in MRI Palombi
protocol and anatomical segmentation
39 The impact of automatic Tau PET processing on Palombi
uptake variability and power analysis in AD
31 Age prediction and amyloid deposition in Marterst
SuperAgers Parrish |
PiB tracer delivery decreases overtime in Mayblyu
32 preclinical AD – impact for amyloid pathology Rubinste
Johnson
measurement
34 Sex-specific differences in [18F]AV-1451 off- Minhas |
target retention Aizenste
Polygenic risk for Cerebrospinal Fluid (CSF) Moore |
35 amyloid predicts brain amyloid in clinically Mayeux
normal older adults
36 Association between cerebral amyloid O Dell |
accumulation and synaptic density in Alzheimer’s Banks | K
| Nabulsi
disease: A multitracer PET study Carson |
37 A clinically applicable proxy for gold standard Ottoy | K
quantification of amyloid-beta in Alzheimer’s Hsiao | S
Massarw
disease: Bolus plus constant infusion 18F-AV45
PET
4
Authors Presenter Page
| Koscik | Betthauser | Tao | Kim | Johnson | Hwang, Seong 82
Jae 85
89
Graff-Radford | Botha | Senjem | Wiste | Jones, David 90
| Whitwell | Kantarci | Boeve | Petersen |
an | Lowe | Jack
Delmar | Voyle | Hesterman | Petrulli | Ovens | Klein, Gregory
| Fontoura | Doody | Kerchner
Yang | Vogt | Asthana | Betthauser | Kohli, Akshay
der | Christian | Johnson | Kecskemeti |
alli | Benzinger | Aschenbrenner | Goyal | Kothapalli, 93
Raichle | Morris | Yablonskiy Satya V.V.N.
| Korman | Bullich | De Santi | Stephens | Landau, Susan 94
| Jagust
Lange, 66
| Lange | Garnier-Crussard | Bougacha | Catharina
ud | de Flores | Tomadesso | Mézenge |
u | de La Sayette | Chételat | Wirth
hesebro | Colon | Igwe | Gu | Schupf | Manly | Lao, Patrick 97
Mayeux | Brickman
aing | Igwe | Chesebro | Kreisl | Moreno | Lao, Patrick 98
ger | Brickman 100
102
n | Minhas | James | Christian | Cohen | Klunk | Laymon,
cu | Royse | Zaman | Handen Charles
e | Malarte | Koistinen | Nordberg Lemoine,
Laetitia
Vogel | Kiar | Funck | Iturria-Medina | Evans Levitis, 103
Elizabeth
rogg | El Fakri | Johnson | Price Lois, Cristina 106
it | Manber | Joules | Wolz Manber, 124
Richard 126
108
it | Manber | Joules | Wolz Manber, 109
Richard 115
117
teck | Besson | Sridhar | Makowski-Woidan | Martersteck,
Katsaggelos | Mesulam | Bandt | Rogalski Adam 120
um | Becker | Schultz | Farrell | Jacobs | Mayblyum, 121
ein | Sanchez | Thibault | Sperling | Price | Danielle
| Hanseeuw
| Yu | Laymon | Lopresti | Snitz | Tudorascu | Minhas,
ein | Lopez | Mathis | Klunk | Cohen Davneet
Dumitrescu | Schultz | Raghavan | Johnson | Moore, Annah
| Sperling | Hohman | Mormino
Mecca | Chen | Godek | Harris | Bartlett | O Dell, Ryan
Kominek | Zhao | Naganawa | Toyonaga | Lu
i | Vander Wyk | Varma | Arnsten | Huang |
van Dyck
Kang | Verhaeghe | Stroobants | Bouhachi |
Stevenson | Rahmouni | Chartrand | Ottoy, Julie
weh | Soucy | Gauthier | Rosa-Neto | Staelens
41
Board Poster Title
#
40 MIND MAPS: Assessment of the mitochondrial - Rabiner
endoplasmic reticulum - synaptic axis in Pagano |
neurodegeneration by [18F]BCPP-EF, Middleto
[11C]SA4503 and [11C]UCB-J PET imaging Martarel
Passchie
Rahmou
41 Associations between Neurogranin and imaging Kvartsbe
biomarkers of Alzheimer’s disease Stevenso
Gauthier
42 Linking APOE ε4, blood-brain barrier dysfunction Riphage
and inflammation to Alzheimer’s pathology Verbeek
43 Heterogeneity of tau PET signal in the sub-nuclei Rubinste
of the amygdala Mayblyu
Gomez-I
44 MCI patients demonstrate reliably increasing 18F- Scott | A
AV1451 PET uptake across three exams
