Next Generation Clinic

IVF
+

Genetics
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Next Generation
Clinic

DONATION PROGRAMS OWN EGGS IVF
PATIENT’S PATHWAY: PATIENT’S PATHWAY:

1 Initial contact to NGC – 1 Initial contact to NGC –
[email protected] [email protected]

2 Our coordinator will contact you within 3 working days after the 2 Our coordinator will contact you within
initial application to clarify your request 3 working days after the initial application
to clarify your request
3 Free online consultation with the fertility specialist within soonest
days after your request 3 Free online consultation with the fertility
specialist – within soonest days after your
4 Egg donor matching, confirmation from the clinic about donor’s request
availability, reservation of the donor, timing coordination
4 Arrival for stimulation, egg retrieval to NGC
5 Treatment plan from the doctor will be sent to you within 7 days for 14 days, partner arrives for 1 Day for
after confirmation of a donor and available time frames for sperm freezing
Embryo transfer
5 Egg retrieval, fertilization, cultivation, biopsy
6 One-two days arrival for partner’s sperm collection (If required) and PGT-A (if required)

7 Egg donor’s OPU, eggs fertilization, cultivation, biopsy, freezing, 6 Fresh or frozen ET (in case of frozen ET
PGT-A (1month) preparing locally with own doctor) arriving
for 1 Day to NGC
8 One-two days arrival for frozen ET in the soonest suitable cycle
7 HCG Blood test 9 days after the transfer
9 HCG Blood test 9 days after the transfer

Own eggs Donation
programs programs

• Conventional IVF • Egg donation
• Natural cycle IVF • Sperm donation
• Embryo donation
(modified)
• ICSI, IVM Andrology
• Postponed maternity
• Complex semen
Genetics analysis

• PGT-A by NGS • HBA-test,
• Inherited diseases DNA-fragmentation

carrier screening • Surgical sperm
• Noninvasive prenatal retrieval procedures

testing (NIPT)
• Genetic counseling

International department

DIANA LOBZEVA VALENTINA DENISOVA KSENIA LATKOVA

The Head of international Unit, Fertility Specialist Fertility Nurse
Fertility Specialist
What can inspire me within my job? Having a child is a great happiness. But
..I am extremely happy when I hear that While thinking about this question I imag- sometimes it is impossible without ART.
on the other side of the Earth a little Diana I am glad to be part of a team of profes-
or Margaux or Martin or Kevin was born... ine a new life created with my help. sionals who help people with this. It’s great
and more than happy to feel my relation It is definitely one of the best moments when you take part in creating a new life.
when I can see my patients being happy And then see the happy faces of parents
to this miracle with their babies. Every time when I think
about my work I can not stop to wonder holding baby in their arms
how could it happen, creation of a baby
from small cells and then we can see him
or her coming to the office holding par-

ent’s hands. It’s a miracle!

NIKITA ALEKSANDR MARINA
PECHATKIN MARINICHEV CHALIKOVA

Chief Commercial Officer The International patient Cryobank Director
coordinator

I’m thrilled to be a part of strong and I feel very proud to be a part of the team Only this area, in my opinion, fully combines
motivated team, who helps our patients that fulfills every man’s dream: a healthy the ability to earn money, while performing
achieve their dream of having a baby. We newborn child. In our high-demanding
establish a perfect commitment to quality environment every part of the process mat- a huge social role. I always wanted to
through its extensive donation and sur- ters immensely, and the highest standards see a fertility treatment​in Russia at a new
rogacy programs, premium client service, are set and followed. Right timing, precise qualitative level, which we could be proud of.
information collection and attentiveness Besides, here you can always strive forward,
outstanding physician network, and to details are all important pieces of every as soon as a 100 percent result in treatment​
methodical outcome tracking story of our mutual success. I dearly love has never been achieved by anyone yet
working with our patients, and find reward-
ing to help with every administrative aspect

of the treatment!

Core advantages

DONOR SELECTION CRYOBANK

Online access to the extended profiles with Online catalogue with 300 donor embry-
adult photos. All donors are extensively os, created from donor eggs and donor
screened and have own children sperm. Sperm donation. Tandem cycles

with own and frozen donor eggs

GUARANTEES GESTATIONAL
ASSURANCE SURROGACY

12 donor eggs in each donation All inclusive and multiple attempts
program – the best possible opportunity programs. Perfect accommodations

for a safe and successful pregnancy for gestational carriers

INDIVIDUAL APPROACH EXPERIENCED STAFF

NGC offers full range of IVF services to NGC clinic has modern embryological
achieve a successful pregnancy. Individual equipment and is staffed by leading

treatment plan and coordination reproductologists and embryologists with
15 years of average experience

