Microbioz India, September 2022 Lab Edition

Product Showcase

The SITESEEKER® platform is based on NEW Compact
Chilling/Heating Dry Bath for
PhoreMost’s core proprietary ‘Protein Interference’ Robotic Systems

(PROTEINi®) technology. PhoreMost probes the Story source/Credit: Torrey Pines Scientific Inc

entire proteome in a live cell environment for novel

druggable targets linked to any chosen disease, using

the vast 3-D shape diversity of natural protein

fragment (sub-domain) libraries.

SITESEEKER®systematically unmasks new and

unanticipated druggable sites across the entire

human proteome, directly linking them to useful

therapeutic functions.

Dr Neil Torbett, CEO of PhoreMost, said: “This

collaboration with Roche is testament to the power

and versatility of SITESEEKER, and further

validates the potential and broad applications of the

platform. We are delighted that Roche has chosen

to work with us to enhance its drug discovery

pipeline using PROTEINi and SITESEEKER to

identify novel targets and unlock the power of

protein structure prediction for next generation

drug design.”

About PhoreMost Ltd Torrey Pines Scientific announces its

PhoreMost has developed a next-generation EchoTherm™ RIC40 Peltier-driven,

phenotypic screening platform called compact Chilling/Heating Dry Baths with

SITESEEKER® that can discern the best new temperatures settable from 0.0ºC to

targets for future therapy and crucially, how to drug 100.0ºC., designed for use with Robotic

them, which has the potential to significantly Systems and controlled via the RS232 I/O

increase the diversity and affordability of novel port on each RIC40 unit.

therapeutics for cancer and other unmet diseases. The RIC40 measures 4.9” (125 mm) long by
3.3” (82 mm) wide by 3.9” (99 mm) tall
Based on the Company's core proprietary 'Protein without a sample block. Offered as
accessories are mounting brackets for Tecan decks
Interference' technology, and the broad variety of precision-made aluminum
sample blocks.
SITESEEKER® systematically unmasks cryptic The RIC40 can be set to 0.1ºC and is stable to +/-
0.2ºC. Temperature accuracy to +/- 0.2ºC. Each
druggable sites across the entire human genome and unit comes complete with chiller/heater module,
universal power supply, AC line cord for the
directly links them to useful therapeutic functions in country of use, RS232 interconnect cable and
instructions including the Serial Command Set.
a live-cell context. Using this platform, PhoreMost All units are UL, CSA, and CE compliant.

is building a pipeline of novel drug discovery

programmes aimed at addressing a range of unmet

diseases.

Microbioz India, September 2022 | 51

Product Showcase

Queensgate, a brand of The stage incorporates capacitive positioning
Prior Scientific, introduces sensors to provide nanometer displacement
a new high-load Piezo measurement and precision closed-loop
wafer Z stage feedback. Flexure guidance offers friction-free,
reliable motion to more than 120 µm in closed-
Story source/Credit: Prior Scientific Instruments loop mode and achieves fast response and settle
Ltd. times with Queensgate’s digital closed-loop
controllers.
Queensgate’s wafer Z stage is a new “We are pleased to introduce WP-Z-120A Wafer
addition to its product line, achieving fast Scanner to the market. We wanted to design a
response and settle times using wafer scanner that can carry a high
Queensgate’s leading digital closed-loop load but achieves market-leading fast response
controllers and settle times,”said Alison Raby, Business
Development Manager for Queensgate, “The
Queensgate, a brand of Prior Scientific, has Wafer Scanner was designed with OEM
announced the launch of the WP-Z-120A customers in mind and can be adapted to new
Wafer Stage. Millisecond response times custom versions easily.”
and high bandwidth make the WP-Z-120A wafer WP-Z-120A Wafer Stage can be customized for
positioning system ideal for applications where different environments and specifications. It is
high throughput is essential. The Wafer Stage can vacuum (HV) compatible and ideal for a chamber
be used in wafer inspection with an optical in an electron microscope. Ultra-high vacuum
microscope such as the Prior Scientific (UHV) and UHV-RAD radiation-hard versions
OpenStand microscope or an OEM version using are also available. A higher load custom version
various optical or other inspection techniques. can be used for up to 14 kg loads and a tip-tilt
The stage is designed to hold 300 mm (12") version for platform leveling and scanning is
wafers and delivers an exceptional performance available. An extended range of 160 μm and a
with a load capacity of up to 8 kg, suitable for smaller size for 200 mm wafers are possible upon
even very heavy wafer chucks. request.

