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Published by F. Lew, 2019-07-30 13:48:21

IV MASTER FORMULA MP2019.07.30

IV MASTER FORMULA MP2019.07.30

Med-Plus Pharmacy Inc. LAST UPDATE: 07/30/2019
SterileCompoundingMasterFormula

EQUIPMENT/SUPPLIES TO BE USED: Syringes, Alcohol Prep Pads, Needles, Pharmassist Pump, ISO Class 5 Hood (LAFWs), Exactamix (for TPN) INACTIVE INGREDIENTS: n/a
CLEAN ROOM GEAR TO BE USED: Bouffant Cap, Mask, Gown, Gloves, Shoe Cover ACTIVE DRUG IN LIQUID FORM:
STEPS IN PREPARING PRODUCT: ACTIVE DRUG IN POWDER FORM 1) Withdraw exact amount of active ingredient
1) Using ASEPTIC TECHNIQUE (w/ minimizing coring), reconstitute powder with STERILE WATER unless indicated otherwise. SHAKE WELL until completely dissolved 2) Add withdrawn amount and inject into prescribed solution listed in this table Inspect final product.
EXCEPT following drugs: CUBICIN®, COLISTIN®, RIFAMPIN®, TYGACIL® (Swirl the vial until the drug is dissolved) 3) Pharmacist to verify the accuracy of the drug, amount of active ingredient and solution
2) Inspect reconstituted solution visually to make sure the powder is completely dissolved. 4) Label bag
3) Add reconstituted solution into prescribed solution listed in table, again minimizing coring. **BUD (Beyond Use Date) Reference: ASHP's Handbook on Injectable Drugs, 18th edition & the United States Pharmacopeia (USP) Chapter <797>
4) Inspect final product. Pharmacist to verify the accuracy of the drug, amount of active ingredient and solution. 5) Label bag Pharmaceutical Compounding – Sterile Preparations, Title 16 CCR 1751 et seq.

RECONSTITUTION FINAL FLUID INFUSION STABILITY (BUD)**
(Withdrawl Vol) CONC. VOLUME RATE
DRUG STRENGTH FLUID LABEL Comments
ACYCLOVIR 10 mL 50 mg/mL Dose < 500mg: 100 mL 60 mins
(ZOVIRAX®) 500 mg 20 mL D5W ROOM TEMP. REFRIG.
1 Gm NS Dose >500mg: 250 mL 60 mins
AMIKACIN 1 Gm/20 mL _ 24 hrs _ Room Temp. *The reconstituted vial solution should be used within 12hrs.
500 mg/2mL (Max Conc: 7 mg/mL) *Refrigeration of reconstituted solution may result in the formation
AMPICILLIN 1 Gm/4mL _ of a precipitate which will redissolve at room temp.
500 mg
AMPICILLIN/SULBACTAM 1 Gm 5 mL 250 mg/mL D5W Dose ≤ 500 mg: 100 mL 60 mins 48 hrs 14 days Refrigerate *IV or IM
(UNASYN®) 2 Gm 10 mL 100 mg/mL NS 90 mins
20 mL Dose > 500 mg: 250 mL *Store the reconstituted vial @ REFRIG,
(Max Conc: 5 mg/ml) discard after 14days

30mg/mL: 24hrs in

Up to 30mg/mL: 8hrs N.S.

NS Only 100 mL 60 min. in N.S. Up to 20mg/mL: Refrigerate
(Max Conc: 30 mg/mL)
10-20mg/mL: 1hrin 48hrs in N.S.

D5W Up to 20mg/mL: 1hr

in D5W

*45 (30 AMP/15 *45 (30 AMP/15

1.5 Gm 3.2 mL (4 mL) SULB) mg/mL: 8 hrs SULB) mg/mL: 48 hrs

in N.S. in N.S.

375 mg/mL NS Only 100 mL 60 min. *30 (20 AMP/10 *30 (20 AMP/10 Refrigerate *IV or IM

SULB) mg/mL: 2hrs in SULB) mg/mL: 72 hrs

D5W in N.S.

3 Gm 6.4 mL (8 mL) *3 (2 AMP/1 SULB) *30 (20/10): 4 hrs in

mg/mL: 4hrs in D5W D5W

AMPHOTERICIN B 50 mg D5W Only 500 mL D5W for IV INF. 4-6 hrs *Not compatible w/ N.S
(FUNGIZONE®) (dose: should NOT FOR IV INF. (Max Conc: 0.1mg/ml) over 24 hrs *REFRIGERATE Unreconstituted Vial & PROTECT FROM LIGHT
exceed 1.5mg/kg/day) *Reconstituted solution kept in dark: 24hrs @ Room Temp, 7
10mL S.W. Only 5 mg/mL 24 hrs 7 days Refrigerate
days @ Refrig.
S.W. FOR
IRRIGATION 1L S.W. FOR IRRIGATION

50 mg 15 mL 50 mL 45 mins *REFRIGERATE unreconstituted vial.
100 mg 30 mL (infusion vol = 65 mL) 90 mins
ANIDULAFUNGIN (ERAXIS®) 3.33 mg/mL D5W 48 hrs 72 hrs Refrigerate *Reconstituted solution: 24hrs @ Room Temp.
NS 100 mL
(infusion vol = 130 mL) *Diluted solutions: stable for up to 48hrs @ Room Temp or

for 72hours if stored frozen. *IV ONLY

1

Med-Plus Pharmacy Inc. LAST UPDATE: 07/30/2019
SterileCompoundingMasterFormula

EQUIPMENT/SUPPLIES TO BE USED: Syringes, Alcohol Prep Pads, Needles, Pharmassist Pump, ISO Class 5 Hood (LAFWs), Exactamix (for TPN) INACTIVE INGREDIENTS: n/a
CLEAN ROOM GEAR TO BE USED: Bouffant Cap, Mask, Gown, Gloves, Shoe Cover ACTIVE DRUG IN LIQUID FORM:
STEPS IN PREPARING PRODUCT: ACTIVE DRUG IN POWDER FORM 1) Withdraw exact amount of active ingredient
1) Using ASEPTIC TECHNIQUE (w/ minimizing coring), reconstitute powder with STERILE WATER unless indicated otherwise. SHAKE WELL until completely dissolved 2) Add withdrawn amount and inject into prescribed solution listed in this table Inspect final product.
EXCEPT following drugs: CUBICIN®, COLISTIN®, RIFAMPIN®, TYGACIL® (Swirl the vial until the drug is dissolved) 3) Pharmacist to verify the accuracy of the drug, amount of active ingredient and solution
2) Inspect reconstituted solution visually to make sure the powder is completely dissolved. 4) Label bag
3) Add reconstituted solution into prescribed solution listed in table, again minimizing coring. **BUD (Beyond Use Date) Reference: ASHP's Handbook on Injectable Drugs, 18th edition & the United States Pharmacopeia (USP) Chapter <797>
4) Inspect final product. Pharmacist to verify the accuracy of the drug, amount of active ingredient and solution. 5) Label bag Pharmaceutical Compounding – Sterile Preparations, Title 16 CCR 1751 et seq.

