Microbioz India, February 2023 Health Edition

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Microbioz India, February 2023 | 6 32 34 10 22 29 10 18 Cover Story 5 Things to Consider Before Buying Ultrasound Featured Article Ultra-High Frequency digital mobile X-Ray solution Business News Wearable ultrasound tech coming soon with accurate real-time heart scans Product Launches QIAGEN Launches Automated Sample Processing Platform for Diagnostic Labs 10 14 20 42

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Microbioz India, February 2023 | 8 Disclaimer: Neither the Microbioz India nor its publishers nor anyone else involved in creating, producing or delivering the Microbioz India (in printed, web or CD format) or the materials contained therein, assumes any liability or responsibility for the accuracy, completeness, or usefulness of any information provided in the Microbioz India Magazine (in printed, web or CD format), nor shall they be liable for any direct, indirect, incidental, special, consequential or punitive damages arising out of the use of the Microbioz India magazine. he imaging technique of diagnostic ultrasound, also known as sonography or diagnostic medical sonography, uses sound waves to create images of the internal organs and other structures in your body. A variety of diseases and ailments can be diagnosed, and treatment can be planned using the photos. While certain ultrasound exams require inserting a tiny device into your body, most ultrasound examinations use an ultrasound equipment that is outside of your body. The editors for Microbioz India are responsible for the cover story for this month, which is titled "5 Things to Consider Before Buying Ultrasound". Diagnostic ultrasound, commonly referred to as sonography or diagnostic medical sonography, is a type of imaging that uses sound waves to produce images of bodily structures. Sonography and diagnostic medical sonography are two additional terms for diagnostic ultrasound. The scans can offer valuable information that can be used to identify a variety of illnesses and disorders and target treatment at particular places. The applications for which an ultrasound system will be utilised, in addition to the available budget, must be carefully considered while choosing one. Certain elements will be decided upon in accordance with the applications. A feature story titled "Ultra-High Frequency digital mobile X-Ray solution”. Covered by BPL Medical Technologies" is included in the issue. The BPL M-Rad 5.0 DR is an ultra-high-frequency digital mobile X-ray solution that combines a distinctive design with superior image quality at low radiation dosage, making it ideal for patient wards, intensive care units, operating rooms, and other environments. BPL Medical Technologies is an Indian multinational that leads pioneering efforts in medical technology and innovation. Dear subscribers, there is nothing better than having your constructive criticism and recommendations because they enable us to consistently produce far better content. Please send an email to [email protected] if you have any recommendations or comments.

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Microbioz India, February 2023 | 10 5 Things to Consider Before Buying Ultrasound he utilisation of sound waves to create images of the inside of the body is what ultrasound imaging is all about. It is used to examine an unborn child (sometimes called a foetus) in pregnant women and can assist detect the reasons of discomfort, swelling, and infections that occur in the body's internal organs. When examining an infant's brain, hips, and spine, medical professionals frequently employ ultrasound technology. Also, it assists in the guiding of biopsies, the diagnosis of heart problems, and the evaluation of damage after a heart attack. The use of ultrasound is risk-free because it is not intrusive and does not involve the use of radiation. The preparation for this surgery is minimal, if not entirely optional. Your physician will give you instructions on how to be ready, including whether or not you should avoid eating or drinking before the procedure. Leave your jewellery at home and dress in comfy clothes that are loose fitting. It is possible that you will need to change into a gown. Diagnostic ultrasonography, also known as sonography or diagnostic medical sonography, is a form of imaging that creates images of structures within the body by using sound waves. Other names for diagnostic ultrasound include sonography and diagnostic medical sonography. The scans can provide useful information that can be used for identifying a number of diseases and ailments and directing treatment towards specific areas. T Cover Story

Microbioz India, February 2023 | 11 The vast majority of ultrasound examinations are performed by placing a device that emits ultrasonic waves outside of your body; but certain ones require inserting a small device into your body. What exactly does it mean when people talk about general ultrasound imaging? The images are presented in thin, horizontal portions of the body when using conventional ultrasound technology. Ultrasound technology has advanced to the point where it is now possible to do three-dimensional (3-D) ultrasound, which converts the sound wave data into images that are threedimensional. An ultrasound exam could also include a Doppler ultrasound study as one of its components. Doppler ultrasonography is a specialised form of ultrasound that can evaluate the movement of materials within the body. The physician is able to observe and assess the flow of blood via the arteries and veins of the body thanks to this tool. There are three distinct varieties of Doppler ultrasounds, which are as follows: Power Doppler is a more recent technique that is more sensitive than colour Doppler and is capable of providing greater detail of blood flow, particularly when blood flow is little or minimal. Color Doppler: employs a computer to convert Doppler measurements into an array of colours in order to display the speed and direction of blood flow through a blood vessel. Color Doppler was developed in the 1970s. Power Doppler, on the other hand, does not assist the radiologist in determining the direction in which the blood is flowing, which in certain circumstances could be extremely essential. Spectral Doppler: Rather than displaying the data as a colour picture, Spectral Doppler presents the results of its measurements of blood flow in a graphical format that expresses the data in terms of the distance travelled per unit of time. In addition to this, it is able to transform information on blood flow into a unique tone that can be heard in conjunction with each and every heartbeat. Cover Story

Microbioz India, February 2023 | 12 While selecting an ultrasound system, it is very necessary to take into consideration the applications for which it will be used, in addition to, of course, the available budget. Some aspects will be established based on the applications. I will now go over the top five things that you need to think about before purchasing an ultrasound machine. What purposes do diagnostic or screening procedures serve? In obstetrics, gynaecology, cardiology, vascular investigations, abdominal studies, anaesthesia, breast, neck, skin, and other tiny parts, ultrasound machines are utilised for diagnostic imaging. Obstetrics: Throughout pregnancy, ultrasound machines are used to monitor the development of the foetus. Gynecology: Ultrasound equipment are widely utilised for other women's health-related issues in addition to pregnancy-related imaging. Cardiology: Echocardiography is frequently used to assess the heart's general health. Blood vessels: Ultrasonography is helpful in identifying issues with the majority of the body's main blood vessels. The movement of the blood through the veins can be seen and measured using Doppler ultrasonography technology. Abdominal structures: The ultrasound equipment is most frequently used to examine the internal organs of the abdomen, including the liver, gallbladder, pancreas, kidneys, and bladder. Testicular torsion, epididymitis (testicle infection), and testicular masses are diagnosed using ultrasound. Thyroid and parathyroid gland nodules, growths, and tumours are also found using ultrasound, which is also used to image the breasts and guide biopsy of breast masses in order to screen for breast cancer. Which components and software are essential, and what are they? After determining the use or application for which the care and expected standards are intended, the next step is to determine the specific elements that are crucial to the care. Many different features and pieces of software, such as 3D/4D, Doppler studies, Auto IMT for vascular (which helps automatically measure the intima), Speckle reduction imaging or advanced speckle reduction imaging, spatial compound imaging, elastography, and so on, are all examples of things that could improve diagnostic ability. The game begins in a 2D mode by default. It is a two-dimensional cross-sectional view of the structures or organs that are being photographed, and it is composed of a great number of B-mode scan lines. This mode is enough for evaluating all organs and structures, including the assessment of the dimensions of the cardiac chambers and the structures of the valves, among other things. On the other hand, it is not very good at resolving quick movements. The minimum required level of training to operate the machine Before making a purchase, it is important to think about the degrees of experience held by the technicians who will be operating the new ultrasound equipment. It's possible that some additional instruction is going to be necessary before the equipment can be used effectively. It's probably a good idea to find out whether the company that sells the ultrasound machine offers classroom or virtual instruction. Onsite training is another possibility; however, there will be an additional fee associated with this choice. Duration of the warranty, service contracts, and availability of technical assistance Be sure to research the length of the manufacturer's warranty before investing in your next ultrasonic scanner. It tends to vary from one manufacturer to another. After the warranty has run its course, there is still the matter of service conditions and the terms of the contract to take into consideration. Verify the following items: 1. The length of the service contract 2. Any auto-renewal terms 3. Cancellation fees 4. Guaranteed response times 5. Preventive maintenance 6. Parts 7. Costs Another component of your acquisition that you must not overlook is the availability of technical support. During the process of completing your purchase, make sure you set aside some time to negotiate different options for system upgrades and technical support. Cover Story

Microbioz India, February 2023 | 13 As a result of the fact that they are frequently packaged into the terms and conditions, it is important that you make sure you obtain the greatest bargain possible. Determine the primary characteristics: You need to be on the lookout for particular technological specifications when you are purchasing the ultrasound machine. Consider keeping an eye out for the following characteristics: Frequency: The frequency of the ultrasonic machine is inversely proportionate to the depth to which the waves will penetrate. The higher the frequency, the deeper the waves will go. As a general rule of thumb, imaging will be more superficial when the frequency is greater (10-16 MHz), while penetration will be deeper when the frequency is lower (1 or 2 MHz). Power output: It is recommended to use machines with lower power settings since higher power output might cause burns to the tissues or epidermis. Power output is a significant component, and it is recommended to use machines with these settings. Imaging, CW Doppler, a DICOM system, a 3D/4D option, and colour Doppler are some of the other features that you should be on the lookout for. There are also many newer features, such as HDLive, Matrix, and Live 3D Echo. References: 1. Aldrich, John E. (May 2007). "Basic physics of ultrasound imaging". Critical Care Medicine. 35 (Suppl): S131– S137. doi:10.1097/01.CCM.0000260624.99430.22. P MID 17446771. S2CID 41843663. 2. ^ Postema M (2011). Fundamentals of Medical Ultrasonics. London: CRC Press. doi:10.1201/9781482266641. ISBN 97804291 76487. 3. ^ The Gale Encyclopedia of Medicine, 2nd Edition, Vol. 1 A-B. p. 4 4. ^ Jump up to:a b Cobbold, Richard S. C. (2007). Foundations of Biomedical Ultrasound. Oxford University Press. pp. 422–423. ISBN 978-0- 19-516831-0. 5. ^ Postema M, Kotopoulis S, Jenderka KV (2019). "Physical principles of medical ultrasound". In Dietrich CF (ed.). EFSUMB Course Book (PDF) (2nd ed.). London: EFSUMB. pp. 1– 23. doi:10.37713/ECB01. S2CID 216415694. Cover Story

Microbioz India, February 2023 | 14 Digital Mobile Radiography System PL Medical Technologies, an Indian multinational that leads pioneering efforts in medical technology and innovation, introduces the BPL M-Rad 5.0 DR, an Ultra High Frequency digital mobile X-Ray solution that combines unique design and superior image quality at low radiation dosage, making it ideal for patient wards, intensive care units, operating rooms, and other environments. Advanced Features: • Ultra-High frequency X-Ray generator: The system is equipped with a 110 kHz high frequency generator that produces lower skin dose. • Concealed Cable Design: For hygienic advantages in hospital environment. • Focus Scintillator Technology: FOCUS (Fluorescent Optical Csi Upgraded Structure) has more focused optical signal compared to conventional Csi. As a result, ultra-low noise is achieved by FOCUS technology. • IGZO Panel: IGZO Technology has 10 times faster electron mobility combined with lower leakage current compared to less-advanced TFTs. As a result, the IGZO TFT Technology has improved resolution by Ultra Noise reduction. • Pre-imaging processing by TRUVIEW®ART MTF performance provides better understanding of the image quality. Higher MTF value correlates with increase in image sharpness. TRUVIEW®ART increases MTF performance of indirect type (CsI) by removing the light scatter improving the image sharpness. • Post-imaging processing - DEPAI™AI DEPAI (Definition Enhancement Processed Advanced Imaging) AI algorithm, EVS series by QX platform has 2.5 X higher visibility and improved detectability for micro-abnormalities. • Internal Storage: For Stand-alone uses 100 Images can be stored inside detector’s memory. • Dust & Waterproof IP 54 Designed to prevent the infiltration of liquids, there is no need to worry for fluids such as blood or liquid could enter the device. Advantages of BPL M-Rad 5.0 DR 1. For Patient – Comfortable bed side Xray at a lower dose 2. For Technician – Smooth workflow with ease of positioning 3. For Radiologist – Fast and accurate diagnosis 4. For Administrator – High patient throughput About BPL Medical Technologies: BPL Medical Technologies, the Indian multinational, spearheads pioneering efforts in medical technology and innovation, keeping with legacy since 1967. Synonymous with trust, our products and systems are certified by national and international quality agencies. With our commitment to making in India, we help you experience great quality at unparalleled value. Our high standards of product performance have made us the no.1 choice of hospitals, clinics, and practising physicians across the country.BPL Medical Technologies Private Limited is a trusted company that provides reliable products and dependable service to its customers. Our products manufactured in an 13485: 2016 certified facility conform to global standards of quality assurance and best practices. BPL carries its legacy as the first Indian company to manufacture ECG devices in India. Today, the company has evolved to be one of the largest Indian Medical Device companies, offering a wide range of healthcare solutions in six segments namely Cardiology, Critical Care & Surgery, Women & Child Care, Imaging, Homecare and Consumables & Accessories. B Featured Article