About Queensgate

Queensgate, a brand of Prior Scientific, has over
40 years of experience providing custom and
OEM nanopositioning solutions where precision,
accuracy, and dynamic performance are required.
Queensgate offers market-leading performance
due to enhanced control technology. Many of
Queensgate’s products are used in demanding
environments such as ultra-high vacuum, high
throughput manufacturing, and space equipment.
Over half of the world’s hard disks are tested
using Queensgate’s ultra-precision stages.
Queensgate is based in Cambridge in the UK with
manufacturing facilities in Paignton UK and
regional operations in the US, Germany, China
and Japan.

Microbioz India, September 2022 | 52

Product Showcase ValitaCell technologies are patented in key
international markets and the company has been
ValitaCell Joins honored with several awards, including the Irish
Beckman Coulter Life Pharmaceutical Awards’ Pharma Start-up of the
Sciences Year in 2017 and InterTrade Ireland’s Seedcorn
awards. It also was recognized as one of the most
Story source/Credit: Beckman Coulter Life successful Irish companies in Horizon 2020.
Sciences “Throughout our trusted partnership with
ValitaCell, we have long admired their innovative
Beckman Coulter Life Sciences, a global leader in offerings and industry expertise,” said Jason
laboratory automation and innovation, announces Lanie, Vice President and General Manager of the
it has acquired ValitaCell Ltd. (“ValitaCell”), a Biotechnology Business Unit at Beckman Coulter
biotechnology company that creates pioneering Life Sciences. “Their leading portfolio of
analytical products and technologies for the products, including ValitaTiter, Quantum, CellAi,
biopharmaceutical industry. and ChemStress Clone Robustness complement
Beckman Coulter Life Sciences’ existing and
Headquartered in Dublin, Ireland, future product portfolio, and are designed with
ValitaCell creates analytical technologies the same goal of providing faster cellular analysis
and products for the biopharmaceutical while decreasing the risk of errors. We are excited
industry with the goal of reducing new to welcome their team and look forward to
therapeutics' cost and time to market. Compared growing the Ireland Innovation and
to other industry IgG quantification assays, the Development Centers for Biologics to help meet
ValitaTiter product outperforms in terms of evolving customer needs.”
speed and ease of use, and offers numerous ValitaCell locations in Dublin and Galway,
advantages over other long and tedious Ireland will remain operational and are
techniques, like ELISA and HPLC. anticipated to grow in response to business needs.
“ValitaCell has a proven record for delivering
innovative products and we are excited to build About Beckman Coulter Life Sciences
upon our successful partnership with Beckman
Coulter Life Sciences,” said Dr. Jerry Clifford, Life sciences. Research. Precision manufacturing.
Co-Founder and CEO of ValitaCell. “We never
take for granted what our advancements can do If your life’s calling is in any of these or related
for patients while also reducing manual workflow
burdens on laboratory staff. Together with fields, you need to know Beckman Coulter Life
Beckman Coulter Life Sciences, we will advance
our shared ambition to accelerate and enable the Sciences. Our mission is to empower those
sustainable manufacture of innovative biological
medicines to bring them to market faster.” seeking answers to life’s important scientific and

healthcare questions. Since 1935, the Beckman

name has been synonymous with technologies

that simplify and automate complex biomedical

testing. Decades later, our global organization

also came to embody the scientific legacy of the

Coulter name. Today, Beckman Coulter Life

Sciences is a trusted, worldwide resource for tools

to help optimize research and manufacturing

efficiency. Centrifuges. Particle

counters/analyzers. Automated liquid handlers.