RECONSTITUTION FINAL FLUID INFUSION STABILITY (BUD)**
(Withdrawl Vol) CONC. VOLUME RATE
DRUG STRENGTH FLUID LABEL Comments

ROOM TEMP. REFRIG.

500 mL D5W *Not compatible w/ N.S.
(final Conc: 1mg/ml) *FLUSH IV Line with D5W injection BEFORE & AFTER Infusion. If this
cannot be done, then a separate IV line must be used. Make/send
AMPHOTERICIN B LIPID 100 mg/ 20 mL _ 5 mg/mL D5W Only * For pediatric pt & pt w/ 3 hrs 6 hrs 48 hrs Refrigerate 10 mL DEXTROSE FLUSH SYRINGES for each dose (1 before/1 after
COMPLEX (ABELCET®) Suspension cardiovascular disease, the
final concentration may be 2 dose)
(3-5mg/kg/dose IV *Refrigerate Unreconstituted Vial & PROTECT FROM LIGHT
Q24hrs) mg/ml.
Filtration and Dilution:

• Prepare the admixture for infusion by first shaking the vial until
there is no evidence of yellow sediment on the bottom of the vial.
• Transfer the appropriate amount of drug from the required number
of vials into one or more sterile syringesusing an 18-gauge needle.
• Attach the provided 5-micron filter needle to the syringe; inject the

syringe contents through the filter needle, into the appropriate
amount of D5W injection. Each filter needle may be used on the

contents of no more than four 100 mg vials.

AMPHOTERICIN B LIPOSOMAL 50 mg (Amphotericin 12 mL S.W. Only (12.5 4 mg/mL D5W Only 500 mL 3 hrs Use ASAP *IV ONLY *Not compatible w/ N.S.
(AMBISOME®) B Liposomal Dose= 3- (Final Conc: 1-2 mg/mL) *FLUSH IV Line with D5W BEFORE & AFTER Inf. If this cannot be
5mg/kg/day) mL) (Final Conc.forPeds:0.2- *Injection of AmBisome should commence within 6 hours of done, then a separate IV line must be used. Send 10 mL DEXTROSE
dilution with 5% Dextrose Injection.
0.5mg/mL) FLUSHSYRINGESfor eachdose(1before/1afterdose)
*The reconstituted vial: stored for up to 24 hrs @ Refrig. * SEND TPN 1.2 MICRON FILTER.
*Unopened vials of lyophilized material to be stored @ *RECONSTITUTION:

temperature up to 25° C 1. Add 12 mL of S.W. to AmBisome (Conc. 4mg/mL)
2. Immediately SHAKE THE VIAL VIGOROUSLY for 30 seconds to

completely disperse the AmBisome.
**FILTRATION & DILUTION:

1. After Reconstiitution, withdraw the amount of reconstituted
AmBisome into a sterile syringe.

2. Attach the 5-micron filter provided to the syringe. Inject the
syringe contents through the filter, into the amount of 5% Dextrose.

(Use only 1filter/vial.)
3. AmBisome s/b diluted with 5% Dextrose to a final conc. 1 -2
mg/mL prior to administration. DISCARD PARTIALLY USED VIALS.

AZITHROMYCIN (ZITHROMAX®) 500 mg 4.8 mL (5 mL) 100MG/ML NS, D5W 250 mL 90 mins 24 hrs 7 days Refrigerate *IV ONLY
AZTREONAM (AZACTAM®) 1 Gm 10 mL 100 mg/mL NS, D5W (Max Conc: 2 mg/mL) 60 mins 48 hrs 7 days Refrigerate *IV or IM *Shake immediately and vigorously
2 Gm 200 mg/mL
100 mL
(Max 20 mg/mL)

400 mg 4.8 mL (5 mL)

2

Med-Plus Pharmacy Inc. LAST UPDATE: 07/30/2019
SterileCompoundingMasterFormula

EQUIPMENT/SUPPLIES TO BE USED: Syringes, Alcohol Prep Pads, Needles, Pharmassist Pump, ISO Class 5 Hood (LAFWs), Exactamix (for TPN) INACTIVE INGREDIENTS: n/a
CLEAN ROOM GEAR TO BE USED: Bouffant Cap, Mask, Gown, Gloves, Shoe Cover ACTIVE DRUG IN LIQUID FORM:
STEPS IN PREPARING PRODUCT: ACTIVE DRUG IN POWDER FORM 1) Withdraw exact amount of active ingredient
1) Using ASEPTIC TECHNIQUE (w/ minimizing coring), reconstitute powder with STERILE WATER unless indicated otherwise. SHAKE WELL until completely dissolved 2) Add withdrawn amount and inject into prescribed solution listed in this table Inspect final product.
EXCEPT following drugs: CUBICIN®, COLISTIN®, RIFAMPIN®, TYGACIL® (Swirl the vial until the drug is dissolved) 3) Pharmacist to verify the accuracy of the drug, amount of active ingredient and solution
2) Inspect reconstituted solution visually to make sure the powder is completely dissolved. 4) Label bag
3) Add reconstituted solution into prescribed solution listed in table, again minimizing coring. **BUD (Beyond Use Date) Reference: ASHP's Handbook on Injectable Drugs, 18th edition & the United States Pharmacopeia (USP) Chapter <797>
4) Inspect final product. Pharmacist to verify the accuracy of the drug, amount of active ingredient and solution. 5) Label bag Pharmaceutical Compounding – Sterile Preparations, Title 16 CCR 1751 et seq.