Microbioz India, February 2023 | 15 The ultrasound machine at the hospital is collecting dust because there is no radiologist ollowing the departure of the radiologist who previously worked there, an ultrasound machine that had been recently installed at this location's 200-bed Civil Hospital has been sitting in an inoperable state for the past year. In this specialist hospital, patients coming from the Nurpur, Indora, Jawali, and Bhatiyat Assembly constituencies are having trouble getting the tests they need done. Patients are compelled to go to private laboratories in Pathankot (Punjab), Jassur, and Nurpur in order to have the test because the state Health Department has been unable to either appoint a radiologist or make other arrangements. The ultrasound examination is provided at no cost by public hospitals, however commercial laboratories often charge between Rs 700 and Rs 800 for it. In addition to this, patients are responsible for covering their own transportation costs. The most vulnerable patients are expectant mothers who are forced to go through with the examination. Free clinical testing, including an ultrasound of pregnant mothers, is provided as part of the Janani Shishu Suraksha Program, which is funded and administered by the central government. The fact that the hospital does not currently have a radiologist on staff has had a significant negative impact on this programme. Women who are pregnant are expected to pay the exorbitant prices charged by private facilities for ultrasound exams. When patients go to private clinics or laboratories for their ultrasound scan, they are expected to shell out a considerable sum of money. The locals have requested that the hospital hire a full-time radiologist to staff the facility. They have also requested that the authorities make at least a temporary arrangement for a radiologist to be on deputation twice or three times every week. According to the findings of some investigations, the positions of radiologist and radiographer at the Jawali public hospital have both been unfilled for the previous few years. From the beginning of the last three years, the hospital's imaging department has not performed any X-rays, and in recent months, they have also stopped performing ultrasound exams. The Medical Superintendent of the hospital, Dr. Sushil Sharma, stated that he had communicated with the higher authorities regarding the open position of radiologist. He acknowledged that there is a severe lack of radiologists working for the Health Department. F Featured Article

Microbioz India, February 2023 | 16 GE HealthCare to Acquire Caption Health, Expanding Ultrasound to Support New Users Through FDACleared, AI-Powered Image Guidance 1. Acquisition supports GE HealthCare’s $3 billion Ultrasound business by adding AI-enabled image guidance to ultrasound device portfolios 2. Helps enable affordable, convenient access to point of care ultrasound imaging for a variety of clinical uses 3. Acquisition aligns with strategy to deliver precision care and expands access to new ultrasound users and clinical uses E HealthCare (Nasdaq: GEHC), a leading global precision care innovator, announced that it has signed an agreement to acquire Caption Health, Inc., a privately-owned artificial intelligence (AI) healthcare leader that creates clinical applications to aid in early disease detection, using AI to assist in conducting ultrasound scans. With Caption AI applications, ultrasound examinations can be easier and faster, enabling a broader set of healthcare professionals to conduct basic echocardiogram exams. This technology can help detect signs of diseases like heart failure in at-risk patients across doctors’ offices, the home, and alternate sites of care, potentially preventing hospitalizations and supporting improved clinical outcomes. GE HealthCare Ultrasound President and CEO Roland Rott said, “Guiding ultrasound users during examinations with the help of AI is of growing importance, especially as we reach a broader set of healthcare professionals. Caption Health’s AI applications help enable reliable, consistent ultrasound examinations to deliver more precise diagnoses, improved treatment decision-making, and ultimately improved patient outcomes. This tuck-in acquisition will help expand affordable access to ultrasound imaging to novice users and is aligned with a broader shift to precision care globally.” Caption Health CEO Steve Cashman said, “We are incredibly proud of the technology we have built and together with GE HealthCare, look forward to bringing this technology to more patients across the globe. Combining our AI applications with GE HealthCare’s ultrasound devices will help accelerate our mission to detect disease earlier, when an easily obtained diagnostic image can be a great equalizer to health quality and outcomes. This will ultimately help us reduce costs and enhance care.” Heart ultrasound examinations are the primary tool used to help identify heart failure, the most common diagnosis in the U.S. for hospitalized patients over the age of 651 . It contributes to millions of deaths globally every year, but early symptoms like fatigue or shortness of breath are commonly confused for normal signs of aging2 . G Featured Article

Microbioz India, February 2023 | 17 A study showed that 38% of new heart failure patients are diagnosed in acute care facilities, even though 46% of these patients had potential symptoms six months before diagnosis, when intervention would have had a greater impact in slowing disease progression3 . Doctors call heart failure "the silent killer" because it is so easy to ignore symptoms until it is too late. It has remained a leading cause of death nationwide4 , with cases on the rise following the COVID pandemic5 . Karley Yoder, Chief Digital Officer, Ultrasound at GE HealthCare, who will integrate Caption Health into the broader digital ecosystem of GE HealthCare, said, “We couldn’t be more excited to partner with the Caption Health team to increase access and accelerate growth of ultrasound. Caption Health will first be integrated in the Point of Care and Handheld business portfolio to advance ultrasound adoption, with expanded future use cases as well.” As part of this acquisition, Caption Health will continue to provide management and administrative services to affiliated medical services providers (collectively referred to as “Caption Care”). By providing trained technicians across the country equipped with the Caption Health AI technology to perform cardiac ultrasounds in alternate sites of care and, in the future, in the comfort of patient’s homes, Caption Care service is intended to support early diagnosis and detection before diseases like heart failure become more difficult to treat. Caption Health also has a strong development pipeline of AI software, including innovative technology for the use of ultrasound in pulmonary applications. The consummation of the transaction is subject to customary closing conditions. Financial terms of the transaction are not being disclosed. GE HealthCare intends to fund this transaction with cash on hand. About GE HealthCare Technologies Inc. GE HealthCare is a leading global medical technology, pharmaceutical diagnostics, and digital solutions innovator, dedicated to providing integrated solutions, services, and data analytics to make hospitals more efficient, clinicians more effective, therapies more precise, and patients healthier and happier. Serving patients and providers for more than 100 years, GE HealthCare is advancing personalized, connected, and compassionate care, while simplifying the patient’s journey across the care pathway. Together our Imaging, Ultrasound, Patient Care Solutions, and Pharmaceutical Diagnostics businesses help improve patient care from prevention and screening, to diagnosis, treatment, therapy, and monitoring. We are an $18 billion business with 50,000 employees working to create a world where healthcare has no limits. About Caption Health Caption Health is the AI leader that provides heart ultrasound access for early disease detection – when there is the highest potential for impact. The company's Caption Care services offer health providers, payers, and value-based care organizations convenient and cost-effective echos for their members, leveraging its Caption AI technology platform. In 2021, Caption Health was recognized as one of TIME's 100 Best Inventions and a winner of Fast Company's Next Big Things in Tech for health. Caption Health's platform is used at leading hospitals, clinics, and physician organizations, and is cited in several peer-reviewed journals including JAMA Cardiology and Journal of the American Society of Echocardiography. For more information, visit captionhealth.com. ___________________________________ 1 Emory Healthcare, Heart Failure Statistics, 2022 2 https://hfsa.org/patient-hub/heart-failure-factsinformation 3 Sandhu, A. et al. (2021). Disparity in the Setting of Incident Heart Failure Diagnosis. (Circulation: Heart Failure) 4 https://www.cdc.gov/heartdisease/facts.htm 5 https://www.thelancet.com/journals/eclinm/article /PIIS2589-5370(22)00349-2/fulltext Featured Article

Microbioz India, February 2023 | 18 5 Stand-out Features of SEFAM Sleep Apnea Treatment Devices You Should Know he Obstructive Sleep Apnea Syndrome (OSAS) is distinguished by recurrent episodes lasting at least ten seconds each in which the upper airway is blocked off while the patient is sleeping. Either the upper airway is completely blocked (apnea), or only a portion of it is (hypopnea). These episodes, which can occur as often as several hundred times throughout the course of sleep, frequently result in micro-arousals, which significantly degrade the calibre of sleep that an individual receives. Snoring is almost always present when a patient has apnea or hypopnea, and these breathing disorders place a significant amount of strain on the cardiovascular system. If it’s not treated, sleep apnea can cause a number of health problems, including hypertension (high blood pressure), stroke, cardiomyopathy (enlargement of the muscle tissue of the heart), heart failure, diabetes and heart attacks. Untreated sleep apnea can also be responsible for job impairment, work-related accidents and motor vehicle crashes, as well as underachievement in school in children and adolescents. Symptoms: The most common signs and symptoms of OSA include: 1. Snoring. 2. Daytime sleepiness or fatigue. 3. Restlessness during sleep, frequent nighttime awakenings. 4. Sudden awakenings with a sensation of gasping or choking. 5. Dry mouth or sore throat upon awakening. 6. Cognitive impairment, such as trouble concentrating, forgetfulness or irritability. 7. Mood disturbances (depression or anxiety). 8. Night sweats. 9. Frequent nighttime urination. 10. Sexual dysfunction. 11. Headaches. Treatments: Treatment by continuous positive airway pressure (CPAP) is currently the most effective treatment of OSAS, as its benefits largely outweigh the drawbacks. CPAP consists in blowing air in the airway to restore normal breathing and sleep patterns during the night using a nasal or a full-face mask which is connected via a tube to the device. After prescription, the CPAP device is put in place by a home healthcare provider, who plays a key role in patient adherence to therapy and education about the treatment. As of the first night of treatment, apneas and hypopneas disappear, leading to improved quality of sleep and gradually eliminating difficulties in the patient’s daily life. Improved sleep quality and fewer day-to-day challenges are reported by patients after just one night of treatment. When the sleep apnea issue is not too severe and the patient does not suffer from serious cardiovascular diseases, a mandibular advancement device (MAD) is an alternative therapy advised. The lower jaw and tongue are held in a forward position by this dental appliance. In extremely unusual instances, surgery may be required to correct abnormalities in bone morphology. I've compiled a list of the top 5 features of SEFAM's sleep apnea devices to share with you now. Sefam DreamStar Auto: Capable of detecting and distinguishing between respiratory events, DreamStar Auto automatically adapts the treatment pressure depending on the type and severity of the events. One year of summary compliance data and the last 16 hours of actual flow data are saved into the device’s memory and available for analysis with the DreamStar Analyze software. DreamStar Auto operates in CPAP and AutoCPAP modes. In its Auto-CPAP mode, DreamStar Auto automatically adjusts the pressure as a function of the severity of the detected respiratory events (apneas, hypopneas, inspiratory flow limitations, snoring). T Featured Article

Microbioz India, February 2023 | 19 Sefam Ecostar, Ecostar Info, Ecostar Auto: The different models in the EcoStar range have inherited technologies from DreamStar and world-famous GoodKnight range. These continuous positive airway pressure devices combine simplicity, reliability, and economy. EcoStar (CPAP) is about simplicity without compromising performance featuring unmatched pressure stability. With its basic configuration EcoStar (CPAP) is a very economic and efficient PAP device. EcoStar With the default settings, Ecostar provides a fixed pressure and compensates for leaks and variations in atmospheric pressure due to altitude. EcoStar provides excellent pressure stability. For more information: Customer Service | India T : +91 777 8910 601 E : [email protected] Customer Service | France T: +33 (0)3 83 44 85 50 E: [email protected] About Sefam: Since it was founded in 1982, the Nancy-based French company Sefam has been designing, manufacturing, and commercializing diagnostic and therapy devices for Sleep disordered Expertise: Proud of our history and our 30 years of experience, we put all our expertise at the service of our patients. We are constantly looking to improve our solutions, to create even more accurate and personalized cutting-edge technology. Sefam places a great deal of importance on feedback from customers, doctors, distributors and home healthcare providers, because only by working together the perfect solutions can be derived to achieve a common goal: to improve the health of patients. The Medical Advisory Board, guides Sefam. Thus, the products and services are inspired by doctors and researchers. Sefam has all the necessary quality certifications (ISO 9001, EN 13485, FDA, etc.) demonstrating quality and safety of our devices. Featured Article