Flow cytometers. Genomic reagents. All these

products—and many more—continue to make a

difference in people’s lives by improving the

productivity of dedicated scientists, quality

control experts and others.

Microbioz India, September 2022 | 53

Product Showcase

Wherever people need answers, from Waters Collaborates with Leading
prestigious universities and major Researchers and Industry
pharmaceutical companies, to small Partners to Advance the Science
biotech startups, food/beverage and of Alternative Proteins
electronics manufacturing facilities,
you can find Beckman Coulter Life Story source/Credit: Waters Corporation
Sciences.

About ValitaCell Researchers will use Waters’ ACQUITY Premier
UltraPerformance Liquid Chromatography
ValitaCell’s mission is to accelerate the pace and
reduce the cost of manufacturing innovative (UPLC™)-driven workflow to simplify analyses
medicines. We are focused on enabling our and become a standard measure of amino acid
biopharmaceutical customers to bring medicines
to the patients that need them most, in the compositions in alternative proteins
shortest length of time. The majority of drugs that
advance to clinical trial fail before they make it to Waters Corporation announced it is
the market. This failure increases costs and delays providing both technology and
life-saving treatments for patients. Our team is expertise to help advance plant-based
focused on creating analytical technologies that protein science in collaboration with researchers
empower scientists with rich cell data and insights of the Plant Protein Innovation Center (PPIC) at the
earlier in the drug discovery and development University of Minnesota.
process. We are committed to advancing human
healthcare worldwide.

Microbioz India, September 2022 | 54

Product Showcase While humans produce 11 of these amino acids,
the remaining nine amino acids are essential for
Waters scientists will work with PPIC researchers human health and are derived only from plant or
to develop a workflow for measuring the amino animal sources.
acid content of plant-based proteins using Amino acid analysis provides a basic measure of
a Waters ACQUITY™ Premier UPLC System. the functional and nutritional value of both
Waters is the first analytical instrument company animal and plant-based proteins slated for
to become a member of the PPIC, an industry- consumer food products. Any research into
leading interdisciplinary research center dedicated plant-based proteins requires a way to measure
to studying plant and alternative proteins. their amino acid content, for which liquid
chromatography is particularly well-suited.
According to a July 2022 report by Boston About Waters Corporation
Consulting Group, animal agriculture is the Waters Corporation (NYSE:WAT), a global
largest global greenhouse gas emitter within the leader in analytical instruments and software, has
food system and accounts for 15% of global pioneered chromatography, mass spectrometry,
emissions. If alternative proteins stay on track to and thermal analysis innovations serving the life,
match the taste, texture and price of conventional materials, and food sciences for more than 60
animal proteins, researchers estimate they will years. With more than 7,800 employees
account for an 11% share of the food market by worldwide, Waters operates directly in more than
2035 and account for a reduction in CO2 35 countries, including 14 manufacturing
emissions equal to 95% of today’s aviation facilities, and with products available in more than
industry emissions. i 100 countries.
“Just as climate change and population growth are Waters, ACQUITY, and UPLC are trademarks of
driving demand for alternatives to animal protein, Waters Corporation.
changing consumer tastes are also creating a
preference for healthy and more sustainable Cryogenic Homogenization
dietary options to meet their future needs and of Food Samples
wants,” said Warren Potts, Senior Director,
Global Food and Environmental Business, Story source/Credit: Retsch GmbH
Waters Corporation. “Waters is proud to be the
first analytical instrument company to join PPIC Tough? Fatty? Fibrous? No problem for
in its pursuit of alternative sources of proteins Retsch’s GRINDOMIX GM 200 knife mill
while addressing the issues of climate change and which is perfectly suited to homogenize
food security.” dry, oily, fatty, soft and tough sample
“As we translate research to reality through materials - for analysis results with
developing and introducing novel and sustainable minimum standard deviation.
plant protein ingredients and products with
acceptable functionality and nutrition, we rely A range of new accessories makes the GM
heavily on robust and accurate analytical tools,” 200 suitable for cryogenic grinding of very
said Dr. B. Pam Ismail, Founder and Director of sticky or moist samples by using dry ice.
the PPIC. “PPIC and its member organizations
are, therefore, thrilled to partner with Waters to
advance our analytical capabilities for the
alternative protein market.”