RECONSTITUTION FINAL FLUID INFUSION STABILITY (BUD)**
(Withdrawl Vol) CONC. VOLUME RATE
DRUG STRENGTH FLUID LABEL Comments
CASPOFUNGIN (CANCIDAS®) 50 mg NS Only 250 mL 90 mins
70 mg (NTE 0.5 mg/mL) ROOM TEMP. REFRIG.
CEFAZOLIN 500 mg
(ANCEF®, KEFZOL®) 1 Gm 10 mL N.S. Only 5 mg/mL 24 hrs 48 hrs Refrigerate *Unreconstituted vial: REFRIGERATE
7 mg/mL *Reconstituted solution: up to 1 hr @ R.T.
CEFEPIME (MAXIPIME®) 10 Gm 5 mL
9.6 mL (10 mL) 100 mg/mL NS, D5W 100 mL 60 mins 24 hrs 10 days Refrigerate *Unreconstitued Vial: PROTECT FROM LIGHT
1 Gm 45 mL (51 mL) 200 mg/mL (Max Conc: 20 mg/mL) *Reconstitued Vial: stable for 24 hrs @ Room Temp, 10 days
2 Gm 96 mL (102 mL) 100 mg/mL
@ Refrig.
*Cefazolin 10Gm Bulk Vial: Discard vial within 4 hours after

initial entry
*For I.M. Cefazolin 1gm: add 2.5mL S.W., shake well,

withdraw entire contents, provides volume ~3mL
(approximate Conc. 330mg/mL)

10 mL 100 mg/mL NS, D5W 100 mL 60 min. 24 hrs 7 days Refrigerate *Unreconstitued Vial: PROTECT FROM LIGHT
200 mg/mL *Reconstitued Vial: 24 hrs @ Room Temp, 7 days @ Refrig.
*IM only for mild to mod. uncomplicated or complicated UTI’s

due to E. coli when the IM is a more appropriate route.

CEFOTAXIME (CLAFORAN®) 1 Gm 9.6 mL (10 mL) 100 mg/mL NS, D5W 100 mL 60 min. 24 hrs 5 days Refrigerate *Reconstituted Vial: stable for 12 hrs @ Room Temp, 7 days
2 Gm 9.4 mL (10 mL) 200 mg/mL @ Refrig. *PROTECT FROM LIGHT

1 Gm 9.5mL (10 mL) 100 mg/mL
2 Gm 19mL (20 mL)
CEFOTETAN (CEFOTAN®) NS, D5W 100 mL 60 min. 24 hrs 96 hrs Refrigerate Reconstituted Vial: stable for 24 hrs @ Room Temp, 96 hrs @
Refrig. *PROTECT FROM LIGHT
60 min. 18 hrs
10GM BULK VIAL 50 (55 mL) or 180 or 95 mg/mL 90 min. 6 hrs
60 min. 12 hrs
100 mL (105 mL)

CEFOXITIN (MEFOXIN®) 1 Gm 10 mL (10.5 mL) 95 mg/mL NS, D5W 100 mL 48 hrs Refrigerate Reconstituted Vial: stable for 6 hrs @ Room Temp,
2 Gm 10 mL (11.1 mL) 180 mg/mL 1 WEEK @ Refrig.

CEFTAROLINE (TEFLARO®) 400 mg 20 mL 20 mg/mL NS, D5W 250 mL 24 hrs Refrigerate *Mix gently to constitute, then look closely to see that the
3 days contents have dissolved completely. Constitution time is < 2
CEFTAZIDIME (FORTAZ®, 600 mg 5.3ML (5.7ML) 30 mg/mL
TAZICEF®) 500 mg 10ML (10.8ML) 100 mg/mL minutes. *IV USEONLY
1 Gm 10ML (11.5ML) 100 mg/mL
2 Gm 170 mg/mL NS, D5W 100 mL Refrigerate *Reconsituted Vial: stable for 12 hrs @ Room Temp,
(Max Conc: 40 mg/mL) 3 DAYS @Refrig.

*PROTECT FROM LIGHT

3

Med-Plus Pharmacy Inc. LAST UPDATE: 07/30/2019
SterileCompoundingMasterFormula

EQUIPMENT/SUPPLIES TO BE USED: Syringes, Alcohol Prep Pads, Needles, Pharmassist Pump, ISO Class 5 Hood (LAFWs), Exactamix (for TPN) INACTIVE INGREDIENTS: n/a
CLEAN ROOM GEAR TO BE USED: Bouffant Cap, Mask, Gown, Gloves, Shoe Cover ACTIVE DRUG IN LIQUID FORM:
STEPS IN PREPARING PRODUCT: ACTIVE DRUG IN POWDER FORM 1) Withdraw exact amount of active ingredient
1) Using ASEPTIC TECHNIQUE (w/ minimizing coring), reconstitute powder with STERILE WATER unless indicated otherwise. SHAKE WELL until completely dissolved 2) Add withdrawn amount and inject into prescribed solution listed in this table Inspect final product.
EXCEPT following drugs: CUBICIN®, COLISTIN®, RIFAMPIN®, TYGACIL® (Swirl the vial until the drug is dissolved) 3) Pharmacist to verify the accuracy of the drug, amount of active ingredient and solution
2) Inspect reconstituted solution visually to make sure the powder is completely dissolved. 4) Label bag
3) Add reconstituted solution into prescribed solution listed in table, again minimizing coring. **BUD (Beyond Use Date) Reference: ASHP's Handbook on Injectable Drugs, 18th edition & the United States Pharmacopeia (USP) Chapter <797>
4) Inspect final product. Pharmacist to verify the accuracy of the drug, amount of active ingredient and solution. 5) Label bag Pharmaceutical Compounding – Sterile Preparations, Title 16 CCR 1751 et seq.

RECONSTITUTION FINAL FLUID INFUSION STABILITY (BUD)**
(Withdrawl Vol) CONC. VOLUME RATE
DRUG STRENGTH FLUID LABEL Comments

ROOM TEMP. REFRIG.

CEFTAZIDIME + AVIBACTAM 2.5 Gm 10 mL (12mL) Ceftazidime 0.167 NS, D5W 250 mL 2 hours 12 hrs 24hrs Refrigerate * Volume to withdraw from constituted vial:
(AVYCAZ®) (2 gm Ceftazidime and g/mL & Avibactam Fordose of 2.5 gm (12 mL entire content),
1.25 gm (1 g ceftazidime & 0.25 g avibacta: 6 mL),
0.5 gm avibactam) 0.042 g/mL 0.94 gm (0.7 5g ceftazidime & 0.19 g avibactam: 4.5 mL)