Microbioz India, February 2023 | 20 Wearable ultrasound tech coming soon with accurate real-time heart scans earable technology has come a long way in recent years with a wide range of devices now available to monitor everything from our fitness levels to our sleep patterns. For those who suffer from heart conditions, heightened anxiety, or who simply want to keep track of their health conditions, a new wearable ultrasound patch will be available soon that can revolutionise how we monitor our heart health. The device is a small patch that can be worn on the skin and uses ultrasound technology to scan the heart in real-time. The patch is designed to be worn on the chest, and it uses a small ultrasound probe to capture images of the heart as it beats. The images are then analyzed by the device's software, which can detect any abnormalities or issues with the heart's function. One of the biggest advantages of this technology is that it allows for real-time monitoring of the heart, which means that any issues can be detected and treated much sooner than with traditional diagnostic methods. This is particularly important for people who are at risk of heart disease, as early detection can greatly improve the chances of a successful outcome. The researchers at the University of California-San Diego are now working on further developing the technology and making it more user-friendly. They are also exploring the possibility of integrating the device with other wearable technologies, such as fitness trackers, to create a more comprehensive health monitoring system. Past attempts at wearable ultrasound arrays have relied on thin metal films that limit the design's complexity. Another advantage of the device is its portability and ease of use. Unlike traditional ultrasound machines, which are large and bulky, the patch is small and lightweight, making it easy to wear and use on the go. W Business News

Microbioz India, February 2023 | 21 This means that it could be used in a variety of settings, including at home, at work, or even while travelling. “The technology enables anybody to use ultrasound imaging on the go,” says project leader Professor Sheng Xu in a media release. The wearable ultrasound patch is a promising new technology that has the potential to greatly improve the way we monitor and diagnose heart disease. With its real-time monitoring capabilities and portability, it could become an essential tool to monitor body statistics for athletes too. “The device can be attached to the chest with minimal constraint to the subjects’ movement, even providing a continuous recording of cardiac activities before, during and after exercise,” postdoctoral researcher Xiaoxiang Gao said. At the moment, the patch is still in the development stage, but the hope is that it will be available to the public in the near future. In the meantime, the researchers are working to refine the technology, making it smaller and more precise. The team is also working to develop compatible software so that the data collected can be easily accessed and shared with healthcare providers. The device could offer a more direct way to monitor heart health, allowing people to receive treatment quickly before their condition worsens. If successful, this could be a major breakthrough in the field of cardiac care, offering those with heart conditions a greater level of independence and peace of mind. Business News

Microbioz India, February 2023 | 22 Precision Oncology and personalized medicine orld Cancer Day is being observed on February 4th every year from the Year 2000. Started by Union for International Cancer Control (UICC) to campaign and spread awareness about cancer by adopting, different themes every year, in 2022 UICC called for a 3-year campaign for impact and chose a common theme for years 2022-2024: Close the care gap. The first year 2022 was about recognizing the inequities in cancer care around the globe, question the status quo, help reduce stigma, listen to perception of people living with cancer so that their experience guide our thoughts and actions, in such a way that we begin to imagine a better way of doing things and build a fairer vision of the future. The 2nd year for this campaign is about uniting our voices with like minded people and taking action step by step towards achieving our dream of a cancer free World. On this world cancer day, I would like to bring to your notice the 5 major scientific milestones which have made a huge impact in care for cancer in the past decade. I. Immunotherapy: This is definitely one of the path breaking discoveries in the past decade. Tumors grow in our body by evading / misleading our immune system. This therapy brings back the cancer under the radar of our immune System and increases the effectiveness of other therapies in turn providing longer periods of remission. Significant impact has been seen in many cancers especially Lung cancer. II. Next Generation Sequencing: Massive Parallel Sequencing of tumor DNA / RNA to detect specific mutations in the genome which could have been the cause of his / her cancer. Once a mutation is detected, we also get to know if this is hereditary and if is there is any drug which can target this mutation. This makes Cancer treatments more personalized. BRCA gene testing in breast and ovarian cancers, EGFR, ALK, Ros testing in lung cancers, MSI testing in colonic and many other cancers are examples. III. Targeted Therapies: These medicines are a direct consequence of our ability to delineate targets in individual tumors through various molecular teste including Next Generation Sequencing. Most of the targeted therapies come in tablet form which makes administration very easy for the patients and avoids multiple chemotherapy injections. IV. PROTON Therapy: The therapies previously discussed are either tablets or injections. This therapy is a form of Radiation therapy. Conventional Radiation therapy Consists of Photons generated at Mega voltage to treat cancers. In proton therapy particles called Protons are used instead of photons to improve precision and decrease side effects and Apollo is the first hospital to introduce it in India. This is most useful in treating tumors which are nearby critical organs like brain and spinal cord. W Hospital Watch

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Microbioz India, February 2023 | 24 V. Developments in supportive care: Array of new Medicines have come up in the last decade which are much more effective in tackling nausea and vomiting associated with chemotherapies. Scalp cooling machines are available which prevent hair loss for patients on chemotherapy. Various interventions from Radiology and Pain Medicine have made treatments more tolerable and the journey of fight against cancer more comfortable than ever before. Dr Srinath Bharadwaj Consultant Medical Oncology, Apollo Hospitals, Jubilee Hills. CANCER IS PREVENTABLE - 4th Feb - World Cancer Day very year in India 1.39 million new cancer cases are detected. By 2025 the annual incidence of cancer in India is projected to be 1.5 million. Every year 8.5 lakh patients die due to cancer in India. This makes cancer a big problem. There are both non modifiable risk factors in the form of gene associated and familial cancer and modifiable risk factors which may predispose to cancer. With latest advances in health care practice, many of these cancers are curable if they are detected in early stages. Around 45% of cancers arise mainly from oral cavity, breast, female reproductive system, lung, stomach. These cancers are mainly caused by many modifiable risk factors like tobacco consumption, alcoholism, lifestyle problems, social factors, and also infections like human papilloma virus. Worldwide cancer prevention strategies focus on these modifiable risk factors through primary prevention and secondary prevention. Primary prevention involves the avoidance of risk factors that may cause cancer. This includes cessation of smoking, reduced consumption of alcohol, healthy lifestyle changes, vaccination against Human Papilloma virus. Diet plays a major role in cancer prevention. American Institute of Cancer research (AICR) recommends Low alcohol, Low Calorie, Low fat, High dietary fibre, Low red meat and Low processed meat in diet for prevention of cancer. Government of India in 2003, passed Cigarettes and other tobacco products act (COTPA act) which prohibited advertisement of tobacco products, smoking in public places, sale of tobacco products near educational institutions and also mandated depiction of statutory warnings on tobacco packs and tar and nicotine contents along with maximum permissible limits on tobacco pack. Human Papilloma virus infection is the most common cause of cervical cancer in women. Various vaccines are developed in bivalent, quadrivalent and nanovalent forms providing protection against human papilloma virus infection. 80% of cervical cancers can be prevented with HPV vaccination to girls between 9-14 years of age. Government of India launched first Indigenous Cervical vaccine which is a quadrivalent vaccine in September 2022 thereby reducing the cost burden of vaccination on individuals. As per NTAGI recommendation, cervical vaccine is expected to be integrated into the Universal immunisation schedule for girls aged between 9-14 years of age. E Hospital Watch

Microbioz India, February 2023 | 25 Apart from the Government initiatives as an individual one should have a knowledge on the life style risks that can lead to cancer such as habits, sedentary life styles, avoidance of breast feeding etc. A personal change to lead a healthy lifestyle will protect a person from cancer to some extent. Secondary prevention includes regular screening of most common cancers, to facilitate the diagnosis of cancer in a early stage thereby increasing the chances of cure. Government of India under National Programme for Prevention and control of Cancer, Diabetes, Cardiovascular diseases and Stroke (NPCDDCS) mainly focusses on prevention strategies in form of health education regarding hazards of tobacco consumption, necessity of genital hygiene and also launched various screening programmes in regional cancer centres for ca cervix, breast and oral cancer. As a person its important to know the presence of any history of cancer in the family, identifying the risk of cancer in self and also undergoing regular screenings accordingly. For women, screening for cervical cancer starts at age of 21 years in form of pap smear and breast cancer starts age of 45 years in form of self-breast examination, mammograms, physical examination. Regular health check-ups for any ulcers in oral cavity or any bowel disturbances will help in diagnosing oral cavity cancer and colorectal cancer early. For men above 50 years a blood test in form of PSA will help in screening for prostate cancer. However, Prevention is always better than cure. A healthy lifestyle with proper precautions will help in preventing many cancers to an extent. Author: Dr. P. Vijay Anand Reddy Director, Apollo Cancer Centre, Apollo Hospitals, Hyderabad. Yes, CANCER can happen in the EYES also! 1. It can occur in newborns, in children and in adults 2. Raising awareness about Eye Cancer on the World Cancer Day - 4 th February th February is observed as the ‘World Cancer Day’ to raise awareness about Cancer - one of the leading causes of deaths worldwide. Cancer is a large group of diseases (affecting various parts of the body) and occurs when the normal cells become cancerous cells and multiply and spread, resulting in formation of a mass called a tumour. Awareness about eye cancer among the public is low - few are aware that cancer can happen in the eyes also. Eye Cancer is a generic term used to explain many types of cancer or tumours that form in the tissues in and around the eye or in the exterior parts of the eye, such as the eyelid or conjunctiva (the thin-clear membrane that protects our eyes). It can occur in newborns, in children and in adults. 4 Hospital Watch

Microbioz India, February 2023 | 26 “Among all forms of cancers, the incidence of eye cancer is estimated to be low. But it can result in loss of life and vision. It is curable if the tumour is detected early. Spreading awareness will help in the early diagnosis and appropriate treatment of eye cancer, thus saving life and vision of a person. Whenever we are treating a patient with cancer, there are three goals that we want to achieve - first, save the life; second, save the eye; and third, save the vision of the patient. Despite our best efforts to save a life in a significant percentage of patients, eye removal surgery is required. Generally, this is because the patient comes to us at an advanced stage. Eye cancer can also spread from one eye to the other eye or to other parts of the body if not diagnosed early and treated appropriately,” says Dr Swathi Kaliki, Head, Operation Eyesight Universal Institute for Eye Cancer, L V Prasad Eye Institute. “Certain eye cancers may be related to smoking, virus infection and excessive exposure to ultraviolet light. They are unlikely to be related to food habits. Certain cancers can be inherited from affected family members, and those at risk should undergo screening with an eye cancer specialist. While most eye cancers cannot be prevented, it is important for individuals with family history of eye cancer to undergo routine eye screening so that the disease can be detected early and treated appropriately. For those without any family history of eye cancer, if they notice any swelling/lesion (lump) in the eyelids or on the surface of the eye or forward protrusion of the eyes or experience decreased vision, they should go for an eye examination without delay” adds Dr Kaliki. Different kinds of Eye cancer: 1. Eyelid Tumours - arising on the eyelids or eyebrow region 2. Conjunctival Tumours - on the surface of the eye 3. Corneal Tumours - on the front surface of the eye 4. Orbital Tumours - occurring behind the eye and pushing the eye forward 5. Intraocular Tumours - occurring inside the eye in the region of the iris, retina, optic disc, etc Symptoms: 1. Bulging of the eye 2. Swollen eyelids or a lump in the eyelid that is increasing in size 3. Disproportion in the size of the two eyes 4. White reflex in the eye 5. Occurrence of a dark patch in the eye that is getting bigger in size 6. Squint 7. Redness or pain 8. Blurred vision or partial or total vision loss These symptoms can also be caused by other minor or major eye problems and not necessarily a sign of eye cancer alone. But as soon as you notice these symptoms it is important to get your eyes checked by a doctor and seek timely treatment and care. It is important to be aware about these symptoms that otherwise could be easily dismissed as an infection. Treatment The treatment of cancer depends on the stage at which the patient presents. Different forms of therapy are available. For smaller tumours, medical therapy or laser would suffice. Large tumours may need surgery, while aggressive tumours need removal of the eye and tumour along with chemotherapy and sometimes even radiotherapy. Over the past ten years, L V Prasad Eye Institute, across its network centres, has treated over 25,000 cases of various forms of eye cancer. The Operation Eyesight Universal Institute for Eye Cancer is a dedicated facility for Eye Cancer at the L V Prasad Eye Institute. It offers comprehensive and advanced treatment for managing eye cancer in children and adults. The team is also actively engaged in research, education, training, and capacity building of eye care professionals. Hospital Watch