Advantages of treatment at NGC

Own genetics lab - full NextGen21 test + SMA he-
spectrum of investigations. 2 reditary diseases screening
Illumina Miseq
sequencers Largest Russian cryobank
of donor biomaterials (egg,
Modern, state-of-the-art sperm and embryos)
Embryology Unit
RI Witness system PGT-a of embryos
Uncompromising air purifica- (NGS method)
tion system, special param-
eters of clean zones Medical genetic
TimeLapse embryo incubators counselling
with 24hours development
tracking Dedicated International
Department
A wide range of andrology
laboratory possibilities, con-
servative and microsurgical
treatment of male infertility,
sperm cryopreservation

Infertility treatment by means
of Assisted Reproductive
Technologies

IVF programs Advantages

1. In Vitro Fertilization All types of IVF treatment
2. Natural cycle IVF available
3. Mini IVF
4. IUI Preparation process can be
5. Programs for patients with diminished ovarian administered remotely

reserve (banking of eggs and embryos)
6. Social egg freezing
7. IVM
8. Fertility preservation programs

Donation programs

1. Individual egg donation (fertilization of all native donor eggs
with IVF/ICSI)

2. Personalised egg donation (fertilization of 12 native donor eggs
with IVF/ICSI)

3. Natural cycle IVF (6 donor eggs or more - crossfertilization)
4. Donor sperm IVF/IUI
5. Embryo adoption

NGC donation program advantages

More than 600 egg and sperm donors
All donors pass genetic screening for hereditary diseases

Online selection: Credible profiles with more than 70 parameters,
child and adult pictures available

Non-anonymous donation

Egg donation is widely considered the last resort for patients failing to succeed with
own eggs.
It can be hard to attune to egg donation mentally, and start moving forward.
We at NGC understand what future parents seek when applying for a donation
program: They want to learn more about the person who will help make their dream
of having a baby a reality.
Luckily, the Russian IVF legal framework fully allows us to collect and share different
donor characteristics. We provide full biometrics, detailed information about
kids and relatives, donor’s education and occupation, hobbies, as well as many
other points. We give access to both child and adult photos of our donors, their
handwriting samples, voice recordings, and even more information that helps our
patients to make this important decision with comfort and ease. Moreover, the
donor’s personality reveal is permitted upon the child’s 18th birthday.
We equally value the result: The clinic guarantees at least 25% blastulation rate
in fresh donor cycles: 12 eggs cannot result in less than 3 embryos. We carefully
guide our patient during the selection process, and provide honest answers.

Our key advantages

More than 450 egg donors available for fresh egg donation

Transparent conditions: You can either take 12 fresh eggs or all fresh eggs
collected in 1 cycle

Credible and meticulous donor profiles

A possibility to select a donor by yourself or ask us for matching assistance

No waiting lists

Reduced length of stay: first, your partner deposits a sperm sample (1 day only).
Second, you arrive for a frozen embryo transfer (3-4 days maximum)

Timely online coordination

Non-anonymous donation allowed (unlike Greece, Spain or Czech Republic)

Choose the perfect
donor online!

Our donors undergo
extensive medical
examinations and are
screened for single-gene
diseases. Each donor
profile includes 70 different
characteristics

Donor’s criteria: Age How donors are screened?
Height
Fresh/Frozen Weight All donors pass the following tests: T. Pallidum, HIV,
Appearance Hepatitis B HBC, C HCV, Bacteriological smear, STD
Eye color Education test (Hepres, Gonococcus, Chlamidia, Cytomegalovirus,
Ureaplasm, Mycoplasm), Cariotyping, NextGen21,
Blood group/ blood group and Rh factor; all donors must provide an
RH factor opinion from psychoneurological clinic

Hair color ED: +PAP-smear, Clinical blood count, Biochemical
parametres in blood, Coagulogram, Urinanalisys, Anti-
Rubella IgG/IgM, Anti-HSV I, II IgG/IgM, Anti-CMV
IgG/IgM,Fluorography, ECG, Pelvic Ultrasound, Breast
ultrasound

SD: +spermogram

Donation
programs

Based on many years of experience We recruit egg donors from young
our team has developed optimal and healthy women with proved
egg donation packages with fertility, however according to the
guaranteed 12 eggs. We offer statistics even women younger than
several options of matching: 35 have around 30-35% of embryo
online by childhood photos on the aneuploidy after PGT-A. If recipient
database or personified matching wants to exclude potential risks of
by your photo and blood type chromosomal abnormalities within
with the help of an experienced egg donation cycle is suggested
coordinator PGT-A procedure before the transfer