*IVPB only
* NO IV-push *PROTECT FROM LIGHT

CEFTOLOZANE + TAZOBACTAM 1.5 Gm (1g + 0.5g) 10 mL (entire contents Ceftolozane NS, D5W 100 mL 1 hour 24 hrs 7days Refrigerate * 1.5gm vial contains 1 g of ceftolozane and 500 mg of
(ZERBAXA®) 11.4mL) 0.0877 g/mL& Refrigerate tazobactam
dose of 750mg Tazobactam NS, D5W 100 mL 60 min. 2 days 10 days *reconstituted soluntion may be stored for 1 hour prior to
CEFTRIAXONE (ROCEPHIN®) (500mg +250mg) 5.7mL to withdraw 0.0439 g/mL NS, D5W (Max Conc: 40mg/mL) 60 min. 24 hrs 7 days
dose of 375mg D5W* 60 min. Use Immediately 14 days further dilution. Do not freeze
CEFUROXIME (ZINACEF®, (250mg +125mg) 2.9 mL to withdraw preferred, 100 mL once overwrap is * Diluted solution: 24 hours @ Room Temp or 7 days @
KEFUROX®, CEFTIN®) 60 min. removed 14days Refrigeration
dose of 150mg 1.2 mL to withdraw NS Max Conc: 2 mg/mL (NTE 30 *ZERBAXA vials should be stored refrigerated at 2 to 8°C (36
CIPROFLOXACIN (100mg + 50mg) mg/min.) 48 hrs
(CIPRO®) 2.4 mL (2.5 mL) 100 mg/mL NS, D5W 100 mL to 46°F) and PROTECTED FROM LIGHT.
250 mg 4.8 mL (5 mL) 100 mg/mL (Max Conc: 18 mg/mL)
500 mg 9.6 mL (10 mL) *Powder Vial: PROTECT FROM LIGHT
1 Gm 19.2 mL (20 mL) *After Reconstitution, No Protection from light Necessary
*Reconstituted solutions may be stored for 2 days at room
2 Gm 7ML
14ML temp or for 10 days in the refrig.
750 mg
Refrigerate Unreconstituted Vial: PROTECT FROM LIGHT, 24 hrs @ Room
1.5 Gm Temp, 7 DAYS @ Refrig.

200 mg/100mL Ready-To-Use Bag 2 mg/mL Room Temp *Single dose flexible plastic container.
DEXTROSE *Do NOT remove unit from overwrap until ready for use.

400 mg/200mL *PROTECT FROM LIGHT.
DEXTROSE *PROTECT FROM FREEZING

600 mg/4mL vial 150 mg/mL Refrigerate *Infusion rates should not exceed 30 mg/minute
900 mg/6mL vial 150 mg/mL compounded *CLEOCIN PHOSPHATE IV Solution in Galaxy plastic
containers is a sterile solution of clindamycin phosphate with
CLINDAMYCIN (CLEOCIN®) 300 mg/50mL _ 6 mg/mL Room temp
(premix bags) 5% dextrose, s/b stored @ ROOM TEMP.
600 mg/50mL 12 mg/mL

900mg/50mL 18 mg/mL

COLISTIMETHATE (COLISTIN®) 150 mg 2ML S.W. Only 75 mg/mL NS, D5W, 100 mL 60 min. 24 hrs 24 hrs Refrigerate *SWIRL GENTLY TO AVOID FROTHING
D51/2NS *If not used immediately, store Reconstituted solution in
REFRIGERATOR or @ ROOM TEMP & use within 7 DAYS

*SINGLE USE VIAL

4

Med-Plus Pharmacy Inc. LAST UPDATE: 07/30/2019
SterileCompoundingMasterFormula

EQUIPMENT/SUPPLIES TO BE USED: Syringes, Alcohol Prep Pads, Needles, Pharmassist Pump, ISO Class 5 Hood (LAFWs), Exactamix (for TPN) INACTIVE INGREDIENTS: n/a
CLEAN ROOM GEAR TO BE USED: Bouffant Cap, Mask, Gown, Gloves, Shoe Cover ACTIVE DRUG IN LIQUID FORM:
STEPS IN PREPARING PRODUCT: ACTIVE DRUG IN POWDER FORM 1) Withdraw exact amount of active ingredient
1) Using ASEPTIC TECHNIQUE (w/ minimizing coring), reconstitute powder with STERILE WATER unless indicated otherwise. SHAKE WELL until completely dissolved 2) Add withdrawn amount and inject into prescribed solution listed in this table Inspect final product.
EXCEPT following drugs: CUBICIN®, COLISTIN®, RIFAMPIN®, TYGACIL® (Swirl the vial until the drug is dissolved) 3) Pharmacist to verify the accuracy of the drug, amount of active ingredient and solution
2) Inspect reconstituted solution visually to make sure the powder is completely dissolved. 4) Label bag
3) Add reconstituted solution into prescribed solution listed in table, again minimizing coring. **BUD (Beyond Use Date) Reference: ASHP's Handbook on Injectable Drugs, 18th edition & the United States Pharmacopeia (USP) Chapter <797>
4) Inspect final product. Pharmacist to verify the accuracy of the drug, amount of active ingredient and solution. 5) Label bag Pharmaceutical Compounding – Sterile Preparations, Title 16 CCR 1751 et seq.

RECONSTITUTION FINAL FLUID INFUSION STABILITY (BUD)**
(Withdrawl Vol) CONC. VOLUME RATE
DRUG STRENGTH FLUID LABEL Comments

ROOM TEMP. REFRIG.

DAPTOMYCIN (CUBICIN®) 500 mg 10ML N.S. Only 50 mg/mL NS Only 100 mL 60 min. 12 hrs 72 hrs Refrigerate *UNRECONSTITUED VIAL: REFRIGERATE
*RECONSTITUTED VIAL: 12HRS @R.T., 48HRS @REFRIG
*SLOWLY ADD 0.9% NS AGAINST THE INSIDE WALL OF THE
VIAL, Ensure all of the powder is wetted by gently rotating

the vial.
* Allow the vial to sit undisturbed for 10 minutes.
* GENTLY SWIRL the vial for a few minutes to obtain

complete reconstitution.
*AVOID SHAKING the vial to minimize foaming.

*Incompatible w/ D5W

DEXAMETHASONE SODIUM UPTO 100 mg (stock: _ _ NS, D5W 100 mL 60 min. 24 hrs 24 hrs Room Temp *PROTECT FROM LIGHT
PHOSPHATE (DECADRON®) 10 mg/mL) 10 mg/mL 1 hr 48 hrs
2 hrs
DOXYCYCLINE 100 mg 10 mL NS, D5W 0 to 100 mg: 100 mL 6 hrs 72 hrs Refrigerate *PROTECT FROM LIGHT
60 min.
Up to 200 mg: 250 mL
(Conc: 0.1-1 mg/mL)

ERTAPENEM (INVANZ®) 1 Gm IVPB: 10 mL S.W. or 100 mg/mL NS Only 100 mL 24 hrs Refrigerate *IM: Reconstitute 1gm with 3.2mL Lidocaine 1%, then use
NS. 280 mg/mL within 1 hr after prepration *Storage after dilution: Use
within 6 hours if stored at room temp. The diluted solution
IVP: 3.2ML of 1% may be refrigerated for 24 hours and used within 4 hours
LIDOCAINE
after removal from refrigeration.