Microbioz India, February 2023 | 27 CritiCare Asia Hospitals Launched its Latest Release of Second Advanced Robot or the advancement in the Robotic Surgery, CritiCare Asia Group of Hospitals has launched an advanced third generation robot with features like bone movement monitoring and haptic feedback mechanism. After introducing the First, Third Generation Advanced Robot with Team Robodocs in Suburban Mumbai at Andheri East last year, CritiCare Asia Group of Hospitals is pleased to announce the introduction of its Second Advanced Robot to provide Robotic Assisted Total Knee Replacement Surgery at its recently inaugurated centre in Malad (West). This highly advanced technology system utilizes state-of-the-art AI, computer-assisted technologies and robotics to assist surgeons in complex procedures. Its advanced 3D visualization and intuitive control systems offer the best level of precision and control that has never been seen in surgery. With the help of this innovative technology, surgical procedures will be performed with a new degree of precision and accuracy, enhancing patient outcomes and the healthcare process as a whole. Team RoboDocs (Left to right): Dr Sanjay Londhe, Dr Aatish Shah, Dr Masuuma Namjoshi (Director), Dr Deepak Namjoshi (Founder), Dr Rakesh Nair, Dr Vijay Shetty, Dr Santosh Shetty, Dr Niraj Vora Dr Deepak Namjoshi, renowned Pulmonologist and Critical care specialist, founder and Dr Masuuma Namjoshi, Director, CritiCare Asia Group of Hospitals, Mumbai, who are committed to bringing the best in healthcare technology and make the hospital one of the best hospital for robotic surgery in Mumbai, expressed, “After operating on more than 175 happy patients in Suburban Mumbai in short period of time using Fully Active Automatic Robotic Arm Technology, CritiCare Asia Hospitals are making a significant step towards a future in which healthcare can be more effective, efficient, and available to everyone through robotic surgery.” In addition to the Robotic Assisted Surgery, Dr Deepak Namjoshi has also announced the joining force of Suburban Mumbai’s eight renowned hip and knee joint replacement surgeons to lay the foundation for CritiCare Asia hospitals “RoboCare” initiative - ‘A Robotic Joint Replacement Centre of Excellence’. These experts of CritiCare Asia Group of Hospitals, Dr Sanjay Londhe, Dr Santosh Shetty, Dr Rahul Deshmukh, Dr Kshitij Shah, Dr Akash Sarogi, Dr Amin Momin, Dr Kunal Patel and Dr Pratik Talekar having more than 100 years of experience and treating more than 10000 patients have come together to offer the best treatment to the patients suffering from knee pain and arthritis cumulatively. Dr Santosh Shetty, associated Robotic Joint Replacement Surgeon (Team RoboCare) of CritiCare Asia hospitals who also performed Mumbai's First Robotic Cruciate Retaining Joint Replacement Surgery said, "Robotic Joint Replacement Technology is a boon to patients suffering from arthritis wherein the surgical outcomes can be accurate and precise resulting in a painless recovery with a short stay in hospital and a speedy recovery. The traditional muscle-sparing techniques and ligament-sparing techniques where the muscles and ligament are not cut but rather saved, and now the latest cutting-edge robotic technology, which gives sub-millimeter accuracy while cutting the bones, are all adding excellent value to the overall results and recovery of the patients undergoing joint replacement." About CritiCare Asia Group of Hospitals CritiCare Asia Multispeciality Hospital & Research Center has been associated with the professional medical care of the highest caliber by experienced doctors for over two decades now and is located in the western suburb of Mumbai - Andheri East, Juhu, Malad West and Kurla, off BKC. F Hospital Watch

Microbioz India, February 2023 | 28 We are a group of highly skilled medical professionals from various fields who are proud of both their profession and the hospital's fundamental beliefs. We are pleased to be a family of more than 500 consultant doctors, 1,000 paramedics, and general employees with four hospitals and the principles of offering people topnotch, high-quality medical services with a humanitarian touch. With more than 650 plus beds and Mumbai's largest and most qualified team of robotic surgeons, we are one of the best in providing cutting-edge technology at a reasonable price with reliable results. Royal Care Super Speciality Hospital Dedicates India's First MRgFUS Technology to the Nation is Excellency, Mr. Naor Gilon, Ambassador of Israel to India, inaugurated and dedicated India’s first MRgFUS Technology to the nation in the presence of Dr. K. Madeswaran, Chairman and Managing Director, Royal Care Super Speciality Hospital, and other dignitaries in the city today. Royal Care Super Speciality Hospital, Coimbatore has set up India’s First MRgFUS (Magnetic Resonance Guided Focused Ultrasound Surgery) - a new technology for the treatment of Essential Tremors and Tremor Dominant Parkinson’s disease. His Excellency Mr. Naor Gilon, Ambassador of Israel to India, inaugurating and dedicating MRgFUS Technology to the nation in the presence of Dr. K. Madeswaran, CMD, Royal Care Super Speciality Hospital MRgFUS is a technology that has the potential to change the way movement disorders are being treated. Tremors have long been treated with various medications without significant benefit. For the treatment of essential tremors and tremordominant Parkinson’s disease MRgFUS is approved by the Central Drugs Standard Control Organization (CDSCO) which is a part of the Ministry of Health and Family Welfare of India. MRgFUS has also been approved by the US Food and Drug Administration (USFDA). According to Dr. K. Madeswaran, Chairman and Managing Director, of Royal Care Super Speciality Hospital, “The Royal Care Super Speciality Hospital is equipped with advanced medical equipment and technologies and has often been the first in introducing the latest innovations in the medical field to the country. The newest and the most advanced of them is the Magnetic Resonance Guided Focused Ultrasound for the treatment of essential tremors and tremor-dominant Parkinson's disease. This procedure is conducted by a team of highly qualified and experienced neurosurgeons and neurologists who have been specifically trained in the focused ultrasound technique to target sub millimeter areas in brain." Magnetic Resonance Guided Focused Ultrasound provides an incision-less treatment option for tremor-dominant Parkinson's patients who do not respond to medications. MRgFUS works under the principle of combining 2 technologies - Magnetic Resonance Imaging aids and Ultrasound. Focused ultrasound is a treatment option that provides tremor control without surgical incisions. During the treatment under MRI guidance, ultrasound waves are precisely focused on the small spot in the brain considered to be responsible for causing tremors. Low energy is first applied which allows the patient to inform the physician of any sensations they feel, decrease in tremors and other potential side effects, then the physician can make individualized adjustments to the target. The energy is gradually increased to create a small therapeutic lesion. MRI provides a high-resolution, complete anatomical survey of the treatment area which helps in designing patient-specific treatment planning. Its real-time thermometry monitors temperature changes thereby helping in adjusting the treatment target in real time. MRI gives intra-operative T2 weighted MR images to verify complete ablation. H Hospital Watch

Microbioz India, February 2023 | 29 At present, MRgFUS has been approved for the treatment of Essential Tremor and Tremor Dominant Parkinson’s disease in India. Many patients have reported an immediate improvement in tremors with minimal temporary complications. Over 3500 patients have been treated to date around the world. About Royal Care Super Specialty Hospital Royal Care Super Specialty Hospital is a 500 bedded ultramodern healthcare facility situated at Neelambur, Coimbatore, Tamil Nadu. With over 4,00,000 square feet of modern infrastructure, the hospital is equipped with all the necessary facilities to deliver comprehensive healthcare under one roof. With a commitment to making available facilities on par with the latest advances in the Western World, Royal Care Super Speciality Hospital was the first in the country to introduce Bronchial Thermoplasty for the treatment of severe asthma in selected patients. Royal Care is also the first hospital in the country to introduce the micro-plasma advanced oxidation for dialysis feed water disinfection to eliminate endotoxins and to prevent pyrogenic reactions in patients undergoing haemodialysis. Royal Care Super Specialty Hospital is a dependable destination for people seeking comprehensive healthcare. The hospital brings together highly talented medical professionals with phenomenal expertise in their respective fields, cutting-edge innovative diagnostic and therapeutic medical technologies, and friendly medical and paramedical staff to provide courteous and compassionate care with a personal approach. A Mental wellness app incubated by students at EdVenture Park will provide the platform n a first of its kind initiative, NGO Helping Hand Foundation that runs several Primary Health Care centers in collaboration with SEED-USA and mostly from 8 locations in the Urban Slums of the old city, launched a comprehensive mental health program for women from marginalised sections of the society in Old city. As per a survey done by HHF, most women in Urban slums of the Old city work as maids or domestic help. Typically, women supplement or sometimes are sole bread earners in families with average 3 to 4 children to feed. They not only work outside but must cook and feed the family after coming back. This coupled with poverty and poor nutrition takes a toll on physical & mental health of these women. Mental health is both a stigma and taboo in the old city. Mental health issues are poorly understood and addressed due to low awareness level and access to mainstream mental health services or treatment is very poor in the old city as per the survey done by NGO, Helping Hand Foundation. I Hospital Watch

Microbioz India, February 2023 | 30 The Primary Health Centre located in Masjid Mohammed Mustafa in Rajendranagar will be the first centre from which the program will start and will be rolled out to other 6 centers in due course. The primary health centers run by HHF, have been providing a wide range of health care services for the Urban Poor. The services encompass primary care, dental, Ophthal, mini trauma, ante, and postnatal care, apart from prevention of NCDs. Mental Health will be an added dimension into the primary health care setting for the clinics run by HHF in Urban slums of the city and this has been strongly advocated by WHO in the Universal Health Coverage model. HHF has tied up with GoodMind.app, a mental wellness platform incubated at EdVenture Park, India’s first student-focused startup incubator. GoodMind.app will provide a platform for mental health screening. HHF Counsellors trained in mental health will be doing the screening and the therapy or counselling for the patients that show signs of mental health issues will be done by qualified clinical psychologists from HHF and GoodMind.app. Many women and adolescents from weaker sections suffer from depression & anxiety disorders. Poverty, hardship in life, other health issues, matrimonial issues, domestic violence, and interpersonal family issues all add up to the situation and most need help said Ms. Saniya, Founder of GoodMind.app one of the partners in the program 30% of NCDs particularly diabetics and women with hormonal imbalances suffer from undiagnosed depression and anxiety as per survey done by NGO. The mental health screening app will evaluate a patient on a scale of 48 & will help the counsellor identify the signs and symptoms of the mental health condition of the patient. Scores between 0- 24 will be considered normal and 24-40 considered moderate and 40-48 severe. We are targeting to screen 100 patients each from each of our PHCs daily translating into 500 plus minimum and all cases of moderate to severe mental health will be counselled and treatment initiated wherever necessary said Mr. Mujtaba Hasan Askari, Helping Hand Foundation. Indian Association of Cardiovascular Thoracic Surgeons, confers the coveted ‘Lifetime Achievement Award’ to Padma Shri Dr. Prasada Rao! admashri Dr. Dasari Prasada Rao, former Director of Nizam Institute of Medical Sciences and Chairman, Nano Hospitals Pvt. Ltd.; was conferred the prestigious Lifetime Achievement Award by the Indian Association of Cardiovascular Thoracic Surgeons (IACTS) – the association of heart surgeons of India, at its 69th Annual Conference, held at Coimbatore. P Hospital Watch