45 Development of a qualitative read method for Seibyl | S
characterizing the presence and extent of brain tau Martarel
deposition using [18F]MK-6240 PET imaging
Predicting future amyloid spread with machine Hao | Vo
16 learning using longitudinal [C11]PiB-PET in Christian
preclinical Alzheimer's disease
46 PET imaging of [11C]MPC-6827, a microtoubule- Solingap
based PET tracer in murine models of AD Craft
Quantifying the relationship between the brain
47 distributions of tau and local atrophy to inter- Soucy | M
regional connectivity based on individual human Kang | T
data
Monitoring disease pathophysiology using Stevenso
48 multiparametric PET acquisitions: The McGill Mathota
Tissot | L
TRIAD Cohort Joung | S
Interaction between amyloid and Tissot | K
Chamou
49 neuroinflammation on apathy along the Mathota
Alzheimer’s disease spectrum
Neuropsychiatric symptoms in cognitively Tissot | T
50 impaired individuals are correlated with tau Savard |
Neto | G
deposition
33 MRI and PET data harmonization in a two-site Minhas |
Down syndrome study Ellison |
Handen
51 Association between [18F]NAV4694 PET Wang | P
amyloid-β measures and fluid biomarkers across Savard |
the spectrum of Alzheimer's disease
PET beta-amyloid deposition in healthy older
52 adults is associated with decreased lure Webb | F
discrimination on a spatial mnemonic similarity
task
Tau pathology and relative cerebral blood flow are Wolters
54 independently associated with cognition in Tuncel |
Alzheimer’s disease Flier | O
Amyloid Load trajectories and chronicity reveal Zammit
55 groups of early amyloid accumulators in Down Cohen |
syndrome Handen
Hippocampal-retrosplenial cortex connectivity Ziontz |
56 predicts tau accumulation in cognitively normal
older adults
4
Authors Presenter Page
| Mansur | Venkataraman | Price | Wilson |
| Clarke | Lewis | Matthews | Rowe | Brooks | Rabiner, 127
on | Politis | Rohrer | Comley | Evans | Eugenii
llo | Chen | Schwarz | Schmidt | Tsukada | 131
133
er | Gunn | Consortium 136
uni | Benedet | Nicholas | Tissot | Pascoal | Rahmouni,
erg | Chamoun | Kang | Lussier | Therriault | Nesrine
on | Savard | Mathotaarachchi | Thomas |
r | Zetterberg | Blennow | Rosa-Neto
en | Ramakers | Freeze | Pagen | Hanseeuw | Riphagen,
k | Verhey | Jacobs Joost
ein | Jacobs | Augustinack | Properzi | Becker | Rubinstein,
um | Thibault | Sanchez | Schultz | Hanseeuw | Zoe
Isla | Lois-Gomez | Price | Sperling | Johnson
Adamczuk | Gorman | Runkle | Suhy Scott, David 140
Salinas | Rajagovindan | Hutchison | Beaver | Seibyl, John 141
llo
ogt | Meng | Hwang | Koscik | Betthauser | Singh, Vikas 76
n | Johnson | Bendlin | Singh
Solingapuram 142
puram sai | Macauley | Whitlow | Mintz | Sai, Kiran
Kumar
Mohammadi | Rosa-Neto | Pascoal | Savard | Soucy, Jean- 143
Therriault | Benali Paul
on | Chamoun | A. Pascoal | Benedet | Kang | Stevenson, 144
aarachchi | Therriault | Thomas | Savard | Jenna 145
Lussier | Vinet-Celluci | Rahmouni | Gagné | 147
Sbeiti | Shin | Vitali | Gauthier | Rosa-Neto 111
149
Kang | Benedet | Rahmouni | Pascoal | Tissot, Cécile
un | Therriault | Lussier | Savard |
aarachchi | Thomas | Gauthier | Rosa-Neto
Therriault | Pascoal | Chamoun | Lussier |
Mathotaarachchi | Benedet | Thomas | Rosa- Tissot, Cécile
Gauthier
| Yang | Muschelli | Laymon | Zammit | Tudorascu,
Johnson | Mathis | Crainiceanu | Klunk | Dana
| Christian | Cohen | Tudorascu
Pascoal | Therriault | Benedet | Lussier | Wang, Yi-Ting
Kang | Tissot | Gauthier | Rosa-Neto
Foster | Horn | Kennedy | Rodrigue Webb, 153
Christina