500 mg 10ML S.W. only up to 500 mg: 100 mL 1 hr 8 hrs (The final 8 hrs (The final *Reconstitute w/ S.W. only as other diluents may cause
20ML S.W. only NS Only 2 hrs diluted solution of diluted solution of
1 Gm precipitation, reconstituted vial is stable 24hrs @Room Temp,
20 mg 501- 1000 mg: 250 mL s/b completely s/b completely
ERYTHROMYCIN 40 mg 50 mg/mL administered administered Room Temp 14days @Refrig. *The final diluted solution of erythromycin
FAMOTIDINE (PEPCID®) within 8 hrs) within 8 hrs)
lactobionate s/b completely administered within 8 hours in

order to assure proper potency & since it is not suitable for

storage *NO IM. *IV ONLY

20mg IVPB: 100 mL 40mg *IV-Push:Dilute 20mgw/compatible soln to atotal volume
of 5 mL or 10 mL
_ _ NS, D5W IVPB: 250 mL IVPB: 30mins 7 days 48 hrs Room Temp

(Conc. 0.2 mg/mL)

5

Med-Plus Pharmacy Inc. LAST UPDATE: 07/30/2019
SterileCompoundingMasterFormula

EQUIPMENT/SUPPLIES TO BE USED: Syringes, Alcohol Prep Pads, Needles, Pharmassist Pump, ISO Class 5 Hood (LAFWs), Exactamix (for TPN) INACTIVE INGREDIENTS: n/a
CLEAN ROOM GEAR TO BE USED: Bouffant Cap, Mask, Gown, Gloves, Shoe Cover ACTIVE DRUG IN LIQUID FORM:
STEPS IN PREPARING PRODUCT: ACTIVE DRUG IN POWDER FORM 1) Withdraw exact amount of active ingredient
1) Using ASEPTIC TECHNIQUE (w/ minimizing coring), reconstitute powder with STERILE WATER unless indicated otherwise. SHAKE WELL until completely dissolved 2) Add withdrawn amount and inject into prescribed solution listed in this table Inspect final product.
EXCEPT following drugs: CUBICIN®, COLISTIN®, RIFAMPIN®, TYGACIL® (Swirl the vial until the drug is dissolved) 3) Pharmacist to verify the accuracy of the drug, amount of active ingredient and solution
2) Inspect reconstituted solution visually to make sure the powder is completely dissolved. 4) Label bag
3) Add reconstituted solution into prescribed solution listed in table, again minimizing coring. **BUD (Beyond Use Date) Reference: ASHP's Handbook on Injectable Drugs, 18th edition & the United States Pharmacopeia (USP) Chapter <797>
4) Inspect final product. Pharmacist to verify the accuracy of the drug, amount of active ingredient and solution. 5) Label bag Pharmaceutical Compounding – Sterile Preparations, Title 16 CCR 1751 et seq.

RECONSTITUTION FINAL FLUID INFUSION STABILITY (BUD)**
(Withdrawl Vol) CONC. VOLUME RATE
DRUG STRENGTH FLUID 1 hr LABEL Comments
50 mL
NS 1 hr ROOM TEMP. REFRIG.
(compatible 100 mL
100 mg/50mL NS with D5W) 2 hrs *PROTECT FROM FREEZING.
200 mL *Avoid excessive heat.
200 mg/100 mL NS Ready-To-Use Bag _ Use Immediately _ Room Temp
FLUCONAZOLE (DIFLUCAN®) once overwrap is * Intact containers: Refer to the expiration date on the
package
removed
*Maximum IV rate: 200 mg/hr.
400 mg/200 mL NS *Do NOT remove unit from overwrap until ready for use.

*Do NOT Compound (transfer) in pharmacy.
*HAZARDOUS DRUG-DISPOSE PROPERLY.

FUROSEMIDE (LASIX®) 20 mg/2 mL _ _ NS ONLY 100 mL 60 mins 24 hrs _ Room Temp *IV, IV-push, IM
40 mg/4 mL _ _ (max Conc: 10mg/mL) (NTE 4 4 days
GENTAMICIN 100 mg/10 mL mg/min)
(GARAMYCIN®) 40 mg/mL _
80 mg/2mL NS, D5W 100 mL 60 min. 24HRS Refrigerate *IV, IM
100 mg/10mL 24HRS
_
100 mg/2mL ACT-O- 50 mg/mL 24HRS *Diluted solution: stable for 4 hours & PROTECT FROM
VIAL 125 mg/mL (Conc. 1mg/mL) LIGHT, s/b given IVPB or IV-PUSH.

HYDROCORTISONE SODIUM 2 mL Bacteriostatic *Unused solution s/b discarded after 3 days.
SUCCINATE (SOLU-CORTEF®) 250 mg /2mL ACT-O- N.S. provided in ACT-O- *Press down on plastic activator to force diluent (2 mL
VIAL NS, D5W 100 mL 60 mins Room Temp Bacteriostatic N.S.) into the lower compartment. Gently
agitate to effect solution. Remove plastic tab covering center
Vial 4HRS of stopper, and sterilize the stopper top. Insert needle
(Conc. 2mg/mL - squarely through center of stopper until tip is just visible.
500 mg/2mL ACT-O-
VIAL 60mg/mL) Invert vial and withdraw dose.

250 mg/mL

IMIPENEM-CILASTATIN 250 mg 10 mL N.S. only 25 mg/mL NS Only up to 500mg: 100 mL 60 mins 4HRS Refrigerate *IV or IM
(PRIMAXIN®) 500 mg 50 mg/mL up to 1 Gm: 250 mL 90 mins 24HRS Room Temp *IV formulation: available in 250mg, 500mg.
15 mins *IM formulation: available in 500mg and 750mg.
LEVETIRACETAM (KEPPRA®) 500 mg/5 mL _ 100MG/ML NS, D5W 100ML
*IM formulation is not for IV use.

*For IV use only.

250 mg/50 mL D5W 250 mg: 50mL 60 mins

Use Immediately *No dilution necessary
*Do NOT remove unit from overwrap until ready for use.
LEVOFLOXACIN (LEVAQUIN®) 500 mg/100 mL D5W Ready-To-Use Bag 5 mg/mL NS, D5W 500 mg: 100 mL 60 mins once overwrap is _ Room Temp
removed