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Microbioz India, February 2023 | 32 He was felicitated with the coveted award in recognition of his yeoman service and excellence in heart, lung and liver surgeries, spanning over four decades. Chief Guest Shri MA. Subramanian, Minister for Medical and Health, Tamil Nadu; Dr. Jail Singh Mehrwal, President, IACTS and Dr. C.S. Hairmath, Secretary, IACTS; other dignitaries and over thousand heart surgeons from pan India; graced the occasion. Dr. Prasada Rao earned enormous admiration and goodwill from his patients and professional peers alike, for his dexterity and expertise, on par with the best in the world, in the field of cardiothoracic surgery. He is acknowledged for his high standard of proficiency in performing coronary bypass surgeries, heart valve surgeries and other heart operations and won the gratitude of patients for being their life saver. During his tenure as the Director of NIMS Hospital, Hyderabad; he initiated several visionary measures including equipping the hospital with advanced facilities, construction of new building, setting up of state-of-the-art medical facilities like accident and emergency hospital, specialty Hospital, stem cell facility, bone marrow treatment etc. He upgraded NIMS and ensured it being counted among the best healthcare facilities in the country. He played an active role in acquiring 200 hundred acres of land for NIMS University at Bibi Nagar, which is currently shaping into the All-India Institute of Medical Sciences. As the founding director of Care Group of Hospitals, Mediciti Hospital, he contributed significantly to their transformation into centers of excellence. He was awarded the Padma Shri in 2001 along with many other awards for his multi-faceted services. Dr. Prasada Rao is currently serving as the Chief Cardiac Surgeon at Apollo Spectra Hospital, Ameerpet, Hyderabad. Oasis Fertility, Kurnool conducts Mass Baby Shower to felicitate couples who conceived through IVF! nfertility is becoming a major concern in India due to erratic lifestyles, consumption of junk food, obesity, delayed parenthood, PCOS, and many other factors. Though 15% of Indian couples have infertility issues, hardly 3% seek fertility assistance. The misconceptions about infertility and the lack of awareness of advanced fertility treatments prevent couples from attaining parenthood. Hence, spreading the good news about advanced technologies and treatment options is the need of the hour. Oasis Fertility, Kurnool, is one of the reputed fertility centres in Andhra Pradesh that offers highly personalized fertility treatments that are backed by technology. Several couples have attained parenthood with the assistance of Oasis Fertility, Kurnool. The centre conducted a mass baby shower to felicitate all mothers-to-be who conceived through IVF treatment. I Hospital Watch

Microbioz India, February 2023 | 33 Speaking on the occasion, Dr Vijaya Lakshmi D, Clinical Head and Fertility Specialist, Oasis Fertility, Kurnool stated, “I am very delighted to be part of this wonderful occasion, and my heartfelt wishes to all the mothers-to-be. At Oasis Fertility, we provide all kinds of advanced fertility treatments to both men and women enabling them to have their own biological children. Several million babies have been born out of IVF all over the world and hence couples need to come out of their fears and inhibitions and visit a fertility centre if they are unable to conceive even after a year. Couples should also be aware that fertility declines with age and therefore the earlier the intervention, the better the outcomes. The infertility problem is on the rise world over, due to lack of awareness only 1% of those seek treatment. Oasis through advanced technologies is in a position to make couples conceive their own genetic babies. We have fertility preservation facility in Kurnool, to help patients suffering from cancer, as radiation and chemo therapies such patients undergo, harms their healthy cells. These patients can now do testicular tissue freezing in case of men and oocyte freezing for women, very few centers have this facility. We are also offering Drug Free IVF called CAPA IVM for the first time in the country. Oasis has till date fulfilled the dreams of 67000 couples.” Chief Guest Smt. S.V. Vijayamma Garu, YSRCP Leader, said, earlier women had to bear the blame for not getting pregnant or conceiving a baby and the man went about marrying more women to bear his child. But infertility treatment brought about a change in the mindset and made men to realize that the cause for not bearing a child could be due to deficiency in them and that’s a happy development. But the belief of women being responsible for not conceiving, continues in rural areas, therefore there is utmost need to build awareness about infertility treatment in rural areas. To seek infertility treatment people had to go to far of places like Hyderabad and Bangalore, but such advanced treatment is available in Kurnool itself. I look forward to Oasis setting up centers in smaller towns in the neighborhood of Kurnool and reaching out to semi-urban and rural populace. Guests of Honour Smt. B.T. Jaya Lakshmi Garu, B.A.N.I.S Yoga Master & National Gold Medalist; said, earlier not bearing a child was considered to be a curse, but today infertility treatment can help couples conceive. Practicing Yoga can help bear healthy children and my advice to all the childbearing age couples is to adopt yoga for a better lifestyle. Dr. Vinusha Reddy Garu, Gold Medalist, State BJP Spokesperson; said, in our country there are more than 2.73 crores childless couples. Our culture giving children is given lot of importance, though not much prominence is given to this by Westerners. The childless couple endure enormous trauma, especially the women get blamed for it. Oasis is known to provide the latest treatment and is now offering India’s first CAPA IVM (Drug Free IVF) baby, thus the best possible infertility care in the country. Oasis is also known for its ethical care as trust is very critical in infertility care. Oasis center here is a boon for the people of Kurnool. Dr. Vijayalakshmi Dasari, Clinical Head & Fertility Specialist, Oasis Fertility; joined the couples who conceived through IVF, along with the kids at the Mass Baby Shower Celebrations, hosted by Oasis Fertility, at Oasis Fertility, Kurnool, today. ABOUT OASIS FERTILITY: Oasis Fertility, a unit of the Sadguru Healthcare Services Pvt. Ltd., has redefined reproductive care in India by bringing in internationally recognized best practices and protocols in Fertility treatments. It offers would-be parents a friendly ‘one-stop’ daycare clinic where consultations, investigations, and treatment are all conducted under one roof. Since its inception in 2009, Oasis has gained an excellent reputation for its high success rates driven by its high-quality services led by a team of experienced infertility specialists with international experience. The chain has expanded to 30 centres across the states of Andhra Pradesh, Telangana, Tamil Nadu, Karnataka, Jharkhand, Gujarat, Maharashtra, and Odisha. Apollo Medical College commemorates ‘World Congenital Heart Defect Awareness Day’ by performing the 150th Pediatric cardiac Procedure! pollo Institute of Medical Sciences & Research Hospital (AIMSR, Apollo Medical College) commemorated World Congenital Heart Defect Awareness Day - 14th February 2023; by reaching the spectacular milestone of 150 Pediatric cardiac procedures and surgeries performed for congenital heart defects in the last one year alone, at the Apollo Medical College, Hyderabad. A Hospital Watch

Microbioz India, February 2023 | 34 Congenital heart defect (CHD) is the most common type of birth defect, 1 out 100 infants are impacted by this. 25% of the CHDs require surgery or a procedure within the baby’s first year of life. More than 90% of the children with CHD, live into adulthood. The team of pediatric specialists at Apollo Medical College, involved in achieving this humongous landmark, Dr Sri Krishna, Head of Department of Pediatrics; Dr Amol Gupta, Pediatric Cardiologist; Dr Meena Trehan, Pediatric Anesthetist and Intensivist and Dr Sunil Kumar Swain, Paediatric Cardiothoracic & Vascular Surgeon; were felicitated on the occasion. The parent’s Mr. Kuruva Sri Ramulu & Mrs. Uma Devi of the 150th child Master Kuruva Manoj, a 2 years 8 months boy who had been discharged from the Pediatric ICU, from Arikera village, Kurnool district, Andhra Pradesh; were also felicitated on the occasion. This baby boy was suffering from a rare condition caused by a combination of four heart defects that are present at birth. Tetralogy of Fallot defects cause oxygenpoor blood to flow out of the heart and into the rest of the body. Risk factors include a viral illness such as rubella (German measles) during pregnancy, maternal alcoholism or a family history of the condition and was treated for the same by performing a critical ICR - Complete Repair of Tetralogy of Fallot, he had recovered well and was discharged. Apollo Medical College marked the World Congenital Heart Defect Awareness Day by hosting a Congenital Awareness Walk, early in the morning, to raise awareness about congenital heart problems and the need to detect early, for the child to lead a normal life. The College conducted a Continuous Medical Education program to build awareness in the medical fraternity about congenital heart disease and the paramount importance of early detection. MEDLEYMED SMARTZ ERP offers end-toend solutions, bring about operational efficiencies & faster ROI for pharmacies! ndia’s largest digital platforms for pharmacy businesses and virtual patient care solutions; announced the launch of a Retail Pharmacy Software and Pharmacy Point of Sale System MedleyMed SmartZ ERP. The SmartZ ERP renders end-to-end solutions for pharmacies thereby brings about operational efficiencies of pharmacies, be it single stores or pharmacy chains. The ERP solution enables faster ROI for the entrepreneurs. The cloud-based digital solution, MedleyMed SmartZ simplifies the management of pharmacy business and empowers to perform secure operations. I Hospital Watch

Microbioz India, February 2023 | 35 The 360-degree services offered by the platform encompasses Inventory management, Customer management including Billing, Expiry management, Invoice management, Product pricing, Vendor management and Financial Reporting among others. To enhance easy access to customers, a dedicated e-commerce-based website for the Pharmacy Store is part of the ERP plan. SmartZ ERP is a comprehensive solution for pharmacies to maintain and manage in-store and online inventory from a single platform. It gives a gateway to the web storefront to display products online and take online customer orders as well. All the products from the pharmacy are displayed online for customers with real-time inventory status. SmartZ ERP will help increase sales and cut costs of the pharmacy, thus giving the much-needed push in the competitive landscape. It will reduce the time required for performing in-store activities and will streamline supply chain functions like inventory and order management. It also comes with fully functional modules for accounting and working capital management and will result in greater cost savings and increased profitability for the business. SmartZ ERP provides a simple and efficient way to manage the expiry of the product in a pharmacy. It creates expiry reports and send notifications for expired products, so that the pharmacist enables timely returns to the suppliers. This will ensure that the pharmacy gets return value for all the expired items and do not suffer losses. SmartZ ERP runs smoothly on mobile and tablet devices, allowing the pharmacist to manage the shop from just about anywhere. This eliminates the need to visit the store to handle the business. All functions can be carried out while on the move. SmartZ ERP has inbuilt modules and features to enhance customer follow-up experience. The pharmacy can use email and SMS communication about customers’ upcoming medicine requirements based on their purchases. The pharmacy can enable reward points for customers too. The complete module strives to enable customer delight and a happy shopping experience. About MedleyMed Medley Medical Solutions Pvt Ltd is a Hyderabad based B2B and B2C healthcare player. It is considered as one of India’s largest digital platforms for pharmacy businesses and virtual patient care solutions. At MedleyMed, we believe that technology provides an important part of the solution. Leveraging a best-in-class application stack, we are making the healthcare value chain more efficient. Improving outcomes, lowering costs, and matching supply and demand ensures that healthcare works for everyone—for patients and providers. Our work is making the experience of buying medicines online better. Besides technology, we bring a collaborative approach to the table. All talk of creative destruction by startups aside, we believe that outcomes in the healthcare sector depend to a large degree on the expertise of providers. We have unconditional respect for this expertise and that is why we seek to work with existing players in a spirit of cooperation, rather than competition. Hospital Watch