Fertility preservation
programs for oncological
patients

Thanks to this program, patients have the
opportunity to save their own biological
material (sperm and eggs) for later use
in life. The need for this arises before
undergoing chemotherapeutic treatment
and / or radiation therapy, which have
a negative effect on reproductive health

We offer:

1. Sperm freezing
2. Egg / embryo vitrification
3. Ovarian tissue cryopreservation
Gametes undergo cryopreservation and
can be stored for an unlimited time in the
clinic’s cryobank. After achieving remission,
patients can return to the issue of procreation
and have genetically related babies in IVF
programs or with the help of surrogacy



Time-Lapse: 24/7, uninterrupted embryo
monitoring system

The dedicated elevator
system for biomaterial
exchange between the
Embryology and the
a Biology units

Incubators for embryo cultivation

11th grade air filtering
18-time per day full air refreshment
Independent system of supply-and-exhaust
ventilation

In-house Nitrogen
generation and storage
system

Hi-end IVF workstations
(laminar flow)

RI Witness: detection and Cryobank
monitoring system for
patients’ biomaterials

Genetics Lab

MARINA SVETLANA VIATKINA
KRECHMAR, MD
Head of Genetics Lab, PhD
Head of Clinical Genetics in Biology
Department, geneticist

ELVIRA ROMAN VASILYEV
POLENNIKOVA, MD
Director of the Institute
Geneticist for Genomic Research

Genetic counselling Consanguineous marriages

Indications: Risk assessment of hereditary
pathology
Established or suspected hereditary
pathology in the family

Pregnancy planning pre-IVF check-up

Habitual miscarriage

Preimplantation genetic testing
of embryos (PGT-a) by NGS method

The most modern and high-precision method of all existing

>30 000MORETHAN

TESTINGS ALREADY MADE!

Increasing the efficiency of IVF programs by selecting embryos without
genetic pathology
Analysis of all chromosome pairs simultaneously with the highest
accuracy compared to other methods
Test precision > 99%
At the NGC clinic, preimplantation genetic testing by the NGS method
is carried out on the world’s first FDA-registered sequencer of the new
generation MiSeqDx (Illumina, USA), designed specifically for clinical
laboratories

Monogenic carrier screening test —
NextGen21 + SMA

Based on high throughput sequencing technology (NGS). The test is aimed
at establishing the carrier status for the most common and severe hereditary
diseases, reveals both known mutations and previously undescribed pathogenic
variants.

The use allows the family to significantly reduce the likelihood of having children
with severe hereditary pathology. Based on the study, the geneticist calculates the
reproductive risk and develops individual recommendations for each family.

NextGen21 + SMA:
assessed genes

Gene Disease Inheritance
type
CFTR
PAH Cystic fibrosis AR
DMD Phenylketonuria AR
F8 Duchenne myodystrophy X-linked
Hemophilia A X-linked
HBB Beta thalassemia AR

APC Sickle cell anemia AR
MUTYHА
IDUA Familial adenomatous AD
PKD1 polyposis I and II AR
PKD2 AR
PMP22 Mucopolysaccharosis type I AD
Autosomal dominant AD
VHL AD
ATP7B polycystic kidney disease AD
type I and II
GBA AR
HEXA Charcot-Marie-Tooth disease
BRCA1 AR
BRCA2 Hippel-Lindau disease AR
AD
SMN1 Wilson-Konovalov disease AD
AR
Gaucher disease

Tay-Sachs disease
Hereditary breast
and ovarian cancer

types I and II

Спинальная амиотрофия

Andrology

VLADIMIR MOREV, MD

Chief Doctor at NGC St.Petersburg
urology and andrology specialist,
doctor of higher categories

Male infertility treatment
Treatment for hypoganadism, metabolic syndrome
Surgical treatment of varicocele (microsurgical varicocelectomy, Marmar

operation)
Surgical spermatozoa extraction (azoospermia)
Comprehensive analysis of the genetic causes of male infertility

Andrology Unit

A full range of ejaculate studies: physicochemical and microscopic analysis
MAR test - determination of antisperm antibodies
HBA-test - a functional test for the binding of spermatozoa to hyaluronic acid

Operations for azoospermia

Statistics Statistics

PESA MESA
Percutaneous aspiration Microsurgical biopsy
biopsy of the epididymis of the epididymis
(vasoepididymoanastomosis)

Statistics Statistics

TESA TESE
Percutaneous aspiration Open testicular biopsy
testicular biopsy

Statistics

Micro-TESE
Microdissection testicular biopsy

The most modern and effective method for obtaining
spermatozoa from the testicles

Our geography

KIROV
SAINT PETERSBURG

MOSCOW UFA

VLADIKAVKAZ

VLADIVOSTOK

Russia, St. Petersburg
ngc.clinic/en
[email protected]