750 mg/150 mL D5W > 500 mg: 150 mL 90 mins

6

Med-Plus Pharmacy Inc. LAST UPDATE: 07/30/2019
SterileCompoundingMasterFormula

EQUIPMENT/SUPPLIES TO BE USED: Syringes, Alcohol Prep Pads, Needles, Pharmassist Pump, ISO Class 5 Hood (LAFWs), Exactamix (for TPN) INACTIVE INGREDIENTS: n/a
CLEAN ROOM GEAR TO BE USED: Bouffant Cap, Mask, Gown, Gloves, Shoe Cover ACTIVE DRUG IN LIQUID FORM:
STEPS IN PREPARING PRODUCT: ACTIVE DRUG IN POWDER FORM 1) Withdraw exact amount of active ingredient
1) Using ASEPTIC TECHNIQUE (w/ minimizing coring), reconstitute powder with STERILE WATER unless indicated otherwise. SHAKE WELL until completely dissolved 2) Add withdrawn amount and inject into prescribed solution listed in this table Inspect final product.
EXCEPT following drugs: CUBICIN®, COLISTIN®, RIFAMPIN®, TYGACIL® (Swirl the vial until the drug is dissolved) 3) Pharmacist to verify the accuracy of the drug, amount of active ingredient and solution
2) Inspect reconstituted solution visually to make sure the powder is completely dissolved. 4) Label bag
3) Add reconstituted solution into prescribed solution listed in table, again minimizing coring. **BUD (Beyond Use Date) Reference: ASHP's Handbook on Injectable Drugs, 18th edition & the United States Pharmacopeia (USP) Chapter <797>
4) Inspect final product. Pharmacist to verify the accuracy of the drug, amount of active ingredient and solution. 5) Label bag Pharmaceutical Compounding – Sterile Preparations, Title 16 CCR 1751 et seq.

RECONSTITUTION FINAL FLUID INFUSION STABILITY (BUD)**
(Withdrawl Vol) CONC. VOLUME RATE
DRUG STRENGTH FLUID LABEL Comments
Ready-To-Use Bag _ D5W 200 mL 90 mins
NS Only 2 hrs ROOM TEMP. REFRIG.
10 mL N.S. or S.W. 50 mg/mL 300 mL
LINEZOLID (ZYVOX®) 400 mg/200 mL 20 mL N.S. or S.W. 60 mins Use Immediately _ Room Temp *PROTECT FROM LIGHT *single-dose container *Do NOT
MEROPENEM (MERREM®) 600 mg/300 mL 100 mL (max conc: once overwrap is freeze. *Do NOT remove unit from overwrap until ready for
20mg/mL)
500 mg removed use.
1 Gm
4 hrs in N.S. 24 hrs in N.S. Refrigerate *Reconstitued Vial with S.W. (up to 50mg/mL): 3 hrs @ Room
Temp,[email protected] *IV-PUSH:dosesupto1gmover3-

5mins * continuous IV *Intermittent IV

40 mg/1mL 1mL Bacteriostatic 40 mg/mL *DO NOT REFRIGERATE / STORE @ ROOM TEMP
Water provided in ACT- *PROTECT FROM LIGHT *May be given IM/IVP/IVPB

O-VIAL *Reconstituted Vial: use within 48 hrs
1.Remove protective cap. 2.Cleanse stopper with suitable
METHYLPREDNISOLONE NS, D5W 50-100mg: 50mL 30 min 24 hrs Do NOT Refrigerate Room Temp
SODIUM SUCCINATE (SOLU- 101-500mg: 100mL as directed germicide.
505-1250mg: 250mL as directed 3. Aseptically add 1 mL Bacteriostatic Water for Inj. USP (with
MEDROL®) benzyl alcohol) for the 40 mg vial or 2 mL Bacteriostatic
Water for Inj., USP (with benzyl alcohol) for the 125 mg vial.
125 mg/2mL 2mL Bacteriostatic 62.5 mg/mL
Water provided in ACT- 4. Agitate to effect solution. 5.Invert vial. Insert needle
through target area of stopper until tip is just visible.
O-VIAL *EQUIVAENCY: Methylpred dose/0.8 = Prednisone dose

METOCLOPRAMIDE (REGLAN®) 10 mg/2 mL _ _ NS, D5W 100 mL 60 mins 48 hrs 48 hrs Refrigerate *PROTECT FROM LIGHT
60 mins _
METRONIDAZOLE (FLAGYL®) 500 mg/100 mL Ready-To-Use Bag 5 mg/mL NS Only 100 mL Use Immediately _ Room Temp *PROTECT FROM LIGHT *Protect from freezing *Single-dose
once overwrap is _ container *Do NOT remove unit from overwrap util ready for

removed 7 days use.

MICAFUNGIN (MYCAMINE®) 50 mg N.S. 50 mg/mL NS, D5W 100 mL 60 mins 24 hrs 48 hrs Room Temp *Reconstituted Vial: stable for 24hrs @ Room Temp
100 mg *PROTECT FROM LIGHT

MOXIFLOXACIN (AVELOX®) 400 mg/250mL Ready-To-Use Bag _ 0.8% saline 250 mL 90 mins Use Immediately Room Temp *DO NOT REFRIGERATE - product precipitates upon
premix bag once overwrap is refrigeration

removed *Do not remove unit from overwrap until ready for use.

NAFCILLIN (NAFCIL®, UNIPEN®) 500 mg 1.7 mL 250 mg/mL NS, D5W 100 mL 60 mins 24 hrs Refrigerate * Reconstituted vial: stable for 3 days at Room Temp, 7 days
1 Gm 9.6 mL 100 mg/mL (max Conc: 40 mg/mL) @ Refrig. or 12 weeks when frozen
2 Gm 19.2 mL 100 mg/mL * For I.V. inf in NS or D5W, stable for 24 hours at Room Temp,
96 hrs @ Refrig.

NEOMYCIN & POLYMIXIN B 40 mg Neomycin, _ _ NS Only 1000 mL over 24 hrs _ Refrigerate *REFRIGERATEampules (undiluted vial) &Mixed Irrigation
SULFATE 200,000units Solution

Polymyxin B/mL *PROTECT ampules FROM LIGHT
*IRRIGATION USE ONLY (Urinary Bladder Irrigation)
*ThemixedIrrigationSolutions/brefrigerated &usedwithin

48 hrs

7

Med-Plus Pharmacy Inc. LAST UPDATE: 07/30/2019
SterileCompoundingMasterFormula

EQUIPMENT/SUPPLIES TO BE USED: Syringes, Alcohol Prep Pads, Needles, Pharmassist Pump, ISO Class 5 Hood (LAFWs), Exactamix (for TPN) INACTIVE INGREDIENTS: n/a
CLEAN ROOM GEAR TO BE USED: Bouffant Cap, Mask, Gown, Gloves, Shoe Cover ACTIVE DRUG IN LIQUID FORM:
STEPS IN PREPARING PRODUCT: ACTIVE DRUG IN POWDER FORM 1) Withdraw exact amount of active ingredient
1) Using ASEPTIC TECHNIQUE (w/ minimizing coring), reconstitute powder with STERILE WATER unless indicated otherwise. SHAKE WELL until completely dissolved 2) Add withdrawn amount and inject into prescribed solution listed in this table Inspect final product.
EXCEPT following drugs: CUBICIN®, COLISTIN®, RIFAMPIN®, TYGACIL® (Swirl the vial until the drug is dissolved) 3) Pharmacist to verify the accuracy of the drug, amount of active ingredient and solution
2) Inspect reconstituted solution visually to make sure the powder is completely dissolved. 4) Label bag
3) Add reconstituted solution into prescribed solution listed in table, again minimizing coring. **BUD (Beyond Use Date) Reference: ASHP's Handbook on Injectable Drugs, 18th edition & the United States Pharmacopeia (USP) Chapter <797>
4) Inspect final product. Pharmacist to verify the accuracy of the drug, amount of active ingredient and solution. 5) Label bag Pharmaceutical Compounding – Sterile Preparations, Title 16 CCR 1751 et seq.

