BioSil Detailer v2_revisions_082120

BioSil R











Advanced
Collagen Generator




Choline-Stabilized Orthosilicic Acid (ch-OSA )
®
Food Supplement Capsule

Weak Strong

Collagen Matrix Collagen Matrix























Low Density Collagen High Density Collagen
Low Quality Collagen High Quality Collagen
Single-Directional Collagen Multi-Directional Collagen






































† THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION.
THIS PRODUCT IS NOT INTENDED TO TREAT, CURE OR PREVENT ANY DISEASE.

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BioSil When Supplementation Becomes Necessary







Facts about Collagen Loss


1) Starting at age 21, collagen and elastin decline 6) Smoking, stress and poor nutrition all contribute
by 1.00% to 1.50% each year to loss of collagen and elastin.

2) A woman’s skin decreases in thickness 7% 7) Skin can lose up to 80% of its thickness due to loss
every 10 years after the age of 21 of collagen and elastin.


3) In the first 5 years following menopause, 8) Loss of collagen and elastin impacts the proper
collagen declines 6% per year functioning of organs and eyes.

4) Decline in estrogen causes loss of collagen. 9) High levels of homocysteine breakdown collagen

5) Exposure to the sun is one of the biggest 10) Loss of collagen affects bones as well. Collagen loss
contributors to damaged skin collagen causes reduced bone mineral density and brittle bones








Recommended for:

> Thinning hair

> Hair that breaks easily

> Dull hair
> Fine lines and wrinkles

> Loss of skin elasticity

> Sagging skin
> Photo damaged skin

> Glycation-induced skin damage

> Dull-looking skin
> Nails that chip easily










Age 21, start of the decline in collagen

Menopause

Age 30 45 60






† THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION.
THIS PRODUCT IS NOT INTENDED TO TREAT, CURE OR PREVENT ANY DISEASE.

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BioSilWhat is ch-OSA ?
®











• ch-OSA stands for: Choline – Stabilized Orthosilicic Acid
®



• ch-OSA triggers the biological pathways that naturally produce collagen,
®


elastin and keratin.




• Choline neutralizes homocysteine – the “anti-collagen” amino acid




• Homocysteine is an amino acid which is continuously being produced and



broken down in your body.




• Accumulation of homocysteine has a negative impact on collagen



• Homocysteine damages existing bone and decreases the ability to make new bone








































† THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION.
THIS PRODUCT IS NOT INTENDED TO TREAT, CURE OR PREVENT ANY DISEASE.

Physiological Effects
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BioSil Improving Physical Characteristics









Skin

Weak Collagen Matrix Strong Collagen Matrix
Single Directional Multi Directional


Fig. 1







BioSil Clinical Trial BioSil Clinical Trial
Baseline After 20 weeks

Fig. 2











Hair Hair Shaft Hair Shaft

Insufficient Keratin Optimal Keratin


Fig. 3





Fig. 4











Nails Insufficient Keratin Optimal Keratin
Strong Nails
Weak Nails



Fig. 5












† THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION.
THIS PRODUCT IS NOT INTENDED TO TREAT, CURE OR PREVENT ANY DISEASE.

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BioSil HAIR • SKIN • NAILS










Increase in Skin Reduction of Fine Lines Decrease in Nail
Elasticity 89.0% and Wrinkles 30.0% Brittleness

Improvement in Skin Elasticity Improvement in Wrinkle Depth Decrease in Nail Brittleness
First 20 Weeks 25 First 20 Weeks 1.0 0.96 First 20 Weeks
Percent Improvement in Isotrophy -10 0 ch-OSA with BioSil ch-OSA Percent Improvement in Wrinkle Depth 20 5 0 +19* with BioSil ch-OSA Brittleness (VAS) 0.9 0.71 Decrease
50
+45*
40
30%
30
89%
15
In Brittleness
20
0.8
Net Improvement
with
10
Net Improvement
10
BioSil’s ch-OSA
0.7
0.6
-20
-30
-11
0.4
-40
-50 -44 -10 -5 Placebo ch-OSA 0.5 Placebo ch-OSA
Placebo * p<0.05 versus placebo -15 * p<0.05 versus placebo * p<0.05 versus placebo
Increase in the Diameter Increase in Hair Tensile
of Hair Shaft 12.8% Strength 13.1%
Improvement in Hair Thickness Improvement in Hair Strength
First 36 Weeks .73 First 36 Weeks
Cross Sectional Area (mm 2 x 10 3 ) 3.2 2.81 3.17* with BioSil ch-OSA Break Load (N) .70 .69* with BioSil ch-OSA
3.4
12.8%
13.1%
3.0
Net Improvement
Net Improvement
2.8
.65
2.6
2.4
.60
2.2
.58 .61
2.0
Placebo ch-OSA * p<0.05 versus placebo Placebo ch-OSA * p<0.05 versus placebo