| Visser | Verfaillie | Coomans | Timmers | Wolters, 157
Boellaard | Windhorst | Scheltens | van der Emma 160
Ossenkoppele | van Berckel
Zammit, Matt
| Koscik | Laymon | Betthauser | Tudorascu |
Minhas | Johnson | Zaman | Mathis | Klunk |
| Christian
Adams | Baker | Jagust Ziontz, Jacob 163
42
Badano, Aldo
P1: Label-free x-ray method for estim
Aldo Badano1, Eshan Dahal1, Bahaa Ghammrao
1FDA, Silver Spring, MD, US
We describe a label-free method based on small-angle
amyloid load in vivo in small-animals and humans. Ou
coherently scattered x rays from amyloid plaques in a
x-ray energies above 30 keV. Using a fixed head ex vi
amyloid load in a mouse head with skull without using
energy polychromatic x rays can be efficiently used in
setting to estimate amyloid load. Furthermore, using M
feasibility of using a photon-counting strip detector an
identify amyloid plaques in a human head phantom. P
simulated to assess the method and determine the radi
power. The result shows the potential of the proposed
quantification of amyloid plaques in the human brain
Keywords: SAXS, x rays, amyloid load
4
mating brain amyloid load
oui1
e x-ray scattering (SAXS) for estimating brain
ur method is based on recording and analyzing the
a mouse or human head at angles smaller than 10◦ with
ivo, we demonstrate the feasibility of estimating
g contrast agent. Using our proposed method, high-
n conjunction with a spectral detector in a pre-clinical
Monte Carlo techniques, we have investigated the
nd high-energy x-ray spectra from 30 to 60 keV to
Phantoms with and without amyloid plaques were
iation dose required to obtain acceptable statistical
d method for accurate in-vivo detection and
with acceptable level of radiation dose.
43
Betthauser, Tobey
P2: Examining regional MK-6240 patt
and cognitive decline
Tobey Betthauser1, Karly Cody1, Rebecca Kosc
Converse1, Dhanabalan Murali1, Todd Barnhart
Clark1, Sanjay Asthana1, Bradley Christian1, Ste
1University of Wisconsin-Madison School of Medicine
Objectives: This work investigated MK-6240 timing
(including extra-axial signal impact), in relation to am
unimpaired sample to identify potential composite reg
Methods: Individuals (N=301, 67±8 years, 273 unimp
the Wisconsin Registry for Alzheimer’s Prevention (W
imaging. 70-90 and 90-110 minute SUVR windows w
(n=236 scans). Inter-regional MK-6240 correlations in
with associations with global PIB DVR in a subset wi
positivity thresholds were compared with z-scores det
effects models assessed associations between longitud
duration, and MK-6240 binding in a WRAP subset, co
Results: MK-6240 increased 3-5% in NFT-associated
90 to 90-110 timeframes, respectively. Compared to P
SUVRs, higher inter-cerebral MK-6240 correlations a
ROIs (Fig.1). Three regional groupings were observed
parietal and frontal; visual cortex). MK-6240 positivit
establish z-scores. Regional MK-6240 z-scores indica
early to advanced Braak NFT stages for increasing lev
three-way interactions between age, estimated PIB(+)
for all three MK-6240 composite regions wherein long
associated with faster rates of PACC-3 decline (Fig.3)
Conclusions: These findings suggest that a medial tem
axial spill-in and is associated with early changes in a
4
terns and associations with amyloid
cik1, Erin Jonaitis1, Claire Erickson1, Alexander
t1, Charles Stone1, Kimberly Mueller1, Lindsay
erling Johnson1
e and Public Health, Madison, USA, Madison, WI, US
parameters and inter-regional binding patterns
myloid burden and cognitive decline in a mostly
gions for tau imaging.