Microbioz India, February 2023 | 36 We aspire to be a platform that brings together the different moving parts of the healthcare machine and ensures that they work together in harmony. Our technology expertise helps our partners reach new customers, improve service quality, and explore new revenue streams. We have a twin focus on ensuring better experiences for our customers and better growth for our partners. For more social media updates, follow us on: Insta: medleymedicalsolutions Facebook: medleymedicine LinkedIn: MedleyMed Oasis Fertility creates India’s first CAPA IVM baby asis Fertility creates history! India’s first CAPA IVM (Drug Free IVF) baby is born in Warangal. Dr Jalagam Kavya Rao, Clinical Head & Fertility Specialist, Oasis Fertility, Warangal has achieved this feat under the mentorship of Dr Durga G Rao, Co-founder & Medical Director, Oasis Fertility and Dr Krishna Chaitanya, Scientific Head and Clinical Embryologist, Oasis Fertility. CAPA IVM is the latest addition to traditional infertility treatment practices like IUI, IVF, ICSI, etc. This treatment is unique and is being offered by very few centres in the world. Oasis is the only centre in India to have expertise in CAPA IVM. Speaking on the occasion, Dr Jalagam Kavya Rao, Clinical Head & Fertility Specialist, Oasis Fertility, Warangal, stated, “We are extremely delighted to create the first CAPA IVM baby in India. CAPA IVM or Drug Free IVF is a groundbreaking technique and it is a boon to women with PCOS, Thrombophilia, Resistant ovary syndrome, Oocyte maturation problems, and women who have Cancer and need immediate treatment. We need everyone to understand that there are exclusive treatment options for every infertility issue and IVF is not the only treatment. CAPA IVM is less intensive, less invasive, and more economical. It’s high time people come out of their inhibitions, and fears and embrace parenthood through assisted reproduction technology if they are unable to conceive”. Mr. Sudhaker Jadhav, Chief Operating Officer, Oasis Fertility, stated, “It’s been a great pleasure to be part of this memorable chapter in the books of Oasis Fertility. Our continuous efforts in providing affordable, accessible, patient-friendly, and safe fertility treatments have led us to be the architects of India’s first CAPA IVM baby. We are a techdriven organization and are always at the forefront to adopt advanced technology and practices that would help us in improvising our services to the couples. This massive achievement that too the first of its kind in India is a testimony to our unwavering commitment toward providing quality treatment, passion for research, and above all the stunning efforts, dedication, and hard work put in by our clinicians and embryologists”. ABOUT OASIS FERTILITY: Oasis Fertility, a unit of the Sadguru Healthcare Services Pvt. Ltd., has redefined reproductive care in India by bringing in internationally recognized best practices and protocols in Fertility treatments. It offers would-be parents a friendly ‘one-stop’ daycare clinic where consultations, investigations, and treatment are all conducted under one roof. Since its inception in 2009, Oasis has gained an excellent reputation for its high success rates driven by its high-quality services led by a team of experienced infertility specialists with international experience. The chain has expanded to 30 centres across the states of Andhra Pradesh, Telangana, Tamil Nadu, Karnataka, Jharkhand, Gujarat, Maharashtra, and Odisha. Bengaluru, Karnataka, India Garuda Aerospace, a leading provider of drone technology solutions, today announced a partnership with Narayana Health, one of India's leading healthcare providers, for transporting bio medical samples using drones called ‘Sanjeevani’, the name as suggested by Dr Devi Shetty, O Hospital Watch

Microbioz India, February 2023 | 37 Chairman & Executive Director, Narayana Health. The partnership aims to revolutionize the delivery of critical and emergency medical supplies-including samples for diagnosis in times of high traffic and other challenging conditions. Garuda Aerospace and Narayana Health join hands to transport biomedical samples using Sanjeevani drones he use of drones in the healthcare industry has proven to be a game changer, saving valuable time and improving patient outcomes. The technology and expertise of Garuda Aerospace in the health sector have been leveraged in recent times, and with this Narayana Health will be able to transport bio medical samples quickly ensuring that patients receive timely diagnoses and treatments. This will also ensure to help the ones in remote and underserved areas too. During the pandemic, Garuda Aerospace used its emergency drones to deliver medicine and vaccinations to hospitals in partnership with Swiggy. The company's White Knight drones delivered essential medicines and vaccinations to Bengaluru hospitals for ISRO in 2021, demonstrating their capability in providing timely and efficient medical delivery. Speaking on the partnership, Agnishwar Jayaprakash, Founder and CEO, Garuda Aerospace said, "We are delighted to partner with Narayana Health and bring innovation to India's healthcare sector by using Garuda Aerospace drones. Our aim is to improve access to critical medical supplies and support the delivery of high-quality healthcare to patients in need and in times of emergency. With this partnership, we are confident that we will be able to make a real difference in the lives of patients and communities across India. We are proud to be a part of this exciting journey.” Dr Devi Shetty, Chairman & Executive Director, Narayana Health, said, "We are committed to delivering the best possible care to our patients. The use of drones to transport bio medical samples is a critical step in achieving that goal. By partnering with Garuda Aerospace, we are able to leverage their expertise to improve the delivery of medical supplies and enhance the quality of care we provide across. In the first phase, drones will be deployed in Bengaluru to transfer bio medical samples from Narayana Health City and HSR Layout on a daily basis. In the next 1 year, our network of 21 hospitals will have these services." Honorable PM Narendra Modi Ji simultaneously flagged 100 Kisan drones in 100 villages across India with live tracking, data collection, and processing. Garuda Aerospace has been the preferred drone partner for NDRF since the pandemic. Equipped with 400 drones and over 500 pilots across 84 cities, Garuda Aerospace is equipped to support different emergencies. Former captain of India's national cricket team Mahendra Singh Dhoni unveiled a camera drone called Droni at The Global Drone Expo in Chennai and became the firm’s Brand Ambassador as well. T Hospital Watch

Microbioz India, February 2023 | 38 About Garuda Aerospace Garuda Aerospace is India’s leading Drone tech startup focused on disrupting two major multibillion-dollar sectors, Precision Agri Tech and Industry 4.0 upgradation. Garuda Aerospace is asset-light, recession-proof, agnostic, and focuses on eliminating labours in the agricultural field with drones focusing on the design, building, and customization of Unmanned Aerial Vehicles (UAVs). Founded in 2015 with a team of 5, Garuda has scaled to 200+ member team having the largest drone fleet in India with over 400 drones and 500 pilots operating in 84 cities. Garuda Aerospace manufactures 30 types of drones and offers 50 types of services. Having served over 750 clients including TATA, Godrej, Adani, Reliance, Swiggy, Flipkart, Delhivery, L&T, Survey of India, SAIL, NTPC, IOCL, Smart cities, Intel, Amazon, Wipro, IISC, MIT Boston, NHAI for various projects, the company recently partnered with global giants such as Lockheed Martin, Cognizant and Elbit Systems. Garuda Aerospace is the first drone company to get DGCA approvals for Type Certification and Remote Pilot Training Organisation. Garuda is on a mission to impact 1 billion lives positively using affordable precision Drone Technology. Mahendra Singh Dhoni has invested in the company and is the Brand Ambassador. For details, visit www.garudaaerospace.com. About Narayana Health With all super-speciality tertiary care facilities that the medical world offers, Narayana Health is a one-stop healthcare destination for all. Founded by Dr. Devi Shetty and headquartered in Bengaluru, Narayana Health group is the second largest health care provider in the country in terms of operational bed count. The first facility was established with approximately 225 operational beds in year 2000 at NH Health City in Bengaluru. The Company today operates a chain of multispecialty tertiary and primary healthcare facilities across a network of 21 hospitals and 4 heart centres in India and single hospital overseas at Cayman Islands with nearly 6145 operational beds across all its centres and potential to reach a capacity of over 6,490 beds. Shree Mahavir Jain Hospital receives commendation from Thane Central Jail hree Mahavir Jain Hospital is proud to announce that it has received a commendation from Thane Central Jail for its exceptional medical healthcare services, in the form of camps every month. The Chief Operating Officer, Mr. Ajit J. Shah was presented with a letter of appreciation by Harshad Ahirrao, Superintendent, of Thane Central Prison on January 26th, 2023. Shree Mahavir Jain Hospital has been providing Medical Healthcare camps for General Health check-ups for Physical Fitness, Dermatology (Skin Infections) applications, Ear-Nose-Throat (ENT) OPDs, Opthal check-ups with assessmentsdiagnoses-treatments & co-operations by doctors & healthcare professionals at Thane Central Jail every month since November 2022. The inmates have been receiving the best medical attention and care, which has been acknowledged by the Jail authorities. All the camps were performed not just with medical assessments & line of treatments but also every patient was provided with pharmacy supplies as well when prescribed. The Thane Central Jail authorities have expressed their appreciation, gratitude & satisfaction with the services provided by Consultants, Technicians, Nurses, Medical officers, Healthcare staff, Hospital Management, and the Trust Board of Shree Mahavir Jain Hospital. S Hospital Watch

Microbioz India, February 2023 | 39 Mr. Ajit Shah, while receiving the letter of appreciation, expressed his regards & gratitude towards the Thane Central Jail authorities. He also mentioned that Shree Mahavir Jain Hospital is committed to making quality healthcare available to all and is proud to have been associated with the Thane Central Jail. Shri Mahendra Jain, Managing trustee, Shree Mahavir Jain Hospital informed that the trust is committed to serving humanity at all possible levels and will continue to conduct monthly check-up camps at Thane Central Jail. About Shree Mahavir Jain Hospital: Shree Mahavir Jain Hospital (SMJH) is a joint initiative of the Thane Municipal Corporation and JITO Educational and Medical Trust. SMJH was founded in 2019 at Thane and regarded as one of the best multispecialty hospital in Thane. It offers a varied spectrum of medical healthcare services. Shree Mahavir Jain Hospital Thane thrives to make quality healthcare affordable and accessible to everybody at nominal cost. Visit: http://mahavirjainhospital.com India has a long way to reach Zero Catastrophic Costs goal for TB patients: suggests study by The George Institute for Global Health, India Researchers recommend higher awareness of TB in the community, reduction of delays in diagnosis and treatment initiation to reduce the economic burden on patients and their families ecent study led by Dr. Susmita Chatterjee from The George Institute of Global Health, India, has shed light on the longterm economic impact of TB on patients, even a year after the end of treatment. The study has also shown that India still has a long way to go to reach the goal of zero catastrophic costs for all patient groups, as stated in the END TB Strategy. As an outcome of the understanding, the scientists have recommended a few strategic solutions to reduce the catastrophic impacts of TB in India. Reducing delays in diagnosis and treatment initiation (patients visit on average 12 healthcare providers before getting diagnosed with TB) can reduce the costs associated with TB treatment, its aftermath, and its related economic consequences. Creating awareness about the symptoms of TB in the community and availability of free diagnostic and treatment facilities in the government sector is crucial in this regard, they say. They also recommend that policy changes must ensure that the livelihood of TB patients is not disrupted and hence, the changes should include the provision of job security, additional food support, better management of direct benefit transfers, and improved medical insurance coverage. Other than The George Institute for Global Health, India, researchers from Indira Gandhi Government Medical College in India, the University of New South Wales (Australia), and the London School of Hygiene and Tropical Medicine (UK) also participated in this study. The study that underscores the importance of understanding the economic impact of TB on patients and their households has been published in PLOS Global Public Health, in a paper co-authored by Dr. Susmita Chatterjee, Senior Health Economist – The George Institute, India, Palash Das, Research Fellow – The George Institute India, Aaron Shikhule – University of New South Wales Australia, Radha Munje - Indira Gandhi Government Medical College, and Anna Vassal - London School of Hygiene and Tropical Medicine (UK). Highlighting the importance of the study, Dr. Susmita Chatterjee, Senior Health Economist – The George Institute, India said, “India bears the highest burden of TB in the world, with 26.4 lakh cases reported in 2019 alone. Not only does the disease impact the health of individuals, but it also has significant economic consequences and we quantified those consequences to take R protective action.” Hospital Watch

Microbioz India, February 2023 | 40 The study, conducted between 2019 and 2021, examined the experiences of 829 adult patients who had TB that is responsive to medication (drugsusceptible TB). Study participants were from general population and from two groups who are at high risk of having TB because of their poor living conditions and nutrition: people living in urban slum areas and tea garden areas. Each participant was interviewed three times: once at the beginning of treatment (0-2 months) then during the continuation phase of treatment (5-6 months) when they were almost finishing their treatment, and finally post-treatment i.e., 8-12 months after treatment was completed. Elaborating on the details of the survey, Dr. Susmita Chatterjee said, “The collected data covered socio-economic conditions, employment status, patient and household income, out-of-pocket expenses, and time spent on outpatient visits, hospitalization related to TB, TB drug pick-up, medical follow-ups after initiation of TB treatment, expenses on additional food during TB treatment, and coping strategies such as dissaving, borrowing, and selling assets.” The observations were disturbing as the total cost of TB treatment from the onset of symptoms to one-year post-treatment ranged from Rs. 26,500 – 30,500 per patient despite free diagnosis and treatment provided by the government. Of this, 32% to 44% of costs were incurred in the pretreatment phase (i.e., from the initiation of TB symptom till initiation of treatment), while 6%-7% were incurred in the post-treatment phase. The unemployment rate was seen to increase from pretreatment (before TB) to the intensive phase (i.e., at the beginning of TB treatment), but decreased during the continuation phase (i.e., at the end of TB treatment), although it remained above the baseline even after about one year of treatment completion. The low income of the patients along with high unemployment because of TB forced them to borrow money and/or sell / mortgage their personal belongings during treatment which resulted in a high outstanding loan in the posttreatment phase. Further, to manage the outstanding loan, they had to borrow/sell/mortgage during the post-treatment period as well. Apart from that, there were other economic consequences that included reduced food consumption for family members as they ensured proper food for patients; inability to pay regular bills such as electricity, mobile, cable etc; buying regular groceries on credit; not being able to attend events like weddings or other social functions as they did not have money to buy gifts or for travel both during treatment and post-treatment period. This clearly emphasized that the economic impact of TB does not end with the completion of the TB treatment: it continues long after. “Interestingly, our study indicated that financial insecurity affects patients across all categories,” said Dr. Susmita Chatterjee. Amara Hospital launches Sleep Outreach Clinic in Hyderabad for City’s Working Professionals mara Hospital, a leading healthcare service provider, today launched their Sleep Outreach Clinic located on the premises of the Amara Raja Corporate Office in the Financial District, in order to serve the working population in this area, especially IT workers. The clinic was inaugurated today by Dr. Ramadevi Gourineni, in the presence of renowned actor, Murali Mohan Garu, and Film Director, Raghavendra Rao Garu. A Hospital Watch