RECONSTITUTION FINAL FLUID INFUSION STABILITY (BUD)**
(Withdrawl Vol) CONC. VOLUME RATE
DRUG STRENGTH FLUID 100 mL ROOM TEMP. REFRIG. LABEL Comments
_ _ NS, D5W 250 mL Room Temp
OCTREOTIDE ACETATE 0-200 mcg 250 mL 60-90 mins 24 hrs _ * REFRIGERATE AMPULES & MULTIPLE-DOSE VIAL
(SANDOSTATIN®) 600 mcg 50 mL (use within 14 days)
1250 mcg
100 mL *PROTECT AMPULES FROM LIGHT
*IV & SUB-Q ONLY
500-1000 mL
ONDANSETRON (ZOFRAN®) 4 mg/mL _ _ NS, D5W 15 mins 24 hrs 24 hrs Room Temp *PROTECT FROMLIGHT *stable @roomtemp for 48hrs after
dilution with NS, D5W. However, after dilution, do not use

beyond 24hrs (b/c diluents generally do not conttaine
preservative).

500 mg 5 mL 10-100mg/mL: 4 days 10-100mg/mL: 7
1 Gm 10 mL
2 Gm 20 mL in NS days in NS *Reconstitued Vial: Stable for 7 days @ Refrig,
4 Gm 40 mL 4 days @ Room Temp.
OXACILLIN 10 Gm 93 mL 100 mg/mL NS, D5W 60 mins 0.5-2mg/mL: 6 hrs in 10-30mg/mL:4days Refrigerate
PAMIDRONATE (AREDIA®) 30 mg Exception to 10 Gm vial stable for 4 hrs @ Refrig
10 mL D5W in D5W
90 mg
10-30mg/mL: 24 hrs 10-30mg/mL:4days

in D51/2NS in D51/2NS

3 mg/mL NS, D5W 24 hrs 24 hrs 24 hrs Refrigerate *IV via slow IV infusion *IV inf.: due to renal toxicity risk,
9 mg/mL single dose not to exceed 90mg and IV inf. duration s/b 2-
24hrs. *Admin. in an IV line separate from all other drugs.

PANTOPRAZOLE (PROTONIX®) 40 mg 10 mL NS only 4 mg/mL NS, D5W 100 mL 60 mins 6 hrs 24 hrs Room Temp * Reconstituted Vial: stable for 6 hrs @ Room Temp
Dose 80mg: 250 mL 24 hrs *IV Infusion s/ b used within 24 hrs from the time of initial
90mins
(7 mL/min.) 24 hrs reconstitution.
_ *PROTECT THE VIAL FROM LIGHT

PENICILLIN G POTASSIUM (PEN 5 Million Units 8.2 mL 500,000 units/mL NS, D5W 100 mL 60 mins 48 hrs 7 days Refrigerate *Reconstitued 5 MU vial: stable for 3 days @ Refrig,
G K®) 10 Million Units (Max Conc: 90 mg/mL) ¾ 20 MU vial: stable for 7 days @ Refrig
20 Million Units 16 mL
100 mL 60mins
2.25 Gm 33 mL 225 mg/mL *Reconstituted Vial: stable for 24hrs @ Room temp, 48 hrs @
3.375 Gm (Piperacillin
PIPERACILLIN/TAZOBACTAM 10 mL 200mg/mL NS, D5W 7 days Refrigerate Refrig. *Bulk Vial:
(ZOSYN®) 4.5 Gm 15 mL Tazobactam
20 mL 25 mg/mL) 24hrs @ Room Temp, 48hrs @ Refrig. *Ambulatory IV
152 mL
(180mL total) infusion pump (Cadd pump): 12 hrs @ Room Temp.

40.5 Gm Bulk Vial

POLYMYXIN B 500,000 Units/Vial 10 mL 50,000 Units/mL D5W only 500 mL 3 hrs 72 hrs Refrigerate *PROTECT FROM LIGHT
_ *After Reconstitution: Refrigerate, any unused portion should

be discarded after 72 hrs

RANITIDINE (ZANTAC®) 50 mg/2mL _ _ NS, D5W 100 mL 60 mins Room Temp. *PROTECT THE VIAL FROM LIGHT

8

Med-Plus Pharmacy Inc. LAST UPDATE: 07/30/2019
SterileCompoundingMasterFormula

EQUIPMENT/SUPPLIES TO BE USED: Syringes, Alcohol Prep Pads, Needles, Pharmassist Pump, ISO Class 5 Hood (LAFWs), Exactamix (for TPN) INACTIVE INGREDIENTS: n/a
CLEAN ROOM GEAR TO BE USED: Bouffant Cap, Mask, Gown, Gloves, Shoe Cover ACTIVE DRUG IN LIQUID FORM:
STEPS IN PREPARING PRODUCT: ACTIVE DRUG IN POWDER FORM 1) Withdraw exact amount of active ingredient
1) Using ASEPTIC TECHNIQUE (w/ minimizing coring), reconstitute powderwith STERILE WATER unless indicated otherwise. SHAKE WELL until completely dissolved 2) Add withdrawn amount and inject into prescribed solution listed in this table Inspect final product.
EXCEPT following drugs: CUBICIN®, COLISTIN®, RIFAMPIN®, TYGACIL® (Swirl the vial until the drug is dissolved) 3) Pharmacist to verify the accuracy of the drug, amount of active ingredient and solution
2) Inspect reconstituted solution visually to make sure the powder is completely dissolved. 4) Label bag
3) Add reconstituted solution into prescribed solution listed in table, again minimizing coring. **BUD (Beyond Use Date) Reference: ASHP's Handbook on Injectable Drugs, 18th edition & the United States Pharmacopeia (USP) Chapter <797>
4) Inspect final product. Pharmacist to verify the accuracy of the drug, amount of active ingredient and solution. 5) Label bag Pharmaceutical Compounding – Sterile Preparations, Title 16 CCR 1751 et seq.