Liquid Chromatography is Essential for
Amino Acid Analysis

Proteins are made up of 20 chemicals ‘building
blocks’ called amino acids. The amino acids we
make ourselves or that we take in with food, link
together in different combinations to make new
proteins that help build and repair muscles,
tendons, and organs.

Microbioz India, September 2022 | 55

Product Showcase

The so-called cryo kit offered by Retsch for this Enabling Improved Multiplexed
purpose consists of a full-metal knife and a special Proteomics and Native Protein
stainless-steel grinding container with lid. Characterization
To prevent overpressure inside the closed jar caused
by the frozen CO2, which is warmed during the Thermo Fisher announces the new Thermo
grinding process with dry ice and evaporates, the Scientific Orbitrap Ascend Tribrid mass
special lid features a small opening to let carbon spectrometer, offering new capabilities for
dioxide escape. multiplexed proteomics and native protein
characterization. The mass spectrometer enables
The GRINDOMIX GM 200 knife mill covers a improved sample throughput, versatility, and
wide application range, from granular products like ease-of-use—producing high quality data with
rape seed, rice, soybeans to fibrous or tough simplicity. More samples can be analyzed at lower
samples like meat, fish, candy, cheese or plants. It concentrations, enabling faster, more sensitive
processes sample volumes up to 700 ml quickly and analysis, and macromolecule experiments, that
effectively. Parameters and programs are set via the were not possible before, can now be achieved.
convenient touch display, ensuring reproducible The new Auto-Ready ion source for calibration
homogenization. maximizes convenience, allowing the user to
spend more time on the results, and less time on
Thermo Fisher Scientific Showcases instrument set-up.
Latest Innovations to Improve "Building upon the proven Tribrid architecture,
Biopharmaceutical and Proteomics our new mass spectrometer was designed for
Workflows customers to address the most difficult analytical
challenges," said Rosy Lee, vice president and
Story source/Credit: Thermo Fisher Scientific general manager, life sciences mass spectrometry,
Thermo Fisher Scientific. "The instrument
New mass spectrometry instrument provides a single, versatile platform with single-
and consumables launch during cell sensitivity for proteomics and metabolomics,
IMSC 2022 producing high-quality data with ease. This
enables customers to tackle challenging analytes
Thermo Fisher Scientific Inc., the world required to scale up their science."
leader in serving science, launches a new Joshua Coon, PhD Principal Investigator, Coon
mass spectrometry instrument and Laboratories, University of Wisconsin-Madison,
consumables that enable biopharmaceutical and said, "One feature on the Orbitrap Ascend
proteomics customers to drive scientific Tribrid MS that is very exciting is its ability to
breakthroughs and solve analytical challenges. route multiple ions. By moving the collision cell
The company is showcasing these innovations forward, the speed of the system is increased,
during the International Mass Spectrometry allowing us to dig deeper into a sample and detect
Conference (IMSC), August 27-September 2, more, quicker."
2022, Booth 6, in the Maastricht Exhibition &
Congress Centre (MECC), Maastricht, Single Vendor Solution with Unique Low-
Netherlands. Flow HPLC Columns

Thermo Fisher Scientific now offers proteomics
and biopharmaceutical researchers a solution for
extra-high-resolution LC-MS proteomics with the
extension of their μPAC HPLC columns range.
Following the launch of the 50 cm μPAC Neo
HPLC Column earlier this year, the company now
offers the following columns in the range:

Microbioz India, September 2022 | 56

Product Showcase Bio-Rad Introduces Anti-
Evolocumab Antibodies for Use
50 cm μPAC Neo HPLC column for high- in Preclinical and Clinical Drug
throughput proteomics analysis Development
New 50 cm Low-Load μPAC Neo HPLC column
for single cell and multiplexed sample analysis Story source/Credit: Bio-Rad Laboratories, Inc.
New 110 cm μPAC Neo HPLC column for deep
dive proteomics analysis Bio-Rad Laboratories, Inc., a global leader in life
The columns provide ultra-high resolution to science research and clinical diagnostic products,
extract the maximum amount of information has introduced a range of type 1 antibodies that
from highly complex samples with low-flow inhibit the binding of evolocumab (Repatha®) to its
chromatography. The increased separation target, human proprotein convertase
performance enables improved protein subtilisin/kexin type 9 (PCSK9), a protein that has
identifications, and more reliable data been shown to play a key role in the regulation of
interpretation. Each of the μPAC Neo HPLC cholesterol levels. These sequence-defined,
columns are manufactured using the same recombinant antibodies are suitable for developing
lithographic mask, producing columns that are highly selective and sensitive pharmacokinetic
highly reproducible, delivering better column-to- (PK) and anti-drug antibody (ADA) assays for
column consistency and column lifetime evolocumab and its biosimilars.
compared to packed bed columns. This makes
method development, method validation, and Evolocumab is a monoclonal antibody
large sample batch studies simpler. The easy-to- used for the treatment of hyperlipidemia,
use Thermo Scientific nanoViper Fingertight or elevated levels of cholesterol and other
Fitting connections offer column connection lipoproteins. It binds to PCSK9, preventing its
reliability and ensure optimal separation interaction with low-density lipoprotein (LDL)
efficiencies. receptors to reduce circulating cholesterol and
other lipoproteins. The new range of five anti-
About Thermo Fisher Scientific evolocumab antibodies includes fully human
IgG1 clones and TrailBlazer Antibodies with a
Thermo Fisher Scientific Inc. is the world leader SpyTag incorporated into their heavy chain,
in serving science, with annual revenue of enabling site-directed conjugation or fast-
approximately $40 billion. Our Mission is to switching to a bivalent Fab or a full-length Ig-like
enable our customers to make the world healthier, format within an hour.
cleaner and safer. Whether our customers are
accelerating life sciences research, solving
complex analytical challenges, increasing
productivity in their laboratories, improving
patient health through diagnostics or the
development and manufacture of life-changing
therapies, we are here to support them. Our
global team delivers an unrivaled combination of
innovative technologies, purchasing convenience
and pharmaceutical services through our
industry-leading brands, including Thermo
Scientific, Applied Biosystems, Invitrogen, Fisher
Scientific, Unity Lab Services, Patheon and PPD.

Microbioz India, September 2022 | 57

Product Showcase

The antibodies can be used to develop PK New ibidi Silver Line Stage Top
bridging ELISAs to measure free drug or as a Incubators
surrogate positive control or reference standard
in an ADA assay. Story source/Credit: Thistle Scientific
“Bio-Rad’s range of ready-made and well-
characterized anti-idiotypic antibodies keeps Are you planning a live cell imaging experiment?
growing, offering researchers enhanced flexibility Do you want to get stunning time-lapse images
for the development of custom bioanalytical drug with maximal quality? Then the new ibidi 'Silver
assays against a wide range of marketed biologic Line' Stage Top Incubators are the ideal solution
drugs,” said Hilary Latham, Bio-Rad Marketing for you.
Director, Life Science Group. “Generated under
stringent quality control for batch-to-batch Thistle Scientific proudly introduce the new
consistency, these antibodies can produce ibidi Silver Line stage top incubators.
translatable and reproducible results, ensuring Building on the success of ibidi's current
assay reliability.” range of stage top incubators, the Silver Line
The recombinant antibodies are generated using range provides an optimal environment for cell
the Human Combinatorial Antibody Library growth during live cell imaging
(HuCAL®) and CysDisplay®, a proprietary
method of phage display, along with guided
selection methods to obtain highly targeted
reagents. The recombinant production method
also ensures a consistent and secure supply
throughout the assay lifecycle.
The anti-evolocumab antibodies are approved for
in vitro research purposes and for commercial in
vitro testing services to support preclinical and
clinical drug development.

BIO-RAD is a trademark of Bio-Rad
Laboratories, Inc. in certain jurisdictions.
HUCAL and CYSDISPLAY are trademarks of
MorphoSys AG.