Microbioz India, February 2023 | 41 Due to lifestyle changes such as sedentary lifestyle, increased work times, shift work, greater screen time and increased use of alcohol, cigarettes and caffeine, we are seeing a dramatic rise in sleep issues especially among IT professionals. Sleep is vital for health and plays an important role in growth, repair and immunity. Sleep is also required for memory consolidation, emotional regulation, and appetite control. It is therefore not surprising that chronic sleep loss and disturbed sleep may lead to weight gain, irritability, memory problems, reduced work performance and impaired social relationships. Sleep problems include difficulty in sleeping at night, daytime sleepiness, snoring, pain and movements at night that affect sleep. People may also walk, talk, scream and engage in complex movements at night. People who snore may have obstructive sleep apnea (sleep disorder characterized by episodes of not breathing at night associated with a fall in oxygen saturation of the blood), which can be associated with hypertension, daytime sleepiness, heart disease and accidents at work and on the road due to daytime sleepiness. Studies also show that sleep apnea is associated with a five-time increase in all-cause mortality. On the occasion of the inauguration of the sleep centre, Dr Ramadevi Gourineni said, "As part of our treatment protocol, we will focus on suggesting lifestyle changes, rather than opting for medications for any sleep related issues. We have developed a comprehensive lifestyle plan which will aid in treating the disorders in a more balanced way. The clinic is equipped to evaluate and treat all categories of sleep disorders in a holistic manner and we are conveniently located in the IT hub, making it easy for people to access us." Dr. Ramadevi Gourineni is the Managing Director of AMARA Hospital and an American BoardCertified Sleep Specialist who worked as an Associated Professor of Neurology at Northwestern University, prior to returning to India. She has over 20 years of experience in the US in treating sleep-related health issues. About Amara Hospital: Amara Hospital Tirupati is a multi-specialty, onestop solution for patient’s healthcare needs. The hospital focuses on both Primary and Specialty care with international standards at affordable prices. Amara hospital is run by Dr. Varaprasad and Dr. Ramadevi Gourineni who are an NRI doctor couple who share a great passion for patient care and teaching. They returned to India with a commitment to provide service to their hometown and to provide learning/employment opportunities for young professionals in Rayalaseema. Hospital Watch

Microbioz India, February 2023 | 42 QIAGEN Launches Automated Sample Processing Platform for Diagnostic Labs Story source/Credit: QIAGEN IAGEN launched EZ2 Connect MDx for use in diagnostic laboratories, an IVD platform for automated sample processing that is now available for widescale use after being made available for research. The EZ2 Connect MDx aims to enable labs to purify DNA and RNA from 24 samples in parallel in as little as 30 minutes1 . The device carries the EU’s CE-IVD compliance marking for in vitro devices (IVD) for the European Union and other countries that accept this designation. It is also available in the United States, Canada, and other countries. “EZ2 Connect MDx puts standardized and efficient nucleic acid purification in reach of any clinical lab,” says Jean-Pascal Viola, senior vice president, head of the Molecular Diagnostics Business Area at QIAGEN. “It solves the challenges of many clinical diagnostics labs that have to provide diagnostics results quickly, that have to deal with fluctuating sample numbers as well as a large variety of sample types and quality.” EZ2 Connect MDx can extract nucleic acids from blood plasma, serum, stool, and other sample types using magnetic-bead technology. High process safety is ensured with prefilled and sealed reagent cartridges, as well as load checking through integrated cameras. Other features include UV decontamination, onboard pipetting and heating as well as automated piercing of the sealed cartridge. The resulting analyte is compatible with a variety of downstream technologies such as real-time PCR, digital PCR, and next-generation sequencing. The device is also designed to handle a wide range of sample material thanks to QIAGEN’s kit portfolio and customizable protocols. It can be used in research mode with research kits (MBA) or in dedicated IVD mode with EZ1 DSP kits as well as protocols for diagnostic workflows. Another key feature is the ability to use the QIAsphere digital laboratory ecosystem, which enables full integration into the digital infrastructure of a lab that allows for remote instrument management. References: 1 Protocol run time varies depending on the number of samples processed and the protocol selected. Q Product Launches

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Microbioz India, February 2023 | 44 Thermo Fisher Scientific launches real-time PCR kits for detection of infectious diseases in India Story source/Credit: Thermo Fisher Scientific esigned to deliver confidence and reliability for diagnostic development and testing, the Applied Biosystems™ TaqPath™ PCR kits for infectious diseases such as Multi-Drug Resistant Tuberculosis (MTB MDR), M. Tuberculosis complex (MTB), Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Human Immunodeficiency Virus (HIV), and for genetic analysis (HLA B27), have received licensing rights by the Central Drugs Standard Control Organisation (CDSCO) and will be manufactured in India in association with Mylab Discovery Solutions, India’s leading healthcare company. The Applied Biosystems™ TaqPath™ PCR kits have been analytically- and clinically-validated for use in patient care for disease screening and diagnosis, monitoring of therapeutic response and disease progression, and identification of genetic risk factors. Thermo Fisher Scientific offers a complete qPCR ecosystem, which includes the Applied Biosystems QuantStudio 5 Dx Real-Time PCR System and upcoming QuantStudio 7 Pro Dx Real-Time PCR Systems designed to simplify workflows, a broad portfolio of master mixes and PCR plastics, RNA/DNA for sample preparation and biosafety cabinets, centrifuges, cold storage, pipettes and tips to support the entire end-to-end workflow of any diagnostic lab. “Over the years, India has made significant progress in addressing infectious diseases such as Hepatitis B and C, HIV, and Tuberculosis. The country has implemented large-scale vaccination and treatment programs, as well as invested in research to better understand the epidemiology of these diseases and develop new diagnostic tools. However, India still faces challenges in controlling the spread of these diseases. At Thermo Fisher Scientific, we are committed to offering new innovations and workflows to advance research and diagnosis of these infections while actioning our mission, to enable our customers to make the world healthier, cleaner and safer”, said Jagjit Singh Anthak, Director, Genetic Sciences Group and Specialty Diagnostics Group, Thermo Fisher Scientific. D Product Launches

Microbioz India, February 2023 | 45 Key Application are Clinical laboratories, Molecular diagnostic development and testing, lot-to-lot reproducibility, Ct consistency, and wide linear dynamic range. * Feature are - High sensitivity to detect low-copy targets with reproducible Ct results Wide dynamic range compatible with multiplexing applications Tolerant of inhibitors commonly found in clinical samples Manufactured in an ISO-13485 facility to help ensure excellent manufacturing consistency Exceptional data quality- high specificity, dynamic range*, and reproducibility for genotyping and copy number determination Tolerance to inhibitors- compatible with samples prepared from human or animal sources (buccal swabs, blood, and card punches) Multiplexing breadth—detect up to 4 targets per reaction Excellent manufacturing quality— manufactured in an ISO 13485–certified facility *For Laboratory Use. It is the customer’s responsibility to ensure that the performance of the product is suitable for customers’ specific uses or applications. “We are proud to be associated with Thermo Fisher and develop world class molecular diagnostics kits,” said Hasmukh Rawal, Managing Director at Mylab Discovery Solutions. “Laboratories in India and globally rely on the innovative products from Thermo Fisher, will now also benefit with a much wider range of quality diagnostic tests. Also, we would be assisting in tools for analysis of data to help labs make accurate results to their customers. This is a milestone moment in Indian diagnostics.” About Thermo Fisher Scientific Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue of more than $40 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, increasing productivity in their laboratories, improving patient health through diagnostics or the development and manufacture of life-changing therapies, we are here to support them. Our global team delivers an unrivaled combination of innovative technologies, purchasing convenience and pharmaceutical services through our industryleading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services, Patheon and PPD. For more information, please visit www.thermofisher.com. AstraZeneca collaborates with Benchling to deliver industry-first DNA assembly tool Story source/Credit: Benchling Benchling – the cloud R&D powering the biotechnology industry – launches a new whitepaper in partnership with AstraZeneca, exploring how AstraZeneca has become the first company to recycle critical DNA constructs at scale, reducing the cost of creating DNA constructs by 80- 90%. he whitepaper explores how AstraZeneca’s combined team of computational and molecular biologists, along with Benchling, have created the FRAGLER (FRAGment recycLER), a novel solution for the whole DNA synthesis industry, and one that is opensourced, available now on GitHub. DNA constructs are vital to kick-start drug development, but the time and cost of producing them can significantly delay or even halt treatments getting to market – something that became particularly evident during the COVID-19 pandemic. T Product Launches

Microbioz India, February 2023 | 46 For biotech’s to be able to innovate and drive scientific discoveries, they need the ability develop DNA sequences with flexibility and at scale – and this is what AstraZeneca and Benchling have addressed. By integrating FRAGLER into Benchling, AstraZeneca has been able to accelerate its approach to deliver an industry-leading automated lab ecosystem. Through increased efficiency, it’s possible for DNA construction to take just 3 weeks, compared to 4-8 weeks typically, and deliver cost savings from 50 to 90%. Bio-Rad’s CFX Opus Deepwell Dx Real-Time PCR System Advances Large Reaction Volume IVD Assay Development and Diagnostic Testing Story source/Credit: Bio-Rad Laboratories, Inc. CFX Opus Dx Real-Time PCR Detection Systems for In Vitro Diagnostics (IVD) io-Rad Laboratories, Inc., a global leader in life science research and clinical diagnostic products, has announced the launch of the CFX Opus Deepwell Dx Real-Time PCR System, a real-time PCR system listed with the U.S. Food and Drug Administration (FDA) for in vitro diagnostic (IVD) testing, and developed in accordance with the European Union’s regulations for in vitro diagnostic medical devices (EU 2017/746). Bio-Rad will continue to seek regulatory approvals for additional global markets in the coming months. The CFX Opus Deepwell Dx Real-Time PCR System is the latest addition to the Bio-Rad portfolio of real-time PCR instruments. The system offers accurate and precise quantification with flexibility for reactions up to 125 µl in a 96-well format for quantitative PCR (qPCR) diagnostic assays. The CFX Opus Dx Real-Time PCR System is also available in a 96- and 384-well reaction block format. All systems in the CFX Opus Dx Real-Time PCR family are open platforms that can multiplex up to five targets to enable efficient IVD assay development and diagnostic testing. CFX Opus Dx Real-Time PCR Systems offer easyto-use desktop management and analysis software with integrated security features for electronic signature, audit, and user control. "With the ongoing increase in demand for efficient and flexible IVD real-time PCR systems, we are pleased to announce the addition of the CFX Opus Deepwell Dx Real-Time PCR System to the CFX Opus family,” said Steven Blakely, Senior Director for the Gene Expression Business, Bio-Rad. “The CFX Opus Deepwell Dx Real-Time PCR System continues in the tradition of robust and secure platforms that leverage the long-standing Bio-Rad expertise in genomic tools to serve both research and clinical diagnostic markets,” he added. BIO-RAD is a trademark of Bio-Rad Laboratories, Inc. About Bio-Rad Bio-Rad Laboratories, Inc. (NYSE: BIO and BIOb) is a global leader in developing, manufacturing, and marketing a broad range of innovative products for the life science research and clinical diagnostic markets. With 70 years of focus on quality and customer service, our products advance the discovery process and improve healthcare. Our customers are universities, research institutions, hospitals, public health and commercial laboratories, and biotechnology and pharmaceutical companies, as well as applied research laboratories including food safety and environmental quality. Based in Hercules, California, Bio-Rad has a global network of operations with approximately 8,200 employees worldwide and $2.9 billion in revenues in 2021. B Product Launches