RECONSTITUTION FINAL FLUID INFUSION STABILITY (BUD)**
(Withdrawl Vol) CONC. VOLUME RATE
DRUG STRENGTH FLUID LABEL Comments
RIFAMPIN ® 100 mL 60 mins
ROOM TEMP. REFRIG.

600 mg 10 mL 60 mg/mL NS Only 24 hrs _ Room Temp. *SWIRL GENTLY TO DISSOLVE
*Reconstituted Vial: stable for 24 hrs @ Room Temp

*PROTECT FROM LIGHT

62.5 mg/5mL Ampule *If diluted in saline, Use ASAP After Dilution
**Max 125 mg
SODIUM FERRIC GLUCONATE _ _ NS ONLY 5mL (62.5mg) / 250mL 1.5 hr 24 hrs _ Room Temp. *Do NOT infuse w/ TPN or any IV fluid other than NS
(FERRLECIT®) Elemental IRON/dose
(10 mL FERRLECIT®) 10mL (125mg) / 500mL 3 hrs *Ferrlecit® may be administered undiluted as a SLOW IV

inj.(at a rate of up to 12.5 mg/min).

TIGECYCLINE (TYGACIL®) 50 mg 5.3 mL NS only 10 mg/mL NS ONLY 100 mL 60 mins 24 hrs 48 hrs Refrigerate *Tygacil should NOT be reconstituted with S.W.
(withdrawal vol: 5mL (Max Conc: 1 mg/mL) 24 hrs *The vial should be GENTLY SWIRLED until the drug dissolves.
due to 6% overage) 4 hrs
24 hrs *Reconstituted Vial: stable for 6 hrs @ Refrig.

TOBRAMYCIN 40 mg/mL _ _ NS, D5W 100 mL 60 mins 4 days Refrigerate *Reconstituted Vial: stable for 96 hrs @ Refrig., 24hrs @
1.2 Gm Powder 30mL 40 mg/mL _ Room Temp

0 to 80 mg TMP _ 100 mL 60 mins 14 days *Stock: 80 mg-16mg/mL *Min Conc. of diluent bag: 80 mg

10 mL 90 mins TMP/75 mL
20 mL
TRIMETHOPRIM/SULFAMETHOX 81 to 120 mg TMP 150 to 250 mL 90 mins *After initial entry into the vial, the remaining contents must
AZOLE (SMX-TMP DS®, 121 to 240 mg TMP 250 mL
BACTRIM® SEPTRA®) _ D5W only 500 mL 2 hrs Room Temp be used within 48hrs *The solution should be
50 mg/mL
1 hr mixed just prior to use and should be administered within 2
1.5 hrs
hours. *If a dilution of 5 mL per 100 mL of 5%
2 hrs
241 to 450 mg TMP 3 hrs dextrose in water is desired, it s/b used within 4 hours.

VANCOMYCIN (VANCOCIN®) 500 mg NS, D5W < or = 500 mg: 100 mL Refrigerate *Reconstituted Vial: stable for 96hrs @ Refrig *Bulk Vials
1 Gm (MaxConc: 5 > 501~1499 mg: 250 mL (5gm & 10gm):MAX of 4HRS from initial penetration may be
allowed to complete fluid aliquoting/transferring operations
mg/mL) 1500 mg: 250 mL
1501 mg: 500 mL before discarding the container.

9

Med-Plus Pharmacy Inc. LAST UPDATE: 07/30/2019
SterileCompoundingMasterFormula

EQUIPMENT/SUPPLIES TO BE USED: Syringes, Alcohol Prep Pads, Needles, Pharmassist Pump, ISO Class 5 Hood (LAFWs), Exactamix (for TPN) INACTIVE INGREDIENTS: n/a
CLEAN ROOM GEAR TO BE USED: Bouffant Cap, Mask, Gown, Gloves, Shoe Cover ACTIVE DRUG IN LIQUID FORM:
STEPS IN PREPARING PRODUCT: ACTIVE DRUG IN POWDER FORM 1) Withdraw exact amount of active ingredient
1) Using ASEPTIC TECHNIQUE (w/ minimizing coring), reconstitute powder with STERILE WATER unless indicated otherwise. SHAKE WELL until completely dissolved 2) Add withdrawn amount and inject into prescribed solution listed in this table Inspect final product.
EXCEPT following drugs: CUBICIN®, COLISTIN®, RIFAMPIN®, TYGACIL® (Swirl the vial until the drug is dissolved) 3) Pharmacist to verify the accuracy of the drug, amount of active ingredient and solution
2) Inspect reconstituted solution visually to make sure the powder is completely dissolved. 4) Label bag
3) Add reconstituted solution into prescribed solution listed in table, again minimizing coring. **BUD (Beyond Use Date) Reference: ASHP's Handbook on Injectable Drugs, 18th edition & the United States Pharmacopeia (USP) Chapter <797>
4) Inspect final product. Pharmacist to verify the accuracy of the drug, amount of active ingredient and solution. 5) Label bag Pharmaceutical Compounding – Sterile Preparations, Title 16 CCR 1751 et seq.

RECONSTITUTION FINAL FLUID INFUSION STABILITY (BUD)**
(Withdrawl Vol) CONC. VOLUME RATE
DRUG STRENGTH FLUID LABEL Comments

ROOM TEMP. REFRIG.

Dose 200 - 400 mg 100 mL *Single Dose Vial
*Reconstituted Vial: USE ASAP. If not used immediately, ok
VORICONAZOLE (VFEND®) 19 mL (20 mL) 10 mg/mL NS, D5W 1-2 hrs _ 24 hrs Use immediately
_ 20 mg/mL (Max for 24 hrs @Refrig.
Above 400 mg 250 mL 3mg/kg/hr) *INCOMPATIBLE w/ Sodium Bicarbonate IV
*Do NOT mix of co-infuse with other meds or TPN.
** Stock: 200 mg (Max Conc: 5 mg/mL) *HAZARDOUS DRUG-DISPOSE PROPERLY
100 mL
250 mL *Do NOT Compound in pharmacy
*RN to ADD to bag PRIOR to infusion

100 mg *Slow IV injection or Continuous IV infusion

300 mg - 500 mg *SINGLE USE VIAL (Discard any unused portion)

IRON SUCROSE (VENOFER®) **Stock: NS ONLY 7 days _ Room Temp *Do NOT DILUTE to Conc. < 1mg/mL.
50 mg Elemental
> 15mins *Slow IV injection: 100—200 mg of undiluted solution (100
Iron/2.5mL
100 mg Elemental _ mg per 5 mL) may be administered by slow IV injection (into

Iron/5mL the dialysis line for hemodialysis patients) over 2—5 minutes.
200 mg Elemental

Iron/10mL

10


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