Microbioz India, September 2022 | 58

Product Showcase New MALDI-8030 Dual-
Polarity Benchtop Linear
Cells react sensitively to changes in their MALDI-TOF Mass
environment. Factors such as temperature, Spectrometer from Shimadzu
humidity/evaporation, and CO2/O2 levels
significantly influence the outcome of cell culture Story source/Credit: Shimadzu
assays. Therefore, it is crucial to maintain optimal
conditions on the microscope stage during live High-performance range of MALDI-
cell imaging experiments to achieve biologically TOF Mass Spectrometers offers new
relevant and reproducible results. compact alternative
The ibidi Stage Top Incubators – Silver Line
combine the ibidi Heating System – Silver Line Shimadzu, a global leader in analytical
and the ibidi Gas Incubation System – Silver Line. instrumentation, has announced the release
The ibidi Heating System creates stable and of the MALDI-8030. The new instrument
homogenous temperatures for high-resolution offers a versatile, space-saving, easy-to-use, high-
live cell microscopy. It fits into inverted performance alternative, and expands the range
microscope stages with a universal mounting of solutions offered by Shimadzu's industry-
frame for multiwell plates. When placed in the standard family of benchtop matrix-assisted laser-
ibidi Heated Chamber, the cell culture vessels are desorption/ionization time-of-flight (MALDI-
kept at a stable, defined temperature during the TOF) mass spectrometers.
live cell imaging experiment on the microscope.
The ibidi Gas Incubation System provides humid VERSATILITY
and CO2-rich air for stage top incubators like the Similar to the top-of-class MALDI-8020, the new
ibidi Heating System. The gas mixture is MALDI-8030 uses the same innovative and
continuously flushed through the stage top award-winning sleek instrument design to
incubator, ensuring maximum humidity and an produce a compact footprint, while still achieving
optimal pH for bicarbonate-buffered liquids. performance specifications similar to larger, more
For hypoxia assays, the ibidi Stage Top expensive MALDI-TOF models.
Incubators, CO2/O2 – Silver Line allow for the
precise control of the oxygen levels in your cell
culture vessel. The ambient O2 level can be
controlled within a range of 1%–21%, and easily
adapted to the experimental requirements.
Improvements to evaporation control,
condensation and xyz-stability are included. The
Silver Line incubators include a universal fit
system, for easy installation on most inverted
microscopes. These systems are capable of
controlling humidity, CO2, O2, temperature and
now have an optional objective heater to prevent
the sample cooling, thus maintaining a defined
and stable sample temperature during high-
resolution live cell imaging.
Ibidi Silver Line systems are available in the UK
exclusively from Thistle Scientific.