Microbioz India, February 2023 | 47 bit.bio chooses Automata as partner for automating a key aspect of its production of iPSC derived human cells Story source/Credit: Automata Automation will support bit.bio’s production of its scalable, consistent human cells for research and drug discovery with greater manufacturing capacity and speed than ever utomata, a leading robotics and automation company powering life sciences labs, has announced it is partnering with bit.bio, to automate a key aspect of the manufacturing process of their iPSC (induced pluripotent stem cell)- derived human cell products. bit.bio’s precision cellular reprogramming technology opti-ox is ideally suited for automation because it enables unprecedented consistency and scalability for the manufacture of human cells from iPSCs. The solution makes use of Automata’s leading expertise in lab automation at scale. It is custom designed for a crucial step in bit.bio’s production of its precision reprogrammed human cells and will streamline this step through automation, turning it into a consistent, standardised process. It will free up scientists’ time, reduce human errors and increase batch to batch reliability. This first step in automation will increase bit.bio’s capacity to manufacture human cell products for research and drug discovery by quadrupling manufacturing output and supports bit.bio’s lean manufacturing approach. It will increase the speed at which bit.bio can deliver products to market and support its rapidly expanding portfolio of human cells and disease models. Once validated, the aim is to expand automation to the GMP-grade production of cell therapy products. Together with this partnership bit.bio and Automata are moving further towards the fully automated lab of the future. Dr Mark Kotter, Founder and CEO, bit.bio comments: “As we continue to expand as a company, we are always looking for ways to streamline our processes. This year is our most ambitious yet and we are launching multiple new cell types and disease models so it’s essential we increase our manufacturing capacity. Being a fastgrowing company means we are able to work quickly and effectively with other fast-growing companies on novel solutions. We are excited to be partnering with Automata and will continue to look for novel ways to automate our workflows and build towards a lab of the future.” Mostafa ElSayed, CEO and Co-Founder, Automata adds: “We’re extremely proud to be partnering with pioneers bit.bio to demonstrate how our technology can help them in their development of consistent and scalable human cells. With automation, scientists will work smarter by running more processes with greater adaptability and higher quality data, and focus on the next great advances in human health.” About bit.bio bit.bio combines the concepts of coding and biology to provide human cells for research, drug discovery and cell therapy, enabling a new generation of medicines. This is possible with our precision cellular reprogramming technology, opti-ox™ - a breakthrough gene engineering approach that enables unlimited batches of any human cell to be manufactured consistently at scale through direct reprogramming of stem cells. The company was founded in 2016 by Dr Mark Kotter from his labs at the University of Cambridge after his discovery of the opti-ox technology. It has raised over $150m in funding so far, has over 180 employees and is headquartered in Cambridge, UK and San Francisco, US. About Automata Automata is the leading robotics and automation company powering the laboratories of the future. Our automated technology enables new and improved processes, empowers scientists with transformed ways of working and delivers faster translation of results from ‘bench to bedside’. Our Lab Automation Platform meets labs where they are on their automation journey, and we are the trusted partner to improving efficiencies and freeing scientists to work on new and innovative discoveries.   A Product Launches

Microbioz India, February 2023 | 48 We are trusted by customers including trusts within the NHS, and are supporting advancements across Core Testing Labs, Academic Institutes, CDMOs, Pharmas and Biotechs. Agilent and Akoya Biosciences Announce Partnership to Drive Multiplex Tissue Assay Development for Biopharma Applications Story source/Credit: Agilent Technologies gilent Technologies, Inc. has announced a partnership with Akoya Biosciences, Inc., The Spatial Biology Company®, to develop multiplex-immunohistochemistry diagnostic solutions for tissue analysis and to commercialize workflow solutions for multiplex assays in the clinical research market. Integrating Agilent’s Dako Omnis (autostaining instrument) and Akoya’s PhenoImager® HT (imaging platform) for multiplex chromogenic immunohistochemistry (mIHC) and immunofluorescent (mIF) assays will create a singular end-to-end commercial workflow, including reagents, staining, imaging, and analysis. Agilent and Akoya will partner to develop chromogenic and immunofluorescent multiplex assays that include spatial analysis for biopharma companies developing precision cancer therapeutics. These assay solutions will enable researchers and medical professionals to address patient selection needs of novel therapeutics and rapidly translate their discoveries into clinical testing. Spatial phenotyping using multiplex imaging provides the advantages of single-cell analysis while preserving spatial relationships between the cells. This offers an invaluable tool for uncovering novel insights into cellular organization in the tumor microenvironment and therapeutic response. This agreement will deliver an end-to-end multiplex solution for biomarker clinical research enabled by digital pathology, providing capabilities across the pharma value chain. Combining Agilent’s companion diagnostic and IHC workflow expertise, the large install base of Dako Omnis instruments, and a strong network of pharma partners; with Akoya’s install base of imagers, spatial analysis expertise, and CLIA lab capabilities will further empower biopharma partners to leverage this integrated workflow solution for their biomarker discovery and validation needs, helping drive better patient stratification. Under a separate Value-Added Reseller agreement, Akoya Biosciences will distribute and resell Dako Omnis as a part of the end-to-end multiplex solution. “We are delighted to be partnering with Akoya to create industry-leading products and services for multiplex chromogenic and immunofluorescence tissue assays,” said Sam Raha, president of Agilent’s Diagnostic and Genomics Group. “This partnership enables an ecosystem that assists the development of novel precision cancer therapeutics and offers a streamlined workflow to our joint customers in the clinical research market to meet the needs of future clinical diagnostics,” Raha added. “Multiplex tissue analysis has the potential to transform the field of cancer therapeutics and usher in a new era of precision pathology,” said Brian McKelligon, CEO of Akoya Biosciences. “This partnership and the combined strength of both organizations will catalyze the development and deployment of multiplex tissue-based biomarkers for the benefit of our biopharma and CRO partners and, ultimately, patients.“ About Akoya Biosciences As The Spatial Biology Company®, Akoya Biosciences’ mission is to bring context to the world of biology and human health through the power of spatial phenotyping. The company offers comprehensive single-cell imaging solutions that allow researchers to phenotype cells with spatial context and visualize how they organize and interact to influence disease progression and response to therapy. Akoya offers a full continuum of spatial phenotyping solutions to serve the diverse needs of researchers across discovery, translational and clinical research: PhenoCode™ Panels and PhenoCycler®, PhenoImager® Fusion, and PhenoImager HT Instruments. A Product Launches

Microbioz India, February 2023 | 49 About Agilent Technologies Agilent Technologies Inc. (NYSE: A) is a global leader in the life sciences, diagnostics, and applied chemical markets, delivering insight and innovation that advance the quality of life. Agilent’s full range of solutions includes instruments, software, services, and expertise that provide trusted answers to our customers' most challenging questions. The company generated revenue of $6.85 billion in fiscal 2022 and employs 18,000 people worldwide. Thermo Fisher Scientific Launches CE-IVD Marked Assay to Detect TreatmentResistant Strains of HIV-1 Story source/Credit: Thermo Fisher Scientific HIV-1 Drug Resistance Testing for Monitoring and Surveillance hermo Fisher Scientific, the world leader in serving science, has announced the launch of its CE-IVD marked Applied Biosystems TaqPath Seq HIV-1 Genotyping Kit, a Sanger sequencing-based assay that examines positive samples of human immunodeficiency virus (HIV) to identify genetic variants that may resist common antiretroviral therapeutics. Data derived from the test can help to serve as a critical tool to monitor and help treat HIV-1- infected individuals, as well as inform epidemiologic and genetic surveillance studies to track the ongoing evolution of the virus. Using HIV RNA extracted from plasma or dried blood spots, the assay is designed to analyze genomic mutations in the protease, reverse transcriptase and integrase regions of the HIV-1 pol gene across nine subtypes of global significance. Antiretroviral drug resistance testing is needed since greater than 10% of treatment-naïve adults, and about half of newly diagnosed infants, show resistance to first-line drug classes. Resistance is also emerging to the newer class of integrase inhibitorbased drugs, risking diminished effectiveness of these life-saving therapies.1 The enhanced assay design helps provide global clinical and public health laboratories with a standardized, costeffective tool to help manage the overall progression of HIV care and research, as well as public health strategies in support of the UNAIDS 2030 Fast Track targets. “Resistance to antiretroviral therapy is an important concern when providing care to people living with HIV,” said Dr. Manoj Gandhi, senior medical director of genetic testing solutions at Thermo Fisher Scientific. “This assay, along with its ability to use either plasma or dried blood spots specimen, fulfills an unmet clinical need that can help better manage people living with HIV with the aim of having them receive more effective therapies.” Equitable pricing is available to eligible customers through Thermo Fisher’s Global Health Equity program. 1 HIV drug resistance report 2021. Geneva: World Health Organization; 2021. License: CC BY-NC-SA 3.0 IGO About Thermo Fisher Scientific Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue of approximately $40 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, increasing productivity in their laboratories, improving patient health through diagnostics or the development and manufacture of life-changing therapies, we are here to support them. Our global team delivers an unrivaled combination of innovative technologies, purchasing convenience and pharmaceutical services through our industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services, Patheon and PPD. T Product Launches

Microbioz India, February 2023 | 50 Instrument-free, intuitive and for instant use: the Asteria™ scRNA-seq benchtop kit. Story source/Credit: Thistle Scientific Asteria™, the latest breakthrough singlecell RNA-sequencing kit developed by Scipio bioscience, is now commercially available for any researcher worldwide. his innovative hydrogel-based benchtop kit enables the transcriptomic profiling of 10,000 individual cells per sample, instrument-free. By purchasing the kit, researchers also gain access to its intuitive and entirely cloudbased analysis software, Cytonaut™. The combination of the kit and software is a comprehensive end-to-end single-cell solution – sequencing excepted – accessible to any scientist with or without prior knowledge of single-cell technology and bioinformatics. The new kit offers an opportunity for both singlecell researchers looking for an inventive alternative to the solutions offered by the current market and for scientists new to the field wanting to generate their first single-cell datasets without a heavy initial investment. At an affordable price, a researcher can process fresh samples of 10,000 cells immediately with a stable stopping point within two hours, simplifying sample management at the laboratory and limiting transcriptional changes. The straightforward hydrogel technology bypasses the use of microfluidics and nano-wells, allowing the generation of barcoded cDNA entirely on the workbench and independently from the studied cell types. For use with Asteria™, Scipio bioscience developed Cytonaut™, an end-to-end software solution covering pre- and post-processing analysis as well as interactive data visualization and generation of publication-ready results and figures. Hosted in a secure cloud infrastructure, it guides the user through the analysis step by step, enables researchers to free themselves from heavy computing resources and let them exploit their data without prerequired knowledge in bioinformatics. “We are achieving our goal of bringing a single-cell solution to every lab”, says Pierre Walrafen, CEO at Scipio bioscience, “empowering researchers to use single-cell sequencing unhindered by the technical, logistical and cost limitations of current solutions. With the Asteria™ kit ready in the freezer for onthe-spot profiling and cloud-based Cytonaut™ accessible from any computer for immediate bioinformatic analysis, anyone can start generating high-quality single-cell data on their own terms.” “When investigating the impact of radiotherapy on lung tissue, it is essential that we analyse our samples immediately to measure a transcriptomic profile as close to physiological conditions as possible”, comments Dr. Charles Fouillade from the Repair, Radiation and Innovative Anticancer Therapies team led by Prof. Arturo Londoño at Curie Institute, Paris, France. “And thanks to the Asteria™ kit protocol, we can quickly capture the mRNAs and resume the experiment the next day without loss of gene expression. The Asteria™ kit and Cytonaut™ software are extremely easy to use and will undoubtedly facilitate access to single-cell data for research teams throughout the world.” To distribute the Asteria™ single-cell RNA-seq kit, Scipio bioscience has partnered with Thistle Scientific in the UK and Ireland. T Product Launches