s l a i r T l a c i n i l C n a t S s d r a d


Barel A, Calomme M, Timchenko A, De Paepe K, Demeester N, Rogiers V, • Double Blind, Placebo-controlled, Randomized Clinical Trials
Clarys P, Vanden Berghe D (2005). Effect of oral intake of choline stabilized
orthosilicic acid on skin, nails and hair in women with photodamaged skin. • All Results “Statistically Significant” p < 0.05
Arch Dermatol Res 297: 147-153. • Results published in peer reviewed medical journals with
high Impact Factor
Wickett RR, Kossmann E, Barel A, Demeester N, Clarys P, Vanden Berghe • Safe; 20 plus years of no serious side effects; approved by
DA, Calomme M (2007). Effect of oral intake of choline-stabilized European Food Safety Authority (EFSA)
orthosilicic acid on hair tensile strength and morphology in women with
fine hair. Arch Dermatol Res 299: 499-505.






† THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION.
THIS PRODUCT IS NOT INTENDED TO TREAT, CURE OR PREVENT ANY DISEASE.

BioSil R







































Nutritional information
Amount per Amount per % RENI
daily portion serving
Silicon (as ch-OSA®) (mg) 10 5
Choline (as ch-OSA®) (mg) 200 100
Calories (kcal) 0,003 015 0
Total fat (g) 0 0
Saturated fat (g) 0 0
Trans fat (g) 0 0
Cholesterol (mg) 0 0
Sodium (mg) 0.80 0.40
Total Carbohydrates (g) 0.12 0.06
Dietary fi ber (g) 0.89 0.45
Sugar (g) 0 0
Proteins (g) 0.18 0.09 0.31
*Recommended Energy and Nutrient Intake for Female 30-49 year of age

DIRECTIONS: Take 1 capsule, two times daily.

Ingredients: microcrystalline cellulose,
choline-stabilized orthosilicic acid (ch-OSA®),
hypromellose






Contraindications


Two decades of patient usage has produced no serious side effects. It is recommended that patients consult their
physician if they have kidney problems, are pregnant, lactating, or taking prescription drugs.







† THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION.
THIS PRODUCT IS NOT INTENDED TO TREAT, CURE OR PREVENT ANY DISEASE.

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BioSil Appendix






Strong Collagen Matrix















Fig. 1 Skin microrelief of a 62 year old women (left) and a 22 year old (right) is shown at the forearm. The microrelief in young skin has a
typical multi-directional pattern of shallow lines whereas in older skin lines are oriented in dominant direction and become deeper. (De Paepe K,
Lagarde JM, Gall Y, Roseeuw D, Rogiers V (2000). Microrelief of the skin using a light transmission method. Arch Dermatol Res, 292: 500-510.)


Fig. 2 Skin microrelief of a participant in the clinical trial (Barel et al. 2005) at baseline (left) and after 20 weeks supplementation with ch-OSA ®


(right). A more multi-directional pattern of shallow lines resembling “younger” skin is observed compared to baseline as a result of a dense
collagen network in the dermis. (Barel et al. 2005).


Fig. 3 The hair shaft on the left is under-keratinized, resulting in thin, weak hair. The hair shaft on the right represents the shaft after 36 weeks
of supplementing with BioSil. The number of keratin strands significantly increase and the individual keratin bonds strengthen within the hair. In
clinical trials, BioSil is proven to strengthen hair 13.1% and thicken hair by 12.8%.
Fig. 4 Due to insufficient keratin content, the hair shaft on the left exhibits s jagged edge, and therefore diffuses light, causing dull looking hair. As
BioSil increases keratin production, the shaft plumps out and becomes smooth. Hair then exhibits the quality of reflecting light, and appears shiny.

Fig. 5 The ultimate condition of fingernails begins in the nail root, found beneath the nail cuticle. When cells at the root of the nail grow, the

new nail cells push out the old nail cells. But with insufficient keratin production, the new nail is weak and vulnerable to chipping and cracking.
BioSil increases keratin production and is clinically proven to decrease nail brittleness.





































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