paired, 13 MCI, 7 dementia, 8 under evaluation) from
WRAP) and Wisconsin ADRC underwent MK-6240
were compared in a subset covering 70-110 minutes
nside and outside the brain were investigated along
ith PIB imaging (n=286). Regional MK-6240
termined from either PIB(-) or age<64. Linear mixed-
dinal cognitive decline (PACC-3), estimated PIB(+)
ognitively unimpaired at baseline (n=215).
d regions and 10-15% in extra-axial regions from 70-
PIB(-) cases, PIB(+) cases had higher MK-6240
and lower correlations between brain and extra-axial
d for MK-6240 binding (medial temporal; temporal,
ty thresholds were consistent with PIB(-) or age<64 to
ated stepwise increases in regions associated with
vels of PIB (Fig.2). LME models showed significant
) duration at baseline PACC-3 and MK-6240 SUVR
ger PIB(+) duration and higher MK-6240 were
).
mporal composite ROI for MK-6240 minimizes extra-
amyloid and preclinical cognitive decline.
44
4
45
Keywords: tau, preclinical, decline, amyloid, PET
4
46
Bharthur Sanjay, Apoorva
P3: Transcriptomic profiling of brain
based gene expression
Apoorva Bharthur Sanjay1, Diana Svaldi1, Liana
1Indiana University School of Medicine, Indianapolis,
Objective: In an effort towards pre-symptomatic risk
development in AD, we evaluated the efficacy of char
transcriptomic data with respect to brain amyloidosis.
Methods: We identified 356 ADNI participants who
Florbetapir SUVR, neurodegenerative and CSF measu
AD=34) from same visit. Between-group differential e
transcripts (p<0.001). Pairwise Euclidean distance bet
distance matrix followed by K-means clustering to ide
profile (Fig1). We used cluster-level gene enrichment
process associated with each cluster. Using principal c
component as the “eigen-gene”. The eigen-genes were
amyloid SUVR, hippocampus volume, entorhinal thic
genes that beat the eigen-gene association to amyloid
transcripts identified through our analyses were valida
overlapping data types for association to amyloid SUV
Results: We identified five clusters with distinct over
AD pathogenesis. These were mitochondrial function,
phosphorylation and MAPK activation. All five cluste
SUVR and CSF Abeta measures (p<0.05) (Fig 2). The
amyloid SUVR in the ImaGene dataset.
Demographics table
4
amyloidosis using peripheral blood-
a Apostolova1
, IN, US
assessment, precision medicine and biomarker
racterizing and clustering peripheral blood
.
had corresponding blood gene expression,
ures (Table 1) (CN=120, EMCI=130, LMCI=72 and
expression analyses yielded 864 genes from ~50,000
tween genes was used to construct a gene-gene
entify clusters of genes with similar transcriptomic
t analysis to identify the most relevant biological
component analysis, we assigned the first principal
e used to assess the association of the clusters to
ckness, CSF Abeta and p-tau measures. The top driver
SUVR were identified from each cluster. The
ated in an external dataset (ImaGene) with
VR.
rrepresented biological processes highly relevant in
, protein oligomerization, TGF beta signaling, protein
ers were significantly associated with Florbetapir
e top driver genes showed similar correlation to
47
4
48
Conclusions: Using a data driven approach we found
transcripts which were significantly correlated to amy
blood show promise as non-invasive markers for AD
genes and their metabolic pathways are warranted.