Microbioz India, September 2022 | 59

Product Showcase

The added feature of a dual-polarity ion source The absence of desiccant and use of an oil-free
provides further versatility to users who wish to diaphragm pump reduce maintenance costs. In
analyze molecules in both positive and negative addition, the MALDI laser has an impressively
ion mode. class-leading lifetime of 2 billion shots.
With its outstanding functionality, routine
USER-CENTRIC DESIGN workflows for academic, QC and regulatory
laboratories are all executed smoothly on the new
Based on a user-centric concept, the MALDI- MALDI-8030. The integrated barcode scanner
8030 is remarkably easy to use. Intuitive, built-in enables a seamless tracking process from loading
MALDI Solutions software caters to both samples to obtaining results. Additionally, the
advanced and novice users alike. The multi-LED popular MALDI Solutions software offers high-
front panel keeps users accurately informed of level data security to help meet 21 CFR Part 11
instrument status, and the instrument operates at compliance, including password-controlled user
a comfortably quiet level of sound (< 55 dB). access.
Commenting on the release of the new MALDI-
SPEED 8030, Mr. Kozo Shimazu, Managing Director of
Kratos Analytical (a wholly owned subsidiary of
The Fast-MS design combines a lively solid-state Shimadzu Corporation), said, “I am very proud to
laser (200 Hz) with quick sample stage announce the launch of the MALDI-8030. Kratos
movement, a high-speed transient recorder for Analytical has a long history of ‘firsts’ with
rapid data transfer, and a load-lock system for MALDI-TOF technology, going back 30 years to
swift sample target introduction. This impressive when we released the world’s first benchtop with
array of attributes accelerates time-to-results the ‘KOMPACT MALDI’ benchtop instruments.
turnover and improves laboratory productivity. The MALDI-8020 is a best-in-class positive ion
mode linear MALDI-TOF benchtop, and we
SENSITIVITY have listened to our customers’ needs and are
now providing negative ion mode analysis in the
The dual-polarity ion source and the patented same small form format. Both the MALDI-8020
WideBoreTM ion optics provide top-level and the new MALDI-8030 offer excellent
sensitivity and mass resolution, enabling low-level performance, so our customers will continue to
detection of proteins, peptides and polymers, have speed with accuracy, and can now also have
among other analytes, in either positive or that in a compact and economic package.”
negative ion mode. The MALDI-8030 was first previewed in
November 2021 at the Japan Analytical &
PERFORMANCE Scientific Instruments Show (JASIS) in Tokyo,
Japan. Its release further consolidates Shimadzu’s
Designed as a true laboratory workhorse, the status as a thought leader in this market segment.
MALDI-8030 also facilitates routine maintenance
and maximizes instrument up-time with the use
of the patented TrueCleanTM function, which
performs automated UV laser self-cleaning of the
ion optics.

Microbioz India, September 2022 | 60

Product Showcase

A Laboratory’s They can be considered a bespoke design, albeit
Sterile Waste
Exit Path one that is created by adding a second door to a

Story source/Credit: Priorclave Ltd standard model. This is where the UK autoclave

150L - 700L Double-Door Autoclaves / design and manufacturing centre of Priorclave is
Pass-Through Autoclaves
essential. With total control over autoclave build,
The set-up of many critical research and
development laboratories may require a the company often adapts a standard steam
sterile path in an out of the working area.
There may be air locks for staff to pass through, steriliser or develops a unique autoclave to meet
extracting, cleanings and renewing the air, a
system in operation where high-risk conditions customer requirements
are the norm, such as a containment suite. In a
All sterilising processes are controlled through
similar manner, some laboratories need to have a
secure, clean exit path for its waste so that it can the very latest Tactrol®3 controller. Depending
be safely discarded. As a dedicated autoclave
design and manufacturing company Priorclave on the application Priorclave will configure layout
can build pass through (also known as double-
door) research grade laboratory autoclaves to of the Tactrol® controller to suit lab
meet specific requirements.
By installing a Priorclave pass-through (double-door) requirements. A typical set-up could be that only
research grade laboratory a sterile path in and out of
the laboratory can be easily maintained. This one side of the double door steriliser has access
British autoclave manufacturer can supply pass
through autoclave with sterilising chamber to the full control system, the other side of the
capacities up to 700 litres.
autoclave equipped with just a screen to show

process status so that staff are aware when a job

is complete, and it is safe to remove the media or

waste.

These robust designs have an uncompromising

level of safety that include advanced interlock

setting preventing the simultaneous opening of

doors at either end of the

chamber.

The overall design and

build of each double-door

autoclave takes place

at Priorclave’s UK

manufacturing centre where

the company introduces a

robust bulkhead mount to

facilitate a strong

structural fix into a

dividing wall between the

sterile lab and non-sterile

areas. Once installed the

double-door Pass-

Through research

autoclave is the perfect

partner working as an

interface between sterile and non-sterile areas.

Since each installation site is different, it may

require doors to be hinged on the left or right as

well as consideration given to location of

electrical, water and drain services. This is where

the in-depth knowledge of the Priorclave sales

and service team is a value asset, they are always

on hand to advise on critical installation issues,

ensuring the autoclave build program

accommodates local site requirements for a

smooth path from delivery to installation and

operation.

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PUBLISHED ON: 25th September 2022 RNI NUMBER: UPENG/2017/73675
2022

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