Keywords: blood biomarkers, amyloid burden, genetic
4
d five AD-relevant clusters of peripheral blood RNA
yloid burden. Systems level genetic signatures from
pathology. Further investigations into the driver
c profiling, CSF measures
49
Bischof, Gerard
P4: A pons cluster detected by a data-
favorable reference region for 18F-PI-
Gerard Bischof1, Thilo van Eimeren1,3,4, Norma
Audrey Perrotin5, Andrew Stephens5, Alexande
1Multimodal Neuroimaging Group, Department of Nu
Cologne, Germany
2Department of Neurology, University Hospital Colog
3Department of Neurology, University Hospital Colog
4German Center for Dementia Research (DZNE), Bon
5Life Molecular Imaging GmbH, Berlin, Germany
6Molecular Organization of the Brain, Institute for Ne
Cologne, Germany
One of the current challenges in static tau PET imagin
for count normalization and definition of thresholds fo
disease-related tau pathology. For the available tau-se
cerebellum (e.g., superior cerebellar peduncles, dentat
been reported, rendering the cerebellum as a suboptim
approach may allow to identify regions with negligibl
suitable reference region. Using proportional scaling f
any specific tracer retention can be expected to exhibi
compared to controls. Here, we tested this approach in
negative controls (N=10) who underwent 18F-PI-2620
45-75 minutes p.i., were summed and normalized to th
statistical non-parametric mapping algorithm. A two-s
which regions of the brain elicited relatively lower sig
cluster threshold. The identified clusters were located
stem. These regions were then tested as reference regi
healthy controls and AD patients. The whole mask, pr
followed by the pons cluster (d= 2.5) compared to a ce
underscores the utility of a data-driven approach for id
suggest that a specific pons cluster may show favorab
2620 PET imaging data. Further cross-validation in cl
Keywords: Tau PET, Reference Region, 18F-PI2620,
5
-driven approach may serve as a
-2620 Tau PET analysis
an Koglin5, Andre Müller5, Santiago Bullich5,
er Drzezga1,4
uclear Medicine, University Hospital Cologne,
gne, Cologne, Germany
gne, Cologne, Germany
nn, Germany
euroscience and Medicine (INM-2), Jülich, Germany,
ng is the establishment of a suitable reference region
or consistent identification of individuals with
elective tracers, retention in certain sub-regions of
te nuclei) in both healthy and disease populations has
mal reference region. A hypothesis-free data-driven
le levels of target expression which may serve as a
for group comparison, regions consistently void of
it relatively lower signal in target-positive patients as
n a cohort of AD patients (N=12) and amyloid-
0 imaging and MRI scanning. Dynamic frames from
he individual MRI, skull-stripped and submitted to a
sample t-test using proportional scaling examined
gnal in AD compared to controls with a FWE p<.05
in thalamus, pons, cerebral white matter and brain
ions to examine differences in cortical uptake between
roduced the highest effect size (d= 2.6), closely
erebellar crus region (d= 1.0).Together, this data
dentification of a suitable reference region and
ble properties as a reference region for static 18F-PI-
linically diverse samples may be justified.
static imaging
50
Bullich, Santiago
P5: Early detection of amyloid load us
Santiago Bullich1,2, Núria Roé-Vellvé1,2, Marta
Sanabria3,4,5, Juan Pablo Tartari3,5, Oscar Sotolo
Andre Müller1,2, Audrey Perrotin1,2, Susan De S
Stephens1,2, Christopher C. Rowe6, John P. Seib
1Life Molecular Imaging GmbH, Berlin, Germany
2On behalf of the AMYPAD Consortium, Brussels, Bel
3Fundació ACE Institut Català de Neurociències Apli
Universitat Internacional de Catalunya, Barcelona, S
4Centro de Investigación Biomédica en Red Enfermed
Salud Carlos III, Madrid, Spain
5On behalf of the FACEHBI study group, Barcelona, S
6Departments of Medicine and Molecular Imaging, U
Australia
7Life Molecular Imaging Inc, Boston, MA, US
8Invicro, New Haven, CT, US
Introduction: Pathology-proven 18F-Florbetaben (FB
to discriminate between Alzheimer’s disease patients
(SUVR=1.48 (Sabri et al. 2015)). However, observati
trials focus on the early stages of Aβ deposition. A low
previously developed SUVR cutoffs. The objective of
abnormality cutoff to detect early Aβ deposition and t
Aβ.
Methods: SUVR cutoff was derived from a sample of
2 standard deviation above the mean SUVR. Subseque
studies: (1) Individuals with subjective cognitive decli
(FACEHBI) study) (n=166; 64.9±7.2 y (Rodríguez-G
(MCI) subjects (n=45, 72.69 ± 6.54 y) (Ong et al. 201
using MRI-based regions of interest (reference region
using the standard centiloid (CL) analysis (reference r
Results: Mean SUVRs derived from YHC was 1.16±0
1.02±0.4 (SUVRcutoff=1.09, CLcutoff=12) (CL). Three r
negative subjects (SUVR<1.25), early Aβ accumulatio
deposition (SUVR>1.48). In the test datasets, only sub
0.94±1.6 %/year (MCI)) or “established Aβ pathology
accumulated amyloid in a statistically significant man
Conclusions: An SUVR range from 1.25 to 1.48 is op
subjects that are likely accumulating Aβ.
Keywords: florbetaben, amyloid, SUVR, cutoff
5
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